-- dump date 20140620_020136 -- class Genbank::misc_feature -- table misc_feature_note -- id note 264730000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 264730000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264730000004 Walker A motif; other site 264730000005 ATP binding site [chemical binding]; other site 264730000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264730000007 Walker B motif; other site 264730000008 arginine finger; other site 264730000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 264730000010 DnaA box-binding interface [nucleotide binding]; other site 264730000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 264730000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 264730000013 putative DNA binding surface [nucleotide binding]; other site 264730000014 dimer interface [polypeptide binding]; other site 264730000015 beta-clamp/clamp loader binding surface; other site 264730000016 beta-clamp/translesion DNA polymerase binding surface; other site 264730000017 recombination protein F; Reviewed; Region: recF; PRK00064 264730000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730000019 Walker A/P-loop; other site 264730000020 ATP binding site [chemical binding]; other site 264730000021 Q-loop/lid; other site 264730000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730000023 ABC transporter signature motif; other site 264730000024 Walker B; other site 264730000025 D-loop; other site 264730000026 H-loop/switch region; other site 264730000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 264730000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730000029 ATP binding site [chemical binding]; other site 264730000030 Mg2+ binding site [ion binding]; other site 264730000031 G-X-G motif; other site 264730000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264730000033 anchoring element; other site 264730000034 dimer interface [polypeptide binding]; other site 264730000035 ATP binding site [chemical binding]; other site 264730000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 264730000037 active site 264730000038 putative metal-binding site [ion binding]; other site 264730000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264730000040 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264730000041 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264730000042 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 264730000043 Putative transposase; Region: Y2_Tnp; pfam04986 264730000044 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264730000045 molybdopterin cofactor binding site; other site 264730000046 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264730000047 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264730000048 putative acyl-acceptor binding pocket; other site 264730000049 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 264730000050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730000051 active site 264730000052 motif I; other site 264730000053 motif II; other site 264730000054 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 264730000055 HD domain; Region: HD; pfam01966 264730000056 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264730000057 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 264730000058 dimer interface [polypeptide binding]; other site 264730000059 motif 1; other site 264730000060 active site 264730000061 motif 2; other site 264730000062 motif 3; other site 264730000063 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 264730000064 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 264730000065 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 264730000066 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264730000067 putative acyl-acceptor binding pocket; other site 264730000068 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 264730000069 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 264730000070 Protein of unknown function (DUF1534); Region: DUF1534; pfam07551 264730000071 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 264730000072 Putative transposase; Region: Y2_Tnp; pfam04986 264730000073 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 264730000074 putative molybdopterin cofactor binding site [chemical binding]; other site 264730000075 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 264730000076 TrkA-N domain; Region: TrkA_N; pfam02254 264730000077 TrkA-C domain; Region: TrkA_C; pfam02080 264730000078 TrkA-N domain; Region: TrkA_N; pfam02254 264730000079 TrkA-C domain; Region: TrkA_C; pfam02080 264730000080 16S rRNA methyltransferase B; Provisional; Region: PRK10901 264730000081 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 264730000082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730000083 S-adenosylmethionine binding site [chemical binding]; other site 264730000084 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 264730000085 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 264730000086 putative active site [active] 264730000087 substrate binding site [chemical binding]; other site 264730000088 putative cosubstrate binding site; other site 264730000089 catalytic site [active] 264730000090 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 264730000091 substrate binding site [chemical binding]; other site 264730000092 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264730000093 active site 264730000094 catalytic residues [active] 264730000095 metal binding site [ion binding]; metal-binding site 264730000096 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264730000097 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 264730000098 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 264730000099 DNA protecting protein DprA; Region: dprA; TIGR00732 264730000100 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 264730000101 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264730000102 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264730000103 NADP binding site [chemical binding]; other site 264730000104 dimer interface [polypeptide binding]; other site 264730000105 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 264730000106 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 264730000107 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 264730000108 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264730000109 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264730000110 shikimate binding site; other site 264730000111 NAD(P) binding site [chemical binding]; other site 264730000112 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264730000113 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 264730000114 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264730000115 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264730000116 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 264730000117 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 264730000118 Sulfatase; Region: Sulfatase; cl17466 264730000119 choline-sulfatase; Region: chol_sulfatase; TIGR03417 264730000120 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 264730000121 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 264730000122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730000123 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264730000124 dimerization interface [polypeptide binding]; other site 264730000125 substrate binding pocket [chemical binding]; other site 264730000126 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 264730000127 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 264730000128 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 264730000129 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 264730000130 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 264730000131 substrate binding site [chemical binding]; other site 264730000132 active site 264730000133 catalytic residues [active] 264730000134 heterodimer interface [polypeptide binding]; other site 264730000135 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 264730000136 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 264730000137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730000138 catalytic residue [active] 264730000139 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264730000140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730000141 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 264730000142 putative dimerization interface [polypeptide binding]; other site 264730000143 putative substrate binding pocket [chemical binding]; other site 264730000144 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 264730000145 Dodecin; Region: Dodecin; pfam07311 264730000146 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 264730000147 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 264730000148 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 264730000149 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 264730000150 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 264730000151 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730000152 MULE transposase domain; Region: MULE; pfam10551 264730000153 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 264730000154 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730000155 MULE transposase domain; Region: MULE; pfam10551 264730000156 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264730000157 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 264730000158 trimer interface [polypeptide binding]; other site 264730000159 putative metal binding site [ion binding]; other site 264730000160 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 264730000161 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 264730000162 active site 264730000163 Zn binding site [ion binding]; other site 264730000164 conserved hypothetical metal-binding protein; Region: TIGR02443 264730000165 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 264730000166 Cytochrome c; Region: Cytochrom_C; pfam00034 264730000167 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 264730000168 LysE type translocator; Region: LysE; cl00565 264730000169 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264730000170 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264730000171 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 264730000172 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264730000173 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264730000174 ABC transporter; Region: ABC_tran_2; pfam12848 264730000175 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264730000176 TIGR02444 family protein; Region: TIGR02444 264730000177 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 264730000178 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 264730000179 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264730000180 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 264730000181 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 264730000182 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 264730000183 HemY protein N-terminus; Region: HemY_N; pfam07219 264730000184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730000185 binding surface 264730000186 TPR motif; other site 264730000187 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 264730000188 uroporphyrinogen-III synthase; Validated; Region: PRK05752 264730000189 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 264730000190 active site 264730000191 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 264730000192 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 264730000193 domain interfaces; other site 264730000194 active site 264730000195 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264730000196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730000197 active site 264730000198 phosphorylation site [posttranslational modification] 264730000199 intermolecular recognition site; other site 264730000200 dimerization interface [polypeptide binding]; other site 264730000201 LytTr DNA-binding domain; Region: LytTR; pfam04397 264730000202 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 264730000203 Histidine kinase; Region: His_kinase; pfam06580 264730000204 argininosuccinate lyase; Provisional; Region: PRK00855 264730000205 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 264730000206 active sites [active] 264730000207 tetramer interface [polypeptide binding]; other site 264730000208 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 264730000209 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 264730000210 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 264730000211 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264730000212 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264730000213 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264730000214 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 264730000215 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264730000216 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264730000217 PhoU domain; Region: PhoU; pfam01895 264730000218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730000219 dimerization interface [polypeptide binding]; other site 264730000220 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730000221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730000222 dimer interface [polypeptide binding]; other site 264730000223 putative CheW interface [polypeptide binding]; other site 264730000224 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264730000225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730000226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730000227 dimerization interface [polypeptide binding]; other site 264730000228 multidrug efflux protein NorA; Provisional; Region: PRK00187 264730000229 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 264730000230 cation binding site [ion binding]; other site 264730000231 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730000232 metal binding site [ion binding]; metal-binding site 264730000233 active site 264730000234 I-site; other site 264730000235 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730000236 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 264730000237 Family description; Region: UvrD_C_2; pfam13538 264730000238 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264730000239 active site 264730000240 PAS domain; Region: PAS_9; pfam13426 264730000241 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264730000242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730000243 Walker A motif; other site 264730000244 ATP binding site [chemical binding]; other site 264730000245 Walker B motif; other site 264730000246 arginine finger; other site 264730000247 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730000248 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264730000249 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 264730000250 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264730000251 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 264730000252 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 264730000253 Walker A/P-loop; other site 264730000254 ATP binding site [chemical binding]; other site 264730000255 Q-loop/lid; other site 264730000256 ABC transporter signature motif; other site 264730000257 Walker B; other site 264730000258 D-loop; other site 264730000259 H-loop/switch region; other site 264730000260 TOBE-like domain; Region: TOBE_3; pfam12857 264730000261 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 264730000262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730000263 dimer interface [polypeptide binding]; other site 264730000264 conserved gate region; other site 264730000265 putative PBP binding loops; other site 264730000266 ABC-ATPase subunit interface; other site 264730000267 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 264730000268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730000269 dimer interface [polypeptide binding]; other site 264730000270 conserved gate region; other site 264730000271 putative PBP binding loops; other site 264730000272 ABC-ATPase subunit interface; other site 264730000273 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 264730000274 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264730000275 Uncharacterized small protein [Function unknown]; Region: COG5583 264730000276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730000277 PAS domain; Region: PAS_9; pfam13426 264730000278 putative active site [active] 264730000279 heme pocket [chemical binding]; other site 264730000280 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730000281 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730000282 metal binding site [ion binding]; metal-binding site 264730000283 active site 264730000284 I-site; other site 264730000285 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730000286 Fatty acid desaturase; Region: FA_desaturase; pfam00487 264730000287 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 264730000288 Di-iron ligands [ion binding]; other site 264730000289 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 264730000290 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264730000291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730000292 PAS fold; Region: PAS_3; pfam08447 264730000293 putative active site [active] 264730000294 heme pocket [chemical binding]; other site 264730000295 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730000296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730000297 metal binding site [ion binding]; metal-binding site 264730000298 active site 264730000299 I-site; other site 264730000300 Response regulator receiver domain; Region: Response_reg; pfam00072 264730000301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730000302 active site 264730000303 phosphorylation site [posttranslational modification] 264730000304 intermolecular recognition site; other site 264730000305 dimerization interface [polypeptide binding]; other site 264730000306 HDOD domain; Region: HDOD; pfam08668 264730000307 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 264730000308 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730000309 inhibitor-cofactor binding pocket; inhibition site 264730000310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730000311 catalytic residue [active] 264730000312 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 264730000313 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264730000314 tetramerization interface [polypeptide binding]; other site 264730000315 NAD(P) binding site [chemical binding]; other site 264730000316 catalytic residues [active] 264730000317 hypothetical protein; Provisional; Region: PRK07236 264730000318 hypothetical protein; Provisional; Region: PRK07588 264730000319 integrase; Provisional; Region: int; PHA02601 264730000320 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730000321 active site 264730000322 DNA binding site [nucleotide binding] 264730000323 Int/Topo IB signature motif; other site 264730000324 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264730000325 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 264730000326 catalytic residues [active] 264730000327 catalytic nucleophile [active] 264730000328 Recombinase; Region: Recombinase; pfam07508 264730000329 ParB-like nuclease domain; Region: ParB; smart00470 264730000330 RepB plasmid partitioning protein; Region: RepB; pfam07506 264730000331 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 264730000332 ParB-like nuclease domain; Region: ParB; smart00470 264730000333 RepB plasmid partitioning protein; Region: RepB; pfam07506 264730000334 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 264730000335 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 264730000336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 264730000337 ATP binding site [chemical binding]; other site 264730000338 putative Mg++ binding site [ion binding]; other site 264730000339 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 264730000340 Divergent AAA domain; Region: AAA_4; pfam04326 264730000341 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 264730000342 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 264730000343 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264730000344 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264730000345 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 264730000346 HsdM N-terminal domain; Region: HsdM_N; pfam12161 264730000347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730000348 S-adenosylmethionine binding site [chemical binding]; other site 264730000349 C factor cell-cell signaling protein; Provisional; Region: PRK09009 264730000350 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 264730000351 NADP binding site [chemical binding]; other site 264730000352 homodimer interface [polypeptide binding]; other site 264730000353 active site 264730000354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264730000355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730000356 Coenzyme A binding pocket [chemical binding]; other site 264730000357 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730000358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730000359 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730000360 Transposase domain (DUF772); Region: DUF772; pfam05598 264730000361 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 264730000362 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264730000363 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264730000364 Sel1-like repeats; Region: SEL1; smart00671 264730000365 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264730000366 Sel1-like repeats; Region: SEL1; smart00671 264730000367 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264730000368 putative active site [active] 264730000369 catalytic site [active] 264730000370 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264730000371 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 264730000372 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 264730000373 putative active site [active] 264730000374 catalytic site [active] 264730000375 PAAR motif; Region: PAAR_motif; pfam05488 264730000376 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730000377 MULE transposase domain; Region: MULE; pfam10551 264730000378 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 264730000379 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 264730000380 Protein of unknown function (DUF796); Region: DUF796; pfam05638 264730000381 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 264730000382 G1 box; other site 264730000383 GTP/Mg2+ binding site [chemical binding]; other site 264730000384 G2 box; other site 264730000385 G3 box; other site 264730000386 Switch II region; other site 264730000387 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 264730000388 G4 box; other site 264730000389 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730000390 ligand binding site [chemical binding]; other site 264730000391 type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373 264730000392 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 264730000393 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 264730000394 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 264730000395 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 264730000396 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 264730000397 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 264730000398 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 264730000399 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 264730000400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730000401 Walker A motif; other site 264730000402 ATP binding site [chemical binding]; other site 264730000403 Walker B motif; other site 264730000404 arginine finger; other site 264730000405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730000406 Walker A motif; other site 264730000407 ATP binding site [chemical binding]; other site 264730000408 Walker B motif; other site 264730000409 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 264730000410 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 264730000411 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 264730000412 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 264730000413 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 264730000414 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 264730000415 Protein of unknown function (DUF877); Region: DUF877; pfam05943 264730000416 Protein of unknown function (DUF770); Region: DUF770; pfam05591 264730000417 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 264730000418 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 264730000419 putative molybdopterin cofactor binding site [chemical binding]; other site 264730000420 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 264730000421 putative molybdopterin cofactor binding site; other site 264730000422 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 264730000423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730000424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730000425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264730000426 dimerization interface [polypeptide binding]; other site 264730000427 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 264730000428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730000429 motif II; other site 264730000430 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 264730000431 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 264730000432 dimer interface [polypeptide binding]; other site 264730000433 ADP-ribose binding site [chemical binding]; other site 264730000434 active site 264730000435 nudix motif; other site 264730000436 metal binding site [ion binding]; metal-binding site 264730000437 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 264730000438 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 264730000439 active site 264730000440 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 264730000441 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264730000442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730000443 active site 264730000444 phosphorylation site [posttranslational modification] 264730000445 intermolecular recognition site; other site 264730000446 dimerization interface [polypeptide binding]; other site 264730000447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730000448 Walker A motif; other site 264730000449 ATP binding site [chemical binding]; other site 264730000450 Walker B motif; other site 264730000451 arginine finger; other site 264730000452 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 264730000453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730000454 dimer interface [polypeptide binding]; other site 264730000455 phosphorylation site [posttranslational modification] 264730000456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730000457 ATP binding site [chemical binding]; other site 264730000458 Mg2+ binding site [ion binding]; other site 264730000459 G-X-G motif; other site 264730000460 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 264730000461 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 264730000462 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 264730000463 NAD binding site [chemical binding]; other site 264730000464 substrate binding site [chemical binding]; other site 264730000465 homodimer interface [polypeptide binding]; other site 264730000466 active site 264730000467 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 264730000468 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 264730000469 putative active site; other site 264730000470 catalytic triad [active] 264730000471 putative dimer interface [polypeptide binding]; other site 264730000472 agmatine deiminase; Provisional; Region: PRK13551 264730000473 agmatine deiminase; Region: agmatine_aguA; TIGR03380 264730000474 outer membrane porin, OprD family; Region: OprD; pfam03573 264730000475 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264730000476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264730000477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730000478 Coenzyme A binding pocket [chemical binding]; other site 264730000479 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 264730000480 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 264730000481 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730000482 transposase/IS protein; Provisional; Region: PRK09183 264730000483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730000484 Walker A motif; other site 264730000485 ATP binding site [chemical binding]; other site 264730000486 Walker B motif; other site 264730000487 arginine finger; other site 264730000488 Protein of unknown function (DUF796); Region: DUF796; pfam05638 264730000489 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730000490 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264730000491 active site 264730000492 catalytic residues [active] 264730000493 DNA binding site [nucleotide binding] 264730000494 Int/Topo IB signature motif; other site 264730000495 Transposase domain (DUF772); Region: DUF772; pfam05598 264730000496 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 264730000497 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264730000498 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730000499 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730000500 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730000501 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 264730000502 metal binding site [ion binding]; metal-binding site 264730000503 putative dimer interface [polypeptide binding]; other site 264730000504 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730000505 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264730000506 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730000507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730000508 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730000509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730000510 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 264730000511 putative effector binding pocket; other site 264730000512 putative dimerization interface [polypeptide binding]; other site 264730000513 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 264730000514 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264730000515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730000516 Walker A motif; other site 264730000517 ATP binding site [chemical binding]; other site 264730000518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730000519 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264730000520 Walker A motif; other site 264730000521 ATP binding site [chemical binding]; other site 264730000522 Walker B motif; other site 264730000523 arginine finger; other site 264730000524 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 264730000525 active site 264730000526 catalytic triad [active] 264730000527 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 264730000528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730000529 AAA domain; Region: AAA_22; pfam13401 264730000530 Walker A motif; other site 264730000531 ATP binding site [chemical binding]; other site 264730000532 Walker B motif; other site 264730000533 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 264730000534 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 264730000535 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 264730000536 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 264730000537 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 264730000538 Citrate transporter; Region: CitMHS; pfam03600 264730000539 Uncharacterized conserved protein [Function unknown]; Region: COG3791 264730000540 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 264730000541 putative deacylase active site [active] 264730000542 HDOD domain; Region: HDOD; pfam08668 264730000543 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 264730000544 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 264730000545 generic binding surface II; other site 264730000546 ssDNA binding site; other site 264730000547 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264730000548 ATP binding site [chemical binding]; other site 264730000549 putative Mg++ binding site [ion binding]; other site 264730000550 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730000551 nucleotide binding region [chemical binding]; other site 264730000552 ATP-binding site [chemical binding]; other site 264730000553 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 264730000554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730000555 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 264730000556 dimerization interface [polypeptide binding]; other site 264730000557 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264730000558 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264730000559 biopolymer transport protein ExbD; Provisional; Region: PRK11267 264730000560 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264730000561 tonB-system energizer ExbB; Region: exbB; TIGR02797 264730000562 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264730000563 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 264730000564 putative NAD(P) binding site [chemical binding]; other site 264730000565 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264730000566 homotrimer interaction site [polypeptide binding]; other site 264730000567 putative active site [active] 264730000568 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 264730000569 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264730000570 Zn2+ binding site [ion binding]; other site 264730000571 Mg2+ binding site [ion binding]; other site 264730000572 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264730000573 synthetase active site [active] 264730000574 NTP binding site [chemical binding]; other site 264730000575 metal binding site [ion binding]; metal-binding site 264730000576 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264730000577 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264730000578 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 264730000579 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 264730000580 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 264730000581 catalytic site [active] 264730000582 G-X2-G-X-G-K; other site 264730000583 hypothetical protein; Provisional; Region: PRK11820 264730000584 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 264730000585 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 264730000586 ribonuclease PH; Reviewed; Region: rph; PRK00173 264730000587 Ribonuclease PH; Region: RNase_PH_bact; cd11362 264730000588 hexamer interface [polypeptide binding]; other site 264730000589 active site 264730000590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 264730000591 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 264730000592 putative active site [active] 264730000593 putative catalytic site [active] 264730000594 putative DNA binding site [nucleotide binding]; other site 264730000595 putative phosphate binding site [ion binding]; other site 264730000596 metal binding site A [ion binding]; metal-binding site 264730000597 putative AP binding site [nucleotide binding]; other site 264730000598 putative metal binding site B [ion binding]; other site 264730000599 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264730000600 active site 264730000601 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 264730000602 feedback inhibition sensing region; other site 264730000603 homohexameric interface [polypeptide binding]; other site 264730000604 nucleotide binding site [chemical binding]; other site 264730000605 N-acetyl-L-glutamate binding site [chemical binding]; other site 264730000606 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 264730000607 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 264730000608 active site 264730000609 substrate binding site [chemical binding]; other site 264730000610 metal binding site [ion binding]; metal-binding site 264730000611 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264730000612 trimer interface [polypeptide binding]; other site 264730000613 active site 264730000614 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 264730000615 Flavoprotein; Region: Flavoprotein; pfam02441 264730000616 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 264730000617 hypothetical protein; Reviewed; Region: PRK00024 264730000618 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 264730000619 MPN+ (JAMM) motif; other site 264730000620 Zinc-binding site [ion binding]; other site 264730000621 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264730000622 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 264730000623 peptide binding site [polypeptide binding]; other site 264730000624 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 264730000625 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 264730000626 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 264730000627 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 264730000628 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 264730000629 NAD(P) binding site [chemical binding]; other site 264730000630 catalytic residues [active] 264730000631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730000632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 264730000633 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 264730000634 PLD-like domain; Region: PLDc_2; pfam13091 264730000635 putative active site [active] 264730000636 catalytic site [active] 264730000637 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 264730000638 PLD-like domain; Region: PLDc_2; pfam13091 264730000639 putative active site [active] 264730000640 catalytic site [active] 264730000641 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264730000642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730000643 DNA-binding site [nucleotide binding]; DNA binding site 264730000644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730000645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730000646 homodimer interface [polypeptide binding]; other site 264730000647 catalytic residue [active] 264730000648 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 264730000649 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264730000650 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264730000651 Flagellin N-methylase; Region: FliB; pfam03692 264730000652 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 264730000653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730000654 putative DNA binding site [nucleotide binding]; other site 264730000655 putative Zn2+ binding site [ion binding]; other site 264730000656 AsnC family; Region: AsnC_trans_reg; pfam01037 264730000657 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 264730000658 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 264730000659 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264730000660 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 264730000661 homotrimer interaction site [polypeptide binding]; other site 264730000662 putative active site [active] 264730000663 alanine racemase; Reviewed; Region: dadX; PRK03646 264730000664 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 264730000665 active site 264730000666 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264730000667 substrate binding site [chemical binding]; other site 264730000668 catalytic residues [active] 264730000669 dimer interface [polypeptide binding]; other site 264730000670 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 264730000671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730000672 non-specific DNA binding site [nucleotide binding]; other site 264730000673 salt bridge; other site 264730000674 sequence-specific DNA binding site [nucleotide binding]; other site 264730000675 Cupin domain; Region: Cupin_2; pfam07883 264730000676 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 264730000677 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 264730000678 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 264730000679 Predicted membrane protein [Function unknown]; Region: COG4539 264730000680 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264730000681 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264730000682 ligand binding site [chemical binding]; other site 264730000683 flexible hinge region; other site 264730000684 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 264730000685 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 264730000686 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 264730000687 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 264730000688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730000689 dimer interface [polypeptide binding]; other site 264730000690 conserved gate region; other site 264730000691 putative PBP binding loops; other site 264730000692 ABC-ATPase subunit interface; other site 264730000693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730000694 dimer interface [polypeptide binding]; other site 264730000695 conserved gate region; other site 264730000696 putative PBP binding loops; other site 264730000697 ABC-ATPase subunit interface; other site 264730000698 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 264730000699 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264730000700 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264730000701 lipoyl attachment site [posttranslational modification]; other site 264730000702 conserverd hypothetical protein; Region: TIGR02448 264730000703 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 264730000704 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 264730000705 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264730000706 Walker A motif; other site 264730000707 ATP binding site [chemical binding]; other site 264730000708 Walker B motif; other site 264730000709 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264730000710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730000711 putative DNA binding site [nucleotide binding]; other site 264730000712 putative Zn2+ binding site [ion binding]; other site 264730000713 AsnC family; Region: AsnC_trans_reg; pfam01037 264730000714 Uncharacterized conserved protein [Function unknown]; Region: COG3025 264730000715 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 264730000716 putative active site [active] 264730000717 putative metal binding residues [ion binding]; other site 264730000718 signature motif; other site 264730000719 putative triphosphate binding site [ion binding]; other site 264730000720 acetylornithine deacetylase; Provisional; Region: PRK05111 264730000721 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 264730000722 metal binding site [ion binding]; metal-binding site 264730000723 putative dimer interface [polypeptide binding]; other site 264730000724 N-acetylglutamate synthase; Validated; Region: PRK05279 264730000725 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 264730000726 putative feedback inhibition sensing region; other site 264730000727 putative nucleotide binding site [chemical binding]; other site 264730000728 putative substrate binding site [chemical binding]; other site 264730000729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730000730 Coenzyme A binding pocket [chemical binding]; other site 264730000731 glutamate--cysteine ligase; Provisional; Region: PRK02107 264730000732 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264730000733 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 264730000734 CoenzymeA binding site [chemical binding]; other site 264730000735 subunit interaction site [polypeptide binding]; other site 264730000736 PHB binding site; other site 264730000737 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 264730000738 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 264730000739 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 264730000740 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 264730000741 RNA binding site [nucleotide binding]; other site 264730000742 osmolarity response regulator; Provisional; Region: ompR; PRK09468 264730000743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730000744 active site 264730000745 phosphorylation site [posttranslational modification] 264730000746 intermolecular recognition site; other site 264730000747 dimerization interface [polypeptide binding]; other site 264730000748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730000749 DNA binding site [nucleotide binding] 264730000750 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 264730000751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730000752 dimerization interface [polypeptide binding]; other site 264730000753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730000754 ATP binding site [chemical binding]; other site 264730000755 Mg2+ binding site [ion binding]; other site 264730000756 G-X-G motif; other site 264730000757 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 264730000758 BON domain; Region: BON; pfam04972 264730000759 BON domain; Region: BON; pfam04972 264730000760 BON domain; Region: BON; pfam04972 264730000761 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264730000762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730000763 active site 264730000764 phosphorylation site [posttranslational modification] 264730000765 intermolecular recognition site; other site 264730000766 dimerization interface [polypeptide binding]; other site 264730000767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730000768 Walker A motif; other site 264730000769 ATP binding site [chemical binding]; other site 264730000770 Walker B motif; other site 264730000771 arginine finger; other site 264730000772 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730000773 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730000774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730000775 dimerization interface [polypeptide binding]; other site 264730000776 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264730000777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730000778 putative active site [active] 264730000779 heme pocket [chemical binding]; other site 264730000780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730000781 dimer interface [polypeptide binding]; other site 264730000782 phosphorylation site [posttranslational modification] 264730000783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730000784 ATP binding site [chemical binding]; other site 264730000785 Mg2+ binding site [ion binding]; other site 264730000786 G-X-G motif; other site 264730000787 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 264730000788 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264730000789 amidase catalytic site [active] 264730000790 Zn binding residues [ion binding]; other site 264730000791 substrate binding site [chemical binding]; other site 264730000792 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 264730000793 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730000794 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730000795 metal binding site [ion binding]; metal-binding site 264730000796 active site 264730000797 I-site; other site 264730000798 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264730000799 putative catalytic site [active] 264730000800 putative metal binding site [ion binding]; other site 264730000801 putative phosphate binding site [ion binding]; other site 264730000802 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 264730000803 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 264730000804 catalytic residues [active] 264730000805 hinge region; other site 264730000806 alpha helical domain; other site 264730000807 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 264730000808 G1 box; other site 264730000809 GTP/Mg2+ binding site [chemical binding]; other site 264730000810 Switch I region; other site 264730000811 G2 box; other site 264730000812 G3 box; other site 264730000813 Switch II region; other site 264730000814 G4 box; other site 264730000815 G5 box; other site 264730000816 DNA polymerase I; Provisional; Region: PRK05755 264730000817 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 264730000818 active site 264730000819 metal binding site 1 [ion binding]; metal-binding site 264730000820 putative 5' ssDNA interaction site; other site 264730000821 metal binding site 3; metal-binding site 264730000822 metal binding site 2 [ion binding]; metal-binding site 264730000823 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 264730000824 putative DNA binding site [nucleotide binding]; other site 264730000825 putative metal binding site [ion binding]; other site 264730000826 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 264730000827 active site 264730000828 catalytic site [active] 264730000829 substrate binding site [chemical binding]; other site 264730000830 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 264730000831 active site 264730000832 DNA binding site [nucleotide binding] 264730000833 catalytic site [active] 264730000834 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 264730000835 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 264730000836 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 264730000837 putative active site [active] 264730000838 putative substrate binding site [chemical binding]; other site 264730000839 ATP binding site [chemical binding]; other site 264730000840 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 264730000841 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 264730000842 metal binding site [ion binding]; metal-binding site 264730000843 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264730000844 metal binding site 2 [ion binding]; metal-binding site 264730000845 putative DNA binding helix; other site 264730000846 metal binding site 1 [ion binding]; metal-binding site 264730000847 dimer interface [polypeptide binding]; other site 264730000848 structural Zn2+ binding site [ion binding]; other site 264730000849 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 264730000850 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 264730000851 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 264730000852 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264730000853 dimer interface [polypeptide binding]; other site 264730000854 putative PBP binding regions; other site 264730000855 ABC-ATPase subunit interface; other site 264730000856 hydroperoxidase II; Provisional; Region: katE; PRK11249 264730000857 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 264730000858 tetramer interface [polypeptide binding]; other site 264730000859 heme binding pocket [chemical binding]; other site 264730000860 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 264730000861 domain interactions; other site 264730000862 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 264730000863 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 264730000864 Walker A/P-loop; other site 264730000865 ATP binding site [chemical binding]; other site 264730000866 Q-loop/lid; other site 264730000867 ABC transporter signature motif; other site 264730000868 Walker B; other site 264730000869 D-loop; other site 264730000870 H-loop/switch region; other site 264730000871 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 264730000872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730000873 conserved gate region; other site 264730000874 ABC-ATPase subunit interface; other site 264730000875 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 264730000876 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 264730000877 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 264730000878 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 264730000879 Cu(I) binding site [ion binding]; other site 264730000880 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 264730000881 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264730000882 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264730000883 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 264730000884 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 264730000885 active site clefts [active] 264730000886 zinc binding site [ion binding]; other site 264730000887 dimer interface [polypeptide binding]; other site 264730000888 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 264730000889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730000890 FeS/SAM binding site; other site 264730000891 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 264730000892 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 264730000893 conserved cys residue [active] 264730000894 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264730000895 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 264730000896 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 264730000897 dimer interface [polypeptide binding]; other site 264730000898 active site 264730000899 aspartate-rich active site metal binding site; other site 264730000900 allosteric magnesium binding site [ion binding]; other site 264730000901 Schiff base residues; other site 264730000902 polyphosphate kinase; Provisional; Region: PRK05443 264730000903 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 264730000904 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 264730000905 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264730000906 putative active site [active] 264730000907 catalytic site [active] 264730000908 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 264730000909 putative domain interface [polypeptide binding]; other site 264730000910 putative active site [active] 264730000911 catalytic site [active] 264730000912 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 264730000913 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 264730000914 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264730000915 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264730000916 Walker A/P-loop; other site 264730000917 ATP binding site [chemical binding]; other site 264730000918 Q-loop/lid; other site 264730000919 ABC transporter signature motif; other site 264730000920 Walker B; other site 264730000921 D-loop; other site 264730000922 H-loop/switch region; other site 264730000923 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730000924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730000925 dimer interface [polypeptide binding]; other site 264730000926 conserved gate region; other site 264730000927 putative PBP binding loops; other site 264730000928 ABC-ATPase subunit interface; other site 264730000929 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730000930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730000931 dimer interface [polypeptide binding]; other site 264730000932 conserved gate region; other site 264730000933 putative PBP binding loops; other site 264730000934 ABC-ATPase subunit interface; other site 264730000935 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730000936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730000937 substrate binding pocket [chemical binding]; other site 264730000938 membrane-bound complex binding site; other site 264730000939 hinge residues; other site 264730000940 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730000941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730000942 DNA-binding site [nucleotide binding]; DNA binding site 264730000943 FCD domain; Region: FCD; pfam07729 264730000944 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264730000945 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264730000946 catalytic residues [active] 264730000947 transcription termination factor Rho; Provisional; Region: rho; PRK09376 264730000948 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 264730000949 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 264730000950 RNA binding site [nucleotide binding]; other site 264730000951 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 264730000952 multimer interface [polypeptide binding]; other site 264730000953 Walker A motif; other site 264730000954 ATP binding site [chemical binding]; other site 264730000955 Walker B motif; other site 264730000956 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 264730000957 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264730000958 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264730000959 catalytic loop [active] 264730000960 iron binding site [ion binding]; other site 264730000961 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 264730000962 FAD binding pocket [chemical binding]; other site 264730000963 FAD binding motif [chemical binding]; other site 264730000964 phosphate binding motif [ion binding]; other site 264730000965 beta-alpha-beta structure motif; other site 264730000966 NAD binding pocket [chemical binding]; other site 264730000967 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 264730000968 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 264730000969 putative active site pocket [active] 264730000970 dimerization interface [polypeptide binding]; other site 264730000971 putative catalytic residue [active] 264730000972 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 264730000973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730000974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730000975 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264730000976 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264730000977 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 264730000978 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264730000979 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 264730000980 NAD(P) binding site [chemical binding]; other site 264730000981 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 264730000982 EVE domain; Region: EVE; cl00728 264730000983 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 264730000984 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 264730000985 Cell division protein ZapA; Region: ZapA; pfam05164 264730000986 TIGR02449 family protein; Region: TIGR02449 264730000987 hypothetical protein; Reviewed; Region: PRK02166 264730000988 proline aminopeptidase P II; Provisional; Region: PRK10879 264730000989 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 264730000990 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 264730000991 active site 264730000992 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 264730000993 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 264730000994 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 264730000995 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264730000996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730000997 D-galactonate transporter; Region: 2A0114; TIGR00893 264730000998 putative substrate translocation pore; other site 264730000999 Serine hydrolase; Region: Ser_hydrolase; pfam06821 264730001000 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730001001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730001002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264730001003 Walker A motif; other site 264730001004 ATP binding site [chemical binding]; other site 264730001005 Walker B motif; other site 264730001006 arginine finger; other site 264730001007 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 264730001008 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 264730001009 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264730001010 Secretory lipase; Region: LIP; pfam03583 264730001011 H+ Antiporter protein; Region: 2A0121; TIGR00900 264730001012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730001013 putative substrate translocation pore; other site 264730001014 GAD-like domain; Region: GAD-like; pfam08887 264730001015 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 264730001016 GAD-like domain; Region: GAD-like; pfam08887 264730001017 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 264730001018 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 264730001019 active site 264730001020 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264730001021 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 264730001022 Autotransporter beta-domain; Region: Autotransporter; pfam03797 264730001023 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264730001024 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264730001025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264730001026 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264730001027 Walker A/P-loop; other site 264730001028 ATP binding site [chemical binding]; other site 264730001029 Q-loop/lid; other site 264730001030 ABC transporter signature motif; other site 264730001031 Walker B; other site 264730001032 D-loop; other site 264730001033 H-loop/switch region; other site 264730001034 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264730001035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730001036 dimer interface [polypeptide binding]; other site 264730001037 conserved gate region; other site 264730001038 putative PBP binding loops; other site 264730001039 ABC-ATPase subunit interface; other site 264730001040 NMT1-like family; Region: NMT1_2; pfam13379 264730001041 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264730001042 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730001043 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730001044 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264730001045 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730001046 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264730001047 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730001048 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730001049 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264730001050 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264730001051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730001052 S-adenosylmethionine binding site [chemical binding]; other site 264730001053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730001054 dimer interface [polypeptide binding]; other site 264730001055 conserved gate region; other site 264730001056 ABC-ATPase subunit interface; other site 264730001057 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 264730001058 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 264730001059 Walker A/P-loop; other site 264730001060 ATP binding site [chemical binding]; other site 264730001061 Q-loop/lid; other site 264730001062 ABC transporter signature motif; other site 264730001063 Walker B; other site 264730001064 D-loop; other site 264730001065 H-loop/switch region; other site 264730001066 NIL domain; Region: NIL; pfam09383 264730001067 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 264730001068 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 264730001069 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 264730001070 active site 264730001071 non-prolyl cis peptide bond; other site 264730001072 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 264730001073 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264730001074 active site 264730001075 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 264730001076 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264730001077 active site 264730001078 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730001079 MULE transposase domain; Region: MULE; pfam10551 264730001080 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 264730001081 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264730001082 Walker A/P-loop; other site 264730001083 ATP binding site [chemical binding]; other site 264730001084 Q-loop/lid; other site 264730001085 ABC transporter signature motif; other site 264730001086 Walker B; other site 264730001087 D-loop; other site 264730001088 H-loop/switch region; other site 264730001089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730001090 dimer interface [polypeptide binding]; other site 264730001091 conserved gate region; other site 264730001092 putative PBP binding loops; other site 264730001093 ABC-ATPase subunit interface; other site 264730001094 cystine transporter subunit; Provisional; Region: PRK11260 264730001095 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730001096 substrate binding pocket [chemical binding]; other site 264730001097 membrane-bound complex binding site; other site 264730001098 hinge residues; other site 264730001099 D-cysteine desulfhydrase; Validated; Region: PRK03910 264730001100 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264730001101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730001102 catalytic residue [active] 264730001103 serine O-acetyltransferase; Region: cysE; TIGR01172 264730001104 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264730001105 trimer interface [polypeptide binding]; other site 264730001106 active site 264730001107 substrate binding site [chemical binding]; other site 264730001108 CoA binding site [chemical binding]; other site 264730001109 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730001110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 264730001111 Anti-sigma-K factor rskA; Region: RskA; pfam10099 264730001112 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 264730001113 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 264730001114 HutD; Region: HutD; pfam05962 264730001115 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 264730001116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730001117 DNA-binding site [nucleotide binding]; DNA binding site 264730001118 UTRA domain; Region: UTRA; pfam07702 264730001119 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 264730001120 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 264730001121 active site 264730001122 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 264730001123 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 264730001124 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 264730001125 fructose-1,6-bisphosphatase family protein; Region: PLN02628 264730001126 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 264730001127 AMP binding site [chemical binding]; other site 264730001128 metal binding site [ion binding]; metal-binding site 264730001129 active site 264730001130 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 264730001131 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 264730001132 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 264730001133 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 264730001134 homodimer interface [polypeptide binding]; other site 264730001135 active site pocket [active] 264730001136 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 264730001137 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 264730001138 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 264730001139 putative active site [active] 264730001140 dimerization interface [polypeptide binding]; other site 264730001141 putative tRNAtyr binding site [nucleotide binding]; other site 264730001142 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 264730001143 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 264730001144 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 264730001145 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 264730001146 Ligand binding site; other site 264730001147 DXD motif; other site 264730001148 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730001149 dimerization interface [polypeptide binding]; other site 264730001150 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730001151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730001152 dimer interface [polypeptide binding]; other site 264730001153 putative CheW interface [polypeptide binding]; other site 264730001154 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730001155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730001156 dimerization interface [polypeptide binding]; other site 264730001157 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730001158 dimer interface [polypeptide binding]; other site 264730001159 putative CheW interface [polypeptide binding]; other site 264730001160 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 264730001161 RNA methyltransferase, RsmE family; Region: TIGR00046 264730001162 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 264730001163 sec-independent translocase; Provisional; Region: tatB; PRK00404 264730001164 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 264730001165 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 264730001166 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 264730001167 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 264730001168 metal binding site [ion binding]; metal-binding site 264730001169 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 264730001170 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 264730001171 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 264730001172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 264730001173 SCP-2 sterol transfer family; Region: SCP2; pfam02036 264730001174 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 264730001175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730001176 S-adenosylmethionine binding site [chemical binding]; other site 264730001177 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 264730001178 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 264730001179 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 264730001180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730001181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730001182 Bacterial transcriptional repressor; Region: TetR; pfam13972 264730001183 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 264730001184 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 264730001185 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 264730001186 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 264730001187 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 264730001188 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 264730001189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 264730001190 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 264730001191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730001192 Walker A motif; other site 264730001193 ATP binding site [chemical binding]; other site 264730001194 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 264730001195 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264730001196 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 264730001197 active site 264730001198 HslU subunit interaction site [polypeptide binding]; other site 264730001199 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 264730001200 Sporulation related domain; Region: SPOR; pfam05036 264730001201 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 264730001202 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 264730001203 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 264730001204 active site 264730001205 HIGH motif; other site 264730001206 KMSK motif region; other site 264730001207 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 264730001208 tRNA binding surface [nucleotide binding]; other site 264730001209 anticodon binding site; other site 264730001210 primosome assembly protein PriA; Validated; Region: PRK05580 264730001211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264730001212 ATP binding site [chemical binding]; other site 264730001213 putative Mg++ binding site [ion binding]; other site 264730001214 helicase superfamily c-terminal domain; Region: HELICc; smart00490 264730001215 ATP-binding site [chemical binding]; other site 264730001216 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 264730001217 Staphylococcal nuclease homologues; Region: SNc; smart00318 264730001218 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 264730001219 Catalytic site; other site 264730001220 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 264730001221 Malic enzyme, N-terminal domain; Region: malic; pfam00390 264730001222 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 264730001223 putative NAD(P) binding site [chemical binding]; other site 264730001224 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 264730001225 Transglycosylase; Region: Transgly; pfam00912 264730001226 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264730001227 Competence protein A; Region: Competence_A; pfam11104 264730001228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 264730001229 nucleotide binding site [chemical binding]; other site 264730001230 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 264730001231 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 264730001232 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 264730001233 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 264730001234 Pilus assembly protein, PilP; Region: PilP; pfam04351 264730001235 AMIN domain; Region: AMIN; pfam11741 264730001236 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 264730001237 Secretin and TonB N terminus short domain; Region: STN; smart00965 264730001238 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264730001239 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264730001240 shikimate kinase; Reviewed; Region: aroK; PRK00131 264730001241 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 264730001242 ADP binding site [chemical binding]; other site 264730001243 magnesium binding site [ion binding]; other site 264730001244 putative shikimate binding site; other site 264730001245 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 264730001246 active site 264730001247 dimer interface [polypeptide binding]; other site 264730001248 metal binding site [ion binding]; metal-binding site 264730001249 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 264730001250 Sporulation related domain; Region: SPOR; pfam05036 264730001251 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 264730001252 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 264730001253 active site 264730001254 dimer interface [polypeptide binding]; other site 264730001255 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 264730001256 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 264730001257 active site 264730001258 FMN binding site [chemical binding]; other site 264730001259 substrate binding site [chemical binding]; other site 264730001260 3Fe-4S cluster binding site [ion binding]; other site 264730001261 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 264730001262 domain interface; other site 264730001263 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 264730001264 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264730001265 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730001266 amidase; Provisional; Region: PRK08137 264730001267 Amidase; Region: Amidase; pfam01425 264730001268 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 264730001269 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 264730001270 substrate binding site [chemical binding]; other site 264730001271 active site 264730001272 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 264730001273 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 264730001274 active site 264730001275 putative substrate binding pocket [chemical binding]; other site 264730001276 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264730001277 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264730001278 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264730001279 putative active site [active] 264730001280 fructuronate transporter; Provisional; Region: PRK10034; cl15264 264730001281 GntP family permease; Region: GntP_permease; pfam02447 264730001282 TIGR02646 family protein; Region: TIGR02646 264730001283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730001284 AAA domain; Region: AAA_21; pfam13304 264730001285 Walker A/P-loop; other site 264730001286 ATP binding site [chemical binding]; other site 264730001287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730001288 putative substrate translocation pore; other site 264730001289 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264730001290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730001291 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264730001292 dimerization interface [polypeptide binding]; other site 264730001293 substrate binding pocket [chemical binding]; other site 264730001294 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 264730001295 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264730001296 dimer interface [polypeptide binding]; other site 264730001297 active site 264730001298 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264730001299 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 264730001300 NAD(P) binding site [chemical binding]; other site 264730001301 homotetramer interface [polypeptide binding]; other site 264730001302 homodimer interface [polypeptide binding]; other site 264730001303 active site 264730001304 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 264730001305 putative active site 1 [active] 264730001306 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 264730001307 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264730001308 dimer interface [polypeptide binding]; other site 264730001309 active site 264730001310 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264730001311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730001312 S-adenosylmethionine binding site [chemical binding]; other site 264730001313 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 264730001314 Predicted exporter [General function prediction only]; Region: COG4258 264730001315 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 264730001316 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264730001317 active site 264730001318 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 264730001319 active sites [active] 264730001320 tetramer interface [polypeptide binding]; other site 264730001321 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 264730001322 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264730001323 putative acyl-acceptor binding pocket; other site 264730001324 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 264730001325 Ligand binding site; other site 264730001326 Putative Catalytic site; other site 264730001327 DXD motif; other site 264730001328 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264730001329 AMP-binding enzyme; Region: AMP-binding; pfam00501 264730001330 acyl-activating enzyme (AAE) consensus motif; other site 264730001331 AMP binding site [chemical binding]; other site 264730001332 active site 264730001333 CoA binding site [chemical binding]; other site 264730001334 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 264730001335 active site 2 [active] 264730001336 dimer interface [polypeptide binding]; other site 264730001337 active site 1 [active] 264730001338 Predicted membrane protein [Function unknown]; Region: COG4648 264730001339 acyl carrier protein; Provisional; Region: PRK05350 264730001340 Phosphopantetheine attachment site; Region: PP-binding; cl09936 264730001341 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264730001342 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264730001343 putative acyl-acceptor binding pocket; other site 264730001344 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 264730001345 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264730001346 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264730001347 P-loop; other site 264730001348 Magnesium ion binding site [ion binding]; other site 264730001349 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264730001350 Magnesium ion binding site [ion binding]; other site 264730001351 PAAR motif; Region: PAAR_motif; pfam05488 264730001352 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 264730001353 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 264730001354 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 264730001355 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 264730001356 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 264730001357 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 264730001358 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 264730001359 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 264730001360 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264730001361 Malonate transporter MadL subunit; Region: MadL; cl04273 264730001362 malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808 264730001363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730001364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730001365 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 264730001366 putative dimerization interface [polypeptide binding]; other site 264730001367 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 264730001368 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 264730001369 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 264730001370 RNA methyltransferase, RsmE family; Region: TIGR00046 264730001371 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 264730001372 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730001373 inhibitor-cofactor binding pocket; inhibition site 264730001374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730001375 catalytic residue [active] 264730001376 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 264730001377 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 264730001378 hypothetical protein; Provisional; Region: PRK03757 264730001379 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 264730001380 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264730001381 ATP binding site [chemical binding]; other site 264730001382 Mg++ binding site [ion binding]; other site 264730001383 motif III; other site 264730001384 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730001385 nucleotide binding region [chemical binding]; other site 264730001386 ATP-binding site [chemical binding]; other site 264730001387 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 264730001388 FAD binding site [chemical binding]; other site 264730001389 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 264730001390 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 264730001391 homotetramer interface [polypeptide binding]; other site 264730001392 ligand binding site [chemical binding]; other site 264730001393 catalytic site [active] 264730001394 NAD binding site [chemical binding]; other site 264730001395 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 264730001396 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 264730001397 fructuronate transporter; Provisional; Region: PRK10034; cl15264 264730001398 GntP family permease; Region: GntP_permease; pfam02447 264730001399 putative aldolase; Validated; Region: PRK08130 264730001400 intersubunit interface [polypeptide binding]; other site 264730001401 active site 264730001402 Zn2+ binding site [ion binding]; other site 264730001403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 264730001404 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264730001405 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264730001406 Flagellin N-methylase; Region: FliB; pfam03692 264730001407 aminotransferase; Validated; Region: PRK08175 264730001408 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730001409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730001410 homodimer interface [polypeptide binding]; other site 264730001411 catalytic residue [active] 264730001412 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 264730001413 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 264730001414 HemN family oxidoreductase; Provisional; Region: PRK05660 264730001415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730001416 FeS/SAM binding site; other site 264730001417 HemN C-terminal domain; Region: HemN_C; pfam06969 264730001418 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 264730001419 active site 264730001420 dimerization interface [polypeptide binding]; other site 264730001421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730001422 S-adenosylmethionine binding site [chemical binding]; other site 264730001423 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 264730001424 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 264730001425 YGGT family; Region: YGGT; pfam02325 264730001426 YGGT family; Region: YGGT; pfam02325 264730001427 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 264730001428 pyrroline-5-carboxylate reductase; Region: PLN02688 264730001429 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 264730001430 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264730001431 catalytic residue [active] 264730001432 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 264730001433 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 264730001434 Walker A motif; other site 264730001435 ATP binding site [chemical binding]; other site 264730001436 Walker B motif; other site 264730001437 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 264730001438 NlpC/P60 family; Region: NLPC_P60; pfam00877 264730001439 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 264730001440 TM2 domain; Region: TM2; cl00984 264730001441 dihydroorotase; Validated; Region: pyrC; PRK09357 264730001442 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264730001443 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 264730001444 active site 264730001445 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 264730001446 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264730001447 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264730001448 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 264730001449 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264730001450 active site 264730001451 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 264730001452 hypothetical protein; Validated; Region: PRK00228 264730001453 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264730001454 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264730001455 glutathione synthetase; Provisional; Region: PRK05246 264730001456 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 264730001457 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 264730001458 Response regulator receiver domain; Region: Response_reg; pfam00072 264730001459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730001460 active site 264730001461 phosphorylation site [posttranslational modification] 264730001462 intermolecular recognition site; other site 264730001463 dimerization interface [polypeptide binding]; other site 264730001464 Response regulator receiver domain; Region: Response_reg; pfam00072 264730001465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730001466 active site 264730001467 phosphorylation site [posttranslational modification] 264730001468 intermolecular recognition site; other site 264730001469 dimerization interface [polypeptide binding]; other site 264730001470 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264730001471 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 264730001472 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730001473 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730001474 dimer interface [polypeptide binding]; other site 264730001475 putative CheW interface [polypeptide binding]; other site 264730001476 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264730001477 putative binding surface; other site 264730001478 active site 264730001479 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264730001480 putative binding surface; other site 264730001481 active site 264730001482 Hpt domain; Region: Hpt; pfam01627 264730001483 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 264730001484 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264730001485 putative binding surface; other site 264730001486 active site 264730001487 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264730001488 putative binding surface; other site 264730001489 active site 264730001490 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 264730001491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730001492 ATP binding site [chemical binding]; other site 264730001493 Mg2+ binding site [ion binding]; other site 264730001494 G-X-G motif; other site 264730001495 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264730001496 Response regulator receiver domain; Region: Response_reg; pfam00072 264730001497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730001498 active site 264730001499 phosphorylation site [posttranslational modification] 264730001500 intermolecular recognition site; other site 264730001501 dimerization interface [polypeptide binding]; other site 264730001502 CheW-like domain; Region: CheW; pfam01584 264730001503 Uncharacterized conserved protein [Function unknown]; Region: COG0397 264730001504 hypothetical protein; Validated; Region: PRK00029 264730001505 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264730001506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730001507 DNA-binding site [nucleotide binding]; DNA binding site 264730001508 FCD domain; Region: FCD; pfam07729 264730001509 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 264730001510 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 264730001511 putative active site [active] 264730001512 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 264730001513 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 264730001514 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 264730001515 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 264730001516 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264730001517 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 264730001518 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264730001519 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264730001520 carboxyltransferase (CT) interaction site; other site 264730001521 biotinylation site [posttranslational modification]; other site 264730001522 hypothetical protein; Provisional; Region: PRK11281 264730001523 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 264730001524 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264730001525 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 264730001526 TrkA-C domain; Region: TrkA_C; pfam02080 264730001527 Transporter associated domain; Region: CorC_HlyC; smart01091 264730001528 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264730001529 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264730001530 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264730001531 active site 264730001532 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264730001533 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 264730001534 Predicted transcriptional regulator [Transcription]; Region: COG3905 264730001535 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 264730001536 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 264730001537 Glutamate binding site [chemical binding]; other site 264730001538 NAD binding site [chemical binding]; other site 264730001539 catalytic residues [active] 264730001540 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264730001541 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 264730001542 Na binding site [ion binding]; other site 264730001543 Alginate lyase; Region: Alginate_lyase2; pfam08787 264730001544 Response regulator receiver domain; Region: Response_reg; pfam00072 264730001545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730001546 active site 264730001547 phosphorylation site [posttranslational modification] 264730001548 intermolecular recognition site; other site 264730001549 dimerization interface [polypeptide binding]; other site 264730001550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730001551 PAS domain; Region: PAS_9; pfam13426 264730001552 putative active site [active] 264730001553 heme pocket [chemical binding]; other site 264730001554 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730001555 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730001556 metal binding site [ion binding]; metal-binding site 264730001557 active site 264730001558 I-site; other site 264730001559 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730001560 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 264730001561 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 264730001562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730001563 Coenzyme A binding pocket [chemical binding]; other site 264730001564 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730001565 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730001566 substrate binding pocket [chemical binding]; other site 264730001567 membrane-bound complex binding site; other site 264730001568 hinge residues; other site 264730001569 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 264730001570 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 264730001571 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264730001572 HI0933-like protein; Region: HI0933_like; pfam03486 264730001573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730001574 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 264730001575 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264730001576 ATP binding site [chemical binding]; other site 264730001577 Mg++ binding site [ion binding]; other site 264730001578 motif III; other site 264730001579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730001580 nucleotide binding region [chemical binding]; other site 264730001581 ATP-binding site [chemical binding]; other site 264730001582 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 264730001583 putative RNA binding site [nucleotide binding]; other site 264730001584 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 264730001585 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264730001586 E3 interaction surface; other site 264730001587 lipoyl attachment site [posttranslational modification]; other site 264730001588 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264730001589 E3 interaction surface; other site 264730001590 lipoyl attachment site [posttranslational modification]; other site 264730001591 e3 binding domain; Region: E3_binding; pfam02817 264730001592 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 264730001593 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 264730001594 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 264730001595 dimer interface [polypeptide binding]; other site 264730001596 TPP-binding site [chemical binding]; other site 264730001597 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 264730001598 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264730001599 metal binding triad; other site 264730001600 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264730001601 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264730001602 metal binding triad; other site 264730001603 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264730001604 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264730001605 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264730001606 putative active site [active] 264730001607 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264730001608 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264730001609 putative active site [active] 264730001610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730001611 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264730001612 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 264730001613 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 264730001614 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 264730001615 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 264730001616 active site 264730001617 ATP binding site [chemical binding]; other site 264730001618 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 264730001619 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 264730001620 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 264730001621 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 264730001622 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 264730001623 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 264730001624 putative ADP-binding pocket [chemical binding]; other site 264730001625 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730001626 Mig-14; Region: Mig-14; pfam07395 264730001627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 264730001628 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 264730001629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730001630 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 264730001631 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 264730001632 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730001633 active site 264730001634 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 264730001635 active site 264730001636 ATP binding site [chemical binding]; other site 264730001637 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 264730001638 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730001639 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 264730001640 Walker A/P-loop; other site 264730001641 ATP binding site [chemical binding]; other site 264730001642 Q-loop/lid; other site 264730001643 ABC transporter signature motif; other site 264730001644 Walker B; other site 264730001645 D-loop; other site 264730001646 H-loop/switch region; other site 264730001647 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 264730001648 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 264730001649 putative ribose interaction site [chemical binding]; other site 264730001650 putative ADP binding site [chemical binding]; other site 264730001651 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 264730001652 active site 264730001653 nucleotide binding site [chemical binding]; other site 264730001654 HIGH motif; other site 264730001655 KMSKS motif; other site 264730001656 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264730001657 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264730001658 active site 264730001659 catalytic tetrad [active] 264730001660 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 264730001661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730001662 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 264730001663 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 264730001664 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 264730001665 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264730001666 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264730001667 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 264730001668 ThiC-associated domain; Region: ThiC-associated; pfam13667 264730001669 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 264730001670 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264730001671 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264730001672 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 264730001673 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 264730001674 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 264730001675 dimer interface [polypeptide binding]; other site 264730001676 ADP-ribose binding site [chemical binding]; other site 264730001677 active site 264730001678 nudix motif; other site 264730001679 metal binding site [ion binding]; metal-binding site 264730001680 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 264730001681 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 264730001682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264730001683 active site 264730001684 metal binding site [ion binding]; metal-binding site 264730001685 hexamer interface [polypeptide binding]; other site 264730001686 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 264730001687 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730001688 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 264730001689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730001690 ATP binding site [chemical binding]; other site 264730001691 Mg2+ binding site [ion binding]; other site 264730001692 G-X-G motif; other site 264730001693 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264730001694 anchoring element; other site 264730001695 dimer interface [polypeptide binding]; other site 264730001696 ATP binding site [chemical binding]; other site 264730001697 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 264730001698 active site 264730001699 metal binding site [ion binding]; metal-binding site 264730001700 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264730001701 SdiA-regulated; Region: SdiA-regulated; cd09971 264730001702 putative active site [active] 264730001703 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 264730001704 catalytic motif [active] 264730001705 Catalytic residue [active] 264730001706 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 264730001707 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 264730001708 CAP-like domain; other site 264730001709 active site 264730001710 primary dimer interface [polypeptide binding]; other site 264730001711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 264730001712 Protein of unknown function (DUF330); Region: DUF330; pfam03886 264730001713 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 264730001714 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 264730001715 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 264730001716 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 264730001717 phosphoserine phosphatase SerB; Region: serB; TIGR00338 264730001718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730001719 motif II; other site 264730001720 bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional; Region: PRK09629 264730001721 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 264730001722 active site residue [active] 264730001723 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 264730001724 active site residue [active] 264730001725 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 264730001726 HDOD domain; Region: HDOD; pfam08668 264730001727 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 264730001728 flagellar motor protein MotA; Validated; Region: PRK09110 264730001729 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 264730001730 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 264730001731 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730001732 ligand binding site [chemical binding]; other site 264730001733 GTPase RsgA; Reviewed; Region: PRK12288 264730001734 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264730001735 RNA binding site [nucleotide binding]; other site 264730001736 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 264730001737 GTPase/Zn-binding domain interface [polypeptide binding]; other site 264730001738 GTP/Mg2+ binding site [chemical binding]; other site 264730001739 G4 box; other site 264730001740 G5 box; other site 264730001741 G1 box; other site 264730001742 Switch I region; other site 264730001743 G2 box; other site 264730001744 G3 box; other site 264730001745 Switch II region; other site 264730001746 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 264730001747 catalytic site [active] 264730001748 putative active site [active] 264730001749 putative substrate binding site [chemical binding]; other site 264730001750 dimer interface [polypeptide binding]; other site 264730001751 Predicted membrane protein [Function unknown]; Region: COG2860 264730001752 UPF0126 domain; Region: UPF0126; pfam03458 264730001753 UPF0126 domain; Region: UPF0126; pfam03458 264730001754 epoxyqueuosine reductase; Region: TIGR00276 264730001755 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 264730001756 putative carbohydrate kinase; Provisional; Region: PRK10565 264730001757 Uncharacterized conserved protein [Function unknown]; Region: COG0062 264730001758 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 264730001759 putative substrate binding site [chemical binding]; other site 264730001760 putative ATP binding site [chemical binding]; other site 264730001761 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 264730001762 AMIN domain; Region: AMIN; pfam11741 264730001763 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 264730001764 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264730001765 active site 264730001766 metal binding site [ion binding]; metal-binding site 264730001767 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264730001768 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 264730001769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730001770 ATP binding site [chemical binding]; other site 264730001771 Mg2+ binding site [ion binding]; other site 264730001772 G-X-G motif; other site 264730001773 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 264730001774 ATP binding site [chemical binding]; other site 264730001775 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 264730001776 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 264730001777 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 264730001778 bacterial Hfq-like; Region: Hfq; cd01716 264730001779 hexamer interface [polypeptide binding]; other site 264730001780 Sm1 motif; other site 264730001781 RNA binding site [nucleotide binding]; other site 264730001782 Sm2 motif; other site 264730001783 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 264730001784 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 264730001785 HflX GTPase family; Region: HflX; cd01878 264730001786 G1 box; other site 264730001787 GTP/Mg2+ binding site [chemical binding]; other site 264730001788 Switch I region; other site 264730001789 G2 box; other site 264730001790 G3 box; other site 264730001791 Switch II region; other site 264730001792 G4 box; other site 264730001793 G5 box; other site 264730001794 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 264730001795 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 264730001796 HflK protein; Region: hflK; TIGR01933 264730001797 HflC protein; Region: hflC; TIGR01932 264730001798 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 264730001799 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 264730001800 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 264730001801 dimer interface [polypeptide binding]; other site 264730001802 motif 1; other site 264730001803 active site 264730001804 motif 2; other site 264730001805 motif 3; other site 264730001806 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 264730001807 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 264730001808 GDP-binding site [chemical binding]; other site 264730001809 ACT binding site; other site 264730001810 IMP binding site; other site 264730001811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730001812 dimerization interface [polypeptide binding]; other site 264730001813 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730001814 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730001815 dimer interface [polypeptide binding]; other site 264730001816 putative CheW interface [polypeptide binding]; other site 264730001817 ribonuclease R; Region: RNase_R; TIGR02063 264730001818 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 264730001819 RNB domain; Region: RNB; pfam00773 264730001820 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 264730001821 RNA binding site [nucleotide binding]; other site 264730001822 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 264730001823 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 264730001824 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264730001825 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 264730001826 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 264730001827 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 264730001828 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 264730001829 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 264730001830 replicative DNA helicase; Provisional; Region: PRK05748 264730001831 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 264730001832 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 264730001833 Walker A motif; other site 264730001834 ATP binding site [chemical binding]; other site 264730001835 Walker B motif; other site 264730001836 DNA binding loops [nucleotide binding] 264730001837 hypothetical protein; Provisional; Region: PRK01254 264730001838 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 264730001839 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 264730001840 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 264730001841 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264730001842 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264730001843 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 264730001844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 264730001845 Uncharacterized conserved protein [Function unknown]; Region: COG2308 264730001846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 264730001847 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 264730001848 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264730001849 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 264730001850 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264730001851 azurin; Region: azurin; TIGR02695 264730001852 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 264730001853 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 264730001854 homodimer interface [polypeptide binding]; other site 264730001855 NAD binding pocket [chemical binding]; other site 264730001856 ATP binding pocket [chemical binding]; other site 264730001857 Mg binding site [ion binding]; other site 264730001858 active-site loop [active] 264730001859 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 264730001860 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 264730001861 active site 264730001862 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264730001863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730001864 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730001865 dimerization interface [polypeptide binding]; other site 264730001866 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264730001867 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264730001868 dimerization interface [polypeptide binding]; other site 264730001869 ligand binding site [chemical binding]; other site 264730001870 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730001871 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264730001872 TM-ABC transporter signature motif; other site 264730001873 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 264730001874 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 264730001875 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264730001876 TM-ABC transporter signature motif; other site 264730001877 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 264730001878 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264730001879 Walker A/P-loop; other site 264730001880 ATP binding site [chemical binding]; other site 264730001881 Q-loop/lid; other site 264730001882 ABC transporter signature motif; other site 264730001883 Walker B; other site 264730001884 D-loop; other site 264730001885 H-loop/switch region; other site 264730001886 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264730001887 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264730001888 Walker A/P-loop; other site 264730001889 ATP binding site [chemical binding]; other site 264730001890 Q-loop/lid; other site 264730001891 ABC transporter signature motif; other site 264730001892 Walker B; other site 264730001893 D-loop; other site 264730001894 H-loop/switch region; other site 264730001895 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264730001896 trimer interface [polypeptide binding]; other site 264730001897 active site 264730001898 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 264730001899 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 264730001900 putative NAD(P) binding site [chemical binding]; other site 264730001901 homotetramer interface [polypeptide binding]; other site 264730001902 homodimer interface [polypeptide binding]; other site 264730001903 active site 264730001904 dimerization interface [polypeptide binding]; other site 264730001905 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 264730001906 putative active cleft [active] 264730001907 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 264730001908 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 264730001909 TPP-binding site; other site 264730001910 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264730001911 PYR/PP interface [polypeptide binding]; other site 264730001912 dimer interface [polypeptide binding]; other site 264730001913 TPP binding site [chemical binding]; other site 264730001914 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264730001915 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264730001916 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264730001917 substrate binding pocket [chemical binding]; other site 264730001918 chain length determination region; other site 264730001919 substrate-Mg2+ binding site; other site 264730001920 catalytic residues [active] 264730001921 aspartate-rich region 1; other site 264730001922 active site lid residues [active] 264730001923 aspartate-rich region 2; other site 264730001924 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 264730001925 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 264730001926 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264730001927 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730001928 catalytic residue [active] 264730001929 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 264730001930 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264730001931 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264730001932 putative S-transferase; Provisional; Region: PRK11752 264730001933 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 264730001934 C-terminal domain interface [polypeptide binding]; other site 264730001935 GSH binding site (G-site) [chemical binding]; other site 264730001936 dimer interface [polypeptide binding]; other site 264730001937 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 264730001938 dimer interface [polypeptide binding]; other site 264730001939 N-terminal domain interface [polypeptide binding]; other site 264730001940 active site 264730001941 ABC-2 type transporter; Region: ABC2_membrane; cl17235 264730001942 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730001943 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730001944 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730001945 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 264730001946 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 264730001947 active site 264730001948 NTP binding site [chemical binding]; other site 264730001949 metal binding triad [ion binding]; metal-binding site 264730001950 Methyltransferase domain; Region: Methyltransf_26; pfam13659 264730001951 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730001952 MULE transposase domain; Region: MULE; pfam10551 264730001953 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 264730001954 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 264730001955 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264730001956 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 264730001957 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730001958 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264730001959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730001960 DNA binding residues [nucleotide binding] 264730001961 DNA primase, catalytic core; Region: dnaG; TIGR01391 264730001962 CHC2 zinc finger; Region: zf-CHC2; pfam01807 264730001963 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 264730001964 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 264730001965 active site 264730001966 metal binding site [ion binding]; metal-binding site 264730001967 interdomain interaction site; other site 264730001968 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 264730001969 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 264730001970 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 264730001971 UGMP family protein; Validated; Region: PRK09604 264730001972 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 264730001973 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 264730001974 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 264730001975 homooctamer interface [polypeptide binding]; other site 264730001976 active site 264730001977 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 264730001978 catalytic center binding site [active] 264730001979 ATP binding site [chemical binding]; other site 264730001980 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 264730001981 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264730001982 active site 264730001983 NTP binding site [chemical binding]; other site 264730001984 metal binding triad [ion binding]; metal-binding site 264730001985 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264730001986 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264730001987 Zn2+ binding site [ion binding]; other site 264730001988 Mg2+ binding site [ion binding]; other site 264730001989 SpoVR family protein; Provisional; Region: PRK11767 264730001990 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 264730001991 hypothetical protein; Provisional; Region: PRK05325 264730001992 PrkA family serine protein kinase; Provisional; Region: PRK15455 264730001993 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 264730001994 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 264730001995 active site residue [active] 264730001996 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 264730001997 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 264730001998 active site 264730001999 metal binding site [ion binding]; metal-binding site 264730002000 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 264730002001 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 264730002002 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 264730002003 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 264730002004 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 264730002005 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 264730002006 SurA N-terminal domain; Region: SurA_N; pfam09312 264730002007 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264730002008 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264730002009 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 264730002010 OstA-like protein; Region: OstA; cl00844 264730002011 Organic solvent tolerance protein; Region: OstA_C; pfam04453 264730002012 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 264730002013 Phosphotransferase enzyme family; Region: APH; pfam01636 264730002014 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264730002015 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 264730002016 Substrate binding site; other site 264730002017 metal-binding site 264730002018 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 264730002019 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 264730002020 putative metal binding site [ion binding]; other site 264730002021 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264730002022 HSP70 interaction site [polypeptide binding]; other site 264730002023 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 264730002024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730002025 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730002026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730002027 substrate binding pocket [chemical binding]; other site 264730002028 membrane-bound complex binding site; other site 264730002029 hinge residues; other site 264730002030 PAS domain; Region: PAS_9; pfam13426 264730002031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730002032 putative active site [active] 264730002033 heme pocket [chemical binding]; other site 264730002034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264730002035 Histidine kinase; Region: HisKA_3; pfam07730 264730002036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730002037 ATP binding site [chemical binding]; other site 264730002038 Mg2+ binding site [ion binding]; other site 264730002039 G-X-G motif; other site 264730002040 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730002041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730002042 active site 264730002043 phosphorylation site [posttranslational modification] 264730002044 intermolecular recognition site; other site 264730002045 dimerization interface [polypeptide binding]; other site 264730002046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730002047 DNA binding residues [nucleotide binding] 264730002048 dimerization interface [polypeptide binding]; other site 264730002049 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 264730002050 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 264730002051 Walker A/P-loop; other site 264730002052 ATP binding site [chemical binding]; other site 264730002053 Q-loop/lid; other site 264730002054 ABC transporter signature motif; other site 264730002055 Walker B; other site 264730002056 D-loop; other site 264730002057 H-loop/switch region; other site 264730002058 TOBE domain; Region: TOBE_2; pfam08402 264730002059 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 264730002060 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 264730002061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730002062 dimer interface [polypeptide binding]; other site 264730002063 conserved gate region; other site 264730002064 putative PBP binding loops; other site 264730002065 ABC-ATPase subunit interface; other site 264730002066 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264730002067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730002068 dimer interface [polypeptide binding]; other site 264730002069 conserved gate region; other site 264730002070 putative PBP binding loops; other site 264730002071 ABC-ATPase subunit interface; other site 264730002072 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 264730002073 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 264730002074 substrate binding site [chemical binding]; other site 264730002075 hexamer interface [polypeptide binding]; other site 264730002076 metal binding site [ion binding]; metal-binding site 264730002077 phosphoglycolate phosphatase; Provisional; Region: PRK13223 264730002078 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264730002079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730002080 motif II; other site 264730002081 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 264730002082 anthranilate synthase component I; Provisional; Region: PRK13565 264730002083 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 264730002084 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 264730002085 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 264730002086 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 264730002087 active site 264730002088 catalytic triad [active] 264730002089 oxyanion hole [active] 264730002090 Autotransporter beta-domain; Region: Autotransporter; pfam03797 264730002091 lysogenic prophage region; PHAGE01 264730002092 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 264730002093 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 264730002094 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730002095 non-specific DNA binding site [nucleotide binding]; other site 264730002096 salt bridge; other site 264730002097 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 264730002098 sequence-specific DNA binding site [nucleotide binding]; other site 264730002099 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264730002100 Catalytic site [active] 264730002101 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 264730002102 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 264730002103 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 264730002104 Phage tail tube protein; Region: Tail_tube; pfam10618 264730002105 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 264730002106 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 264730002107 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 264730002108 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 264730002109 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 264730002110 Predicted chitinase [General function prediction only]; Region: COG3179 264730002111 catalytic residue [active] 264730002112 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 264730002113 integrase; Provisional; Region: PRK09692 264730002114 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 264730002115 active site 264730002116 Int/Topo IB signature motif; other site 264730002117 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 264730002118 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264730002119 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 264730002120 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 264730002121 DNA binding site [nucleotide binding] 264730002122 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 264730002123 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 264730002124 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 264730002125 glutamine binding [chemical binding]; other site 264730002126 catalytic triad [active] 264730002127 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 264730002128 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264730002129 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264730002130 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 264730002131 active site 264730002132 ribulose/triose binding site [chemical binding]; other site 264730002133 phosphate binding site [ion binding]; other site 264730002134 substrate (anthranilate) binding pocket [chemical binding]; other site 264730002135 product (indole) binding pocket [chemical binding]; other site 264730002136 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 264730002137 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 264730002138 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264730002139 ligand binding site [chemical binding]; other site 264730002140 flexible hinge region; other site 264730002141 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264730002142 putative switch regulator; other site 264730002143 non-specific DNA interactions [nucleotide binding]; other site 264730002144 DNA binding site [nucleotide binding] 264730002145 sequence specific DNA binding site [nucleotide binding]; other site 264730002146 putative cAMP binding site [chemical binding]; other site 264730002147 OsmC-like protein; Region: OsmC; cl00767 264730002148 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 264730002149 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 264730002150 diiron binding motif [ion binding]; other site 264730002151 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 264730002152 nucleotide binding site/active site [active] 264730002153 HIT family signature motif; other site 264730002154 catalytic residue [active] 264730002155 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264730002156 classical (c) SDRs; Region: SDR_c; cd05233 264730002157 NAD(P) binding site [chemical binding]; other site 264730002158 active site 264730002159 Protein of unknown function (DUF805); Region: DUF805; pfam05656 264730002160 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 264730002161 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 264730002162 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264730002163 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 264730002164 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 264730002165 putative peptidase; Provisional; Region: PRK11649 264730002166 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 264730002167 Peptidase family M23; Region: Peptidase_M23; pfam01551 264730002168 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 264730002169 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 264730002170 active site 264730002171 HIGH motif; other site 264730002172 dimer interface [polypeptide binding]; other site 264730002173 KMSKS motif; other site 264730002174 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 264730002175 RNA binding surface [nucleotide binding]; other site 264730002176 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 264730002177 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 264730002178 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 264730002179 Family description; Region: UvrD_C_2; pfam13538 264730002180 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 264730002181 AAA domain; Region: AAA_30; pfam13604 264730002182 Family description; Region: UvrD_C_2; pfam13538 264730002183 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 264730002184 nudix motif; other site 264730002185 PAAR motif; Region: PAAR_motif; pfam05488 264730002186 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730002187 MULE transposase domain; Region: MULE; pfam10551 264730002188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 264730002189 Integrase core domain; Region: rve; pfam00665 264730002190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730002191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730002192 LysR substrate binding domain; Region: LysR_substrate; pfam03466 264730002193 dimerization interface [polypeptide binding]; other site 264730002194 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 264730002195 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 264730002196 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 264730002197 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 264730002198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264730002199 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 264730002200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730002201 dimer interface [polypeptide binding]; other site 264730002202 conserved gate region; other site 264730002203 putative PBP binding loops; other site 264730002204 ABC-ATPase subunit interface; other site 264730002205 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 264730002206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730002207 Walker A/P-loop; other site 264730002208 ATP binding site [chemical binding]; other site 264730002209 Q-loop/lid; other site 264730002210 ABC transporter signature motif; other site 264730002211 Walker B; other site 264730002212 D-loop; other site 264730002213 H-loop/switch region; other site 264730002214 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 264730002215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730002216 substrate binding pocket [chemical binding]; other site 264730002217 membrane-bound complex binding site; other site 264730002218 hinge residues; other site 264730002219 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 264730002220 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 264730002221 active site residue [active] 264730002222 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 264730002223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730002224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730002225 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730002226 dimerization interface [polypeptide binding]; other site 264730002227 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264730002228 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264730002229 substrate binding pocket [chemical binding]; other site 264730002230 chain length determination region; other site 264730002231 substrate-Mg2+ binding site; other site 264730002232 catalytic residues [active] 264730002233 aspartate-rich region 1; other site 264730002234 active site lid residues [active] 264730002235 aspartate-rich region 2; other site 264730002236 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 264730002237 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 264730002238 GTPase CgtA; Reviewed; Region: obgE; PRK12298 264730002239 GTP1/OBG; Region: GTP1_OBG; pfam01018 264730002240 Obg GTPase; Region: Obg; cd01898 264730002241 G1 box; other site 264730002242 GTP/Mg2+ binding site [chemical binding]; other site 264730002243 Switch I region; other site 264730002244 G2 box; other site 264730002245 G3 box; other site 264730002246 Switch II region; other site 264730002247 G4 box; other site 264730002248 G5 box; other site 264730002249 gamma-glutamyl kinase; Provisional; Region: PRK05429 264730002250 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 264730002251 nucleotide binding site [chemical binding]; other site 264730002252 homotetrameric interface [polypeptide binding]; other site 264730002253 putative phosphate binding site [ion binding]; other site 264730002254 putative allosteric binding site; other site 264730002255 PUA domain; Region: PUA; pfam01472 264730002256 CreA protein; Region: CreA; pfam05981 264730002257 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 264730002258 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 264730002259 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 264730002260 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 264730002261 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 264730002262 active site 264730002263 Riboflavin kinase; Region: Flavokinase; smart00904 264730002264 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 264730002265 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264730002266 active site 264730002267 HIGH motif; other site 264730002268 nucleotide binding site [chemical binding]; other site 264730002269 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264730002270 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 264730002271 active site 264730002272 KMSKS motif; other site 264730002273 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 264730002274 tRNA binding surface [nucleotide binding]; other site 264730002275 anticodon binding site; other site 264730002276 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264730002277 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 264730002278 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 264730002279 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264730002280 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 264730002281 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 264730002282 Type II transport protein GspH; Region: GspH; pfam12019 264730002283 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 264730002284 Type II transport protein GspH; Region: GspH; pfam12019 264730002285 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 264730002286 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 264730002287 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 264730002288 PilX N-terminal; Region: PilX_N; pfam14341 264730002289 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 264730002290 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 264730002291 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 264730002292 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264730002293 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264730002294 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264730002295 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730002296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730002297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730002298 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264730002299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730002300 active site 264730002301 phosphorylation site [posttranslational modification] 264730002302 intermolecular recognition site; other site 264730002303 dimerization interface [polypeptide binding]; other site 264730002304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730002305 Walker A motif; other site 264730002306 ATP binding site [chemical binding]; other site 264730002307 Walker B motif; other site 264730002308 arginine finger; other site 264730002309 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730002310 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264730002311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730002312 dimer interface [polypeptide binding]; other site 264730002313 phosphorylation site [posttranslational modification] 264730002314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730002315 ATP binding site [chemical binding]; other site 264730002316 Mg2+ binding site [ion binding]; other site 264730002317 G-X-G motif; other site 264730002318 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 264730002319 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 264730002320 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 264730002321 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264730002322 RNA binding surface [nucleotide binding]; other site 264730002323 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264730002324 active site 264730002325 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 264730002326 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 264730002327 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 264730002328 Clp amino terminal domain; Region: Clp_N; pfam02861 264730002329 Clp amino terminal domain; Region: Clp_N; pfam02861 264730002330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730002331 Walker A motif; other site 264730002332 ATP binding site [chemical binding]; other site 264730002333 Walker B motif; other site 264730002334 arginine finger; other site 264730002335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730002336 Walker A motif; other site 264730002337 ATP binding site [chemical binding]; other site 264730002338 Walker B motif; other site 264730002339 arginine finger; other site 264730002340 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264730002341 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264730002342 active site 264730002343 catalytic residues [active] 264730002344 DNA binding site [nucleotide binding] 264730002345 Int/Topo IB signature motif; other site 264730002346 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730002347 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 264730002348 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 264730002349 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 264730002350 active site 264730002351 putative interdomain interaction site [polypeptide binding]; other site 264730002352 putative metal-binding site [ion binding]; other site 264730002353 putative nucleotide binding site [chemical binding]; other site 264730002354 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 264730002355 nucleotide binding region [chemical binding]; other site 264730002356 ATP-binding site [chemical binding]; other site 264730002357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730002358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730002359 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 264730002360 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264730002361 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264730002362 PA14 domain; Region: PA14; pfam07691 264730002363 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264730002364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730002365 Coenzyme A binding pocket [chemical binding]; other site 264730002366 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 264730002367 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730002368 active site 264730002369 DNA binding site [nucleotide binding] 264730002370 Int/Topo IB signature motif; other site 264730002371 PilM; Region: PilM; pfam07419 264730002372 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 264730002373 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 264730002374 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 264730002375 lytic murein transglycosylase; Region: MltB_2; TIGR02283 264730002376 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264730002377 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264730002378 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 264730002379 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 264730002380 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 264730002381 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 264730002382 catalytic residues [active] 264730002383 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730002384 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730002385 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730002386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730002387 dimer interface [polypeptide binding]; other site 264730002388 phosphorylation site [posttranslational modification] 264730002389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730002390 ATP binding site [chemical binding]; other site 264730002391 Mg2+ binding site [ion binding]; other site 264730002392 G-X-G motif; other site 264730002393 Response regulator receiver domain; Region: Response_reg; pfam00072 264730002394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730002395 active site 264730002396 phosphorylation site [posttranslational modification] 264730002397 intermolecular recognition site; other site 264730002398 dimerization interface [polypeptide binding]; other site 264730002399 Hpt domain; Region: Hpt; pfam01627 264730002400 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730002401 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524 264730002402 putative fimbrial protein TcfA; Provisional; Region: PRK15308 264730002403 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730002404 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730002405 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730002406 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730002407 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730002408 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730002409 substrate binding pocket [chemical binding]; other site 264730002410 membrane-bound complex binding site; other site 264730002411 hinge residues; other site 264730002412 PAS fold; Region: PAS; pfam00989 264730002413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730002414 putative active site [active] 264730002415 heme pocket [chemical binding]; other site 264730002416 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730002417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730002418 active site 264730002419 phosphorylation site [posttranslational modification] 264730002420 intermolecular recognition site; other site 264730002421 dimerization interface [polypeptide binding]; other site 264730002422 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730002423 DNA binding residues [nucleotide binding] 264730002424 dimerization interface [polypeptide binding]; other site 264730002425 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 264730002426 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 264730002427 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 264730002428 haemagglutination activity domain; Region: Haemagg_act; smart00912 264730002429 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 264730002430 DNA binding site [nucleotide binding] 264730002431 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 264730002432 Avirulence protein; Region: AvrB_AvrC; pfam05394 264730002433 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730002434 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730002435 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730002436 Transposase; Region: HTH_Tnp_1; cl17663 264730002437 putative transposase OrfB; Reviewed; Region: PHA02517 264730002438 HTH-like domain; Region: HTH_21; pfam13276 264730002439 Integrase core domain; Region: rve; pfam00665 264730002440 Integrase core domain; Region: rve_3; pfam13683 264730002441 Autotransporter beta-domain; Region: Autotransporter; pfam03797 264730002442 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 264730002443 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730002444 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730002445 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 264730002446 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 264730002447 putative active site [active] 264730002448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730002449 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 264730002450 Walker A/P-loop; other site 264730002451 ATP binding site [chemical binding]; other site 264730002452 Q-loop/lid; other site 264730002453 ABC transporter signature motif; other site 264730002454 Walker B; other site 264730002455 D-loop; other site 264730002456 H-loop/switch region; other site 264730002457 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264730002458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264730002459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730002460 dimer interface [polypeptide binding]; other site 264730002461 phosphorylation site [posttranslational modification] 264730002462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730002463 ATP binding site [chemical binding]; other site 264730002464 Mg2+ binding site [ion binding]; other site 264730002465 G-X-G motif; other site 264730002466 Response regulator receiver domain; Region: Response_reg; pfam00072 264730002467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730002468 active site 264730002469 phosphorylation site [posttranslational modification] 264730002470 intermolecular recognition site; other site 264730002471 dimerization interface [polypeptide binding]; other site 264730002472 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 264730002473 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 264730002474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730002475 active site 264730002476 phosphorylation site [posttranslational modification] 264730002477 intermolecular recognition site; other site 264730002478 dimerization interface [polypeptide binding]; other site 264730002479 CheB methylesterase; Region: CheB_methylest; pfam01339 264730002480 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13498 264730002481 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264730002482 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 264730002483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730002484 S-adenosylmethionine binding site [chemical binding]; other site 264730002485 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 264730002486 putative CheA interaction surface; other site 264730002487 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730002488 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730002489 dimerization interface [polypeptide binding]; other site 264730002490 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730002491 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730002492 dimer interface [polypeptide binding]; other site 264730002493 putative CheW interface [polypeptide binding]; other site 264730002494 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 264730002495 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264730002496 putative binding surface; other site 264730002497 active site 264730002498 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 264730002499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730002500 ATP binding site [chemical binding]; other site 264730002501 Mg2+ binding site [ion binding]; other site 264730002502 G-X-G motif; other site 264730002503 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 264730002504 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264730002505 anti sigma factor interaction site; other site 264730002506 regulatory phosphorylation site [posttranslational modification]; other site 264730002507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730002508 Response regulator receiver domain; Region: Response_reg; pfam00072 264730002509 active site 264730002510 phosphorylation site [posttranslational modification] 264730002511 intermolecular recognition site; other site 264730002512 dimerization interface [polypeptide binding]; other site 264730002513 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 264730002514 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264730002515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264730002516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 264730002517 MOSC domain; Region: MOSC; pfam03473 264730002518 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 264730002519 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 264730002520 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 264730002521 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 264730002522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730002523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730002524 Walker A/P-loop; other site 264730002525 ATP binding site [chemical binding]; other site 264730002526 Q-loop/lid; other site 264730002527 ABC transporter signature motif; other site 264730002528 Walker B; other site 264730002529 D-loop; other site 264730002530 H-loop/switch region; other site 264730002531 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 264730002532 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730002533 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 264730002534 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002535 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002536 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002537 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002538 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002539 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002540 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002541 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 264730002542 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002543 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002544 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002545 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002546 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002547 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002548 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002549 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002550 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002551 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002552 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002553 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002554 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002555 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002556 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 264730002557 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002558 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002559 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 264730002560 DNA gyrase inhibitor; Reviewed; Region: PRK00418 264730002561 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 264730002562 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 264730002563 CoA-binding site [chemical binding]; other site 264730002564 ATP-binding [chemical binding]; other site 264730002565 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 264730002566 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 264730002567 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 264730002568 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 264730002569 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264730002570 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264730002571 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 264730002572 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 264730002573 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264730002574 Walker A motif; other site 264730002575 ATP binding site [chemical binding]; other site 264730002576 Walker B motif; other site 264730002577 putative major pilin subunit; Provisional; Region: PRK10574 264730002578 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730002579 MULE transposase domain; Region: MULE; pfam10551 264730002580 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 264730002581 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264730002582 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 264730002583 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 264730002584 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 264730002585 putative metal binding site [ion binding]; other site 264730002586 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 264730002587 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264730002588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264730002589 active site 264730002590 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 264730002591 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 264730002592 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 264730002593 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 264730002594 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264730002595 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 264730002596 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 264730002597 putative metal binding site [ion binding]; other site 264730002598 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 264730002599 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 264730002600 putative metal binding site [ion binding]; other site 264730002601 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 264730002602 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 264730002603 putative metal binding site [ion binding]; other site 264730002604 tellurite resistance protein terB; Region: terB; cd07176 264730002605 putative metal binding site [ion binding]; other site 264730002606 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 264730002607 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 264730002608 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 264730002609 putative metal binding site [ion binding]; other site 264730002610 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 264730002611 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 264730002612 putative metal binding site [ion binding]; other site 264730002613 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 264730002614 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 264730002615 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264730002616 metal ion-dependent adhesion site (MIDAS); other site 264730002617 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 264730002618 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 264730002619 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 264730002620 dimerization interface [polypeptide binding]; other site 264730002621 active site 264730002622 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 264730002623 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 264730002624 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264730002625 amidase catalytic site [active] 264730002626 Zn binding residues [ion binding]; other site 264730002627 substrate binding site [chemical binding]; other site 264730002628 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 264730002629 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264730002630 active site 264730002631 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 264730002632 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264730002633 DNA binding site [nucleotide binding] 264730002634 domain linker motif; other site 264730002635 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 264730002636 dimerization interface [polypeptide binding]; other site 264730002637 ligand binding site [chemical binding]; other site 264730002638 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 264730002639 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 264730002640 active site 264730002641 phosphorylation site [posttranslational modification] 264730002642 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 264730002643 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 264730002644 dimerization domain swap beta strand [polypeptide binding]; other site 264730002645 regulatory protein interface [polypeptide binding]; other site 264730002646 active site 264730002647 regulatory phosphorylation site [posttranslational modification]; other site 264730002648 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 264730002649 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 264730002650 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264730002651 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264730002652 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 264730002653 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 264730002654 putative substrate binding site [chemical binding]; other site 264730002655 putative ATP binding site [chemical binding]; other site 264730002656 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 264730002657 active site 264730002658 P-loop; other site 264730002659 phosphorylation site [posttranslational modification] 264730002660 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 264730002661 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 264730002662 active site 264730002663 P-loop; other site 264730002664 phosphorylation site [posttranslational modification] 264730002665 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 264730002666 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 264730002667 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264730002668 dimer interface [polypeptide binding]; other site 264730002669 active site 264730002670 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 264730002671 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 264730002672 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 264730002673 active site 264730002674 dimer interface [polypeptide binding]; other site 264730002675 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 264730002676 dimer interface [polypeptide binding]; other site 264730002677 active site 264730002678 Pantoate-beta-alanine ligase; Region: PanC; cd00560 264730002679 pantoate--beta-alanine ligase; Region: panC; TIGR00018 264730002680 active site 264730002681 ATP-binding site [chemical binding]; other site 264730002682 pantoate-binding site; other site 264730002683 HXXH motif; other site 264730002684 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 264730002685 oligomerization interface [polypeptide binding]; other site 264730002686 active site 264730002687 metal binding site [ion binding]; metal-binding site 264730002688 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 264730002689 catalytic center binding site [active] 264730002690 ATP binding site [chemical binding]; other site 264730002691 poly(A) polymerase; Region: pcnB; TIGR01942 264730002692 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264730002693 active site 264730002694 NTP binding site [chemical binding]; other site 264730002695 metal binding triad [ion binding]; metal-binding site 264730002696 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264730002697 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 264730002698 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264730002699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730002700 active site 264730002701 phosphorylation site [posttranslational modification] 264730002702 intermolecular recognition site; other site 264730002703 dimerization interface [polypeptide binding]; other site 264730002704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730002705 Walker A motif; other site 264730002706 ATP binding site [chemical binding]; other site 264730002707 Walker B motif; other site 264730002708 arginine finger; other site 264730002709 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 264730002710 Na binding site [ion binding]; other site 264730002711 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264730002712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730002713 putative active site [active] 264730002714 heme pocket [chemical binding]; other site 264730002715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730002716 dimer interface [polypeptide binding]; other site 264730002717 phosphorylation site [posttranslational modification] 264730002718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730002719 ATP binding site [chemical binding]; other site 264730002720 Mg2+ binding site [ion binding]; other site 264730002721 G-X-G motif; other site 264730002722 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 264730002723 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 264730002724 active site 264730002725 nucleotide binding site [chemical binding]; other site 264730002726 HIGH motif; other site 264730002727 KMSKS motif; other site 264730002728 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 264730002729 hypothetical protein; Provisional; Region: PRK08960 264730002730 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730002731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730002732 homodimer interface [polypeptide binding]; other site 264730002733 catalytic residue [active] 264730002734 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 264730002735 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 264730002736 iron-sulfur cluster [ion binding]; other site 264730002737 [2Fe-2S] cluster binding site [ion binding]; other site 264730002738 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 264730002739 intersubunit interface [polypeptide binding]; other site 264730002740 active site 264730002741 catalytic residue [active] 264730002742 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 264730002743 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 264730002744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 264730002745 AAA domain; Region: AAA_33; pfam13671 264730002746 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 264730002747 ATP-binding site [chemical binding]; other site 264730002748 Gluconate-6-phosphate binding site [chemical binding]; other site 264730002749 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 264730002750 Transglycosylase; Region: Transgly; pfam00912 264730002751 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264730002752 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264730002753 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 264730002754 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 264730002755 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 264730002756 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264730002757 PYR/PP interface [polypeptide binding]; other site 264730002758 dimer interface [polypeptide binding]; other site 264730002759 TPP binding site [chemical binding]; other site 264730002760 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264730002761 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 264730002762 TPP-binding site [chemical binding]; other site 264730002763 dimer interface [polypeptide binding]; other site 264730002764 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 264730002765 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 264730002766 putative valine binding site [chemical binding]; other site 264730002767 dimer interface [polypeptide binding]; other site 264730002768 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 264730002769 ketol-acid reductoisomerase; Provisional; Region: PRK05479 264730002770 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 264730002771 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 264730002772 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 264730002773 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 264730002774 TMAO/DMSO reductase; Reviewed; Region: PRK05363 264730002775 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 264730002776 Moco binding site; other site 264730002777 metal coordination site [ion binding]; other site 264730002778 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 264730002779 Right handed beta helix region; Region: Beta_helix; pfam13229 264730002780 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 264730002781 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 264730002782 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264730002783 Coenzyme A binding pocket [chemical binding]; other site 264730002784 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 264730002785 active site clefts [active] 264730002786 zinc binding site [ion binding]; other site 264730002787 dimer interface [polypeptide binding]; other site 264730002788 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730002789 HAMP domain; Region: HAMP; pfam00672 264730002790 dimerization interface [polypeptide binding]; other site 264730002791 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730002792 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730002793 dimer interface [polypeptide binding]; other site 264730002794 putative CheW interface [polypeptide binding]; other site 264730002795 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 264730002796 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264730002797 Zn2+ binding site [ion binding]; other site 264730002798 Mg2+ binding site [ion binding]; other site 264730002799 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 264730002800 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 264730002801 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 264730002802 PhnA protein; Region: PhnA; pfam03831 264730002803 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 264730002804 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730002805 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730002806 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730002807 putative arabinose transporter; Provisional; Region: PRK03545 264730002808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730002809 putative substrate translocation pore; other site 264730002810 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 264730002811 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 264730002812 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264730002813 metal binding site [ion binding]; metal-binding site 264730002814 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264730002815 putative active site [active] 264730002816 putative metal binding site [ion binding]; other site 264730002817 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730002818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730002819 dimerization interface [polypeptide binding]; other site 264730002820 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730002821 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730002822 dimer interface [polypeptide binding]; other site 264730002823 putative CheW interface [polypeptide binding]; other site 264730002824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730002825 Coenzyme A binding pocket [chemical binding]; other site 264730002826 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730002827 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730002828 metal binding site [ion binding]; metal-binding site 264730002829 active site 264730002830 I-site; other site 264730002831 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264730002832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730002833 putative active site [active] 264730002834 heme pocket [chemical binding]; other site 264730002835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730002836 putative active site [active] 264730002837 heme pocket [chemical binding]; other site 264730002838 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730002839 dimer interface [polypeptide binding]; other site 264730002840 putative CheW interface [polypeptide binding]; other site 264730002841 Bacterial SH3 domain; Region: SH3_3; pfam08239 264730002842 Isochorismatase family; Region: Isochorismatase; pfam00857 264730002843 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 264730002844 catalytic triad [active] 264730002845 dimer interface [polypeptide binding]; other site 264730002846 conserved cis-peptide bond; other site 264730002847 PhoD-like phosphatase; Region: PhoD; pfam09423 264730002848 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264730002849 putative active site [active] 264730002850 putative metal binding site [ion binding]; other site 264730002851 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264730002852 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264730002853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264730002854 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264730002855 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264730002856 Gram-negative bacterial tonB protein; Region: TonB; cl10048 264730002857 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264730002858 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730002859 N-terminal plug; other site 264730002860 ligand-binding site [chemical binding]; other site 264730002861 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264730002862 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 264730002863 PLD-like domain; Region: PLDc_2; pfam13091 264730002864 putative active site [active] 264730002865 putative catalytic site [active] 264730002866 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 264730002867 PLD-like domain; Region: PLDc_2; pfam13091 264730002868 putative active site [active] 264730002869 putative catalytic site [active] 264730002870 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730002871 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730002872 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730002873 putative acetyltransferase YhhY; Provisional; Region: PRK10140 264730002874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730002875 Coenzyme A binding pocket [chemical binding]; other site 264730002876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264730002877 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 264730002878 MltA specific insert domain; Region: MltA; smart00925 264730002879 3D domain; Region: 3D; pfam06725 264730002880 S-type Pyocin; Region: Pyocin_S; pfam06958 264730002881 RES domain; Region: RES; cl02411 264730002882 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 264730002883 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 264730002884 Response regulator receiver domain; Region: Response_reg; pfam00072 264730002885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730002886 active site 264730002887 phosphorylation site [posttranslational modification] 264730002888 intermolecular recognition site; other site 264730002889 dimerization interface [polypeptide binding]; other site 264730002890 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 264730002891 PAS fold; Region: PAS_4; pfam08448 264730002892 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 264730002893 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 264730002894 hinge; other site 264730002895 active site 264730002896 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 264730002897 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 264730002898 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 264730002899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730002900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730002901 DNA binding residues [nucleotide binding] 264730002902 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 264730002903 active site 264730002904 catalytic residues [active] 264730002905 DctM-like transporters; Region: DctM; pfam06808 264730002906 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 264730002907 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 264730002908 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 264730002909 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 264730002910 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 264730002911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730002912 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264730002913 extended (e) SDRs; Region: SDR_e; cd08946 264730002914 NAD(P) binding site [chemical binding]; other site 264730002915 active site 264730002916 active site 264730002917 substrate binding site [chemical binding]; other site 264730002918 outer membrane porin, OprD family; Region: OprD; pfam03573 264730002919 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264730002920 classical (c) SDRs; Region: SDR_c; cd05233 264730002921 NAD(P) binding site [chemical binding]; other site 264730002922 active site 264730002923 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730002924 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730002925 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730002926 dimerization interface [polypeptide binding]; other site 264730002927 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730002928 dimer interface [polypeptide binding]; other site 264730002929 putative CheW interface [polypeptide binding]; other site 264730002930 circadian clock protein KaiC; Reviewed; Region: PRK09302 264730002931 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264730002932 Walker A motif; other site 264730002933 ATP binding site [chemical binding]; other site 264730002934 Walker B motif; other site 264730002935 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264730002936 Walker A motif; other site 264730002937 ATP binding site [chemical binding]; other site 264730002938 Walker B motif; other site 264730002939 PAS fold; Region: PAS_4; pfam08448 264730002940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730002941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730002942 dimer interface [polypeptide binding]; other site 264730002943 phosphorylation site [posttranslational modification] 264730002944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730002945 ATP binding site [chemical binding]; other site 264730002946 Mg2+ binding site [ion binding]; other site 264730002947 G-X-G motif; other site 264730002948 Response regulator receiver domain; Region: Response_reg; pfam00072 264730002949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730002950 active site 264730002951 phosphorylation site [posttranslational modification] 264730002952 intermolecular recognition site; other site 264730002953 dimerization interface [polypeptide binding]; other site 264730002954 Transposase domain (DUF772); Region: DUF772; pfam05598 264730002955 Domain of unknown function (DUF927); Region: DUF927; cl12098 264730002956 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264730002957 HSP70 interaction site [polypeptide binding]; other site 264730002958 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730002959 HAMP domain; Region: HAMP; pfam00672 264730002960 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730002961 dimer interface [polypeptide binding]; other site 264730002962 putative CheW interface [polypeptide binding]; other site 264730002963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730002964 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 264730002965 putative ADP-binding pocket [chemical binding]; other site 264730002966 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 264730002967 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 264730002968 NADP-binding site; other site 264730002969 homotetramer interface [polypeptide binding]; other site 264730002970 substrate binding site [chemical binding]; other site 264730002971 homodimer interface [polypeptide binding]; other site 264730002972 active site 264730002973 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 264730002974 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 264730002975 NADP-binding site; other site 264730002976 homotetramer interface [polypeptide binding]; other site 264730002977 substrate binding site [chemical binding]; other site 264730002978 homodimer interface [polypeptide binding]; other site 264730002979 active site 264730002980 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 264730002981 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 264730002982 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 264730002983 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 264730002984 Walker A/P-loop; other site 264730002985 ATP binding site [chemical binding]; other site 264730002986 Q-loop/lid; other site 264730002987 ABC transporter signature motif; other site 264730002988 Walker B; other site 264730002989 D-loop; other site 264730002990 H-loop/switch region; other site 264730002991 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 264730002992 putative carbohydrate binding site [chemical binding]; other site 264730002993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264730002994 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264730002995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730002996 S-adenosylmethionine binding site [chemical binding]; other site 264730002997 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 264730002998 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730002999 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 264730003000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730003001 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 264730003002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730003003 NAD(P) binding site [chemical binding]; other site 264730003004 active site 264730003005 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 264730003006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730003007 NAD(P) binding site [chemical binding]; other site 264730003008 active site 264730003009 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 264730003010 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264730003011 Ligand binding site; other site 264730003012 Putative Catalytic site; other site 264730003013 DXD motif; other site 264730003014 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264730003015 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 264730003016 substrate binding site; other site 264730003017 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 264730003018 hypothetical protein; Provisional; Region: PRK07233 264730003019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264730003020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730003021 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 264730003022 DNA-binding interface [nucleotide binding]; DNA binding site 264730003023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264730003024 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 264730003025 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 264730003026 substrate binding site; other site 264730003027 tetramer interface; other site 264730003028 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 264730003029 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 264730003030 NADP binding site [chemical binding]; other site 264730003031 active site 264730003032 putative substrate binding site [chemical binding]; other site 264730003033 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 264730003034 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 264730003035 NAD binding site [chemical binding]; other site 264730003036 substrate binding site [chemical binding]; other site 264730003037 homodimer interface [polypeptide binding]; other site 264730003038 active site 264730003039 Methyltransferase domain; Region: Methyltransf_24; pfam13578 264730003040 Rhamnan synthesis protein F; Region: RgpF; pfam05045 264730003041 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 264730003042 putative ligand binding site [chemical binding]; other site 264730003043 putative catalytic site [active] 264730003044 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730003045 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264730003046 transcriptional activator RfaH; Region: RfaH; TIGR01955 264730003047 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 264730003048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730003049 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264730003050 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264730003051 Probable Catalytic site; other site 264730003052 metal-binding site 264730003053 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 264730003054 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730003055 active site 264730003056 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 264730003057 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 264730003058 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 264730003059 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 264730003060 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730003061 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 264730003062 Walker A/P-loop; other site 264730003063 ATP binding site [chemical binding]; other site 264730003064 Q-loop/lid; other site 264730003065 ABC transporter signature motif; other site 264730003066 Walker B; other site 264730003067 D-loop; other site 264730003068 H-loop/switch region; other site 264730003069 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 264730003070 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730003071 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730003072 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264730003073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730003074 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 264730003075 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 264730003076 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 264730003077 Substrate binding site; other site 264730003078 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 264730003079 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 264730003080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 264730003081 Integrase core domain; Region: rve; pfam00665 264730003082 transposase/IS protein; Provisional; Region: PRK09183 264730003083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730003084 Walker A motif; other site 264730003085 ATP binding site [chemical binding]; other site 264730003086 Walker B motif; other site 264730003087 arginine finger; other site 264730003088 GTP-binding protein YchF; Reviewed; Region: PRK09601 264730003089 YchF GTPase; Region: YchF; cd01900 264730003090 G1 box; other site 264730003091 GTP/Mg2+ binding site [chemical binding]; other site 264730003092 Switch I region; other site 264730003093 G2 box; other site 264730003094 Switch II region; other site 264730003095 G3 box; other site 264730003096 G4 box; other site 264730003097 G5 box; other site 264730003098 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 264730003099 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 264730003100 putative active site [active] 264730003101 catalytic residue [active] 264730003102 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 264730003103 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 264730003104 5S rRNA interface [nucleotide binding]; other site 264730003105 CTC domain interface [polypeptide binding]; other site 264730003106 L16 interface [polypeptide binding]; other site 264730003107 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 264730003108 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 264730003109 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264730003110 active site 264730003111 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 264730003112 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264730003113 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 264730003114 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 264730003115 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 264730003116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730003117 TPR motif; other site 264730003118 binding surface 264730003119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730003120 binding surface 264730003121 TPR motif; other site 264730003122 TPR repeat; Region: TPR_11; pfam13414 264730003123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730003124 binding surface 264730003125 TPR motif; other site 264730003126 TPR repeat; Region: TPR_11; pfam13414 264730003127 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 264730003128 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 264730003129 tRNA; other site 264730003130 putative tRNA binding site [nucleotide binding]; other site 264730003131 putative NADP binding site [chemical binding]; other site 264730003132 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 264730003133 peptide chain release factor 1; Validated; Region: prfA; PRK00591 264730003134 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264730003135 RF-1 domain; Region: RF-1; pfam00472 264730003136 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 264730003137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730003138 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 264730003139 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 264730003140 ATP binding site [chemical binding]; other site 264730003141 substrate interface [chemical binding]; other site 264730003142 glutamate racemase; Provisional; Region: PRK00865 264730003143 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 264730003144 Flagellin N-methylase; Region: FliB; pfam03692 264730003145 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 264730003146 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 264730003147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730003148 S-adenosylmethionine binding site [chemical binding]; other site 264730003149 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 264730003150 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 264730003151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264730003152 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264730003153 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 264730003154 classical (c) SDRs; Region: SDR_c; cd05233 264730003155 NAD(P) binding site [chemical binding]; other site 264730003156 active site 264730003157 SnoaL-like domain; Region: SnoaL_2; pfam12680 264730003158 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 264730003159 DNA photolyase; Region: DNA_photolyase; pfam00875 264730003160 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 264730003161 DNA binding residues [nucleotide binding] 264730003162 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 264730003163 B12 binding domain; Region: B12-binding_2; pfam02607 264730003164 Protein of unknown function (DUF523); Region: DUF523; pfam04463 264730003165 Uncharacterized conserved protein [Function unknown]; Region: COG3272 264730003166 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 264730003167 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 264730003168 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 264730003169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264730003170 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 264730003171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730003172 NAD(P) binding site [chemical binding]; other site 264730003173 active site 264730003174 ferrochelatase; Reviewed; Region: hemH; PRK00035 264730003175 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 264730003176 C-terminal domain interface [polypeptide binding]; other site 264730003177 active site 264730003178 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 264730003179 active site 264730003180 N-terminal domain interface [polypeptide binding]; other site 264730003181 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 264730003182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264730003183 active site 264730003184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264730003185 active site 264730003186 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 264730003187 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730003188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730003189 putative PBP binding loops; other site 264730003190 dimer interface [polypeptide binding]; other site 264730003191 ABC-ATPase subunit interface; other site 264730003192 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730003193 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730003194 substrate binding pocket [chemical binding]; other site 264730003195 membrane-bound complex binding site; other site 264730003196 hinge residues; other site 264730003197 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 264730003198 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 264730003199 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 264730003200 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 264730003201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730003202 AAA domain; Region: AAA_23; pfam13476 264730003203 Walker A/P-loop; other site 264730003204 ATP binding site [chemical binding]; other site 264730003205 AAA domain; Region: AAA_21; pfam13304 264730003206 TIGR02646 family protein; Region: TIGR02646 264730003207 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 264730003208 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264730003209 putative acyl-acceptor binding pocket; other site 264730003210 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 264730003211 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 264730003212 Uncharacterized conserved protein [Function unknown]; Region: COG2135 264730003213 Peptidase family M48; Region: Peptidase_M48; pfam01435 264730003214 Predicted membrane protein [Function unknown]; Region: COG2119 264730003215 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264730003216 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264730003217 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 264730003218 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 264730003219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730003220 S-adenosylmethionine binding site [chemical binding]; other site 264730003221 LysE type translocator; Region: LysE; cl00565 264730003222 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264730003223 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264730003224 acyl-activating enzyme (AAE) consensus motif; other site 264730003225 AMP binding site [chemical binding]; other site 264730003226 active site 264730003227 CoA binding site [chemical binding]; other site 264730003228 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 264730003229 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264730003230 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 264730003231 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264730003232 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264730003233 Zn2+ binding site [ion binding]; other site 264730003234 Mg2+ binding site [ion binding]; other site 264730003235 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 264730003236 pyrimidine utilization protein D; Region: RutD; TIGR03611 264730003237 TAP-like protein; Region: Abhydrolase_4; pfam08386 264730003238 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264730003239 homotrimer interaction site [polypeptide binding]; other site 264730003240 putative active site [active] 264730003241 Isochorismatase family; Region: Isochorismatase; pfam00857 264730003242 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 264730003243 catalytic triad [active] 264730003244 conserved cis-peptide bond; other site 264730003245 pyrimidine utilization protein A; Region: RutA; TIGR03612 264730003246 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264730003247 active site 264730003248 dimer interface [polypeptide binding]; other site 264730003249 non-prolyl cis peptide bond; other site 264730003250 insertion regions; other site 264730003251 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 264730003252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730003253 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 264730003254 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 264730003255 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 264730003256 putative ligand binding site [chemical binding]; other site 264730003257 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 264730003258 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264730003259 Walker A/P-loop; other site 264730003260 ATP binding site [chemical binding]; other site 264730003261 Q-loop/lid; other site 264730003262 ABC transporter signature motif; other site 264730003263 Walker B; other site 264730003264 D-loop; other site 264730003265 H-loop/switch region; other site 264730003266 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264730003267 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730003268 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264730003269 TM-ABC transporter signature motif; other site 264730003270 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730003271 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264730003272 TM-ABC transporter signature motif; other site 264730003273 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264730003274 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730003275 ligand binding site [chemical binding]; other site 264730003276 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264730003277 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 264730003278 putative acyl-acceptor binding pocket; other site 264730003279 phosphate acetyltransferase; Reviewed; Region: PRK05632 264730003280 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264730003281 DRTGG domain; Region: DRTGG; pfam07085 264730003282 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 264730003283 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 264730003284 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 264730003285 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264730003286 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264730003287 catalytic residues [active] 264730003288 dimer interface [polypeptide binding]; other site 264730003289 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 264730003290 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 264730003291 putative active site [active] 264730003292 putative FMN binding site [chemical binding]; other site 264730003293 putative substrate binding site [chemical binding]; other site 264730003294 putative catalytic residue [active] 264730003295 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 264730003296 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 264730003297 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730003298 Flagellar protein FlhE; Region: FlhE; pfam06366 264730003299 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730003300 MULE transposase domain; Region: MULE; pfam10551 264730003301 putative sulfate transport protein CysZ; Validated; Region: PRK04949 264730003302 thioredoxin reductase; Provisional; Region: PRK10262 264730003303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730003304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264730003305 HopJ type III effector protein; Region: HopJ; pfam08888 264730003306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 264730003307 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 264730003308 homooctamer interface [polypeptide binding]; other site 264730003309 active site 264730003310 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 264730003311 homodecamer interface [polypeptide binding]; other site 264730003312 GTP cyclohydrolase I; Provisional; Region: PLN03044 264730003313 active site 264730003314 putative catalytic site residues [active] 264730003315 zinc binding site [ion binding]; other site 264730003316 GTP-CH-I/GFRP interaction surface; other site 264730003317 dihydromonapterin reductase; Provisional; Region: PRK06483 264730003318 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 264730003319 NADP binding site [chemical binding]; other site 264730003320 substrate binding pocket [chemical binding]; other site 264730003321 active site 264730003322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 264730003323 flavodoxin; Provisional; Region: PRK05723 264730003324 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 264730003325 homodimer interface [polypeptide binding]; other site 264730003326 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264730003327 NAD binding site [chemical binding]; other site 264730003328 active site 264730003329 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 264730003330 Tetratricopeptide repeat; Region: TPR_9; pfam13371 264730003331 hypothetical protein; Provisional; Region: PRK09936 264730003332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730003333 TPR motif; other site 264730003334 binding surface 264730003335 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 264730003336 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 264730003337 active site 264730003338 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 264730003339 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 264730003340 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 264730003341 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 264730003342 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 264730003343 active site 264730003344 homodimer interface [polypeptide binding]; other site 264730003345 YebG protein; Region: YebG; pfam07130 264730003346 Predicted membrane protein [Function unknown]; Region: COG3223 264730003347 Sel1 repeat; Region: Sel1; cl02723 264730003348 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264730003349 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 264730003350 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 264730003351 30S subunit binding site; other site 264730003352 Secretin and TonB N terminus short domain; Region: STN; smart00965 264730003353 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 264730003354 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730003355 N-terminal plug; other site 264730003356 ligand-binding site [chemical binding]; other site 264730003357 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 264730003358 FecR protein; Region: FecR; pfam04773 264730003359 RNA polymerase sigma factor; Provisional; Region: PRK12528 264730003360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730003361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730003362 DNA binding residues [nucleotide binding] 264730003363 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 264730003364 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264730003365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730003366 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264730003367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730003368 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264730003369 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 264730003370 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 264730003371 dimerization interface [polypeptide binding]; other site 264730003372 ligand binding site [chemical binding]; other site 264730003373 NADP binding site [chemical binding]; other site 264730003374 catalytic site [active] 264730003375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730003376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730003377 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264730003378 putative effector binding pocket; other site 264730003379 dimerization interface [polypeptide binding]; other site 264730003380 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264730003381 Fusaric acid resistance protein family; Region: FUSC; pfam04632 264730003382 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264730003383 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 264730003384 HlyD family secretion protein; Region: HlyD; pfam00529 264730003385 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730003386 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730003387 short chain dehydrogenase; Provisional; Region: PRK05693 264730003388 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 264730003389 NADP binding site [chemical binding]; other site 264730003390 active site 264730003391 steroid binding site; other site 264730003392 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 264730003393 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 264730003394 Substrate binding site; other site 264730003395 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 264730003396 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 264730003397 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 264730003398 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 264730003399 active site 264730003400 Right handed beta helix region; Region: Beta_helix; pfam13229 264730003401 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 264730003402 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264730003403 PilZ domain; Region: PilZ; pfam07238 264730003404 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730003405 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264730003406 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 264730003407 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 264730003408 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 264730003409 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 264730003410 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 264730003411 hypothetical protein; Validated; Region: PRK02101 264730003412 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 264730003413 NodB motif; other site 264730003414 active site 264730003415 catalytic site [active] 264730003416 metal binding site [ion binding]; metal-binding site 264730003417 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 264730003418 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 264730003419 putative active site [active] 264730003420 PhoH-like protein; Region: PhoH; pfam02562 264730003421 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 264730003422 trimer interface [polypeptide binding]; other site 264730003423 dimer interface [polypeptide binding]; other site 264730003424 putative active site [active] 264730003425 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 264730003426 MoaE interaction surface [polypeptide binding]; other site 264730003427 MoeB interaction surface [polypeptide binding]; other site 264730003428 thiocarboxylated glycine; other site 264730003429 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 264730003430 MoaE homodimer interface [polypeptide binding]; other site 264730003431 MoaD interaction [polypeptide binding]; other site 264730003432 active site residues [active] 264730003433 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 264730003434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 264730003435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 264730003436 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 264730003437 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264730003438 ATP binding site [chemical binding]; other site 264730003439 Mg++ binding site [ion binding]; other site 264730003440 motif III; other site 264730003441 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730003442 nucleotide binding region [chemical binding]; other site 264730003443 ATP-binding site [chemical binding]; other site 264730003444 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 264730003445 putative hydrolase; Provisional; Region: PRK11460 264730003446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730003447 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 264730003448 substrate binding pocket [chemical binding]; other site 264730003449 membrane-bound complex binding site; other site 264730003450 hinge residues; other site 264730003451 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 264730003452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730003453 conserved gate region; other site 264730003454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730003455 dimer interface [polypeptide binding]; other site 264730003456 putative PBP binding loops; other site 264730003457 ABC-ATPase subunit interface; other site 264730003458 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730003459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730003460 dimer interface [polypeptide binding]; other site 264730003461 conserved gate region; other site 264730003462 putative PBP binding loops; other site 264730003463 ABC-ATPase subunit interface; other site 264730003464 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264730003465 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264730003466 Walker A/P-loop; other site 264730003467 ATP binding site [chemical binding]; other site 264730003468 Q-loop/lid; other site 264730003469 ABC transporter signature motif; other site 264730003470 Walker B; other site 264730003471 D-loop; other site 264730003472 H-loop/switch region; other site 264730003473 cyanate transporter; Region: CynX; TIGR00896 264730003474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730003475 putative substrate translocation pore; other site 264730003476 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 264730003477 NmrA-like family; Region: NmrA; pfam05368 264730003478 NAD(P) binding site [chemical binding]; other site 264730003479 active site lysine 264730003480 Predicted transcriptional regulators [Transcription]; Region: COG1733 264730003481 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 264730003482 SnoaL-like domain; Region: SnoaL_3; pfam13474 264730003483 SnoaL-like domain; Region: SnoaL_2; pfam12680 264730003484 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 264730003485 GIY-YIG motif/motif A; other site 264730003486 putative active site [active] 264730003487 putative metal binding site [ion binding]; other site 264730003488 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264730003489 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 264730003490 C-terminal domain interface [polypeptide binding]; other site 264730003491 GSH binding site (G-site) [chemical binding]; other site 264730003492 dimer interface [polypeptide binding]; other site 264730003493 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 264730003494 N-terminal domain interface [polypeptide binding]; other site 264730003495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 264730003496 Integrase core domain; Region: rve; pfam00665 264730003497 transposase/IS protein; Provisional; Region: PRK09183 264730003498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730003499 Walker A motif; other site 264730003500 ATP binding site [chemical binding]; other site 264730003501 Walker B motif; other site 264730003502 arginine finger; other site 264730003503 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 264730003504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730003505 Walker A/P-loop; other site 264730003506 ATP binding site [chemical binding]; other site 264730003507 Nucleoid-associated protein [General function prediction only]; Region: COG3081 264730003508 nucleoid-associated protein NdpA; Validated; Region: PRK00378 264730003509 transcriptional regulator BetI; Validated; Region: PRK00767 264730003510 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730003511 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 264730003512 active site 264730003513 DNA binding site [nucleotide binding] 264730003514 Int/Topo IB signature motif; other site 264730003515 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 264730003516 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264730003517 IHF dimer interface [polypeptide binding]; other site 264730003518 IHF - DNA interface [nucleotide binding]; other site 264730003519 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 264730003520 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 264730003521 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 264730003522 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264730003523 HIGH motif; other site 264730003524 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264730003525 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264730003526 active site 264730003527 KMSKS motif; other site 264730003528 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 264730003529 tRNA binding surface [nucleotide binding]; other site 264730003530 anticodon binding site; other site 264730003531 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 264730003532 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730003533 F-box domain; Region: F-box; pfam00646 264730003534 DNA polymerase III subunit chi; Validated; Region: PRK05728 264730003535 multifunctional aminopeptidase A; Provisional; Region: PRK00913 264730003536 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 264730003537 interface (dimer of trimers) [polypeptide binding]; other site 264730003538 Substrate-binding/catalytic site; other site 264730003539 Zn-binding sites [ion binding]; other site 264730003540 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 264730003541 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264730003542 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 264730003543 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264730003544 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264730003545 DNA-binding site [nucleotide binding]; DNA binding site 264730003546 RNA-binding motif; other site 264730003547 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 264730003548 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264730003549 glycine dehydrogenase; Provisional; Region: PRK05367 264730003550 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264730003551 tetramer interface [polypeptide binding]; other site 264730003552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730003553 catalytic residue [active] 264730003554 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264730003555 tetramer interface [polypeptide binding]; other site 264730003556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730003557 catalytic residue [active] 264730003558 glycine cleavage system protein H; Provisional; Region: PRK13380 264730003559 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264730003560 lipoyl attachment site [posttranslational modification]; other site 264730003561 Outer membrane efflux protein; Region: OEP; pfam02321 264730003562 response regulator PleD; Reviewed; Region: pleD; PRK09581 264730003563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730003564 active site 264730003565 phosphorylation site [posttranslational modification] 264730003566 intermolecular recognition site; other site 264730003567 dimerization interface [polypeptide binding]; other site 264730003568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730003569 putative active site [active] 264730003570 heme pocket [chemical binding]; other site 264730003571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730003572 metal binding site [ion binding]; metal-binding site 264730003573 active site 264730003574 I-site; other site 264730003575 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730003576 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730003577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730003578 active site 264730003579 phosphorylation site [posttranslational modification] 264730003580 intermolecular recognition site; other site 264730003581 dimerization interface [polypeptide binding]; other site 264730003582 PAS domain S-box; Region: sensory_box; TIGR00229 264730003583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730003584 putative active site [active] 264730003585 heme pocket [chemical binding]; other site 264730003586 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730003587 PAS domain; Region: PAS_9; pfam13426 264730003588 putative active site [active] 264730003589 heme pocket [chemical binding]; other site 264730003590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730003591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730003592 dimer interface [polypeptide binding]; other site 264730003593 phosphorylation site [posttranslational modification] 264730003594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730003595 ATP binding site [chemical binding]; other site 264730003596 Mg2+ binding site [ion binding]; other site 264730003597 G-X-G motif; other site 264730003598 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 264730003599 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 264730003600 putative aromatic amino acid binding site; other site 264730003601 PAS domain; Region: PAS; smart00091 264730003602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730003603 Walker A motif; other site 264730003604 ATP binding site [chemical binding]; other site 264730003605 Walker B motif; other site 264730003606 arginine finger; other site 264730003607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 264730003608 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 264730003609 heme binding pocket [chemical binding]; other site 264730003610 heme ligand [chemical binding]; other site 264730003611 Secretin and TonB N terminus short domain; Region: STN; smart00965 264730003612 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 264730003613 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730003614 N-terminal plug; other site 264730003615 ligand-binding site [chemical binding]; other site 264730003616 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 264730003617 FecR protein; Region: FecR; pfam04773 264730003618 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264730003619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730003620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730003621 DNA binding residues [nucleotide binding] 264730003622 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 264730003623 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 264730003624 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 264730003625 phosphogluconate dehydratase; Validated; Region: PRK09054 264730003626 6-phosphogluconate dehydratase; Region: edd; TIGR01196 264730003627 glucokinase, proteobacterial type; Region: glk; TIGR00749 264730003628 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264730003629 nucleotide binding site [chemical binding]; other site 264730003630 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264730003631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730003632 active site 264730003633 phosphorylation site [posttranslational modification] 264730003634 intermolecular recognition site; other site 264730003635 dimerization interface [polypeptide binding]; other site 264730003636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730003637 DNA binding site [nucleotide binding] 264730003638 HAMP domain; Region: HAMP; pfam00672 264730003639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730003640 ATP binding site [chemical binding]; other site 264730003641 Mg2+ binding site [ion binding]; other site 264730003642 G-X-G motif; other site 264730003643 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 264730003644 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 264730003645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730003646 dimer interface [polypeptide binding]; other site 264730003647 conserved gate region; other site 264730003648 putative PBP binding loops; other site 264730003649 ABC-ATPase subunit interface; other site 264730003650 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264730003651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730003652 dimer interface [polypeptide binding]; other site 264730003653 conserved gate region; other site 264730003654 putative PBP binding loops; other site 264730003655 ABC-ATPase subunit interface; other site 264730003656 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 264730003657 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 264730003658 Walker A/P-loop; other site 264730003659 ATP binding site [chemical binding]; other site 264730003660 Q-loop/lid; other site 264730003661 ABC transporter signature motif; other site 264730003662 Walker B; other site 264730003663 D-loop; other site 264730003664 H-loop/switch region; other site 264730003665 TOBE domain; Region: TOBE_2; pfam08402 264730003666 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 264730003667 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 264730003668 active site 264730003669 phosphate binding residues; other site 264730003670 catalytic residues [active] 264730003671 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 264730003672 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264730003673 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264730003674 putative active site [active] 264730003675 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 264730003676 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 264730003677 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 264730003678 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 264730003679 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 264730003680 putative active site [active] 264730003681 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 264730003682 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 264730003683 active site 264730003684 intersubunit interface [polypeptide binding]; other site 264730003685 catalytic residue [active] 264730003686 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 264730003687 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 264730003688 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730003689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730003690 metal binding site [ion binding]; metal-binding site 264730003691 active site 264730003692 I-site; other site 264730003693 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264730003694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264730003695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730003696 dimer interface [polypeptide binding]; other site 264730003697 phosphorylation site [posttranslational modification] 264730003698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730003699 ATP binding site [chemical binding]; other site 264730003700 Mg2+ binding site [ion binding]; other site 264730003701 G-X-G motif; other site 264730003702 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 264730003703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730003704 active site 264730003705 phosphorylation site [posttranslational modification] 264730003706 intermolecular recognition site; other site 264730003707 dimerization interface [polypeptide binding]; other site 264730003708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730003709 DNA binding site [nucleotide binding] 264730003710 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 264730003711 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264730003712 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730003713 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730003714 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 264730003715 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 264730003716 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 264730003717 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 264730003718 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 264730003719 PapC N-terminal domain; Region: PapC_N; pfam13954 264730003720 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 264730003721 PapC C-terminal domain; Region: PapC_C; pfam13953 264730003722 Fimbrial protein; Region: Fimbrial; pfam00419 264730003723 Flagellin N-methylase; Region: FliB; pfam03692 264730003724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 264730003725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730003726 Coenzyme A binding pocket [chemical binding]; other site 264730003727 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 264730003728 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730003729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730003730 active site 264730003731 phosphorylation site [posttranslational modification] 264730003732 intermolecular recognition site; other site 264730003733 dimerization interface [polypeptide binding]; other site 264730003734 disulfide bond formation protein B; Provisional; Region: PRK02110 264730003735 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 264730003736 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 264730003737 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 264730003738 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264730003739 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 264730003740 D-pathway; other site 264730003741 Putative ubiquinol binding site [chemical binding]; other site 264730003742 Low-spin heme (heme b) binding site [chemical binding]; other site 264730003743 Putative water exit pathway; other site 264730003744 Binuclear center (heme o3/CuB) [ion binding]; other site 264730003745 K-pathway; other site 264730003746 Putative proton exit pathway; other site 264730003747 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 264730003748 Subunit I/III interface [polypeptide binding]; other site 264730003749 Subunit III/IV interface [polypeptide binding]; other site 264730003750 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 264730003751 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 264730003752 UbiA prenyltransferase family; Region: UbiA; pfam01040 264730003753 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264730003754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264730003755 active site 264730003756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730003757 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 264730003758 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 264730003759 homodimer interface [polypeptide binding]; other site 264730003760 substrate-cofactor binding pocket; other site 264730003761 catalytic residue [active] 264730003762 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730003763 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730003764 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730003765 dimer interface [polypeptide binding]; other site 264730003766 putative CheW interface [polypeptide binding]; other site 264730003767 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730003768 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730003769 substrate binding pocket [chemical binding]; other site 264730003770 membrane-bound complex binding site; other site 264730003771 hinge residues; other site 264730003772 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264730003773 dimerization interface [polypeptide binding]; other site 264730003774 putative DNA binding site [nucleotide binding]; other site 264730003775 putative Zn2+ binding site [ion binding]; other site 264730003776 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264730003777 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 264730003778 putative NAD(P) binding site [chemical binding]; other site 264730003779 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 264730003780 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 264730003781 E-class dimer interface [polypeptide binding]; other site 264730003782 P-class dimer interface [polypeptide binding]; other site 264730003783 active site 264730003784 Cu2+ binding site [ion binding]; other site 264730003785 Zn2+ binding site [ion binding]; other site 264730003786 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 264730003787 hypothetical protein; Provisional; Region: PRK06156 264730003788 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 264730003789 active site 264730003790 metal binding site [ion binding]; metal-binding site 264730003791 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730003792 PAS domain; Region: PAS_9; pfam13426 264730003793 putative active site [active] 264730003794 heme pocket [chemical binding]; other site 264730003795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730003796 PAS domain; Region: PAS_9; pfam13426 264730003797 putative active site [active] 264730003798 heme pocket [chemical binding]; other site 264730003799 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730003800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730003801 metal binding site [ion binding]; metal-binding site 264730003802 active site 264730003803 I-site; other site 264730003804 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730003805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730003806 DNA-binding site [nucleotide binding]; DNA binding site 264730003807 FCD domain; Region: FCD; pfam07729 264730003808 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 264730003809 Isochorismatase family; Region: Isochorismatase; pfam00857 264730003810 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 264730003811 catalytic triad [active] 264730003812 conserved cis-peptide bond; other site 264730003813 Isochorismatase family; Region: Isochorismatase; pfam00857 264730003814 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 264730003815 catalytic triad [active] 264730003816 conserved cis-peptide bond; other site 264730003817 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730003818 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264730003819 TM-ABC transporter signature motif; other site 264730003820 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730003821 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264730003822 TM-ABC transporter signature motif; other site 264730003823 allophanate hydrolase; Provisional; Region: PRK08186 264730003824 Amidase; Region: Amidase; cl11426 264730003825 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 264730003826 dimer interface [polypeptide binding]; other site 264730003827 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264730003828 ligand binding site [chemical binding]; other site 264730003829 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264730003830 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730003831 putative DNA binding site [nucleotide binding]; other site 264730003832 putative Zn2+ binding site [ion binding]; other site 264730003833 AsnC family; Region: AsnC_trans_reg; pfam01037 264730003834 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264730003835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730003836 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 264730003837 putative substrate translocation pore; other site 264730003838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730003839 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 264730003840 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 264730003841 heme-binding site [chemical binding]; other site 264730003842 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 264730003843 FAD binding pocket [chemical binding]; other site 264730003844 FAD binding motif [chemical binding]; other site 264730003845 phosphate binding motif [ion binding]; other site 264730003846 beta-alpha-beta structure motif; other site 264730003847 NAD binding pocket [chemical binding]; other site 264730003848 Heme binding pocket [chemical binding]; other site 264730003849 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264730003850 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264730003851 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 264730003852 putative C-terminal domain interface [polypeptide binding]; other site 264730003853 putative GSH binding site (G-site) [chemical binding]; other site 264730003854 putative dimer interface [polypeptide binding]; other site 264730003855 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 264730003856 putative N-terminal domain interface [polypeptide binding]; other site 264730003857 putative dimer interface [polypeptide binding]; other site 264730003858 putative substrate binding pocket (H-site) [chemical binding]; other site 264730003859 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 264730003860 OPT oligopeptide transporter protein; Region: OPT; pfam03169 264730003861 AAA domain; Region: AAA_33; pfam13671 264730003862 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 264730003863 active site 264730003864 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 264730003865 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264730003866 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264730003867 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 264730003868 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264730003869 PYR/PP interface [polypeptide binding]; other site 264730003870 dimer interface [polypeptide binding]; other site 264730003871 TPP binding site [chemical binding]; other site 264730003872 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264730003873 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 264730003874 TPP-binding site [chemical binding]; other site 264730003875 dimer interface [polypeptide binding]; other site 264730003876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730003877 D-galactonate transporter; Region: 2A0114; TIGR00893 264730003878 putative substrate translocation pore; other site 264730003879 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264730003880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730003881 NAD(P) binding site [chemical binding]; other site 264730003882 active site 264730003883 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264730003884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730003885 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264730003886 dimerization interface [polypeptide binding]; other site 264730003887 substrate binding pocket [chemical binding]; other site 264730003888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730003889 GAF domain; Region: GAF; cl17456 264730003890 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 264730003891 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 264730003892 GAF domain; Region: GAF; cl17456 264730003893 PAS fold; Region: PAS_3; pfam08447 264730003894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730003895 dimer interface [polypeptide binding]; other site 264730003896 phosphorylation site [posttranslational modification] 264730003897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730003898 ATP binding site [chemical binding]; other site 264730003899 Mg2+ binding site [ion binding]; other site 264730003900 G-X-G motif; other site 264730003901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730003902 Response regulator receiver domain; Region: Response_reg; pfam00072 264730003903 active site 264730003904 phosphorylation site [posttranslational modification] 264730003905 intermolecular recognition site; other site 264730003906 dimerization interface [polypeptide binding]; other site 264730003907 Pectate lyase; Region: Pectate_lyase; pfam03211 264730003908 Tir chaperone protein (CesT) family; Region: CesT; cl08444 264730003909 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 264730003910 Pathogenicity factor; Region: AvrE; pfam11725 264730003911 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 264730003912 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264730003913 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264730003914 catalytic residue [active] 264730003915 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264730003916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730003917 Walker A motif; other site 264730003918 ATP binding site [chemical binding]; other site 264730003919 Walker B motif; other site 264730003920 arginine finger; other site 264730003921 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730003922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730003923 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264730003924 Walker A motif; other site 264730003925 ATP binding site [chemical binding]; other site 264730003926 Walker B motif; other site 264730003927 arginine finger; other site 264730003928 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730003929 HrpA pilus formation protein; Region: HrpA_pilin; pfam09589 264730003930 HrpZ; Region: Hairpins; pfam04877 264730003931 Type III secretion needle MxiH like; Region: MxiH; pfam09392 264730003932 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 264730003933 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 264730003934 HrpF protein; Region: HrpF; pfam06266 264730003935 outer membrane secretin SsaC; Provisional; Region: PRK15346 264730003936 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264730003937 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264730003938 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264730003939 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 264730003940 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 264730003941 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 264730003942 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 264730003943 type III secretion system protein YscR; Provisional; Region: PRK12797 264730003944 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 264730003945 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 264730003946 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 264730003947 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 264730003948 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264730003949 Walker A motif; other site 264730003950 ATP binding site [chemical binding]; other site 264730003951 Walker B motif; other site 264730003952 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 264730003953 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 264730003954 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 264730003955 FHIPEP family; Region: FHIPEP; pfam00771 264730003956 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 264730003957 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 264730003958 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 264730003959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730003960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730003961 DNA binding residues [nucleotide binding] 264730003962 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 264730003963 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 264730003964 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 264730003965 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 264730003966 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 264730003967 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 264730003968 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 264730003969 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 264730003970 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 264730003971 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 264730003972 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 264730003973 Protein export membrane protein; Region: SecD_SecF; pfam02355 264730003974 hypothetical protein; Provisional; Region: PRK11280 264730003975 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 264730003976 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 264730003977 active site 264730003978 dimerization interface [polypeptide binding]; other site 264730003979 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 264730003980 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264730003981 serine O-acetyltransferase; Region: cysE; TIGR01172 264730003982 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 264730003983 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264730003984 trimer interface [polypeptide binding]; other site 264730003985 active site 264730003986 substrate binding site [chemical binding]; other site 264730003987 CoA binding site [chemical binding]; other site 264730003988 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 264730003989 Rrf2 family protein; Region: rrf2_super; TIGR00738 264730003990 cysteine desulfurase; Provisional; Region: PRK14012 264730003991 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 264730003992 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730003993 catalytic residue [active] 264730003994 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 264730003995 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 264730003996 trimerization site [polypeptide binding]; other site 264730003997 active site 264730003998 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 264730003999 co-chaperone HscB; Provisional; Region: hscB; PRK00294 264730004000 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264730004001 HSP70 interaction site [polypeptide binding]; other site 264730004002 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 264730004003 chaperone protein HscA; Provisional; Region: hscA; PRK05183 264730004004 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 264730004005 nucleotide binding site [chemical binding]; other site 264730004006 putative NEF/HSP70 interaction site [polypeptide binding]; other site 264730004007 SBD interface [polypeptide binding]; other site 264730004008 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 264730004009 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264730004010 catalytic loop [active] 264730004011 iron binding site [ion binding]; other site 264730004012 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 264730004013 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 264730004014 active site 264730004015 multimer interface [polypeptide binding]; other site 264730004016 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 264730004017 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730004018 FeS/SAM binding site; other site 264730004019 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 264730004020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730004021 binding surface 264730004022 TPR motif; other site 264730004023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730004024 binding surface 264730004025 TPR motif; other site 264730004026 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 264730004027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730004028 non-specific DNA binding site [nucleotide binding]; other site 264730004029 salt bridge; other site 264730004030 sequence-specific DNA binding site [nucleotide binding]; other site 264730004031 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 264730004032 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 264730004033 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 264730004034 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 264730004035 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 264730004036 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 264730004037 dimer interface [polypeptide binding]; other site 264730004038 motif 1; other site 264730004039 active site 264730004040 motif 2; other site 264730004041 motif 3; other site 264730004042 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 264730004043 anticodon binding site; other site 264730004044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 264730004045 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 264730004046 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 264730004047 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 264730004048 Trp docking motif [polypeptide binding]; other site 264730004049 GTP-binding protein Der; Reviewed; Region: PRK00093 264730004050 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 264730004051 G1 box; other site 264730004052 GTP/Mg2+ binding site [chemical binding]; other site 264730004053 Switch I region; other site 264730004054 G2 box; other site 264730004055 Switch II region; other site 264730004056 G3 box; other site 264730004057 G4 box; other site 264730004058 G5 box; other site 264730004059 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 264730004060 G1 box; other site 264730004061 GTP/Mg2+ binding site [chemical binding]; other site 264730004062 Switch I region; other site 264730004063 G2 box; other site 264730004064 G3 box; other site 264730004065 Switch II region; other site 264730004066 G4 box; other site 264730004067 G5 box; other site 264730004068 methionine aminotransferase; Validated; Region: PRK09082 264730004069 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730004070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730004071 homodimer interface [polypeptide binding]; other site 264730004072 catalytic residue [active] 264730004073 C-N hydrolase family amidase; Provisional; Region: PRK10438 264730004074 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 264730004075 putative active site [active] 264730004076 catalytic triad [active] 264730004077 dimer interface [polypeptide binding]; other site 264730004078 multimer interface [polypeptide binding]; other site 264730004079 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 264730004080 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264730004081 tetramer interface [polypeptide binding]; other site 264730004082 active site 264730004083 Mg2+/Mn2+ binding site [ion binding]; other site 264730004084 2-isopropylmalate synthase; Validated; Region: PRK03739 264730004085 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 264730004086 active site 264730004087 catalytic residues [active] 264730004088 metal binding site [ion binding]; metal-binding site 264730004089 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 264730004090 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264730004091 Peptidase family M23; Region: Peptidase_M23; pfam01551 264730004092 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 264730004093 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 264730004094 generic binding surface II; other site 264730004095 generic binding surface I; other site 264730004096 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 264730004097 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264730004098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 264730004099 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 264730004100 active site 264730004101 GMP synthase; Reviewed; Region: guaA; PRK00074 264730004102 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 264730004103 AMP/PPi binding site [chemical binding]; other site 264730004104 candidate oxyanion hole; other site 264730004105 catalytic triad [active] 264730004106 potential glutamine specificity residues [chemical binding]; other site 264730004107 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 264730004108 ATP Binding subdomain [chemical binding]; other site 264730004109 Ligand Binding sites [chemical binding]; other site 264730004110 Dimerization subdomain; other site 264730004111 Part of AAA domain; Region: AAA_19; pfam13245 264730004112 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 264730004113 AAA domain; Region: AAA_12; pfam13087 264730004114 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 264730004115 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730004116 MULE transposase domain; Region: MULE; pfam10551 264730004117 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 264730004118 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 264730004119 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 264730004120 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264730004121 nucleoside/Zn binding site; other site 264730004122 dimer interface [polypeptide binding]; other site 264730004123 catalytic motif [active] 264730004124 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 264730004125 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730004126 substrate binding pocket [chemical binding]; other site 264730004127 membrane-bound complex binding site; other site 264730004128 hinge residues; other site 264730004129 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264730004130 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264730004131 catalytic residue [active] 264730004132 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 264730004133 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 264730004134 dimerization interface [polypeptide binding]; other site 264730004135 ATP binding site [chemical binding]; other site 264730004136 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 264730004137 dimerization interface [polypeptide binding]; other site 264730004138 ATP binding site [chemical binding]; other site 264730004139 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 264730004140 putative active site [active] 264730004141 catalytic triad [active] 264730004142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 264730004143 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264730004144 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 264730004145 nudix motif; other site 264730004146 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 264730004147 putative active site [active] 264730004148 putative CoA binding site [chemical binding]; other site 264730004149 nudix motif; other site 264730004150 metal binding site [ion binding]; metal-binding site 264730004151 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264730004152 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 264730004153 trimer interface [polypeptide binding]; other site 264730004154 putative metal binding site [ion binding]; other site 264730004155 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 264730004156 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 264730004157 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 264730004158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730004159 ATP-grasp domain; Region: ATP-grasp; pfam02222 264730004160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730004161 metabolite-proton symporter; Region: 2A0106; TIGR00883 264730004162 putative substrate translocation pore; other site 264730004163 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 264730004164 Domain of unknown function DUF21; Region: DUF21; pfam01595 264730004165 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264730004166 Transporter associated domain; Region: CorC_HlyC; smart01091 264730004167 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 264730004168 signal recognition particle protein; Provisional; Region: PRK10867 264730004169 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 264730004170 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264730004171 P loop; other site 264730004172 GTP binding site [chemical binding]; other site 264730004173 Signal peptide binding domain; Region: SRP_SPB; pfam02978 264730004174 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 264730004175 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 264730004176 RimM N-terminal domain; Region: RimM; pfam01782 264730004177 PRC-barrel domain; Region: PRC; pfam05239 264730004178 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 264730004179 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 264730004180 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 264730004181 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 264730004182 active site 264730004183 Int/Topo IB signature motif; other site 264730004184 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 264730004185 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 264730004186 dimerization domain [polypeptide binding]; other site 264730004187 dimer interface [polypeptide binding]; other site 264730004188 catalytic residues [active] 264730004189 homoserine dehydrogenase; Provisional; Region: PRK06349 264730004190 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 264730004191 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 264730004192 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 264730004193 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 264730004194 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 264730004195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730004196 catalytic residue [active] 264730004197 Response regulator receiver domain; Region: Response_reg; pfam00072 264730004198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730004199 active site 264730004200 phosphorylation site [posttranslational modification] 264730004201 intermolecular recognition site; other site 264730004202 dimerization interface [polypeptide binding]; other site 264730004203 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730004204 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730004205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730004206 active site 264730004207 phosphorylation site [posttranslational modification] 264730004208 intermolecular recognition site; other site 264730004209 dimerization interface [polypeptide binding]; other site 264730004210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730004211 DNA binding residues [nucleotide binding] 264730004212 dimerization interface [polypeptide binding]; other site 264730004213 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730004214 MULE transposase domain; Region: MULE; pfam10551 264730004215 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 264730004216 conserved hypothetical protein; Region: TIGR02285 264730004217 YaeQ protein; Region: YaeQ; pfam07152 264730004218 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 264730004219 DHH family; Region: DHH; pfam01368 264730004220 DHHA1 domain; Region: DHHA1; pfam02272 264730004221 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 264730004222 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 264730004223 active site 264730004224 FMN binding site [chemical binding]; other site 264730004225 substrate binding site [chemical binding]; other site 264730004226 homotetramer interface [polypeptide binding]; other site 264730004227 catalytic residue [active] 264730004228 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264730004229 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264730004230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730004231 putative active site [active] 264730004232 heme pocket [chemical binding]; other site 264730004233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730004234 dimer interface [polypeptide binding]; other site 264730004235 phosphorylation site [posttranslational modification] 264730004236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730004237 ATP binding site [chemical binding]; other site 264730004238 Mg2+ binding site [ion binding]; other site 264730004239 G-X-G motif; other site 264730004240 Response regulator receiver domain; Region: Response_reg; pfam00072 264730004241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730004242 active site 264730004243 phosphorylation site [posttranslational modification] 264730004244 intermolecular recognition site; other site 264730004245 dimerization interface [polypeptide binding]; other site 264730004246 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730004247 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730004248 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730004249 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730004250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730004251 active site 264730004252 phosphorylation site [posttranslational modification] 264730004253 intermolecular recognition site; other site 264730004254 dimerization interface [polypeptide binding]; other site 264730004255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730004256 DNA binding residues [nucleotide binding] 264730004257 dimerization interface [polypeptide binding]; other site 264730004258 endonuclease III; Provisional; Region: PRK10702 264730004259 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264730004260 minor groove reading motif; other site 264730004261 helix-hairpin-helix signature motif; other site 264730004262 substrate binding pocket [chemical binding]; other site 264730004263 active site 264730004264 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 264730004265 ferredoxin; Provisional; Region: PRK08764 264730004266 Putative Fe-S cluster; Region: FeS; pfam04060 264730004267 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264730004268 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 264730004269 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 264730004270 active site 264730004271 HIGH motif; other site 264730004272 KMSKS motif; other site 264730004273 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 264730004274 tRNA binding surface [nucleotide binding]; other site 264730004275 anticodon binding site; other site 264730004276 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 264730004277 dimer interface [polypeptide binding]; other site 264730004278 putative tRNA-binding site [nucleotide binding]; other site 264730004279 antiporter inner membrane protein; Provisional; Region: PRK11670 264730004280 Domain of unknown function DUF59; Region: DUF59; pfam01883 264730004281 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 264730004282 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264730004283 DNA-binding site [nucleotide binding]; DNA binding site 264730004284 RNA-binding motif; other site 264730004285 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264730004286 trimer interface [polypeptide binding]; other site 264730004287 active site 264730004288 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 264730004289 putative active site [active] 264730004290 putative metal binding site [ion binding]; other site 264730004291 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 264730004292 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264730004293 ATP binding site [chemical binding]; other site 264730004294 putative Mg++ binding site [ion binding]; other site 264730004295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730004296 nucleotide binding region [chemical binding]; other site 264730004297 ATP-binding site [chemical binding]; other site 264730004298 DEAD/H associated; Region: DEAD_assoc; pfam08494 264730004299 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 264730004300 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264730004301 Walker A/P-loop; other site 264730004302 ATP binding site [chemical binding]; other site 264730004303 Q-loop/lid; other site 264730004304 ABC transporter signature motif; other site 264730004305 Walker B; other site 264730004306 D-loop; other site 264730004307 H-loop/switch region; other site 264730004308 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 264730004309 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 264730004310 active site 264730004311 Zn binding site [ion binding]; other site 264730004312 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730004313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730004314 dimer interface [polypeptide binding]; other site 264730004315 conserved gate region; other site 264730004316 putative PBP binding loops; other site 264730004317 ABC-ATPase subunit interface; other site 264730004318 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730004319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730004320 dimer interface [polypeptide binding]; other site 264730004321 conserved gate region; other site 264730004322 putative PBP binding loops; other site 264730004323 ABC-ATPase subunit interface; other site 264730004324 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 264730004325 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730004326 substrate binding pocket [chemical binding]; other site 264730004327 membrane-bound complex binding site; other site 264730004328 hinge residues; other site 264730004329 ATP-dependent DNA ligase; Validated; Region: PRK09247 264730004330 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 264730004331 active site 264730004332 DNA binding site [nucleotide binding] 264730004333 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 264730004334 DNA binding site [nucleotide binding] 264730004335 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 264730004336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264730004337 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 264730004338 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 264730004339 active site 264730004340 SEC-C motif; Region: SEC-C; pfam02810 264730004341 LexA repressor; Validated; Region: PRK00215 264730004342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730004343 non-specific DNA binding site [nucleotide binding]; other site 264730004344 salt bridge; other site 264730004345 sequence-specific DNA binding site [nucleotide binding]; other site 264730004346 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264730004347 Catalytic site [active] 264730004348 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 264730004349 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 264730004350 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 264730004351 hypothetical protein; Provisional; Region: PRK00183 264730004352 SEC-C motif; Region: SEC-C; pfam02810 264730004353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730004354 Protein of unknown function (DUF1145); Region: DUF1145; pfam06611 264730004355 Purine nucleoside permease (NUP); Region: NUP; pfam06516 264730004356 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 264730004357 Predicted integral membrane protein [Function unknown]; Region: COG5615 264730004358 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 264730004359 DEAD/DEAH box helicase; Region: DEAD; pfam00270 264730004360 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 264730004361 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264730004362 Beta-lactamase; Region: Beta-lactamase; pfam00144 264730004363 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264730004364 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730004365 ligand binding site [chemical binding]; other site 264730004366 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 264730004367 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 264730004368 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 264730004369 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 264730004370 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 264730004371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730004372 Predicted membrane protein [Function unknown]; Region: COG3650 264730004373 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264730004374 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264730004375 Walker A/P-loop; other site 264730004376 ATP binding site [chemical binding]; other site 264730004377 Q-loop/lid; other site 264730004378 ABC transporter signature motif; other site 264730004379 Walker B; other site 264730004380 D-loop; other site 264730004381 H-loop/switch region; other site 264730004382 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 264730004383 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264730004384 Walker A/P-loop; other site 264730004385 ATP binding site [chemical binding]; other site 264730004386 Q-loop/lid; other site 264730004387 ABC transporter signature motif; other site 264730004388 Walker B; other site 264730004389 D-loop; other site 264730004390 H-loop/switch region; other site 264730004391 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 264730004392 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 264730004393 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264730004394 TM-ABC transporter signature motif; other site 264730004395 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730004396 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264730004397 TM-ABC transporter signature motif; other site 264730004398 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264730004399 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264730004400 dimerization interface [polypeptide binding]; other site 264730004401 ligand binding site [chemical binding]; other site 264730004402 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 264730004403 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 264730004404 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 264730004405 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 264730004406 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730004407 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730004408 metal binding site [ion binding]; metal-binding site 264730004409 active site 264730004410 I-site; other site 264730004411 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730004412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730004413 putative substrate translocation pore; other site 264730004414 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730004415 ATP-dependent helicase HepA; Validated; Region: PRK04914 264730004416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264730004417 ATP binding site [chemical binding]; other site 264730004418 putative Mg++ binding site [ion binding]; other site 264730004419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730004420 nucleotide binding region [chemical binding]; other site 264730004421 ATP-binding site [chemical binding]; other site 264730004422 Pectate lyase; Region: Pec_lyase_C; cl01593 264730004423 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 264730004424 dimer interaction site [polypeptide binding]; other site 264730004425 substrate-binding tunnel; other site 264730004426 active site 264730004427 catalytic site [active] 264730004428 substrate binding site [chemical binding]; other site 264730004429 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 264730004430 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 264730004431 acyl-activating enzyme (AAE) consensus motif; other site 264730004432 putative AMP binding site [chemical binding]; other site 264730004433 putative active site [active] 264730004434 putative CoA binding site [chemical binding]; other site 264730004435 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 264730004436 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 264730004437 acyl-activating enzyme (AAE) consensus motif; other site 264730004438 putative AMP binding site [chemical binding]; other site 264730004439 putative active site [active] 264730004440 putative CoA binding site [chemical binding]; other site 264730004441 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 264730004442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264730004443 ATP binding site [chemical binding]; other site 264730004444 putative Mg++ binding site [ion binding]; other site 264730004445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730004446 nucleotide binding region [chemical binding]; other site 264730004447 ATP-binding site [chemical binding]; other site 264730004448 Helicase associated domain (HA2); Region: HA2; pfam04408 264730004449 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 264730004450 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 264730004451 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 264730004452 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264730004453 dimer interface [polypeptide binding]; other site 264730004454 active site 264730004455 CoA binding pocket [chemical binding]; other site 264730004456 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264730004457 Substrate binding site [chemical binding]; other site 264730004458 Leucine rich repeat; Region: LRR_8; pfam13855 264730004459 Leucine rich repeat; Region: LRR_8; pfam13855 264730004460 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 264730004461 Protein of unknown function, DUF482; Region: DUF482; pfam04339 264730004462 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264730004463 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730004464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730004465 Walker A/P-loop; other site 264730004466 ATP binding site [chemical binding]; other site 264730004467 Q-loop/lid; other site 264730004468 ABC transporter signature motif; other site 264730004469 Walker B; other site 264730004470 D-loop; other site 264730004471 H-loop/switch region; other site 264730004472 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 264730004473 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 264730004474 substrate binding site [chemical binding]; other site 264730004475 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264730004476 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264730004477 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 264730004478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730004479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730004480 LysR substrate binding domain; Region: LysR_substrate; pfam03466 264730004481 dimerization interface [polypeptide binding]; other site 264730004482 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 264730004483 Right handed beta helix region; Region: Beta_helix; pfam13229 264730004484 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 264730004485 Cadherin repeat-like domain; Region: CA_like; cl15786 264730004486 Ca2+ binding site [ion binding]; other site 264730004487 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 264730004488 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264730004489 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264730004490 classical (c) SDRs; Region: SDR_c; cd05233 264730004491 NAD(P) binding site [chemical binding]; other site 264730004492 active site 264730004493 BRO family, N-terminal domain; Region: Bro-N; smart01040 264730004494 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730004495 MULE transposase domain; Region: MULE; pfam10551 264730004496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264730004497 Transposase; Region: HTH_Tnp_1; cl17663 264730004498 Transposase domain (DUF772); Region: DUF772; pfam05598 264730004499 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 264730004500 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 264730004501 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264730004502 RHS protein; Region: RHS; pfam03527 264730004503 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730004504 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264730004505 RHS protein; Region: RHS; pfam03527 264730004506 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730004507 Zinc-binding dehydrogenase; Region: ADH_zinc_N_2; pfam13602 264730004508 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 264730004509 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 264730004510 putative NAD(P) binding site [chemical binding]; other site 264730004511 active site 264730004512 Predicted transcriptional regulator [Transcription]; Region: COG2378 264730004513 HTH domain; Region: HTH_11; pfam08279 264730004514 WYL domain; Region: WYL; pfam13280 264730004515 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264730004516 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 264730004517 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264730004518 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264730004519 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264730004520 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264730004521 Surface antigen; Region: Bac_surface_Ag; pfam01103 264730004522 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264730004523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730004524 active site 264730004525 phosphorylation site [posttranslational modification] 264730004526 intermolecular recognition site; other site 264730004527 dimerization interface [polypeptide binding]; other site 264730004528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730004529 DNA binding site [nucleotide binding] 264730004530 two-component sensor protein; Provisional; Region: cpxA; PRK09470 264730004531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730004532 dimerization interface [polypeptide binding]; other site 264730004533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730004534 dimer interface [polypeptide binding]; other site 264730004535 phosphorylation site [posttranslational modification] 264730004536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730004537 ATP binding site [chemical binding]; other site 264730004538 Mg2+ binding site [ion binding]; other site 264730004539 G-X-G motif; other site 264730004540 helicase 45; Provisional; Region: PTZ00424 264730004541 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264730004542 ATP binding site [chemical binding]; other site 264730004543 Mg++ binding site [ion binding]; other site 264730004544 motif III; other site 264730004545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730004546 nucleotide binding region [chemical binding]; other site 264730004547 ATP-binding site [chemical binding]; other site 264730004548 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 264730004549 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 264730004550 S1 domain; Region: S1_2; pfam13509 264730004551 S1 domain; Region: S1_2; pfam13509 264730004552 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 264730004553 CsbD-like; Region: CsbD; pfam05532 264730004554 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 264730004555 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264730004556 active site 264730004557 catalytic residues [active] 264730004558 metal binding site [ion binding]; metal-binding site 264730004559 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 264730004560 Coenzyme A binding pocket [chemical binding]; other site 264730004561 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 264730004562 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264730004563 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264730004564 nucleoside/Zn binding site; other site 264730004565 dimer interface [polypeptide binding]; other site 264730004566 catalytic motif [active] 264730004567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730004568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730004569 PAS domain; Region: PAS_9; pfam13426 264730004570 putative active site [active] 264730004571 heme pocket [chemical binding]; other site 264730004572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730004573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730004574 dimer interface [polypeptide binding]; other site 264730004575 phosphorylation site [posttranslational modification] 264730004576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730004577 ATP binding site [chemical binding]; other site 264730004578 Mg2+ binding site [ion binding]; other site 264730004579 G-X-G motif; other site 264730004580 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 264730004581 GAF domain; Region: GAF; cl17456 264730004582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730004583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730004584 dimer interface [polypeptide binding]; other site 264730004585 phosphorylation site [posttranslational modification] 264730004586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730004587 ATP binding site [chemical binding]; other site 264730004588 Mg2+ binding site [ion binding]; other site 264730004589 G-X-G motif; other site 264730004590 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 264730004591 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 264730004592 Predicted membrane protein [Function unknown]; Region: COG3212 264730004593 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 264730004594 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264730004595 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730004596 N-terminal plug; other site 264730004597 ligand-binding site [chemical binding]; other site 264730004598 metabolite-proton symporter; Region: 2A0106; TIGR00883 264730004599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730004600 MASE2 domain; Region: MASE2; pfam05230 264730004601 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730004602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730004603 metal binding site [ion binding]; metal-binding site 264730004604 active site 264730004605 I-site; other site 264730004606 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730004607 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730004608 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730004609 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264730004610 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264730004611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730004612 putative substrate translocation pore; other site 264730004613 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730004614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730004615 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 264730004616 putative effector binding pocket; other site 264730004617 putative dimerization interface [polypeptide binding]; other site 264730004618 hypothetical protein; Provisional; Region: PRK11615 264730004619 VacJ like lipoprotein; Region: VacJ; cl01073 264730004620 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 264730004621 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264730004622 Predicted membrane protein [Function unknown]; Region: COG3162 264730004623 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264730004624 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 264730004625 Na binding site [ion binding]; other site 264730004626 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 264730004627 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 264730004628 short chain dehydrogenase; Provisional; Region: PRK05650 264730004629 classical (c) SDRs; Region: SDR_c; cd05233 264730004630 NAD(P) binding site [chemical binding]; other site 264730004631 active site 264730004632 hypothetical protein; Provisional; Region: PRK02237 264730004633 carbon storage regulator; Provisional; Region: PRK01712 264730004634 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730004635 MULE transposase domain; Region: MULE; pfam10551 264730004636 hypothetical protein; Provisional; Region: PRK00304 264730004637 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 264730004638 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 264730004639 putative oligomer interface [polypeptide binding]; other site 264730004640 putative active site [active] 264730004641 metal binding site [ion binding]; metal-binding site 264730004642 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 264730004643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730004644 Coenzyme A binding pocket [chemical binding]; other site 264730004645 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264730004646 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 264730004647 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 264730004648 active site 264730004649 dimer interface [polypeptide binding]; other site 264730004650 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 264730004651 Ligand Binding Site [chemical binding]; other site 264730004652 Molecular Tunnel; other site 264730004653 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 264730004654 substrate binding site [chemical binding]; other site 264730004655 catalytic residues [active] 264730004656 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 264730004657 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264730004658 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264730004659 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264730004660 Walker A/P-loop; other site 264730004661 ATP binding site [chemical binding]; other site 264730004662 Q-loop/lid; other site 264730004663 ABC transporter signature motif; other site 264730004664 Walker B; other site 264730004665 D-loop; other site 264730004666 H-loop/switch region; other site 264730004667 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 264730004668 Uncharacterized conserved protein [Function unknown]; Region: COG4121 264730004669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264730004670 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 264730004671 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 264730004672 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 264730004673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 264730004674 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 264730004675 yecA family protein; Region: ygfB_yecA; TIGR02292 264730004676 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 264730004677 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264730004678 ATP binding site [chemical binding]; other site 264730004679 putative Mg++ binding site [ion binding]; other site 264730004680 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730004681 nucleotide binding region [chemical binding]; other site 264730004682 ATP-binding site [chemical binding]; other site 264730004683 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 264730004684 HRDC domain; Region: HRDC; pfam00570 264730004685 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264730004686 MarR family; Region: MarR_2; pfam12802 264730004687 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264730004688 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 264730004689 DNA topoisomerase I; Validated; Region: PRK06599 264730004690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730004691 PAS domain; Region: PAS_9; pfam13426 264730004692 putative active site [active] 264730004693 heme pocket [chemical binding]; other site 264730004694 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730004695 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730004696 dimer interface [polypeptide binding]; other site 264730004697 putative CheW interface [polypeptide binding]; other site 264730004698 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 264730004699 catalytic triad [active] 264730004700 putative active site [active] 264730004701 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 264730004702 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 264730004703 hypothetical protein; Validated; Region: PRK09169 264730004704 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264730004705 synthetase active site [active] 264730004706 NTP binding site [chemical binding]; other site 264730004707 metal binding site [ion binding]; metal-binding site 264730004708 putative transposase OrfB; Reviewed; Region: PHA02517 264730004709 HTH-like domain; Region: HTH_21; pfam13276 264730004710 Integrase core domain; Region: rve; pfam00665 264730004711 Integrase core domain; Region: rve_3; cl15866 264730004712 Transposase; Region: HTH_Tnp_1; cl17663 264730004713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264730004714 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 264730004715 quinolinate synthetase; Provisional; Region: PRK09375 264730004716 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 264730004717 Peptidase family M48; Region: Peptidase_M48; cl12018 264730004718 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 264730004719 CPxP motif; other site 264730004720 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 264730004721 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264730004722 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264730004723 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 264730004724 catalytic triad [active] 264730004725 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 264730004726 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 264730004727 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 264730004728 dihydrodipicolinate synthase; Region: dapA; TIGR00674 264730004729 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 264730004730 dimer interface [polypeptide binding]; other site 264730004731 active site 264730004732 catalytic residue [active] 264730004733 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 264730004734 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 264730004735 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 264730004736 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 264730004737 ATP binding site [chemical binding]; other site 264730004738 active site 264730004739 substrate binding site [chemical binding]; other site 264730004740 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 264730004741 Predicted transcriptional regulator [Transcription]; Region: COG3905 264730004742 malate dehydrogenase; Provisional; Region: PRK13529 264730004743 Malic enzyme, N-terminal domain; Region: malic; pfam00390 264730004744 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 264730004745 NAD(P) binding site [chemical binding]; other site 264730004746 putative metal dependent hydrolase; Provisional; Region: PRK11598 264730004747 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 264730004748 Sulfatase; Region: Sulfatase; pfam00884 264730004749 ribonuclease D; Region: rnd; TIGR01388 264730004750 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 264730004751 catalytic site [active] 264730004752 putative active site [active] 264730004753 putative substrate binding site [chemical binding]; other site 264730004754 HRDC domain; Region: HRDC; pfam00570 264730004755 YcgL domain; Region: YcgL; cl01189 264730004756 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 264730004757 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264730004758 NAD binding site [chemical binding]; other site 264730004759 ligand binding site [chemical binding]; other site 264730004760 catalytic site [active] 264730004761 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 264730004762 putative FMN binding site [chemical binding]; other site 264730004763 hypothetical protein; Provisional; Region: PRK05170 264730004764 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 264730004765 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 264730004766 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 264730004767 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 264730004768 active site 264730004769 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264730004770 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264730004771 ligand binding site [chemical binding]; other site 264730004772 flexible hinge region; other site 264730004773 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 264730004774 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264730004775 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 264730004776 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 264730004777 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 264730004778 putative active site [active] 264730004779 putative dimer interface [polypeptide binding]; other site 264730004780 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 264730004781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 264730004782 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 264730004783 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264730004784 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264730004785 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264730004786 dimer interface [polypeptide binding]; other site 264730004787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730004788 catalytic residue [active] 264730004789 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 264730004790 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 264730004791 Na binding site [ion binding]; other site 264730004792 PAS domain; Region: PAS; smart00091 264730004793 PAS fold; Region: PAS_7; pfam12860 264730004794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730004795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730004796 dimer interface [polypeptide binding]; other site 264730004797 phosphorylation site [posttranslational modification] 264730004798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730004799 ATP binding site [chemical binding]; other site 264730004800 Mg2+ binding site [ion binding]; other site 264730004801 G-X-G motif; other site 264730004802 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730004803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730004804 active site 264730004805 phosphorylation site [posttranslational modification] 264730004806 intermolecular recognition site; other site 264730004807 dimerization interface [polypeptide binding]; other site 264730004808 H+ Antiporter protein; Region: 2A0121; TIGR00900 264730004809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730004810 putative substrate translocation pore; other site 264730004811 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264730004812 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264730004813 putative acyl-acceptor binding pocket; other site 264730004814 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 264730004815 Sodium Bile acid symporter family; Region: SBF; pfam01758 264730004816 recombination associated protein; Reviewed; Region: rdgC; PRK00321 264730004817 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264730004818 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264730004819 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 264730004820 dimer interface [polypeptide binding]; other site 264730004821 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264730004822 metal binding site [ion binding]; metal-binding site 264730004823 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 264730004824 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264730004825 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 264730004826 tartrate dehydrogenase; Region: TTC; TIGR02089 264730004827 transcriptional activator TtdR; Provisional; Region: PRK09801 264730004828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730004829 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 264730004830 putative effector binding pocket; other site 264730004831 putative dimerization interface [polypeptide binding]; other site 264730004832 Cupin domain; Region: Cupin_2; cl17218 264730004833 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 264730004834 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 264730004835 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 264730004836 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264730004837 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 264730004838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730004839 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264730004840 non-specific DNA binding site [nucleotide binding]; other site 264730004841 salt bridge; other site 264730004842 sequence-specific DNA binding site [nucleotide binding]; other site 264730004843 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730004844 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 264730004845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730004846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730004847 metal binding site [ion binding]; metal-binding site 264730004848 active site 264730004849 I-site; other site 264730004850 carboxy-terminal protease; Provisional; Region: PRK11186 264730004851 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264730004852 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264730004853 protein binding site [polypeptide binding]; other site 264730004854 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264730004855 Catalytic dyad [active] 264730004856 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 264730004857 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264730004858 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 264730004859 NAD(P) binding site [chemical binding]; other site 264730004860 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 264730004861 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264730004862 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 264730004863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730004864 Walker A/P-loop; other site 264730004865 ATP binding site [chemical binding]; other site 264730004866 Q-loop/lid; other site 264730004867 ABC transporter signature motif; other site 264730004868 Walker B; other site 264730004869 D-loop; other site 264730004870 H-loop/switch region; other site 264730004871 TOBE domain; Region: TOBE_2; pfam08402 264730004872 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264730004873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730004874 dimer interface [polypeptide binding]; other site 264730004875 conserved gate region; other site 264730004876 putative PBP binding loops; other site 264730004877 ABC-ATPase subunit interface; other site 264730004878 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264730004879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730004880 dimer interface [polypeptide binding]; other site 264730004881 conserved gate region; other site 264730004882 putative PBP binding loops; other site 264730004883 ABC-ATPase subunit interface; other site 264730004884 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 264730004885 PglZ domain; Region: PglZ; pfam08665 264730004886 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 264730004887 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 264730004888 transcriptional regulator protein; Region: phnR; TIGR03337 264730004889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730004890 DNA-binding site [nucleotide binding]; DNA binding site 264730004891 UTRA domain; Region: UTRA; pfam07702 264730004892 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730004893 MULE transposase domain; Region: MULE; pfam10551 264730004894 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 264730004895 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 264730004896 active site 264730004897 metal binding site [ion binding]; metal-binding site 264730004898 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730004899 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730004900 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730004901 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730004902 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730004903 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730004904 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264730004905 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264730004906 active site 264730004907 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 264730004908 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 264730004909 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 264730004910 Switch I; other site 264730004911 Switch II; other site 264730004912 septum formation inhibitor; Reviewed; Region: minC; PRK00339 264730004913 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 264730004914 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 264730004915 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 264730004916 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264730004917 putative acyl-acceptor binding pocket; other site 264730004918 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264730004919 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264730004920 active site 264730004921 nucleophile elbow; other site 264730004922 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264730004923 iron-sulfur cluster [ion binding]; other site 264730004924 [2Fe-2S] cluster binding site [ion binding]; other site 264730004925 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 264730004926 inhibitor site; inhibition site 264730004927 active site 264730004928 dimer interface [polypeptide binding]; other site 264730004929 catalytic residue [active] 264730004930 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264730004931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730004932 catalytic residue [active] 264730004933 Autoinducer synthetase; Region: Autoind_synth; pfam00765 264730004934 Autoinducer binding domain; Region: Autoind_bind; pfam03472 264730004935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730004936 DNA binding residues [nucleotide binding] 264730004937 dimerization interface [polypeptide binding]; other site 264730004938 MarR family; Region: MarR_2; pfam12802 264730004939 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264730004940 Pirin-related protein [General function prediction only]; Region: COG1741 264730004941 Pirin; Region: Pirin; pfam02678 264730004942 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 264730004943 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 264730004944 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 264730004945 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264730004946 active site 264730004947 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 264730004948 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264730004949 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 264730004950 putative C-terminal domain interface [polypeptide binding]; other site 264730004951 putative GSH binding site (G-site) [chemical binding]; other site 264730004952 putative dimer interface [polypeptide binding]; other site 264730004953 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 264730004954 putative N-terminal domain interface [polypeptide binding]; other site 264730004955 putative dimer interface [polypeptide binding]; other site 264730004956 putative substrate binding pocket (H-site) [chemical binding]; other site 264730004957 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264730004958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730004959 Walker A/P-loop; other site 264730004960 ATP binding site [chemical binding]; other site 264730004961 Q-loop/lid; other site 264730004962 ABC transporter signature motif; other site 264730004963 Walker B; other site 264730004964 D-loop; other site 264730004965 H-loop/switch region; other site 264730004966 inner membrane transport permease; Provisional; Region: PRK15066 264730004967 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264730004968 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264730004969 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264730004970 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264730004971 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 264730004972 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 264730004973 Uncharacterized conserved protein [Function unknown]; Region: COG2835 264730004974 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 264730004975 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 264730004976 Ligand binding site; other site 264730004977 oligomer interface; other site 264730004978 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 264730004979 FAD binding domain; Region: FAD_binding_4; pfam01565 264730004980 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 264730004981 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 264730004982 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 264730004983 homodimer interface [polypeptide binding]; other site 264730004984 oligonucleotide binding site [chemical binding]; other site 264730004985 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 264730004986 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 264730004987 RNA binding surface [nucleotide binding]; other site 264730004988 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264730004989 active site 264730004990 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 264730004991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730004992 motif II; other site 264730004993 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 264730004994 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 264730004995 tandem repeat interface [polypeptide binding]; other site 264730004996 oligomer interface [polypeptide binding]; other site 264730004997 active site residues [active] 264730004998 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264730004999 active site 264730005000 dimer interface [polypeptide binding]; other site 264730005001 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 264730005002 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 264730005003 putative phosphate acyltransferase; Provisional; Region: PRK05331 264730005004 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 264730005005 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264730005006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264730005007 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264730005008 NAD(P) binding site [chemical binding]; other site 264730005009 homotetramer interface [polypeptide binding]; other site 264730005010 homodimer interface [polypeptide binding]; other site 264730005011 active site 264730005012 acyl carrier protein; Provisional; Region: acpP; PRK00982 264730005013 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 264730005014 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264730005015 dimer interface [polypeptide binding]; other site 264730005016 active site 264730005017 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 264730005018 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 264730005019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730005020 catalytic residue [active] 264730005021 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 264730005022 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 264730005023 dimerization interface [polypeptide binding]; other site 264730005024 thymidylate kinase; Validated; Region: tmk; PRK00698 264730005025 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 264730005026 TMP-binding site; other site 264730005027 ATP-binding site [chemical binding]; other site 264730005028 DNA polymerase III subunit delta'; Validated; Region: PRK05707 264730005029 AAA ATPase domain; Region: AAA_16; pfam13191 264730005030 DNA polymerase III subunit delta'; Validated; Region: PRK08485 264730005031 PilZ domain; Region: PilZ; cl01260 264730005032 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264730005033 active site 264730005034 LysE type translocator; Region: LysE; cl00565 264730005035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730005036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730005037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 264730005038 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 264730005039 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 264730005040 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264730005041 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264730005042 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 264730005043 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 264730005044 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 264730005045 dimerization interface 3.5A [polypeptide binding]; other site 264730005046 active site 264730005047 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 264730005048 active site 264730005049 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 264730005050 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 264730005051 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 264730005052 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264730005053 Sporulation related domain; Region: SPOR; pfam05036 264730005054 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 264730005055 Colicin V production protein; Region: Colicin_V; cl00567 264730005056 amidophosphoribosyltransferase; Provisional; Region: PRK09246 264730005057 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 264730005058 active site 264730005059 tetramer interface [polypeptide binding]; other site 264730005060 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264730005061 active site 264730005062 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 264730005063 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264730005064 homodimer interface [polypeptide binding]; other site 264730005065 substrate-cofactor binding pocket; other site 264730005066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730005067 catalytic residue [active] 264730005068 oxidoreductase; Validated; Region: PRK05717 264730005069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730005070 NAD(P) binding site [chemical binding]; other site 264730005071 active site 264730005072 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 264730005073 threonine dehydratase; Reviewed; Region: PRK09224 264730005074 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 264730005075 tetramer interface [polypeptide binding]; other site 264730005076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730005077 catalytic residue [active] 264730005078 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 264730005079 putative Ile/Val binding site [chemical binding]; other site 264730005080 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 264730005081 putative Ile/Val binding site [chemical binding]; other site 264730005082 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264730005083 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264730005084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730005085 active site 264730005086 catalytic triad [active] 264730005087 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 264730005088 Predicted amidohydrolase [General function prediction only]; Region: COG0388 264730005089 dimer interface [polypeptide binding]; other site 264730005090 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 264730005091 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 264730005092 active site 264730005093 FMN binding site [chemical binding]; other site 264730005094 2,4-decadienoyl-CoA binding site; other site 264730005095 catalytic residue [active] 264730005096 4Fe-4S cluster binding site [ion binding]; other site 264730005097 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 264730005098 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730005099 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264730005100 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 264730005101 catalytic residue [active] 264730005102 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264730005103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730005104 putative substrate translocation pore; other site 264730005105 citrate-proton symporter; Provisional; Region: PRK15075 264730005106 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264730005107 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264730005108 putative active site [active] 264730005109 putative metal binding site [ion binding]; other site 264730005110 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 264730005111 substrate binding site [chemical binding]; other site 264730005112 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 264730005113 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264730005114 active site 264730005115 HIGH motif; other site 264730005116 nucleotide binding site [chemical binding]; other site 264730005117 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 264730005118 KMSKS motif; other site 264730005119 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 264730005120 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 264730005121 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264730005122 active site 264730005123 HIGH motif; other site 264730005124 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264730005125 KMSKS motif; other site 264730005126 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 264730005127 tRNA binding surface [nucleotide binding]; other site 264730005128 anticodon binding site; other site 264730005129 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 264730005130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730005131 Walker A motif; other site 264730005132 ATP binding site [chemical binding]; other site 264730005133 Walker B motif; other site 264730005134 arginine finger; other site 264730005135 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 264730005136 DNA-binding interface [nucleotide binding]; DNA binding site 264730005137 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 264730005138 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 264730005139 Walker A/P-loop; other site 264730005140 ATP binding site [chemical binding]; other site 264730005141 Q-loop/lid; other site 264730005142 ABC transporter signature motif; other site 264730005143 Walker B; other site 264730005144 D-loop; other site 264730005145 H-loop/switch region; other site 264730005146 TOBE domain; Region: TOBE_2; pfam08402 264730005147 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 264730005148 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 264730005149 Walker A/P-loop; other site 264730005150 ATP binding site [chemical binding]; other site 264730005151 Q-loop/lid; other site 264730005152 ABC transporter signature motif; other site 264730005153 Walker B; other site 264730005154 D-loop; other site 264730005155 H-loop/switch region; other site 264730005156 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 264730005157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730005158 dimer interface [polypeptide binding]; other site 264730005159 conserved gate region; other site 264730005160 putative PBP binding loops; other site 264730005161 ABC-ATPase subunit interface; other site 264730005162 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264730005163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730005164 dimer interface [polypeptide binding]; other site 264730005165 conserved gate region; other site 264730005166 putative PBP binding loops; other site 264730005167 ABC-ATPase subunit interface; other site 264730005168 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 264730005169 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 264730005170 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 264730005171 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 264730005172 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 264730005173 homodimer interface [polypeptide binding]; other site 264730005174 NADP binding site [chemical binding]; other site 264730005175 substrate binding site [chemical binding]; other site 264730005176 structural protein; Region: PHA01972 264730005177 Phage T7 tail fibre protein; Region: Phage_T7_tail; pfam03906 264730005178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264730005179 trigger factor; Provisional; Region: tig; PRK01490 264730005180 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264730005181 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 264730005182 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 264730005183 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 264730005184 oligomer interface [polypeptide binding]; other site 264730005185 active site residues [active] 264730005186 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 264730005187 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 264730005188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730005189 Walker A motif; other site 264730005190 ATP binding site [chemical binding]; other site 264730005191 Walker B motif; other site 264730005192 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 264730005193 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 264730005194 Found in ATP-dependent protease La (LON); Region: LON; smart00464 264730005195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730005196 Walker A motif; other site 264730005197 ATP binding site [chemical binding]; other site 264730005198 Walker B motif; other site 264730005199 arginine finger; other site 264730005200 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264730005201 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264730005202 IHF - DNA interface [nucleotide binding]; other site 264730005203 IHF dimer interface [polypeptide binding]; other site 264730005204 periplasmic folding chaperone; Provisional; Region: PRK10788 264730005205 SurA N-terminal domain; Region: SurA_N_3; pfam13624 264730005206 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264730005207 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 264730005208 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 264730005209 NAD binding site [chemical binding]; other site 264730005210 homotetramer interface [polypeptide binding]; other site 264730005211 homodimer interface [polypeptide binding]; other site 264730005212 substrate binding site [chemical binding]; other site 264730005213 active site 264730005214 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 264730005215 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730005216 Walker A/P-loop; other site 264730005217 ATP binding site [chemical binding]; other site 264730005218 Q-loop/lid; other site 264730005219 ABC transporter signature motif; other site 264730005220 Walker B; other site 264730005221 D-loop; other site 264730005222 H-loop/switch region; other site 264730005223 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 264730005224 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730005225 Walker A/P-loop; other site 264730005226 ATP binding site [chemical binding]; other site 264730005227 Q-loop/lid; other site 264730005228 ABC transporter signature motif; other site 264730005229 Walker B; other site 264730005230 D-loop; other site 264730005231 H-loop/switch region; other site 264730005232 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730005233 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 264730005234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730005235 dimer interface [polypeptide binding]; other site 264730005236 conserved gate region; other site 264730005237 putative PBP binding loops; other site 264730005238 ABC-ATPase subunit interface; other site 264730005239 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 264730005240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730005241 dimer interface [polypeptide binding]; other site 264730005242 conserved gate region; other site 264730005243 putative PBP binding loops; other site 264730005244 ABC-ATPase subunit interface; other site 264730005245 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 264730005246 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 264730005247 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 264730005248 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 264730005249 MltD lipid attachment motif; Region: MLTD_N; pfam06474 264730005250 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 264730005251 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264730005252 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264730005253 catalytic residue [active] 264730005254 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264730005255 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264730005256 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264730005257 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264730005258 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 264730005259 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264730005260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264730005261 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 264730005262 RNA/DNA hybrid binding site [nucleotide binding]; other site 264730005263 active site 264730005264 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 264730005265 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 264730005266 serine O-acetyltransferase; Region: cysE; TIGR01172 264730005267 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264730005268 trimer interface [polypeptide binding]; other site 264730005269 active site 264730005270 substrate binding site [chemical binding]; other site 264730005271 CoA binding site [chemical binding]; other site 264730005272 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 264730005273 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 264730005274 active site 264730005275 catalytic site [active] 264730005276 substrate binding site [chemical binding]; other site 264730005277 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264730005278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730005279 Coenzyme A binding pocket [chemical binding]; other site 264730005280 Predicted flavoprotein [General function prediction only]; Region: COG0431 264730005281 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264730005282 Peptidase M35 family; Region: M35_like; cl03449 264730005283 active site 264730005284 Zn binding site [ion binding]; other site 264730005285 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264730005286 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264730005287 active site 264730005288 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 264730005289 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264730005290 substrate binding site [chemical binding]; other site 264730005291 oxyanion hole (OAH) forming residues; other site 264730005292 trimer interface [polypeptide binding]; other site 264730005293 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 264730005294 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264730005295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730005296 putative substrate translocation pore; other site 264730005297 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 264730005298 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730005299 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730005300 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 264730005301 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 264730005302 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 264730005303 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 264730005304 Cl binding site [ion binding]; other site 264730005305 oligomer interface [polypeptide binding]; other site 264730005306 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264730005307 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264730005308 active site 264730005309 catalytic tetrad [active] 264730005310 Cache domain; Region: Cache_2; pfam08269 264730005311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730005312 dimerization interface [polypeptide binding]; other site 264730005313 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730005314 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730005315 dimer interface [polypeptide binding]; other site 264730005316 putative CheW interface [polypeptide binding]; other site 264730005317 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 264730005318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730005319 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 264730005320 PAS domain S-box; Region: sensory_box; TIGR00229 264730005321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730005322 putative active site [active] 264730005323 heme pocket [chemical binding]; other site 264730005324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730005325 PAS fold; Region: PAS_3; pfam08447 264730005326 putative active site [active] 264730005327 heme pocket [chemical binding]; other site 264730005328 PAS domain S-box; Region: sensory_box; TIGR00229 264730005329 PAS domain; Region: PAS_8; pfam13188 264730005330 PAS fold; Region: PAS_3; pfam08447 264730005331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730005332 putative active site [active] 264730005333 heme pocket [chemical binding]; other site 264730005334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730005335 dimer interface [polypeptide binding]; other site 264730005336 phosphorylation site [posttranslational modification] 264730005337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730005338 ATP binding site [chemical binding]; other site 264730005339 Mg2+ binding site [ion binding]; other site 264730005340 G-X-G motif; other site 264730005341 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730005342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730005343 active site 264730005344 phosphorylation site [posttranslational modification] 264730005345 intermolecular recognition site; other site 264730005346 dimerization interface [polypeptide binding]; other site 264730005347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730005348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730005349 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 264730005350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730005351 putative DNA binding site [nucleotide binding]; other site 264730005352 putative Zn2+ binding site [ion binding]; other site 264730005353 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730005354 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730005355 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730005356 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 264730005357 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730005358 N-terminal plug; other site 264730005359 ligand-binding site [chemical binding]; other site 264730005360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730005361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730005362 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 264730005363 putative effector binding pocket; other site 264730005364 putative dimerization interface [polypeptide binding]; other site 264730005365 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264730005366 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 264730005367 active site 264730005368 metal binding site [ion binding]; metal-binding site 264730005369 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264730005370 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 264730005371 putative C-terminal domain interface [polypeptide binding]; other site 264730005372 putative GSH binding site (G-site) [chemical binding]; other site 264730005373 putative dimer interface [polypeptide binding]; other site 264730005374 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 264730005375 putative N-terminal domain interface [polypeptide binding]; other site 264730005376 putative dimer interface [polypeptide binding]; other site 264730005377 putative substrate binding pocket (H-site) [chemical binding]; other site 264730005378 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 264730005379 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 264730005380 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 264730005381 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 264730005382 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264730005383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730005384 putative substrate translocation pore; other site 264730005385 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730005386 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730005387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264730005388 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730005389 dimer interface [polypeptide binding]; other site 264730005390 putative CheW interface [polypeptide binding]; other site 264730005391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264730005392 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264730005393 active site 264730005394 catalytic tetrad [active] 264730005395 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 264730005396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730005397 motif II; other site 264730005398 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 264730005399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730005400 Coenzyme A binding pocket [chemical binding]; other site 264730005401 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005402 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 264730005403 acyl-activating enzyme (AAE) consensus motif; other site 264730005404 AMP binding site [chemical binding]; other site 264730005405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005406 Condensation domain; Region: Condensation; pfam00668 264730005407 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005408 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 264730005409 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005410 acyl-activating enzyme (AAE) consensus motif; other site 264730005411 AMP binding site [chemical binding]; other site 264730005412 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005413 Condensation domain; Region: Condensation; pfam00668 264730005414 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005415 Nonribosomal peptide synthase; Region: NRPS; pfam08415 264730005416 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 264730005417 acyl-activating enzyme (AAE) consensus motif; other site 264730005418 AMP binding site [chemical binding]; other site 264730005419 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005420 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 264730005421 putative FMN binding site [chemical binding]; other site 264730005422 NADPH bind site [chemical binding]; other site 264730005423 Condensation domain; Region: Condensation; pfam00668 264730005424 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005425 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 264730005426 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005427 acyl-activating enzyme (AAE) consensus motif; other site 264730005428 AMP binding site [chemical binding]; other site 264730005429 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005430 Thioesterase domain; Region: Thioesterase; pfam00975 264730005431 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 264730005432 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 264730005433 acyl-activating enzyme (AAE) consensus motif; other site 264730005434 AMP binding site [chemical binding]; other site 264730005435 Condensation domain; Region: Condensation; pfam00668 264730005436 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 264730005437 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005438 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 264730005439 acyl-activating enzyme (AAE) consensus motif; other site 264730005440 AMP binding site [chemical binding]; other site 264730005441 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005442 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 264730005443 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 264730005444 active site 264730005445 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 264730005446 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 264730005447 putative NADP binding site [chemical binding]; other site 264730005448 active site 264730005449 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005450 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 264730005451 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264730005452 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264730005453 active site 264730005454 iron coordination sites [ion binding]; other site 264730005455 substrate binding pocket [chemical binding]; other site 264730005456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264730005457 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264730005458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730005459 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730005460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730005461 dimerization interface [polypeptide binding]; other site 264730005462 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730005463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730005464 dimer interface [polypeptide binding]; other site 264730005465 putative CheW interface [polypeptide binding]; other site 264730005466 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 264730005467 EamA-like transporter family; Region: EamA; pfam00892 264730005468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730005469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730005470 LysR substrate binding domain; Region: LysR_substrate; pfam03466 264730005471 dimerization interface [polypeptide binding]; other site 264730005472 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 264730005473 Predicted transcriptional regulator [Transcription]; Region: COG3905 264730005474 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 264730005475 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 264730005476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730005477 catalytic residue [active] 264730005478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730005479 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 264730005480 putative DNA binding site [nucleotide binding]; other site 264730005481 putative Zn2+ binding site [ion binding]; other site 264730005482 AsnC family; Region: AsnC_trans_reg; pfam01037 264730005483 Protein of unknown function (DUF808); Region: DUF808; pfam05661 264730005484 Predicted membrane protein [Function unknown]; Region: COG3748 264730005485 Protein of unknown function (DUF989); Region: DUF989; pfam06181 264730005486 Cytochrome c; Region: Cytochrom_C; pfam00034 264730005487 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 264730005488 ureidoglycolate hydrolase; Provisional; Region: PRK03606 264730005489 allantoicase; Provisional; Region: PRK13257 264730005490 Allantoicase repeat; Region: Allantoicase; pfam03561 264730005491 Allantoicase repeat; Region: Allantoicase; pfam03561 264730005492 OHCU decarboxylase; Region: UHCUDC; TIGR03164 264730005493 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 264730005494 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 264730005495 active site 264730005496 catalytic site [active] 264730005497 tetramer interface [polypeptide binding]; other site 264730005498 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 264730005499 active site 264730005500 homotetramer interface [polypeptide binding]; other site 264730005501 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730005502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730005503 DNA-binding site [nucleotide binding]; DNA binding site 264730005504 FCD domain; Region: FCD; pfam07729 264730005505 guanine deaminase; Provisional; Region: PRK09228 264730005506 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 264730005507 active site 264730005508 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264730005509 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 264730005510 XdhC Rossmann domain; Region: XdhC_C; pfam13478 264730005511 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 264730005512 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264730005513 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264730005514 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 264730005515 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264730005516 catalytic loop [active] 264730005517 iron binding site [ion binding]; other site 264730005518 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264730005519 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 264730005520 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264730005521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730005522 DNA-binding site [nucleotide binding]; DNA binding site 264730005523 FCD domain; Region: FCD; cl11656 264730005524 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264730005525 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 264730005526 Walker A/P-loop; other site 264730005527 ATP binding site [chemical binding]; other site 264730005528 Q-loop/lid; other site 264730005529 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 264730005530 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 264730005531 ABC transporter signature motif; other site 264730005532 Walker B; other site 264730005533 D-loop; other site 264730005534 H-loop/switch region; other site 264730005535 cell division protein ZipA; Reviewed; Region: zipA; PRK00269 264730005536 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 264730005537 FtsZ protein binding site [polypeptide binding]; other site 264730005538 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 264730005539 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 264730005540 nucleotide binding pocket [chemical binding]; other site 264730005541 K-X-D-G motif; other site 264730005542 catalytic site [active] 264730005543 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 264730005544 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 264730005545 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 264730005546 Dimer interface [polypeptide binding]; other site 264730005547 BRCT sequence motif; other site 264730005548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 264730005549 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 264730005550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730005551 Coenzyme A binding pocket [chemical binding]; other site 264730005552 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264730005553 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264730005554 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 264730005555 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 264730005556 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 264730005557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730005558 substrate binding pocket [chemical binding]; other site 264730005559 membrane-bound complex binding site; other site 264730005560 hinge residues; other site 264730005561 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 264730005562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730005563 Walker A motif; other site 264730005564 ATP binding site [chemical binding]; other site 264730005565 Walker B motif; other site 264730005566 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 264730005567 arginine finger; other site 264730005568 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 264730005569 hypothetical protein; Validated; Region: PRK00153 264730005570 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 264730005571 CPxP motif; other site 264730005572 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 264730005573 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 264730005574 ligand binding site [chemical binding]; other site 264730005575 NAD binding site [chemical binding]; other site 264730005576 catalytic site [active] 264730005577 homodimer interface [polypeptide binding]; other site 264730005578 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 264730005579 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730005580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730005581 Walker A/P-loop; other site 264730005582 ATP binding site [chemical binding]; other site 264730005583 Q-loop/lid; other site 264730005584 ABC transporter signature motif; other site 264730005585 Walker B; other site 264730005586 D-loop; other site 264730005587 H-loop/switch region; other site 264730005588 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 264730005589 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 264730005590 active site 264730005591 catalytic site [active] 264730005592 substrate binding site [chemical binding]; other site 264730005593 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 264730005594 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730005595 substrate binding pocket [chemical binding]; other site 264730005596 membrane-bound complex binding site; other site 264730005597 hinge residues; other site 264730005598 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 264730005599 ethanolamine permease; Region: 2A0305; TIGR00908 264730005600 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 264730005601 active site 264730005602 dimer interface [polypeptide binding]; other site 264730005603 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 264730005604 Prostaglandin dehydrogenases; Region: PGDH; cd05288 264730005605 NAD(P) binding site [chemical binding]; other site 264730005606 substrate binding site [chemical binding]; other site 264730005607 dimer interface [polypeptide binding]; other site 264730005608 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 264730005609 dimer interface [polypeptide binding]; other site 264730005610 catalytic triad [active] 264730005611 Benzoate membrane transport protein; Region: BenE; pfam03594 264730005612 benzoate transporter; Region: benE; TIGR00843 264730005613 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264730005614 MarR family; Region: MarR_2; pfam12802 264730005615 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264730005616 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 264730005617 putative C-terminal domain interface [polypeptide binding]; other site 264730005618 putative GSH binding site (G-site) [chemical binding]; other site 264730005619 putative dimer interface [polypeptide binding]; other site 264730005620 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 264730005621 N-terminal domain interface [polypeptide binding]; other site 264730005622 dimer interface [polypeptide binding]; other site 264730005623 substrate binding pocket (H-site) [chemical binding]; other site 264730005624 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 264730005625 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264730005626 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 264730005627 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 264730005628 GTP cyclohydrolase I; Provisional; Region: PLN03044 264730005629 homodecamer interface [polypeptide binding]; other site 264730005630 active site 264730005631 putative catalytic site residues [active] 264730005632 zinc binding site [ion binding]; other site 264730005633 GTP-CH-I/GFRP interaction surface; other site 264730005634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 264730005635 Smr domain; Region: Smr; pfam01713 264730005636 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 264730005637 Isochorismatase family; Region: Isochorismatase; pfam00857 264730005638 catalytic triad [active] 264730005639 conserved cis-peptide bond; other site 264730005640 HemK family putative methylases; Region: hemK_fam; TIGR00536 264730005641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730005642 S-adenosylmethionine binding site [chemical binding]; other site 264730005643 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 264730005644 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 264730005645 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 264730005646 Tetramer interface [polypeptide binding]; other site 264730005647 active site 264730005648 FMN-binding site [chemical binding]; other site 264730005649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730005650 putative substrate translocation pore; other site 264730005651 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 264730005652 intersubunit interface [polypeptide binding]; other site 264730005653 active site 264730005654 Zn2+ binding site [ion binding]; other site 264730005655 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 264730005656 Cupin domain; Region: Cupin_2; cl17218 264730005657 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 264730005658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730005659 motif II; other site 264730005660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730005661 DNA binding residues [nucleotide binding] 264730005662 dimerization interface [polypeptide binding]; other site 264730005663 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 264730005664 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 264730005665 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264730005666 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264730005667 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 264730005668 ZIP Zinc transporter; Region: Zip; pfam02535 264730005669 spermidine synthase; Provisional; Region: PRK00811 264730005670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730005671 S-adenosylmethionine binding site [chemical binding]; other site 264730005672 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 264730005673 Sulfatase; Region: Sulfatase; pfam00884 264730005674 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 264730005675 Uncharacterized conserved protein [Function unknown]; Region: COG2308 264730005676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 264730005677 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 264730005678 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264730005679 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 264730005680 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264730005681 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264730005682 active site residue [active] 264730005683 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 264730005684 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 264730005685 oligomer interface [polypeptide binding]; other site 264730005686 metal binding site [ion binding]; metal-binding site 264730005687 metal binding site [ion binding]; metal-binding site 264730005688 putative Cl binding site [ion binding]; other site 264730005689 basic sphincter; other site 264730005690 hydrophobic gate; other site 264730005691 periplasmic entrance; other site 264730005692 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264730005693 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 264730005694 substrate binding site [chemical binding]; other site 264730005695 oxyanion hole (OAH) forming residues; other site 264730005696 trimer interface [polypeptide binding]; other site 264730005697 conserved hypothetical protein; Region: TIGR02118 264730005698 Cytochrome c; Region: Cytochrom_C; cl11414 264730005699 Cupin domain; Region: Cupin_2; cl17218 264730005700 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 264730005701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730005702 AAA ATPase domain; Region: AAA_15; pfam13175 264730005703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264730005704 Transposase; Region: HTH_Tnp_1; pfam01527 264730005705 putative transposase OrfB; Reviewed; Region: PHA02517 264730005706 HTH-like domain; Region: HTH_21; pfam13276 264730005707 Integrase core domain; Region: rve; pfam00665 264730005708 Integrase core domain; Region: rve_3; pfam13683 264730005709 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264730005710 classical (c) SDRs; Region: SDR_c; cd05233 264730005711 NAD(P) binding site [chemical binding]; other site 264730005712 active site 264730005713 Isochorismatase family; Region: Isochorismatase; pfam00857 264730005714 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 264730005715 catalytic triad [active] 264730005716 conserved cis-peptide bond; other site 264730005717 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 264730005718 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264730005719 ATP binding site [chemical binding]; other site 264730005720 putative Mg++ binding site [ion binding]; other site 264730005721 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730005722 nucleotide binding region [chemical binding]; other site 264730005723 ATP-binding site [chemical binding]; other site 264730005724 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 264730005725 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 264730005726 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 264730005727 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264730005728 ATP binding site [chemical binding]; other site 264730005729 putative Mg++ binding site [ion binding]; other site 264730005730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730005731 nucleotide binding region [chemical binding]; other site 264730005732 ATP-binding site [chemical binding]; other site 264730005733 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 264730005734 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 264730005735 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 264730005736 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 264730005737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730005738 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730005739 putative substrate translocation pore; other site 264730005740 citrate-proton symporter; Provisional; Region: PRK15075 264730005741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730005742 putative substrate translocation pore; other site 264730005743 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 264730005744 ApbE family; Region: ApbE; pfam02424 264730005745 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 264730005746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264730005747 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264730005748 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 264730005749 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 264730005750 active site 264730005751 catalytic site [active] 264730005752 metal binding site [ion binding]; metal-binding site 264730005753 PilZ domain; Region: PilZ; pfam07238 264730005754 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 264730005755 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264730005756 FtsX-like permease family; Region: FtsX; pfam02687 264730005757 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 264730005758 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264730005759 Walker A/P-loop; other site 264730005760 ATP binding site [chemical binding]; other site 264730005761 Q-loop/lid; other site 264730005762 ABC transporter signature motif; other site 264730005763 Walker B; other site 264730005764 D-loop; other site 264730005765 H-loop/switch region; other site 264730005766 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 264730005767 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264730005768 FtsX-like permease family; Region: FtsX; pfam02687 264730005769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 264730005770 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 264730005771 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 264730005772 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 264730005773 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 264730005774 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 264730005775 PilZ domain; Region: PilZ; pfam07238 264730005776 Response regulator receiver domain; Region: Response_reg; pfam00072 264730005777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730005778 active site 264730005779 phosphorylation site [posttranslational modification] 264730005780 intermolecular recognition site; other site 264730005781 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264730005782 dimerization interface [polypeptide binding]; other site 264730005783 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264730005784 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264730005785 anti sigma factor interaction site; other site 264730005786 regulatory phosphorylation site [posttranslational modification]; other site 264730005787 transaldolase-like protein; Provisional; Region: PTZ00411 264730005788 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 264730005789 active site 264730005790 dimer interface [polypeptide binding]; other site 264730005791 catalytic residue [active] 264730005792 Secretin and TonB N terminus short domain; Region: STN; smart00965 264730005793 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 264730005794 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730005795 N-terminal plug; other site 264730005796 ligand-binding site [chemical binding]; other site 264730005797 glutamate carboxypeptidase; Reviewed; Region: PRK06133 264730005798 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 264730005799 metal binding site [ion binding]; metal-binding site 264730005800 dimer interface [polypeptide binding]; other site 264730005801 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264730005802 Catalytic site [active] 264730005803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730005804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730005805 dimer interface [polypeptide binding]; other site 264730005806 phosphorylation site [posttranslational modification] 264730005807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730005808 ATP binding site [chemical binding]; other site 264730005809 Mg2+ binding site [ion binding]; other site 264730005810 G-X-G motif; other site 264730005811 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730005812 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730005813 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730005814 lysogenic prophage region; PHAGE02 264730005815 Phage Tail Protein X; Region: Phage_tail_X; cl02088 264730005816 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 264730005817 Predicted chitinase [General function prediction only]; Region: COG3179 264730005818 catalytic residue [active] 264730005819 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 264730005820 Protein of unknown function (DUF796); Region: DUF796; pfam05638 264730005821 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730005822 MULE transposase domain; Region: MULE; pfam10551 264730005823 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 264730005824 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 264730005825 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 264730005826 Predicted chitinase [General function prediction only]; Region: COG3179 264730005827 catalytic residue [active] 264730005828 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 264730005829 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 264730005830 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 264730005831 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 264730005832 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 264730005833 catalytic residues [active] 264730005834 Int/Topo IB signature motif; other site 264730005835 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 264730005836 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264730005837 FMN binding site [chemical binding]; other site 264730005838 active site 264730005839 catalytic residues [active] 264730005840 substrate binding site [chemical binding]; other site 264730005841 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 264730005842 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 264730005843 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 264730005844 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 264730005845 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730005846 MULE transposase domain; Region: MULE; pfam10551 264730005847 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264730005848 Ligand Binding Site [chemical binding]; other site 264730005849 Response regulator receiver domain; Region: Response_reg; pfam00072 264730005850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730005851 active site 264730005852 phosphorylation site [posttranslational modification] 264730005853 intermolecular recognition site; other site 264730005854 dimerization interface [polypeptide binding]; other site 264730005855 CHASE3 domain; Region: CHASE3; pfam05227 264730005856 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264730005857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730005858 putative active site [active] 264730005859 heme pocket [chemical binding]; other site 264730005860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730005861 dimer interface [polypeptide binding]; other site 264730005862 phosphorylation site [posttranslational modification] 264730005863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730005864 ATP binding site [chemical binding]; other site 264730005865 Mg2+ binding site [ion binding]; other site 264730005866 G-X-G motif; other site 264730005867 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730005868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730005869 active site 264730005870 phosphorylation site [posttranslational modification] 264730005871 intermolecular recognition site; other site 264730005872 dimerization interface [polypeptide binding]; other site 264730005873 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730005874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730005875 active site 264730005876 phosphorylation site [posttranslational modification] 264730005877 intermolecular recognition site; other site 264730005878 dimerization interface [polypeptide binding]; other site 264730005879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730005880 DNA binding residues [nucleotide binding] 264730005881 dimerization interface [polypeptide binding]; other site 264730005882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264730005883 Histidine kinase; Region: HisKA_3; pfam07730 264730005884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730005885 ATP binding site [chemical binding]; other site 264730005886 Mg2+ binding site [ion binding]; other site 264730005887 G-X-G motif; other site 264730005888 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 264730005889 SnoaL-like domain; Region: SnoaL_3; pfam13474 264730005890 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 264730005891 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730005892 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730005893 DNA binding residues [nucleotide binding] 264730005894 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 264730005895 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 264730005896 nucleophilic elbow; other site 264730005897 catalytic triad; other site 264730005898 peptide synthase; Validated; Region: PRK05691 264730005899 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 264730005900 acyl-activating enzyme (AAE) consensus motif; other site 264730005901 active site 264730005902 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005903 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 264730005904 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005905 acyl-activating enzyme (AAE) consensus motif; other site 264730005906 AMP binding site [chemical binding]; other site 264730005907 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005908 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 264730005909 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005910 acyl-activating enzyme (AAE) consensus motif; other site 264730005911 AMP binding site [chemical binding]; other site 264730005912 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005913 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 264730005914 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005915 acyl-activating enzyme (AAE) consensus motif; other site 264730005916 AMP binding site [chemical binding]; other site 264730005917 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005918 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 264730005919 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730005920 inhibitor-cofactor binding pocket; inhibition site 264730005921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730005922 catalytic residue [active] 264730005923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 264730005924 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264730005925 intersubunit interface [polypeptide binding]; other site 264730005926 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 264730005927 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264730005928 ABC-ATPase subunit interface; other site 264730005929 dimer interface [polypeptide binding]; other site 264730005930 putative PBP binding regions; other site 264730005931 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 264730005932 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 264730005933 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 264730005934 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 264730005935 metal binding site [ion binding]; metal-binding site 264730005936 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 264730005937 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 264730005938 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 264730005939 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 264730005940 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 264730005941 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 264730005942 Condensation domain; Region: Condensation; pfam00668 264730005943 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005944 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 264730005945 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005946 acyl-activating enzyme (AAE) consensus motif; other site 264730005947 AMP binding site [chemical binding]; other site 264730005948 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005949 Condensation domain; Region: Condensation; pfam00668 264730005950 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005951 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 264730005952 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005953 acyl-activating enzyme (AAE) consensus motif; other site 264730005954 AMP binding site [chemical binding]; other site 264730005955 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005956 Condensation domain; Region: Condensation; pfam00668 264730005957 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005958 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 264730005959 Condensation domain; Region: Condensation; pfam00668 264730005960 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005961 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005962 acyl-activating enzyme (AAE) consensus motif; other site 264730005963 AMP binding site [chemical binding]; other site 264730005964 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005965 Condensation domain; Region: Condensation; pfam00668 264730005966 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005967 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 264730005968 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005969 acyl-activating enzyme (AAE) consensus motif; other site 264730005970 AMP binding site [chemical binding]; other site 264730005971 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005972 Condensation domain; Region: Condensation; pfam00668 264730005973 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005974 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 264730005975 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005976 acyl-activating enzyme (AAE) consensus motif; other site 264730005977 AMP binding site [chemical binding]; other site 264730005978 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005979 Condensation domain; Region: Condensation; pfam00668 264730005980 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005981 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 264730005982 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005983 acyl-activating enzyme (AAE) consensus motif; other site 264730005984 AMP binding site [chemical binding]; other site 264730005985 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005986 Condensation domain; Region: Condensation; pfam00668 264730005987 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730005988 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 264730005989 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 264730005990 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730005991 acyl-activating enzyme (AAE) consensus motif; other site 264730005992 AMP binding site [chemical binding]; other site 264730005993 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730005994 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 264730005995 Secretin and TonB N terminus short domain; Region: STN; smart00965 264730005996 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730005997 N-terminal plug; other site 264730005998 ligand-binding site [chemical binding]; other site 264730005999 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 264730006000 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730006001 N-terminal plug; other site 264730006002 ligand-binding site [chemical binding]; other site 264730006003 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 264730006004 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730006005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730006006 Walker A/P-loop; other site 264730006007 ATP binding site [chemical binding]; other site 264730006008 Q-loop/lid; other site 264730006009 ABC transporter signature motif; other site 264730006010 Walker B; other site 264730006011 D-loop; other site 264730006012 H-loop/switch region; other site 264730006013 Uncharacterized conserved protein [Function unknown]; Region: COG1262 264730006014 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264730006015 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 264730006016 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264730006017 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730006018 catalytic residue [active] 264730006019 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 264730006020 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 264730006021 active site 264730006022 dimer interface [polypeptide binding]; other site 264730006023 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264730006024 calcium-activated chloride channel protein 1; Region: hCaCC; TIGR00868 264730006025 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264730006026 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 264730006027 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264730006028 Walker A/P-loop; other site 264730006029 ATP binding site [chemical binding]; other site 264730006030 Q-loop/lid; other site 264730006031 ABC transporter signature motif; other site 264730006032 Walker B; other site 264730006033 D-loop; other site 264730006034 H-loop/switch region; other site 264730006035 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264730006036 FtsX-like permease family; Region: FtsX; pfam02687 264730006037 macrolide transporter subunit MacA; Provisional; Region: PRK11578 264730006038 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264730006039 E3 interaction surface; other site 264730006040 lipoyl attachment site [posttranslational modification]; other site 264730006041 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730006042 Penicillin amidase; Region: Penicil_amidase; pfam01804 264730006043 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 264730006044 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 264730006045 active site 264730006046 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 264730006047 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 264730006048 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730006049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730006050 homodimer interface [polypeptide binding]; other site 264730006051 catalytic residue [active] 264730006052 excinuclease ABC subunit B; Provisional; Region: PRK05298 264730006053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264730006054 ATP binding site [chemical binding]; other site 264730006055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730006056 nucleotide binding region [chemical binding]; other site 264730006057 ATP-binding site [chemical binding]; other site 264730006058 Ultra-violet resistance protein B; Region: UvrB; pfam12344 264730006059 UvrB/uvrC motif; Region: UVR; pfam02151 264730006060 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 264730006061 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264730006062 HIGH motif; other site 264730006063 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264730006064 active site 264730006065 KMSKS motif; other site 264730006066 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264730006067 active site 264730006068 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 264730006069 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264730006070 FMN binding site [chemical binding]; other site 264730006071 active site 264730006072 catalytic residues [active] 264730006073 substrate binding site [chemical binding]; other site 264730006074 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264730006075 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 264730006076 putative dimer interface [polypeptide binding]; other site 264730006077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730006078 PAS fold; Region: PAS_3; pfam08447 264730006079 putative active site [active] 264730006080 heme pocket [chemical binding]; other site 264730006081 PAS domain S-box; Region: sensory_box; TIGR00229 264730006082 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730006083 putative active site [active] 264730006084 heme pocket [chemical binding]; other site 264730006085 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730006086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730006087 metal binding site [ion binding]; metal-binding site 264730006088 active site 264730006089 I-site; other site 264730006090 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730006091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730006092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730006093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264730006094 dimerization interface [polypeptide binding]; other site 264730006095 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 264730006096 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 264730006097 substrate binding site [chemical binding]; other site 264730006098 ligand binding site [chemical binding]; other site 264730006099 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 264730006100 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 264730006101 substrate binding site [chemical binding]; other site 264730006102 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 264730006103 tartrate dehydrogenase; Region: TTC; TIGR02089 264730006104 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 264730006105 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264730006106 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 264730006107 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 264730006108 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 264730006109 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 264730006110 active site 264730006111 intersubunit interface [polypeptide binding]; other site 264730006112 catalytic residue [active] 264730006113 galactonate dehydratase; Provisional; Region: PRK14017 264730006114 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 264730006115 putative active site pocket [active] 264730006116 putative metal binding site [ion binding]; other site 264730006117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730006118 D-galactonate transporter; Region: 2A0114; TIGR00893 264730006119 putative substrate translocation pore; other site 264730006120 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264730006121 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264730006122 Bacterial transcriptional regulator; Region: IclR; pfam01614 264730006123 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 264730006124 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 264730006125 putative NAD(P) binding site [chemical binding]; other site 264730006126 putative substrate binding site [chemical binding]; other site 264730006127 catalytic Zn binding site [ion binding]; other site 264730006128 structural Zn binding site [ion binding]; other site 264730006129 dimer interface [polypeptide binding]; other site 264730006130 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 264730006131 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264730006132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730006133 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 264730006134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264730006135 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 264730006136 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 264730006137 Ligand binding site [chemical binding]; other site 264730006138 Electron transfer flavoprotein domain; Region: ETF; pfam01012 264730006139 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 264730006140 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 264730006141 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 264730006142 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730006143 substrate binding pocket [chemical binding]; other site 264730006144 membrane-bound complex binding site; other site 264730006145 hinge residues; other site 264730006146 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 264730006147 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264730006148 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730006149 ligand binding site [chemical binding]; other site 264730006150 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264730006151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730006152 DNA-binding site [nucleotide binding]; DNA binding site 264730006153 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730006154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730006155 homodimer interface [polypeptide binding]; other site 264730006156 catalytic residue [active] 264730006157 Flagellin N-methylase; Region: FliB; cl00497 264730006158 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264730006159 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264730006160 hydrophobic ligand binding site; other site 264730006161 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 264730006162 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264730006163 dimer interface [polypeptide binding]; other site 264730006164 active site 264730006165 citrylCoA binding site [chemical binding]; other site 264730006166 NADH binding [chemical binding]; other site 264730006167 cationic pore residues; other site 264730006168 oxalacetate/citrate binding site [chemical binding]; other site 264730006169 coenzyme A binding site [chemical binding]; other site 264730006170 catalytic triad [active] 264730006171 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 264730006172 Iron-sulfur protein interface; other site 264730006173 proximal quinone binding site [chemical binding]; other site 264730006174 SdhD (CybS) interface [polypeptide binding]; other site 264730006175 proximal heme binding site [chemical binding]; other site 264730006176 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 264730006177 SdhC subunit interface [polypeptide binding]; other site 264730006178 proximal heme binding site [chemical binding]; other site 264730006179 cardiolipin binding site; other site 264730006180 Iron-sulfur protein interface; other site 264730006181 proximal quinone binding site [chemical binding]; other site 264730006182 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 264730006183 L-aspartate oxidase; Provisional; Region: PRK06175 264730006184 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264730006185 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 264730006186 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 264730006187 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 264730006188 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 264730006189 TPP-binding site [chemical binding]; other site 264730006190 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 264730006191 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 264730006192 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264730006193 E3 interaction surface; other site 264730006194 lipoyl attachment site [posttranslational modification]; other site 264730006195 e3 binding domain; Region: E3_binding; pfam02817 264730006196 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 264730006197 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 264730006198 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 264730006199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264730006200 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264730006201 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 264730006202 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 264730006203 CoA-ligase; Region: Ligase_CoA; pfam00549 264730006204 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 264730006205 CoA binding domain; Region: CoA_binding; pfam02629 264730006206 CoA-ligase; Region: Ligase_CoA; pfam00549 264730006207 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 264730006208 heat shock protein 90; Provisional; Region: PRK05218 264730006209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730006210 ATP binding site [chemical binding]; other site 264730006211 Mg2+ binding site [ion binding]; other site 264730006212 G-X-G motif; other site 264730006213 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264730006214 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 264730006215 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264730006216 dimer interface [polypeptide binding]; other site 264730006217 active site 264730006218 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 264730006219 active site 1 [active] 264730006220 dimer interface [polypeptide binding]; other site 264730006221 active site 2 [active] 264730006222 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730006223 MULE transposase domain; Region: MULE; pfam10551 264730006224 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 264730006225 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 264730006226 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 264730006227 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 264730006228 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264730006229 catalytic core [active] 264730006230 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264730006231 CoenzymeA binding site [chemical binding]; other site 264730006232 subunit interaction site [polypeptide binding]; other site 264730006233 PHB binding site; other site 264730006234 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264730006235 LamB/YcsF family; Region: LamB_YcsF; pfam03746 264730006236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730006237 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264730006238 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 264730006239 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264730006240 EF-hand domain pair; Region: EF_hand_6; pfam13833 264730006241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730006242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730006243 dimerization interface [polypeptide binding]; other site 264730006244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730006245 dimer interface [polypeptide binding]; other site 264730006246 phosphorylation site [posttranslational modification] 264730006247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730006248 ATP binding site [chemical binding]; other site 264730006249 Mg2+ binding site [ion binding]; other site 264730006250 G-X-G motif; other site 264730006251 osmolarity response regulator; Provisional; Region: ompR; PRK09468 264730006252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730006253 active site 264730006254 phosphorylation site [posttranslational modification] 264730006255 intermolecular recognition site; other site 264730006256 dimerization interface [polypeptide binding]; other site 264730006257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730006258 DNA binding site [nucleotide binding] 264730006259 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730006260 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730006261 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730006262 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 264730006263 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 264730006264 PapC N-terminal domain; Region: PapC_N; pfam13954 264730006265 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 264730006266 PapC C-terminal domain; Region: PapC_C; pfam13953 264730006267 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 264730006268 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 264730006269 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 264730006270 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 264730006271 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730006272 MULE transposase domain; Region: MULE; pfam10551 264730006273 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730006274 DNA binding residues [nucleotide binding] 264730006275 dimerization interface [polypeptide binding]; other site 264730006276 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 264730006277 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 264730006278 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264730006279 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 264730006280 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 264730006281 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 264730006282 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 264730006283 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 264730006284 Ligand Binding Site [chemical binding]; other site 264730006285 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 264730006286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730006287 dimer interface [polypeptide binding]; other site 264730006288 phosphorylation site [posttranslational modification] 264730006289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730006290 ATP binding site [chemical binding]; other site 264730006291 Mg2+ binding site [ion binding]; other site 264730006292 G-X-G motif; other site 264730006293 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 264730006294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730006295 active site 264730006296 phosphorylation site [posttranslational modification] 264730006297 intermolecular recognition site; other site 264730006298 dimerization interface [polypeptide binding]; other site 264730006299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730006300 DNA binding site [nucleotide binding] 264730006301 MoxR-like ATPases [General function prediction only]; Region: COG0714 264730006302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730006303 Walker A motif; other site 264730006304 ATP binding site [chemical binding]; other site 264730006305 Walker B motif; other site 264730006306 arginine finger; other site 264730006307 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 264730006308 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 264730006309 Protein of unknown function DUF58; Region: DUF58; pfam01882 264730006310 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 264730006311 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264730006312 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264730006313 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 264730006314 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 264730006315 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 264730006316 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 264730006317 active site 264730006318 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264730006319 active site 2 [active] 264730006320 active site 1 [active] 264730006321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730006322 dimerization interface [polypeptide binding]; other site 264730006323 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730006324 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730006325 dimer interface [polypeptide binding]; other site 264730006326 putative CheW interface [polypeptide binding]; other site 264730006327 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264730006328 active site 264730006329 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730006330 substrate binding pocket [chemical binding]; other site 264730006331 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 264730006332 membrane-bound complex binding site; other site 264730006333 hinge residues; other site 264730006334 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 264730006335 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264730006336 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264730006337 catalytic residue [active] 264730006338 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 264730006339 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264730006340 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264730006341 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 264730006342 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 264730006343 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264730006344 Walker A/P-loop; other site 264730006345 ATP binding site [chemical binding]; other site 264730006346 Q-loop/lid; other site 264730006347 ABC transporter signature motif; other site 264730006348 Walker B; other site 264730006349 D-loop; other site 264730006350 H-loop/switch region; other site 264730006351 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 264730006352 active site 264730006353 catalytic triad [active] 264730006354 oxyanion hole [active] 264730006355 switch loop; other site 264730006356 L,D-transpeptidase; Provisional; Region: PRK10260 264730006357 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264730006358 Predicted acetyltransferase [General function prediction only]; Region: COG2388 264730006359 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 264730006360 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264730006361 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 264730006362 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 264730006363 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 264730006364 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 264730006365 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264730006366 Ligand Binding Site [chemical binding]; other site 264730006367 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 264730006368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730006369 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 264730006370 substrate binding site [chemical binding]; other site 264730006371 dimerization interface [polypeptide binding]; other site 264730006372 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 264730006373 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 264730006374 Active Sites [active] 264730006375 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 264730006376 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 264730006377 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 264730006378 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 264730006379 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 264730006380 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 264730006381 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 264730006382 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 264730006383 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 264730006384 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 264730006385 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264730006386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730006387 DNA-binding site [nucleotide binding]; DNA binding site 264730006388 FCD domain; Region: FCD; pfam07729 264730006389 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 264730006390 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264730006391 tetramer interface [polypeptide binding]; other site 264730006392 active site 264730006393 Mg2+/Mn2+ binding site [ion binding]; other site 264730006394 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264730006395 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 264730006396 dimer interface [polypeptide binding]; other site 264730006397 active site 264730006398 citrylCoA binding site [chemical binding]; other site 264730006399 oxalacetate/citrate binding site [chemical binding]; other site 264730006400 coenzyme A binding site [chemical binding]; other site 264730006401 catalytic triad [active] 264730006402 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 264730006403 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 264730006404 substrate binding site [chemical binding]; other site 264730006405 ligand binding site [chemical binding]; other site 264730006406 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 264730006407 substrate binding site [chemical binding]; other site 264730006408 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 264730006409 PEP synthetase regulatory protein; Provisional; Region: PRK05339 264730006410 phosphoenolpyruvate synthase; Validated; Region: PRK06464 264730006411 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264730006412 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264730006413 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264730006414 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264730006415 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730006416 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 264730006417 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 264730006418 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 264730006419 Cl binding site [ion binding]; other site 264730006420 oligomer interface [polypeptide binding]; other site 264730006421 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 264730006422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730006423 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730006424 DNA binding residues [nucleotide binding] 264730006425 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 264730006426 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264730006427 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730006428 ligand binding site [chemical binding]; other site 264730006429 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 264730006430 active site 264730006431 SAM binding site [chemical binding]; other site 264730006432 homodimer interface [polypeptide binding]; other site 264730006433 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 264730006434 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 264730006435 [4Fe-4S] binding site [ion binding]; other site 264730006436 molybdopterin cofactor binding site; other site 264730006437 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 264730006438 molybdopterin cofactor binding site; other site 264730006439 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 264730006440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 264730006441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264730006442 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 264730006443 active site 264730006444 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264730006445 active site 264730006446 ATP binding site [chemical binding]; other site 264730006447 substrate binding site [chemical binding]; other site 264730006448 activation loop (A-loop); other site 264730006449 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 264730006450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730006451 putative substrate translocation pore; other site 264730006452 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 264730006453 active site 264730006454 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 264730006455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730006456 active site 264730006457 phosphorylation site [posttranslational modification] 264730006458 intermolecular recognition site; other site 264730006459 dimerization interface [polypeptide binding]; other site 264730006460 ANTAR domain; Region: ANTAR; pfam03861 264730006461 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264730006462 NMT1-like family; Region: NMT1_2; pfam13379 264730006463 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 264730006464 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 264730006465 quinone interaction residues [chemical binding]; other site 264730006466 active site 264730006467 catalytic residues [active] 264730006468 FMN binding site [chemical binding]; other site 264730006469 substrate binding site [chemical binding]; other site 264730006470 Ribosome modulation factor; Region: RMF; pfam04957 264730006471 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 264730006472 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 264730006473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264730006474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730006475 S-adenosylmethionine binding site [chemical binding]; other site 264730006476 CHASE domain; Region: CHASE; pfam03924 264730006477 PAS domain S-box; Region: sensory_box; TIGR00229 264730006478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730006479 putative active site [active] 264730006480 heme pocket [chemical binding]; other site 264730006481 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730006482 PAS fold; Region: PAS_3; pfam08447 264730006483 putative active site [active] 264730006484 heme pocket [chemical binding]; other site 264730006485 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730006486 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730006487 metal binding site [ion binding]; metal-binding site 264730006488 active site 264730006489 I-site; other site 264730006490 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 264730006491 hypothetical protein; Provisional; Region: PRK11702 264730006492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730006493 intermolecular recognition site; other site 264730006494 active site 264730006495 dimerization interface [polypeptide binding]; other site 264730006496 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264730006497 putative binding surface; other site 264730006498 active site 264730006499 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730006500 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 264730006501 dimer interface [polypeptide binding]; other site 264730006502 active site 264730006503 Int/Topo IB signature motif; other site 264730006504 Predicted chitinase [General function prediction only]; Region: COG3179 264730006505 catalytic residue [active] 264730006506 MULE transposase domain; Region: MULE; pfam10551 264730006507 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 264730006508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264730006509 Zn2+ binding site [ion binding]; other site 264730006510 Mg2+ binding site [ion binding]; other site 264730006511 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 264730006512 Predicted membrane protein [Function unknown]; Region: COG5393 264730006513 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 264730006514 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 264730006515 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 264730006516 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264730006517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730006518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730006519 dimerization interface [polypeptide binding]; other site 264730006520 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 264730006521 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 264730006522 active site 264730006523 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 264730006524 heterodimer interface [polypeptide binding]; other site 264730006525 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 264730006526 active site 264730006527 benzoate transport; Region: 2A0115; TIGR00895 264730006528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730006529 putative substrate translocation pore; other site 264730006530 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 264730006531 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 264730006532 tetramer interface [polypeptide binding]; other site 264730006533 active site 264730006534 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 264730006535 outer membrane porin, OprD family; Region: OprD; pfam03573 264730006536 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264730006537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730006538 D-galactonate transporter; Region: 2A0114; TIGR00893 264730006539 putative substrate translocation pore; other site 264730006540 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 264730006541 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 264730006542 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 264730006543 dimer interface [polypeptide binding]; other site 264730006544 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 264730006545 active site 264730006546 Fe binding site [ion binding]; other site 264730006547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730006548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730006549 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 264730006550 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264730006551 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264730006552 shikimate binding site; other site 264730006553 NAD(P) binding site [chemical binding]; other site 264730006554 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264730006555 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 264730006556 probable active site [active] 264730006557 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 264730006558 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 264730006559 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 264730006560 GTP binding site; other site 264730006561 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 264730006562 MPT binding site; other site 264730006563 trimer interface [polypeptide binding]; other site 264730006564 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 264730006565 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 264730006566 dimer interface [polypeptide binding]; other site 264730006567 putative functional site; other site 264730006568 putative MPT binding site; other site 264730006569 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264730006570 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 264730006571 active site 264730006572 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 264730006573 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 264730006574 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 264730006575 TrkA-N domain; Region: TrkA_N; pfam02254 264730006576 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 264730006577 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 264730006578 FecR protein; Region: FecR; pfam04773 264730006579 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 264730006580 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 264730006581 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264730006582 active site 264730006583 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 264730006584 DNA-specific endonuclease I; Provisional; Region: PRK15137 264730006585 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 264730006586 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 264730006587 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 264730006588 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264730006589 ligand binding site [chemical binding]; other site 264730006590 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 264730006591 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264730006592 Walker A/P-loop; other site 264730006593 ATP binding site [chemical binding]; other site 264730006594 Q-loop/lid; other site 264730006595 ABC transporter signature motif; other site 264730006596 Walker B; other site 264730006597 D-loop; other site 264730006598 H-loop/switch region; other site 264730006599 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264730006600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730006601 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264730006602 TM-ABC transporter signature motif; other site 264730006603 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264730006604 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264730006605 DNA binding site [nucleotide binding] 264730006606 domain linker motif; other site 264730006607 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264730006608 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264730006609 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 264730006610 substrate binding site [chemical binding]; other site 264730006611 dimer interface [polypeptide binding]; other site 264730006612 ATP binding site [chemical binding]; other site 264730006613 D-ribose pyranase; Provisional; Region: PRK11797 264730006614 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 264730006615 active site 264730006616 tetramer interface [polypeptide binding]; other site 264730006617 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264730006618 DNA-binding site [nucleotide binding]; DNA binding site 264730006619 RNA-binding motif; other site 264730006620 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 264730006621 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 264730006622 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 264730006623 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 264730006624 active site 264730006625 dimer interface [polypeptide binding]; other site 264730006626 motif 1; other site 264730006627 motif 2; other site 264730006628 motif 3; other site 264730006629 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 264730006630 anticodon binding site; other site 264730006631 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 264730006632 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 264730006633 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 264730006634 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 264730006635 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 264730006636 23S rRNA binding site [nucleotide binding]; other site 264730006637 L21 binding site [polypeptide binding]; other site 264730006638 L13 binding site [polypeptide binding]; other site 264730006639 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 264730006640 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 264730006641 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 264730006642 dimer interface [polypeptide binding]; other site 264730006643 motif 1; other site 264730006644 active site 264730006645 motif 2; other site 264730006646 motif 3; other site 264730006647 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 264730006648 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 264730006649 putative tRNA-binding site [nucleotide binding]; other site 264730006650 B3/4 domain; Region: B3_4; pfam03483 264730006651 tRNA synthetase B5 domain; Region: B5; smart00874 264730006652 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 264730006653 dimer interface [polypeptide binding]; other site 264730006654 motif 1; other site 264730006655 motif 3; other site 264730006656 motif 2; other site 264730006657 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 264730006658 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264730006659 IHF dimer interface [polypeptide binding]; other site 264730006660 IHF - DNA interface [nucleotide binding]; other site 264730006661 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 264730006662 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 264730006663 DNA binding residues [nucleotide binding] 264730006664 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730006665 DNA binding site [nucleotide binding] 264730006666 active site 264730006667 Int/Topo IB signature motif; other site 264730006668 lysogenic prophage region; PHAGE03 264730006669 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730006670 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730006671 DNA binding residues [nucleotide binding] 264730006672 dimerization interface [polypeptide binding]; other site 264730006673 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 264730006674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730006675 non-specific DNA binding site [nucleotide binding]; other site 264730006676 sequence-specific DNA binding site [nucleotide binding]; other site 264730006677 salt bridge; other site 264730006678 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264730006679 Predicted transcriptional regulator [Transcription]; Region: COG2932 264730006680 Catalytic site [active] 264730006681 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264730006682 Helix-turn-helix domain; Region: HTH_36; pfam13730 264730006683 Phage-related protein, tail component [Function unknown]; Region: COG4723 264730006684 Phage-related protein, tail component [Function unknown]; Region: COG4733 264730006685 Putative phage tail protein; Region: Phage-tail_3; pfam13550 264730006686 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730006687 MULE transposase domain; Region: MULE; pfam10551 264730006688 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 264730006689 active site 264730006690 catalytic residues [active] 264730006691 metal binding site [ion binding]; metal-binding site 264730006692 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 264730006693 tartrate dehydrogenase; Region: TTC; TIGR02089 264730006694 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 264730006695 hypothetical protein; Validated; Region: PRK06201 264730006696 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 264730006697 Nitronate monooxygenase; Region: NMO; pfam03060 264730006698 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264730006699 FMN binding site [chemical binding]; other site 264730006700 substrate binding site [chemical binding]; other site 264730006701 putative catalytic residue [active] 264730006702 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264730006703 active site 264730006704 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 264730006705 dimer interface [polypeptide binding]; other site 264730006706 non-prolyl cis peptide bond; other site 264730006707 insertion regions; other site 264730006708 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 264730006709 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 264730006710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730006711 putative substrate translocation pore; other site 264730006712 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730006713 MULE transposase domain; Region: MULE; pfam10551 264730006714 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 264730006715 C-terminal domain interface [polypeptide binding]; other site 264730006716 GSH binding site (G-site) [chemical binding]; other site 264730006717 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264730006718 dimer interface [polypeptide binding]; other site 264730006719 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 264730006720 N-terminal domain interface [polypeptide binding]; other site 264730006721 dimer interface [polypeptide binding]; other site 264730006722 substrate binding pocket (H-site) [chemical binding]; other site 264730006723 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 264730006724 type II secretion system protein J; Region: gspJ; TIGR01711 264730006725 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 264730006726 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 264730006727 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 264730006728 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 264730006729 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 264730006730 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 264730006731 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 264730006732 GspL periplasmic domain; Region: GspL_C; cl14909 264730006733 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 264730006734 type II secretion system protein D; Region: type_II_gspD; TIGR02517 264730006735 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264730006736 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264730006737 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264730006738 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264730006739 type II secretion system protein E; Region: type_II_gspE; TIGR02533 264730006740 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264730006741 Walker A motif; other site 264730006742 ATP binding site [chemical binding]; other site 264730006743 Walker B motif; other site 264730006744 type II secretion system protein F; Region: GspF; TIGR02120 264730006745 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264730006746 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264730006747 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 264730006748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730006749 ATP binding site [chemical binding]; other site 264730006750 G-X-G motif; other site 264730006751 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 264730006752 active site 264730006753 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 264730006754 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 264730006755 putative amidase; Provisional; Region: PRK06169 264730006756 Amidase; Region: Amidase; pfam01425 264730006757 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264730006758 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 264730006759 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264730006760 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 264730006761 substrate binding site [chemical binding]; other site 264730006762 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 264730006763 Na binding site [ion binding]; other site 264730006764 Pirin-related protein [General function prediction only]; Region: COG1741 264730006765 Pirin; Region: Pirin; pfam02678 264730006766 LysR family transcriptional regulator; Provisional; Region: PRK14997 264730006767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730006768 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264730006769 putative effector binding pocket; other site 264730006770 dimerization interface [polypeptide binding]; other site 264730006771 Protein of unknown function (DUF330); Region: DUF330; pfam03886 264730006772 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 264730006773 mce related protein; Region: MCE; pfam02470 264730006774 mce related protein; Region: MCE; pfam02470 264730006775 mce related protein; Region: MCE; pfam02470 264730006776 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 264730006777 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 264730006778 active site 264730006779 Zn binding site [ion binding]; other site 264730006780 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 264730006781 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264730006782 putative efflux protein, MATE family; Region: matE; TIGR00797 264730006783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730006784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730006785 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264730006786 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264730006787 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 264730006788 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264730006789 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 264730006790 Water Stress and Hypersensitive response; Region: WHy; smart00769 264730006791 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 264730006792 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264730006793 dimer interface [polypeptide binding]; other site 264730006794 active site 264730006795 enoyl-CoA hydratase; Provisional; Region: PRK05862 264730006796 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264730006797 substrate binding site [chemical binding]; other site 264730006798 oxyanion hole (OAH) forming residues; other site 264730006799 trimer interface [polypeptide binding]; other site 264730006800 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 264730006801 hypothetical protein; Provisional; Region: PRK12378 264730006802 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264730006803 Leucine rich repeat; Region: LRR_8; pfam13855 264730006804 Leucine rich repeat; Region: LRR_8; pfam13855 264730006805 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 264730006806 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264730006807 active site 264730006808 ATP binding site [chemical binding]; other site 264730006809 substrate binding site [chemical binding]; other site 264730006810 activation loop (A-loop); other site 264730006811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730006812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730006813 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264730006814 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 264730006815 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 264730006816 active site 264730006817 Zn binding site [ion binding]; other site 264730006818 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264730006819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730006820 putative DNA binding site [nucleotide binding]; other site 264730006821 putative Zn2+ binding site [ion binding]; other site 264730006822 AsnC family; Region: AsnC_trans_reg; pfam01037 264730006823 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 264730006824 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264730006825 dimer interface [polypeptide binding]; other site 264730006826 PYR/PP interface [polypeptide binding]; other site 264730006827 TPP binding site [chemical binding]; other site 264730006828 substrate binding site [chemical binding]; other site 264730006829 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 264730006830 TPP-binding site; other site 264730006831 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 264730006832 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 264730006833 active site 264730006834 SAM binding site [chemical binding]; other site 264730006835 homodimer interface [polypeptide binding]; other site 264730006836 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 264730006837 Predicted integral membrane protein [Function unknown]; Region: COG5446 264730006838 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 264730006839 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 264730006840 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 264730006841 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 264730006842 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 264730006843 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 264730006844 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 264730006845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730006846 Walker A motif; other site 264730006847 ATP binding site [chemical binding]; other site 264730006848 Walker B motif; other site 264730006849 arginine finger; other site 264730006850 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264730006851 metal ion-dependent adhesion site (MIDAS); other site 264730006852 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264730006853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730006854 Walker A motif; other site 264730006855 ATP binding site [chemical binding]; other site 264730006856 Walker B motif; other site 264730006857 arginine finger; other site 264730006858 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730006859 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 264730006860 AAA domain; Region: AAA_28; pfam13521 264730006861 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 264730006862 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 264730006863 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 264730006864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 264730006865 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 264730006866 LysR family transcriptional regulator; Provisional; Region: PRK14997 264730006867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730006868 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 264730006869 putative effector binding pocket; other site 264730006870 putative dimerization interface [polypeptide binding]; other site 264730006871 azoreductase; Reviewed; Region: PRK00170 264730006872 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264730006873 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264730006874 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264730006875 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730006876 active site 264730006877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730006878 S-adenosylmethionine binding site [chemical binding]; other site 264730006879 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 264730006880 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264730006881 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 264730006882 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 264730006883 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 264730006884 active site 264730006885 catalytic site [active] 264730006886 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 264730006887 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 264730006888 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 264730006889 active site 264730006890 catalytic site [active] 264730006891 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 264730006892 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 264730006893 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 264730006894 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 264730006895 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 264730006896 catalytic site [active] 264730006897 active site 264730006898 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 264730006899 glycogen synthase; Provisional; Region: glgA; PRK00654 264730006900 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 264730006901 ADP-binding pocket [chemical binding]; other site 264730006902 homodimer interface [polypeptide binding]; other site 264730006903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264730006904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730006905 Coenzyme A binding pocket [chemical binding]; other site 264730006906 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 264730006907 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264730006908 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 264730006909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730006910 active site 264730006911 motif I; other site 264730006912 motif II; other site 264730006913 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730006914 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 264730006915 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 264730006916 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 264730006917 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 264730006918 active site 264730006919 tetramer interface; other site 264730006920 glutathione reductase; Validated; Region: PRK06116 264730006921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730006922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264730006923 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264730006924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730006925 putative active site [active] 264730006926 PAS fold; Region: PAS_3; pfam08447 264730006927 heme pocket [chemical binding]; other site 264730006928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730006929 ATP binding site [chemical binding]; other site 264730006930 Mg2+ binding site [ion binding]; other site 264730006931 G-X-G motif; other site 264730006932 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 264730006933 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 264730006934 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 264730006935 DNA binding site [nucleotide binding] 264730006936 dimer interface [polypeptide binding]; other site 264730006937 active site 264730006938 Int/Topo IB signature motif; other site 264730006939 peroxiredoxin; Region: AhpC; TIGR03137 264730006940 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 264730006941 dimer interface [polypeptide binding]; other site 264730006942 decamer (pentamer of dimers) interface [polypeptide binding]; other site 264730006943 catalytic triad [active] 264730006944 peroxidatic and resolving cysteines [active] 264730006945 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 264730006946 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 264730006947 catalytic residue [active] 264730006948 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 264730006949 catalytic residues [active] 264730006950 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730006951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264730006952 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 264730006953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264730006954 dimer interface [polypeptide binding]; other site 264730006955 active site 264730006956 metal binding site [ion binding]; metal-binding site 264730006957 glutathione binding site [chemical binding]; other site 264730006958 HEAT repeats; Region: HEAT_2; pfam13646 264730006959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730006960 binding surface 264730006961 TPR motif; other site 264730006962 TPR repeat; Region: TPR_11; pfam13414 264730006963 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264730006964 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 264730006965 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264730006966 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730006967 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730006968 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730006969 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730006970 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730006971 dimerization interface [polypeptide binding]; other site 264730006972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730006973 dimer interface [polypeptide binding]; other site 264730006974 putative CheW interface [polypeptide binding]; other site 264730006975 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264730006976 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264730006977 Walker A/P-loop; other site 264730006978 ATP binding site [chemical binding]; other site 264730006979 Q-loop/lid; other site 264730006980 ABC transporter signature motif; other site 264730006981 Walker B; other site 264730006982 D-loop; other site 264730006983 H-loop/switch region; other site 264730006984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730006985 dimer interface [polypeptide binding]; other site 264730006986 conserved gate region; other site 264730006987 putative PBP binding loops; other site 264730006988 ABC-ATPase subunit interface; other site 264730006989 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730006990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730006991 dimer interface [polypeptide binding]; other site 264730006992 conserved gate region; other site 264730006993 putative PBP binding loops; other site 264730006994 ABC-ATPase subunit interface; other site 264730006995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730006996 substrate binding pocket [chemical binding]; other site 264730006997 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730006998 membrane-bound complex binding site; other site 264730006999 hinge residues; other site 264730007000 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 264730007001 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264730007002 Walker A/P-loop; other site 264730007003 ATP binding site [chemical binding]; other site 264730007004 Q-loop/lid; other site 264730007005 ABC transporter signature motif; other site 264730007006 Walker B; other site 264730007007 D-loop; other site 264730007008 H-loop/switch region; other site 264730007009 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264730007010 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730007011 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264730007012 TM-ABC transporter signature motif; other site 264730007013 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 264730007014 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 264730007015 PAAR motif; Region: PAAR_motif; pfam05488 264730007016 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 264730007017 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 264730007018 Transposase domain (DUF772); Region: DUF772; pfam05598 264730007019 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 264730007020 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264730007021 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730007022 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730007023 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 264730007024 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730007025 Walker A/P-loop; other site 264730007026 ATP binding site [chemical binding]; other site 264730007027 Q-loop/lid; other site 264730007028 ABC transporter signature motif; other site 264730007029 Walker B; other site 264730007030 D-loop; other site 264730007031 H-loop/switch region; other site 264730007032 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 264730007033 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730007034 Walker A/P-loop; other site 264730007035 ATP binding site [chemical binding]; other site 264730007036 Q-loop/lid; other site 264730007037 ABC transporter signature motif; other site 264730007038 Walker B; other site 264730007039 D-loop; other site 264730007040 H-loop/switch region; other site 264730007041 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730007042 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 264730007043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730007044 dimer interface [polypeptide binding]; other site 264730007045 conserved gate region; other site 264730007046 putative PBP binding loops; other site 264730007047 ABC-ATPase subunit interface; other site 264730007048 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264730007049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730007050 dimer interface [polypeptide binding]; other site 264730007051 conserved gate region; other site 264730007052 putative PBP binding loops; other site 264730007053 ABC-ATPase subunit interface; other site 264730007054 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264730007055 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 264730007056 D-serine deaminase transcriptional activator; Region: dsdC; TIGR02036 264730007057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007058 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264730007059 putative effector binding pocket; other site 264730007060 dimerization interface [polypeptide binding]; other site 264730007061 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 264730007062 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 264730007063 active site 264730007064 FMN binding site [chemical binding]; other site 264730007065 substrate binding site [chemical binding]; other site 264730007066 putative catalytic residue [active] 264730007067 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 264730007068 putative homodimer interface [polypeptide binding]; other site 264730007069 putative homotetramer interface [polypeptide binding]; other site 264730007070 putative metal binding site [ion binding]; other site 264730007071 putative homodimer-homodimer interface [polypeptide binding]; other site 264730007072 putative allosteric switch controlling residues; other site 264730007073 High-affinity nickel-transport protein; Region: NicO; cl00964 264730007074 High-affinity nickel-transport protein; Region: NicO; cl00964 264730007075 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 264730007076 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264730007077 putative metal binding site [ion binding]; other site 264730007078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730007079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007080 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 264730007081 putative dimerization interface [polypeptide binding]; other site 264730007082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730007083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007084 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 264730007085 putative substrate binding pocket [chemical binding]; other site 264730007086 dimerization interface [polypeptide binding]; other site 264730007087 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 264730007088 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 264730007089 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264730007090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730007091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730007092 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264730007093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730007094 putative substrate translocation pore; other site 264730007095 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730007096 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730007097 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730007098 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730007099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007100 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 264730007101 putative substrate binding pocket [chemical binding]; other site 264730007102 putative dimerization interface [polypeptide binding]; other site 264730007103 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 264730007104 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264730007105 putative NAD(P) binding site [chemical binding]; other site 264730007106 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730007107 MULE transposase domain; Region: MULE; pfam10551 264730007108 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 264730007109 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264730007110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730007111 DNA-binding site [nucleotide binding]; DNA binding site 264730007112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730007113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730007114 homodimer interface [polypeptide binding]; other site 264730007115 catalytic residue [active] 264730007116 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 264730007117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 264730007118 DEAD_2; Region: DEAD_2; pfam06733 264730007119 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 264730007120 phosphoglucomutase; Validated; Region: PRK07564 264730007121 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 264730007122 active site 264730007123 substrate binding site [chemical binding]; other site 264730007124 metal binding site [ion binding]; metal-binding site 264730007125 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 264730007126 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 264730007127 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264730007128 Walker A motif; other site 264730007129 ATP binding site [chemical binding]; other site 264730007130 Walker B motif; other site 264730007131 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 264730007132 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730007133 Walker A/P-loop; other site 264730007134 ATP binding site [chemical binding]; other site 264730007135 Q-loop/lid; other site 264730007136 ABC transporter signature motif; other site 264730007137 Walker B; other site 264730007138 D-loop; other site 264730007139 H-loop/switch region; other site 264730007140 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730007141 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730007142 Walker A/P-loop; other site 264730007143 ATP binding site [chemical binding]; other site 264730007144 Q-loop/lid; other site 264730007145 ABC transporter signature motif; other site 264730007146 Walker B; other site 264730007147 D-loop; other site 264730007148 H-loop/switch region; other site 264730007149 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730007150 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 264730007151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730007152 dimer interface [polypeptide binding]; other site 264730007153 conserved gate region; other site 264730007154 putative PBP binding loops; other site 264730007155 ABC-ATPase subunit interface; other site 264730007156 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 264730007157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730007158 dimer interface [polypeptide binding]; other site 264730007159 conserved gate region; other site 264730007160 putative PBP binding loops; other site 264730007161 ABC-ATPase subunit interface; other site 264730007162 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 264730007163 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 264730007164 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 264730007165 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 264730007166 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264730007167 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 264730007168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730007169 non-specific DNA binding site [nucleotide binding]; other site 264730007170 salt bridge; other site 264730007171 sequence-specific DNA binding site [nucleotide binding]; other site 264730007172 response regulator; Provisional; Region: PRK09483 264730007173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730007174 active site 264730007175 phosphorylation site [posttranslational modification] 264730007176 intermolecular recognition site; other site 264730007177 dimerization interface [polypeptide binding]; other site 264730007178 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730007179 DNA binding residues [nucleotide binding] 264730007180 dimerization interface [polypeptide binding]; other site 264730007181 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 264730007182 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264730007183 GIY-YIG motif/motif A; other site 264730007184 active site 264730007185 catalytic site [active] 264730007186 putative DNA binding site [nucleotide binding]; other site 264730007187 metal binding site [ion binding]; metal-binding site 264730007188 UvrB/uvrC motif; Region: UVR; pfam02151 264730007189 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 264730007190 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 264730007191 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 264730007192 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 264730007193 putative ligand binding site [chemical binding]; other site 264730007194 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 264730007195 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 264730007196 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 264730007197 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 264730007198 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264730007199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730007200 Walker A motif; other site 264730007201 ATP binding site [chemical binding]; other site 264730007202 Walker B motif; other site 264730007203 arginine finger; other site 264730007204 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730007205 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264730007206 DNA binding site [nucleotide binding] 264730007207 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 264730007208 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 264730007209 putative ligand binding site [chemical binding]; other site 264730007210 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 264730007211 Fatty acid desaturase; Region: FA_desaturase; pfam00487 264730007212 putative di-iron ligands [ion binding]; other site 264730007213 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 264730007214 [2Fe-2S] cluster binding site [ion binding]; other site 264730007215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 264730007216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264730007217 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 264730007218 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 264730007219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730007220 dimer interface [polypeptide binding]; other site 264730007221 conserved gate region; other site 264730007222 putative PBP binding loops; other site 264730007223 ABC-ATPase subunit interface; other site 264730007224 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264730007225 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264730007226 Walker A/P-loop; other site 264730007227 ATP binding site [chemical binding]; other site 264730007228 Q-loop/lid; other site 264730007229 ABC transporter signature motif; other site 264730007230 Walker B; other site 264730007231 D-loop; other site 264730007232 H-loop/switch region; other site 264730007233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730007234 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 264730007235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264730007236 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 264730007237 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 264730007238 homotrimer interaction site [polypeptide binding]; other site 264730007239 putative active site [active] 264730007240 Tir chaperone protein (CesT) family; Region: CesT; cl08444 264730007241 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 264730007242 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264730007243 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730007244 TM-ABC transporter signature motif; other site 264730007245 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 264730007246 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264730007247 Walker A/P-loop; other site 264730007248 ATP binding site [chemical binding]; other site 264730007249 Q-loop/lid; other site 264730007250 ABC transporter signature motif; other site 264730007251 Walker B; other site 264730007252 D-loop; other site 264730007253 H-loop/switch region; other site 264730007254 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264730007255 xylose isomerase; Provisional; Region: PRK05474 264730007256 xylose isomerase; Region: xylose_isom_A; TIGR02630 264730007257 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 264730007258 putative dimerization interface [polypeptide binding]; other site 264730007259 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264730007260 putative ligand binding site [chemical binding]; other site 264730007261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264730007262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730007263 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 264730007264 active site 264730007265 VirK protein; Region: VirK; pfam06903 264730007266 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730007267 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730007268 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730007269 dimer interface [polypeptide binding]; other site 264730007270 putative CheW interface [polypeptide binding]; other site 264730007271 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 264730007272 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264730007273 putative ligand binding site [chemical binding]; other site 264730007274 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 264730007275 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264730007276 Walker A/P-loop; other site 264730007277 ATP binding site [chemical binding]; other site 264730007278 Q-loop/lid; other site 264730007279 ABC transporter signature motif; other site 264730007280 Walker B; other site 264730007281 D-loop; other site 264730007282 H-loop/switch region; other site 264730007283 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264730007284 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 264730007285 TM-ABC transporter signature motif; other site 264730007286 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264730007287 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730007288 TM-ABC transporter signature motif; other site 264730007289 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 264730007290 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 264730007291 Flavin binding site [chemical binding]; other site 264730007292 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264730007293 AMP-binding enzyme; Region: AMP-binding; pfam00501 264730007294 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264730007295 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264730007296 Walker A/P-loop; other site 264730007297 ATP binding site [chemical binding]; other site 264730007298 Q-loop/lid; other site 264730007299 ABC transporter signature motif; other site 264730007300 Walker B; other site 264730007301 D-loop; other site 264730007302 H-loop/switch region; other site 264730007303 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730007304 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264730007305 TM-ABC transporter signature motif; other site 264730007306 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264730007307 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264730007308 TM-ABC transporter signature motif; other site 264730007309 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 264730007310 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264730007311 putative ligand binding site [chemical binding]; other site 264730007312 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264730007313 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264730007314 Walker A/P-loop; other site 264730007315 ATP binding site [chemical binding]; other site 264730007316 Q-loop/lid; other site 264730007317 ABC transporter signature motif; other site 264730007318 Walker B; other site 264730007319 D-loop; other site 264730007320 H-loop/switch region; other site 264730007321 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 264730007322 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 264730007323 Flavin binding site [chemical binding]; other site 264730007324 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264730007325 active site 264730007326 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 264730007327 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 264730007328 active site 264730007329 non-prolyl cis peptide bond; other site 264730007330 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 264730007331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730007332 active site 264730007333 phosphorylation site [posttranslational modification] 264730007334 intermolecular recognition site; other site 264730007335 dimerization interface [polypeptide binding]; other site 264730007336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730007337 DNA binding site [nucleotide binding] 264730007338 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 264730007339 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730007340 dimerization interface [polypeptide binding]; other site 264730007341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730007342 dimer interface [polypeptide binding]; other site 264730007343 phosphorylation site [posttranslational modification] 264730007344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730007345 ATP binding site [chemical binding]; other site 264730007346 Mg2+ binding site [ion binding]; other site 264730007347 G-X-G motif; other site 264730007348 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264730007349 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730007350 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730007351 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264730007352 Protein export membrane protein; Region: SecD_SecF; cl14618 264730007353 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 264730007354 Tannase and feruloyl esterase; Region: Tannase; pfam07519 264730007355 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 264730007356 Isochorismatase family; Region: Isochorismatase; pfam00857 264730007357 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 264730007358 catalytic triad [active] 264730007359 conserved cis-peptide bond; other site 264730007360 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 264730007361 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 264730007362 Predicted transcriptional regulator [Transcription]; Region: COG2932 264730007363 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264730007364 Catalytic site [active] 264730007365 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 264730007366 lysogenic prophage region; PHAGE04 264730007367 Predicted chitinase [General function prediction only]; Region: COG3179 264730007368 catalytic residue [active] 264730007369 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 264730007370 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 264730007371 active site 264730007372 catalytic triad [active] 264730007373 oxyanion hole [active] 264730007374 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 264730007375 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 264730007376 active site 264730007377 DNA binding site [nucleotide binding] 264730007378 Int/Topo IB signature motif; other site 264730007379 catalytic residues [active] 264730007380 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 264730007381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730007382 Walker A/P-loop; other site 264730007383 ATP binding site [chemical binding]; other site 264730007384 Q-loop/lid; other site 264730007385 ABC transporter signature motif; other site 264730007386 Walker B; other site 264730007387 D-loop; other site 264730007388 H-loop/switch region; other site 264730007389 TOBE domain; Region: TOBE; cl01440 264730007390 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 264730007391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730007392 dimer interface [polypeptide binding]; other site 264730007393 conserved gate region; other site 264730007394 putative PBP binding loops; other site 264730007395 ABC-ATPase subunit interface; other site 264730007396 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 264730007397 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264730007398 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264730007399 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264730007400 FMN binding site [chemical binding]; other site 264730007401 substrate binding site [chemical binding]; other site 264730007402 putative catalytic residue [active] 264730007403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730007404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730007405 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 264730007406 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 264730007407 NADP binding site [chemical binding]; other site 264730007408 dimer interface [polypeptide binding]; other site 264730007409 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 264730007410 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 264730007411 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730007412 active site 264730007413 DNA binding site [nucleotide binding] 264730007414 Int/Topo IB signature motif; other site 264730007415 Cupin domain; Region: Cupin_2; pfam07883 264730007416 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 264730007417 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264730007418 active site 264730007419 nucleotide binding site [chemical binding]; other site 264730007420 HIGH motif; other site 264730007421 KMSKS motif; other site 264730007422 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264730007423 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 264730007424 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264730007425 ligand binding site [chemical binding]; other site 264730007426 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 264730007427 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730007428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730007429 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 264730007430 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264730007431 dimer interface [polypeptide binding]; other site 264730007432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730007433 catalytic residue [active] 264730007434 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 264730007435 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 264730007436 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 264730007437 LysE type translocator; Region: LysE; cl00565 264730007438 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264730007439 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 264730007440 putative active site [active] 264730007441 metal binding site [ion binding]; metal-binding site 264730007442 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264730007443 Beta-lactamase; Region: Beta-lactamase; pfam00144 264730007444 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 264730007445 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264730007446 conserved cys residue [active] 264730007447 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730007448 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 264730007449 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 264730007450 conserved cys residue [active] 264730007451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730007452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730007454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264730007455 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 264730007456 Activator of aromatic catabolism; Region: XylR_N; pfam06505 264730007457 V4R domain; Region: V4R; pfam02830 264730007458 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 264730007459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730007460 Walker A motif; other site 264730007461 ATP binding site [chemical binding]; other site 264730007462 Walker B motif; other site 264730007463 arginine finger; other site 264730007464 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264730007465 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 264730007466 NAD(P) binding site [chemical binding]; other site 264730007467 catalytic residues [active] 264730007468 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 264730007469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730007470 NAD(P) binding site [chemical binding]; other site 264730007471 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 264730007472 active site 264730007473 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 264730007474 benzoate transport; Region: 2A0115; TIGR00895 264730007475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730007476 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264730007477 MarR family; Region: MarR_2; pfam12802 264730007478 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 264730007479 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264730007480 substrate binding site [chemical binding]; other site 264730007481 oxyanion hole (OAH) forming residues; other site 264730007482 trimer interface [polypeptide binding]; other site 264730007483 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264730007484 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 264730007485 NAD(P) binding site [chemical binding]; other site 264730007486 catalytic residues [active] 264730007487 feruloyl-CoA synthase; Reviewed; Region: PRK08180 264730007488 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 264730007489 acyl-activating enzyme (AAE) consensus motif; other site 264730007490 putative AMP binding site [chemical binding]; other site 264730007491 putative active site [active] 264730007492 putative CoA binding site [chemical binding]; other site 264730007493 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264730007494 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 264730007495 dimer interface [polypeptide binding]; other site 264730007496 active site 264730007497 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 264730007498 homotrimer interaction site [polypeptide binding]; other site 264730007499 putative active site [active] 264730007500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730007501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007502 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 264730007503 putative effector binding pocket; other site 264730007504 putative dimerization interface [polypeptide binding]; other site 264730007505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730007506 Walker A/P-loop; other site 264730007507 ATP binding site [chemical binding]; other site 264730007508 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730007509 MULE transposase domain; Region: MULE; pfam10551 264730007510 AAA domain; Region: AAA_21; pfam13304 264730007511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730007512 ABC transporter signature motif; other site 264730007513 Walker B; other site 264730007514 D-loop; other site 264730007515 H-loop/switch region; other site 264730007516 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 264730007517 putative active site [active] 264730007518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730007519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007520 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 264730007521 putative substrate binding pocket [chemical binding]; other site 264730007522 dimerization interface [polypeptide binding]; other site 264730007523 hypothetical protein; Provisional; Region: PRK12569 264730007524 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 264730007525 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 264730007526 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 264730007527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730007528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730007529 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730007530 MULE transposase domain; Region: MULE; pfam10551 264730007531 outer membrane porin, OprD family; Region: OprD; pfam03573 264730007532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730007533 putative substrate translocation pore; other site 264730007534 aspartate aminotransferase; Provisional; Region: PRK06107 264730007535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730007536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730007537 homodimer interface [polypeptide binding]; other site 264730007538 catalytic residue [active] 264730007539 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 264730007540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007541 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264730007542 putative dimerization interface [polypeptide binding]; other site 264730007543 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264730007544 carboxyltransferase (CT) interaction site; other site 264730007545 biotinylation site [posttranslational modification]; other site 264730007546 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 264730007547 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264730007548 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 264730007549 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264730007550 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 264730007551 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 264730007552 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 264730007553 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 264730007554 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264730007555 carboxyltransferase (CT) interaction site; other site 264730007556 biotinylation site [posttranslational modification]; other site 264730007557 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 264730007558 putative active site [active] 264730007559 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 264730007560 classical (c) SDRs; Region: SDR_c; cd05233 264730007561 NAD(P) binding site [chemical binding]; other site 264730007562 active site 264730007563 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730007564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730007565 dimer interface [polypeptide binding]; other site 264730007566 conserved gate region; other site 264730007567 putative PBP binding loops; other site 264730007568 ABC-ATPase subunit interface; other site 264730007569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730007570 dimer interface [polypeptide binding]; other site 264730007571 conserved gate region; other site 264730007572 putative PBP binding loops; other site 264730007573 ABC-ATPase subunit interface; other site 264730007574 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264730007575 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264730007576 Walker A/P-loop; other site 264730007577 ATP binding site [chemical binding]; other site 264730007578 Q-loop/lid; other site 264730007579 ABC transporter signature motif; other site 264730007580 Walker B; other site 264730007581 D-loop; other site 264730007582 H-loop/switch region; other site 264730007583 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730007584 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730007585 substrate binding pocket [chemical binding]; other site 264730007586 membrane-bound complex binding site; other site 264730007587 hinge residues; other site 264730007588 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 264730007589 mce related protein; Region: MCE; pfam02470 264730007590 mce related protein; Region: MCE; pfam02470 264730007591 mce related protein; Region: MCE; pfam02470 264730007592 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 264730007593 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 264730007594 active site 264730007595 tetramer interface [polypeptide binding]; other site 264730007596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730007597 D-galactonate transporter; Region: 2A0114; TIGR00893 264730007598 putative substrate translocation pore; other site 264730007599 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264730007600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007601 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 264730007602 putative dimerization interface [polypeptide binding]; other site 264730007603 putative substrate binding pocket [chemical binding]; other site 264730007604 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 264730007605 active site 264730007606 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 264730007607 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730007608 metal binding site [ion binding]; metal-binding site 264730007609 active site 264730007610 I-site; other site 264730007611 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730007612 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730007613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730007614 DNA-binding site [nucleotide binding]; DNA binding site 264730007615 FCD domain; Region: FCD; pfam07729 264730007616 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264730007617 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264730007618 FMN-binding pocket [chemical binding]; other site 264730007619 flavin binding motif; other site 264730007620 phosphate binding motif [ion binding]; other site 264730007621 beta-alpha-beta structure motif; other site 264730007622 NAD binding pocket [chemical binding]; other site 264730007623 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 264730007624 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264730007625 catalytic loop [active] 264730007626 iron binding site [ion binding]; other site 264730007627 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264730007628 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264730007629 iron-sulfur cluster [ion binding]; other site 264730007630 [2Fe-2S] cluster binding site [ion binding]; other site 264730007631 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 264730007632 alpha subunit interface [polypeptide binding]; other site 264730007633 active site 264730007634 substrate binding site [chemical binding]; other site 264730007635 Fe binding site [ion binding]; other site 264730007636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730007637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007638 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730007639 dimerization interface [polypeptide binding]; other site 264730007640 Peptidase C26; Region: Peptidase_C26; pfam07722 264730007641 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 264730007642 catalytic triad [active] 264730007643 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 264730007644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730007645 non-specific DNA binding site [nucleotide binding]; other site 264730007646 salt bridge; other site 264730007647 sequence-specific DNA binding site [nucleotide binding]; other site 264730007648 Cupin domain; Region: Cupin_2; pfam07883 264730007649 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 264730007650 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 264730007651 NAD binding site [chemical binding]; other site 264730007652 homodimer interface [polypeptide binding]; other site 264730007653 active site 264730007654 substrate binding site [chemical binding]; other site 264730007655 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 264730007656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730007657 putative homodimer interface [polypeptide binding]; other site 264730007658 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 264730007659 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264730007660 UDP-galactopyranose mutase; Region: GLF; pfam03275 264730007661 histidine kinase; Provisional; Region: PRK13557 264730007662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730007663 putative active site [active] 264730007664 heme pocket [chemical binding]; other site 264730007665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730007666 dimer interface [polypeptide binding]; other site 264730007667 phosphorylation site [posttranslational modification] 264730007668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730007669 ATP binding site [chemical binding]; other site 264730007670 Mg2+ binding site [ion binding]; other site 264730007671 G-X-G motif; other site 264730007672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730007673 active site 264730007674 phosphorylation site [posttranslational modification] 264730007675 intermolecular recognition site; other site 264730007676 dimerization interface [polypeptide binding]; other site 264730007677 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730007678 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730007679 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730007680 putative acetyltransferase YhhY; Provisional; Region: PRK10140 264730007681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730007682 Coenzyme A binding pocket [chemical binding]; other site 264730007683 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 264730007684 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264730007685 active site 264730007686 iron coordination sites [ion binding]; other site 264730007687 substrate binding pocket [chemical binding]; other site 264730007688 BRO family, N-terminal domain; Region: Bro-N; smart01040 264730007689 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 264730007690 GAF domain; Region: GAF; pfam01590 264730007691 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730007692 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730007693 dimerization interface [polypeptide binding]; other site 264730007694 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730007695 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730007696 dimer interface [polypeptide binding]; other site 264730007697 putative CheW interface [polypeptide binding]; other site 264730007698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730007699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007700 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 264730007701 putative effector binding pocket; other site 264730007702 putative dimerization interface [polypeptide binding]; other site 264730007703 acetylornithine aminotransferase; Provisional; Region: PRK02627 264730007704 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730007705 inhibitor-cofactor binding pocket; inhibition site 264730007706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730007707 catalytic residue [active] 264730007708 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 264730007709 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 264730007710 FOG: CBS domain [General function prediction only]; Region: COG0517 264730007711 DNA polymerase II; Reviewed; Region: PRK05762 264730007712 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 264730007713 active site 264730007714 catalytic site [active] 264730007715 substrate binding site [chemical binding]; other site 264730007716 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 264730007717 active site 264730007718 metal-binding site 264730007719 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 264730007720 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 264730007721 NAD+ binding site [chemical binding]; other site 264730007722 substrate binding site [chemical binding]; other site 264730007723 Zn binding site [ion binding]; other site 264730007724 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 264730007725 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 264730007726 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 264730007727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730007728 FeS/SAM binding site; other site 264730007729 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 264730007730 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 264730007731 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 264730007732 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264730007733 ABC-ATPase subunit interface; other site 264730007734 dimer interface [polypeptide binding]; other site 264730007735 putative PBP binding regions; other site 264730007736 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 264730007737 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 264730007738 metal binding site [ion binding]; metal-binding site 264730007739 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 264730007740 active site 264730007741 catalytic residues [active] 264730007742 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 264730007743 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 264730007744 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 264730007745 ligand binding site [chemical binding]; other site 264730007746 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 264730007747 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264730007748 Walker A/P-loop; other site 264730007749 ATP binding site [chemical binding]; other site 264730007750 Q-loop/lid; other site 264730007751 ABC transporter signature motif; other site 264730007752 Walker B; other site 264730007753 D-loop; other site 264730007754 H-loop/switch region; other site 264730007755 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264730007756 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264730007757 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730007758 TM-ABC transporter signature motif; other site 264730007759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730007760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730007761 dimer interface [polypeptide binding]; other site 264730007762 phosphorylation site [posttranslational modification] 264730007763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730007764 ATP binding site [chemical binding]; other site 264730007765 Mg2+ binding site [ion binding]; other site 264730007766 G-X-G motif; other site 264730007767 amino acid transporter; Region: 2A0306; TIGR00909 264730007768 Spore germination protein; Region: Spore_permease; cl17796 264730007769 Primase helical domain; Region: pRN1_helical; pfam13010 264730007770 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 264730007771 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 264730007772 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 264730007773 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 264730007774 TPR repeat; Region: TPR_11; pfam13414 264730007775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730007776 binding surface 264730007777 TPR motif; other site 264730007778 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 264730007779 FHIPEP family; Region: FHIPEP; pfam00771 264730007780 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 264730007781 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 264730007782 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264730007783 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264730007784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730007785 binding surface 264730007786 TPR motif; other site 264730007787 TPR repeat; Region: TPR_11; pfam13414 264730007788 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 264730007789 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 264730007790 Nodulation protein NolV; Region: NolV; pfam06635 264730007791 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 264730007792 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264730007793 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264730007794 Walker A motif; other site 264730007795 ATP binding site [chemical binding]; other site 264730007796 Walker B motif; other site 264730007797 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730007798 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730007799 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730007800 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 264730007801 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 264730007802 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 264730007803 type III secretion system protein YscR; Provisional; Region: PRK12797 264730007804 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 264730007805 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 264730007806 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 264730007807 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264730007808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730007809 DNA binding site [nucleotide binding] 264730007810 Predicted ATPase [General function prediction only]; Region: COG3903 264730007811 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730007812 MULE transposase domain; Region: MULE; pfam10551 264730007813 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 264730007814 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 264730007815 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 264730007816 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 264730007817 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 264730007818 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730007819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 264730007820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730007821 active site 264730007822 phosphorylation site [posttranslational modification] 264730007823 intermolecular recognition site; other site 264730007824 dimerization interface [polypeptide binding]; other site 264730007825 malate:quinone oxidoreductase; Validated; Region: PRK05257 264730007826 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 264730007827 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264730007828 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264730007829 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264730007830 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 264730007831 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264730007832 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264730007833 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264730007834 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 264730007835 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264730007836 XdhC Rossmann domain; Region: XdhC_C; pfam13478 264730007837 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 264730007838 Ligand binding site; other site 264730007839 metal-binding site 264730007840 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 264730007841 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 264730007842 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 264730007843 NAD(P) binding site [chemical binding]; other site 264730007844 catalytic residues [active] 264730007845 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730007846 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007847 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 264730007848 putative dimerization interface [polypeptide binding]; other site 264730007849 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 264730007850 tartrate dehydrogenase; Region: TTC; TIGR02089 264730007851 transcriptional activator TtdR; Provisional; Region: PRK09801 264730007852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007853 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 264730007854 putative effector binding pocket; other site 264730007855 putative dimerization interface [polypeptide binding]; other site 264730007856 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 264730007857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730007858 Walker A/P-loop; other site 264730007859 ATP binding site [chemical binding]; other site 264730007860 Q-loop/lid; other site 264730007861 ABC transporter signature motif; other site 264730007862 Walker B; other site 264730007863 D-loop; other site 264730007864 H-loop/switch region; other site 264730007865 TOBE domain; Region: TOBE_2; pfam08402 264730007866 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264730007867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730007868 dimer interface [polypeptide binding]; other site 264730007869 conserved gate region; other site 264730007870 putative PBP binding loops; other site 264730007871 ABC-ATPase subunit interface; other site 264730007872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730007873 dimer interface [polypeptide binding]; other site 264730007874 conserved gate region; other site 264730007875 putative PBP binding loops; other site 264730007876 ABC-ATPase subunit interface; other site 264730007877 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 264730007878 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 264730007879 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485 264730007880 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 264730007881 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 264730007882 dimerization interface [polypeptide binding]; other site 264730007883 active site 264730007884 Uncharacterized conserved protein [Function unknown]; Region: COG5470 264730007885 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 264730007886 nudix motif; other site 264730007887 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264730007888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730007889 DNA-binding site [nucleotide binding]; DNA binding site 264730007890 FCD domain; Region: FCD; pfam07729 264730007891 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 264730007892 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264730007893 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 264730007894 NAD(P) binding site [chemical binding]; other site 264730007895 catalytic residues [active] 264730007896 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 264730007897 Amino acid synthesis; Region: AA_synth; pfam06684 264730007898 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730007899 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730007900 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730007901 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 264730007902 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 264730007903 NAD binding site [chemical binding]; other site 264730007904 catalytic Zn binding site [ion binding]; other site 264730007905 structural Zn binding site [ion binding]; other site 264730007906 short chain dehydrogenase; Provisional; Region: PRK06701 264730007907 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 264730007908 NAD binding site [chemical binding]; other site 264730007909 metal binding site [ion binding]; metal-binding site 264730007910 active site 264730007911 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264730007912 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730007913 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264730007914 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264730007915 tetramerization interface [polypeptide binding]; other site 264730007916 NAD(P) binding site [chemical binding]; other site 264730007917 catalytic residues [active] 264730007918 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 264730007919 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 264730007920 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 264730007921 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264730007922 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264730007923 shikimate binding site; other site 264730007924 NAD(P) binding site [chemical binding]; other site 264730007925 Protein of unknown function, DUF480; Region: DUF480; pfam04337 264730007926 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 264730007927 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264730007928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730007929 putative substrate translocation pore; other site 264730007930 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 264730007931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730007932 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 264730007933 putative dimerization interface [polypeptide binding]; other site 264730007934 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 264730007935 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 264730007936 putative active site [active] 264730007937 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264730007938 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264730007939 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 264730007940 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264730007941 NAD(P) binding site [chemical binding]; other site 264730007942 active site 264730007943 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 264730007944 nudix motif; other site 264730007945 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 264730007946 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 264730007947 putative NAD(P) binding site [chemical binding]; other site 264730007948 putative substrate binding site [chemical binding]; other site 264730007949 catalytic Zn binding site [ion binding]; other site 264730007950 structural Zn binding site [ion binding]; other site 264730007951 dimer interface [polypeptide binding]; other site 264730007952 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 264730007953 GAF domain; Region: GAF_3; pfam13492 264730007954 GAF domain; Region: GAF_2; pfam13185 264730007955 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730007956 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730007957 metal binding site [ion binding]; metal-binding site 264730007958 active site 264730007959 I-site; other site 264730007960 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730007961 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264730007962 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 264730007963 putative substrate binding site [chemical binding]; other site 264730007964 putative ATP binding site [chemical binding]; other site 264730007965 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 264730007966 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 264730007967 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 264730007968 D-xylulose kinase; Region: XylB; TIGR01312 264730007969 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 264730007970 N- and C-terminal domain interface [polypeptide binding]; other site 264730007971 active site 264730007972 MgATP binding site [chemical binding]; other site 264730007973 catalytic site [active] 264730007974 metal binding site [ion binding]; metal-binding site 264730007975 xylulose binding site [chemical binding]; other site 264730007976 putative homodimer interface [polypeptide binding]; other site 264730007977 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 264730007978 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 264730007979 Walker A/P-loop; other site 264730007980 ATP binding site [chemical binding]; other site 264730007981 Q-loop/lid; other site 264730007982 ABC transporter signature motif; other site 264730007983 Walker B; other site 264730007984 D-loop; other site 264730007985 H-loop/switch region; other site 264730007986 TOBE domain; Region: TOBE_2; pfam08402 264730007987 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 264730007988 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264730007989 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 264730007990 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 264730007991 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264730007992 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264730007993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730007994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730007995 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 264730007996 active site 264730007997 SAM binding site [chemical binding]; other site 264730007998 homodimer interface [polypeptide binding]; other site 264730007999 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 264730008000 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264730008001 Response regulator receiver domain; Region: Response_reg; pfam00072 264730008002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730008003 active site 264730008004 phosphorylation site [posttranslational modification] 264730008005 intermolecular recognition site; other site 264730008006 dimerization interface [polypeptide binding]; other site 264730008007 CHASE3 domain; Region: CHASE3; pfam05227 264730008008 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 264730008009 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 264730008010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730008011 dimer interface [polypeptide binding]; other site 264730008012 phosphorylation site [posttranslational modification] 264730008013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730008014 ATP binding site [chemical binding]; other site 264730008015 Mg2+ binding site [ion binding]; other site 264730008016 G-X-G motif; other site 264730008017 Response regulator receiver domain; Region: Response_reg; pfam00072 264730008018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730008019 active site 264730008020 phosphorylation site [posttranslational modification] 264730008021 intermolecular recognition site; other site 264730008022 dimerization interface [polypeptide binding]; other site 264730008023 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730008024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730008025 active site 264730008026 phosphorylation site [posttranslational modification] 264730008027 intermolecular recognition site; other site 264730008028 Response regulator receiver domain; Region: Response_reg; pfam00072 264730008029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730008030 active site 264730008031 phosphorylation site [posttranslational modification] 264730008032 intermolecular recognition site; other site 264730008033 dimerization interface [polypeptide binding]; other site 264730008034 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264730008035 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 264730008036 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 264730008037 CheB methylesterase; Region: CheB_methylest; pfam01339 264730008038 Response regulator receiver domain; Region: Response_reg; pfam00072 264730008039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730008040 active site 264730008041 phosphorylation site [posttranslational modification] 264730008042 intermolecular recognition site; other site 264730008043 dimerization interface [polypeptide binding]; other site 264730008044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 264730008045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730008046 dimer interface [polypeptide binding]; other site 264730008047 phosphorylation site [posttranslational modification] 264730008048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730008049 ATP binding site [chemical binding]; other site 264730008050 Mg2+ binding site [ion binding]; other site 264730008051 G-X-G motif; other site 264730008052 Response regulator receiver domain; Region: Response_reg; pfam00072 264730008053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730008054 active site 264730008055 phosphorylation site [posttranslational modification] 264730008056 intermolecular recognition site; other site 264730008057 dimerization interface [polypeptide binding]; other site 264730008058 PAS fold; Region: PAS_3; pfam08447 264730008059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730008060 putative active site [active] 264730008061 heme pocket [chemical binding]; other site 264730008062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730008063 dimer interface [polypeptide binding]; other site 264730008064 phosphorylation site [posttranslational modification] 264730008065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730008066 ATP binding site [chemical binding]; other site 264730008067 Mg2+ binding site [ion binding]; other site 264730008068 G-X-G motif; other site 264730008069 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730008070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730008071 active site 264730008072 phosphorylation site [posttranslational modification] 264730008073 intermolecular recognition site; other site 264730008074 dimerization interface [polypeptide binding]; other site 264730008075 circadian clock protein KaiC; Reviewed; Region: PRK09302 264730008076 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264730008077 Walker A motif; other site 264730008078 ATP binding site [chemical binding]; other site 264730008079 Walker B motif; other site 264730008080 recA bacterial DNA recombination protein; Region: RecA; cl17211 264730008081 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264730008082 Walker A motif; other site 264730008083 ATP binding site [chemical binding]; other site 264730008084 Walker B motif; other site 264730008085 enoyl-CoA hydratase; Provisional; Region: PRK06142 264730008086 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264730008087 substrate binding site [chemical binding]; other site 264730008088 oxyanion hole (OAH) forming residues; other site 264730008089 trimer interface [polypeptide binding]; other site 264730008090 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 264730008091 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 264730008092 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 264730008093 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 264730008094 putative NADH binding site [chemical binding]; other site 264730008095 putative active site [active] 264730008096 nudix motif; other site 264730008097 putative metal binding site [ion binding]; other site 264730008098 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264730008099 hypothetical protein; Provisional; Region: PRK10621 264730008100 short chain dehydrogenase; Provisional; Region: PRK07035 264730008101 classical (c) SDRs; Region: SDR_c; cd05233 264730008102 NAD(P) binding site [chemical binding]; other site 264730008103 active site 264730008104 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264730008105 Phosphotransferase enzyme family; Region: APH; pfam01636 264730008106 putative active site [active] 264730008107 putative substrate binding site [chemical binding]; other site 264730008108 ATP binding site [chemical binding]; other site 264730008109 SCP-2 sterol transfer family; Region: SCP2; pfam02036 264730008110 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264730008111 catalytic core [active] 264730008112 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 264730008113 putative inner membrane peptidase; Provisional; Region: PRK11778 264730008114 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 264730008115 tandem repeat interface [polypeptide binding]; other site 264730008116 oligomer interface [polypeptide binding]; other site 264730008117 active site residues [active] 264730008118 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 264730008119 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 264730008120 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264730008121 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264730008122 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324 264730008123 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264730008124 putative ligand binding site [chemical binding]; other site 264730008125 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 264730008126 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 264730008127 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 264730008128 substrate binding pocket [chemical binding]; other site 264730008129 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 264730008130 B12 binding site [chemical binding]; other site 264730008131 cobalt ligand [ion binding]; other site 264730008132 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 264730008133 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 264730008134 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 264730008135 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 264730008136 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 264730008137 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 264730008138 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 264730008139 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264730008140 substrate binding site [chemical binding]; other site 264730008141 oxyanion hole (OAH) forming residues; other site 264730008142 trimer interface [polypeptide binding]; other site 264730008143 Spt5 C-terminal nonapeptide repeat binding Spt4; Region: CTD; cl17750 264730008144 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 264730008145 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 264730008146 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264730008147 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 264730008148 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 264730008149 active site 264730008150 catalytic residues [active] 264730008151 metal binding site [ion binding]; metal-binding site 264730008152 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 264730008153 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 264730008154 DNA binding residues [nucleotide binding] 264730008155 putative dimer interface [polypeptide binding]; other site 264730008156 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 264730008157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730008158 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 264730008159 substrate binding pocket [chemical binding]; other site 264730008160 dimerization interface [polypeptide binding]; other site 264730008161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264730008162 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 264730008163 FAD binding site [chemical binding]; other site 264730008164 substrate binding site [chemical binding]; other site 264730008165 catalytic base [active] 264730008166 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 264730008167 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264730008168 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264730008169 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730008170 ligand binding site [chemical binding]; other site 264730008171 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 264730008172 putative catalytic site [active] 264730008173 putative phosphate binding site [ion binding]; other site 264730008174 active site 264730008175 metal binding site A [ion binding]; metal-binding site 264730008176 DNA binding site [nucleotide binding] 264730008177 putative AP binding site [nucleotide binding]; other site 264730008178 putative metal binding site B [ion binding]; other site 264730008179 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 264730008180 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 264730008181 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264730008182 Surface antigen; Region: Bac_surface_Ag; pfam01103 264730008183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 264730008184 Family of unknown function (DUF490); Region: DUF490; pfam04357 264730008185 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730008186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730008187 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 264730008188 putative effector binding pocket; other site 264730008189 putative dimerization interface [polypeptide binding]; other site 264730008190 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 264730008191 dimer interface [polypeptide binding]; other site 264730008192 catalytic triad [active] 264730008193 peroxidatic and resolving cysteines [active] 264730008194 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 264730008195 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730008196 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730008197 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 264730008198 Protein export membrane protein; Region: SecD_SecF; cl14618 264730008199 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 264730008200 Protein export membrane protein; Region: SecD_SecF; cl14618 264730008201 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264730008202 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 264730008203 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 264730008204 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 264730008205 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730008206 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730008207 metal binding site [ion binding]; metal-binding site 264730008208 active site 264730008209 I-site; other site 264730008210 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730008211 short chain dehydrogenase; Provisional; Region: PRK06123 264730008212 classical (c) SDRs; Region: SDR_c; cd05233 264730008213 NAD(P) binding site [chemical binding]; other site 264730008214 active site 264730008215 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 264730008216 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 264730008217 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 264730008218 active site 264730008219 homodimer interface [polypeptide binding]; other site 264730008220 catalytic site [active] 264730008221 acceptor binding site [chemical binding]; other site 264730008222 trehalose synthase; Region: treS_nterm; TIGR02456 264730008223 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 264730008224 active site 264730008225 catalytic site [active] 264730008226 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 264730008227 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 264730008228 glycogen branching enzyme; Provisional; Region: PRK05402 264730008229 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 264730008230 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 264730008231 active site 264730008232 catalytic site [active] 264730008233 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 264730008234 major facilitator superfamily transporter; Provisional; Region: PRK05122 264730008235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730008236 putative substrate translocation pore; other site 264730008237 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 264730008238 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 264730008239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730008240 Walker A/P-loop; other site 264730008241 ATP binding site [chemical binding]; other site 264730008242 Q-loop/lid; other site 264730008243 ABC transporter signature motif; other site 264730008244 Walker B; other site 264730008245 D-loop; other site 264730008246 H-loop/switch region; other site 264730008247 ABC transporter; Region: ABC_tran_2; pfam12848 264730008248 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264730008249 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 264730008250 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 264730008251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264730008252 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264730008253 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 264730008254 Hemerythrin-like domain; Region: Hr-like; cd12108 264730008255 Fe binding site [ion binding]; other site 264730008256 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730008257 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730008258 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730008259 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730008260 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730008261 substrate binding pocket [chemical binding]; other site 264730008262 membrane-bound complex binding site; other site 264730008263 hinge residues; other site 264730008264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008265 dimer interface [polypeptide binding]; other site 264730008266 conserved gate region; other site 264730008267 putative PBP binding loops; other site 264730008268 ABC-ATPase subunit interface; other site 264730008269 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730008270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008271 dimer interface [polypeptide binding]; other site 264730008272 conserved gate region; other site 264730008273 putative PBP binding loops; other site 264730008274 ABC-ATPase subunit interface; other site 264730008275 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264730008276 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264730008277 Walker A/P-loop; other site 264730008278 ATP binding site [chemical binding]; other site 264730008279 Q-loop/lid; other site 264730008280 ABC transporter signature motif; other site 264730008281 Walker B; other site 264730008282 D-loop; other site 264730008283 H-loop/switch region; other site 264730008284 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264730008285 homotrimer interaction site [polypeptide binding]; other site 264730008286 putative active site [active] 264730008287 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264730008288 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 264730008289 Bacterial transcriptional regulator; Region: IclR; pfam01614 264730008290 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 264730008291 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 264730008292 dimer interface [polypeptide binding]; other site 264730008293 active site 264730008294 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264730008295 substrate binding site [chemical binding]; other site 264730008296 catalytic residue [active] 264730008297 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264730008298 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 264730008299 substrate binding site [chemical binding]; other site 264730008300 ATP binding site [chemical binding]; other site 264730008301 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 264730008302 Family description; Region: UvrD_C_2; pfam13538 264730008303 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 264730008304 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 264730008305 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264730008306 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264730008307 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264730008308 Walker A/P-loop; other site 264730008309 ATP binding site [chemical binding]; other site 264730008310 Q-loop/lid; other site 264730008311 ABC transporter signature motif; other site 264730008312 Walker B; other site 264730008313 D-loop; other site 264730008314 H-loop/switch region; other site 264730008315 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264730008316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008317 dimer interface [polypeptide binding]; other site 264730008318 conserved gate region; other site 264730008319 putative PBP binding loops; other site 264730008320 ABC-ATPase subunit interface; other site 264730008321 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264730008322 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730008323 membrane-bound complex binding site; other site 264730008324 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264730008325 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264730008326 active site 264730008327 catalytic tetrad [active] 264730008328 LexA repressor; Provisional; Region: PRK12423 264730008329 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 264730008330 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264730008331 Catalytic site [active] 264730008332 Uncharacterized conserved protein [Function unknown]; Region: COG4544 264730008333 DNA Polymerase Y-family; Region: PolY_like; cd03468 264730008334 active site 264730008335 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 264730008336 DNA binding site [nucleotide binding] 264730008337 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 264730008338 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 264730008339 putative active site [active] 264730008340 putative PHP Thumb interface [polypeptide binding]; other site 264730008341 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264730008342 generic binding surface I; other site 264730008343 generic binding surface II; other site 264730008344 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 264730008345 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 264730008346 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 264730008347 oligomer interface [polypeptide binding]; other site 264730008348 Cl binding site [ion binding]; other site 264730008349 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 264730008350 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 264730008351 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264730008352 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264730008353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730008354 Coenzyme A binding pocket [chemical binding]; other site 264730008355 Peptidase_C39 like family; Region: DUF3335; pfam11814 264730008356 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 264730008357 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 264730008358 NodB motif; other site 264730008359 active site 264730008360 catalytic site [active] 264730008361 metal binding site [ion binding]; metal-binding site 264730008362 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 264730008363 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264730008364 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 264730008365 active site 264730008366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730008367 metabolite-proton symporter; Region: 2A0106; TIGR00883 264730008368 putative substrate translocation pore; other site 264730008369 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264730008370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730008371 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730008372 dimerization interface [polypeptide binding]; other site 264730008373 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264730008374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730008375 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730008376 dimerization interface [polypeptide binding]; other site 264730008377 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264730008378 FAD binding domain; Region: FAD_binding_4; pfam01565 264730008379 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264730008380 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264730008381 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264730008382 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730008383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730008384 metal binding site [ion binding]; metal-binding site 264730008385 active site 264730008386 I-site; other site 264730008387 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730008388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730008389 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730008390 dimerization interface [polypeptide binding]; other site 264730008391 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264730008392 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 264730008393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730008394 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264730008395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008396 dimer interface [polypeptide binding]; other site 264730008397 conserved gate region; other site 264730008398 putative PBP binding loops; other site 264730008399 ABC-ATPase subunit interface; other site 264730008400 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 264730008401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008402 dimer interface [polypeptide binding]; other site 264730008403 conserved gate region; other site 264730008404 putative PBP binding loops; other site 264730008405 ABC-ATPase subunit interface; other site 264730008406 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264730008407 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730008408 Walker A/P-loop; other site 264730008409 ATP binding site [chemical binding]; other site 264730008410 Q-loop/lid; other site 264730008411 ABC transporter signature motif; other site 264730008412 Walker B; other site 264730008413 D-loop; other site 264730008414 H-loop/switch region; other site 264730008415 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 264730008416 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 264730008417 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730008418 Walker A/P-loop; other site 264730008419 ATP binding site [chemical binding]; other site 264730008420 Q-loop/lid; other site 264730008421 ABC transporter signature motif; other site 264730008422 Walker B; other site 264730008423 D-loop; other site 264730008424 H-loop/switch region; other site 264730008425 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 264730008426 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 264730008427 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264730008428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 264730008429 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264730008430 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 264730008431 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 264730008432 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264730008433 active site 264730008434 metal binding site [ion binding]; metal-binding site 264730008435 hexamer interface [polypeptide binding]; other site 264730008436 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 264730008437 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 264730008438 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 264730008439 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264730008440 catalytic residue [active] 264730008441 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 264730008442 metal binding triad [ion binding]; metal-binding site 264730008443 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730008444 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 264730008445 inhibitor-cofactor binding pocket; inhibition site 264730008446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730008447 catalytic residue [active] 264730008448 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264730008449 hydrophobic ligand binding site; other site 264730008450 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264730008451 Male sterility protein; Region: NAD_binding_4; pfam07993 264730008452 NAD(P) binding site [chemical binding]; other site 264730008453 active site 264730008454 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 264730008455 Fatty acid desaturase; Region: FA_desaturase; pfam00487 264730008456 putative di-iron ligands [ion binding]; other site 264730008457 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 264730008458 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 264730008459 trimer interface [polypeptide binding]; other site 264730008460 active site 264730008461 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264730008462 trimer interface [polypeptide binding]; other site 264730008463 active site 264730008464 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264730008465 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 264730008466 AAA ATPase domain; Region: AAA_16; pfam13191 264730008467 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264730008468 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 264730008469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730008470 active site 264730008471 motif I; other site 264730008472 motif II; other site 264730008473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730008474 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264730008475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730008476 DNA-binding site [nucleotide binding]; DNA binding site 264730008477 FCD domain; Region: FCD; pfam07729 264730008478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730008479 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 264730008480 DAK2 domain; Region: Dak2; pfam02734 264730008481 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 264730008482 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 264730008483 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264730008484 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 264730008485 putative NAD(P) binding site [chemical binding]; other site 264730008486 catalytic Zn binding site [ion binding]; other site 264730008487 structural Zn binding site [ion binding]; other site 264730008488 short chain dehydrogenase; Provisional; Region: PRK06841 264730008489 classical (c) SDRs; Region: SDR_c; cd05233 264730008490 NAD(P) binding site [chemical binding]; other site 264730008491 active site 264730008492 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 264730008493 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264730008494 putative ligand binding site [chemical binding]; other site 264730008495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730008496 Walker B; other site 264730008497 D-loop; other site 264730008498 H-loop/switch region; other site 264730008499 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264730008500 ABC transporter; Region: ABC_tran; pfam00005 264730008501 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730008502 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264730008503 TM-ABC transporter signature motif; other site 264730008504 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730008505 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730008506 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730008507 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 264730008508 NAD(P) binding site [chemical binding]; other site 264730008509 catalytic residues [active] 264730008510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730008511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730008512 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 264730008513 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 264730008514 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 264730008515 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 264730008516 N- and C-terminal domain interface [polypeptide binding]; other site 264730008517 active site 264730008518 MgATP binding site [chemical binding]; other site 264730008519 catalytic site [active] 264730008520 metal binding site [ion binding]; metal-binding site 264730008521 xylulose binding site [chemical binding]; other site 264730008522 putative homodimer interface [polypeptide binding]; other site 264730008523 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 264730008524 intersubunit interface [polypeptide binding]; other site 264730008525 active site 264730008526 Zn2+ binding site [ion binding]; other site 264730008527 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730008528 L-lysine 6-transaminase; Region: LAT_fam; TIGR03251 264730008529 inhibitor-cofactor binding pocket; inhibition site 264730008530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730008531 catalytic residue [active] 264730008532 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 264730008533 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264730008534 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 264730008535 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264730008536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008537 putative PBP binding loops; other site 264730008538 dimer interface [polypeptide binding]; other site 264730008539 ABC-ATPase subunit interface; other site 264730008540 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 264730008541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008542 dimer interface [polypeptide binding]; other site 264730008543 conserved gate region; other site 264730008544 ABC-ATPase subunit interface; other site 264730008545 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 264730008546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730008547 Walker A/P-loop; other site 264730008548 ATP binding site [chemical binding]; other site 264730008549 Q-loop/lid; other site 264730008550 ABC transporter signature motif; other site 264730008551 Walker B; other site 264730008552 D-loop; other site 264730008553 H-loop/switch region; other site 264730008554 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 264730008555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730008556 Walker A/P-loop; other site 264730008557 ATP binding site [chemical binding]; other site 264730008558 Q-loop/lid; other site 264730008559 ABC transporter signature motif; other site 264730008560 Walker B; other site 264730008561 D-loop; other site 264730008562 H-loop/switch region; other site 264730008563 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 264730008564 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730008565 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730008566 DNA binding residues [nucleotide binding] 264730008567 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 264730008568 FecR protein; Region: FecR; pfam04773 264730008569 Secretin and TonB N terminus short domain; Region: STN; smart00965 264730008570 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264730008571 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730008572 N-terminal plug; other site 264730008573 ligand-binding site [chemical binding]; other site 264730008574 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 264730008575 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730008576 inhibitor-cofactor binding pocket; inhibition site 264730008577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730008578 catalytic residue [active] 264730008579 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 264730008580 IucA / IucC family; Region: IucA_IucC; pfam04183 264730008581 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 264730008582 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 264730008583 dimer interface [polypeptide binding]; other site 264730008584 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 264730008585 active site 264730008586 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264730008587 catalytic residues [active] 264730008588 substrate binding site [chemical binding]; other site 264730008589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730008590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730008591 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 264730008592 IucA / IucC family; Region: IucA_IucC; pfam04183 264730008593 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 264730008594 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 264730008595 IucA / IucC family; Region: IucA_IucC; pfam04183 264730008596 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 264730008597 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 264730008598 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 264730008599 siderophore binding site; other site 264730008600 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 264730008601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264730008602 ABC-ATPase subunit interface; other site 264730008603 dimer interface [polypeptide binding]; other site 264730008604 putative PBP binding regions; other site 264730008605 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 264730008606 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264730008607 ABC-ATPase subunit interface; other site 264730008608 dimer interface [polypeptide binding]; other site 264730008609 putative PBP binding regions; other site 264730008610 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 264730008611 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264730008612 Walker A/P-loop; other site 264730008613 ATP binding site [chemical binding]; other site 264730008614 Q-loop/lid; other site 264730008615 ABC transporter signature motif; other site 264730008616 Walker B; other site 264730008617 D-loop; other site 264730008618 H-loop/switch region; other site 264730008619 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 264730008620 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 264730008621 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 264730008622 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 264730008623 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 264730008624 nudix motif; other site 264730008625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730008626 PAS domain; Region: PAS_9; pfam13426 264730008627 putative active site [active] 264730008628 heme pocket [chemical binding]; other site 264730008629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730008630 PAS domain; Region: PAS_9; pfam13426 264730008631 putative active site [active] 264730008632 heme pocket [chemical binding]; other site 264730008633 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730008634 dimer interface [polypeptide binding]; other site 264730008635 putative CheW interface [polypeptide binding]; other site 264730008636 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 264730008637 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264730008638 putative active site [active] 264730008639 putative metal binding site [ion binding]; other site 264730008640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 264730008641 Transposase; Region: DEDD_Tnp_IS110; pfam01548 264730008642 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 264730008643 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 264730008644 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 264730008645 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 264730008646 DctM-like transporters; Region: DctM; pfam06808 264730008647 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 264730008648 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 264730008649 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264730008650 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730008651 catalytic residue [active] 264730008652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730008653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730008654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730008655 dimerization interface [polypeptide binding]; other site 264730008656 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264730008657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730008658 NAD(P) binding site [chemical binding]; other site 264730008659 active site 264730008660 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264730008661 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264730008662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730008663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 264730008664 classical (c) SDRs; Region: SDR_c; cd05233 264730008665 NAD(P) binding site [chemical binding]; other site 264730008666 active site 264730008667 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 264730008668 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264730008669 putative NAD(P) binding site [chemical binding]; other site 264730008670 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264730008671 nudix motif; other site 264730008672 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 264730008673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 264730008674 TspO/MBR family; Region: TspO_MBR; pfam03073 264730008675 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730008676 MULE transposase domain; Region: MULE; pfam10551 264730008677 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 264730008678 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 264730008679 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 264730008680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008681 dimer interface [polypeptide binding]; other site 264730008682 conserved gate region; other site 264730008683 putative PBP binding loops; other site 264730008684 ABC-ATPase subunit interface; other site 264730008685 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264730008686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008687 dimer interface [polypeptide binding]; other site 264730008688 conserved gate region; other site 264730008689 putative PBP binding loops; other site 264730008690 ABC-ATPase subunit interface; other site 264730008691 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264730008692 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 264730008693 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730008694 Zonular occludens toxin (Zot); Region: Zot; cl17485 264730008695 putative assembly protein; Region: PHA00350 264730008696 lysogenic prophage region; PHAGE05 264730008697 phage/plasmid replication protein, gene II/X family; Region: rep_II_X; TIGR01629 264730008698 Phage replication protein CRI; Region: Phage_CRI; pfam05144 264730008699 Phage X family; Region: Phage_X; cl11585 264730008700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264730008701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730008702 non-specific DNA binding site [nucleotide binding]; other site 264730008703 salt bridge; other site 264730008704 sequence-specific DNA binding site [nucleotide binding]; other site 264730008705 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264730008706 DNA binding site [nucleotide binding] 264730008707 active site 264730008708 Int/Topo IB signature motif; other site 264730008709 catalytic residues [active] 264730008710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 264730008711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264730008712 Transposase; Region: HTH_Tnp_1; pfam01527 264730008713 putative transposase OrfB; Reviewed; Region: PHA02517 264730008714 HTH-like domain; Region: HTH_21; pfam13276 264730008715 Integrase core domain; Region: rve; pfam00665 264730008716 Integrase core domain; Region: rve_3; pfam13683 264730008717 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730008718 MULE transposase domain; Region: MULE; pfam10551 264730008719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730008720 non-specific DNA binding site [nucleotide binding]; other site 264730008721 salt bridge; other site 264730008722 sequence-specific DNA binding site [nucleotide binding]; other site 264730008723 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264730008724 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 264730008725 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 264730008726 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264730008727 Ligand binding site; other site 264730008728 Putative Catalytic site; other site 264730008729 DXD motif; other site 264730008730 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 264730008731 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 264730008732 active site 264730008733 substrate binding site [chemical binding]; other site 264730008734 cosubstrate binding site; other site 264730008735 catalytic site [active] 264730008736 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 264730008737 active site 264730008738 hexamer interface [polypeptide binding]; other site 264730008739 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 264730008740 NAD binding site [chemical binding]; other site 264730008741 substrate binding site [chemical binding]; other site 264730008742 active site 264730008743 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 264730008744 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 264730008745 putative active site [active] 264730008746 putative catalytic site [active] 264730008747 putative Zn binding site [ion binding]; other site 264730008748 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 264730008749 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264730008750 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 264730008751 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 264730008752 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 264730008753 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 264730008754 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 264730008755 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 264730008756 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264730008757 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 264730008758 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 264730008759 catalytic core [active] 264730008760 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 264730008761 active site 264730008762 Transposase domain (DUF772); Region: DUF772; pfam05598 264730008763 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 264730008764 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730008765 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730008766 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730008767 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 264730008768 active site 264730008769 metal binding site [ion binding]; metal-binding site 264730008770 homotetramer interface [polypeptide binding]; other site 264730008771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730008772 Coenzyme A binding pocket [chemical binding]; other site 264730008773 PAAR motif; Region: PAAR_motif; pfam05488 264730008774 DYW family of nucleic acid deaminases; Region: DYW_deaminase; pfam14432 264730008775 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 264730008776 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 264730008777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730008778 Coenzyme A binding pocket [chemical binding]; other site 264730008779 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 264730008780 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 264730008781 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264730008782 Transporter associated domain; Region: CorC_HlyC; smart01091 264730008783 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 264730008784 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264730008785 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 264730008786 Predicted membrane protein [Function unknown]; Region: COG3619 264730008787 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 264730008788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730008789 S-adenosylmethionine binding site [chemical binding]; other site 264730008790 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730008791 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730008792 dimer interface [polypeptide binding]; other site 264730008793 putative CheW interface [polypeptide binding]; other site 264730008794 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264730008795 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730008796 putative DNA binding site [nucleotide binding]; other site 264730008797 putative Zn2+ binding site [ion binding]; other site 264730008798 Bacterial transcriptional regulator; Region: IclR; pfam01614 264730008799 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 264730008800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730008801 Walker A/P-loop; other site 264730008802 ATP binding site [chemical binding]; other site 264730008803 Q-loop/lid; other site 264730008804 ABC transporter signature motif; other site 264730008805 Walker B; other site 264730008806 D-loop; other site 264730008807 H-loop/switch region; other site 264730008808 TOBE domain; Region: TOBE_2; pfam08402 264730008809 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 264730008810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008811 dimer interface [polypeptide binding]; other site 264730008812 conserved gate region; other site 264730008813 putative PBP binding loops; other site 264730008814 ABC-ATPase subunit interface; other site 264730008815 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 264730008816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730008817 dimer interface [polypeptide binding]; other site 264730008818 conserved gate region; other site 264730008819 putative PBP binding loops; other site 264730008820 ABC-ATPase subunit interface; other site 264730008821 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 264730008822 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 264730008823 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 264730008824 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264730008825 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 264730008826 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 264730008827 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 264730008828 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 264730008829 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730008830 FeS/SAM binding site; other site 264730008831 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 264730008832 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 264730008833 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264730008834 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730008835 N-terminal plug; other site 264730008836 ligand-binding site [chemical binding]; other site 264730008837 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264730008838 TolR protein; Region: tolR; TIGR02801 264730008839 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264730008840 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264730008841 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264730008842 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 264730008843 active site 264730008844 catalytic site [active] 264730008845 Nitrate and nitrite sensing; Region: NIT; pfam08376 264730008846 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730008847 HAMP domain; Region: HAMP; pfam00672 264730008848 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730008849 dimer interface [polypeptide binding]; other site 264730008850 putative CheW interface [polypeptide binding]; other site 264730008851 pyruvate dehydrogenase; Provisional; Region: PRK09124 264730008852 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 264730008853 PYR/PP interface [polypeptide binding]; other site 264730008854 dimer interface [polypeptide binding]; other site 264730008855 tetramer interface [polypeptide binding]; other site 264730008856 TPP binding site [chemical binding]; other site 264730008857 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264730008858 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 264730008859 TPP-binding site [chemical binding]; other site 264730008860 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 264730008861 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264730008862 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264730008863 Predicted transcriptional regulators [Transcription]; Region: COG1733 264730008864 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 264730008865 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 264730008866 NmrA-like family; Region: NmrA; pfam05368 264730008867 NADP binding site [chemical binding]; other site 264730008868 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 264730008869 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264730008870 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264730008871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730008872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730008873 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264730008874 benzoate transport; Region: 2A0115; TIGR00895 264730008875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730008876 putative substrate translocation pore; other site 264730008877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730008878 manganese transport protein MntH; Reviewed; Region: PRK00701 264730008879 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 264730008880 benzoate transport; Region: 2A0115; TIGR00895 264730008881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730008882 putative substrate translocation pore; other site 264730008883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730008884 putative substrate translocation pore; other site 264730008885 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 264730008886 GAF domain; Region: GAF; pfam01590 264730008887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730008888 Walker A motif; other site 264730008889 ATP binding site [chemical binding]; other site 264730008890 Walker B motif; other site 264730008891 arginine finger; other site 264730008892 hypothetical protein; Validated; Region: PRK08238 264730008893 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264730008894 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 264730008895 short chain dehydrogenase; Provisional; Region: PRK07102 264730008896 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264730008897 NAD(P) binding site [chemical binding]; other site 264730008898 active site 264730008899 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 264730008900 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 264730008901 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 264730008902 glucose-1-dehydrogenase; Provisional; Region: PRK08936 264730008903 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 264730008904 NAD binding site [chemical binding]; other site 264730008905 homodimer interface [polypeptide binding]; other site 264730008906 active site 264730008907 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264730008908 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264730008909 active site 264730008910 catalytic tetrad [active] 264730008911 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730008912 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 264730008913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730008914 Walker A/P-loop; other site 264730008915 ATP binding site [chemical binding]; other site 264730008916 Q-loop/lid; other site 264730008917 ABC transporter signature motif; other site 264730008918 Walker B; other site 264730008919 D-loop; other site 264730008920 H-loop/switch region; other site 264730008921 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 264730008922 glutaminase; Provisional; Region: PRK00971 264730008923 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 264730008924 aldolase II superfamily protein; Provisional; Region: PRK07044 264730008925 active site 264730008926 intersubunit interface [polypeptide binding]; other site 264730008927 Zn2+ binding site [ion binding]; other site 264730008928 NMT1-like family; Region: NMT1_2; pfam13379 264730008929 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264730008930 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264730008931 TolR protein; Region: tolR; TIGR02801 264730008932 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264730008933 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264730008934 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264730008935 Protein of unknown function (DUF461); Region: DUF461; pfam04314 264730008936 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 264730008937 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 264730008938 Cu(I) binding site [ion binding]; other site 264730008939 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264730008940 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730008941 N-terminal plug; other site 264730008942 ligand-binding site [chemical binding]; other site 264730008943 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264730008944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730008945 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730008946 N-terminal plug; other site 264730008947 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264730008948 ligand-binding site [chemical binding]; other site 264730008949 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264730008950 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730008951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730008952 Walker A/P-loop; other site 264730008953 ATP binding site [chemical binding]; other site 264730008954 Q-loop/lid; other site 264730008955 ABC transporter signature motif; other site 264730008956 Walker B; other site 264730008957 D-loop; other site 264730008958 H-loop/switch region; other site 264730008959 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730008960 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264730008961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730008962 Walker A/P-loop; other site 264730008963 ATP binding site [chemical binding]; other site 264730008964 Q-loop/lid; other site 264730008965 ABC transporter signature motif; other site 264730008966 Walker B; other site 264730008967 D-loop; other site 264730008968 H-loop/switch region; other site 264730008969 Phosphopantetheine attachment site; Region: PP-binding; cl09936 264730008970 Condensation domain; Region: Condensation; pfam00668 264730008971 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730008972 Nonribosomal peptide synthase; Region: NRPS; pfam08415 264730008973 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 264730008974 acyl-activating enzyme (AAE) consensus motif; other site 264730008975 AMP binding site [chemical binding]; other site 264730008976 Methyltransferase domain; Region: Methyltransf_12; pfam08242 264730008977 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264730008978 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730008979 Condensation domain; Region: Condensation; pfam00668 264730008980 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730008981 Nonribosomal peptide synthase; Region: NRPS; pfam08415 264730008982 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730008983 muropeptide transporter; Validated; Region: ampG; cl17669 264730008984 muropeptide transporter; Reviewed; Region: ampG; PRK11902 264730008985 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 264730008986 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 264730008987 active site 264730008988 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264730008989 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 264730008990 Methyltransferase domain; Region: Methyltransf_12; pfam08242 264730008991 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 264730008992 KR domain; Region: KR; pfam08659 264730008993 NADP binding site [chemical binding]; other site 264730008994 active site 264730008995 Condensation domain; Region: Condensation; pfam00668 264730008996 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 264730008997 Nonribosomal peptide synthase; Region: NRPS; pfam08415 264730008998 Methyltransferase domain; Region: Methyltransf_12; pfam08242 264730008999 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730009000 Thioesterase domain; Region: Thioesterase; pfam00975 264730009001 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 264730009002 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 264730009003 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 264730009004 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 264730009005 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 264730009006 acyl-activating enzyme (AAE) consensus motif; other site 264730009007 active site 264730009008 AMP binding site [chemical binding]; other site 264730009009 substrate binding site [chemical binding]; other site 264730009010 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 264730009011 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 264730009012 chorismate binding enzyme; Region: Chorismate_bind; cl10555 264730009013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730009014 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 264730009015 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 264730009016 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730009017 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730009018 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264730009019 Protein export membrane protein; Region: SecD_SecF; cl14618 264730009020 Cache domain; Region: Cache_1; pfam02743 264730009021 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730009022 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730009023 metal binding site [ion binding]; metal-binding site 264730009024 active site 264730009025 I-site; other site 264730009026 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 264730009027 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264730009028 active site 264730009029 dimer interface [polypeptide binding]; other site 264730009030 non-prolyl cis peptide bond; other site 264730009031 insertion regions; other site 264730009032 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 264730009033 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 264730009034 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 264730009035 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 264730009036 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 264730009037 active site 264730009038 FMN binding site [chemical binding]; other site 264730009039 substrate binding site [chemical binding]; other site 264730009040 3Fe-4S cluster binding site [ion binding]; other site 264730009041 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 264730009042 domain_subunit interface; other site 264730009043 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 264730009044 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 264730009045 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 264730009046 putative active site [active] 264730009047 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 264730009048 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264730009049 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264730009050 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 264730009051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730009052 non-specific DNA binding site [nucleotide binding]; other site 264730009053 salt bridge; other site 264730009054 sequence-specific DNA binding site [nucleotide binding]; other site 264730009055 Cupin domain; Region: Cupin_2; pfam07883 264730009056 Predicted membrane protein [Function unknown]; Region: COG3503 264730009057 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264730009058 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 264730009059 trimer interface [polypeptide binding]; other site 264730009060 active site 264730009061 putative GTP cyclohydrolase; Provisional; Region: PRK13674 264730009062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730009063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730009064 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730009065 dimerization interface [polypeptide binding]; other site 264730009066 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264730009067 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 264730009068 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 264730009069 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 264730009070 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 264730009071 Trp docking motif [polypeptide binding]; other site 264730009072 putative active site [active] 264730009073 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 264730009074 putative hydrolase; Provisional; Region: PRK02113 264730009075 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Region: phosphon_PhnN; TIGR02322 264730009076 AAA domain; Region: AAA_18; pfam13238 264730009077 active site 264730009078 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 264730009079 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264730009080 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 264730009081 active site 264730009082 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 264730009083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730009084 Walker A/P-loop; other site 264730009085 ATP binding site [chemical binding]; other site 264730009086 Q-loop/lid; other site 264730009087 ABC transporter signature motif; other site 264730009088 Walker B; other site 264730009089 D-loop; other site 264730009090 H-loop/switch region; other site 264730009091 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 264730009092 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730009093 Walker A/P-loop; other site 264730009094 ATP binding site [chemical binding]; other site 264730009095 Q-loop/lid; other site 264730009096 ABC transporter signature motif; other site 264730009097 Walker B; other site 264730009098 D-loop; other site 264730009099 H-loop/switch region; other site 264730009100 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730009101 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 264730009102 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 264730009103 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 264730009104 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 264730009105 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264730009106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730009107 DNA-binding site [nucleotide binding]; DNA binding site 264730009108 UTRA domain; Region: UTRA; pfam07702 264730009109 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 264730009110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730009111 dimer interface [polypeptide binding]; other site 264730009112 conserved gate region; other site 264730009113 ABC-ATPase subunit interface; other site 264730009114 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 264730009115 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 264730009116 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 264730009117 Walker A/P-loop; other site 264730009118 ATP binding site [chemical binding]; other site 264730009119 Q-loop/lid; other site 264730009120 ABC transporter signature motif; other site 264730009121 Walker B; other site 264730009122 D-loop; other site 264730009123 H-loop/switch region; other site 264730009124 Cache domain; Region: Cache_1; pfam02743 264730009125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730009126 dimerization interface [polypeptide binding]; other site 264730009127 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730009128 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730009129 dimer interface [polypeptide binding]; other site 264730009130 putative CheW interface [polypeptide binding]; other site 264730009131 HDOD domain; Region: HDOD; pfam08668 264730009132 HD domain; Region: HD; pfam01966 264730009133 DNA topoisomerase III; Provisional; Region: PRK07726 264730009134 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 264730009135 active site 264730009136 putative interdomain interaction site [polypeptide binding]; other site 264730009137 putative metal-binding site [ion binding]; other site 264730009138 putative nucleotide binding site [chemical binding]; other site 264730009139 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264730009140 domain I; other site 264730009141 DNA binding groove [nucleotide binding] 264730009142 phosphate binding site [ion binding]; other site 264730009143 domain II; other site 264730009144 domain III; other site 264730009145 nucleotide binding site [chemical binding]; other site 264730009146 catalytic site [active] 264730009147 domain IV; other site 264730009148 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 264730009149 homotrimer interaction site [polypeptide binding]; other site 264730009150 putative active site [active] 264730009151 HAMP domain; Region: HAMP; pfam00672 264730009152 dimerization interface [polypeptide binding]; other site 264730009153 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730009154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730009155 dimer interface [polypeptide binding]; other site 264730009156 putative CheW interface [polypeptide binding]; other site 264730009157 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730009158 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730009159 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 264730009160 dimerization interface [polypeptide binding]; other site 264730009161 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730009162 dimer interface [polypeptide binding]; other site 264730009163 putative CheW interface [polypeptide binding]; other site 264730009164 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 264730009165 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 264730009166 active site 264730009167 substrate binding site [chemical binding]; other site 264730009168 Mg2+ binding site [ion binding]; other site 264730009169 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 264730009170 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264730009171 putative ligand binding site [chemical binding]; other site 264730009172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730009173 dimerization interface [polypeptide binding]; other site 264730009174 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730009175 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730009176 dimer interface [polypeptide binding]; other site 264730009177 putative CheW interface [polypeptide binding]; other site 264730009178 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 264730009179 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 264730009180 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 264730009181 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 264730009182 Strictosidine synthase; Region: Str_synth; pfam03088 264730009183 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 264730009184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730009185 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730009186 putative substrate translocation pore; other site 264730009187 Predicted amidohydrolase [General function prediction only]; Region: COG0388 264730009188 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 264730009189 active site 264730009190 catalytic triad [active] 264730009191 dimer interface [polypeptide binding]; other site 264730009192 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 264730009193 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 264730009194 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264730009195 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730009196 N-terminal plug; other site 264730009197 ligand-binding site [chemical binding]; other site 264730009198 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 264730009199 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 264730009200 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 264730009201 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 264730009202 putative active site [active] 264730009203 putative substrate binding site [chemical binding]; other site 264730009204 putative cosubstrate binding site; other site 264730009205 catalytic site [active] 264730009206 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194 264730009207 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 264730009208 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 264730009209 homodimer interface [polypeptide binding]; other site 264730009210 NADP binding site [chemical binding]; other site 264730009211 substrate binding site [chemical binding]; other site 264730009212 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 264730009213 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264730009214 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 264730009215 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 264730009216 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 264730009217 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264730009218 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 264730009219 Cache domain; Region: Cache_1; pfam02743 264730009220 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730009221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730009222 dimerization interface [polypeptide binding]; other site 264730009223 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730009224 dimer interface [polypeptide binding]; other site 264730009225 putative CheW interface [polypeptide binding]; other site 264730009226 transcriptional regulator; Provisional; Region: PRK10632 264730009227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730009228 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264730009229 putative effector binding pocket; other site 264730009230 dimerization interface [polypeptide binding]; other site 264730009231 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264730009232 CheW-like domain; Region: CheW; pfam01584 264730009233 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 264730009234 CheW-like domain; Region: CheW; pfam01584 264730009235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730009236 PAS domain; Region: PAS_9; pfam13426 264730009237 putative active site [active] 264730009238 heme pocket [chemical binding]; other site 264730009239 PAS domain; Region: PAS_9; pfam13426 264730009240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730009241 putative active site [active] 264730009242 heme pocket [chemical binding]; other site 264730009243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730009244 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264730009245 putative active site [active] 264730009246 heme pocket [chemical binding]; other site 264730009247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730009248 putative active site [active] 264730009249 heme pocket [chemical binding]; other site 264730009250 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730009251 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730009252 dimer interface [polypeptide binding]; other site 264730009253 putative CheW interface [polypeptide binding]; other site 264730009254 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 264730009255 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 264730009256 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 264730009257 active site 264730009258 non-prolyl cis peptide bond; other site 264730009259 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180 264730009260 putative ligand binding site [chemical binding]; other site 264730009261 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264730009262 putative NAD binding site [chemical binding]; other site 264730009263 catalytic site [active] 264730009264 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264730009265 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730009266 substrate binding pocket [chemical binding]; other site 264730009267 membrane-bound complex binding site; other site 264730009268 hinge residues; other site 264730009269 amidase; Provisional; Region: PRK07235 264730009270 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264730009271 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 264730009272 ANTAR domain; Region: ANTAR; pfam03861 264730009273 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264730009274 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 264730009275 ligand binding site [chemical binding]; other site 264730009276 regulator interaction site; other site 264730009277 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730009278 MULE transposase domain; Region: MULE; pfam10551 264730009279 HAMP domain; Region: HAMP; pfam00672 264730009280 dimerization interface [polypeptide binding]; other site 264730009281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730009282 dimer interface [polypeptide binding]; other site 264730009283 phosphorylation site [posttranslational modification] 264730009284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730009285 ATP binding site [chemical binding]; other site 264730009286 Mg2+ binding site [ion binding]; other site 264730009287 G-X-G motif; other site 264730009288 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264730009289 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264730009290 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264730009291 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264730009292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730009293 DNA-binding site [nucleotide binding]; DNA binding site 264730009294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730009295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730009296 homodimer interface [polypeptide binding]; other site 264730009297 catalytic residue [active] 264730009298 HTH domain; Region: HTH_11; pfam08279 264730009299 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264730009300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730009301 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 264730009302 dimerization interface [polypeptide binding]; other site 264730009303 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730009304 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730009305 dimer interface [polypeptide binding]; other site 264730009306 putative CheW interface [polypeptide binding]; other site 264730009307 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264730009308 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264730009309 TolR protein; Region: tolR; TIGR02801 264730009310 TolQ protein; Region: tolQ; TIGR02796 264730009311 Phytase; Region: Phytase; cl17685 264730009312 Phytase; Region: Phytase; cl17685 264730009313 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 264730009314 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264730009315 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730009316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730009317 metal binding site [ion binding]; metal-binding site 264730009318 active site 264730009319 I-site; other site 264730009320 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264730009321 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264730009322 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264730009323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730009324 active site 264730009325 phosphorylation site [posttranslational modification] 264730009326 intermolecular recognition site; other site 264730009327 dimerization interface [polypeptide binding]; other site 264730009328 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730009329 DNA binding site [nucleotide binding] 264730009330 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 264730009331 active site 264730009332 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 264730009333 catalytic core [active] 264730009334 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 264730009335 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 264730009336 putative active site pocket [active] 264730009337 metal binding site [ion binding]; metal-binding site 264730009338 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 264730009339 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264730009340 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264730009341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730009342 dimer interface [polypeptide binding]; other site 264730009343 conserved gate region; other site 264730009344 putative PBP binding loops; other site 264730009345 ABC-ATPase subunit interface; other site 264730009346 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 264730009347 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 264730009348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730009349 dimer interface [polypeptide binding]; other site 264730009350 conserved gate region; other site 264730009351 ABC-ATPase subunit interface; other site 264730009352 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 264730009353 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730009354 Walker A/P-loop; other site 264730009355 ATP binding site [chemical binding]; other site 264730009356 Q-loop/lid; other site 264730009357 ABC transporter signature motif; other site 264730009358 Walker B; other site 264730009359 D-loop; other site 264730009360 H-loop/switch region; other site 264730009361 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730009362 Walker A/P-loop; other site 264730009363 ATP binding site [chemical binding]; other site 264730009364 Q-loop/lid; other site 264730009365 ABC transporter signature motif; other site 264730009366 Walker B; other site 264730009367 D-loop; other site 264730009368 H-loop/switch region; other site 264730009369 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 264730009370 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730009371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730009372 DNA-binding site [nucleotide binding]; DNA binding site 264730009373 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264730009374 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730009375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730009376 DNA-binding site [nucleotide binding]; DNA binding site 264730009377 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264730009378 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 264730009379 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 264730009380 putative ligand binding residues [chemical binding]; other site 264730009381 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 264730009382 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264730009383 ABC-ATPase subunit interface; other site 264730009384 dimer interface [polypeptide binding]; other site 264730009385 putative PBP binding regions; other site 264730009386 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264730009387 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 264730009388 Walker A/P-loop; other site 264730009389 ATP binding site [chemical binding]; other site 264730009390 Q-loop/lid; other site 264730009391 ABC transporter signature motif; other site 264730009392 Walker B; other site 264730009393 D-loop; other site 264730009394 H-loop/switch region; other site 264730009395 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 264730009396 Peptidase family U32; Region: Peptidase_U32; pfam01136 264730009397 Collagenase; Region: DUF3656; pfam12392 264730009398 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 264730009399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730009400 Coenzyme A binding pocket [chemical binding]; other site 264730009401 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 264730009402 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 264730009403 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264730009404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730009405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730009406 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 264730009407 putative substrate binding pocket [chemical binding]; other site 264730009408 putative dimerization interface [polypeptide binding]; other site 264730009409 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 264730009410 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 264730009411 Walker A/P-loop; other site 264730009412 ATP binding site [chemical binding]; other site 264730009413 Q-loop/lid; other site 264730009414 ABC transporter signature motif; other site 264730009415 Walker B; other site 264730009416 D-loop; other site 264730009417 H-loop/switch region; other site 264730009418 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 264730009419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730009420 dimer interface [polypeptide binding]; other site 264730009421 conserved gate region; other site 264730009422 putative PBP binding loops; other site 264730009423 ABC-ATPase subunit interface; other site 264730009424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730009425 dimer interface [polypeptide binding]; other site 264730009426 conserved gate region; other site 264730009427 putative PBP binding loops; other site 264730009428 ABC-ATPase subunit interface; other site 264730009429 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 264730009430 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 264730009431 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 264730009432 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730009433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730009434 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 264730009435 putative dimerization interface [polypeptide binding]; other site 264730009436 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 264730009437 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 264730009438 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 264730009439 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 264730009440 putative active cleft [active] 264730009441 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730009442 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730009443 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730009444 dimerization interface [polypeptide binding]; other site 264730009445 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730009446 dimer interface [polypeptide binding]; other site 264730009447 putative CheW interface [polypeptide binding]; other site 264730009448 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 264730009449 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 264730009450 Avirulence protein; Region: AvrB_AvrC; pfam05394 264730009451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730009452 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730009453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730009454 DNA-binding site [nucleotide binding]; DNA binding site 264730009455 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264730009456 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 264730009457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730009458 putative substrate translocation pore; other site 264730009459 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 264730009460 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 264730009461 dimerization interface [polypeptide binding]; other site 264730009462 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264730009463 NAD binding site [chemical binding]; other site 264730009464 ligand binding site [chemical binding]; other site 264730009465 catalytic site [active] 264730009466 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 264730009467 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264730009468 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730009469 N-terminal plug; other site 264730009470 ligand-binding site [chemical binding]; other site 264730009471 Isochorismatase family; Region: Isochorismatase; pfam00857 264730009472 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 264730009473 catalytic triad [active] 264730009474 metal binding site [ion binding]; metal-binding site 264730009475 conserved cis-peptide bond; other site 264730009476 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 264730009477 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264730009478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730009479 active site 264730009480 phosphorylation site [posttranslational modification] 264730009481 intermolecular recognition site; other site 264730009482 dimerization interface [polypeptide binding]; other site 264730009483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730009484 DNA binding site [nucleotide binding] 264730009485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730009486 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730009487 dimerization interface [polypeptide binding]; other site 264730009488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730009489 dimer interface [polypeptide binding]; other site 264730009490 phosphorylation site [posttranslational modification] 264730009491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730009492 ATP binding site [chemical binding]; other site 264730009493 Mg2+ binding site [ion binding]; other site 264730009494 G-X-G motif; other site 264730009495 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730009496 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264730009497 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730009498 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730009499 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264730009500 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730009501 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730009502 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264730009503 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264730009504 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264730009505 active site 264730009506 benzoate transport; Region: 2A0115; TIGR00895 264730009507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730009508 putative substrate translocation pore; other site 264730009509 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264730009510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730009511 DNA-binding site [nucleotide binding]; DNA binding site 264730009512 UTRA domain; Region: UTRA; pfam07702 264730009513 TIGR02646 family protein; Region: TIGR02646 264730009514 P-loop containing region of AAA domain; Region: AAA_29; cl17516 264730009515 AAA domain; Region: AAA_21; pfam13304 264730009516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 264730009517 Q-loop/lid; other site 264730009518 ABC transporter signature motif; other site 264730009519 Walker B; other site 264730009520 D-loop; other site 264730009521 H-loop/switch region; other site 264730009522 Predicted esterase [General function prediction only]; Region: COG0400 264730009523 putative hydrolase; Provisional; Region: PRK11460 264730009524 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264730009525 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264730009526 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264730009527 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 264730009528 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264730009529 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 264730009530 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 264730009531 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 264730009532 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 264730009533 general secretion pathway protein J; Validated; Region: PRK08808 264730009534 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 264730009535 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 264730009536 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 264730009537 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 264730009538 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 264730009539 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 264730009540 type II secretion system protein F; Region: GspF; TIGR02120 264730009541 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264730009542 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264730009543 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 264730009544 type II secretion system protein E; Region: type_II_gspE; TIGR02533 264730009545 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264730009546 Walker A motif; other site 264730009547 ATP binding site [chemical binding]; other site 264730009548 Walker B motif; other site 264730009549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730009550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730009551 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 264730009552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730009553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730009554 putative substrate translocation pore; other site 264730009555 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 264730009556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730009557 Coenzyme A binding pocket [chemical binding]; other site 264730009558 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 264730009559 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 264730009560 dimer interface [polypeptide binding]; other site 264730009561 NADP binding site [chemical binding]; other site 264730009562 catalytic residues [active] 264730009563 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 264730009564 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264730009565 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264730009566 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 264730009567 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730009568 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730009569 Protease inhibitor Inh; Region: Inh; pfam02974 264730009570 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 264730009571 YccA-like proteins; Region: YccA_like; cd10433 264730009572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730009573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730009574 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264730009575 putative dimerization interface [polypeptide binding]; other site 264730009576 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264730009577 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264730009578 citrate-proton symporter; Provisional; Region: PRK15075 264730009579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730009580 putative substrate translocation pore; other site 264730009581 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 264730009582 sulfur relay protein TusC; Validated; Region: PRK00211 264730009583 DsrH like protein; Region: DsrH; cl17347 264730009584 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 264730009585 DsrC like protein; Region: DsrC; pfam04358 264730009586 hypothetical protein; Validated; Region: PRK09071 264730009587 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264730009588 siroheme synthase; Provisional; Region: cysG; PRK10637 264730009589 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 264730009590 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 264730009591 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 264730009592 active site 264730009593 SAM binding site [chemical binding]; other site 264730009594 homodimer interface [polypeptide binding]; other site 264730009595 seryl-tRNA synthetase; Provisional; Region: PRK05431 264730009596 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 264730009597 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 264730009598 dimer interface [polypeptide binding]; other site 264730009599 active site 264730009600 motif 1; other site 264730009601 motif 2; other site 264730009602 motif 3; other site 264730009603 camphor resistance protein CrcB; Provisional; Region: PRK14234 264730009604 recombination factor protein RarA; Reviewed; Region: PRK13342 264730009605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730009606 Walker A motif; other site 264730009607 ATP binding site [chemical binding]; other site 264730009608 Walker B motif; other site 264730009609 arginine finger; other site 264730009610 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 264730009611 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 264730009612 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 264730009613 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 264730009614 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 264730009615 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 264730009616 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 264730009617 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 264730009618 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 264730009619 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 264730009620 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264730009621 rRNA binding site [nucleotide binding]; other site 264730009622 predicted 30S ribosome binding site; other site 264730009623 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 264730009624 Clp amino terminal domain; Region: Clp_N; pfam02861 264730009625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730009626 Walker A motif; other site 264730009627 ATP binding site [chemical binding]; other site 264730009628 Walker B motif; other site 264730009629 arginine finger; other site 264730009630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730009631 Walker A motif; other site 264730009632 ATP binding site [chemical binding]; other site 264730009633 Walker B motif; other site 264730009634 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 264730009635 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 264730009636 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264730009637 DNA-binding site [nucleotide binding]; DNA binding site 264730009638 RNA-binding motif; other site 264730009639 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 264730009640 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 264730009641 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 264730009642 nudix motif; other site 264730009643 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 264730009644 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 264730009645 putative lysogenization regulator; Reviewed; Region: PRK00218 264730009646 adenylosuccinate lyase; Provisional; Region: PRK09285 264730009647 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 264730009648 tetramer interface [polypeptide binding]; other site 264730009649 active site 264730009650 Uncharacterized conserved protein [Function unknown]; Region: COG2850 264730009651 Cupin domain; Region: Cupin_2; cl17218 264730009652 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264730009653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730009654 Coenzyme A binding pocket [chemical binding]; other site 264730009655 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264730009656 isocitrate lyase; Provisional; Region: PRK15063 264730009657 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264730009658 tetramer interface [polypeptide binding]; other site 264730009659 active site 264730009660 Mg2+/Mn2+ binding site [ion binding]; other site 264730009661 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 264730009662 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 264730009663 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 264730009664 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 264730009665 NADH dehydrogenase subunit D; Validated; Region: PRK06075 264730009666 NADH dehydrogenase subunit E; Validated; Region: PRK07539 264730009667 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 264730009668 putative dimer interface [polypeptide binding]; other site 264730009669 [2Fe-2S] cluster binding site [ion binding]; other site 264730009670 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 264730009671 SLBB domain; Region: SLBB; pfam10531 264730009672 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 264730009673 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264730009674 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 264730009675 catalytic loop [active] 264730009676 iron binding site [ion binding]; other site 264730009677 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 264730009678 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 264730009679 [4Fe-4S] binding site [ion binding]; other site 264730009680 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 264730009681 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 264730009682 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 264730009683 4Fe-4S binding domain; Region: Fer4; pfam00037 264730009684 4Fe-4S binding domain; Region: Fer4; pfam00037 264730009685 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 264730009686 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 264730009687 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 264730009688 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 264730009689 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 264730009690 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 264730009691 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264730009692 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 264730009693 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264730009694 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 264730009695 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264730009696 Cupin; Region: Cupin_6; pfam12852 264730009697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730009698 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264730009699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730009700 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264730009701 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 264730009702 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264730009703 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 264730009704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730009705 dimerization interface [polypeptide binding]; other site 264730009706 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730009707 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730009708 dimer interface [polypeptide binding]; other site 264730009709 putative CheW interface [polypeptide binding]; other site 264730009710 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264730009711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730009712 ATP binding site [chemical binding]; other site 264730009713 Mg2+ binding site [ion binding]; other site 264730009714 G-X-G motif; other site 264730009715 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 264730009716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730009717 active site 264730009718 phosphorylation site [posttranslational modification] 264730009719 intermolecular recognition site; other site 264730009720 dimerization interface [polypeptide binding]; other site 264730009721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730009722 DNA binding site [nucleotide binding] 264730009723 Predicted membrane protein [Function unknown]; Region: COG3212 264730009724 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 264730009725 Predicted membrane protein [Function unknown]; Region: COG3212 264730009726 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 264730009727 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 264730009728 active site 264730009729 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264730009730 EamA-like transporter family; Region: EamA; pfam00892 264730009731 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 264730009732 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264730009733 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264730009734 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 264730009735 active site 264730009736 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264730009737 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 264730009738 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730009739 catalytic residue [active] 264730009740 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 264730009741 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264730009742 inhibitor-cofactor binding pocket; inhibition site 264730009743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730009744 catalytic residue [active] 264730009745 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 264730009746 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 264730009747 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264730009748 active site 264730009749 Low molecular weight phosphatase family; Region: LMWPc; cd00115 264730009750 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 264730009751 active site 264730009752 tyrosine kinase; Provisional; Region: PRK11519 264730009753 Chain length determinant protein; Region: Wzz; pfam02706 264730009754 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 264730009755 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 264730009756 Nucleotide binding site [chemical binding]; other site 264730009757 P loop; other site 264730009758 DTAP/Switch II; other site 264730009759 Switch I; other site 264730009760 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 264730009761 transcriptional activator RfaH; Region: RfaH; TIGR01955 264730009762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730009763 active site 264730009764 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 264730009765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730009766 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 264730009767 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730009768 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 264730009769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730009770 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 264730009771 putative ADP-binding pocket [chemical binding]; other site 264730009772 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 264730009773 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 264730009774 Bacterial sugar transferase; Region: Bac_transf; pfam02397 264730009775 polysaccharide export protein Wza; Provisional; Region: PRK15078 264730009776 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 264730009777 SLBB domain; Region: SLBB; pfam10531 264730009778 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264730009779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730009780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730009781 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264730009782 putative dimerization interface [polypeptide binding]; other site 264730009783 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 264730009784 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 264730009785 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 264730009786 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 264730009787 hypothetical protein; Validated; Region: PRK06186 264730009788 conserved cys residue [active] 264730009789 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 264730009790 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 264730009791 putative ligand binding site [chemical binding]; other site 264730009792 NAD binding site [chemical binding]; other site 264730009793 catalytic site [active] 264730009794 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 264730009795 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 264730009796 active site 264730009797 catalytic site [active] 264730009798 metal binding site [ion binding]; metal-binding site 264730009799 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264730009800 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730009801 N-terminal plug; other site 264730009802 ligand-binding site [chemical binding]; other site 264730009803 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 264730009804 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 264730009805 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 264730009806 active site 264730009807 DNA binding site [nucleotide binding] 264730009808 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 264730009809 DNA binding site [nucleotide binding] 264730009810 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 264730009811 nucleotide binding site [chemical binding]; other site 264730009812 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 264730009813 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 264730009814 putative DNA binding site [nucleotide binding]; other site 264730009815 putative homodimer interface [polypeptide binding]; other site 264730009816 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 264730009817 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264730009818 active site 264730009819 dimer interface [polypeptide binding]; other site 264730009820 non-prolyl cis peptide bond; other site 264730009821 insertion regions; other site 264730009822 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264730009823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730009824 Walker A motif; other site 264730009825 ATP binding site [chemical binding]; other site 264730009826 Walker B motif; other site 264730009827 arginine finger; other site 264730009828 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 264730009829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 264730009830 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 264730009831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730009832 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 264730009833 non-specific DNA binding site [nucleotide binding]; other site 264730009834 salt bridge; other site 264730009835 sequence-specific DNA binding site [nucleotide binding]; other site 264730009836 Cupin domain; Region: Cupin_2; pfam07883 264730009837 EamA-like transporter family; Region: EamA; pfam00892 264730009838 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264730009839 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 264730009840 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264730009841 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 264730009842 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 264730009843 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 264730009844 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 264730009845 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 264730009846 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 264730009847 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 264730009848 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 264730009849 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 264730009850 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730009851 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730009852 dimer interface [polypeptide binding]; other site 264730009853 putative CheW interface [polypeptide binding]; other site 264730009854 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 264730009855 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730009856 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264730009857 TM-ABC transporter signature motif; other site 264730009858 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 264730009859 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264730009860 Walker A/P-loop; other site 264730009861 ATP binding site [chemical binding]; other site 264730009862 Q-loop/lid; other site 264730009863 ABC transporter signature motif; other site 264730009864 Walker B; other site 264730009865 D-loop; other site 264730009866 H-loop/switch region; other site 264730009867 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264730009868 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 264730009869 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264730009870 putative ligand binding site [chemical binding]; other site 264730009871 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 264730009872 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 264730009873 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 264730009874 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 264730009875 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264730009876 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 264730009877 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 264730009878 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 264730009879 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 264730009880 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264730009881 PYR/PP interface [polypeptide binding]; other site 264730009882 dimer interface [polypeptide binding]; other site 264730009883 TPP binding site [chemical binding]; other site 264730009884 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264730009885 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 264730009886 TPP-binding site; other site 264730009887 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 264730009888 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264730009889 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 264730009890 tetrameric interface [polypeptide binding]; other site 264730009891 NAD binding site [chemical binding]; other site 264730009892 catalytic residues [active] 264730009893 KduI/IolB family; Region: KduI; pfam04962 264730009894 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264730009895 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264730009896 putative active site [active] 264730009897 Predicted integral membrane protein [Function unknown]; Region: COG0392 264730009898 cardiolipin synthase 2; Provisional; Region: PRK11263 264730009899 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 264730009900 putative active site [active] 264730009901 catalytic site [active] 264730009902 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 264730009903 putative active site [active] 264730009904 catalytic site [active] 264730009905 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 264730009906 putative catalytic site [active] 264730009907 putative metal binding site [ion binding]; other site 264730009908 putative phosphate binding site [ion binding]; other site 264730009909 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 264730009910 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 264730009911 beta-hexosaminidase; Provisional; Region: PRK05337 264730009912 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264730009913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730009914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730009915 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 264730009916 LexA repressor; Validated; Region: PRK00215 264730009917 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 264730009918 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264730009919 Catalytic site [active] 264730009920 Cell division inhibitor SulA; Region: SulA; cl01880 264730009921 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 264730009922 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 264730009923 active site 264730009924 interdomain interaction site; other site 264730009925 putative metal-binding site [ion binding]; other site 264730009926 nucleotide binding site [chemical binding]; other site 264730009927 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264730009928 domain I; other site 264730009929 DNA binding groove [nucleotide binding] 264730009930 phosphate binding site [ion binding]; other site 264730009931 domain II; other site 264730009932 domain III; other site 264730009933 nucleotide binding site [chemical binding]; other site 264730009934 catalytic site [active] 264730009935 domain IV; other site 264730009936 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264730009937 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264730009938 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 264730009939 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 264730009940 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 264730009941 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 264730009942 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264730009943 dimer interface [polypeptide binding]; other site 264730009944 active site 264730009945 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 264730009946 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264730009947 substrate binding site [chemical binding]; other site 264730009948 oxyanion hole (OAH) forming residues; other site 264730009949 trimer interface [polypeptide binding]; other site 264730009950 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264730009951 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264730009952 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264730009953 Ligand Binding Site [chemical binding]; other site 264730009954 ABC transporter ATPase component; Reviewed; Region: PRK11147 264730009955 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264730009956 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264730009957 ABC transporter; Region: ABC_tran_2; pfam12848 264730009958 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264730009959 lytic murein transglycosylase; Provisional; Region: PRK11619 264730009960 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264730009961 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264730009962 catalytic residue [active] 264730009963 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 264730009964 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 264730009965 MOSC domain; Region: MOSC; pfam03473 264730009966 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 264730009967 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730009968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730009969 active site 264730009970 phosphorylation site [posttranslational modification] 264730009971 intermolecular recognition site; other site 264730009972 dimerization interface [polypeptide binding]; other site 264730009973 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730009974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730009975 active site 264730009976 phosphorylation site [posttranslational modification] 264730009977 intermolecular recognition site; other site 264730009978 dimerization interface [polypeptide binding]; other site 264730009979 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730009980 DNA binding residues [nucleotide binding] 264730009981 lipid kinase; Reviewed; Region: PRK13054 264730009982 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 264730009983 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 264730009984 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 264730009985 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 264730009986 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 264730009987 Substrate binding site; other site 264730009988 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 264730009989 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 264730009990 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 264730009991 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 264730009992 Chain length determinant protein; Region: Wzz; cl15801 264730009993 Chain length determinant protein; Region: Wzz; cl15801 264730009994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730009995 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 264730009996 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 264730009997 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264730009998 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 264730009999 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730010000 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 264730010001 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 264730010002 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 264730010003 trimer interface [polypeptide binding]; other site 264730010004 active site 264730010005 substrate binding site [chemical binding]; other site 264730010006 CoA binding site [chemical binding]; other site 264730010007 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 264730010008 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264730010009 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 264730010010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730010011 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 264730010012 putative dimerization interface [polypeptide binding]; other site 264730010013 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730010014 MULE transposase domain; Region: MULE; pfam10551 264730010015 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 264730010016 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 264730010017 gating phenylalanine in ion channel; other site 264730010018 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 264730010019 active site 264730010020 catalytic residues [active] 264730010021 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 264730010022 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 264730010023 potential catalytic triad [active] 264730010024 conserved cys residue [active] 264730010025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730010026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730010027 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 264730010028 substrate binding pocket [chemical binding]; other site 264730010029 dimerization interface [polypeptide binding]; other site 264730010030 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 264730010031 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 264730010032 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 264730010033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730010034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730010035 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 264730010036 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 264730010037 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 264730010038 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264730010039 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 264730010040 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264730010041 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264730010042 Bacterial transcriptional regulator; Region: IclR; pfam01614 264730010043 Cache domain; Region: Cache_1; pfam02743 264730010044 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730010045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730010046 metal binding site [ion binding]; metal-binding site 264730010047 active site 264730010048 I-site; other site 264730010049 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 264730010050 GAF domain; Region: GAF; pfam01590 264730010051 PAS domain S-box; Region: sensory_box; TIGR00229 264730010052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730010053 putative active site [active] 264730010054 heme pocket [chemical binding]; other site 264730010055 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730010056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730010057 metal binding site [ion binding]; metal-binding site 264730010058 active site 264730010059 I-site; other site 264730010060 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730010061 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 264730010062 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 264730010063 dimer interface [polypeptide binding]; other site 264730010064 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 264730010065 active site 264730010066 Fe binding site [ion binding]; other site 264730010067 maleylacetoacetate isomerase; Region: maiA; TIGR01262 264730010068 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264730010069 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 264730010070 dimer interface [polypeptide binding]; other site 264730010071 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 264730010072 N-terminal domain interface [polypeptide binding]; other site 264730010073 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 264730010074 FAD binding domain; Region: FAD_binding_4; pfam01565 264730010075 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 264730010076 FAD binding domain; Region: FAD_binding_4; pfam01565 264730010077 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 264730010078 Cysteine-rich domain; Region: CCG; pfam02754 264730010079 Cysteine-rich domain; Region: CCG; pfam02754 264730010080 Domain of unknown function (DUF336); Region: DUF336; cl01249 264730010081 Uncharacterized conserved protein [Function unknown]; Region: COG3391 264730010082 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264730010083 structural tetrad; other site 264730010084 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264730010085 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264730010086 DNA binding site [nucleotide binding] 264730010087 domain linker motif; other site 264730010088 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 264730010089 putative dimerization interface [polypeptide binding]; other site 264730010090 putative ligand binding site [chemical binding]; other site 264730010091 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 264730010092 AAA domain; Region: AAA_33; pfam13671 264730010093 ATP-binding site [chemical binding]; other site 264730010094 Gluconate-6-phosphate binding site [chemical binding]; other site 264730010095 fructuronate transporter; Provisional; Region: PRK10034; cl15264 264730010096 GntP family permease; Region: GntP_permease; pfam02447 264730010097 carbon storage regulator; Provisional; Region: PRK01712 264730010098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 264730010099 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 264730010100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 264730010101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730010102 Coenzyme A binding pocket [chemical binding]; other site 264730010103 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264730010104 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264730010105 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264730010106 putative acetyltransferase; Provisional; Region: PRK03624 264730010107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730010108 Coenzyme A binding pocket [chemical binding]; other site 264730010109 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264730010110 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730010111 N-terminal plug; other site 264730010112 ligand-binding site [chemical binding]; other site 264730010113 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 264730010114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730010115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730010116 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 264730010117 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730010118 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730010119 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730010120 dimerization interface [polypeptide binding]; other site 264730010121 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730010122 dimer interface [polypeptide binding]; other site 264730010123 putative CheW interface [polypeptide binding]; other site 264730010124 SnoaL-like domain; Region: SnoaL_3; pfam13474 264730010125 SnoaL-like domain; Region: SnoaL_2; pfam12680 264730010126 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 264730010127 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 264730010128 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 264730010129 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730010130 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730010131 dimerization interface [polypeptide binding]; other site 264730010132 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730010133 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730010134 dimer interface [polypeptide binding]; other site 264730010135 putative CheW interface [polypeptide binding]; other site 264730010136 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264730010137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730010138 Coenzyme A binding pocket [chemical binding]; other site 264730010139 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 264730010140 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 264730010141 tetramer interface [polypeptide binding]; other site 264730010142 heme binding pocket [chemical binding]; other site 264730010143 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 264730010144 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264730010145 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264730010146 PAS domain S-box; Region: sensory_box; TIGR00229 264730010147 PAS fold; Region: PAS_4; pfam08448 264730010148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730010149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730010150 dimer interface [polypeptide binding]; other site 264730010151 phosphorylation site [posttranslational modification] 264730010152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730010153 ATP binding site [chemical binding]; other site 264730010154 Mg2+ binding site [ion binding]; other site 264730010155 G-X-G motif; other site 264730010156 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730010157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010158 active site 264730010159 phosphorylation site [posttranslational modification] 264730010160 intermolecular recognition site; other site 264730010161 dimerization interface [polypeptide binding]; other site 264730010162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730010163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730010164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264730010165 dimerization interface [polypeptide binding]; other site 264730010166 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 264730010167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730010168 putative substrate translocation pore; other site 264730010169 Predicted ATPase [General function prediction only]; Region: COG1485 264730010170 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264730010171 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 264730010172 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264730010173 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264730010174 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 264730010175 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264730010176 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 264730010177 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 264730010178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730010179 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730010180 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 264730010181 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264730010182 DNA binding site [nucleotide binding] 264730010183 active site 264730010184 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264730010185 endonuclease III; Region: ENDO3c; smart00478 264730010186 minor groove reading motif; other site 264730010187 helix-hairpin-helix signature motif; other site 264730010188 substrate binding pocket [chemical binding]; other site 264730010189 active site 264730010190 Iron permease FTR1 family; Region: FTR1; cl00475 264730010191 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 264730010192 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 264730010193 Imelysin; Region: Peptidase_M75; pfam09375 264730010194 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 264730010195 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 264730010196 Imelysin; Region: Peptidase_M75; pfam09375 264730010197 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 264730010198 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 264730010199 Moco binding site; other site 264730010200 metal coordination site [ion binding]; other site 264730010201 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 264730010202 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 264730010203 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 264730010204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010205 active site 264730010206 phosphorylation site [posttranslational modification] 264730010207 intermolecular recognition site; other site 264730010208 dimerization interface [polypeptide binding]; other site 264730010209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730010210 DNA binding site [nucleotide binding] 264730010211 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264730010212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730010213 dimer interface [polypeptide binding]; other site 264730010214 phosphorylation site [posttranslational modification] 264730010215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730010216 ATP binding site [chemical binding]; other site 264730010217 Mg2+ binding site [ion binding]; other site 264730010218 G-X-G motif; other site 264730010219 Alginate lyase; Region: Alginate_lyase2; pfam08787 264730010220 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 264730010221 Fusaric acid resistance protein family; Region: FUSC; pfam04632 264730010222 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264730010223 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 264730010224 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 264730010225 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730010226 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730010227 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264730010228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 264730010229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264730010230 Ion transport protein; Region: Ion_trans; pfam00520 264730010231 Ion channel; Region: Ion_trans_2; pfam07885 264730010232 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264730010233 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 264730010234 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264730010235 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 264730010236 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 264730010237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730010238 binding surface 264730010239 TPR motif; other site 264730010240 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 264730010241 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 264730010242 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 264730010243 catalytic residues [active] 264730010244 central insert; other site 264730010245 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 264730010246 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 264730010247 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 264730010248 heme exporter protein CcmC; Region: ccmC; TIGR01191 264730010249 heme exporter protein CcmB; Region: ccmB; TIGR01190 264730010250 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 264730010251 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 264730010252 Walker A/P-loop; other site 264730010253 ATP binding site [chemical binding]; other site 264730010254 Q-loop/lid; other site 264730010255 ABC transporter signature motif; other site 264730010256 Walker B; other site 264730010257 D-loop; other site 264730010258 H-loop/switch region; other site 264730010259 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 264730010260 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 264730010261 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 264730010262 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 264730010263 recombination protein RecR; Reviewed; Region: recR; PRK00076 264730010264 RecR protein; Region: RecR; pfam02132 264730010265 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 264730010266 putative active site [active] 264730010267 putative metal-binding site [ion binding]; other site 264730010268 tetramer interface [polypeptide binding]; other site 264730010269 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 264730010270 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 264730010271 dimer interface [polypeptide binding]; other site 264730010272 active site 264730010273 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264730010274 substrate binding site [chemical binding]; other site 264730010275 catalytic residue [active] 264730010276 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264730010277 homotrimer interaction site [polypeptide binding]; other site 264730010278 putative active site [active] 264730010279 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264730010280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730010281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264730010282 Coenzyme A binding pocket [chemical binding]; other site 264730010283 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264730010284 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264730010285 NAD binding site [chemical binding]; other site 264730010286 catalytic residues [active] 264730010287 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 264730010288 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 264730010289 aconitate hydratase; Validated; Region: PRK09277 264730010290 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 264730010291 substrate binding site [chemical binding]; other site 264730010292 ligand binding site [chemical binding]; other site 264730010293 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 264730010294 substrate binding site [chemical binding]; other site 264730010295 PAS domain; Region: PAS_9; pfam13426 264730010296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730010297 putative active site [active] 264730010298 heme pocket [chemical binding]; other site 264730010299 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730010300 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730010301 dimer interface [polypeptide binding]; other site 264730010302 putative CheW interface [polypeptide binding]; other site 264730010303 Transposase domain (DUF772); Region: DUF772; pfam05598 264730010304 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 264730010305 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264730010306 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730010307 MULE transposase domain; Region: MULE; pfam10551 264730010308 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 264730010309 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 264730010310 Autotransporter beta-domain; Region: Autotransporter; pfam03797 264730010311 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 264730010312 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 264730010313 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 264730010314 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 264730010315 Low-spin heme binding site [chemical binding]; other site 264730010316 Putative water exit pathway; other site 264730010317 Binuclear center (active site) [active] 264730010318 Putative proton exit pathway; other site 264730010319 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 264730010320 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 264730010321 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 264730010322 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 264730010323 Cytochrome c; Region: Cytochrom_C; pfam00034 264730010324 Cytochrome c; Region: Cytochrom_C; pfam00034 264730010325 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264730010326 Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the...; Region: VMO-I; cd00220 264730010327 putative carbohydrate binding site [chemical binding]; other site 264730010328 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 264730010329 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 264730010330 oligomeric interface; other site 264730010331 putative active site [active] 264730010332 homodimer interface [polypeptide binding]; other site 264730010333 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 264730010334 4Fe-4S binding domain; Region: Fer4_5; pfam12801 264730010335 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 264730010336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 264730010337 FixH; Region: FixH; pfam05751 264730010338 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 264730010339 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264730010340 Heavy-metal-associated domain; Region: HMA; pfam00403 264730010341 metal-binding site [ion binding] 264730010342 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264730010343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730010344 motif II; other site 264730010345 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 264730010346 Uncharacterized conserved protein [Function unknown]; Region: COG2836 264730010347 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 264730010348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730010349 FeS/SAM binding site; other site 264730010350 HemN C-terminal domain; Region: HemN_C; pfam06969 264730010351 molecular chaperone DnaK; Provisional; Region: PRK13411 264730010352 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 264730010353 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264730010354 ligand binding site [chemical binding]; other site 264730010355 flexible hinge region; other site 264730010356 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264730010357 putative switch regulator; other site 264730010358 non-specific DNA interactions [nucleotide binding]; other site 264730010359 DNA binding site [nucleotide binding] 264730010360 sequence specific DNA binding site [nucleotide binding]; other site 264730010361 putative cAMP binding site [chemical binding]; other site 264730010362 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264730010363 active site 264730010364 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 264730010365 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 264730010366 putative CheA interaction surface; other site 264730010367 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 264730010368 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264730010369 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264730010370 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264730010371 Magnesium ion binding site [ion binding]; other site 264730010372 flagellar motor protein MotD; Reviewed; Region: PRK09038 264730010373 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 264730010374 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730010375 ligand binding site [chemical binding]; other site 264730010376 flagellar motor protein; Reviewed; Region: motC; PRK09109 264730010377 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 264730010378 Response regulator receiver domain; Region: Response_reg; pfam00072 264730010379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010380 active site 264730010381 phosphorylation site [posttranslational modification] 264730010382 intermolecular recognition site; other site 264730010383 dimerization interface [polypeptide binding]; other site 264730010384 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 264730010385 CheB methylesterase; Region: CheB_methylest; pfam01339 264730010386 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264730010387 putative binding surface; other site 264730010388 active site 264730010389 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 264730010390 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 264730010391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730010392 ATP binding site [chemical binding]; other site 264730010393 Mg2+ binding site [ion binding]; other site 264730010394 G-X-G motif; other site 264730010395 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 264730010396 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 264730010397 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 264730010398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010399 active site 264730010400 phosphorylation site [posttranslational modification] 264730010401 intermolecular recognition site; other site 264730010402 dimerization interface [polypeptide binding]; other site 264730010403 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 264730010404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730010405 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264730010406 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730010407 DNA binding residues [nucleotide binding] 264730010408 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 264730010409 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264730010410 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264730010411 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 264730010412 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 264730010413 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264730010414 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 264730010415 FHIPEP family; Region: FHIPEP; pfam00771 264730010416 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 264730010417 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 264730010418 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 264730010419 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 264730010420 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 264730010421 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 264730010422 flagellar motor switch protein; Validated; Region: fliN; PRK05698 264730010423 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 264730010424 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 264730010425 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 264730010426 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 264730010427 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 264730010428 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264730010429 putative binding surface; other site 264730010430 active site 264730010431 Response regulator receiver domain; Region: Response_reg; pfam00072 264730010432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010433 active site 264730010434 phosphorylation site [posttranslational modification] 264730010435 intermolecular recognition site; other site 264730010436 dimerization interface [polypeptide binding]; other site 264730010437 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264730010438 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264730010439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264730010440 ATP binding site [chemical binding]; other site 264730010441 Mg2+ binding site [ion binding]; other site 264730010442 G-X-G motif; other site 264730010443 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264730010444 anti sigma factor interaction site; other site 264730010445 regulatory phosphorylation site [posttranslational modification]; other site 264730010446 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 264730010447 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 264730010448 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 264730010449 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 264730010450 Walker A motif/ATP binding site; other site 264730010451 Walker B motif; other site 264730010452 flagellar assembly protein H; Validated; Region: fliH; PRK05687 264730010453 Flagellar assembly protein FliH; Region: FliH; pfam02108 264730010454 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 264730010455 MgtE intracellular N domain; Region: MgtE_N; cl15244 264730010456 FliG C-terminal domain; Region: FliG_C; pfam01706 264730010457 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 264730010458 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 264730010459 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 264730010460 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 264730010461 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264730010462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010463 active site 264730010464 phosphorylation site [posttranslational modification] 264730010465 intermolecular recognition site; other site 264730010466 dimerization interface [polypeptide binding]; other site 264730010467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730010468 Walker A motif; other site 264730010469 ATP binding site [chemical binding]; other site 264730010470 Walker B motif; other site 264730010471 arginine finger; other site 264730010472 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 264730010473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730010474 dimer interface [polypeptide binding]; other site 264730010475 phosphorylation site [posttranslational modification] 264730010476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730010477 ATP binding site [chemical binding]; other site 264730010478 Mg2+ binding site [ion binding]; other site 264730010479 G-X-G motif; other site 264730010480 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264730010481 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 264730010482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730010483 Walker A motif; other site 264730010484 ATP binding site [chemical binding]; other site 264730010485 Walker B motif; other site 264730010486 arginine finger; other site 264730010487 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730010488 flagellar protein FliS; Validated; Region: fliS; PRK05685 264730010489 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 264730010490 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 264730010491 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 264730010492 FlaG protein; Region: FlaG; pfam03646 264730010493 flagellin; Provisional; Region: PRK12802 264730010494 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264730010495 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264730010496 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264730010497 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 264730010498 dimer interface [polypeptide binding]; other site 264730010499 active site 264730010500 CoA binding pocket [chemical binding]; other site 264730010501 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264730010502 active site 264730010503 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730010504 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264730010505 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264730010506 Probable Catalytic site; other site 264730010507 metal-binding site 264730010508 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264730010509 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264730010510 active site 264730010511 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730010512 active site 264730010513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730010514 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 264730010515 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264730010516 Probable Catalytic site; other site 264730010517 metal-binding site 264730010518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730010519 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 264730010520 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717 264730010521 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264730010522 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 264730010523 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264730010524 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 264730010525 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 264730010526 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 264730010527 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 264730010528 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 264730010529 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 264730010530 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 264730010531 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 264730010532 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264730010533 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264730010534 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 264730010535 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264730010536 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 264730010537 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 264730010538 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264730010539 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 264730010540 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 264730010541 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264730010542 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 264730010543 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264730010544 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 264730010545 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264730010546 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 264730010547 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 264730010548 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 264730010549 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 264730010550 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264730010551 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264730010552 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 264730010553 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 264730010554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 264730010555 SnoaL-like domain; Region: SnoaL_2; pfam12680 264730010556 cyanate hydratase; Validated; Region: PRK02866 264730010557 Helix-turn-helix domain; Region: HTH_31; pfam13560 264730010558 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 264730010559 oligomer interface [polypeptide binding]; other site 264730010560 active site 264730010561 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 264730010562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730010563 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 264730010564 dimerization interface [polypeptide binding]; other site 264730010565 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 264730010566 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264730010567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730010568 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 264730010569 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730010570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010571 active site 264730010572 phosphorylation site [posttranslational modification] 264730010573 intermolecular recognition site; other site 264730010574 dimerization interface [polypeptide binding]; other site 264730010575 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 264730010576 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 264730010577 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 264730010578 FlgN protein; Region: FlgN; pfam05130 264730010579 Flagellar regulator YcgR; Region: YcgR; pfam07317 264730010580 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 264730010581 PilZ domain; Region: PilZ; pfam07238 264730010582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730010583 putative substrate translocation pore; other site 264730010584 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730010585 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 264730010586 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264730010587 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 264730010588 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264730010589 inhibitor-cofactor binding pocket; inhibition site 264730010590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730010591 catalytic residue [active] 264730010592 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264730010593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730010594 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264730010595 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264730010596 active site 264730010597 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264730010598 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264730010599 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264730010600 Probable Catalytic site; other site 264730010601 metal-binding site 264730010602 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730010603 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 264730010604 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 264730010605 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264730010606 dimer interface [polypeptide binding]; other site 264730010607 active site 264730010608 CoA binding pocket [chemical binding]; other site 264730010609 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 264730010610 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 264730010611 putative trimer interface [polypeptide binding]; other site 264730010612 putative CoA binding site [chemical binding]; other site 264730010613 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264730010614 classical (c) SDRs; Region: SDR_c; cd05233 264730010615 NAD(P) binding site [chemical binding]; other site 264730010616 active site 264730010617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730010618 ATP binding site [chemical binding]; other site 264730010619 Mg2+ binding site [ion binding]; other site 264730010620 G-X-G motif; other site 264730010621 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 264730010622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010623 active site 264730010624 phosphorylation site [posttranslational modification] 264730010625 intermolecular recognition site; other site 264730010626 dimerization interface [polypeptide binding]; other site 264730010627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730010628 binding surface 264730010629 TPR motif; other site 264730010630 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264730010631 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 264730010632 Bacterial SH3 domain; Region: SH3_3; pfam08239 264730010633 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 264730010634 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 264730010635 Cupin domain; Region: Cupin_2; cl17218 264730010636 Helix-turn-helix domain; Region: HTH_18; pfam12833 264730010637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730010638 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 264730010639 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264730010640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 264730010641 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 264730010642 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 264730010643 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 264730010644 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 264730010645 Na binding site [ion binding]; other site 264730010646 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 264730010647 BNR repeat-like domain; Region: BNR_2; pfam13088 264730010648 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264730010649 classical (c) SDRs; Region: SDR_c; cd05233 264730010650 NAD(P) binding site [chemical binding]; other site 264730010651 active site 264730010652 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264730010653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730010654 putative DNA binding site [nucleotide binding]; other site 264730010655 putative Zn2+ binding site [ion binding]; other site 264730010656 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264730010657 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730010658 MULE transposase domain; Region: MULE; pfam10551 264730010659 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 264730010660 GAF domain; Region: GAF; pfam01590 264730010661 Phytochrome region; Region: PHY; pfam00360 264730010662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730010663 dimer interface [polypeptide binding]; other site 264730010664 phosphorylation site [posttranslational modification] 264730010665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730010666 ATP binding site [chemical binding]; other site 264730010667 Mg2+ binding site [ion binding]; other site 264730010668 G-X-G motif; other site 264730010669 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 264730010670 heme binding pocket [chemical binding]; other site 264730010671 heme ligand [chemical binding]; other site 264730010672 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 264730010673 Sulfatase; Region: Sulfatase; pfam00884 264730010674 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 264730010675 BNR repeat-like domain; Region: BNR_2; pfam13088 264730010676 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 264730010677 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 264730010678 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 264730010679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010680 active site 264730010681 phosphorylation site [posttranslational modification] 264730010682 intermolecular recognition site; other site 264730010683 dimerization interface [polypeptide binding]; other site 264730010684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730010685 DNA binding site [nucleotide binding] 264730010686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730010687 HAMP domain; Region: HAMP; pfam00672 264730010688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730010689 dimer interface [polypeptide binding]; other site 264730010690 phosphorylation site [posttranslational modification] 264730010691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730010692 ATP binding site [chemical binding]; other site 264730010693 Mg2+ binding site [ion binding]; other site 264730010694 G-X-G motif; other site 264730010695 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264730010696 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264730010697 aldehyde dehydrogenase family 7 member; Region: PLN02315 264730010698 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 264730010699 tetrameric interface [polypeptide binding]; other site 264730010700 NAD binding site [chemical binding]; other site 264730010701 catalytic residues [active] 264730010702 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 264730010703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 264730010704 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 264730010705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730010706 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264730010707 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264730010708 dimerization interface [polypeptide binding]; other site 264730010709 substrate binding pocket [chemical binding]; other site 264730010710 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 264730010711 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 264730010712 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 264730010713 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264730010714 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264730010715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730010716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730010717 dimerization interface [polypeptide binding]; other site 264730010718 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264730010719 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264730010720 metal binding site [ion binding]; metal-binding site 264730010721 putative dimer interface [polypeptide binding]; other site 264730010722 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264730010723 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264730010724 NAD(P) binding site [chemical binding]; other site 264730010725 catalytic residues [active] 264730010726 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264730010727 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264730010728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730010729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730010730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730010731 dimerization interface [polypeptide binding]; other site 264730010732 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 264730010733 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264730010734 NAD binding site [chemical binding]; other site 264730010735 catalytic Zn binding site [ion binding]; other site 264730010736 structural Zn binding site [ion binding]; other site 264730010737 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264730010738 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730010739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730010740 DNA-binding site [nucleotide binding]; DNA binding site 264730010741 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264730010742 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 264730010743 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 264730010744 Na binding site [ion binding]; other site 264730010745 putative substrate binding site [chemical binding]; other site 264730010746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730010747 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264730010748 putative active site [active] 264730010749 heme pocket [chemical binding]; other site 264730010750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730010751 putative active site [active] 264730010752 heme pocket [chemical binding]; other site 264730010753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730010754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730010755 dimer interface [polypeptide binding]; other site 264730010756 phosphorylation site [posttranslational modification] 264730010757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730010758 ATP binding site [chemical binding]; other site 264730010759 Mg2+ binding site [ion binding]; other site 264730010760 G-X-G motif; other site 264730010761 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264730010762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010763 active site 264730010764 phosphorylation site [posttranslational modification] 264730010765 intermolecular recognition site; other site 264730010766 dimerization interface [polypeptide binding]; other site 264730010767 Cache domain; Region: Cache_1; pfam02743 264730010768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730010769 dimerization interface [polypeptide binding]; other site 264730010770 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730010771 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730010772 dimer interface [polypeptide binding]; other site 264730010773 putative CheW interface [polypeptide binding]; other site 264730010774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730010775 putative CheW interface [polypeptide binding]; other site 264730010776 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264730010777 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730010778 TAP-like protein; Region: Abhydrolase_4; pfam08386 264730010779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730010780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730010781 WHG domain; Region: WHG; pfam13305 264730010782 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264730010783 classical (c) SDRs; Region: SDR_c; cd05233 264730010784 NAD(P) binding site [chemical binding]; other site 264730010785 active site 264730010786 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264730010787 TAP-like protein; Region: Abhydrolase_4; pfam08386 264730010788 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264730010789 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 264730010790 putative NAD(P) binding site [chemical binding]; other site 264730010791 short chain dehydrogenase; Provisional; Region: PRK06179 264730010792 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 264730010793 NADP binding site [chemical binding]; other site 264730010794 active site 264730010795 steroid binding site; other site 264730010796 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264730010797 EamA-like transporter family; Region: EamA; pfam00892 264730010798 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264730010799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730010800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730010801 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264730010802 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 264730010803 putative C-terminal domain interface [polypeptide binding]; other site 264730010804 putative GSH binding site (G-site) [chemical binding]; other site 264730010805 putative dimer interface [polypeptide binding]; other site 264730010806 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 264730010807 N-terminal domain interface [polypeptide binding]; other site 264730010808 dimer interface [polypeptide binding]; other site 264730010809 substrate binding pocket (H-site) [chemical binding]; other site 264730010810 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 264730010811 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 264730010812 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264730010813 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264730010814 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 264730010815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730010816 motif II; other site 264730010817 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730010818 MULE transposase domain; Region: MULE; pfam10551 264730010819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 264730010820 Transposase; Region: DEDD_Tnp_IS110; pfam01548 264730010821 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 264730010822 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 264730010823 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730010824 metal binding site [ion binding]; metal-binding site 264730010825 active site 264730010826 I-site; other site 264730010827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730010828 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 264730010829 AvrPphF-ORF-2; Region: AvrPphF-ORF-2; pfam09143 264730010830 Tir chaperone protein (CesT) family; Region: CesT; cl08444 264730010831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264730010832 Transposase; Region: HTH_Tnp_1; pfam01527 264730010833 Arc-like DNA binding domain; Region: Arc; pfam03869 264730010834 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 264730010835 MgtE intracellular N domain; Region: MgtE_N; smart00924 264730010836 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 264730010837 Divalent cation transporter; Region: MgtE; cl00786 264730010838 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 264730010839 carbon storage regulator; Provisional; Region: PRK01712 264730010840 aspartate kinase; Reviewed; Region: PRK06635 264730010841 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 264730010842 putative nucleotide binding site [chemical binding]; other site 264730010843 putative catalytic residues [active] 264730010844 putative Mg ion binding site [ion binding]; other site 264730010845 putative aspartate binding site [chemical binding]; other site 264730010846 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 264730010847 putative allosteric regulatory site; other site 264730010848 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 264730010849 putative allosteric regulatory residue; other site 264730010850 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 264730010851 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 264730010852 motif 1; other site 264730010853 active site 264730010854 motif 2; other site 264730010855 motif 3; other site 264730010856 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264730010857 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 264730010858 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 264730010859 tetramer interface [polypeptide binding]; other site 264730010860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730010861 catalytic residue [active] 264730010862 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 264730010863 active site 264730010864 homopentamer interface [polypeptide binding]; other site 264730010865 dimer interface [polypeptide binding]; other site 264730010866 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 264730010867 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 264730010868 putative active site [active] 264730010869 Zn binding site [ion binding]; other site 264730010870 succinylarginine dihydrolase; Provisional; Region: PRK13281 264730010871 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 264730010872 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 264730010873 NAD(P) binding site [chemical binding]; other site 264730010874 catalytic residues [active] 264730010875 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 264730010876 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 264730010877 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 264730010878 arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245 264730010879 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 264730010880 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730010881 inhibitor-cofactor binding pocket; inhibition site 264730010882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730010883 catalytic residue [active] 264730010884 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264730010885 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 264730010886 conserved cys residue [active] 264730010887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730010888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730010889 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 264730010890 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264730010891 Walker A/P-loop; other site 264730010892 ATP binding site [chemical binding]; other site 264730010893 Q-loop/lid; other site 264730010894 ABC transporter signature motif; other site 264730010895 Walker B; other site 264730010896 D-loop; other site 264730010897 H-loop/switch region; other site 264730010898 Predicted deacylase [General function prediction only]; Region: COG3608 264730010899 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 264730010900 active site 264730010901 Zn binding site [ion binding]; other site 264730010902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730010903 dimer interface [polypeptide binding]; other site 264730010904 conserved gate region; other site 264730010905 putative PBP binding loops; other site 264730010906 ABC-ATPase subunit interface; other site 264730010907 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730010908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730010909 dimer interface [polypeptide binding]; other site 264730010910 conserved gate region; other site 264730010911 putative PBP binding loops; other site 264730010912 ABC-ATPase subunit interface; other site 264730010913 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 264730010914 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730010915 substrate binding pocket [chemical binding]; other site 264730010916 membrane-bound complex binding site; other site 264730010917 hinge residues; other site 264730010918 acetyl-CoA synthetase; Provisional; Region: PRK00174 264730010919 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 264730010920 active site 264730010921 CoA binding site [chemical binding]; other site 264730010922 acyl-activating enzyme (AAE) consensus motif; other site 264730010923 AMP binding site [chemical binding]; other site 264730010924 acetate binding site [chemical binding]; other site 264730010925 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 264730010926 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 264730010927 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 264730010928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730010929 Walker A motif; other site 264730010930 ATP binding site [chemical binding]; other site 264730010931 Walker B motif; other site 264730010932 arginine finger; other site 264730010933 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 264730010934 cofactor binding site; other site 264730010935 metal binding site [ion binding]; metal-binding site 264730010936 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 264730010937 aromatic arch; other site 264730010938 DCoH dimer interaction site [polypeptide binding]; other site 264730010939 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 264730010940 DCoH tetramer interaction site [polypeptide binding]; other site 264730010941 substrate binding site [chemical binding]; other site 264730010942 major facilitator superfamily transporter; Provisional; Region: PRK05122 264730010943 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 264730010944 hypothetical protein; Provisional; Region: PRK09256 264730010945 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 264730010946 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264730010947 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264730010948 RNA binding surface [nucleotide binding]; other site 264730010949 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 264730010950 probable active site [active] 264730010951 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 264730010952 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 264730010953 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 264730010954 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 264730010955 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 264730010956 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 264730010957 active site 264730010958 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 264730010959 intracellular septation protein A; Reviewed; Region: PRK00259 264730010960 YciI-like protein; Reviewed; Region: PRK11370 264730010961 SH3 domain-containing protein; Provisional; Region: PRK10884 264730010962 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264730010963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730010964 active site 264730010965 phosphorylation site [posttranslational modification] 264730010966 intermolecular recognition site; other site 264730010967 dimerization interface [polypeptide binding]; other site 264730010968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730010969 DNA binding site [nucleotide binding] 264730010970 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 264730010971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730010972 HAMP domain; Region: HAMP; pfam00672 264730010973 dimerization interface [polypeptide binding]; other site 264730010974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730010975 ATP binding site [chemical binding]; other site 264730010976 G-X-G motif; other site 264730010977 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 264730010978 putative FMN binding site [chemical binding]; other site 264730010979 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 264730010980 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 264730010981 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264730010982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730010983 putative substrate translocation pore; other site 264730010984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730010985 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 264730010986 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730010987 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730010988 MarR family; Region: MarR_2; cl17246 264730010989 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264730010990 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 264730010991 active site 264730010992 dinuclear metal binding site [ion binding]; other site 264730010993 dimerization interface [polypeptide binding]; other site 264730010994 Predicted Fe-S protein [General function prediction only]; Region: COG3313 264730010995 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 264730010996 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 264730010997 substrate binding site [chemical binding]; other site 264730010998 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 264730010999 substrate binding site [chemical binding]; other site 264730011000 ligand binding site [chemical binding]; other site 264730011001 hypothetical protein; Provisional; Region: PRK11469 264730011002 Domain of unknown function DUF; Region: DUF204; pfam02659 264730011003 Domain of unknown function DUF; Region: DUF204; pfam02659 264730011004 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 264730011005 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264730011006 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264730011007 active site 264730011008 MoxR-like ATPases [General function prediction only]; Region: COG0714 264730011009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730011010 Walker A motif; other site 264730011011 ATP binding site [chemical binding]; other site 264730011012 Walker B motif; other site 264730011013 arginine finger; other site 264730011014 Protein of unknown function DUF58; Region: DUF58; pfam01882 264730011015 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 264730011016 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 264730011017 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 264730011018 metal ion-dependent adhesion site (MIDAS); other site 264730011019 von Willebrand factor type A domain; Region: VWA_2; pfam13519 264730011020 metal ion-dependent adhesion site (MIDAS); other site 264730011021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730011022 TPR motif; other site 264730011023 TPR repeat; Region: TPR_11; pfam13414 264730011024 binding surface 264730011025 Oxygen tolerance; Region: BatD; pfam13584 264730011026 exonuclease subunit SbcD; Provisional; Region: PRK10966 264730011027 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 264730011028 active site 264730011029 metal binding site [ion binding]; metal-binding site 264730011030 DNA binding site [nucleotide binding] 264730011031 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 264730011032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730011033 AAA domain; Region: AAA_23; pfam13476 264730011034 Walker A/P-loop; other site 264730011035 ATP binding site [chemical binding]; other site 264730011036 Q-loop/lid; other site 264730011037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730011038 ABC transporter signature motif; other site 264730011039 Walker B; other site 264730011040 D-loop; other site 264730011041 H-loop/switch region; other site 264730011042 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 264730011043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 264730011044 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264730011045 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 264730011046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730011047 putative substrate translocation pore; other site 264730011048 dihydroxy-acid dehydratase; Validated; Region: PRK06131 264730011049 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730011050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730011051 DNA-binding site [nucleotide binding]; DNA binding site 264730011052 FCD domain; Region: FCD; pfam07729 264730011053 PAAR motif; Region: PAAR_motif; pfam05488 264730011054 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730011055 MULE transposase domain; Region: MULE; pfam10551 264730011056 Transposase domain (DUF772); Region: DUF772; pfam05598 264730011057 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 264730011058 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264730011059 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730011060 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730011061 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730011062 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 264730011063 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 264730011064 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264730011065 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 264730011066 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 264730011067 Predicted membrane protein [Function unknown]; Region: COG3766 264730011068 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 264730011069 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 264730011070 Rhomboid family; Region: Rhomboid; cl11446 264730011071 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 264730011072 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 264730011073 aminopeptidase N; Provisional; Region: pepN; PRK14015 264730011074 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 264730011075 active site 264730011076 Zn binding site [ion binding]; other site 264730011077 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 264730011078 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 264730011079 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 264730011080 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264730011081 active site 264730011082 metal binding site [ion binding]; metal-binding site 264730011083 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 264730011084 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 264730011085 PAAR motif; Region: PAAR_motif; pfam05488 264730011086 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 264730011087 arsenical pump membrane protein; Provisional; Region: PRK15445 264730011088 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 264730011089 transmembrane helices; other site 264730011090 Protein of unknown function (DUF962); Region: DUF962; pfam06127 264730011091 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264730011092 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264730011093 putative active site [active] 264730011094 putative metal binding site [ion binding]; other site 264730011095 Rdx family; Region: Rdx; cl01407 264730011096 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264730011097 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264730011098 Walker A/P-loop; other site 264730011099 ATP binding site [chemical binding]; other site 264730011100 Q-loop/lid; other site 264730011101 ABC transporter signature motif; other site 264730011102 Walker B; other site 264730011103 D-loop; other site 264730011104 H-loop/switch region; other site 264730011105 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264730011106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730011107 dimer interface [polypeptide binding]; other site 264730011108 conserved gate region; other site 264730011109 putative PBP binding loops; other site 264730011110 ABC-ATPase subunit interface; other site 264730011111 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264730011112 active site 264730011113 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 264730011114 dimer interface [polypeptide binding]; other site 264730011115 non-prolyl cis peptide bond; other site 264730011116 insertion regions; other site 264730011117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730011118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730011119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264730011120 dimerization interface [polypeptide binding]; other site 264730011121 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 264730011122 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 264730011123 active site residue [active] 264730011124 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 264730011125 active site residue [active] 264730011126 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 264730011127 active site residue [active] 264730011128 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 264730011129 active site residue [active] 264730011130 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264730011131 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730011132 substrate binding pocket [chemical binding]; other site 264730011133 membrane-bound complex binding site; other site 264730011134 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264730011135 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264730011136 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 264730011137 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 264730011138 molybdopterin cofactor binding site [chemical binding]; other site 264730011139 substrate binding site [chemical binding]; other site 264730011140 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 264730011141 molybdopterin cofactor binding site; other site 264730011142 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264730011143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730011144 substrate binding pocket [chemical binding]; other site 264730011145 membrane-bound complex binding site; other site 264730011146 hinge residues; other site 264730011147 LysR family transcriptional regulator; Provisional; Region: PRK14997 264730011148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730011149 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264730011150 putative effector binding pocket; other site 264730011151 dimerization interface [polypeptide binding]; other site 264730011152 Pirin-related protein [General function prediction only]; Region: COG1741 264730011153 Pirin; Region: Pirin; pfam02678 264730011154 Cupin domain; Region: Cupin_2; cl17218 264730011155 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 264730011156 GAF domain; Region: GAF_2; pfam13185 264730011157 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 264730011158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730011159 Walker A motif; other site 264730011160 ATP binding site [chemical binding]; other site 264730011161 Walker B motif; other site 264730011162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730011163 dimer interface [polypeptide binding]; other site 264730011164 phosphorylation site [posttranslational modification] 264730011165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730011166 ATP binding site [chemical binding]; other site 264730011167 Mg2+ binding site [ion binding]; other site 264730011168 G-X-G motif; other site 264730011169 Response regulator receiver domain; Region: Response_reg; pfam00072 264730011170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730011171 active site 264730011172 phosphorylation site [posttranslational modification] 264730011173 intermolecular recognition site; other site 264730011174 dimerization interface [polypeptide binding]; other site 264730011175 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264730011176 catalytic residues [active] 264730011177 dimer interface [polypeptide binding]; other site 264730011178 methionine sulfoxide reductase B; Provisional; Region: PRK00222 264730011179 SelR domain; Region: SelR; pfam01641 264730011180 aminotransferase AlaT; Validated; Region: PRK09265 264730011181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730011182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730011183 homodimer interface [polypeptide binding]; other site 264730011184 catalytic residue [active] 264730011185 heat shock protein HtpX; Provisional; Region: PRK05457 264730011186 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 264730011187 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 264730011188 putative active site [active] 264730011189 metal binding site [ion binding]; metal-binding site 264730011190 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 264730011191 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264730011192 ATP binding site [chemical binding]; other site 264730011193 Mg++ binding site [ion binding]; other site 264730011194 motif III; other site 264730011195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730011196 nucleotide binding region [chemical binding]; other site 264730011197 ATP-binding site [chemical binding]; other site 264730011198 DbpA RNA binding domain; Region: DbpA; pfam03880 264730011199 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 264730011200 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 264730011201 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 264730011202 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 264730011203 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730011204 MULE transposase domain; Region: MULE; pfam10551 264730011205 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264730011206 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 264730011207 putative ADP-binding pocket [chemical binding]; other site 264730011208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730011209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730011210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730011211 dimerization interface [polypeptide binding]; other site 264730011212 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264730011213 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264730011214 MarR family; Region: MarR; pfam01047 264730011215 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 264730011216 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264730011217 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264730011218 substrate binding pocket [chemical binding]; other site 264730011219 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264730011220 elongation factor P; Validated; Region: PRK00529 264730011221 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 264730011222 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264730011223 RNA binding site [nucleotide binding]; other site 264730011224 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 264730011225 RNA binding site [nucleotide binding]; other site 264730011226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 264730011227 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 264730011228 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264730011229 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 264730011230 serine transporter; Region: stp; TIGR00814 264730011231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730011232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730011233 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 264730011234 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 264730011235 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 264730011236 NAD(P) binding site [chemical binding]; other site 264730011237 homodimer interface [polypeptide binding]; other site 264730011238 substrate binding site [chemical binding]; other site 264730011239 active site 264730011240 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 264730011241 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 264730011242 Mg++ binding site [ion binding]; other site 264730011243 putative catalytic motif [active] 264730011244 putative substrate binding site [chemical binding]; other site 264730011245 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264730011246 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 264730011247 putative NAD(P) binding site [chemical binding]; other site 264730011248 active site 264730011249 putative substrate binding site [chemical binding]; other site 264730011250 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 264730011251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 264730011252 Beta-Casp domain; Region: Beta-Casp; smart01027 264730011253 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 264730011254 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264730011255 IHF dimer interface [polypeptide binding]; other site 264730011256 IHF - DNA interface [nucleotide binding]; other site 264730011257 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 264730011258 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 264730011259 RNA binding site [nucleotide binding]; other site 264730011260 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 264730011261 RNA binding site [nucleotide binding]; other site 264730011262 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 264730011263 RNA binding site [nucleotide binding]; other site 264730011264 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264730011265 RNA binding site [nucleotide binding]; other site 264730011266 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264730011267 RNA binding site [nucleotide binding]; other site 264730011268 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 264730011269 RNA binding site [nucleotide binding]; other site 264730011270 cytidylate kinase; Provisional; Region: cmk; PRK00023 264730011271 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 264730011272 CMP-binding site; other site 264730011273 The sites determining sugar specificity; other site 264730011274 prephenate dehydrogenase; Validated; Region: PRK08507 264730011275 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 264730011276 putative active site [active] 264730011277 Chorismate mutase type II; Region: CM_2; cl00693 264730011278 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 264730011279 Prephenate dehydratase; Region: PDT; pfam00800 264730011280 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 264730011281 putative L-Phe binding site [chemical binding]; other site 264730011282 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 264730011283 homodimer interface [polypeptide binding]; other site 264730011284 substrate-cofactor binding pocket; other site 264730011285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730011286 catalytic residue [active] 264730011287 DNA gyrase subunit A; Validated; Region: PRK05560 264730011288 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 264730011289 CAP-like domain; other site 264730011290 active site 264730011291 primary dimer interface [polypeptide binding]; other site 264730011292 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264730011293 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264730011294 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264730011295 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264730011296 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264730011297 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264730011298 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 264730011299 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 264730011300 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 264730011301 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 264730011302 active site 264730011303 putative substrate binding pocket [chemical binding]; other site 264730011304 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 264730011305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730011306 S-adenosylmethionine binding site [chemical binding]; other site 264730011307 phosphoglycolate phosphatase; Provisional; Region: PRK13222 264730011308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730011309 motif II; other site 264730011310 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 264730011311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730011312 NAD(P) binding site [chemical binding]; other site 264730011313 active site 264730011314 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730011315 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730011316 metal binding site [ion binding]; metal-binding site 264730011317 active site 264730011318 I-site; other site 264730011319 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 264730011320 PAS fold; Region: PAS; pfam00989 264730011321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730011322 putative active site [active] 264730011323 heme pocket [chemical binding]; other site 264730011324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730011325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730011326 metal binding site [ion binding]; metal-binding site 264730011327 active site 264730011328 I-site; other site 264730011329 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730011330 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264730011331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730011332 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 264730011333 Walker A/P-loop; other site 264730011334 ATP binding site [chemical binding]; other site 264730011335 Q-loop/lid; other site 264730011336 ABC transporter signature motif; other site 264730011337 Walker B; other site 264730011338 D-loop; other site 264730011339 H-loop/switch region; other site 264730011340 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 264730011341 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 264730011342 catalytic residues [active] 264730011343 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 264730011344 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 264730011345 active site residue [active] 264730011346 BolA-like protein; Region: BolA; cl00386 264730011347 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 264730011348 fumarate hydratase; Provisional; Region: PRK12425 264730011349 Class II fumarases; Region: Fumarase_classII; cd01362 264730011350 active site 264730011351 tetramer interface [polypeptide binding]; other site 264730011352 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 264730011353 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264730011354 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264730011355 EamA-like transporter family; Region: EamA; pfam00892 264730011356 DTW domain; Region: DTW; cl01221 264730011357 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 264730011358 RmuC family; Region: RmuC; pfam02646 264730011359 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 264730011360 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264730011361 catalytic residues [active] 264730011362 dimer interface [polypeptide binding]; other site 264730011363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730011364 cobalamin synthase; Reviewed; Region: cobS; PRK00235 264730011365 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264730011366 catalytic core [active] 264730011367 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 264730011368 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 264730011369 putative dimer interface [polypeptide binding]; other site 264730011370 active site pocket [active] 264730011371 putative cataytic base [active] 264730011372 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 264730011373 homotrimer interface [polypeptide binding]; other site 264730011374 Walker A motif; other site 264730011375 GTP binding site [chemical binding]; other site 264730011376 Walker B motif; other site 264730011377 cobyric acid synthase; Provisional; Region: PRK00784 264730011378 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 264730011379 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 264730011380 catalytic triad [active] 264730011381 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 264730011382 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730011383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730011384 homodimer interface [polypeptide binding]; other site 264730011385 catalytic residue [active] 264730011386 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 264730011387 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 264730011388 putative FMN binding site [chemical binding]; other site 264730011389 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 264730011390 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264730011391 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 264730011392 catalytic triad [active] 264730011393 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 264730011394 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 264730011395 Walker A motif; other site 264730011396 homodimer interface [polypeptide binding]; other site 264730011397 ATP binding site [chemical binding]; other site 264730011398 hydroxycobalamin binding site [chemical binding]; other site 264730011399 Walker B motif; other site 264730011400 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 264730011401 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 264730011402 NlpC/P60 family; Region: NLPC_P60; pfam00877 264730011403 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 264730011404 NlpC/P60 family; Region: NLPC_P60; pfam00877 264730011405 NAD-dependent deacetylase; Provisional; Region: PRK00481 264730011406 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 264730011407 NAD+ binding site [chemical binding]; other site 264730011408 substrate binding site [chemical binding]; other site 264730011409 Zn binding site [ion binding]; other site 264730011410 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 264730011411 DNA replication initiation factor; Validated; Region: PRK05642 264730011412 Walker A motif; other site 264730011413 ATP binding site [chemical binding]; other site 264730011414 Walker B motif; other site 264730011415 arginine finger; other site 264730011416 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 264730011417 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264730011418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249 264730011419 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 264730011420 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 264730011421 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 264730011422 dimerization interface [polypeptide binding]; other site 264730011423 putative ATP binding site [chemical binding]; other site 264730011424 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 264730011425 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 264730011426 active site 264730011427 substrate binding site [chemical binding]; other site 264730011428 cosubstrate binding site; other site 264730011429 catalytic site [active] 264730011430 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 264730011431 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 264730011432 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 264730011433 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 264730011434 homodimer interface [polypeptide binding]; other site 264730011435 metal binding site [ion binding]; metal-binding site 264730011436 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 264730011437 homodimer interface [polypeptide binding]; other site 264730011438 active site 264730011439 putative chemical substrate binding site [chemical binding]; other site 264730011440 metal binding site [ion binding]; metal-binding site 264730011441 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264730011442 HD domain; Region: HD_4; pfam13328 264730011443 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264730011444 synthetase active site [active] 264730011445 NTP binding site [chemical binding]; other site 264730011446 metal binding site [ion binding]; metal-binding site 264730011447 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264730011448 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264730011449 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 264730011450 TRAM domain; Region: TRAM; pfam01938 264730011451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730011452 S-adenosylmethionine binding site [chemical binding]; other site 264730011453 cysteine synthase B; Region: cysM; TIGR01138 264730011454 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264730011455 dimer interface [polypeptide binding]; other site 264730011456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730011457 catalytic residue [active] 264730011458 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 264730011459 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730011460 dimerization interface [polypeptide binding]; other site 264730011461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730011462 dimer interface [polypeptide binding]; other site 264730011463 phosphorylation site [posttranslational modification] 264730011464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730011465 ATP binding site [chemical binding]; other site 264730011466 Mg2+ binding site [ion binding]; other site 264730011467 G-X-G motif; other site 264730011468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730011469 active site 264730011470 phosphorylation site [posttranslational modification] 264730011471 intermolecular recognition site; other site 264730011472 dimerization interface [polypeptide binding]; other site 264730011473 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264730011474 putative binding surface; other site 264730011475 active site 264730011476 META domain; Region: META; pfam03724 264730011477 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264730011478 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264730011479 catalytic residues [active] 264730011480 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 264730011481 ArsC family; Region: ArsC; pfam03960 264730011482 catalytic residues [active] 264730011483 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264730011484 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264730011485 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 264730011486 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 264730011487 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 264730011488 Ligand Binding Site [chemical binding]; other site 264730011489 hypothetical protein; Provisional; Region: PRK04860 264730011490 SprT homologues; Region: SprT; cl01182 264730011491 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 264730011492 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264730011493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 264730011494 dimer interface [polypeptide binding]; other site 264730011495 phosphorylation site [posttranslational modification] 264730011496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730011497 ATP binding site [chemical binding]; other site 264730011498 Mg2+ binding site [ion binding]; other site 264730011499 G-X-G motif; other site 264730011500 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264730011501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730011502 active site 264730011503 phosphorylation site [posttranslational modification] 264730011504 intermolecular recognition site; other site 264730011505 dimerization interface [polypeptide binding]; other site 264730011506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730011507 DNA binding site [nucleotide binding] 264730011508 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264730011509 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264730011510 Transposase IS200 like; Region: Y1_Tnp; cl00848 264730011511 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 264730011512 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 264730011513 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 264730011514 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 264730011515 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 264730011516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730011517 dimerization interface [polypeptide binding]; other site 264730011518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730011519 dimer interface [polypeptide binding]; other site 264730011520 phosphorylation site [posttranslational modification] 264730011521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730011522 ATP binding site [chemical binding]; other site 264730011523 Mg2+ binding site [ion binding]; other site 264730011524 G-X-G motif; other site 264730011525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264730011526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730011527 active site 264730011528 phosphorylation site [posttranslational modification] 264730011529 intermolecular recognition site; other site 264730011530 dimerization interface [polypeptide binding]; other site 264730011531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730011532 DNA binding site [nucleotide binding] 264730011533 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 264730011534 ATP cone domain; Region: ATP-cone; pfam03477 264730011535 ATP cone domain; Region: ATP-cone; pfam03477 264730011536 Class I ribonucleotide reductase; Region: RNR_I; cd01679 264730011537 active site 264730011538 dimer interface [polypeptide binding]; other site 264730011539 catalytic residues [active] 264730011540 effector binding site; other site 264730011541 R2 peptide binding site; other site 264730011542 putative transposase OrfB; Reviewed; Region: PHA02517 264730011543 HTH-like domain; Region: HTH_21; pfam13276 264730011544 Integrase core domain; Region: rve; pfam00665 264730011545 Integrase core domain; Region: rve_3; pfam13683 264730011546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264730011547 Transposase; Region: HTH_Tnp_1; pfam01527 264730011548 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264730011549 active site 264730011550 catalytic residues [active] 264730011551 Int/Topo IB signature motif; other site 264730011552 DNA binding site [nucleotide binding] 264730011553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 264730011554 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 264730011555 DNA-binding interface [nucleotide binding]; DNA binding site 264730011556 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 264730011557 dimer interface [polypeptide binding]; other site 264730011558 putative radical transfer pathway; other site 264730011559 diiron center [ion binding]; other site 264730011560 tyrosyl radical; other site 264730011561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264730011562 TIGR02391 family protein; Region: hypoth_ymh 264730011563 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730011564 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730011565 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730011566 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 264730011567 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 264730011568 active site 264730011569 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730011570 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 264730011571 acyl-activating enzyme (AAE) consensus motif; other site 264730011572 AMP binding site [chemical binding]; other site 264730011573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730011574 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264730011575 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 264730011576 active site 264730011577 metal binding site [ion binding]; metal-binding site 264730011578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 264730011579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730011580 Coenzyme A binding pocket [chemical binding]; other site 264730011581 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 264730011582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264730011583 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 264730011584 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730011585 inhibitor-cofactor binding pocket; inhibition site 264730011586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730011587 catalytic residue [active] 264730011588 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264730011589 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730011590 catalytic residue [active] 264730011591 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 264730011592 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 264730011593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730011594 motif II; other site 264730011595 RibD C-terminal domain; Region: RibD_C; cl17279 264730011596 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 264730011597 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264730011598 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264730011599 NAD(P) binding site [chemical binding]; other site 264730011600 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 264730011601 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264730011602 active site 264730011603 catalytic residues [active] 264730011604 DNA binding site [nucleotide binding] 264730011605 Int/Topo IB signature motif; other site 264730011606 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 264730011607 Ligand Binding Site [chemical binding]; other site 264730011608 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 264730011609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730011610 FeS/SAM binding site; other site 264730011611 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264730011612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730011613 binding surface 264730011614 TPR motif; other site 264730011615 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264730011616 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730011617 ligand binding site [chemical binding]; other site 264730011618 translocation protein TolB; Provisional; Region: tolB; PRK00178 264730011619 TolB amino-terminal domain; Region: TolB_N; pfam04052 264730011620 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264730011621 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264730011622 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264730011623 TolA protein; Region: tolA_full; TIGR02794 264730011624 TolA protein; Region: tolA_full; TIGR02794 264730011625 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 264730011626 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264730011627 TolR protein; Region: tolR; TIGR02801 264730011628 TolQ protein; Region: tolQ; TIGR02796 264730011629 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264730011630 active site 264730011631 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 264730011632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730011633 Walker A motif; other site 264730011634 ATP binding site [chemical binding]; other site 264730011635 Walker B motif; other site 264730011636 arginine finger; other site 264730011637 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 264730011638 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 264730011639 RuvA N terminal domain; Region: RuvA_N; pfam01330 264730011640 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 264730011641 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 264730011642 active site 264730011643 putative DNA-binding cleft [nucleotide binding]; other site 264730011644 dimer interface [polypeptide binding]; other site 264730011645 hypothetical protein; Validated; Region: PRK00110 264730011646 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 264730011647 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 264730011648 dimer interface [polypeptide binding]; other site 264730011649 anticodon binding site; other site 264730011650 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 264730011651 homodimer interface [polypeptide binding]; other site 264730011652 motif 1; other site 264730011653 active site 264730011654 motif 2; other site 264730011655 GAD domain; Region: GAD; pfam02938 264730011656 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 264730011657 active site 264730011658 motif 3; other site 264730011659 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 264730011660 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 264730011661 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 264730011662 dimerization interface [polypeptide binding]; other site 264730011663 DPS ferroxidase diiron center [ion binding]; other site 264730011664 ion pore; other site 264730011665 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264730011666 DNA-binding site [nucleotide binding]; DNA binding site 264730011667 RNA-binding motif; other site 264730011668 hypothetical protein; Provisional; Region: PRK00295 264730011669 HIT domain; Region: HIT; pfam01230 264730011670 nucleotide binding site/active site [active] 264730011671 HIT family signature motif; other site 264730011672 catalytic residue [active] 264730011673 outer membrane porin, OprD family; Region: OprD; pfam03573 264730011674 prolyl-tRNA synthetase; Provisional; Region: PRK09194 264730011675 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 264730011676 dimer interface [polypeptide binding]; other site 264730011677 motif 1; other site 264730011678 active site 264730011679 motif 2; other site 264730011680 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 264730011681 putative deacylase active site [active] 264730011682 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 264730011683 active site 264730011684 motif 3; other site 264730011685 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 264730011686 anticodon binding site; other site 264730011687 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 264730011688 active site 264730011689 DNA polymerase IV; Validated; Region: PRK02406 264730011690 DNA binding site [nucleotide binding] 264730011691 Predicted integral membrane protein [Function unknown]; Region: COG0392 264730011692 Uncharacterized conserved protein [Function unknown]; Region: COG2898 264730011693 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 264730011694 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 264730011695 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 264730011696 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 264730011697 potassium uptake protein; Region: kup; TIGR00794 264730011698 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 264730011699 putative heme binding pocket [chemical binding]; other site 264730011700 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 264730011701 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264730011702 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730011703 FeS/SAM binding site; other site 264730011704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264730011705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730011706 Coenzyme A binding pocket [chemical binding]; other site 264730011707 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264730011708 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264730011709 RNA binding surface [nucleotide binding]; other site 264730011710 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 264730011711 active site 264730011712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 264730011713 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 264730011714 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 264730011715 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 264730011716 homodimer interaction site [polypeptide binding]; other site 264730011717 cofactor binding site; other site 264730011718 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264730011719 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 264730011720 FAD binding pocket [chemical binding]; other site 264730011721 FAD binding motif [chemical binding]; other site 264730011722 phosphate binding motif [ion binding]; other site 264730011723 beta-alpha-beta structure motif; other site 264730011724 NAD binding pocket [chemical binding]; other site 264730011725 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 264730011726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730011727 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 264730011728 putative dimerization interface [polypeptide binding]; other site 264730011729 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 264730011730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730011731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730011732 active site 264730011733 phosphorylation site [posttranslational modification] 264730011734 intermolecular recognition site; other site 264730011735 dimerization interface [polypeptide binding]; other site 264730011736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730011737 DNA binding residues [nucleotide binding] 264730011738 dimerization interface [polypeptide binding]; other site 264730011739 Uncharacterized conserved protein [Function unknown]; Region: COG3148 264730011740 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 264730011741 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 264730011742 recombination regulator RecX; Reviewed; Region: recX; PRK00117 264730011743 recombinase A; Provisional; Region: recA; PRK09354 264730011744 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 264730011745 hexamer interface [polypeptide binding]; other site 264730011746 Walker A motif; other site 264730011747 ATP binding site [chemical binding]; other site 264730011748 Walker B motif; other site 264730011749 Competence-damaged protein; Region: CinA; pfam02464 264730011750 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 264730011751 MutS domain I; Region: MutS_I; pfam01624 264730011752 MutS domain II; Region: MutS_II; pfam05188 264730011753 MutS domain III; Region: MutS_III; pfam05192 264730011754 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 264730011755 Walker A/P-loop; other site 264730011756 ATP binding site [chemical binding]; other site 264730011757 Q-loop/lid; other site 264730011758 ABC transporter signature motif; other site 264730011759 Walker B; other site 264730011760 D-loop; other site 264730011761 H-loop/switch region; other site 264730011762 Ferredoxin [Energy production and conversion]; Region: COG1146 264730011763 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 264730011764 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 264730011765 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264730011766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730011767 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264730011768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730011769 DNA binding residues [nucleotide binding] 264730011770 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 264730011771 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264730011772 Peptidase family M23; Region: Peptidase_M23; pfam01551 264730011773 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 264730011774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730011775 S-adenosylmethionine binding site [chemical binding]; other site 264730011776 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 264730011777 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 264730011778 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 264730011779 Permutation of conserved domain; other site 264730011780 active site 264730011781 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 264730011782 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 264730011783 homotrimer interaction site [polypeptide binding]; other site 264730011784 zinc binding site [ion binding]; other site 264730011785 CDP-binding sites; other site 264730011786 S-formylglutathione hydrolase; Region: PLN02442 264730011787 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 264730011788 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 264730011789 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 264730011790 substrate binding site [chemical binding]; other site 264730011791 catalytic Zn binding site [ion binding]; other site 264730011792 NAD binding site [chemical binding]; other site 264730011793 structural Zn binding site [ion binding]; other site 264730011794 dimer interface [polypeptide binding]; other site 264730011795 LysR family transcriptional regulator; Provisional; Region: PRK14997 264730011796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730011797 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 264730011798 putative effector binding pocket; other site 264730011799 putative dimerization interface [polypeptide binding]; other site 264730011800 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 264730011801 substrate binding site; other site 264730011802 dimer interface; other site 264730011803 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 264730011804 Septum formation initiator; Region: DivIC; cl17659 264730011805 enolase; Provisional; Region: eno; PRK00077 264730011806 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 264730011807 dimer interface [polypeptide binding]; other site 264730011808 metal binding site [ion binding]; metal-binding site 264730011809 substrate binding pocket [chemical binding]; other site 264730011810 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 264730011811 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264730011812 CTP synthetase; Validated; Region: pyrG; PRK05380 264730011813 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 264730011814 Catalytic site [active] 264730011815 active site 264730011816 UTP binding site [chemical binding]; other site 264730011817 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 264730011818 active site 264730011819 putative oxyanion hole; other site 264730011820 catalytic triad [active] 264730011821 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 264730011822 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 264730011823 Ligand Binding Site [chemical binding]; other site 264730011824 TilS substrate binding domain; Region: TilS; pfam09179 264730011825 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 264730011826 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 264730011827 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 264730011828 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 264730011829 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 264730011830 putative active site [active] 264730011831 putative PHP Thumb interface [polypeptide binding]; other site 264730011832 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264730011833 generic binding surface II; other site 264730011834 generic binding surface I; other site 264730011835 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 264730011836 RNA/DNA hybrid binding site [nucleotide binding]; other site 264730011837 active site 264730011838 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 264730011839 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 264730011840 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 264730011841 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 264730011842 active site 264730011843 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 264730011844 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 264730011845 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 264730011846 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 264730011847 trimer interface [polypeptide binding]; other site 264730011848 active site 264730011849 UDP-GlcNAc binding site [chemical binding]; other site 264730011850 lipid binding site [chemical binding]; lipid-binding site 264730011851 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 264730011852 periplasmic chaperone; Provisional; Region: PRK10780 264730011853 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 264730011854 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264730011855 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264730011856 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264730011857 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264730011858 Surface antigen; Region: Bac_surface_Ag; pfam01103 264730011859 zinc metallopeptidase RseP; Provisional; Region: PRK10779 264730011860 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264730011861 active site 264730011862 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264730011863 protein binding site [polypeptide binding]; other site 264730011864 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264730011865 protein binding site [polypeptide binding]; other site 264730011866 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264730011867 putative substrate binding region [chemical binding]; other site 264730011868 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 264730011869 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 264730011870 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 264730011871 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 264730011872 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 264730011873 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 264730011874 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 264730011875 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 264730011876 catalytic residue [active] 264730011877 putative FPP diphosphate binding site; other site 264730011878 putative FPP binding hydrophobic cleft; other site 264730011879 dimer interface [polypeptide binding]; other site 264730011880 putative IPP diphosphate binding site; other site 264730011881 ribosome recycling factor; Reviewed; Region: frr; PRK00083 264730011882 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 264730011883 hinge region; other site 264730011884 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 264730011885 putative nucleotide binding site [chemical binding]; other site 264730011886 uridine monophosphate binding site [chemical binding]; other site 264730011887 homohexameric interface [polypeptide binding]; other site 264730011888 elongation factor Ts; Provisional; Region: tsf; PRK09377 264730011889 UBA/TS-N domain; Region: UBA; pfam00627 264730011890 Elongation factor TS; Region: EF_TS; pfam00889 264730011891 Elongation factor TS; Region: EF_TS; pfam00889 264730011892 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 264730011893 rRNA interaction site [nucleotide binding]; other site 264730011894 S8 interaction site; other site 264730011895 putative laminin-1 binding site; other site 264730011896 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264730011897 active site 264730011898 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 264730011899 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264730011900 metal binding triad; other site 264730011901 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264730011902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264730011903 Zn2+ binding site [ion binding]; other site 264730011904 Mg2+ binding site [ion binding]; other site 264730011905 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 264730011906 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 264730011907 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 264730011908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730011909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730011910 homodimer interface [polypeptide binding]; other site 264730011911 catalytic residue [active] 264730011912 Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327 264730011913 active site 264730011914 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 264730011915 ArsC family; Region: ArsC; pfam03960 264730011916 putative catalytic residues [active] 264730011917 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 264730011918 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 264730011919 putative trimer interface [polypeptide binding]; other site 264730011920 putative CoA binding site [chemical binding]; other site 264730011921 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 264730011922 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 264730011923 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730011924 catalytic residue [active] 264730011925 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 264730011926 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 264730011927 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 264730011928 putative ATP binding site [chemical binding]; other site 264730011929 putative substrate interface [chemical binding]; other site 264730011930 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 264730011931 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 264730011932 metal binding site [ion binding]; metal-binding site 264730011933 dimer interface [polypeptide binding]; other site 264730011934 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 264730011935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730011936 S-adenosylmethionine binding site [chemical binding]; other site 264730011937 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 264730011938 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 264730011939 putative acyl-acceptor binding pocket; other site 264730011940 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 264730011941 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 264730011942 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 264730011943 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 264730011944 Protein of unknown function DUF72; Region: DUF72; cl00777 264730011945 putative assembly protein; Region: PHA00350 264730011946 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 264730011947 Glycoprotease family; Region: Peptidase_M22; pfam00814 264730011948 adenylate kinase; Reviewed; Region: adk; PRK00279 264730011949 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 264730011950 AMP-binding site [chemical binding]; other site 264730011951 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 264730011952 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 264730011953 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 264730011954 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 264730011955 CHASE3 domain; Region: CHASE3; cl05000 264730011956 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264730011957 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730011958 ligand binding site [chemical binding]; other site 264730011959 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264730011960 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730011961 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264730011962 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 264730011963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 264730011964 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 264730011965 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 264730011966 dimer interface [polypeptide binding]; other site 264730011967 putative anticodon binding site; other site 264730011968 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 264730011969 motif 1; other site 264730011970 active site 264730011971 motif 2; other site 264730011972 motif 3; other site 264730011973 peptide chain release factor 2; Validated; Region: prfB; PRK00578 264730011974 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264730011975 RF-1 domain; Region: RF-1; pfam00472 264730011976 Response regulator receiver domain; Region: Response_reg; pfam00072 264730011977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730011978 active site 264730011979 phosphorylation site [posttranslational modification] 264730011980 intermolecular recognition site; other site 264730011981 dimerization interface [polypeptide binding]; other site 264730011982 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730011983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730011984 metal binding site [ion binding]; metal-binding site 264730011985 active site 264730011986 I-site; other site 264730011987 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 264730011988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730011989 active site 264730011990 phosphorylation site [posttranslational modification] 264730011991 intermolecular recognition site; other site 264730011992 CheB methylesterase; Region: CheB_methylest; pfam01339 264730011993 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264730011994 putative binding surface; other site 264730011995 active site 264730011996 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 264730011997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730011998 ATP binding site [chemical binding]; other site 264730011999 Mg2+ binding site [ion binding]; other site 264730012000 G-X-G motif; other site 264730012001 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264730012002 Response regulator receiver domain; Region: Response_reg; pfam00072 264730012003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730012004 active site 264730012005 phosphorylation site [posttranslational modification] 264730012006 intermolecular recognition site; other site 264730012007 dimerization interface [polypeptide binding]; other site 264730012008 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 264730012009 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 264730012010 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264730012011 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 264730012012 CheW-like domain; Region: CheW; pfam01584 264730012013 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730012014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730012015 dimerization interface [polypeptide binding]; other site 264730012016 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730012017 dimer interface [polypeptide binding]; other site 264730012018 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 264730012019 putative CheW interface [polypeptide binding]; other site 264730012020 Protein of unknown function (DUF533); Region: DUF533; pfam04391 264730012021 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 264730012022 putative metal binding site [ion binding]; other site 264730012023 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730012024 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730012025 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730012026 argininosuccinate synthase; Provisional; Region: PRK13820 264730012027 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 264730012028 ANP binding site [chemical binding]; other site 264730012029 Substrate Binding Site II [chemical binding]; other site 264730012030 Substrate Binding Site I [chemical binding]; other site 264730012031 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264730012032 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264730012033 ligand binding site [chemical binding]; other site 264730012034 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 264730012035 active site 264730012036 substrate binding pocket [chemical binding]; other site 264730012037 dimer interface [polypeptide binding]; other site 264730012038 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 264730012039 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 264730012040 dimer interface [polypeptide binding]; other site 264730012041 catalytic site [active] 264730012042 putative active site [active] 264730012043 putative substrate binding site [chemical binding]; other site 264730012044 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 264730012045 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 264730012046 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 264730012047 heme binding site [chemical binding]; other site 264730012048 ferroxidase pore; other site 264730012049 ferroxidase diiron center [ion binding]; other site 264730012050 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 264730012051 putative GSH binding site [chemical binding]; other site 264730012052 catalytic residues [active] 264730012053 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264730012054 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 264730012055 putative [Fe4-S4] binding site [ion binding]; other site 264730012056 putative molybdopterin cofactor binding site [chemical binding]; other site 264730012057 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 264730012058 putative molybdopterin cofactor binding site; other site 264730012059 ornithine carbamoyltransferase; Provisional; Region: PRK00779 264730012060 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264730012061 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264730012062 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 264730012063 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 264730012064 Walker A/P-loop; other site 264730012065 ATP binding site [chemical binding]; other site 264730012066 Q-loop/lid; other site 264730012067 ABC transporter signature motif; other site 264730012068 Walker B; other site 264730012069 D-loop; other site 264730012070 H-loop/switch region; other site 264730012071 TOBE domain; Region: TOBE_2; pfam08402 264730012072 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 264730012073 putative deacylase active site [active] 264730012074 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 264730012075 amphipathic channel; other site 264730012076 Asn-Pro-Ala signature motifs; other site 264730012077 glycerol kinase; Provisional; Region: glpK; PRK00047 264730012078 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 264730012079 N- and C-terminal domain interface [polypeptide binding]; other site 264730012080 active site 264730012081 MgATP binding site [chemical binding]; other site 264730012082 catalytic site [active] 264730012083 metal binding site [ion binding]; metal-binding site 264730012084 glycerol binding site [chemical binding]; other site 264730012085 homotetramer interface [polypeptide binding]; other site 264730012086 homodimer interface [polypeptide binding]; other site 264730012087 protein IIAGlc interface [polypeptide binding]; other site 264730012088 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 264730012089 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 264730012090 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264730012091 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 264730012092 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264730012093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730012094 substrate binding pocket [chemical binding]; other site 264730012095 membrane-bound complex binding site; other site 264730012096 hinge residues; other site 264730012097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730012098 dimer interface [polypeptide binding]; other site 264730012099 conserved gate region; other site 264730012100 putative PBP binding loops; other site 264730012101 ABC-ATPase subunit interface; other site 264730012102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730012103 dimer interface [polypeptide binding]; other site 264730012104 conserved gate region; other site 264730012105 putative PBP binding loops; other site 264730012106 ABC-ATPase subunit interface; other site 264730012107 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264730012108 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264730012109 Walker A/P-loop; other site 264730012110 ATP binding site [chemical binding]; other site 264730012111 Q-loop/lid; other site 264730012112 ABC transporter signature motif; other site 264730012113 Walker B; other site 264730012114 D-loop; other site 264730012115 H-loop/switch region; other site 264730012116 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 264730012117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730012118 dimer interface [polypeptide binding]; other site 264730012119 phosphorylation site [posttranslational modification] 264730012120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730012121 ATP binding site [chemical binding]; other site 264730012122 Mg2+ binding site [ion binding]; other site 264730012123 G-X-G motif; other site 264730012124 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264730012125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730012126 active site 264730012127 phosphorylation site [posttranslational modification] 264730012128 intermolecular recognition site; other site 264730012129 dimerization interface [polypeptide binding]; other site 264730012130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730012131 Walker A motif; other site 264730012132 ATP binding site [chemical binding]; other site 264730012133 Walker B motif; other site 264730012134 arginine finger; other site 264730012135 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730012136 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 264730012137 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 264730012138 catalytic residues [active] 264730012139 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 264730012140 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 264730012141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730012142 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 264730012143 putative dimerization interface [polypeptide binding]; other site 264730012144 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 264730012145 nudix motif; other site 264730012146 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 264730012147 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 264730012148 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 264730012149 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 264730012150 OpgC protein; Region: OpgC_C; pfam10129 264730012151 Exportin 1-like protein; Region: Xpo1; pfam08389 264730012152 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 264730012153 Transglycosylase; Region: Transgly; pfam00912 264730012154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264730012155 Predicted transcriptional regulators [Transcription]; Region: COG1695 264730012156 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 264730012157 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 264730012158 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 264730012159 FAD binding pocket [chemical binding]; other site 264730012160 FAD binding motif [chemical binding]; other site 264730012161 phosphate binding motif [ion binding]; other site 264730012162 NAD binding pocket [chemical binding]; other site 264730012163 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 264730012164 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 264730012165 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 264730012166 Trp docking motif [polypeptide binding]; other site 264730012167 putative active site [active] 264730012168 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 264730012169 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264730012170 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264730012171 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 264730012172 classical (c) SDRs; Region: SDR_c; cd05233 264730012173 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264730012174 NAD(P) binding site [chemical binding]; other site 264730012175 active site 264730012176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730012177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264730012178 NAD(P) binding site [chemical binding]; other site 264730012179 active site 264730012180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730012181 benzoate transport; Region: 2A0115; TIGR00895 264730012182 putative substrate translocation pore; other site 264730012183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730012184 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 264730012185 active site 264730012186 catalytic site [active] 264730012187 Zn binding site [ion binding]; other site 264730012188 tetramer interface [polypeptide binding]; other site 264730012189 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 264730012190 hypothetical protein; Provisional; Region: PRK06102 264730012191 Amidase; Region: Amidase; cl11426 264730012192 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264730012193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730012194 DNA-binding site [nucleotide binding]; DNA binding site 264730012195 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264730012196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730012197 DNA-binding site [nucleotide binding]; DNA binding site 264730012198 FCD domain; Region: FCD; pfam07729 264730012199 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 264730012200 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 264730012201 apolar tunnel; other site 264730012202 heme binding site [chemical binding]; other site 264730012203 dimerization interface [polypeptide binding]; other site 264730012204 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 264730012205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730012206 dimerization interface [polypeptide binding]; other site 264730012207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730012208 metal binding site [ion binding]; metal-binding site 264730012209 active site 264730012210 I-site; other site 264730012211 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730012212 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 264730012213 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 264730012214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730012215 Walker A motif; other site 264730012216 ATP binding site [chemical binding]; other site 264730012217 Walker B motif; other site 264730012218 arginine finger; other site 264730012219 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264730012220 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 264730012221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730012222 S-adenosylmethionine binding site [chemical binding]; other site 264730012223 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264730012224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730012225 S-adenosylmethionine binding site [chemical binding]; other site 264730012226 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 264730012227 active site 264730012228 hydrophilic channel; other site 264730012229 dimerization interface [polypeptide binding]; other site 264730012230 catalytic residues [active] 264730012231 active site lid [active] 264730012232 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 264730012233 Recombination protein O N terminal; Region: RecO_N; pfam11967 264730012234 Recombination protein O C terminal; Region: RecO_C; pfam02565 264730012235 GTPase Era; Reviewed; Region: era; PRK00089 264730012236 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 264730012237 G1 box; other site 264730012238 GTP/Mg2+ binding site [chemical binding]; other site 264730012239 Switch I region; other site 264730012240 G2 box; other site 264730012241 Switch II region; other site 264730012242 G3 box; other site 264730012243 G4 box; other site 264730012244 G5 box; other site 264730012245 ribonuclease III; Reviewed; Region: rnc; PRK00102 264730012246 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 264730012247 dimerization interface [polypeptide binding]; other site 264730012248 active site 264730012249 metal binding site [ion binding]; metal-binding site 264730012250 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 264730012251 dsRNA binding site [nucleotide binding]; other site 264730012252 signal peptidase I; Provisional; Region: PRK10861 264730012253 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264730012254 Catalytic site [active] 264730012255 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264730012256 GTP-binding protein LepA; Provisional; Region: PRK05433 264730012257 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 264730012258 G1 box; other site 264730012259 putative GEF interaction site [polypeptide binding]; other site 264730012260 GTP/Mg2+ binding site [chemical binding]; other site 264730012261 Switch I region; other site 264730012262 G2 box; other site 264730012263 G3 box; other site 264730012264 Switch II region; other site 264730012265 G4 box; other site 264730012266 G5 box; other site 264730012267 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 264730012268 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 264730012269 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 264730012270 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 264730012271 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264730012272 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264730012273 protein binding site [polypeptide binding]; other site 264730012274 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264730012275 protein binding site [polypeptide binding]; other site 264730012276 MucB/RseB family; Region: MucB_RseB; pfam03888 264730012277 anti-sigma E factor; Provisional; Region: rseB; PRK09455 264730012278 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 264730012279 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 264730012280 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 264730012281 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 264730012282 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730012283 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730012284 DNA binding residues [nucleotide binding] 264730012285 L-aspartate oxidase; Provisional; Region: PRK09077 264730012286 L-aspartate oxidase; Provisional; Region: PRK06175 264730012287 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264730012288 Uncharacterized conserved protein [Function unknown]; Region: COG2938 264730012289 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 264730012290 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 264730012291 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 264730012292 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 264730012293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730012294 HAMP domain; Region: HAMP; pfam00672 264730012295 dimerization interface [polypeptide binding]; other site 264730012296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730012297 dimer interface [polypeptide binding]; other site 264730012298 phosphorylation site [posttranslational modification] 264730012299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730012300 ATP binding site [chemical binding]; other site 264730012301 Mg2+ binding site [ion binding]; other site 264730012302 G-X-G motif; other site 264730012303 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 264730012304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730012305 active site 264730012306 phosphorylation site [posttranslational modification] 264730012307 intermolecular recognition site; other site 264730012308 dimerization interface [polypeptide binding]; other site 264730012309 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730012310 DNA binding site [nucleotide binding] 264730012311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264730012312 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 264730012313 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 264730012314 Putative ammonia monooxygenase; Region: AmoA; pfam05145 264730012315 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 264730012316 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 264730012317 ligand binding site [chemical binding]; other site 264730012318 active site 264730012319 UGI interface [polypeptide binding]; other site 264730012320 catalytic site [active] 264730012321 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 264730012322 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264730012323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264730012324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730012325 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264730012326 Walker A/P-loop; other site 264730012327 ATP binding site [chemical binding]; other site 264730012328 Q-loop/lid; other site 264730012329 ABC transporter signature motif; other site 264730012330 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 264730012331 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 264730012332 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 264730012333 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 264730012334 urea carboxylase; Region: urea_carbox; TIGR02712 264730012335 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264730012336 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264730012337 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 264730012338 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 264730012339 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 264730012340 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264730012341 carboxyltransferase (CT) interaction site; other site 264730012342 biotinylation site [posttranslational modification]; other site 264730012343 allophanate hydrolase; Provisional; Region: PRK08186 264730012344 Amidase; Region: Amidase; cl11426 264730012345 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730012346 MULE transposase domain; Region: MULE; pfam10551 264730012347 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 264730012348 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 264730012349 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264730012350 RNA binding surface [nucleotide binding]; other site 264730012351 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 264730012352 active site 264730012353 uracil binding [chemical binding]; other site 264730012354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730012355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730012356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730012357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264730012358 classical (c) SDRs; Region: SDR_c; cd05233 264730012359 NAD(P) binding site [chemical binding]; other site 264730012360 active site 264730012361 Biofilm formation and stress response factor; Region: BsmA; pfam10014 264730012362 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264730012363 EamA-like transporter family; Region: EamA; pfam00892 264730012364 EamA-like transporter family; Region: EamA; pfam00892 264730012365 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 264730012366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730012367 substrate binding pocket [chemical binding]; other site 264730012368 membrane-bound complex binding site; other site 264730012369 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730012370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730012371 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264730012372 putative effector binding pocket; other site 264730012373 dimerization interface [polypeptide binding]; other site 264730012374 Amb_all domain; Region: Amb_all; smart00656 264730012375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264730012376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264730012377 Coenzyme A binding pocket [chemical binding]; other site 264730012378 putative alcohol dehydrogenase; Provisional; Region: PRK09860 264730012379 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 264730012380 dimer interface [polypeptide binding]; other site 264730012381 active site 264730012382 metal binding site [ion binding]; metal-binding site 264730012383 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264730012384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730012385 S-adenosylmethionine binding site [chemical binding]; other site 264730012386 Repair protein; Region: Repair_PSII; cl01535 264730012387 Repair protein; Region: Repair_PSII; pfam04536 264730012388 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 264730012389 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264730012390 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 264730012391 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 264730012392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730012393 dimer interface [polypeptide binding]; other site 264730012394 phosphorylation site [posttranslational modification] 264730012395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730012396 ATP binding site [chemical binding]; other site 264730012397 Mg2+ binding site [ion binding]; other site 264730012398 G-X-G motif; other site 264730012399 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264730012400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730012401 active site 264730012402 phosphorylation site [posttranslational modification] 264730012403 intermolecular recognition site; other site 264730012404 dimerization interface [polypeptide binding]; other site 264730012405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730012406 Walker A motif; other site 264730012407 ATP binding site [chemical binding]; other site 264730012408 Walker B motif; other site 264730012409 arginine finger; other site 264730012410 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 264730012411 PAS fold; Region: PAS_4; pfam08448 264730012412 PAS fold; Region: PAS_4; pfam08448 264730012413 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 264730012414 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264730012415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730012416 putative active site [active] 264730012417 heme pocket [chemical binding]; other site 264730012418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730012419 dimer interface [polypeptide binding]; other site 264730012420 phosphorylation site [posttranslational modification] 264730012421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730012422 ATP binding site [chemical binding]; other site 264730012423 Mg2+ binding site [ion binding]; other site 264730012424 G-X-G motif; other site 264730012425 Response regulator receiver domain; Region: Response_reg; pfam00072 264730012426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730012427 active site 264730012428 phosphorylation site [posttranslational modification] 264730012429 intermolecular recognition site; other site 264730012430 dimerization interface [polypeptide binding]; other site 264730012431 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 264730012432 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 264730012433 nucleotide binding site [chemical binding]; other site 264730012434 putative NEF/HSP70 interaction site [polypeptide binding]; other site 264730012435 SBD interface [polypeptide binding]; other site 264730012436 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264730012437 HSP70 interaction site [polypeptide binding]; other site 264730012438 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 264730012439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730012440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730012441 putative substrate translocation pore; other site 264730012442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730012443 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 264730012444 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 264730012445 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730012446 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 264730012447 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 264730012448 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264730012449 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730012450 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264730012451 Protein export membrane protein; Region: SecD_SecF; cl14618 264730012452 Protein export membrane protein; Region: SecD_SecF; cl14618 264730012453 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264730012454 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 264730012455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730012456 putative substrate translocation pore; other site 264730012457 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 264730012458 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264730012459 dimer interface [polypeptide binding]; other site 264730012460 active site 264730012461 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 264730012462 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 264730012463 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 264730012464 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264730012465 Bacterial transcriptional regulator; Region: IclR; pfam01614 264730012466 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 264730012467 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 264730012468 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 264730012469 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 264730012470 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 264730012471 putative active site [active] 264730012472 putative substrate binding site [chemical binding]; other site 264730012473 putative cosubstrate binding site; other site 264730012474 catalytic site [active] 264730012475 exonuclease I; Provisional; Region: sbcB; PRK11779 264730012476 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 264730012477 active site 264730012478 catalytic site [active] 264730012479 substrate binding site [chemical binding]; other site 264730012480 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 264730012481 Predicted membrane protein/domain [Function unknown]; Region: COG1714 264730012482 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 264730012483 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 264730012484 GntP family permease; Region: GntP_permease; pfam02447 264730012485 fructuronate transporter; Provisional; Region: PRK10034; cl15264 264730012486 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 264730012487 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 264730012488 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264730012489 metal ion-dependent adhesion site (MIDAS); other site 264730012490 PilZ domain; Region: PilZ; pfam07238 264730012491 pyruvate kinase; Provisional; Region: PRK05826 264730012492 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 264730012493 domain interfaces; other site 264730012494 active site 264730012495 hypothetical protein; Provisional; Region: PRK05713 264730012496 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264730012497 catalytic loop [active] 264730012498 iron binding site [ion binding]; other site 264730012499 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 264730012500 FAD binding pocket [chemical binding]; other site 264730012501 conserved FAD binding motif [chemical binding]; other site 264730012502 phosphate binding motif [ion binding]; other site 264730012503 beta-alpha-beta structure motif; other site 264730012504 NAD binding pocket [chemical binding]; other site 264730012505 putative fumarate hydratase; Provisional; Region: PRK15392 264730012506 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 264730012507 Fumarase C-terminus; Region: Fumerase_C; pfam05683 264730012508 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264730012509 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264730012510 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730012511 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730012512 MULE transposase domain; Region: MULE; pfam10551 264730012513 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 264730012514 PLD-like domain; Region: PLDc_2; pfam13091 264730012515 putative active site [active] 264730012516 catalytic site [active] 264730012517 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 264730012518 PLD-like domain; Region: PLDc_2; pfam13091 264730012519 putative active site [active] 264730012520 catalytic site [active] 264730012521 YceI-like domain; Region: YceI; pfam04264 264730012522 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264730012523 Beta-lactamase; Region: Beta-lactamase; pfam00144 264730012524 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 264730012525 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264730012526 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264730012527 putative acyl-acceptor binding pocket; other site 264730012528 Protein of unknown function, DUF479; Region: DUF479; cl01203 264730012529 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730012530 dimerization interface [polypeptide binding]; other site 264730012531 putative DNA binding site [nucleotide binding]; other site 264730012532 putative Zn2+ binding site [ion binding]; other site 264730012533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730012534 putative substrate translocation pore; other site 264730012535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730012536 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 264730012537 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 264730012538 FMN binding site [chemical binding]; other site 264730012539 active site 264730012540 substrate binding site [chemical binding]; other site 264730012541 catalytic residue [active] 264730012542 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264730012543 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264730012544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730012545 NAD(P) binding site [chemical binding]; other site 264730012546 active site 264730012547 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 264730012548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730012549 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730012550 dimerization interface [polypeptide binding]; other site 264730012551 Lysine efflux permease [General function prediction only]; Region: COG1279 264730012552 superoxide dismutase; Provisional; Region: PRK10543 264730012553 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 264730012554 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 264730012555 biofilm formation regulator HmsP; Provisional; Region: PRK11829 264730012556 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730012557 metal binding site [ion binding]; metal-binding site 264730012558 active site 264730012559 I-site; other site 264730012560 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730012561 Imelysin; Region: Peptidase_M75; cl09159 264730012562 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 264730012563 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 264730012564 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 264730012565 Imelysin; Region: Peptidase_M75; cl09159 264730012566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 264730012567 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 264730012568 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264730012569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730012570 S-adenosylmethionine binding site [chemical binding]; other site 264730012571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730012572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730012573 dimer interface [polypeptide binding]; other site 264730012574 phosphorylation site [posttranslational modification] 264730012575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730012576 ATP binding site [chemical binding]; other site 264730012577 Mg2+ binding site [ion binding]; other site 264730012578 G-X-G motif; other site 264730012579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264730012580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730012581 active site 264730012582 phosphorylation site [posttranslational modification] 264730012583 intermolecular recognition site; other site 264730012584 dimerization interface [polypeptide binding]; other site 264730012585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730012586 DNA binding site [nucleotide binding] 264730012587 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 264730012588 active site 264730012589 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 264730012590 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264730012591 ring oligomerisation interface [polypeptide binding]; other site 264730012592 ATP/Mg binding site [chemical binding]; other site 264730012593 stacking interactions; other site 264730012594 hinge regions; other site 264730012595 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264730012596 oligomerisation interface [polypeptide binding]; other site 264730012597 mobile loop; other site 264730012598 roof hairpin; other site 264730012599 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 264730012600 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 264730012601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730012602 NAD(P) binding site [chemical binding]; other site 264730012603 active site 264730012604 Protein of unknown function, DUF481; Region: DUF481; pfam04338 264730012605 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264730012606 DNA binding site [nucleotide binding] 264730012607 active site 264730012608 muropeptide transporter; Validated; Region: ampG; cl17669 264730012609 muropeptide transporter; Validated; Region: ampG; cl17669 264730012610 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730012611 MULE transposase domain; Region: MULE; pfam10551 264730012612 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 264730012613 PAAR motif; Region: PAAR_motif; pfam05488 264730012614 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264730012615 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264730012616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 264730012617 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 264730012618 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730012619 dimerization interface [polypeptide binding]; other site 264730012620 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264730012621 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730012622 putative active site [active] 264730012623 heme pocket [chemical binding]; other site 264730012624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730012625 dimer interface [polypeptide binding]; other site 264730012626 phosphorylation site [posttranslational modification] 264730012627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730012628 ATP binding site [chemical binding]; other site 264730012629 Mg2+ binding site [ion binding]; other site 264730012630 G-X-G motif; other site 264730012631 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 264730012632 hypothetical protein; Provisional; Region: PRK08999 264730012633 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 264730012634 active site 264730012635 8-oxo-dGMP binding site [chemical binding]; other site 264730012636 nudix motif; other site 264730012637 metal binding site [ion binding]; metal-binding site 264730012638 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 264730012639 thiamine phosphate binding site [chemical binding]; other site 264730012640 active site 264730012641 pyrophosphate binding site [ion binding]; other site 264730012642 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 264730012643 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264730012644 putative C-terminal domain interface [polypeptide binding]; other site 264730012645 putative GSH binding site (G-site) [chemical binding]; other site 264730012646 putative dimer interface [polypeptide binding]; other site 264730012647 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 264730012648 putative substrate binding pocket (H-site) [chemical binding]; other site 264730012649 putative N-terminal domain interface [polypeptide binding]; other site 264730012650 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 264730012651 heterotetramer interface [polypeptide binding]; other site 264730012652 active site pocket [active] 264730012653 cleavage site 264730012654 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 264730012655 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 264730012656 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 264730012657 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 264730012658 nucleotide binding region [chemical binding]; other site 264730012659 ATP-binding site [chemical binding]; other site 264730012660 SEC-C motif; Region: SEC-C; pfam02810 264730012661 Protein of unknown function (DUF721); Region: DUF721; pfam05258 264730012662 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 264730012663 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 264730012664 cell division protein FtsZ; Validated; Region: PRK09330 264730012665 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 264730012666 nucleotide binding site [chemical binding]; other site 264730012667 SulA interaction site; other site 264730012668 cell division protein FtsA; Region: ftsA; TIGR01174 264730012669 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264730012670 nucleotide binding site [chemical binding]; other site 264730012671 Cell division protein FtsA; Region: FtsA; pfam14450 264730012672 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 264730012673 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 264730012674 Cell division protein FtsQ; Region: FtsQ; pfam03799 264730012675 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 264730012676 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 264730012677 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264730012678 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 264730012679 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264730012680 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264730012681 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264730012682 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 264730012683 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 264730012684 active site 264730012685 homodimer interface [polypeptide binding]; other site 264730012686 cell division protein FtsW; Region: ftsW; TIGR02614 264730012687 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 264730012688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264730012689 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264730012690 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 264730012691 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 264730012692 Mg++ binding site [ion binding]; other site 264730012693 putative catalytic motif [active] 264730012694 putative substrate binding site [chemical binding]; other site 264730012695 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264730012696 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 264730012697 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264730012698 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264730012699 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 264730012700 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264730012701 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264730012702 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264730012703 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 264730012704 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264730012705 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264730012706 Cell division protein FtsL; Region: FtsL; pfam04999 264730012707 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 264730012708 MraW methylase family; Region: Methyltransf_5; cl17771 264730012709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 264730012710 MraZ protein; Region: MraZ; pfam02381 264730012711 MraZ protein; Region: MraZ; pfam02381 264730012712 Predicted methyltransferases [General function prediction only]; Region: COG0313 264730012713 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 264730012714 putative SAM binding site [chemical binding]; other site 264730012715 putative homodimer interface [polypeptide binding]; other site 264730012716 LppC putative lipoprotein; Region: LppC; pfam04348 264730012717 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 264730012718 putative ligand binding site [chemical binding]; other site 264730012719 hypothetical protein; Reviewed; Region: PRK12497 264730012720 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 264730012721 dimer interface [polypeptide binding]; other site 264730012722 active site 264730012723 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264730012724 BON domain; Region: BON; pfam04972 264730012725 BON domain; Region: BON; pfam04972 264730012726 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 264730012727 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 264730012728 stringent starvation protein A; Provisional; Region: sspA; PRK09481 264730012729 C-terminal domain interface [polypeptide binding]; other site 264730012730 putative GSH binding site (G-site) [chemical binding]; other site 264730012731 dimer interface [polypeptide binding]; other site 264730012732 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 264730012733 dimer interface [polypeptide binding]; other site 264730012734 N-terminal domain interface [polypeptide binding]; other site 264730012735 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 264730012736 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 264730012737 23S rRNA interface [nucleotide binding]; other site 264730012738 L3 interface [polypeptide binding]; other site 264730012739 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264730012740 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 264730012741 conserved cys residue [active] 264730012742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730012743 Predicted ATPase [General function prediction only]; Region: COG1485 264730012744 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 264730012745 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 264730012746 active site 264730012747 HIGH motif; other site 264730012748 dimer interface [polypeptide binding]; other site 264730012749 KMSKS motif; other site 264730012750 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264730012751 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 264730012752 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 264730012753 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 264730012754 CysD dimerization site [polypeptide binding]; other site 264730012755 G1 box; other site 264730012756 putative GEF interaction site [polypeptide binding]; other site 264730012757 GTP/Mg2+ binding site [chemical binding]; other site 264730012758 Switch I region; other site 264730012759 G2 box; other site 264730012760 G3 box; other site 264730012761 Switch II region; other site 264730012762 G4 box; other site 264730012763 G5 box; other site 264730012764 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 264730012765 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 264730012766 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 264730012767 ligand-binding site [chemical binding]; other site 264730012768 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 264730012769 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 264730012770 Active Sites [active] 264730012771 Uncharacterized conserved protein [Function unknown]; Region: COG0327 264730012772 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 264730012773 serine endoprotease; Provisional; Region: PRK10898 264730012774 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264730012775 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264730012776 protein binding site [polypeptide binding]; other site 264730012777 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 264730012778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730012779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730012780 homodimer interface [polypeptide binding]; other site 264730012781 catalytic residue [active] 264730012782 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 264730012783 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 264730012784 NAD binding site [chemical binding]; other site 264730012785 dimerization interface [polypeptide binding]; other site 264730012786 product binding site; other site 264730012787 substrate binding site [chemical binding]; other site 264730012788 zinc binding site [ion binding]; other site 264730012789 catalytic residues [active] 264730012790 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 264730012791 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 264730012792 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 264730012793 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 264730012794 hinge; other site 264730012795 active site 264730012796 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 264730012797 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264730012798 anti sigma factor interaction site; other site 264730012799 regulatory phosphorylation site [posttranslational modification]; other site 264730012800 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 264730012801 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 264730012802 mce related protein; Region: MCE; pfam02470 264730012803 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 264730012804 Permease; Region: Permease; cl00510 264730012805 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 264730012806 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 264730012807 Walker A/P-loop; other site 264730012808 ATP binding site [chemical binding]; other site 264730012809 Q-loop/lid; other site 264730012810 ABC transporter signature motif; other site 264730012811 Walker B; other site 264730012812 D-loop; other site 264730012813 H-loop/switch region; other site 264730012814 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 264730012815 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 264730012816 putative active site [active] 264730012817 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 264730012818 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 264730012819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730012820 active site 264730012821 motif I; other site 264730012822 motif II; other site 264730012823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 264730012824 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 264730012825 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 264730012826 OstA-like protein; Region: OstA; pfam03968 264730012827 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 264730012828 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 264730012829 Walker A/P-loop; other site 264730012830 ATP binding site [chemical binding]; other site 264730012831 Q-loop/lid; other site 264730012832 ABC transporter signature motif; other site 264730012833 Walker B; other site 264730012834 D-loop; other site 264730012835 H-loop/switch region; other site 264730012836 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 264730012837 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 264730012838 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 264730012839 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 264730012840 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 264730012841 30S subunit binding site; other site 264730012842 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 264730012843 active site 264730012844 phosphorylation site [posttranslational modification] 264730012845 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 264730012846 AAA domain; Region: AAA_18; pfam13238 264730012847 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 264730012848 dimerization domain swap beta strand [polypeptide binding]; other site 264730012849 regulatory protein interface [polypeptide binding]; other site 264730012850 active site 264730012851 regulatory phosphorylation site [posttranslational modification]; other site 264730012852 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 264730012853 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 264730012854 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 264730012855 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730012856 MULE transposase domain; Region: MULE; pfam10551 264730012857 Lipoprotein amino terminal region; Region: Vitellogenin_N; pfam01347 264730012858 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730012859 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730012860 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730012861 fumarate hydratase; Reviewed; Region: fumC; PRK00485 264730012862 Class II fumarases; Region: Fumarase_classII; cd01362 264730012863 active site 264730012864 tetramer interface [polypeptide binding]; other site 264730012865 peptidase PmbA; Provisional; Region: PRK11040 264730012866 hypothetical protein; Provisional; Region: PRK05255 264730012867 protease TldD; Provisional; Region: tldD; PRK10735 264730012868 nitrilase; Region: PLN02798 264730012869 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 264730012870 putative active site [active] 264730012871 catalytic triad [active] 264730012872 dimer interface [polypeptide binding]; other site 264730012873 TIGR02099 family protein; Region: TIGR02099 264730012874 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 264730012875 ribonuclease G; Provisional; Region: PRK11712 264730012876 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 264730012877 homodimer interface [polypeptide binding]; other site 264730012878 oligonucleotide binding site [chemical binding]; other site 264730012879 Maf-like protein; Region: Maf; pfam02545 264730012880 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264730012881 active site 264730012882 dimer interface [polypeptide binding]; other site 264730012883 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 264730012884 rod shape-determining protein MreC; Provisional; Region: PRK13922 264730012885 rod shape-determining protein MreC; Region: MreC; pfam04085 264730012886 rod shape-determining protein MreB; Provisional; Region: PRK13927 264730012887 MreB and similar proteins; Region: MreB_like; cd10225 264730012888 nucleotide binding site [chemical binding]; other site 264730012889 Mg binding site [ion binding]; other site 264730012890 putative protofilament interaction site [polypeptide binding]; other site 264730012891 RodZ interaction site [polypeptide binding]; other site 264730012892 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 264730012893 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264730012894 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 264730012895 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 264730012896 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 264730012897 GatB domain; Region: GatB_Yqey; smart00845 264730012898 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 264730012899 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 264730012900 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 264730012901 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 264730012902 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 264730012903 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 264730012904 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264730012905 Predicted permeases [General function prediction only]; Region: COG0679 264730012906 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 264730012907 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264730012908 putative active site [active] 264730012909 putative metal binding site [ion binding]; other site 264730012910 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264730012911 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 264730012912 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 264730012913 putative RNA binding site [nucleotide binding]; other site 264730012914 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264730012915 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264730012916 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264730012917 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 264730012918 ligand binding site [chemical binding]; other site 264730012919 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 264730012920 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264730012921 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 264730012922 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 264730012923 RNase E interface [polypeptide binding]; other site 264730012924 trimer interface [polypeptide binding]; other site 264730012925 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 264730012926 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 264730012927 RNase E interface [polypeptide binding]; other site 264730012928 trimer interface [polypeptide binding]; other site 264730012929 active site 264730012930 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 264730012931 putative nucleic acid binding region [nucleotide binding]; other site 264730012932 G-X-X-G motif; other site 264730012933 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 264730012934 RNA binding site [nucleotide binding]; other site 264730012935 domain interface; other site 264730012936 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 264730012937 16S/18S rRNA binding site [nucleotide binding]; other site 264730012938 S13e-L30e interaction site [polypeptide binding]; other site 264730012939 25S rRNA binding site [nucleotide binding]; other site 264730012940 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 264730012941 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 264730012942 RNA binding site [nucleotide binding]; other site 264730012943 active site 264730012944 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 264730012945 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 264730012946 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 264730012947 translation initiation factor IF-2; Region: IF-2; TIGR00487 264730012948 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 264730012949 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 264730012950 G1 box; other site 264730012951 putative GEF interaction site [polypeptide binding]; other site 264730012952 GTP/Mg2+ binding site [chemical binding]; other site 264730012953 Switch I region; other site 264730012954 G2 box; other site 264730012955 G3 box; other site 264730012956 Switch II region; other site 264730012957 G4 box; other site 264730012958 G5 box; other site 264730012959 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 264730012960 Translation-initiation factor 2; Region: IF-2; pfam11987 264730012961 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 264730012962 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 264730012963 NusA N-terminal domain; Region: NusA_N; pfam08529 264730012964 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 264730012965 RNA binding site [nucleotide binding]; other site 264730012966 homodimer interface [polypeptide binding]; other site 264730012967 NusA-like KH domain; Region: KH_5; pfam13184 264730012968 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 264730012969 G-X-X-G motif; other site 264730012970 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 264730012971 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 264730012972 ribosome maturation protein RimP; Reviewed; Region: PRK00092 264730012973 Sm and related proteins; Region: Sm_like; cl00259 264730012974 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 264730012975 putative oligomer interface [polypeptide binding]; other site 264730012976 putative RNA binding site [nucleotide binding]; other site 264730012977 Preprotein translocase SecG subunit; Region: SecG; pfam03840 264730012978 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 264730012979 triosephosphate isomerase; Provisional; Region: PRK14567 264730012980 substrate binding site [chemical binding]; other site 264730012981 dimer interface [polypeptide binding]; other site 264730012982 catalytic triad [active] 264730012983 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 264730012984 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 264730012985 active site 264730012986 substrate binding site [chemical binding]; other site 264730012987 metal binding site [ion binding]; metal-binding site 264730012988 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 264730012989 dihydropteroate synthase; Region: DHPS; TIGR01496 264730012990 substrate binding pocket [chemical binding]; other site 264730012991 dimer interface [polypeptide binding]; other site 264730012992 inhibitor binding site; inhibition site 264730012993 FtsH Extracellular; Region: FtsH_ext; pfam06480 264730012994 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264730012995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730012996 Walker A motif; other site 264730012997 ATP binding site [chemical binding]; other site 264730012998 Walker B motif; other site 264730012999 arginine finger; other site 264730013000 Peptidase family M41; Region: Peptidase_M41; pfam01434 264730013001 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 264730013002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730013003 S-adenosylmethionine binding site [chemical binding]; other site 264730013004 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 264730013005 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 264730013006 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264730013007 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264730013008 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 264730013009 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264730013010 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 264730013011 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 264730013012 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264730013013 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264730013014 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 264730013015 IMP binding site; other site 264730013016 dimer interface [polypeptide binding]; other site 264730013017 interdomain contacts; other site 264730013018 partial ornithine binding site; other site 264730013019 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 264730013020 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 264730013021 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 264730013022 catalytic site [active] 264730013023 subunit interface [polypeptide binding]; other site 264730013024 dihydrodipicolinate reductase; Provisional; Region: PRK00048 264730013025 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 264730013026 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 264730013027 chaperone protein DnaJ; Provisional; Region: PRK10767 264730013028 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264730013029 HSP70 interaction site [polypeptide binding]; other site 264730013030 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 264730013031 substrate binding site [polypeptide binding]; other site 264730013032 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 264730013033 Zn binding sites [ion binding]; other site 264730013034 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264730013035 dimer interface [polypeptide binding]; other site 264730013036 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 264730013037 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 264730013038 nucleotide binding site [chemical binding]; other site 264730013039 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 264730013040 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 264730013041 dimer interface [polypeptide binding]; other site 264730013042 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 264730013043 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 264730013044 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264730013045 Walker A/P-loop; other site 264730013046 ATP binding site [chemical binding]; other site 264730013047 Q-loop/lid; other site 264730013048 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264730013049 ABC transporter signature motif; other site 264730013050 Walker B; other site 264730013051 D-loop; other site 264730013052 H-loop/switch region; other site 264730013053 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264730013054 metal binding site 2 [ion binding]; metal-binding site 264730013055 putative DNA binding helix; other site 264730013056 metal binding site 1 [ion binding]; metal-binding site 264730013057 dimer interface [polypeptide binding]; other site 264730013058 structural Zn2+ binding site [ion binding]; other site 264730013059 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 264730013060 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 264730013061 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 264730013062 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 264730013063 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 264730013064 putative coenzyme Q binding site [chemical binding]; other site 264730013065 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 264730013066 Na2 binding site [ion binding]; other site 264730013067 putative substrate binding site 1 [chemical binding]; other site 264730013068 Na binding site 1 [ion binding]; other site 264730013069 putative substrate binding site 2 [chemical binding]; other site 264730013070 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 264730013071 SmpB-tmRNA interface; other site 264730013072 K+-transporting ATPase, c chain; Region: KdpC; cl00944 264730013073 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730013074 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 264730013075 Int/Topo IB signature motif; other site 264730013076 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 264730013077 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 264730013078 putative active site [active] 264730013079 putative NTP binding site [chemical binding]; other site 264730013080 putative nucleic acid binding site [nucleotide binding]; other site 264730013081 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 264730013082 active site 264730013083 DNA binding site [nucleotide binding] 264730013084 catalytic site [active] 264730013085 multiple promoter invertase; Provisional; Region: mpi; PRK13413 264730013086 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 264730013087 catalytic residues [active] 264730013088 catalytic nucleophile [active] 264730013089 Presynaptic Site I dimer interface [polypeptide binding]; other site 264730013090 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 264730013091 Synaptic Flat tetramer interface [polypeptide binding]; other site 264730013092 Synaptic Site I dimer interface [polypeptide binding]; other site 264730013093 DNA binding site [nucleotide binding] 264730013094 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264730013095 Protein of unknown function (DUF796); Region: DUF796; pfam05638 264730013096 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 264730013097 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 264730013098 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730013099 MULE transposase domain; Region: MULE; pfam10551 264730013100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264730013101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730013102 Coenzyme A binding pocket [chemical binding]; other site 264730013103 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 264730013104 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 264730013105 dimer interface [polypeptide binding]; other site 264730013106 active site 264730013107 heme binding site [chemical binding]; other site 264730013108 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 264730013109 PAS fold; Region: PAS_3; pfam08447 264730013110 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 264730013111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730013112 PAS fold; Region: PAS_3; pfam08447 264730013113 putative active site [active] 264730013114 heme pocket [chemical binding]; other site 264730013115 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730013116 putative CheW interface [polypeptide binding]; other site 264730013117 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 264730013118 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264730013119 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730013120 Walker A/P-loop; other site 264730013121 ATP binding site [chemical binding]; other site 264730013122 Q-loop/lid; other site 264730013123 ABC transporter signature motif; other site 264730013124 Walker B; other site 264730013125 D-loop; other site 264730013126 H-loop/switch region; other site 264730013127 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730013128 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264730013129 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730013130 Walker A/P-loop; other site 264730013131 ATP binding site [chemical binding]; other site 264730013132 Q-loop/lid; other site 264730013133 ABC transporter signature motif; other site 264730013134 Walker B; other site 264730013135 D-loop; other site 264730013136 H-loop/switch region; other site 264730013137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 264730013138 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 264730013139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730013140 dimer interface [polypeptide binding]; other site 264730013141 conserved gate region; other site 264730013142 putative PBP binding loops; other site 264730013143 ABC-ATPase subunit interface; other site 264730013144 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264730013145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730013146 dimer interface [polypeptide binding]; other site 264730013147 conserved gate region; other site 264730013148 putative PBP binding loops; other site 264730013149 ABC-ATPase subunit interface; other site 264730013150 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 264730013151 Autoinducer binding domain; Region: Autoind_bind; pfam03472 264730013152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730013153 DNA binding residues [nucleotide binding] 264730013154 dimerization interface [polypeptide binding]; other site 264730013155 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 264730013156 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730013157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730013158 dimerization interface [polypeptide binding]; other site 264730013159 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730013160 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730013161 dimer interface [polypeptide binding]; other site 264730013162 putative CheW interface [polypeptide binding]; other site 264730013163 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730013164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730013165 active site 264730013166 phosphorylation site [posttranslational modification] 264730013167 intermolecular recognition site; other site 264730013168 dimerization interface [polypeptide binding]; other site 264730013169 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730013170 DNA binding residues [nucleotide binding] 264730013171 dimerization interface [polypeptide binding]; other site 264730013172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730013173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730013174 dimer interface [polypeptide binding]; other site 264730013175 phosphorylation site [posttranslational modification] 264730013176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730013177 ATP binding site [chemical binding]; other site 264730013178 Mg2+ binding site [ion binding]; other site 264730013179 G-X-G motif; other site 264730013180 Response regulator receiver domain; Region: Response_reg; pfam00072 264730013181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730013182 active site 264730013183 phosphorylation site [posttranslational modification] 264730013184 intermolecular recognition site; other site 264730013185 dimerization interface [polypeptide binding]; other site 264730013186 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 264730013187 GAF domain; Region: GAF; cl17456 264730013188 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264730013189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730013190 Coenzyme A binding pocket [chemical binding]; other site 264730013191 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 264730013192 GAF domain; Region: GAF; pfam01590 264730013193 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730013194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730013195 metal binding site [ion binding]; metal-binding site 264730013196 active site 264730013197 I-site; other site 264730013198 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730013199 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264730013200 galactarate dehydratase; Region: galactar-dH20; TIGR03248 264730013201 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264730013202 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264730013203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730013204 D-galactonate transporter; Region: 2A0114; TIGR00893 264730013205 putative substrate translocation pore; other site 264730013206 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 264730013207 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 264730013208 putative active site [active] 264730013209 catalytic residue [active] 264730013210 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730013211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730013212 DNA-binding site [nucleotide binding]; DNA binding site 264730013213 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264730013214 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 264730013215 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 264730013216 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 264730013217 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 264730013218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730013219 active site 264730013220 phosphorylation site [posttranslational modification] 264730013221 intermolecular recognition site; other site 264730013222 dimerization interface [polypeptide binding]; other site 264730013223 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730013224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730013225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 264730013226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730013227 ATP binding site [chemical binding]; other site 264730013228 G-X-G motif; other site 264730013229 Protein of unknown function (DUF541); Region: SIMPL; cl01077 264730013230 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264730013231 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 264730013232 peptide binding site [polypeptide binding]; other site 264730013233 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264730013234 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 264730013235 peptide binding site [polypeptide binding]; other site 264730013236 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264730013237 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 264730013238 peptide binding site [polypeptide binding]; other site 264730013239 outer membrane porin, OprD family; Region: OprD; pfam03573 264730013240 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 264730013241 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264730013242 peptide binding site [polypeptide binding]; other site 264730013243 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264730013244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730013245 dimer interface [polypeptide binding]; other site 264730013246 conserved gate region; other site 264730013247 putative PBP binding loops; other site 264730013248 ABC-ATPase subunit interface; other site 264730013249 dipeptide transporter; Provisional; Region: PRK10913 264730013250 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 264730013251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730013252 putative PBP binding loops; other site 264730013253 dimer interface [polypeptide binding]; other site 264730013254 ABC-ATPase subunit interface; other site 264730013255 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264730013256 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730013257 Walker A/P-loop; other site 264730013258 ATP binding site [chemical binding]; other site 264730013259 Q-loop/lid; other site 264730013260 ABC transporter signature motif; other site 264730013261 Walker B; other site 264730013262 D-loop; other site 264730013263 H-loop/switch region; other site 264730013264 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730013265 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 264730013266 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730013267 Walker A/P-loop; other site 264730013268 ATP binding site [chemical binding]; other site 264730013269 Q-loop/lid; other site 264730013270 ABC transporter signature motif; other site 264730013271 Walker B; other site 264730013272 D-loop; other site 264730013273 H-loop/switch region; other site 264730013274 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 264730013275 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730013276 MULE transposase domain; Region: MULE; pfam10551 264730013277 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 264730013278 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 264730013279 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 264730013280 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 264730013281 Flavodoxin; Region: Flavodoxin_1; pfam00258 264730013282 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 264730013283 FAD binding pocket [chemical binding]; other site 264730013284 FAD binding motif [chemical binding]; other site 264730013285 catalytic residues [active] 264730013286 NAD binding pocket [chemical binding]; other site 264730013287 phosphate binding motif [ion binding]; other site 264730013288 beta-alpha-beta structure motif; other site 264730013289 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730013290 MULE transposase domain; Region: MULE; pfam10551 264730013291 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 264730013292 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 264730013293 dimer interface [polypeptide binding]; other site 264730013294 active site 264730013295 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264730013296 catalytic residues [active] 264730013297 substrate binding site [chemical binding]; other site 264730013298 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730013299 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730013300 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730013301 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730013302 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 264730013303 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 264730013304 Walker A/P-loop; other site 264730013305 ATP binding site [chemical binding]; other site 264730013306 Q-loop/lid; other site 264730013307 ABC transporter signature motif; other site 264730013308 Walker B; other site 264730013309 D-loop; other site 264730013310 H-loop/switch region; other site 264730013311 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264730013312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730013313 dimer interface [polypeptide binding]; other site 264730013314 conserved gate region; other site 264730013315 ABC-ATPase subunit interface; other site 264730013316 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264730013317 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 264730013318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730013319 ABC-ATPase subunit interface; other site 264730013320 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 264730013321 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 264730013322 G1 box; other site 264730013323 putative GEF interaction site [polypeptide binding]; other site 264730013324 GTP/Mg2+ binding site [chemical binding]; other site 264730013325 Switch I region; other site 264730013326 G2 box; other site 264730013327 G3 box; other site 264730013328 Switch II region; other site 264730013329 G4 box; other site 264730013330 G5 box; other site 264730013331 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 264730013332 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 264730013333 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 264730013334 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264730013335 hypothetical protein; Provisional; Region: PRK05208 264730013336 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730013337 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730013338 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730013339 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 264730013340 AAA domain; Region: AAA_32; pfam13654 264730013341 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264730013342 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 264730013343 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 264730013344 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 264730013345 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 264730013346 transcription elongation factor regulatory protein; Validated; Region: PRK06342 264730013347 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264730013348 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 264730013349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730013350 Walker A/P-loop; other site 264730013351 ATP binding site [chemical binding]; other site 264730013352 Q-loop/lid; other site 264730013353 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264730013354 ABC transporter signature motif; other site 264730013355 Walker B; other site 264730013356 D-loop; other site 264730013357 ABC transporter; Region: ABC_tran_2; pfam12848 264730013358 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264730013359 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264730013360 active site 264730013361 catalytic residues [active] 264730013362 Int/Topo IB signature motif; other site 264730013363 DNA binding site [nucleotide binding] 264730013364 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264730013365 DNA binding site [nucleotide binding] 264730013366 Int/Topo IB signature motif; other site 264730013367 active site 264730013368 catalytic residues [active] 264730013369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 264730013370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 264730013371 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 264730013372 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 264730013373 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 264730013374 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 264730013375 MFS/sugar transport protein; Region: MFS_2; pfam13347 264730013376 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 264730013377 ligand-binding site [chemical binding]; other site 264730013378 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 264730013379 Amidinotransferase; Region: Amidinotransf; cl12043 264730013380 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 264730013381 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 264730013382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730013383 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 264730013384 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 264730013385 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 264730013386 active site 264730013387 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264730013388 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 264730013389 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264730013390 trimer interface [polypeptide binding]; other site 264730013391 active site 264730013392 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 264730013393 trimer interface [polypeptide binding]; other site 264730013394 active site 264730013395 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 264730013396 Fatty acid desaturase; Region: FA_desaturase; pfam00487 264730013397 putative di-iron ligands [ion binding]; other site 264730013398 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 264730013399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730013400 NAD(P) binding site [chemical binding]; other site 264730013401 active site 264730013402 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 264730013403 putative hydrophobic ligand binding site [chemical binding]; other site 264730013404 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 264730013405 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264730013406 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730013407 catalytic residue [active] 264730013408 ornithine carbamoyltransferase; Validated; Region: PRK02102 264730013409 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264730013410 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264730013411 Helix-turn-helix domain; Region: HTH_28; pfam13518 264730013412 Winged helix-turn helix; Region: HTH_29; pfam13551 264730013413 Homeodomain-like domain; Region: HTH_32; pfam13565 264730013414 DDE superfamily endonuclease; Region: DDE_3; pfam13358 264730013415 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 264730013416 NAD-dependent deacetylase; Provisional; Region: PRK00481 264730013417 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 264730013418 NAD+ binding site [chemical binding]; other site 264730013419 substrate binding site [chemical binding]; other site 264730013420 Zn binding site [ion binding]; other site 264730013421 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264730013422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730013423 non-specific DNA binding site [nucleotide binding]; other site 264730013424 salt bridge; other site 264730013425 sequence-specific DNA binding site [nucleotide binding]; other site 264730013426 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 264730013427 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264730013428 dimer interface [polypeptide binding]; other site 264730013429 active site 264730013430 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264730013431 folate binding site [chemical binding]; other site 264730013432 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 264730013433 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 264730013434 P-loop, Walker A motif; other site 264730013435 Base recognition motif; other site 264730013436 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 264730013437 Uncharacterized small protein [Function unknown]; Region: COG2879 264730013438 carbon starvation protein A; Provisional; Region: PRK15015 264730013439 Carbon starvation protein CstA; Region: CstA; pfam02554 264730013440 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 264730013441 PilZ domain; Region: PilZ; pfam07238 264730013442 DNA repair protein RadA; Provisional; Region: PRK11823 264730013443 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 264730013444 Walker A motif/ATP binding site; other site 264730013445 ATP binding site [chemical binding]; other site 264730013446 Walker B motif; other site 264730013447 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264730013448 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 264730013449 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 264730013450 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264730013451 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 264730013452 FAD binding pocket [chemical binding]; other site 264730013453 FAD binding motif [chemical binding]; other site 264730013454 phosphate binding motif [ion binding]; other site 264730013455 beta-alpha-beta structure motif; other site 264730013456 NAD binding pocket [chemical binding]; other site 264730013457 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730013458 MULE transposase domain; Region: MULE; pfam10551 264730013459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 264730013460 DNA binding residues [nucleotide binding] 264730013461 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 264730013462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730013463 S-adenosylmethionine binding site [chemical binding]; other site 264730013464 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 264730013465 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 264730013466 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 264730013467 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 264730013468 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 264730013469 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264730013470 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 264730013471 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264730013472 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264730013473 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 264730013474 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 264730013475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730013476 S-adenosylmethionine binding site [chemical binding]; other site 264730013477 enterobactin exporter EntS; Provisional; Region: PRK10489 264730013478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730013479 putative substrate translocation pore; other site 264730013480 Predicted metalloprotease [General function prediction only]; Region: COG2321 264730013481 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 264730013482 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264730013483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730013484 active site 264730013485 motif I; other site 264730013486 motif II; other site 264730013487 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 264730013488 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 264730013489 active site 264730013490 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 264730013491 catalytic triad [active] 264730013492 dimer interface [polypeptide binding]; other site 264730013493 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264730013494 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264730013495 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 264730013496 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 264730013497 putative active site [active] 264730013498 Zn binding site [ion binding]; other site 264730013499 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 264730013500 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264730013501 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264730013502 ATP binding site [chemical binding]; other site 264730013503 Mg++ binding site [ion binding]; other site 264730013504 motif III; other site 264730013505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264730013506 nucleotide binding region [chemical binding]; other site 264730013507 ATP-binding site [chemical binding]; other site 264730013508 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 264730013509 EamA-like transporter family; Region: EamA; pfam00892 264730013510 EamA-like transporter family; Region: EamA; pfam00892 264730013511 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264730013512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730013513 putative DNA binding site [nucleotide binding]; other site 264730013514 putative Zn2+ binding site [ion binding]; other site 264730013515 AsnC family; Region: AsnC_trans_reg; pfam01037 264730013516 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264730013517 active site 264730013518 catalytic site [active] 264730013519 substrate binding site [chemical binding]; other site 264730013520 Uncharacterized conserved protein [Function unknown]; Region: COG1432 264730013521 LabA_like proteins; Region: LabA; cd10911 264730013522 putative metal binding site [ion binding]; other site 264730013523 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 264730013524 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 264730013525 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 264730013526 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264730013527 putative catalytic site [active] 264730013528 putative metal binding site [ion binding]; other site 264730013529 putative phosphate binding site [ion binding]; other site 264730013530 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730013531 MULE transposase domain; Region: MULE; pfam10551 264730013532 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 264730013533 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730013534 MULE transposase domain; Region: MULE; pfam10551 264730013535 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 264730013536 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264730013537 HSP70 interaction site [polypeptide binding]; other site 264730013538 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264730013539 homotrimer interaction site [polypeptide binding]; other site 264730013540 putative active site [active] 264730013541 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 264730013542 Family of unknown function (DUF633); Region: DUF633; pfam04816 264730013543 Thioredoxin; Region: Thioredoxin_4; cl17273 264730013544 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264730013545 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264730013546 substrate binding pocket [chemical binding]; other site 264730013547 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264730013548 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 264730013549 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 264730013550 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 264730013551 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 264730013552 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 264730013553 Abi-like protein; Region: Abi_2; pfam07751 264730013554 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264730013555 Cation efflux family; Region: Cation_efflux; cl00316 264730013556 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264730013557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730013558 putative DNA binding site [nucleotide binding]; other site 264730013559 putative Zn2+ binding site [ion binding]; other site 264730013560 AsnC family; Region: AsnC_trans_reg; pfam01037 264730013561 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 264730013562 pseudouridine synthase; Region: TIGR00093 264730013563 active site 264730013564 AMP nucleosidase; Provisional; Region: PRK08292 264730013565 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 264730013566 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 264730013567 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 264730013568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264730013569 active site 264730013570 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 264730013571 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 264730013572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730013573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730013574 dimer interface [polypeptide binding]; other site 264730013575 phosphorylation site [posttranslational modification] 264730013576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730013577 ATP binding site [chemical binding]; other site 264730013578 Mg2+ binding site [ion binding]; other site 264730013579 G-X-G motif; other site 264730013580 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 264730013581 dimer interface [polypeptide binding]; other site 264730013582 substrate binding site [chemical binding]; other site 264730013583 ATP binding site [chemical binding]; other site 264730013584 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 264730013585 thiamine phosphate binding site [chemical binding]; other site 264730013586 active site 264730013587 pyrophosphate binding site [ion binding]; other site 264730013588 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 264730013589 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730013590 inhibitor-cofactor binding pocket; inhibition site 264730013591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730013592 catalytic residue [active] 264730013593 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264730013594 Sel1-like repeats; Region: SEL1; smart00671 264730013595 Sel1-like repeats; Region: SEL1; smart00671 264730013596 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 264730013597 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 264730013598 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264730013599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730013600 FeS/SAM binding site; other site 264730013601 TRAM domain; Region: TRAM; pfam01938 264730013602 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 264730013603 PhoH-like protein; Region: PhoH; pfam02562 264730013604 metal-binding heat shock protein; Provisional; Region: PRK00016 264730013605 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 264730013606 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264730013607 Transporter associated domain; Region: CorC_HlyC; smart01091 264730013608 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 264730013609 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 264730013610 putative active site [active] 264730013611 catalytic triad [active] 264730013612 putative dimer interface [polypeptide binding]; other site 264730013613 Uncharacterized conserved protein [Function unknown]; Region: COG1434 264730013614 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 264730013615 putative active site [active] 264730013616 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 264730013617 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 264730013618 HIGH motif; other site 264730013619 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264730013620 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264730013621 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264730013622 active site 264730013623 KMSKS motif; other site 264730013624 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 264730013625 tRNA binding surface [nucleotide binding]; other site 264730013626 Lipopolysaccharide-assembly; Region: LptE; cl01125 264730013627 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 264730013628 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 264730013629 Domain of unknown function; Region: DUF331; cl01149 264730013630 Transglycosylase SLT domain; Region: SLT_2; pfam13406 264730013631 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264730013632 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264730013633 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 264730013634 lipoyl synthase; Provisional; Region: PRK05481 264730013635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730013636 FeS/SAM binding site; other site 264730013637 lipoate-protein ligase B; Provisional; Region: PRK14342 264730013638 hypothetical protein; Provisional; Region: PRK00341 264730013639 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 264730013640 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 264730013641 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 264730013642 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 264730013643 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 264730013644 Sporulation related domain; Region: SPOR; pfam05036 264730013645 Transglycosylase SLT domain; Region: SLT_2; pfam13406 264730013646 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264730013647 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264730013648 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 264730013649 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 264730013650 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264730013651 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264730013652 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 264730013653 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 264730013654 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 264730013655 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 264730013656 active site 264730013657 (T/H)XGH motif; other site 264730013658 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 264730013659 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 264730013660 putative catalytic cysteine [active] 264730013661 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 264730013662 active site 264730013663 DNA binding site [nucleotide binding] 264730013664 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264730013665 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 264730013666 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 264730013667 active site 264730013668 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264730013669 Predicted membrane protein [Function unknown]; Region: COG4655 264730013670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730013671 putative active site [active] 264730013672 heme pocket [chemical binding]; other site 264730013673 PAS fold; Region: PAS_3; pfam08447 264730013674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730013675 putative active site [active] 264730013676 heme pocket [chemical binding]; other site 264730013677 PAS domain; Region: PAS; smart00091 264730013678 PAS fold; Region: PAS_4; pfam08448 264730013679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730013680 dimer interface [polypeptide binding]; other site 264730013681 phosphorylation site [posttranslational modification] 264730013682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730013683 ATP binding site [chemical binding]; other site 264730013684 Mg2+ binding site [ion binding]; other site 264730013685 G-X-G motif; other site 264730013686 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 264730013687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264730013688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730013689 active site 264730013690 phosphorylation site [posttranslational modification] 264730013691 intermolecular recognition site; other site 264730013692 dimerization interface [polypeptide binding]; other site 264730013693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730013694 DNA binding residues [nucleotide binding] 264730013695 dimerization interface [polypeptide binding]; other site 264730013696 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 264730013697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730013698 active site 264730013699 phosphorylation site [posttranslational modification] 264730013700 intermolecular recognition site; other site 264730013701 dimerization interface [polypeptide binding]; other site 264730013702 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730013703 metal binding site [ion binding]; metal-binding site 264730013704 active site 264730013705 I-site; other site 264730013706 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 264730013707 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 264730013708 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 264730013709 nudix motif; other site 264730013710 translation initiation factor Sui1; Validated; Region: PRK06824 264730013711 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 264730013712 putative rRNA binding site [nucleotide binding]; other site 264730013713 arginine decarboxylase; Provisional; Region: PRK05354 264730013714 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 264730013715 dimer interface [polypeptide binding]; other site 264730013716 active site 264730013717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264730013718 catalytic residues [active] 264730013719 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 264730013720 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 264730013721 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 264730013722 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264730013723 substrate binding pocket [chemical binding]; other site 264730013724 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 264730013725 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 264730013726 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 264730013727 MG2 domain; Region: A2M_N; pfam01835 264730013728 Alpha-2-macroglobulin family; Region: A2M; pfam00207 264730013729 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 264730013730 surface patch; other site 264730013731 thioester region; other site 264730013732 specificity defining residues; other site 264730013733 penicillin-binding protein 1C; Provisional; Region: PRK11240 264730013734 Transglycosylase; Region: Transgly; pfam00912 264730013735 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264730013736 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 264730013737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730013738 active site 264730013739 phosphorylation site [posttranslational modification] 264730013740 intermolecular recognition site; other site 264730013741 dimerization interface [polypeptide binding]; other site 264730013742 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 264730013743 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 264730013744 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 264730013745 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 264730013746 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264730013747 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 264730013748 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 264730013749 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 264730013750 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 264730013751 ATP binding site [chemical binding]; other site 264730013752 Walker A motif; other site 264730013753 hexamer interface [polypeptide binding]; other site 264730013754 Walker B motif; other site 264730013755 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 264730013756 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264730013757 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 264730013758 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264730013759 TPR repeat; Region: TPR_11; pfam13414 264730013760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264730013761 binding surface 264730013762 TPR motif; other site 264730013763 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 264730013764 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 264730013765 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 264730013766 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 264730013767 DsbD alpha interface [polypeptide binding]; other site 264730013768 catalytic residues [active] 264730013769 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 264730013770 Dehydroquinase class II; Region: DHquinase_II; pfam01220 264730013771 trimer interface [polypeptide binding]; other site 264730013772 active site 264730013773 dimer interface [polypeptide binding]; other site 264730013774 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 264730013775 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264730013776 carboxyltransferase (CT) interaction site; other site 264730013777 biotinylation site [posttranslational modification]; other site 264730013778 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264730013779 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264730013780 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 264730013781 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264730013782 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 264730013783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730013784 S-adenosylmethionine binding site [chemical binding]; other site 264730013785 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 264730013786 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 264730013787 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 264730013788 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264730013789 FMN binding site [chemical binding]; other site 264730013790 active site 264730013791 catalytic residues [active] 264730013792 substrate binding site [chemical binding]; other site 264730013793 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 264730013794 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 264730013795 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 264730013796 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 264730013797 purine monophosphate binding site [chemical binding]; other site 264730013798 dimer interface [polypeptide binding]; other site 264730013799 putative catalytic residues [active] 264730013800 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 264730013801 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 264730013802 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 264730013803 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 264730013804 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 264730013805 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 264730013806 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 264730013807 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 264730013808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730013809 dimer interface [polypeptide binding]; other site 264730013810 phosphorylation site [posttranslational modification] 264730013811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730013812 ATP binding site [chemical binding]; other site 264730013813 Mg2+ binding site [ion binding]; other site 264730013814 G-X-G motif; other site 264730013815 Response regulator receiver domain; Region: Response_reg; pfam00072 264730013816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730013817 active site 264730013818 phosphorylation site [posttranslational modification] 264730013819 intermolecular recognition site; other site 264730013820 dimerization interface [polypeptide binding]; other site 264730013821 Response regulator receiver domain; Region: Response_reg; pfam00072 264730013822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730013823 active site 264730013824 phosphorylation site [posttranslational modification] 264730013825 intermolecular recognition site; other site 264730013826 dimerization interface [polypeptide binding]; other site 264730013827 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 264730013828 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 264730013829 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 264730013830 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 264730013831 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 264730013832 active site 264730013833 SAM binding site [chemical binding]; other site 264730013834 homodimer interface [polypeptide binding]; other site 264730013835 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 264730013836 active site 264730013837 SAM binding site [chemical binding]; other site 264730013838 homodimer interface [polypeptide binding]; other site 264730013839 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 264730013840 Precorrin-8X methylmutase; Region: CbiC; pfam02570 264730013841 precorrin-3B synthase; Region: CobG; TIGR02435 264730013842 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264730013843 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264730013844 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 264730013845 active site 264730013846 putative homodimer interface [polypeptide binding]; other site 264730013847 SAM binding site [chemical binding]; other site 264730013848 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 264730013849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730013850 S-adenosylmethionine binding site [chemical binding]; other site 264730013851 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 264730013852 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 264730013853 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 264730013854 Transposase IS200 like; Region: Y1_Tnp; pfam01797 264730013855 Protein of unknown function (DUF461); Region: DUF461; pfam04314 264730013856 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 264730013857 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 264730013858 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 264730013859 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 264730013860 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 264730013861 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 264730013862 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264730013863 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 264730013864 putative ligand binding site [chemical binding]; other site 264730013865 HEAT repeats; Region: HEAT_2; pfam13646 264730013866 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264730013867 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730013868 TM-ABC transporter signature motif; other site 264730013869 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264730013870 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264730013871 TM-ABC transporter signature motif; other site 264730013872 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 264730013873 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264730013874 Walker A/P-loop; other site 264730013875 ATP binding site [chemical binding]; other site 264730013876 Q-loop/lid; other site 264730013877 ABC transporter signature motif; other site 264730013878 Walker B; other site 264730013879 D-loop; other site 264730013880 H-loop/switch region; other site 264730013881 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 264730013882 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264730013883 Walker A/P-loop; other site 264730013884 ATP binding site [chemical binding]; other site 264730013885 Q-loop/lid; other site 264730013886 ABC transporter signature motif; other site 264730013887 Walker B; other site 264730013888 D-loop; other site 264730013889 H-loop/switch region; other site 264730013890 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 264730013891 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 264730013892 alpha-gamma subunit interface [polypeptide binding]; other site 264730013893 beta-gamma subunit interface [polypeptide binding]; other site 264730013894 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 264730013895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730013896 Coenzyme A binding pocket [chemical binding]; other site 264730013897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264730013898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730013899 Coenzyme A binding pocket [chemical binding]; other site 264730013900 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 264730013901 gamma-beta subunit interface [polypeptide binding]; other site 264730013902 alpha-beta subunit interface [polypeptide binding]; other site 264730013903 urease subunit alpha; Reviewed; Region: ureC; PRK13207 264730013904 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 264730013905 subunit interactions [polypeptide binding]; other site 264730013906 active site 264730013907 flap region; other site 264730013908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264730013909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730013910 dimer interface [polypeptide binding]; other site 264730013911 phosphorylation site [posttranslational modification] 264730013912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730013913 ATP binding site [chemical binding]; other site 264730013914 Mg2+ binding site [ion binding]; other site 264730013915 G-X-G motif; other site 264730013916 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 264730013917 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264730013918 HSP70 interaction site [polypeptide binding]; other site 264730013919 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264730013920 substrate binding site [polypeptide binding]; other site 264730013921 dimer interface [polypeptide binding]; other site 264730013922 putative chaperone; Provisional; Region: PRK11678 264730013923 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 264730013924 nucleotide binding site [chemical binding]; other site 264730013925 putative NEF/HSP70 interaction site [polypeptide binding]; other site 264730013926 SBD interface [polypeptide binding]; other site 264730013927 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 264730013928 psiF repeat; Region: PsiF_repeat; pfam07769 264730013929 psiF repeat; Region: PsiF_repeat; pfam07769 264730013930 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264730013931 EamA-like transporter family; Region: EamA; pfam00892 264730013932 EamA-like transporter family; Region: EamA; pfam00892 264730013933 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 264730013934 Protein of unknown function (DUF796); Region: DUF796; pfam05638 264730013935 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730013936 MULE transposase domain; Region: MULE; pfam10551 264730013937 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264730013938 Ferritin-like domain; Region: Ferritin; pfam00210 264730013939 dinuclear metal binding motif [ion binding]; other site 264730013940 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 264730013941 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 264730013942 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 264730013943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730013944 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 264730013945 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 264730013946 dimer interface [polypeptide binding]; other site 264730013947 catalytic residues [active] 264730013948 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 264730013949 UreF; Region: UreF; pfam01730 264730013950 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264730013951 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 264730013952 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 264730013953 dimerization interface [polypeptide binding]; other site 264730013954 active site 264730013955 thiamine monophosphate kinase; Provisional; Region: PRK05731 264730013956 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 264730013957 ATP binding site [chemical binding]; other site 264730013958 dimerization interface [polypeptide binding]; other site 264730013959 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 264730013960 putative RNA binding site [nucleotide binding]; other site 264730013961 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 264730013962 homopentamer interface [polypeptide binding]; other site 264730013963 active site 264730013964 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 264730013965 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 264730013966 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 264730013967 dimerization interface [polypeptide binding]; other site 264730013968 active site 264730013969 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 264730013970 Lumazine binding domain; Region: Lum_binding; pfam00677 264730013971 Lumazine binding domain; Region: Lum_binding; pfam00677 264730013972 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 264730013973 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 264730013974 catalytic motif [active] 264730013975 Zn binding site [ion binding]; other site 264730013976 RibD C-terminal domain; Region: RibD_C; cl17279 264730013977 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 264730013978 ATP cone domain; Region: ATP-cone; pfam03477 264730013979 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 264730013980 Predicted methyltransferase [General function prediction only]; Region: COG3897 264730013981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730013982 S-adenosylmethionine binding site [chemical binding]; other site 264730013983 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 264730013984 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 264730013985 SnoaL-like domain; Region: SnoaL_2; pfam12680 264730013986 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 264730013987 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264730013988 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264730013989 Walker A/P-loop; other site 264730013990 ATP binding site [chemical binding]; other site 264730013991 Q-loop/lid; other site 264730013992 ABC transporter signature motif; other site 264730013993 Walker B; other site 264730013994 D-loop; other site 264730013995 H-loop/switch region; other site 264730013996 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264730013997 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 264730013998 FtsX-like permease family; Region: FtsX; pfam02687 264730013999 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 264730014000 OmpW family; Region: OmpW; cl17427 264730014001 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264730014002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730014003 NAD(P) binding site [chemical binding]; other site 264730014004 active site 264730014005 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 264730014006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730014007 NAD(P) binding site [chemical binding]; other site 264730014008 active site 264730014009 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264730014010 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264730014011 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264730014012 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264730014013 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264730014014 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264730014015 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264730014016 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264730014017 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730014018 N-terminal plug; other site 264730014019 ligand-binding site [chemical binding]; other site 264730014020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730014021 PAS domain; Region: PAS_9; pfam13426 264730014022 putative active site [active] 264730014023 heme pocket [chemical binding]; other site 264730014024 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730014025 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730014026 metal binding site [ion binding]; metal-binding site 264730014027 active site 264730014028 I-site; other site 264730014029 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730014030 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 264730014031 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730014032 membrane-bound complex binding site; other site 264730014033 hinge residues; other site 264730014034 MarR family; Region: MarR_2; pfam12802 264730014035 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264730014036 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264730014037 nucleotide binding site [chemical binding]; other site 264730014038 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264730014039 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 264730014040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264730014041 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264730014042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730014043 dimer interface [polypeptide binding]; other site 264730014044 conserved gate region; other site 264730014045 putative PBP binding loops; other site 264730014046 ABC-ATPase subunit interface; other site 264730014047 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 264730014048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730014049 Walker A/P-loop; other site 264730014050 ATP binding site [chemical binding]; other site 264730014051 Q-loop/lid; other site 264730014052 ABC transporter signature motif; other site 264730014053 Walker B; other site 264730014054 D-loop; other site 264730014055 H-loop/switch region; other site 264730014056 TOBE domain; Region: TOBE_2; pfam08402 264730014057 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 264730014058 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 264730014059 putative active site [active] 264730014060 catalytic site [active] 264730014061 putative metal binding site [ion binding]; other site 264730014062 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 264730014063 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 264730014064 active site 264730014065 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 264730014066 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 264730014067 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264730014068 dimer interface [polypeptide binding]; other site 264730014069 ssDNA binding site [nucleotide binding]; other site 264730014070 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264730014071 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 264730014072 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 264730014073 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730014074 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 264730014075 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 264730014076 acyl-activating enzyme (AAE) consensus motif; other site 264730014077 AMP binding site [chemical binding]; other site 264730014078 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 264730014079 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 264730014080 active site 264730014081 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264730014082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264730014083 active site 264730014084 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730014085 AMP-binding enzyme; Region: AMP-binding; pfam00501 264730014086 acyl-activating enzyme (AAE) consensus motif; other site 264730014087 AMP binding site [chemical binding]; other site 264730014088 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 264730014089 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 264730014090 active site 264730014091 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730014092 sugar efflux transporter B; Provisional; Region: PRK15011 264730014093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730014094 putative substrate translocation pore; other site 264730014095 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 264730014096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730014097 FeS/SAM binding site; other site 264730014098 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 264730014099 Biofilm formation and stress response factor; Region: BsmA; pfam10014 264730014100 H+ Antiporter protein; Region: 2A0121; TIGR00900 264730014101 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_12; cd04670 264730014102 nudix motif; other site 264730014103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 264730014104 Helix-turn-helix domain; Region: HTH_38; pfam13936 264730014105 DNA-binding interface [nucleotide binding]; DNA binding site 264730014106 haemagglutination activity domain; Region: Haemagg_act; pfam05860 264730014107 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 264730014108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730014109 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730014110 putative substrate translocation pore; other site 264730014111 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 264730014112 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264730014113 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264730014114 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 264730014115 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 264730014116 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 264730014117 heme binding site [chemical binding]; other site 264730014118 ferroxidase pore; other site 264730014119 ferroxidase diiron center [ion binding]; other site 264730014120 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 264730014121 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 264730014122 tetramer interface [polypeptide binding]; other site 264730014123 heme binding pocket [chemical binding]; other site 264730014124 NADPH binding site [chemical binding]; other site 264730014125 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 264730014126 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 264730014127 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 264730014128 alphaNTD homodimer interface [polypeptide binding]; other site 264730014129 alphaNTD - beta interaction site [polypeptide binding]; other site 264730014130 alphaNTD - beta' interaction site [polypeptide binding]; other site 264730014131 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 264730014132 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 264730014133 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 264730014134 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264730014135 RNA binding surface [nucleotide binding]; other site 264730014136 30S ribosomal protein S11; Validated; Region: PRK05309 264730014137 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 264730014138 30S ribosomal protein S13; Region: bact_S13; TIGR03631 264730014139 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 264730014140 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 264730014141 SecY translocase; Region: SecY; pfam00344 264730014142 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 264730014143 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 264730014144 23S rRNA binding site [nucleotide binding]; other site 264730014145 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 264730014146 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 264730014147 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 264730014148 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 264730014149 5S rRNA interface [nucleotide binding]; other site 264730014150 23S rRNA interface [nucleotide binding]; other site 264730014151 L5 interface [polypeptide binding]; other site 264730014152 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 264730014153 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264730014154 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264730014155 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 264730014156 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 264730014157 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 264730014158 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 264730014159 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 264730014160 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 264730014161 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 264730014162 RNA binding site [nucleotide binding]; other site 264730014163 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 264730014164 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 264730014165 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 264730014166 23S rRNA interface [nucleotide binding]; other site 264730014167 putative translocon interaction site; other site 264730014168 signal recognition particle (SRP54) interaction site; other site 264730014169 L23 interface [polypeptide binding]; other site 264730014170 trigger factor interaction site; other site 264730014171 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 264730014172 23S rRNA interface [nucleotide binding]; other site 264730014173 5S rRNA interface [nucleotide binding]; other site 264730014174 putative antibiotic binding site [chemical binding]; other site 264730014175 L25 interface [polypeptide binding]; other site 264730014176 L27 interface [polypeptide binding]; other site 264730014177 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 264730014178 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 264730014179 G-X-X-G motif; other site 264730014180 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 264730014181 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 264730014182 protein-rRNA interface [nucleotide binding]; other site 264730014183 putative translocon binding site; other site 264730014184 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 264730014185 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 264730014186 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 264730014187 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 264730014188 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 264730014189 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 264730014190 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 264730014191 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 264730014192 elongation factor Tu; Reviewed; Region: PRK00049 264730014193 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 264730014194 G1 box; other site 264730014195 GEF interaction site [polypeptide binding]; other site 264730014196 GTP/Mg2+ binding site [chemical binding]; other site 264730014197 Switch I region; other site 264730014198 G2 box; other site 264730014199 G3 box; other site 264730014200 Switch II region; other site 264730014201 G4 box; other site 264730014202 G5 box; other site 264730014203 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 264730014204 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 264730014205 Antibiotic Binding Site [chemical binding]; other site 264730014206 elongation factor G; Reviewed; Region: PRK00007 264730014207 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 264730014208 G1 box; other site 264730014209 putative GEF interaction site [polypeptide binding]; other site 264730014210 GTP/Mg2+ binding site [chemical binding]; other site 264730014211 Switch I region; other site 264730014212 G2 box; other site 264730014213 G3 box; other site 264730014214 Switch II region; other site 264730014215 G4 box; other site 264730014216 G5 box; other site 264730014217 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264730014218 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264730014219 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264730014220 30S ribosomal protein S7; Validated; Region: PRK05302 264730014221 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 264730014222 S17 interaction site [polypeptide binding]; other site 264730014223 S8 interaction site; other site 264730014224 16S rRNA interaction site [nucleotide binding]; other site 264730014225 streptomycin interaction site [chemical binding]; other site 264730014226 23S rRNA interaction site [nucleotide binding]; other site 264730014227 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 264730014228 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 264730014229 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 264730014230 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 264730014231 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 264730014232 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 264730014233 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 264730014234 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264730014235 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 264730014236 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264730014237 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 264730014238 DNA binding site [nucleotide binding] 264730014239 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 264730014240 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 264730014241 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 264730014242 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 264730014243 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264730014244 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 264730014245 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264730014246 RPB3 interaction site [polypeptide binding]; other site 264730014247 RPB1 interaction site [polypeptide binding]; other site 264730014248 RPB11 interaction site [polypeptide binding]; other site 264730014249 RPB10 interaction site [polypeptide binding]; other site 264730014250 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 264730014251 peripheral dimer interface [polypeptide binding]; other site 264730014252 core dimer interface [polypeptide binding]; other site 264730014253 L10 interface [polypeptide binding]; other site 264730014254 L11 interface [polypeptide binding]; other site 264730014255 putative EF-Tu interaction site [polypeptide binding]; other site 264730014256 putative EF-G interaction site [polypeptide binding]; other site 264730014257 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 264730014258 23S rRNA interface [nucleotide binding]; other site 264730014259 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 264730014260 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 264730014261 mRNA/rRNA interface [nucleotide binding]; other site 264730014262 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 264730014263 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 264730014264 23S rRNA interface [nucleotide binding]; other site 264730014265 L7/L12 interface [polypeptide binding]; other site 264730014266 putative thiostrepton binding site; other site 264730014267 L25 interface [polypeptide binding]; other site 264730014268 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 264730014269 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 264730014270 putative homodimer interface [polypeptide binding]; other site 264730014271 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 264730014272 heterodimer interface [polypeptide binding]; other site 264730014273 homodimer interface [polypeptide binding]; other site 264730014274 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 264730014275 pantothenate kinase; Reviewed; Region: PRK13322 264730014276 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 264730014277 Biotin operon repressor [Transcription]; Region: BirA; COG1654 264730014278 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 264730014279 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 264730014280 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264730014281 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 264730014282 tetrameric interface [polypeptide binding]; other site 264730014283 NAD binding site [chemical binding]; other site 264730014284 catalytic residues [active] 264730014285 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 264730014286 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730014287 inhibitor-cofactor binding pocket; inhibition site 264730014288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730014289 catalytic residue [active] 264730014290 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730014291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730014292 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264730014293 dimerization interface [polypeptide binding]; other site 264730014294 xanthine permease; Region: pbuX; TIGR03173 264730014295 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 264730014296 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 264730014297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730014298 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 264730014299 Uncharacterized conserved protein [Function unknown]; Region: COG1739 264730014300 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 264730014301 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 264730014302 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 264730014303 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264730014304 Walker A/P-loop; other site 264730014305 ATP binding site [chemical binding]; other site 264730014306 Q-loop/lid; other site 264730014307 ABC transporter signature motif; other site 264730014308 Walker B; other site 264730014309 D-loop; other site 264730014310 H-loop/switch region; other site 264730014311 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264730014312 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730014313 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264730014314 TM-ABC transporter signature motif; other site 264730014315 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264730014316 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264730014317 TM-ABC transporter signature motif; other site 264730014318 short chain dehydrogenase; Provisional; Region: PRK08177 264730014319 C factor cell-cell signaling protein; Provisional; Region: PRK09009 264730014320 NAD(P) binding site [chemical binding]; other site 264730014321 active site 264730014322 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 264730014323 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 264730014324 active site 264730014325 putative substrate binding pocket [chemical binding]; other site 264730014326 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 264730014327 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 264730014328 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 264730014329 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 264730014330 siderophore binding site; other site 264730014331 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 264730014332 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264730014333 putative PBP binding regions; other site 264730014334 ABC-ATPase subunit interface; other site 264730014335 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 264730014336 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264730014337 ABC-ATPase subunit interface; other site 264730014338 dimer interface [polypeptide binding]; other site 264730014339 putative PBP binding regions; other site 264730014340 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 264730014341 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264730014342 Walker A/P-loop; other site 264730014343 ATP binding site [chemical binding]; other site 264730014344 Q-loop/lid; other site 264730014345 ABC transporter signature motif; other site 264730014346 Walker B; other site 264730014347 D-loop; other site 264730014348 H-loop/switch region; other site 264730014349 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 264730014350 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 264730014351 putative ligand binding site [chemical binding]; other site 264730014352 oxidase reductase; Provisional; Region: PTZ00273 264730014353 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 264730014354 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 264730014355 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 264730014356 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 264730014357 active site 264730014358 purine riboside binding site [chemical binding]; other site 264730014359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730014360 putative DNA binding site [nucleotide binding]; other site 264730014361 putative Zn2+ binding site [ion binding]; other site 264730014362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730014363 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264730014364 putative effector binding pocket; other site 264730014365 dimerization interface [polypeptide binding]; other site 264730014366 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 264730014367 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 264730014368 putative NAD(P) binding site [chemical binding]; other site 264730014369 dimer interface [polypeptide binding]; other site 264730014370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730014371 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 264730014372 putative substrate translocation pore; other site 264730014373 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264730014374 metal-binding site [ion binding] 264730014375 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264730014376 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264730014377 metal-binding site [ion binding] 264730014378 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264730014379 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264730014380 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 264730014381 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 264730014382 DNA binding residues [nucleotide binding] 264730014383 dimer interface [polypeptide binding]; other site 264730014384 copper binding site [ion binding]; other site 264730014385 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 264730014386 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 264730014387 ATP binding site [chemical binding]; other site 264730014388 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264730014389 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264730014390 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 264730014391 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 264730014392 Protein of unknown function (DUF726); Region: DUF726; pfam05277 264730014393 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 264730014394 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264730014395 dimer interface [polypeptide binding]; other site 264730014396 active site 264730014397 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 264730014398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730014399 NAD(P) binding site [chemical binding]; other site 264730014400 active site 264730014401 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264730014402 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264730014403 active site 2 [active] 264730014404 active site 1 [active] 264730014405 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 264730014406 homodimer interface [polypeptide binding]; other site 264730014407 chemical substrate binding site [chemical binding]; other site 264730014408 oligomer interface [polypeptide binding]; other site 264730014409 metal binding site [ion binding]; metal-binding site 264730014410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730014411 S-adenosylmethionine binding site [chemical binding]; other site 264730014412 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 264730014413 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 264730014414 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 264730014415 LrgB-like family; Region: LrgB; pfam04172 264730014416 LrgA family; Region: LrgA; cl00608 264730014417 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 264730014418 putative active site [active] 264730014419 putative catalytic site [active] 264730014420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 264730014421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 264730014422 Peptidase C13 family; Region: Peptidase_C13; cl02159 264730014423 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 264730014424 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 264730014425 NAD binding site [chemical binding]; other site 264730014426 active site 264730014427 aromatic acid decarboxylase; Validated; Region: PRK05920 264730014428 Flavoprotein; Region: Flavoprotein; pfam02441 264730014429 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 264730014430 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264730014431 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264730014432 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264730014433 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264730014434 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264730014435 NAD(P) binding site [chemical binding]; other site 264730014436 catalytic residues [active] 264730014437 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 264730014438 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 264730014439 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 264730014440 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264730014441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730014442 Coenzyme A binding pocket [chemical binding]; other site 264730014443 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 264730014444 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264730014445 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 264730014446 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 264730014447 dimer interface [polypeptide binding]; other site 264730014448 substrate binding site [chemical binding]; other site 264730014449 metal binding sites [ion binding]; metal-binding site 264730014450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730014451 non-specific DNA binding site [nucleotide binding]; other site 264730014452 salt bridge; other site 264730014453 sequence-specific DNA binding site [nucleotide binding]; other site 264730014454 Predicted transcriptional regulator [Transcription]; Region: COG2932 264730014455 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264730014456 Catalytic site [active] 264730014457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730014458 non-specific DNA binding site [nucleotide binding]; other site 264730014459 salt bridge; other site 264730014460 sequence-specific DNA binding site [nucleotide binding]; other site 264730014461 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 264730014462 Cupin domain; Region: Cupin_2; cl17218 264730014463 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 264730014464 Ligand binding site; other site 264730014465 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 264730014466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730014467 motif II; other site 264730014468 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584 264730014469 putative active site [active] 264730014470 catalytic site [active] 264730014471 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 264730014472 Ligand binding site; other site 264730014473 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 264730014474 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 264730014475 Walker A/P-loop; other site 264730014476 ATP binding site [chemical binding]; other site 264730014477 Q-loop/lid; other site 264730014478 ABC transporter signature motif; other site 264730014479 Walker B; other site 264730014480 D-loop; other site 264730014481 H-loop/switch region; other site 264730014482 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 264730014483 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730014484 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730014485 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730014486 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 264730014487 GTP/Mg2+ binding site [chemical binding]; other site 264730014488 G5 box; other site 264730014489 AAA domain; Region: AAA_21; pfam13304 264730014490 G1 box; other site 264730014491 Switch I region; other site 264730014492 G2 box; other site 264730014493 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730014494 MULE transposase domain; Region: MULE; pfam10551 264730014495 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 264730014496 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264730014497 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264730014498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730014499 Helix-turn-helix domain; Region: HTH_18; pfam12833 264730014500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730014501 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264730014502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730014503 non-specific DNA binding site [nucleotide binding]; other site 264730014504 salt bridge; other site 264730014505 sequence-specific DNA binding site [nucleotide binding]; other site 264730014506 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 264730014507 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 264730014508 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 264730014509 acyl-activating enzyme (AAE) consensus motif; other site 264730014510 AMP binding site [chemical binding]; other site 264730014511 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 264730014512 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 264730014513 putative trimer interface [polypeptide binding]; other site 264730014514 putative CoA binding site [chemical binding]; other site 264730014515 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 264730014516 Fic family protein [Function unknown]; Region: COG3177 264730014517 Fic/DOC family; Region: Fic; pfam02661 264730014518 Predicted membrane protein [Function unknown]; Region: COG1289 264730014519 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264730014520 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264730014521 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 264730014522 putative DNA binding site [nucleotide binding]; other site 264730014523 putative Zn2+ binding site [ion binding]; other site 264730014524 AsnC family; Region: AsnC_trans_reg; pfam01037 264730014525 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 264730014526 Predicted amidohydrolase [General function prediction only]; Region: COG0388 264730014527 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 264730014528 putative active site [active] 264730014529 catalytic triad [active] 264730014530 putative dimer interface [polypeptide binding]; other site 264730014531 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 264730014532 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264730014533 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264730014534 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264730014535 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 264730014536 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 264730014537 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 264730014538 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 264730014539 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 264730014540 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 264730014541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730014542 FeS/SAM binding site; other site 264730014543 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 264730014544 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730014545 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264730014546 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 264730014547 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264730014548 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264730014549 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264730014550 active site 264730014551 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264730014552 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730014553 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730014554 metal binding site [ion binding]; metal-binding site 264730014555 active site 264730014556 I-site; other site 264730014557 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264730014558 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264730014559 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264730014560 active site 264730014561 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264730014562 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 264730014563 AAA domain; Region: AAA_26; pfam13500 264730014564 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 264730014565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730014566 S-adenosylmethionine binding site [chemical binding]; other site 264730014567 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 264730014568 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 264730014569 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 264730014570 substrate-cofactor binding pocket; other site 264730014571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730014572 catalytic residue [active] 264730014573 biotin synthase; Provisional; Region: PRK15108 264730014574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264730014575 FeS/SAM binding site; other site 264730014576 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 264730014577 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 264730014578 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264730014579 active site 264730014580 TOBE domain; Region: TOBE; cl01440 264730014581 TOBE domain; Region: TOBE; cl01440 264730014582 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 264730014583 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 264730014584 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264730014585 active site 264730014586 metal binding site [ion binding]; metal-binding site 264730014587 hexamer interface [polypeptide binding]; other site 264730014588 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 264730014589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730014590 Walker A/P-loop; other site 264730014591 ATP binding site [chemical binding]; other site 264730014592 Q-loop/lid; other site 264730014593 ABC transporter signature motif; other site 264730014594 Walker B; other site 264730014595 D-loop; other site 264730014596 H-loop/switch region; other site 264730014597 TOBE domain; Region: TOBE_2; pfam08402 264730014598 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264730014599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730014600 dimer interface [polypeptide binding]; other site 264730014601 conserved gate region; other site 264730014602 putative PBP binding loops; other site 264730014603 ABC-ATPase subunit interface; other site 264730014604 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 264730014605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730014606 dimer interface [polypeptide binding]; other site 264730014607 conserved gate region; other site 264730014608 putative PBP binding loops; other site 264730014609 ABC-ATPase subunit interface; other site 264730014610 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 264730014611 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 264730014612 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264730014613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264730014614 DNA binding site [nucleotide binding] 264730014615 domain linker motif; other site 264730014616 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 264730014617 putative dimerization interface [polypeptide binding]; other site 264730014618 putative ligand binding site [chemical binding]; other site 264730014619 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 264730014620 serine/threonine protein kinase; Provisional; Region: PRK11768 264730014621 Predicted permeases [General function prediction only]; Region: RarD; COG2962 264730014622 ACT domain; Region: ACT_6; pfam13740 264730014623 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 264730014624 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 264730014625 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 264730014626 active site 264730014627 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730014628 MULE transposase domain; Region: MULE; pfam10551 264730014629 Response regulator receiver domain; Region: Response_reg; pfam00072 264730014630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730014631 active site 264730014632 phosphorylation site [posttranslational modification] 264730014633 intermolecular recognition site; other site 264730014634 dimerization interface [polypeptide binding]; other site 264730014635 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 264730014636 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264730014637 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 264730014638 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 264730014639 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264730014640 metal binding triad; other site 264730014641 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264730014642 active site 264730014643 catalytic site [active] 264730014644 substrate binding site [chemical binding]; other site 264730014645 Cell division protein ZapA; Region: ZapA; pfam05164 264730014646 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730014647 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730014648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730014649 dimerization interface [polypeptide binding]; other site 264730014650 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730014651 dimer interface [polypeptide binding]; other site 264730014652 putative CheW interface [polypeptide binding]; other site 264730014653 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264730014654 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 264730014655 conserved cys residue [active] 264730014656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730014657 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 264730014658 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 264730014659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730014660 dimer interface [polypeptide binding]; other site 264730014661 conserved gate region; other site 264730014662 putative PBP binding loops; other site 264730014663 ABC-ATPase subunit interface; other site 264730014664 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 264730014665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730014666 Walker A/P-loop; other site 264730014667 ATP binding site [chemical binding]; other site 264730014668 Q-loop/lid; other site 264730014669 ABC transporter signature motif; other site 264730014670 Walker B; other site 264730014671 D-loop; other site 264730014672 H-loop/switch region; other site 264730014673 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 264730014674 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264730014675 dimer interface [polypeptide binding]; other site 264730014676 active site 264730014677 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264730014678 folate binding site [chemical binding]; other site 264730014679 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 264730014680 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264730014681 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 264730014682 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 264730014683 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 264730014684 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264730014685 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 264730014686 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 264730014687 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 264730014688 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 264730014689 putative active site [active] 264730014690 putative substrate binding site [chemical binding]; other site 264730014691 putative cosubstrate binding site; other site 264730014692 catalytic site [active] 264730014693 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 264730014694 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 264730014695 NAD binding site [chemical binding]; other site 264730014696 catalytic Zn binding site [ion binding]; other site 264730014697 structural Zn binding site [ion binding]; other site 264730014698 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730014699 MULE transposase domain; Region: MULE; pfam10551 264730014700 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 264730014701 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264730014702 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 264730014703 putative acyl-acceptor binding pocket; other site 264730014704 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 264730014705 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264730014706 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264730014707 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 264730014708 N-terminal domain interface [polypeptide binding]; other site 264730014709 dimer interface [polypeptide binding]; other site 264730014710 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 264730014711 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 264730014712 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 264730014713 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 264730014714 FecR protein; Region: FecR; pfam04773 264730014715 RNA polymerase sigma factor; Reviewed; Region: PRK12523 264730014716 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730014717 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730014718 DNA binding residues [nucleotide binding] 264730014719 choline dehydrogenase; Validated; Region: PRK02106 264730014720 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264730014721 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 264730014722 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264730014723 NAD(P) binding site [chemical binding]; other site 264730014724 catalytic residues [active] 264730014725 transcriptional regulator BetI; Validated; Region: PRK00767 264730014726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730014727 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 264730014728 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 264730014729 G1 box; other site 264730014730 GTP/Mg2+ binding site [chemical binding]; other site 264730014731 G2 box; other site 264730014732 Switch I region; other site 264730014733 G3 box; other site 264730014734 Switch II region; other site 264730014735 G4 box; other site 264730014736 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 264730014737 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 264730014738 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 264730014739 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 264730014740 folate binding site [chemical binding]; other site 264730014741 NADP+ binding site [chemical binding]; other site 264730014742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730014743 S-adenosylmethionine binding site [chemical binding]; other site 264730014744 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 264730014745 ThiS interaction site; other site 264730014746 putative active site [active] 264730014747 tetramer interface [polypeptide binding]; other site 264730014748 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 264730014749 thiS-thiF/thiG interaction site; other site 264730014750 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 264730014751 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 264730014752 Transglycosylase; Region: Transgly; cl17702 264730014753 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 264730014754 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264730014755 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264730014756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264730014757 DNA binding residues [nucleotide binding] 264730014758 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 264730014759 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 264730014760 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 264730014761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730014762 Walker A/P-loop; other site 264730014763 ATP binding site [chemical binding]; other site 264730014764 Q-loop/lid; other site 264730014765 ABC transporter signature motif; other site 264730014766 Walker B; other site 264730014767 D-loop; other site 264730014768 H-loop/switch region; other site 264730014769 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 264730014770 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 264730014771 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264730014772 P loop; other site 264730014773 GTP binding site [chemical binding]; other site 264730014774 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264730014775 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264730014776 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264730014777 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264730014778 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264730014779 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264730014780 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 264730014781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730014782 S-adenosylmethionine binding site [chemical binding]; other site 264730014783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730014784 AAA domain; Region: AAA_21; pfam13304 264730014785 Walker A/P-loop; other site 264730014786 ATP binding site [chemical binding]; other site 264730014787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 264730014788 ABC transporter signature motif; other site 264730014789 Walker B; other site 264730014790 D-loop; other site 264730014791 H-loop/switch region; other site 264730014792 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 264730014793 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 264730014794 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 264730014795 active site residue [active] 264730014796 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 264730014797 active site residue [active] 264730014798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730014799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730014800 Bacterial transcriptional repressor; Region: TetR; pfam13972 264730014801 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 264730014802 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 264730014803 active site 264730014804 (T/H)XGH motif; other site 264730014805 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264730014806 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 264730014807 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 264730014808 DNA binding site [nucleotide binding] 264730014809 catalytic residue [active] 264730014810 H2TH interface [polypeptide binding]; other site 264730014811 putative catalytic residues [active] 264730014812 turnover-facilitating residue; other site 264730014813 intercalation triad [nucleotide binding]; other site 264730014814 8OG recognition residue [nucleotide binding]; other site 264730014815 putative reading head residues; other site 264730014816 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 264730014817 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264730014818 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 264730014819 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 264730014820 intracellular protease, PfpI family; Region: PfpI; TIGR01382 264730014821 proposed catalytic triad [active] 264730014822 conserved cys residue [active] 264730014823 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 264730014824 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 264730014825 putative RNA binding site [nucleotide binding]; other site 264730014826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730014827 S-adenosylmethionine binding site [chemical binding]; other site 264730014828 conjugal transfer protein TrbP; Provisional; Region: PRK13882 264730014829 TraX protein; Region: TraX; pfam05857 264730014830 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 264730014831 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 264730014832 putative transporter; Provisional; Region: PRK10504 264730014833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730014834 putative substrate translocation pore; other site 264730014835 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 264730014836 GAF domain; Region: GAF; pfam01590 264730014837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730014838 PAS domain; Region: PAS_9; pfam13426 264730014839 putative active site [active] 264730014840 heme pocket [chemical binding]; other site 264730014841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264730014842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730014843 metal binding site [ion binding]; metal-binding site 264730014844 active site 264730014845 I-site; other site 264730014846 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730014847 methionine sulfoxide reductase A; Provisional; Region: PRK00058 264730014848 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 264730014849 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264730014850 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 264730014851 FAD binding pocket [chemical binding]; other site 264730014852 FAD binding motif [chemical binding]; other site 264730014853 phosphate binding motif [ion binding]; other site 264730014854 beta-alpha-beta structure motif; other site 264730014855 NAD binding pocket [chemical binding]; other site 264730014856 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264730014857 catalytic loop [active] 264730014858 iron binding site [ion binding]; other site 264730014859 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264730014860 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 264730014861 [2Fe-2S] cluster binding site [ion binding]; other site 264730014862 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 264730014863 putative alpha subunit interface [polypeptide binding]; other site 264730014864 putative active site [active] 264730014865 putative substrate binding site [chemical binding]; other site 264730014866 Fe binding site [ion binding]; other site 264730014867 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 264730014868 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 264730014869 putative active site [active] 264730014870 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264730014871 Interdomain contacts; other site 264730014872 Cytokine receptor motif; other site 264730014873 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264730014874 Interdomain contacts; other site 264730014875 Cytokine receptor motif; other site 264730014876 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 264730014877 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264730014878 Interdomain contacts; other site 264730014879 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 264730014880 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264730014881 Ligand Binding Site [chemical binding]; other site 264730014882 Electron transfer flavoprotein domain; Region: ETF; pfam01012 264730014883 Ligand Binding Site [chemical binding]; other site 264730014884 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 264730014885 Electron transfer flavoprotein domain; Region: ETF; smart00893 264730014886 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 264730014887 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 264730014888 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264730014889 Cysteine-rich domain; Region: CCG; pfam02754 264730014890 Cysteine-rich domain; Region: CCG; pfam02754 264730014891 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 264730014892 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 264730014893 putative active site [active] 264730014894 putative FMN binding site [chemical binding]; other site 264730014895 putative substrate binding site [chemical binding]; other site 264730014896 putative catalytic residue [active] 264730014897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264730014898 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 264730014899 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 264730014900 active site 264730014901 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 264730014902 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 264730014903 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 264730014904 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 264730014905 intersubunit interface [polypeptide binding]; other site 264730014906 active site 264730014907 zinc binding site [ion binding]; other site 264730014908 Na+ binding site [ion binding]; other site 264730014909 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 264730014910 Phosphoglycerate kinase; Region: PGK; pfam00162 264730014911 substrate binding site [chemical binding]; other site 264730014912 hinge regions; other site 264730014913 ADP binding site [chemical binding]; other site 264730014914 catalytic site [active] 264730014915 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 264730014916 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 264730014917 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 264730014918 transketolase; Reviewed; Region: PRK12753 264730014919 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 264730014920 TPP-binding site [chemical binding]; other site 264730014921 dimer interface [polypeptide binding]; other site 264730014922 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264730014923 PYR/PP interface [polypeptide binding]; other site 264730014924 dimer interface [polypeptide binding]; other site 264730014925 TPP binding site [chemical binding]; other site 264730014926 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264730014927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730014928 putative DNA binding site [nucleotide binding]; other site 264730014929 putative Zn2+ binding site [ion binding]; other site 264730014930 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264730014931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730014932 S-adenosylmethionine binding site [chemical binding]; other site 264730014933 S-adenosylmethionine synthetase; Validated; Region: PRK05250 264730014934 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 264730014935 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 264730014936 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 264730014937 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 264730014938 MAPEG family; Region: MAPEG; cl09190 264730014939 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264730014940 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730014941 dimerization interface [polypeptide binding]; other site 264730014942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730014943 dimer interface [polypeptide binding]; other site 264730014944 phosphorylation site [posttranslational modification] 264730014945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730014946 ATP binding site [chemical binding]; other site 264730014947 Mg2+ binding site [ion binding]; other site 264730014948 G-X-G motif; other site 264730014949 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 264730014950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730014951 active site 264730014952 phosphorylation site [posttranslational modification] 264730014953 intermolecular recognition site; other site 264730014954 dimerization interface [polypeptide binding]; other site 264730014955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730014956 DNA binding site [nucleotide binding] 264730014957 Outer membrane efflux protein; Region: OEP; pfam02321 264730014958 Outer membrane efflux protein; Region: OEP; pfam02321 264730014959 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 264730014960 HlyD family secretion protein; Region: HlyD_3; pfam13437 264730014961 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 264730014962 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 264730014963 PAAR motif; Region: PAAR_motif; pfam05488 264730014964 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264730014965 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 264730014966 RHS Repeat; Region: RHS_repeat; cl11982 264730014967 RHS protein; Region: RHS; pfam03527 264730014968 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730014969 RHS protein; Region: RHS; pfam03527 264730014970 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730014971 MULE transposase domain; Region: MULE; pfam10551 264730014972 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 264730014973 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264730014974 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 264730014975 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264730014976 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264730014977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264730014978 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 264730014979 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 264730014980 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264730014981 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 264730014982 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264730014983 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 264730014984 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 264730014985 G1 box; other site 264730014986 putative GEF interaction site [polypeptide binding]; other site 264730014987 GTP/Mg2+ binding site [chemical binding]; other site 264730014988 Switch I region; other site 264730014989 G2 box; other site 264730014990 G3 box; other site 264730014991 Switch II region; other site 264730014992 G4 box; other site 264730014993 G5 box; other site 264730014994 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 264730014995 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 264730014996 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 264730014997 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 264730014998 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 264730014999 Ligand Binding Site [chemical binding]; other site 264730015000 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 264730015001 glutamine synthetase; Provisional; Region: glnA; PRK09469 264730015002 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264730015003 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264730015004 Cupin domain; Region: Cupin_2; pfam07883 264730015005 chorismate mutase; Provisional; Region: PRK09269 264730015006 Chorismate mutase type II; Region: CM_2; cl00693 264730015007 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 264730015008 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 264730015009 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264730015010 PAS domain; Region: PAS; smart00091 264730015011 putative active site [active] 264730015012 heme pocket [chemical binding]; other site 264730015013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730015014 dimer interface [polypeptide binding]; other site 264730015015 phosphorylation site [posttranslational modification] 264730015016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730015017 ATP binding site [chemical binding]; other site 264730015018 Mg2+ binding site [ion binding]; other site 264730015019 G-X-G motif; other site 264730015020 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 264730015021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730015022 active site 264730015023 phosphorylation site [posttranslational modification] 264730015024 intermolecular recognition site; other site 264730015025 dimerization interface [polypeptide binding]; other site 264730015026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730015027 Walker A motif; other site 264730015028 ATP binding site [chemical binding]; other site 264730015029 Walker B motif; other site 264730015030 arginine finger; other site 264730015031 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264730015032 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264730015033 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264730015034 active site 264730015035 catalytic tetrad [active] 264730015036 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264730015037 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730015038 substrate binding pocket [chemical binding]; other site 264730015039 membrane-bound complex binding site; other site 264730015040 hinge residues; other site 264730015041 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 264730015042 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 264730015043 active site 264730015044 non-prolyl cis peptide bond; other site 264730015045 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264730015046 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730015047 N-terminal plug; other site 264730015048 ligand-binding site [chemical binding]; other site 264730015049 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264730015050 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264730015051 DNA binding site [nucleotide binding] 264730015052 domain linker motif; other site 264730015053 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 264730015054 putative dimerization interface [polypeptide binding]; other site 264730015055 putative ligand binding site [chemical binding]; other site 264730015056 BCCT family transporter; Region: BCCT; cl00569 264730015057 urocanate hydratase; Provisional; Region: PRK05414 264730015058 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 264730015059 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264730015060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015061 dimer interface [polypeptide binding]; other site 264730015062 conserved gate region; other site 264730015063 putative PBP binding loops; other site 264730015064 ABC-ATPase subunit interface; other site 264730015065 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264730015066 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 264730015067 Walker A/P-loop; other site 264730015068 ATP binding site [chemical binding]; other site 264730015069 Q-loop/lid; other site 264730015070 ABC transporter signature motif; other site 264730015071 Walker B; other site 264730015072 D-loop; other site 264730015073 H-loop/switch region; other site 264730015074 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 264730015075 active sites [active] 264730015076 tetramer interface [polypeptide binding]; other site 264730015077 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 264730015078 active sites [active] 264730015079 tetramer interface [polypeptide binding]; other site 264730015080 putative proline-specific permease; Provisional; Region: proY; PRK10580 264730015081 Spore germination protein; Region: Spore_permease; cl17796 264730015082 imidazolonepropionase; Validated; Region: PRK09356 264730015083 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 264730015084 active site 264730015085 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264730015086 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264730015087 metal-binding site [ion binding] 264730015088 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264730015089 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 264730015090 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 264730015091 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 264730015092 DNA binding residues [nucleotide binding] 264730015093 dimer interface [polypeptide binding]; other site 264730015094 putative metal binding site [ion binding]; other site 264730015095 thymidylate synthase; Provisional; Region: thyA; PRK13821 264730015096 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 264730015097 dimerization interface [polypeptide binding]; other site 264730015098 active site 264730015099 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 264730015100 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 264730015101 GAF domain; Region: GAF; pfam01590 264730015102 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 264730015103 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264730015104 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264730015105 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 264730015106 putative active site [active] 264730015107 Ap4A binding site [chemical binding]; other site 264730015108 nudix motif; other site 264730015109 putative metal binding site [ion binding]; other site 264730015110 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 264730015111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730015112 motif II; other site 264730015113 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 264730015114 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264730015115 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 264730015116 putative Ile/Val binding site [chemical binding]; other site 264730015117 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 264730015118 putative Ile/Val binding site [chemical binding]; other site 264730015119 threonine dehydratase; Reviewed; Region: PRK09224 264730015120 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 264730015121 tetramer interface [polypeptide binding]; other site 264730015122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730015123 catalytic residue [active] 264730015124 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 264730015125 putative Ile/Val binding site [chemical binding]; other site 264730015126 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 264730015127 putative Ile/Val binding site [chemical binding]; other site 264730015128 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 264730015129 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264730015130 active site 264730015131 dimer interface [polypeptide binding]; other site 264730015132 SdiA-regulated; Region: SdiA-regulated; pfam06977 264730015133 SdiA-regulated; Region: SdiA-regulated; cd09971 264730015134 putative active site [active] 264730015135 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264730015136 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264730015137 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264730015138 FAD binding domain; Region: FAD_binding_4; pfam01565 264730015139 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 264730015140 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 264730015141 ligand binding site [chemical binding]; other site 264730015142 NAD binding site [chemical binding]; other site 264730015143 tetramer interface [polypeptide binding]; other site 264730015144 catalytic site [active] 264730015145 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 264730015146 L-serine binding site [chemical binding]; other site 264730015147 ACT domain interface; other site 264730015148 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 264730015149 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 264730015150 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 264730015151 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 264730015152 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264730015153 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 264730015154 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 264730015155 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 264730015156 active site 264730015157 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264730015158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015159 dimer interface [polypeptide binding]; other site 264730015160 conserved gate region; other site 264730015161 putative PBP binding loops; other site 264730015162 ABC-ATPase subunit interface; other site 264730015163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015164 dimer interface [polypeptide binding]; other site 264730015165 conserved gate region; other site 264730015166 putative PBP binding loops; other site 264730015167 ABC-ATPase subunit interface; other site 264730015168 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 264730015169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730015170 Walker A/P-loop; other site 264730015171 ATP binding site [chemical binding]; other site 264730015172 Q-loop/lid; other site 264730015173 ABC transporter signature motif; other site 264730015174 Walker B; other site 264730015175 D-loop; other site 264730015176 H-loop/switch region; other site 264730015177 TOBE domain; Region: TOBE_2; pfam08402 264730015178 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 264730015179 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264730015180 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 264730015181 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264730015182 putative aminotransferase; Validated; Region: PRK07480 264730015183 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730015184 inhibitor-cofactor binding pocket; inhibition site 264730015185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730015186 catalytic residue [active] 264730015187 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 264730015188 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264730015189 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 264730015190 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264730015191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264730015192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264730015193 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730015194 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 264730015195 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 264730015196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730015197 Walker A/P-loop; other site 264730015198 ATP binding site [chemical binding]; other site 264730015199 Q-loop/lid; other site 264730015200 ABC transporter signature motif; other site 264730015201 Walker B; other site 264730015202 D-loop; other site 264730015203 H-loop/switch region; other site 264730015204 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264730015205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015206 dimer interface [polypeptide binding]; other site 264730015207 conserved gate region; other site 264730015208 putative PBP binding loops; other site 264730015209 ABC-ATPase subunit interface; other site 264730015210 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264730015211 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730015212 substrate binding pocket [chemical binding]; other site 264730015213 membrane-bound complex binding site; other site 264730015214 hinge residues; other site 264730015215 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264730015216 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 264730015217 dimer interface [polypeptide binding]; other site 264730015218 decamer (pentamer of dimers) interface [polypeptide binding]; other site 264730015219 catalytic triad [active] 264730015220 outer membrane porin, OprD family; Region: OprD; pfam03573 264730015221 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 264730015222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730015223 substrate binding pocket [chemical binding]; other site 264730015224 membrane-bound complex binding site; other site 264730015225 hinge residues; other site 264730015226 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 264730015227 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264730015228 Walker A/P-loop; other site 264730015229 ATP binding site [chemical binding]; other site 264730015230 Q-loop/lid; other site 264730015231 ABC transporter signature motif; other site 264730015232 Walker B; other site 264730015233 D-loop; other site 264730015234 H-loop/switch region; other site 264730015235 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264730015236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015237 dimer interface [polypeptide binding]; other site 264730015238 conserved gate region; other site 264730015239 putative PBP binding loops; other site 264730015240 ABC-ATPase subunit interface; other site 264730015241 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 264730015242 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 264730015243 SecA binding site; other site 264730015244 Preprotein binding site; other site 264730015245 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 264730015246 GSH binding site [chemical binding]; other site 264730015247 catalytic residues [active] 264730015248 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264730015249 active site residue [active] 264730015250 phosphoglyceromutase; Provisional; Region: PRK05434 264730015251 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 264730015252 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 264730015253 Peptidase family M23; Region: Peptidase_M23; pfam01551 264730015254 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264730015255 C-terminal peptidase (prc); Region: prc; TIGR00225 264730015256 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264730015257 protein binding site [polypeptide binding]; other site 264730015258 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264730015259 Catalytic dyad [active] 264730015260 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 264730015261 NodB motif; other site 264730015262 putative active site [active] 264730015263 putative catalytic site [active] 264730015264 Zn binding site [ion binding]; other site 264730015265 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 264730015266 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 264730015267 DNA-binding interface [nucleotide binding]; DNA binding site 264730015268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730015269 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730015270 substrate binding pocket [chemical binding]; other site 264730015271 membrane-bound complex binding site; other site 264730015272 hinge residues; other site 264730015273 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 264730015274 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 264730015275 substrate binding site [chemical binding]; other site 264730015276 glutamase interaction surface [polypeptide binding]; other site 264730015277 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 264730015278 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 264730015279 catalytic residues [active] 264730015280 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 264730015281 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 264730015282 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 264730015283 putative active site [active] 264730015284 oxyanion strand; other site 264730015285 catalytic triad [active] 264730015286 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 264730015287 putative active site pocket [active] 264730015288 4-fold oligomerization interface [polypeptide binding]; other site 264730015289 metal binding residues [ion binding]; metal-binding site 264730015290 3-fold/trimer interface [polypeptide binding]; other site 264730015291 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 264730015292 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730015293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730015294 homodimer interface [polypeptide binding]; other site 264730015295 catalytic residue [active] 264730015296 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 264730015297 AsmA family; Region: AsmA; pfam05170 264730015298 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 264730015299 adenine DNA glycosylase; Provisional; Region: PRK10880 264730015300 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264730015301 minor groove reading motif; other site 264730015302 helix-hairpin-helix signature motif; other site 264730015303 substrate binding pocket [chemical binding]; other site 264730015304 active site 264730015305 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 264730015306 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 264730015307 DNA binding and oxoG recognition site [nucleotide binding] 264730015308 oxidative damage protection protein; Provisional; Region: PRK05408 264730015309 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730015310 MULE transposase domain; Region: MULE; pfam10551 264730015311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730015312 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264730015313 putative active site [active] 264730015314 heme pocket [chemical binding]; other site 264730015315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730015316 putative active site [active] 264730015317 heme pocket [chemical binding]; other site 264730015318 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730015319 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730015320 dimer interface [polypeptide binding]; other site 264730015321 putative CheW interface [polypeptide binding]; other site 264730015322 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 264730015323 Spore germination protein; Region: Spore_permease; cl17796 264730015324 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 264730015325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264730015326 Walker A/P-loop; other site 264730015327 ATP binding site [chemical binding]; other site 264730015328 Q-loop/lid; other site 264730015329 ABC transporter signature motif; other site 264730015330 Walker B; other site 264730015331 D-loop; other site 264730015332 H-loop/switch region; other site 264730015333 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264730015334 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264730015335 substrate binding pocket [chemical binding]; other site 264730015336 membrane-bound complex binding site; other site 264730015337 hinge residues; other site 264730015338 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264730015339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015340 dimer interface [polypeptide binding]; other site 264730015341 conserved gate region; other site 264730015342 putative PBP binding loops; other site 264730015343 ABC-ATPase subunit interface; other site 264730015344 Methyltransferase domain; Region: Methyltransf_32; pfam13679 264730015345 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264730015346 HSP70 interaction site [polypeptide binding]; other site 264730015347 lysogenic prophage region; PHAGE06 264730015348 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 264730015349 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 264730015350 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 264730015351 Baseplate J-like protein; Region: Baseplate_J; cl01294 264730015352 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 264730015353 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 264730015354 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 264730015355 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 264730015356 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 264730015357 catalytic residue [active] 264730015358 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 264730015359 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 264730015360 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 264730015361 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 264730015362 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 264730015363 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 264730015364 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 264730015365 terminase ATPase subunit; Provisional; Region: P; PHA02535 264730015366 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730015367 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264730015368 active site 264730015369 catalytic residues [active] 264730015370 DNA binding site [nucleotide binding] 264730015371 Int/Topo IB signature motif; other site 264730015372 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 264730015373 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 264730015374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730015375 Coenzyme A binding pocket [chemical binding]; other site 264730015376 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 264730015377 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 264730015378 putative active site [active] 264730015379 putative NTP binding site [chemical binding]; other site 264730015380 putative nucleic acid binding site [nucleotide binding]; other site 264730015381 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 264730015382 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 264730015383 putative active site [active] 264730015384 putative NTP binding site [chemical binding]; other site 264730015385 putative nucleic acid binding site [nucleotide binding]; other site 264730015386 Protein of unknown function (DUF796); Region: DUF796; pfam05638 264730015387 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 264730015388 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730015389 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264730015390 active site 264730015391 catalytic residues [active] 264730015392 DNA binding site [nucleotide binding] 264730015393 Int/Topo IB signature motif; other site 264730015394 Protein of unknown function (DUF796); Region: DUF796; pfam05638 264730015395 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 264730015396 Integrase core domain; Region: rve; pfam00665 264730015397 DDE domain; Region: DDE_Tnp_IS240; pfam13610 264730015398 Integrase core domain; Region: rve_3; pfam13683 264730015399 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730015400 Transposase domain (DUF772); Region: DUF772; pfam05598 264730015401 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 264730015402 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264730015403 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 264730015404 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 264730015405 active site 264730015406 type IV secretion system component VirD4; Provisional; Region: PRK13897 264730015407 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 264730015408 active site 264730015409 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 264730015410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 264730015411 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264730015412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730015413 putative substrate translocation pore; other site 264730015414 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 264730015415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730015416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730015417 dimerization interface [polypeptide binding]; other site 264730015418 Membrane fusogenic activity; Region: BMFP; pfam04380 264730015419 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 264730015420 Nitrogen regulatory protein P-II; Region: P-II; smart00938 264730015421 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 264730015422 Uncharacterized conserved protein [Function unknown]; Region: COG0432 264730015423 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 264730015424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730015425 motif II; other site 264730015426 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 264730015427 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 264730015428 active site 264730015429 Int/Topo IB signature motif; other site 264730015430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3159 264730015431 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 264730015432 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264730015433 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264730015434 diaminopimelate decarboxylase; Region: lysA; TIGR01048 264730015435 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 264730015436 active site 264730015437 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264730015438 substrate binding site [chemical binding]; other site 264730015439 catalytic residues [active] 264730015440 dimer interface [polypeptide binding]; other site 264730015441 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 264730015442 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 264730015443 putative iron binding site [ion binding]; other site 264730015444 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 264730015445 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 264730015446 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264730015447 adenylate cyclase; Provisional; Region: cyaA; PRK09450 264730015448 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 264730015449 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 264730015450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730015451 TIGR02647 family protein; Region: DNA 264730015452 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 264730015453 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264730015454 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 264730015455 RimK-like ATP-grasp domain; Region: RimK; pfam08443 264730015456 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 264730015457 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730015458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264730015459 RNA binding surface [nucleotide binding]; other site 264730015460 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 264730015461 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 264730015462 dimerization interface [polypeptide binding]; other site 264730015463 domain crossover interface; other site 264730015464 redox-dependent activation switch; other site 264730015465 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 264730015466 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 264730015467 active site 264730015468 substrate-binding site [chemical binding]; other site 264730015469 metal-binding site [ion binding] 264730015470 ATP binding site [chemical binding]; other site 264730015471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730015472 Coenzyme A binding pocket [chemical binding]; other site 264730015473 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 264730015474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730015475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264730015476 Coenzyme A binding pocket [chemical binding]; other site 264730015477 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 264730015478 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 264730015479 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264730015480 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 264730015481 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264730015482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015483 dimer interface [polypeptide binding]; other site 264730015484 conserved gate region; other site 264730015485 putative PBP binding loops; other site 264730015486 ABC-ATPase subunit interface; other site 264730015487 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 264730015488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015489 dimer interface [polypeptide binding]; other site 264730015490 conserved gate region; other site 264730015491 ABC-ATPase subunit interface; other site 264730015492 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 264730015493 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730015494 Walker A/P-loop; other site 264730015495 ATP binding site [chemical binding]; other site 264730015496 Q-loop/lid; other site 264730015497 ABC transporter signature motif; other site 264730015498 Walker B; other site 264730015499 D-loop; other site 264730015500 H-loop/switch region; other site 264730015501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730015502 Walker A/P-loop; other site 264730015503 ATP binding site [chemical binding]; other site 264730015504 Q-loop/lid; other site 264730015505 ABC transporter signature motif; other site 264730015506 Walker B; other site 264730015507 D-loop; other site 264730015508 H-loop/switch region; other site 264730015509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730015510 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 264730015511 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 264730015512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264730015513 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 264730015514 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264730015515 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264730015516 acetylornithine deacetylase; Provisional; Region: PRK07522 264730015517 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 264730015518 metal binding site [ion binding]; metal-binding site 264730015519 putative dimer interface [polypeptide binding]; other site 264730015520 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264730015521 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 264730015522 putative ligand binding site [chemical binding]; other site 264730015523 NAD binding site [chemical binding]; other site 264730015524 dimerization interface [polypeptide binding]; other site 264730015525 catalytic site [active] 264730015526 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 264730015527 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730015528 inhibitor-cofactor binding pocket; inhibition site 264730015529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730015530 catalytic residue [active] 264730015531 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 264730015532 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264730015533 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730015534 putative DNA binding site [nucleotide binding]; other site 264730015535 putative Zn2+ binding site [ion binding]; other site 264730015536 AsnC family; Region: AsnC_trans_reg; pfam01037 264730015537 Transposase IS200 like; Region: Y1_Tnp; pfam01797 264730015538 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730015539 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730015540 dimer interface [polypeptide binding]; other site 264730015541 putative CheW interface [polypeptide binding]; other site 264730015542 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 264730015543 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730015544 Walker A/P-loop; other site 264730015545 ATP binding site [chemical binding]; other site 264730015546 Q-loop/lid; other site 264730015547 ABC transporter signature motif; other site 264730015548 Walker B; other site 264730015549 D-loop; other site 264730015550 H-loop/switch region; other site 264730015551 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 264730015552 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264730015553 Walker A/P-loop; other site 264730015554 ATP binding site [chemical binding]; other site 264730015555 Q-loop/lid; other site 264730015556 ABC transporter signature motif; other site 264730015557 Walker B; other site 264730015558 D-loop; other site 264730015559 H-loop/switch region; other site 264730015560 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264730015561 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 264730015562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015563 dimer interface [polypeptide binding]; other site 264730015564 conserved gate region; other site 264730015565 putative PBP binding loops; other site 264730015566 ABC-ATPase subunit interface; other site 264730015567 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 264730015568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015569 dimer interface [polypeptide binding]; other site 264730015570 conserved gate region; other site 264730015571 putative PBP binding loops; other site 264730015572 ABC-ATPase subunit interface; other site 264730015573 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 264730015574 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 264730015575 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730015576 N-terminal plug; other site 264730015577 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264730015578 ligand-binding site [chemical binding]; other site 264730015579 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264730015580 TolR protein; Region: tolR; TIGR02801 264730015581 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264730015582 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264730015583 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264730015584 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264730015585 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 264730015586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264730015587 catalytic residue [active] 264730015588 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264730015589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264730015590 putative DNA binding site [nucleotide binding]; other site 264730015591 putative Zn2+ binding site [ion binding]; other site 264730015592 AsnC family; Region: AsnC_trans_reg; pfam01037 264730015593 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 264730015594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730015595 salt bridge; other site 264730015596 non-specific DNA binding site [nucleotide binding]; other site 264730015597 sequence-specific DNA binding site [nucleotide binding]; other site 264730015598 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 264730015599 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 264730015600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730015601 motif II; other site 264730015602 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 264730015603 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 264730015604 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730015605 MULE transposase domain; Region: MULE; pfam10551 264730015606 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 264730015607 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264730015608 HD domain; Region: HD_4; pfam13328 264730015609 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 264730015610 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 264730015611 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 264730015612 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 264730015613 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 264730015614 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 264730015615 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 264730015616 PAAR motif; Region: PAAR_motif; pfam05488 264730015617 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264730015618 RHS Repeat; Region: RHS_repeat; pfam05593 264730015619 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264730015620 RHS Repeat; Region: RHS_repeat; cl11982 264730015621 RHS Repeat; Region: RHS_repeat; cl11982 264730015622 RHS protein; Region: RHS; pfam03527 264730015623 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264730015624 RHS Repeat; Region: RHS_repeat; pfam05593 264730015625 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264730015626 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264730015627 acyl carrier protein; Provisional; Region: acpP; PRK00982 264730015628 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264730015629 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264730015630 FIST N domain; Region: FIST; smart00897 264730015631 FIST C domain; Region: FIST_C; pfam10442 264730015632 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730015633 dimer interface [polypeptide binding]; other site 264730015634 putative CheW interface [polypeptide binding]; other site 264730015635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 264730015636 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 264730015637 hydrolase; Region: PLN02811 264730015638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264730015639 motif II; other site 264730015640 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264730015641 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264730015642 active site 264730015643 catalytic tetrad [active] 264730015644 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 264730015645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730015646 DNA-binding site [nucleotide binding]; DNA binding site 264730015647 FCD domain; Region: FCD; pfam07729 264730015648 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 264730015649 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 264730015650 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 264730015651 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 264730015652 acyl-activating enzyme (AAE) consensus motif; other site 264730015653 AMP binding site [chemical binding]; other site 264730015654 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 264730015655 thioester reductase domain; Region: Thioester-redct; TIGR01746 264730015656 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 264730015657 putative NAD(P) binding site [chemical binding]; other site 264730015658 active site 264730015659 putative substrate binding site [chemical binding]; other site 264730015660 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 264730015661 putative hydrophobic ligand binding site [chemical binding]; other site 264730015662 protein interface [polypeptide binding]; other site 264730015663 gate; other site 264730015664 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264730015665 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264730015666 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 264730015667 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264730015668 ligand binding site [chemical binding]; other site 264730015669 homodimer interface [polypeptide binding]; other site 264730015670 NAD(P) binding site [chemical binding]; other site 264730015671 trimer interface B [polypeptide binding]; other site 264730015672 trimer interface A [polypeptide binding]; other site 264730015673 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264730015674 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 264730015675 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264730015676 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 264730015677 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 264730015678 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 264730015679 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 264730015680 conserverd hypothetical protein; Region: TIGR02448 264730015681 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 264730015682 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 264730015683 Cell division protein FtsL; Region: FtsL; cl11433 264730015684 SCP-2 sterol transfer family; Region: SCP2; cl01225 264730015685 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264730015686 IHF dimer interface [polypeptide binding]; other site 264730015687 IHF - DNA interface [nucleotide binding]; other site 264730015688 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 264730015689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264730015690 Rubredoxin [Energy production and conversion]; Region: COG1773 264730015691 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 264730015692 iron binding site [ion binding]; other site 264730015693 Chorismate lyase; Region: Chor_lyase; cl01230 264730015694 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 264730015695 UbiA prenyltransferase family; Region: UbiA; pfam01040 264730015696 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 264730015697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730015698 active site 264730015699 phosphorylation site [posttranslational modification] 264730015700 intermolecular recognition site; other site 264730015701 dimerization interface [polypeptide binding]; other site 264730015702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264730015703 DNA binding site [nucleotide binding] 264730015704 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 264730015705 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264730015706 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264730015707 putative active site [active] 264730015708 heme pocket [chemical binding]; other site 264730015709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730015710 dimer interface [polypeptide binding]; other site 264730015711 phosphorylation site [posttranslational modification] 264730015712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730015713 ATP binding site [chemical binding]; other site 264730015714 Mg2+ binding site [ion binding]; other site 264730015715 G-X-G motif; other site 264730015716 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 264730015717 Domain of unknown function DUF21; Region: DUF21; pfam01595 264730015718 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264730015719 Transporter associated domain; Region: CorC_HlyC; smart01091 264730015720 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 264730015721 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264730015722 Peptidase family M23; Region: Peptidase_M23; pfam01551 264730015723 Response regulator receiver domain; Region: Response_reg; pfam00072 264730015724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730015725 active site 264730015726 phosphorylation site [posttranslational modification] 264730015727 intermolecular recognition site; other site 264730015728 dimerization interface [polypeptide binding]; other site 264730015729 transcriptional regulator PhoU; Provisional; Region: PRK11115 264730015730 PhoU domain; Region: PhoU; pfam01895 264730015731 PhoU domain; Region: PhoU; pfam01895 264730015732 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 264730015733 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 264730015734 Walker A/P-loop; other site 264730015735 ATP binding site [chemical binding]; other site 264730015736 Q-loop/lid; other site 264730015737 ABC transporter signature motif; other site 264730015738 Walker B; other site 264730015739 D-loop; other site 264730015740 H-loop/switch region; other site 264730015741 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 264730015742 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 264730015743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015744 dimer interface [polypeptide binding]; other site 264730015745 conserved gate region; other site 264730015746 putative PBP binding loops; other site 264730015747 ABC-ATPase subunit interface; other site 264730015748 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 264730015749 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 264730015750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015751 ABC-ATPase subunit interface; other site 264730015752 PBP superfamily domain; Region: PBP_like_2; cl17296 264730015753 metabolite-proton symporter; Region: 2A0106; TIGR00883 264730015754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730015755 putative substrate translocation pore; other site 264730015756 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 264730015757 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 264730015758 active site 264730015759 phosphate binding residues; other site 264730015760 catalytic residues [active] 264730015761 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 264730015762 Predicted membrane protein [Function unknown]; Region: COG2261 264730015763 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 264730015764 ATP-grasp domain; Region: ATP-grasp; pfam02222 264730015765 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 264730015766 cell density-dependent motility repressor; Provisional; Region: PRK10082 264730015767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730015768 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264730015769 dimerization interface [polypeptide binding]; other site 264730015770 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 264730015771 Aspartase; Region: Aspartase; cd01357 264730015772 active sites [active] 264730015773 tetramer interface [polypeptide binding]; other site 264730015774 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 264730015775 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 264730015776 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 264730015777 active site 264730015778 homodimer interface [polypeptide binding]; other site 264730015779 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 264730015780 Sulphur transport; Region: Sulf_transp; pfam04143 264730015781 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264730015782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730015783 DNA-binding site [nucleotide binding]; DNA binding site 264730015784 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264730015785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730015786 homodimer interface [polypeptide binding]; other site 264730015787 catalytic residue [active] 264730015788 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 264730015789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264730015790 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264730015791 Coenzyme A binding pocket [chemical binding]; other site 264730015792 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264730015793 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264730015794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264730015795 pyruvate carboxylase subunit B; Validated; Region: PRK09282 264730015796 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 264730015797 active site 264730015798 catalytic residues [active] 264730015799 metal binding site [ion binding]; metal-binding site 264730015800 homodimer binding site [polypeptide binding]; other site 264730015801 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264730015802 carboxyltransferase (CT) interaction site; other site 264730015803 biotinylation site [posttranslational modification]; other site 264730015804 pyruvate carboxylase subunit A; Validated; Region: PRK07178 264730015805 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264730015806 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 264730015807 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264730015808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730015809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730015810 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 264730015811 putative dimerization interface [polypeptide binding]; other site 264730015812 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 264730015813 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264730015814 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264730015815 putative active site [active] 264730015816 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 264730015817 Part of AAA domain; Region: AAA_19; pfam13245 264730015818 Family description; Region: UvrD_C_2; pfam13538 264730015819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 264730015820 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 264730015821 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264730015822 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 264730015823 pyridoxamine kinase; Validated; Region: PRK05756 264730015824 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 264730015825 pyridoxal binding site [chemical binding]; other site 264730015826 dimer interface [polypeptide binding]; other site 264730015827 ATP binding site [chemical binding]; other site 264730015828 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 264730015829 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264730015830 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 264730015831 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 264730015832 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 264730015833 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264730015834 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 264730015835 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 264730015836 AMIN domain; Region: AMIN; pfam11741 264730015837 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 264730015838 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264730015839 active site 264730015840 metal binding site [ion binding]; metal-binding site 264730015841 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 264730015842 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 264730015843 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 264730015844 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 264730015845 putative active site [active] 264730015846 catalytic site [active] 264730015847 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264730015848 putative active site [active] 264730015849 catalytic site [active] 264730015850 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 264730015851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730015852 S-adenosylmethionine binding site [chemical binding]; other site 264730015853 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 264730015854 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264730015855 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 264730015856 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 264730015857 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 264730015858 HflC protein; Region: hflC; TIGR01932 264730015859 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 264730015860 HflK protein; Region: hflK; TIGR01933 264730015861 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 264730015862 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 264730015863 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 264730015864 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 264730015865 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 264730015866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264730015867 active site 264730015868 phosphorylation site [posttranslational modification] 264730015869 intermolecular recognition site; other site 264730015870 dimerization interface [polypeptide binding]; other site 264730015871 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264730015872 dimerization interface [polypeptide binding]; other site 264730015873 DNA binding residues [nucleotide binding] 264730015874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264730015875 dimer interface [polypeptide binding]; other site 264730015876 phosphorylation site [posttranslational modification] 264730015877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264730015878 ATP binding site [chemical binding]; other site 264730015879 Mg2+ binding site [ion binding]; other site 264730015880 G-X-G motif; other site 264730015881 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264730015882 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264730015883 Walker A/P-loop; other site 264730015884 ATP binding site [chemical binding]; other site 264730015885 Q-loop/lid; other site 264730015886 ABC transporter signature motif; other site 264730015887 Walker B; other site 264730015888 D-loop; other site 264730015889 H-loop/switch region; other site 264730015890 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 264730015891 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 264730015892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015893 dimer interface [polypeptide binding]; other site 264730015894 conserved gate region; other site 264730015895 putative PBP binding loops; other site 264730015896 ABC-ATPase subunit interface; other site 264730015897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015898 dimer interface [polypeptide binding]; other site 264730015899 conserved gate region; other site 264730015900 putative PBP binding loops; other site 264730015901 ABC-ATPase subunit interface; other site 264730015902 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264730015903 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730015904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730015905 dimerization interface [polypeptide binding]; other site 264730015906 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730015907 dimer interface [polypeptide binding]; other site 264730015908 putative CheW interface [polypeptide binding]; other site 264730015909 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730015910 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730015911 dimerization interface [polypeptide binding]; other site 264730015912 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730015913 dimer interface [polypeptide binding]; other site 264730015914 putative CheW interface [polypeptide binding]; other site 264730015915 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 264730015916 dimanganese center [ion binding]; other site 264730015917 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 264730015918 ligand-binding site [chemical binding]; other site 264730015919 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 264730015920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264730015921 S-adenosylmethionine binding site [chemical binding]; other site 264730015922 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264730015923 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 264730015924 putative metal binding site [ion binding]; other site 264730015925 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264730015926 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264730015927 N-terminal plug; other site 264730015928 ligand-binding site [chemical binding]; other site 264730015929 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 264730015930 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264730015931 Walker A/P-loop; other site 264730015932 ATP binding site [chemical binding]; other site 264730015933 Q-loop/lid; other site 264730015934 ABC transporter signature motif; other site 264730015935 Walker B; other site 264730015936 D-loop; other site 264730015937 H-loop/switch region; other site 264730015938 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 264730015939 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 264730015940 putative ligand binding residues [chemical binding]; other site 264730015941 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 264730015942 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264730015943 ABC-ATPase subunit interface; other site 264730015944 dimer interface [polypeptide binding]; other site 264730015945 putative PBP binding regions; other site 264730015946 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 264730015947 trimer interface; other site 264730015948 sugar binding site [chemical binding]; other site 264730015949 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 264730015950 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 264730015951 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264730015952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015953 dimer interface [polypeptide binding]; other site 264730015954 conserved gate region; other site 264730015955 putative PBP binding loops; other site 264730015956 ABC-ATPase subunit interface; other site 264730015957 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264730015958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264730015959 dimer interface [polypeptide binding]; other site 264730015960 conserved gate region; other site 264730015961 putative PBP binding loops; other site 264730015962 ABC-ATPase subunit interface; other site 264730015963 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 264730015964 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 264730015965 Walker A/P-loop; other site 264730015966 ATP binding site [chemical binding]; other site 264730015967 Q-loop/lid; other site 264730015968 ABC transporter signature motif; other site 264730015969 Walker B; other site 264730015970 D-loop; other site 264730015971 H-loop/switch region; other site 264730015972 TOBE domain; Region: TOBE_2; pfam08402 264730015973 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 264730015974 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 264730015975 substrate binding [chemical binding]; other site 264730015976 active site 264730015977 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 264730015978 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264730015979 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264730015980 DNA binding site [nucleotide binding] 264730015981 domain linker motif; other site 264730015982 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 264730015983 putative dimerization interface [polypeptide binding]; other site 264730015984 putative ligand binding site [chemical binding]; other site 264730015985 Predicted transcriptional regulators [Transcription]; Region: COG1733 264730015986 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 264730015987 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 264730015988 EamA-like transporter family; Region: EamA; pfam00892 264730015989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264730015990 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730015991 MULE transposase domain; Region: MULE; pfam10551 264730015992 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 264730015993 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 264730015994 glutaminase active site [active] 264730015995 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 264730015996 dimer interface [polypeptide binding]; other site 264730015997 active site 264730015998 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 264730015999 dimer interface [polypeptide binding]; other site 264730016000 active site 264730016001 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 264730016002 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 264730016003 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264730016004 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 264730016005 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 264730016006 Substrate binding site; other site 264730016007 Mg++ binding site; other site 264730016008 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 264730016009 active site 264730016010 substrate binding site [chemical binding]; other site 264730016011 CoA binding site [chemical binding]; other site 264730016012 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 264730016013 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 264730016014 gamma subunit interface [polypeptide binding]; other site 264730016015 epsilon subunit interface [polypeptide binding]; other site 264730016016 LBP interface [polypeptide binding]; other site 264730016017 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 264730016018 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264730016019 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 264730016020 alpha subunit interaction interface [polypeptide binding]; other site 264730016021 Walker A motif; other site 264730016022 ATP binding site [chemical binding]; other site 264730016023 Walker B motif; other site 264730016024 inhibitor binding site; inhibition site 264730016025 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264730016026 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 264730016027 core domain interface [polypeptide binding]; other site 264730016028 delta subunit interface [polypeptide binding]; other site 264730016029 epsilon subunit interface [polypeptide binding]; other site 264730016030 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 264730016031 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264730016032 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 264730016033 beta subunit interaction interface [polypeptide binding]; other site 264730016034 Walker A motif; other site 264730016035 ATP binding site [chemical binding]; other site 264730016036 Walker B motif; other site 264730016037 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264730016038 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 264730016039 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 264730016040 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 264730016041 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 264730016042 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 264730016043 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 264730016044 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 264730016045 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 264730016046 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 264730016047 ParB-like nuclease domain; Region: ParBc; pfam02195 264730016048 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264730016049 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 264730016050 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264730016051 Magnesium ion binding site [ion binding]; other site 264730016052 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 264730016053 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 264730016054 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 264730016055 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 264730016056 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 264730016057 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 264730016058 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 264730016059 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 264730016060 trmE is a tRNA modification GTPase; Region: trmE; cd04164 264730016061 G1 box; other site 264730016062 GTP/Mg2+ binding site [chemical binding]; other site 264730016063 Switch I region; other site 264730016064 G2 box; other site 264730016065 Switch II region; other site 264730016066 G3 box; other site 264730016067 G4 box; other site 264730016068 G5 box; other site 264730016069 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 264730016070 membrane protein insertase; Provisional; Region: PRK01318 264730016071 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 264730016072 hypothetical protein; Provisional; Region: PRK14371 264730016073 ribonuclease P; Reviewed; Region: rnpA; PRK00396 264730016074 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 264730016075 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 264730016076 Putative transposase; Region: Y2_Tnp; pfam04986 264730016077 Replicase family; Region: Replicase; pfam03090 264730016078 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 264730016079 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 264730016080 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 264730016081 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 264730016082 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 264730016083 active site 264730016084 MULE transposase domain; Region: MULE; pfam10551 264730016085 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264730016086 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264730016087 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 264730016088 catalytic nucleophile [active] 264730016089 Helix-turn-helix domain; Region: HTH_37; pfam13744 264730016090 non-specific DNA binding site [nucleotide binding]; other site 264730016091 salt bridge; other site 264730016092 sequence-specific DNA binding site [nucleotide binding]; other site 264730016093 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 264730016094 active site 264730016095 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 264730016096 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730016097 metal binding site [ion binding]; metal-binding site 264730016098 active site 264730016099 I-site; other site 264730016100 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730016101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 264730016102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 264730016103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264730016104 Transposase; Region: HTH_Tnp_1; pfam01527 264730016105 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 264730016106 putative active site [active] 264730016107 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 264730016108 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264730016109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264730016110 dimerization interface [polypeptide binding]; other site 264730016111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730016112 dimer interface [polypeptide binding]; other site 264730016113 putative CheW interface [polypeptide binding]; other site 264730016114 HNH endonuclease; Region: HNH_5; pfam14279 264730016115 ParA-like protein; Provisional; Region: PHA02518 264730016116 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264730016117 P-loop; other site 264730016118 Magnesium ion binding site [ion binding]; other site 264730016119 ParG; Region: ParG; pfam09274 264730016120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264730016121 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569 264730016122 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 264730016123 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 264730016124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264730016125 Transposase; Region: HTH_Tnp_1; pfam01527 264730016126 putative transposase OrfB; Reviewed; Region: PHA02517 264730016127 HTH-like domain; Region: HTH_21; pfam13276 264730016128 Integrase core domain; Region: rve; pfam00665 264730016129 Integrase core domain; Region: rve_2; pfam13333 264730016130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264730016131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264730016132 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264730016133 dimerization interface [polypeptide binding]; other site 264730016134 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 264730016135 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 264730016136 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 264730016137 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 264730016138 PapC N-terminal domain; Region: PapC_N; pfam13954 264730016139 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 264730016140 putative pilin structural protein SafD; Provisional; Region: PRK15222 264730016141 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730016142 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730016143 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730016144 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264730016145 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 264730016146 catalytic residues [active] 264730016147 catalytic nucleophile [active] 264730016148 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 264730016149 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 264730016150 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 264730016151 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264730016152 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 264730016153 catalytic residues [active] 264730016154 catalytic nucleophile [active] 264730016155 PemK-like protein; Region: PemK; cl00995 264730016156 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 264730016157 dimerization interface [polypeptide binding]; other site 264730016158 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264730016159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264730016160 dimer interface [polypeptide binding]; other site 264730016161 putative CheW interface [polypeptide binding]; other site 264730016162 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730016163 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730016164 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730016165 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 264730016166 Putative transposase; Region: Y2_Tnp; pfam04986 264730016167 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264730016168 putative transposase OrfB; Reviewed; Region: PHA02517 264730016169 HTH-like domain; Region: HTH_21; pfam13276 264730016170 Integrase core domain; Region: rve; pfam00665 264730016171 Integrase core domain; Region: rve_3; pfam13683 264730016172 Transposase; Region: HTH_Tnp_1; cl17663 264730016173 SIR2-like domain; Region: SIR2_2; pfam13289 264730016174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264730016175 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 264730016176 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730016177 active site 264730016178 DNA binding site [nucleotide binding] 264730016179 Int/Topo IB signature motif; other site 264730016180 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 264730016181 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 264730016182 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264730016183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 264730016184 Transposase; Region: DEDD_Tnp_IS110; pfam01548 264730016185 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 264730016186 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 264730016187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264730016188 metal binding site [ion binding]; metal-binding site 264730016189 active site 264730016190 I-site; other site 264730016191 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264730016192 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264730016193 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264730016194 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264730016195 multiple promoter invertase; Provisional; Region: mpi; PRK13413 264730016196 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 264730016197 catalytic residues [active] 264730016198 catalytic nucleophile [active] 264730016199 Presynaptic Site I dimer interface [polypeptide binding]; other site 264730016200 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 264730016201 Synaptic Flat tetramer interface [polypeptide binding]; other site 264730016202 Synaptic Site I dimer interface [polypeptide binding]; other site 264730016203 DNA binding site [nucleotide binding] 264730016204 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 264730016205 DNA-binding interface [nucleotide binding]; DNA binding site 264730016206 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 264730016207 Global regulator protein family; Region: CsrA; pfam02599 264730016208 AAA domain; Region: AAA_17; pfam13207 264730016209 AAA domain; Region: AAA_18; pfam13238 264730016210 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 264730016211 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264730016212 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 264730016213 inhibitor-cofactor binding pocket; inhibition site 264730016214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264730016215 catalytic residue [active] 264730016216 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 264730016217 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 264730016218 active site 264730016219 iron coordination sites [ion binding]; other site 264730016220 substrate binding pocket [chemical binding]; other site 264730016221 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264730016222 catalytic core [active] 264730016223 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 264730016224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264730016225 Transposase; Region: HTH_Tnp_1; pfam01527 264730016226 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730016227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 264730016228 Transposase; Region: DEDD_Tnp_IS110; pfam01548 264730016229 MULE transposase domain; Region: MULE; pfam10551 264730016230 Transposase domain (DUF772); Region: DUF772; pfam05598 264730016231 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 264730016232 Avirulence protein; Region: AvrB_AvrC; pfam05394 264730016233 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 264730016234 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264730016235 Pto-interacting domain of the HopAB family of Type III Effector proteins; Region: HopAB_PID; cd12802 264730016236 Pto binding site [polypeptide binding]; other site 264730016237 BAK1-interacting domain of the HopAB family of Type III Effector proteins; Region: HopAB_BID; cd12803 264730016238 BAK1 binding site [polypeptide binding]; other site 264730016239 AvrPtoB E3 ubiquitin ligase; Region: AvrPtoB-E3_ubiq; pfam09046 264730016240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 264730016241 Transposase; Region: DEDD_Tnp_IS110; pfam01548 264730016242 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 264730016243 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543 264730016244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 264730016245 Transposase; Region: DEDD_Tnp_IS110; pfam01548 264730016246 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 264730016247 hypothetical protein; Validated; Region: PRK09169 264730016248 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264730016249 synthetase active site [active] 264730016250 NTP binding site [chemical binding]; other site 264730016251 metal binding site [ion binding]; metal-binding site 264730016252 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264730016253 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 264730016254 catalytic residues [active] 264730016255 catalytic nucleophile [active] 264730016256 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 264730016257 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 264730016258 oligomeric interface; other site 264730016259 putative active site [active] 264730016260 homodimer interface [polypeptide binding]; other site 264730016261 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 264730016262 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264730016263 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264730016264 P-loop; other site 264730016265 Magnesium ion binding site [ion binding]; other site 264730016266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 264730016267 Transposase; Region: DEDD_Tnp_IS110; pfam01548 264730016268 putative transposase OrfB; Reviewed; Region: PHA02517 264730016269 HTH-like domain; Region: HTH_21; pfam13276 264730016270 Integrase core domain; Region: rve; pfam00665 264730016271 Integrase core domain; Region: rve_3; pfam13683 264730016272 PemK-like protein; Region: PemK; pfam02452 264730016273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264730016274 Transposase; Region: HTH_Tnp_1; pfam01527 264730016275 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 264730016276 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 264730016277 VirB8 protein; Region: VirB8; pfam04335 264730016278 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 264730016279 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264730016280 Magnesium ion binding site [ion binding]; other site 264730016281 Replicase family; Region: Replicase; pfam03090 264730016282 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 264730016283 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264730016284 Catalytic site [active] 264730016285 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 264730016286 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 264730016287 active site 264730016288 DNA binding site [nucleotide binding] 264730016289 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 264730016290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730016291 non-specific DNA binding site [nucleotide binding]; other site 264730016292 sequence-specific DNA binding site [nucleotide binding]; other site 264730016293 salt bridge; other site 264730016294 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 264730016295 ParA-like protein; Provisional; Region: PHA02518 264730016296 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264730016297 P-loop; other site 264730016298 Magnesium ion binding site [ion binding]; other site 264730016299 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 264730016300 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264730016301 MULE transposase domain; Region: MULE; pfam10551 264730016302 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 264730016303 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 264730016304 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264730016305 active site 264730016306 DNA binding site [nucleotide binding] 264730016307 Int/Topo IB signature motif; other site 264730016308 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264730016309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730016310 DNA-binding site [nucleotide binding]; DNA binding site 264730016311 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264730016312 Predicted dehydrogenase [General function prediction only]; Region: COG0579 264730016313 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264730016314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730016315 metabolite-proton symporter; Region: 2A0106; TIGR00883 264730016316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264730016317 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264730016318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264730016319 non-specific DNA binding site [nucleotide binding]; other site 264730016320 salt bridge; other site 264730016321 sequence-specific DNA binding site [nucleotide binding]; other site 264730016322 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), AnFA1; Region: NGN_SP_AnfA1; cd09894 264730016323 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264730016324 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264730016325 catalytic residue [active] 264730016326 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 264730016327 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 264730016328 Type IV secretion system proteins; Region: T4SS; pfam07996 264730016329 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 264730016330 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 264730016331 VirB8 protein; Region: VirB8; pfam04335 264730016332 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 264730016333 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 264730016334 VirB7 interaction site; other site 264730016335 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 264730016336 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 264730016337 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264730016338 Walker A motif; other site 264730016339 ATP binding site [chemical binding]; other site 264730016340 Walker B motif; other site 264730016341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264730016342 ATP binding site [chemical binding]; other site 264730016343 Mg2+ binding site [ion binding]; other site 264730016344 G-X-G motif; other site 264730016345 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 264730016346 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264730016347 Walker A motif; other site 264730016348 ATP binding site [chemical binding]; other site 264730016349 Walker B motif; other site 264730016350 TrbM; Region: TrbM; pfam07424 264730016351 DNA topoisomerase III; Provisional; Region: PRK07726 264730016352 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 264730016353 active site 264730016354 putative interdomain interaction site [polypeptide binding]; other site 264730016355 putative metal-binding site [ion binding]; other site 264730016356 putative nucleotide binding site [chemical binding]; other site 264730016357 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 264730016358 domain I; other site 264730016359 DNA binding groove [nucleotide binding] 264730016360 phosphate binding site [ion binding]; other site 264730016361 domain II; other site 264730016362 domain III; other site 264730016363 nucleotide binding site [chemical binding]; other site 264730016364 catalytic site [active] 264730016365 domain IV; other site 264730016366 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 264730016367 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 264730016368 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264730016369 dimer interface [polypeptide binding]; other site 264730016370 ssDNA binding site [nucleotide binding]; other site 264730016371 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264730016372 conjugal transfer protein TraL; Provisional; Region: PRK13886 264730016373 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 264730016374 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 264730016375 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264730016376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264730016377 DNA-binding site [nucleotide binding]; DNA binding site 264730016378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 264730016379 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 264730016380 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264730016381 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 264730016382 catalytic residues [active] 264730016383 catalytic nucleophile [active] 264730016384 Presynaptic Site I dimer interface [polypeptide binding]; other site 264730016385 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 264730016386 Synaptic Flat tetramer interface [polypeptide binding]; other site 264730016387 Synaptic Site I dimer interface [polypeptide binding]; other site 264730016388 DNA binding site [nucleotide binding] 264730016389 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 264730016390 DNA-binding interface [nucleotide binding]; DNA binding site 264730016391 Winged helix-turn helix; Region: HTH_29; pfam13551 264730016392 Integrase core domain; Region: rve; pfam00665 264730016393 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 264730016394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264730016395 Walker A motif; other site 264730016396 ATP binding site [chemical binding]; other site 264730016397 Walker B motif; other site