-- dump date   	20140620_020232
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
223283000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
223283000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283000003	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
223283000004	Walker A motif; other site
223283000005	ATP binding site [chemical binding]; other site
223283000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
223283000007	Walker B motif; other site
223283000008	arginine finger; other site
223283000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
223283000010	DnaA box-binding interface [nucleotide binding]; other site
223283000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
223283000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
223283000013	putative DNA binding surface [nucleotide binding]; other site
223283000014	dimer interface [polypeptide binding]; other site
223283000015	beta-clamp/clamp loader binding surface; other site
223283000016	beta-clamp/translesion DNA polymerase binding surface; other site
223283000017	recombination protein F; Reviewed; Region: recF; PRK00064
223283000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283000019	Walker A/P-loop; other site
223283000020	ATP binding site [chemical binding]; other site
223283000021	Q-loop/lid; other site
223283000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283000023	ABC transporter signature motif; other site
223283000024	Walker B; other site
223283000025	D-loop; other site
223283000026	H-loop/switch region; other site
223283000027	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
223283000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283000029	ATP binding site [chemical binding]; other site
223283000030	Mg2+ binding site [ion binding]; other site
223283000031	G-X-G motif; other site
223283000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
223283000033	anchoring element; other site
223283000034	dimer interface [polypeptide binding]; other site
223283000035	ATP binding site [chemical binding]; other site
223283000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
223283000037	active site
223283000038	putative metal-binding site [ion binding]; other site
223283000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
223283000040	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
223283000041	HsdM N-terminal domain; Region: HsdM_N; pfam12161
223283000042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
223283000043	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
223283000044	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
223283000045	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
223283000046	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
223283000047	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
223283000048	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
223283000049	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
223283000050	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
223283000051	Putative transposase; Region: Y2_Tnp; pfam04986
223283000052	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
223283000053	Protein of unknown function DUF45; Region: DUF45; pfam01863
223283000054	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283000055	ATP binding site [chemical binding]; other site
223283000056	putative Mg++ binding site [ion binding]; other site
223283000057	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283000058	nucleotide binding region [chemical binding]; other site
223283000059	ATP-binding site [chemical binding]; other site
223283000060	transposase/IS protein; Provisional; Region: PRK09183
223283000061	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283000062	Walker A motif; other site
223283000063	ATP binding site [chemical binding]; other site
223283000064	Walker B motif; other site
223283000065	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283000066	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283000067	DNA-binding interface [nucleotide binding]; DNA binding site
223283000068	Integrase core domain; Region: rve; pfam00665
223283000069	Integrase core domain; Region: rve_3; cl15866
223283000070	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
223283000071	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283000072	motif II; other site
223283000073	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
223283000074	Integrase core domain; Region: rve; pfam00665
223283000075	Bacterial TniB protein; Region: TniB; pfam05621
223283000076	AAA domain; Region: AAA_22; pfam13401
223283000077	TniQ; Region: TniQ; pfam06527
223283000078	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
223283000079	putative active site [active]
223283000080	putative metal binding site [ion binding]; other site
223283000081	ParB-like nuclease domain; Region: ParBc; cl02129
223283000082	RepB plasmid partitioning protein; Region: RepB; pfam07506
223283000083	ParB-like nuclease domain; Region: ParB; smart00470
223283000084	RepB plasmid partitioning protein; Region: RepB; pfam07506
223283000085	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
223283000086	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
223283000087	catalytic residues [active]
223283000088	catalytic nucleophile [active]
223283000089	Recombinase; Region: Recombinase; pfam07508
223283000090	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283000091	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283000092	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283000093	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283000094	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283000095	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283000096	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283000097	Predicted helicase [General function prediction only]; Region: COG4889
223283000098	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
223283000099	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283000100	ATP binding site [chemical binding]; other site
223283000101	putative Mg++ binding site [ion binding]; other site
223283000102	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
223283000103	ATP-binding site [chemical binding]; other site
223283000104	Protein of unknown function DUF262; Region: DUF262; pfam03235
223283000105	Uncharacterized conserved protein [Function unknown]; Region: COG1479
223283000106	Uncharacterized conserved protein [Function unknown]; Region: COG1479
223283000107	Protein of unknown function DUF262; Region: DUF262; pfam03235
223283000108	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
223283000109	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283000110	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283000111	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283000112	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283000113	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283000114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283000115	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283000116	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
223283000117	active site
223283000118	Zn binding site [ion binding]; other site
223283000119	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
223283000120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283000121	Walker A/P-loop; other site
223283000122	ATP binding site [chemical binding]; other site
223283000123	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
223283000124	putative active site [active]
223283000125	putative metal-binding site [ion binding]; other site
223283000126	Part of AAA domain; Region: AAA_19; pfam13245
223283000127	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
223283000128	Family description; Region: UvrD_C_2; pfam13538
223283000129	Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505
223283000130	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
223283000131	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283000132	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283000133	DNA-binding interface [nucleotide binding]; DNA binding site
223283000134	Integrase core domain; Region: rve; pfam00665
223283000135	Integrase core domain; Region: rve_3; cl15866
223283000136	transposase/IS protein; Provisional; Region: PRK09183
223283000137	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283000138	Walker A motif; other site
223283000139	ATP binding site [chemical binding]; other site
223283000140	Walker B motif; other site
223283000141	Bacterial TniB protein; Region: TniB; pfam05621
223283000142	AAA domain; Region: AAA_22; pfam13401
223283000143	Helix-turn-helix domain; Region: HTH_28; pfam13518
223283000144	Winged helix-turn helix; Region: HTH_29; pfam13551
223283000145	Integrase core domain; Region: rve; pfam00665
223283000146	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
223283000147	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
223283000148	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
223283000149	HrpA pilus formation protein; Region: HrpA_pilin; pfam09589
223283000150	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
223283000151	Citrate transporter; Region: CitMHS; pfam03600
223283000152	Uncharacterized conserved protein [Function unknown]; Region: COG3791
223283000153	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
223283000154	putative deacylase active site [active]
223283000155	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
223283000156	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
223283000157	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
223283000158	generic binding surface II; other site
223283000159	ssDNA binding site; other site
223283000160	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283000161	ATP binding site [chemical binding]; other site
223283000162	putative Mg++ binding site [ion binding]; other site
223283000163	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283000164	nucleotide binding region [chemical binding]; other site
223283000165	ATP-binding site [chemical binding]; other site
223283000166	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
223283000167	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283000168	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
223283000169	dimerization interface [polypeptide binding]; other site
223283000170	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
223283000171	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
223283000172	biopolymer transport protein ExbD; Provisional; Region: PRK11267
223283000173	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
223283000174	tonB-system energizer ExbB; Region: exbB; TIGR02797
223283000175	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
223283000176	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
223283000177	putative NAD(P) binding site [chemical binding]; other site
223283000178	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
223283000179	homotrimer interaction site [polypeptide binding]; other site
223283000180	putative active site [active]
223283000181	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
223283000182	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
223283000183	Zn2+ binding site [ion binding]; other site
223283000184	Mg2+ binding site [ion binding]; other site
223283000185	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
223283000186	synthetase active site [active]
223283000187	NTP binding site [chemical binding]; other site
223283000188	metal binding site [ion binding]; metal-binding site
223283000189	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
223283000190	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
223283000191	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
223283000192	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
223283000193	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
223283000194	catalytic site [active]
223283000195	G-X2-G-X-G-K; other site
223283000196	hypothetical protein; Provisional; Region: PRK11820
223283000197	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
223283000198	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
223283000199	ribonuclease PH; Reviewed; Region: rph; PRK00173
223283000200	Ribonuclease PH; Region: RNase_PH_bact; cd11362
223283000201	hexamer interface [polypeptide binding]; other site
223283000202	active site
223283000203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
223283000204	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
223283000205	putative active site [active]
223283000206	putative catalytic site [active]
223283000207	putative DNA binding site [nucleotide binding]; other site
223283000208	putative phosphate binding site [ion binding]; other site
223283000209	metal binding site A [ion binding]; metal-binding site
223283000210	putative AP binding site [nucleotide binding]; other site
223283000211	putative metal binding site B [ion binding]; other site
223283000212	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
223283000213	active site
223283000214	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
223283000215	feedback inhibition sensing region; other site
223283000216	homohexameric interface [polypeptide binding]; other site
223283000217	nucleotide binding site [chemical binding]; other site
223283000218	N-acetyl-L-glutamate binding site [chemical binding]; other site
223283000219	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
223283000220	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
223283000221	active site
223283000222	substrate binding site [chemical binding]; other site
223283000223	metal binding site [ion binding]; metal-binding site
223283000224	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
223283000225	trimer interface [polypeptide binding]; other site
223283000226	active site
223283000227	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
223283000228	Flavoprotein; Region: Flavoprotein; pfam02441
223283000229	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
223283000230	hypothetical protein; Reviewed; Region: PRK00024
223283000231	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
223283000232	MPN+ (JAMM) motif; other site
223283000233	Zinc-binding site [ion binding]; other site
223283000234	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
223283000235	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
223283000236	peptide binding site [polypeptide binding]; other site
223283000237	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
223283000238	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
223283000239	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
223283000240	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
223283000241	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
223283000242	NAD(P) binding site [chemical binding]; other site
223283000243	catalytic residues [active]
223283000244	putative MFS family transporter protein; Provisional; Region: PRK03633
223283000245	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
223283000246	PLD-like domain; Region: PLDc_2; pfam13091
223283000247	putative active site [active]
223283000248	catalytic site [active]
223283000249	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
223283000250	PLD-like domain; Region: PLDc_2; pfam13091
223283000251	putative active site [active]
223283000252	catalytic site [active]
223283000253	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
223283000254	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283000255	DNA-binding site [nucleotide binding]; DNA binding site
223283000256	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283000257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283000258	homodimer interface [polypeptide binding]; other site
223283000259	catalytic residue [active]
223283000260	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
223283000261	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
223283000262	Flagellin N-methylase; Region: FliB; pfam03692
223283000263	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
223283000264	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283000265	putative DNA binding site [nucleotide binding]; other site
223283000266	putative Zn2+ binding site [ion binding]; other site
223283000267	AsnC family; Region: AsnC_trans_reg; pfam01037
223283000268	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
223283000269	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
223283000270	hydroxyglutarate oxidase; Provisional; Region: PRK11728
223283000271	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
223283000272	homotrimer interaction site [polypeptide binding]; other site
223283000273	putative active site [active]
223283000274	alanine racemase; Reviewed; Region: dadX; PRK03646
223283000275	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
223283000276	active site
223283000277	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
223283000278	substrate binding site [chemical binding]; other site
223283000279	catalytic residues [active]
223283000280	dimer interface [polypeptide binding]; other site
223283000281	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
223283000282	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283000283	non-specific DNA binding site [nucleotide binding]; other site
223283000284	salt bridge; other site
223283000285	sequence-specific DNA binding site [nucleotide binding]; other site
223283000286	Cupin domain; Region: Cupin_2; pfam07883
223283000287	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
223283000288	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
223283000289	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
223283000290	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
223283000291	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
223283000292	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
223283000293	PAS fold; Region: PAS_4; pfam08448
223283000294	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
223283000295	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283000296	Walker A motif; other site
223283000297	ATP binding site [chemical binding]; other site
223283000298	Walker B motif; other site
223283000299	arginine finger; other site
223283000300	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283000301	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
223283000302	active site
223283000303	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
223283000304	Part of AAA domain; Region: AAA_19; pfam13245
223283000305	Family description; Region: UvrD_C_2; pfam13538
223283000306	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283000307	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283000308	metal binding site [ion binding]; metal-binding site
223283000309	active site
223283000310	I-site; other site
223283000311	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283000312	multidrug efflux protein NorA; Provisional; Region: PRK00187
223283000313	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
223283000314	cation binding site [ion binding]; other site
223283000315	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
223283000316	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283000317	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283000318	dimerization interface [polypeptide binding]; other site
223283000319	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283000320	dimerization interface [polypeptide binding]; other site
223283000321	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283000322	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283000323	dimer interface [polypeptide binding]; other site
223283000324	putative CheW interface [polypeptide binding]; other site
223283000325	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
223283000326	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
223283000327	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
223283000328	PhoU domain; Region: PhoU; pfam01895
223283000329	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
223283000330	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
223283000331	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
223283000332	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
223283000333	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
223283000334	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
223283000335	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283000336	Transposase; Region: HTH_Tnp_1; cl17663
223283000337	putative transposase OrfB; Reviewed; Region: PHA02517
223283000338	HTH-like domain; Region: HTH_21; pfam13276
223283000339	Integrase core domain; Region: rve; pfam00665
223283000340	Integrase core domain; Region: rve_2; pfam13333
223283000341	argininosuccinate lyase; Provisional; Region: PRK00855
223283000342	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
223283000343	active sites [active]
223283000344	tetramer interface [polypeptide binding]; other site
223283000345	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
223283000346	Histidine kinase; Region: His_kinase; pfam06580
223283000347	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
223283000348	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283000349	active site
223283000350	phosphorylation site [posttranslational modification]
223283000351	intermolecular recognition site; other site
223283000352	dimerization interface [polypeptide binding]; other site
223283000353	LytTr DNA-binding domain; Region: LytTR; pfam04397
223283000354	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
223283000355	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
223283000356	domain interfaces; other site
223283000357	active site
223283000358	uroporphyrinogen-III synthase; Validated; Region: PRK05752
223283000359	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
223283000360	active site
223283000361	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
223283000362	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
223283000363	HemY protein N-terminus; Region: HemY_N; pfam07219
223283000364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283000365	binding surface
223283000366	TPR motif; other site
223283000367	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
223283000368	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
223283000369	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
223283000370	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
223283000371	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
223283000372	TIGR02444 family protein; Region: TIGR02444
223283000373	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
223283000374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283000375	Walker A/P-loop; other site
223283000376	ATP binding site [chemical binding]; other site
223283000377	Q-loop/lid; other site
223283000378	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
223283000379	ABC transporter signature motif; other site
223283000380	Walker B; other site
223283000381	D-loop; other site
223283000382	ABC transporter; Region: ABC_tran_2; pfam12848
223283000383	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
223283000384	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
223283000385	Mechanosensitive ion channel; Region: MS_channel; pfam00924
223283000386	LysE type translocator; Region: LysE; cl00565
223283000387	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
223283000388	Cytochrome c; Region: Cytochrom_C; pfam00034
223283000389	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
223283000390	conserved hypothetical metal-binding protein; Region: TIGR02443
223283000391	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
223283000392	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
223283000393	active site
223283000394	Zn binding site [ion binding]; other site
223283000395	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
223283000396	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
223283000397	trimer interface [polypeptide binding]; other site
223283000398	putative metal binding site [ion binding]; other site
223283000399	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
223283000400	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
223283000401	OPT oligopeptide transporter protein; Region: OPT; pfam03169
223283000402	Abi-like protein; Region: Abi_2; pfam07751
223283000403	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
223283000404	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
223283000405	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
223283000406	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
223283000407	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
223283000408	Dodecin; Region: Dodecin; pfam07311
223283000409	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
223283000410	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
223283000411	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283000412	The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482
223283000413	putative dimerization interface [polypeptide binding]; other site
223283000414	putative substrate binding pocket [chemical binding]; other site
223283000415	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
223283000416	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
223283000417	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283000418	catalytic residue [active]
223283000419	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
223283000420	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
223283000421	substrate binding site [chemical binding]; other site
223283000422	active site
223283000423	catalytic residues [active]
223283000424	heterodimer interface [polypeptide binding]; other site
223283000425	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
223283000426	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
223283000427	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
223283000428	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
223283000429	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283000430	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
223283000431	dimerization interface [polypeptide binding]; other site
223283000432	substrate binding pocket [chemical binding]; other site
223283000433	Sulfatase; Region: Sulfatase; cl17466
223283000434	choline-sulfatase; Region: chol_sulfatase; TIGR03417
223283000435	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
223283000436	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
223283000437	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
223283000438	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
223283000439	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
223283000440	Sulfate transporter family; Region: Sulfate_transp; pfam00916
223283000441	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
223283000442	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
223283000443	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
223283000444	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
223283000445	NAD(P) binding site [chemical binding]; other site
223283000446	shikimate binding site; other site
223283000447	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
223283000448	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
223283000449	Transposase domain (DUF772); Region: DUF772; pfam05598
223283000450	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283000451	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283000452	Protein of unknown function (DUF3630); Region: DUF3630; pfam12305
223283000453	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
223283000454	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
223283000455	NADP binding site [chemical binding]; other site
223283000456	dimer interface [polypeptide binding]; other site
223283000457	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
223283000458	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
223283000459	DNA protecting protein DprA; Region: dprA; TIGR00732
223283000460	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
223283000461	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
223283000462	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
223283000463	active site
223283000464	catalytic residues [active]
223283000465	metal binding site [ion binding]; metal-binding site
223283000466	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
223283000467	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
223283000468	putative active site [active]
223283000469	substrate binding site [chemical binding]; other site
223283000470	putative cosubstrate binding site; other site
223283000471	catalytic site [active]
223283000472	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
223283000473	substrate binding site [chemical binding]; other site
223283000474	16S rRNA methyltransferase B; Provisional; Region: PRK10901
223283000475	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
223283000476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283000477	S-adenosylmethionine binding site [chemical binding]; other site
223283000478	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
223283000479	TrkA-N domain; Region: TrkA_N; pfam02254
223283000480	TrkA-C domain; Region: TrkA_C; pfam02080
223283000481	TrkA-N domain; Region: TrkA_N; pfam02254
223283000482	TrkA-C domain; Region: TrkA_C; pfam02080
223283000483	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
223283000484	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
223283000485	putative molybdopterin cofactor binding site [chemical binding]; other site
223283000486	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
223283000487	putative molybdopterin cofactor binding site; other site
223283000488	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
223283000489	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
223283000490	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
223283000491	putative acyl-acceptor binding pocket; other site
223283000492	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
223283000493	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
223283000494	dimer interface [polypeptide binding]; other site
223283000495	motif 1; other site
223283000496	active site
223283000497	motif 2; other site
223283000498	motif 3; other site
223283000499	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
223283000500	HD domain; Region: HD; pfam01966
223283000501	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
223283000502	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283000503	active site
223283000504	motif I; other site
223283000505	motif II; other site
223283000506	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
223283000507	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
223283000508	putative acyl-acceptor binding pocket; other site
223283000509	Predicted amidohydrolase [General function prediction only]; Region: COG0388
223283000510	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
223283000511	putative active site [active]
223283000512	catalytic triad [active]
223283000513	putative dimer interface [polypeptide binding]; other site
223283000514	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
223283000515	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
223283000516	catalytic residues [active]
223283000517	catalytic nucleophile [active]
223283000518	Recombinase; Region: Recombinase; pfam07508
223283000519	transposase/IS protein; Provisional; Region: PRK09183
223283000520	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283000521	Walker A motif; other site
223283000522	ATP binding site [chemical binding]; other site
223283000523	Walker B motif; other site
223283000524	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283000525	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283000526	DNA-binding interface [nucleotide binding]; DNA binding site
223283000527	Integrase core domain; Region: rve; pfam00665
223283000528	Integrase core domain; Region: rve_3; cl15866
223283000529	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283000530	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283000531	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283000532	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283000533	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283000534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283000535	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283000536	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
223283000537	ATP-grasp domain; Region: ATP-grasp_4; cl17255
223283000538	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283000539	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283000540	putative substrate translocation pore; other site
223283000541	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
223283000542	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
223283000543	dimer interface [polypeptide binding]; other site
223283000544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283000545	catalytic residue [active]
223283000546	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
223283000547	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
223283000548	diaminopimelate decarboxylase; Provisional; Region: PRK11165
223283000549	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
223283000550	active site
223283000551	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
223283000552	substrate binding site [chemical binding]; other site
223283000553	catalytic residues [active]
223283000554	dimer interface [polypeptide binding]; other site
223283000555	EamA-like transporter family; Region: EamA; pfam00892
223283000556	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
223283000557	EamA-like transporter family; Region: EamA; pfam00892
223283000558	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
223283000559	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283000560	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283000561	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
223283000562	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283000563	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283000564	dimerization interface [polypeptide binding]; other site
223283000565	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
223283000566	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
223283000567	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283000568	non-specific DNA binding site [nucleotide binding]; other site
223283000569	salt bridge; other site
223283000570	sequence-specific DNA binding site [nucleotide binding]; other site
223283000571	Membrane fusogenic activity; Region: BMFP; pfam04380
223283000572	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
223283000573	Nitrogen regulatory protein P-II; Region: P-II; smart00938
223283000574	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
223283000575	Uncharacterized conserved protein [Function unknown]; Region: COG0432
223283000576	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
223283000577	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283000578	motif II; other site
223283000579	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
223283000580	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
223283000581	active site
223283000582	Int/Topo IB signature motif; other site
223283000583	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3159
223283000584	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
223283000585	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
223283000586	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
223283000587	diaminopimelate decarboxylase; Region: lysA; TIGR01048
223283000588	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
223283000589	active site
223283000590	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
223283000591	substrate binding site [chemical binding]; other site
223283000592	catalytic residues [active]
223283000593	dimer interface [polypeptide binding]; other site
223283000594	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
223283000595	frataxin-like protein; Provisional; Region: cyaY; PRK00446
223283000596	putative iron binding site [ion binding]; other site
223283000597	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
223283000598	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
223283000599	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
223283000600	adenylate cyclase; Provisional; Region: cyaA; PRK09450
223283000601	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
223283000602	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
223283000603	TIGR02647 family protein; Region: DNA
223283000604	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
223283000605	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
223283000606	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
223283000607	RimK-like ATP-grasp domain; Region: RimK; pfam08443
223283000608	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
223283000609	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283000610	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
223283000611	RNA binding surface [nucleotide binding]; other site
223283000612	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
223283000613	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
223283000614	dimerization interface [polypeptide binding]; other site
223283000615	domain crossover interface; other site
223283000616	redox-dependent activation switch; other site
223283000617	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
223283000618	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
223283000619	active site
223283000620	substrate-binding site [chemical binding]; other site
223283000621	metal-binding site [ion binding]
223283000622	ATP binding site [chemical binding]; other site
223283000623	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
223283000624	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
223283000625	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
223283000626	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
223283000627	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283000628	Coenzyme A binding pocket [chemical binding]; other site
223283000629	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
223283000630	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
223283000631	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
223283000632	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
223283000633	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
223283000634	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
223283000635	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
223283000636	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283000637	dimer interface [polypeptide binding]; other site
223283000638	conserved gate region; other site
223283000639	putative PBP binding loops; other site
223283000640	ABC-ATPase subunit interface; other site
223283000641	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
223283000642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283000643	dimer interface [polypeptide binding]; other site
223283000644	conserved gate region; other site
223283000645	ABC-ATPase subunit interface; other site
223283000646	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
223283000647	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283000648	Walker A/P-loop; other site
223283000649	ATP binding site [chemical binding]; other site
223283000650	Q-loop/lid; other site
223283000651	ABC transporter signature motif; other site
223283000652	Walker B; other site
223283000653	D-loop; other site
223283000654	H-loop/switch region; other site
223283000655	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283000656	Walker A/P-loop; other site
223283000657	ATP binding site [chemical binding]; other site
223283000658	Q-loop/lid; other site
223283000659	ABC transporter signature motif; other site
223283000660	Walker B; other site
223283000661	D-loop; other site
223283000662	H-loop/switch region; other site
223283000663	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
223283000664	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
223283000665	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
223283000666	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
223283000667	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
223283000668	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
223283000669	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
223283000670	acetylornithine deacetylase; Provisional; Region: PRK07522
223283000671	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
223283000672	metal binding site [ion binding]; metal-binding site
223283000673	putative dimer interface [polypeptide binding]; other site
223283000674	succinic semialdehyde dehydrogenase; Region: PLN02278
223283000675	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
223283000676	tetramerization interface [polypeptide binding]; other site
223283000677	NAD(P) binding site [chemical binding]; other site
223283000678	catalytic residues [active]
223283000679	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
223283000680	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
223283000681	putative ligand binding site [chemical binding]; other site
223283000682	NAD binding site [chemical binding]; other site
223283000683	dimerization interface [polypeptide binding]; other site
223283000684	catalytic site [active]
223283000685	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
223283000686	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283000687	inhibitor-cofactor binding pocket; inhibition site
223283000688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283000689	catalytic residue [active]
223283000690	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
223283000691	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
223283000692	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283000693	putative DNA binding site [nucleotide binding]; other site
223283000694	putative Zn2+ binding site [ion binding]; other site
223283000695	AsnC family; Region: AsnC_trans_reg; pfam01037
223283000696	Transposase IS200 like; Region: Y1_Tnp; pfam01797
223283000697	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283000698	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283000699	dimer interface [polypeptide binding]; other site
223283000700	putative CheW interface [polypeptide binding]; other site
223283000701	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
223283000702	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283000703	Walker A/P-loop; other site
223283000704	ATP binding site [chemical binding]; other site
223283000705	Q-loop/lid; other site
223283000706	ABC transporter signature motif; other site
223283000707	Walker B; other site
223283000708	D-loop; other site
223283000709	H-loop/switch region; other site
223283000710	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
223283000711	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283000712	Walker A/P-loop; other site
223283000713	ATP binding site [chemical binding]; other site
223283000714	Q-loop/lid; other site
223283000715	ABC transporter signature motif; other site
223283000716	Walker B; other site
223283000717	D-loop; other site
223283000718	H-loop/switch region; other site
223283000719	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283000720	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
223283000721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283000722	dimer interface [polypeptide binding]; other site
223283000723	conserved gate region; other site
223283000724	putative PBP binding loops; other site
223283000725	ABC-ATPase subunit interface; other site
223283000726	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
223283000727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283000728	dimer interface [polypeptide binding]; other site
223283000729	conserved gate region; other site
223283000730	putative PBP binding loops; other site
223283000731	ABC-ATPase subunit interface; other site
223283000732	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
223283000733	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
223283000734	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
223283000735	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283000736	N-terminal plug; other site
223283000737	ligand-binding site [chemical binding]; other site
223283000738	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
223283000739	TolR protein; Region: tolR; TIGR02801
223283000740	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
223283000741	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
223283000742	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
223283000743	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
223283000744	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
223283000745	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283000746	catalytic residue [active]
223283000747	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
223283000748	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283000749	putative DNA binding site [nucleotide binding]; other site
223283000750	putative Zn2+ binding site [ion binding]; other site
223283000751	AsnC family; Region: AsnC_trans_reg; pfam01037
223283000752	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283000753	salt bridge; other site
223283000754	non-specific DNA binding site [nucleotide binding]; other site
223283000755	sequence-specific DNA binding site [nucleotide binding]; other site
223283000756	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
223283000757	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
223283000758	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283000759	motif II; other site
223283000760	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
223283000761	Protein of unknown function (DUF805); Region: DUF805; pfam05656
223283000762	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
223283000763	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
223283000764	active site
223283000765	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283000766	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283000767	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
223283000768	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
223283000769	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
223283000770	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
223283000771	active site
223283000772	DNA binding site [nucleotide binding]
223283000773	Int/Topo IB signature motif; other site
223283000774	Helix-turn-helix domain; Region: HTH_17; cl17695
223283000775	Helix-turn-helix domain; Region: HTH_39; pfam14090
223283000776	transposase/IS protein; Provisional; Region: PRK09183
223283000777	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283000778	Walker A motif; other site
223283000779	ATP binding site [chemical binding]; other site
223283000780	Walker B motif; other site
223283000781	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283000782	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283000783	DNA-binding interface [nucleotide binding]; DNA binding site
223283000784	Integrase core domain; Region: rve; pfam00665
223283000785	Integrase core domain; Region: rve_3; cl15866
223283000786	multiple promoter invertase; Provisional; Region: mpi; PRK13413
223283000787	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
223283000788	catalytic residues [active]
223283000789	catalytic nucleophile [active]
223283000790	hypothetical protein; Provisional; Region: PRK07236
223283000791	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
223283000792	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
223283000793	tetramerization interface [polypeptide binding]; other site
223283000794	NAD(P) binding site [chemical binding]; other site
223283000795	catalytic residues [active]
223283000796	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
223283000797	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283000798	inhibitor-cofactor binding pocket; inhibition site
223283000799	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283000800	catalytic residue [active]
223283000801	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283000802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283000803	active site
223283000804	phosphorylation site [posttranslational modification]
223283000805	intermolecular recognition site; other site
223283000806	dimerization interface [polypeptide binding]; other site
223283000807	HDOD domain; Region: HDOD; pfam08668
223283000808	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283000809	PAS fold; Region: PAS_3; pfam08447
223283000810	putative active site [active]
223283000811	heme pocket [chemical binding]; other site
223283000812	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283000813	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283000814	metal binding site [ion binding]; metal-binding site
223283000815	active site
223283000816	I-site; other site
223283000817	Fatty acid desaturase; Region: FA_desaturase; pfam00487
223283000818	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
223283000819	Di-iron ligands [ion binding]; other site
223283000820	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
223283000821	Transposase; Region: DDE_Tnp_ISL3; pfam01610
223283000822	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283000823	PAS domain; Region: PAS_9; pfam13426
223283000824	putative active site [active]
223283000825	heme pocket [chemical binding]; other site
223283000826	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283000827	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283000828	metal binding site [ion binding]; metal-binding site
223283000829	active site
223283000830	I-site; other site
223283000831	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283000832	Uncharacterized small protein [Function unknown]; Region: COG5583
223283000833	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
223283000834	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
223283000835	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
223283000836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283000837	dimer interface [polypeptide binding]; other site
223283000838	conserved gate region; other site
223283000839	putative PBP binding loops; other site
223283000840	ABC-ATPase subunit interface; other site
223283000841	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
223283000842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283000843	dimer interface [polypeptide binding]; other site
223283000844	conserved gate region; other site
223283000845	putative PBP binding loops; other site
223283000846	ABC-ATPase subunit interface; other site
223283000847	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
223283000848	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
223283000849	Walker A/P-loop; other site
223283000850	ATP binding site [chemical binding]; other site
223283000851	Q-loop/lid; other site
223283000852	ABC transporter signature motif; other site
223283000853	Walker B; other site
223283000854	D-loop; other site
223283000855	H-loop/switch region; other site
223283000856	TOBE-like domain; Region: TOBE_3; pfam12857
223283000857	Predicted membrane protein [Function unknown]; Region: COG4539
223283000858	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
223283000859	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
223283000860	ligand binding site [chemical binding]; other site
223283000861	flexible hinge region; other site
223283000862	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
223283000863	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
223283000864	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
223283000865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283000866	dimer interface [polypeptide binding]; other site
223283000867	conserved gate region; other site
223283000868	putative PBP binding loops; other site
223283000869	ABC-ATPase subunit interface; other site
223283000870	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283000871	dimer interface [polypeptide binding]; other site
223283000872	conserved gate region; other site
223283000873	putative PBP binding loops; other site
223283000874	ABC-ATPase subunit interface; other site
223283000875	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
223283000876	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
223283000877	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
223283000878	lipoyl attachment site [posttranslational modification]; other site
223283000879	conserverd hypothetical protein; Region: TIGR02448
223283000880	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
223283000881	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
223283000882	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
223283000883	Walker A motif; other site
223283000884	ATP binding site [chemical binding]; other site
223283000885	Walker B motif; other site
223283000886	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
223283000887	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283000888	putative DNA binding site [nucleotide binding]; other site
223283000889	putative Zn2+ binding site [ion binding]; other site
223283000890	AsnC family; Region: AsnC_trans_reg; pfam01037
223283000891	Uncharacterized conserved protein [Function unknown]; Region: COG3025
223283000892	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
223283000893	putative active site [active]
223283000894	putative metal binding residues [ion binding]; other site
223283000895	signature motif; other site
223283000896	putative triphosphate binding site [ion binding]; other site
223283000897	acetylornithine deacetylase; Provisional; Region: PRK05111
223283000898	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
223283000899	metal binding site [ion binding]; metal-binding site
223283000900	putative dimer interface [polypeptide binding]; other site
223283000901	N-acetylglutamate synthase; Validated; Region: PRK05279
223283000902	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
223283000903	putative feedback inhibition sensing region; other site
223283000904	putative nucleotide binding site [chemical binding]; other site
223283000905	putative substrate binding site [chemical binding]; other site
223283000906	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283000907	Coenzyme A binding pocket [chemical binding]; other site
223283000908	glutamate--cysteine ligase; Provisional; Region: PRK02107
223283000909	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
223283000910	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
223283000911	CoenzymeA binding site [chemical binding]; other site
223283000912	subunit interaction site [polypeptide binding]; other site
223283000913	PHB binding site; other site
223283000914	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
223283000915	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
223283000916	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
223283000917	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
223283000918	RNA binding site [nucleotide binding]; other site
223283000919	osmolarity response regulator; Provisional; Region: ompR; PRK09468
223283000920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283000921	active site
223283000922	phosphorylation site [posttranslational modification]
223283000923	intermolecular recognition site; other site
223283000924	dimerization interface [polypeptide binding]; other site
223283000925	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283000926	DNA binding site [nucleotide binding]
223283000927	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
223283000928	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283000929	dimerization interface [polypeptide binding]; other site
223283000930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283000931	ATP binding site [chemical binding]; other site
223283000932	Mg2+ binding site [ion binding]; other site
223283000933	G-X-G motif; other site
223283000934	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816
223283000935	BON domain; Region: BON; pfam04972
223283000936	BON domain; Region: BON; pfam04972
223283000937	BON domain; Region: BON; pfam04972
223283000938	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
223283000939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283000940	active site
223283000941	phosphorylation site [posttranslational modification]
223283000942	intermolecular recognition site; other site
223283000943	dimerization interface [polypeptide binding]; other site
223283000944	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283000945	Walker A motif; other site
223283000946	ATP binding site [chemical binding]; other site
223283000947	Walker B motif; other site
223283000948	arginine finger; other site
223283000949	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283000950	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283000951	dimerization interface [polypeptide binding]; other site
223283000952	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
223283000953	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283000954	putative active site [active]
223283000955	heme pocket [chemical binding]; other site
223283000956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283000957	dimer interface [polypeptide binding]; other site
223283000958	phosphorylation site [posttranslational modification]
223283000959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283000960	ATP binding site [chemical binding]; other site
223283000961	Mg2+ binding site [ion binding]; other site
223283000962	G-X-G motif; other site
223283000963	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
223283000964	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
223283000965	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
223283000966	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
223283000967	amidase catalytic site [active]
223283000968	Zn binding residues [ion binding]; other site
223283000969	substrate binding site [chemical binding]; other site
223283000970	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
223283000971	Protein of unknown function (DUF3729); Region: DUF3729; pfam12526
223283000972	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283000973	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283000974	metal binding site [ion binding]; metal-binding site
223283000975	active site
223283000976	I-site; other site
223283000977	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
223283000978	putative catalytic site [active]
223283000979	putative metal binding site [ion binding]; other site
223283000980	putative phosphate binding site [ion binding]; other site
223283000981	putative catalytic site [active]
223283000982	putative phosphate binding site [ion binding]; other site
223283000983	putative metal binding site [ion binding]; other site
223283000984	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
223283000985	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
223283000986	catalytic residues [active]
223283000987	hinge region; other site
223283000988	alpha helical domain; other site
223283000989	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
223283000990	G1 box; other site
223283000991	GTP/Mg2+ binding site [chemical binding]; other site
223283000992	Switch I region; other site
223283000993	G2 box; other site
223283000994	G3 box; other site
223283000995	Switch II region; other site
223283000996	G4 box; other site
223283000997	G5 box; other site
223283000998	DNA polymerase I; Provisional; Region: PRK05755
223283000999	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
223283001000	active site
223283001001	metal binding site 1 [ion binding]; metal-binding site
223283001002	putative 5' ssDNA interaction site; other site
223283001003	metal binding site 3; metal-binding site
223283001004	metal binding site 2 [ion binding]; metal-binding site
223283001005	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
223283001006	putative DNA binding site [nucleotide binding]; other site
223283001007	putative metal binding site [ion binding]; other site
223283001008	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
223283001009	active site
223283001010	catalytic site [active]
223283001011	substrate binding site [chemical binding]; other site
223283001012	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
223283001013	active site
223283001014	DNA binding site [nucleotide binding]
223283001015	catalytic site [active]
223283001016	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
223283001017	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
223283001018	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
223283001019	putative active site [active]
223283001020	putative substrate binding site [chemical binding]; other site
223283001021	ATP binding site [chemical binding]; other site
223283001022	Transcriptional regulators [Transcription]; Region: PurR; COG1609
223283001023	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
223283001024	DNA binding site [nucleotide binding]
223283001025	domain linker motif; other site
223283001026	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
223283001027	putative dimerization interface [polypeptide binding]; other site
223283001028	putative ligand binding site [chemical binding]; other site
223283001029	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
223283001030	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
223283001031	active site
223283001032	non-prolyl cis peptide bond; other site
223283001033	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
223283001034	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283001035	substrate binding pocket [chemical binding]; other site
223283001036	membrane-bound complex binding site; other site
223283001037	hinge residues; other site
223283001038	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
223283001039	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
223283001040	active site
223283001041	catalytic tetrad [active]
223283001042	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
223283001043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283001044	active site
223283001045	phosphorylation site [posttranslational modification]
223283001046	intermolecular recognition site; other site
223283001047	dimerization interface [polypeptide binding]; other site
223283001048	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283001049	Walker A motif; other site
223283001050	ATP binding site [chemical binding]; other site
223283001051	Walker B motif; other site
223283001052	arginine finger; other site
223283001053	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283001054	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
223283001055	PAS domain; Region: PAS; smart00091
223283001056	putative active site [active]
223283001057	heme pocket [chemical binding]; other site
223283001058	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283001059	dimer interface [polypeptide binding]; other site
223283001060	phosphorylation site [posttranslational modification]
223283001061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283001062	ATP binding site [chemical binding]; other site
223283001063	Mg2+ binding site [ion binding]; other site
223283001064	G-X-G motif; other site
223283001065	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
223283001066	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
223283001067	chorismate mutase; Provisional; Region: PRK09269
223283001068	Chorismate mutase type II; Region: CM_2; cl00693
223283001069	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283001070	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283001071	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283001072	glutamine synthetase; Provisional; Region: glnA; PRK09469
223283001073	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
223283001074	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
223283001075	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
223283001076	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
223283001077	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
223283001078	Ligand Binding Site [chemical binding]; other site
223283001079	thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271
223283001080	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
223283001081	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
223283001082	G1 box; other site
223283001083	putative GEF interaction site [polypeptide binding]; other site
223283001084	GTP/Mg2+ binding site [chemical binding]; other site
223283001085	Switch I region; other site
223283001086	G2 box; other site
223283001087	G3 box; other site
223283001088	Switch II region; other site
223283001089	G4 box; other site
223283001090	G5 box; other site
223283001091	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
223283001092	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
223283001093	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
223283001094	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
223283001095	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
223283001096	sorbitol dehydrogenase; Provisional; Region: PRK07067
223283001097	Sorbitol dehydrogenase (SDH), classical (c) SDR; Region: SDH_SDR_c; cd05363
223283001098	putative NAD(P) binding site [chemical binding]; other site
223283001099	active site
223283001100	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
223283001101	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
223283001102	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
223283001103	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
223283001104	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283001105	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
223283001106	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
223283001107	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
223283001108	outer membrane porin, OprD family; Region: OprD; pfam03573
223283001109	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
223283001110	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
223283001111	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
223283001112	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
223283001113	acyl-activating enzyme (AAE) consensus motif; other site
223283001114	CoA binding site [chemical binding]; other site
223283001115	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
223283001116	Transposase; Region: DEDD_Tnp_IS110; pfam01548
223283001117	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
223283001118	PAAR motif; Region: PAAR_motif; pfam05488
223283001119	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
223283001120	RHS Repeat; Region: RHS_repeat; cl11982
223283001121	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
223283001122	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
223283001123	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283001124	Outer membrane efflux protein; Region: OEP; pfam02321
223283001125	Outer membrane efflux protein; Region: OEP; pfam02321
223283001126	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
223283001127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283001128	active site
223283001129	phosphorylation site [posttranslational modification]
223283001130	intermolecular recognition site; other site
223283001131	dimerization interface [polypeptide binding]; other site
223283001132	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283001133	DNA binding site [nucleotide binding]
223283001134	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
223283001135	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283001136	dimerization interface [polypeptide binding]; other site
223283001137	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283001138	dimer interface [polypeptide binding]; other site
223283001139	phosphorylation site [posttranslational modification]
223283001140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283001141	ATP binding site [chemical binding]; other site
223283001142	Mg2+ binding site [ion binding]; other site
223283001143	G-X-G motif; other site
223283001144	Predicted membrane protein [Function unknown]; Region: COG3686
223283001145	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
223283001146	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
223283001147	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
223283001148	nucleotide binding pocket [chemical binding]; other site
223283001149	K-X-D-G motif; other site
223283001150	catalytic site [active]
223283001151	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
223283001152	S-adenosylmethionine synthetase; Validated; Region: PRK05250
223283001153	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
223283001154	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
223283001155	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
223283001156	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283001157	putative DNA binding site [nucleotide binding]; other site
223283001158	putative Zn2+ binding site [ion binding]; other site
223283001159	Methyltransferase domain; Region: Methyltransf_31; pfam13847
223283001160	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283001161	S-adenosylmethionine binding site [chemical binding]; other site
223283001162	transketolase; Reviewed; Region: PRK12753
223283001163	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
223283001164	TPP-binding site [chemical binding]; other site
223283001165	dimer interface [polypeptide binding]; other site
223283001166	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
223283001167	PYR/PP interface [polypeptide binding]; other site
223283001168	dimer interface [polypeptide binding]; other site
223283001169	TPP binding site [chemical binding]; other site
223283001170	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
223283001171	erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532
223283001172	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
223283001173	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
223283001174	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
223283001175	Phosphoglycerate kinase; Region: PGK; pfam00162
223283001176	substrate binding site [chemical binding]; other site
223283001177	hinge regions; other site
223283001178	ADP binding site [chemical binding]; other site
223283001179	catalytic site [active]
223283001180	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
223283001181	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
223283001182	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
223283001183	intersubunit interface [polypeptide binding]; other site
223283001184	active site
223283001185	zinc binding site [ion binding]; other site
223283001186	Na+ binding site [ion binding]; other site
223283001187	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
223283001188	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
223283001189	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
223283001190	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
223283001191	active site
223283001192	V4R domain; Region: V4R; cl15268
223283001193	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
223283001194	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
223283001195	putative active site [active]
223283001196	putative FMN binding site [chemical binding]; other site
223283001197	putative substrate binding site [chemical binding]; other site
223283001198	putative catalytic residue [active]
223283001199	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
223283001200	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
223283001201	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
223283001202	Cysteine-rich domain; Region: CCG; pfam02754
223283001203	Cysteine-rich domain; Region: CCG; pfam02754
223283001204	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
223283001205	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
223283001206	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
223283001207	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
223283001208	Ligand Binding Site [chemical binding]; other site
223283001209	Electron transfer flavoprotein domain; Region: ETF; pfam01012
223283001210	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
223283001211	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
223283001212	putative active site [active]
223283001213	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
223283001214	Interdomain contacts; other site
223283001215	Cytokine receptor motif; other site
223283001216	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
223283001217	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
223283001218	Interdomain contacts; other site
223283001219	Cytokine receptor motif; other site
223283001220	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
223283001221	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
223283001222	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
223283001223	[2Fe-2S] cluster binding site [ion binding]; other site
223283001224	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
223283001225	putative alpha subunit interface [polypeptide binding]; other site
223283001226	putative active site [active]
223283001227	putative substrate binding site [chemical binding]; other site
223283001228	Fe binding site [ion binding]; other site
223283001229	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
223283001230	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
223283001231	FAD binding pocket [chemical binding]; other site
223283001232	FAD binding motif [chemical binding]; other site
223283001233	phosphate binding motif [ion binding]; other site
223283001234	beta-alpha-beta structure motif; other site
223283001235	NAD binding pocket [chemical binding]; other site
223283001236	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
223283001237	catalytic loop [active]
223283001238	iron binding site [ion binding]; other site
223283001239	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
223283001240	methionine sulfoxide reductase A; Provisional; Region: PRK00058
223283001241	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
223283001242	GAF domain; Region: GAF; pfam01590
223283001243	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283001244	PAS domain; Region: PAS_9; pfam13426
223283001245	putative active site [active]
223283001246	heme pocket [chemical binding]; other site
223283001247	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283001248	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283001249	metal binding site [ion binding]; metal-binding site
223283001250	active site
223283001251	I-site; other site
223283001252	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283001253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283001254	putative substrate translocation pore; other site
223283001255	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
223283001256	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
223283001257	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
223283001258	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
223283001259	tetramer interface [polypeptide binding]; other site
223283001260	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283001261	catalytic residue [active]
223283001262	TraX protein; Region: TraX; pfam05857
223283001263	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
223283001264	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
223283001265	putative RNA binding site [nucleotide binding]; other site
223283001266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283001267	S-adenosylmethionine binding site [chemical binding]; other site
223283001268	HDOD domain; Region: HDOD; pfam08668
223283001269	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
223283001270	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
223283001271	DNA binding site [nucleotide binding]
223283001272	catalytic residue [active]
223283001273	H2TH interface [polypeptide binding]; other site
223283001274	putative catalytic residues [active]
223283001275	turnover-facilitating residue; other site
223283001276	intercalation triad [nucleotide binding]; other site
223283001277	8OG recognition residue [nucleotide binding]; other site
223283001278	putative reading head residues; other site
223283001279	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
223283001280	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
223283001281	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
223283001282	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
223283001283	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
223283001284	active site
223283001285	(T/H)XGH motif; other site
223283001286	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
223283001287	NAD(P) binding site [chemical binding]; other site
223283001288	catalytic residues [active]
223283001289	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283001290	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283001291	Bacterial transcriptional repressor; Region: TetR; pfam13972
223283001292	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
223283001293	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
223283001294	active site residue [active]
223283001295	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
223283001296	active site residue [active]
223283001297	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
223283001298	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
223283001299	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283001300	sequence-specific DNA binding site [nucleotide binding]; other site
223283001301	salt bridge; other site
223283001302	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
223283001303	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
223283001304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283001305	S-adenosylmethionine binding site [chemical binding]; other site
223283001306	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
223283001307	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
223283001308	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
223283001309	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
223283001310	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
223283001311	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
223283001312	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
223283001313	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
223283001314	P loop; other site
223283001315	GTP binding site [chemical binding]; other site
223283001316	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
223283001317	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283001318	Walker A/P-loop; other site
223283001319	ATP binding site [chemical binding]; other site
223283001320	Q-loop/lid; other site
223283001321	ABC transporter signature motif; other site
223283001322	Walker B; other site
223283001323	D-loop; other site
223283001324	H-loop/switch region; other site
223283001325	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
223283001326	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
223283001327	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
223283001328	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283001329	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283001330	DNA binding residues [nucleotide binding]
223283001331	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
223283001332	Transglycosylase; Region: Transgly; cl17702
223283001333	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
223283001334	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
223283001335	thiS-thiF/thiG interaction site; other site
223283001336	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
223283001337	ThiS interaction site; other site
223283001338	putative active site [active]
223283001339	tetramer interface [polypeptide binding]; other site
223283001340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283001341	S-adenosylmethionine binding site [chemical binding]; other site
223283001342	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
223283001343	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
223283001344	folate binding site [chemical binding]; other site
223283001345	NADP+ binding site [chemical binding]; other site
223283001346	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
223283001347	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
223283001348	G1 box; other site
223283001349	GTP/Mg2+ binding site [chemical binding]; other site
223283001350	G2 box; other site
223283001351	Switch I region; other site
223283001352	G3 box; other site
223283001353	Switch II region; other site
223283001354	G4 box; other site
223283001355	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
223283001356	transcriptional regulator BetI; Validated; Region: PRK00767
223283001357	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283001358	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
223283001359	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
223283001360	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
223283001361	NAD(P) binding site [chemical binding]; other site
223283001362	catalytic residues [active]
223283001363	choline dehydrogenase; Validated; Region: PRK02106
223283001364	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
223283001365	RNA polymerase sigma factor; Reviewed; Region: PRK12523
223283001366	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283001367	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283001368	DNA binding residues [nucleotide binding]
223283001369	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
223283001370	FecR protein; Region: FecR; pfam04773
223283001371	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
223283001372	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
223283001373	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
223283001374	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
223283001375	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
223283001376	putative C-terminal domain interface [polypeptide binding]; other site
223283001377	putative GSH binding site (G-site) [chemical binding]; other site
223283001378	putative dimer interface [polypeptide binding]; other site
223283001379	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
223283001380	N-terminal domain interface [polypeptide binding]; other site
223283001381	dimer interface [polypeptide binding]; other site
223283001382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283001383	Transposase; Region: HTH_Tnp_1; cl17663
223283001384	putative transposase OrfB; Reviewed; Region: PHA02517
223283001385	HTH-like domain; Region: HTH_21; pfam13276
223283001386	Integrase core domain; Region: rve; pfam00665
223283001387	Integrase core domain; Region: rve_2; pfam13333
223283001388	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
223283001389	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
223283001390	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
223283001391	putative acyl-acceptor binding pocket; other site
223283001392	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
223283001393	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
223283001394	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
223283001395	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
223283001396	NAD binding site [chemical binding]; other site
223283001397	catalytic Zn binding site [ion binding]; other site
223283001398	structural Zn binding site [ion binding]; other site
223283001399	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
223283001400	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
223283001401	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
223283001402	putative active site [active]
223283001403	putative substrate binding site [chemical binding]; other site
223283001404	putative cosubstrate binding site; other site
223283001405	catalytic site [active]
223283001406	Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268
223283001407	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
223283001408	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
223283001409	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
223283001410	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
223283001411	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
223283001412	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
223283001413	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
223283001414	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
223283001415	dimer interface [polypeptide binding]; other site
223283001416	active site
223283001417	glycine-pyridoxal phosphate binding site [chemical binding]; other site
223283001418	folate binding site [chemical binding]; other site
223283001419	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
223283001420	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283001421	Walker A/P-loop; other site
223283001422	ATP binding site [chemical binding]; other site
223283001423	Q-loop/lid; other site
223283001424	ABC transporter signature motif; other site
223283001425	Walker B; other site
223283001426	D-loop; other site
223283001427	H-loop/switch region; other site
223283001428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283001429	dimer interface [polypeptide binding]; other site
223283001430	conserved gate region; other site
223283001431	putative PBP binding loops; other site
223283001432	ABC-ATPase subunit interface; other site
223283001433	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
223283001434	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
223283001435	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
223283001436	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
223283001437	conserved cys residue [active]
223283001438	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283001439	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283001440	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283001441	dimerization interface [polypeptide binding]; other site
223283001442	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283001443	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283001444	dimer interface [polypeptide binding]; other site
223283001445	putative CheW interface [polypeptide binding]; other site
223283001446	hypothetical protein; Validated; Region: PRK09039
223283001447	Cell division protein ZapA; Region: ZapA; pfam05164
223283001448	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
223283001449	active site
223283001450	catalytic site [active]
223283001451	substrate binding site [chemical binding]; other site
223283001452	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
223283001453	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
223283001454	ligand binding site [chemical binding]; other site
223283001455	flexible hinge region; other site
223283001456	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
223283001457	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
223283001458	metal binding triad; other site
223283001459	Response regulator receiver domain; Region: Response_reg; pfam00072
223283001460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283001461	active site
223283001462	phosphorylation site [posttranslational modification]
223283001463	intermolecular recognition site; other site
223283001464	dimerization interface [polypeptide binding]; other site
223283001465	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
223283001466	PAAR motif; Region: PAAR_motif; pfam05488
223283001467	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
223283001468	active site
223283001469	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
223283001470	ACT domain; Region: ACT_6; pfam13740
223283001471	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
223283001472	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
223283001473	Predicted permeases [General function prediction only]; Region: RarD; COG2962
223283001474	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
223283001475	serine/threonine protein kinase; Provisional; Region: PRK11768
223283001476	Transcriptional regulators [Transcription]; Region: PurR; COG1609
223283001477	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
223283001478	DNA binding site [nucleotide binding]
223283001479	domain linker motif; other site
223283001480	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
223283001481	putative dimerization interface [polypeptide binding]; other site
223283001482	putative ligand binding site [chemical binding]; other site
223283001483	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
223283001484	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
223283001485	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
223283001486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283001487	dimer interface [polypeptide binding]; other site
223283001488	conserved gate region; other site
223283001489	putative PBP binding loops; other site
223283001490	ABC-ATPase subunit interface; other site
223283001491	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
223283001492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283001493	dimer interface [polypeptide binding]; other site
223283001494	conserved gate region; other site
223283001495	putative PBP binding loops; other site
223283001496	ABC-ATPase subunit interface; other site
223283001497	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
223283001498	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283001499	Walker A/P-loop; other site
223283001500	ATP binding site [chemical binding]; other site
223283001501	Q-loop/lid; other site
223283001502	ABC transporter signature motif; other site
223283001503	Walker B; other site
223283001504	D-loop; other site
223283001505	H-loop/switch region; other site
223283001506	TOBE domain; Region: TOBE_2; pfam08402
223283001507	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
223283001508	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
223283001509	active site
223283001510	metal binding site [ion binding]; metal-binding site
223283001511	hexamer interface [polypeptide binding]; other site
223283001512	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
223283001513	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
223283001514	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
223283001515	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
223283001516	TOBE domain; Region: TOBE; cl01440
223283001517	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
223283001518	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
223283001519	active site
223283001520	biotin synthase; Provisional; Region: PRK15108
223283001521	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283001522	FeS/SAM binding site; other site
223283001523	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
223283001524	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
223283001525	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
223283001526	substrate-cofactor binding pocket; other site
223283001527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283001528	catalytic residue [active]
223283001529	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
223283001530	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
223283001531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283001532	S-adenosylmethionine binding site [chemical binding]; other site
223283001533	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
223283001534	AAA domain; Region: AAA_26; pfam13500
223283001535	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
223283001536	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
223283001537	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
223283001538	active site
223283001539	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
223283001540	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
223283001541	active site
223283001542	conformational flexibility of ligand binding pocket; other site
223283001543	ADP-ribosylating toxin turn-turn motif; other site
223283001544	AvrPphF-ORF-2; Region: AvrPphF-ORF-2; pfam09143
223283001545	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283001546	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283001547	metal binding site [ion binding]; metal-binding site
223283001548	active site
223283001549	I-site; other site
223283001550	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
223283001551	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
223283001552	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
223283001553	active site
223283001554	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
223283001555	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
223283001556	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
223283001557	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
223283001558	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
223283001559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283001560	FeS/SAM binding site; other site
223283001561	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
223283001562	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
223283001563	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
223283001564	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
223283001565	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
223283001566	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
223283001567	coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110
223283001568	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
223283001569	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
223283001570	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
223283001571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283001572	Transposase; Region: HTH_Tnp_1; cl17663
223283001573	putative transposase OrfB; Reviewed; Region: PHA02517
223283001574	HTH-like domain; Region: HTH_21; pfam13276
223283001575	Integrase core domain; Region: rve; pfam00665
223283001576	Integrase core domain; Region: rve_2; pfam13333
223283001577	Predicted amidohydrolase [General function prediction only]; Region: COG0388
223283001578	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
223283001579	putative active site [active]
223283001580	catalytic triad [active]
223283001581	putative dimer interface [polypeptide binding]; other site
223283001582	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
223283001583	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
223283001584	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
223283001585	putative DNA binding site [nucleotide binding]; other site
223283001586	putative Zn2+ binding site [ion binding]; other site
223283001587	AsnC family; Region: AsnC_trans_reg; pfam01037
223283001588	Predicted membrane protein [Function unknown]; Region: COG1289
223283001589	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
223283001590	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
223283001591	non-specific DNA binding site [nucleotide binding]; other site
223283001592	salt bridge; other site
223283001593	sequence-specific DNA binding site [nucleotide binding]; other site
223283001594	HipA N-terminal domain; Region: Couple_hipA; cl11853
223283001595	HipA-like N-terminal domain; Region: HipA_N; pfam07805
223283001596	HipA-like C-terminal domain; Region: HipA_C; pfam07804
223283001597	Fic family protein [Function unknown]; Region: COG3177
223283001598	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
223283001599	Fic/DOC family; Region: Fic; pfam02661
223283001600	glutamate carboxypeptidase; Reviewed; Region: PRK06133
223283001601	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
223283001602	metal binding site [ion binding]; metal-binding site
223283001603	dimer interface [polypeptide binding]; other site
223283001604	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
223283001605	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
223283001606	Type IV secretion system proteins; Region: T4SS; pfam07996
223283001607	Transposase domain (DUF772); Region: DUF772; pfam05598
223283001608	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283001609	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283001610	integrase; Provisional; Region: int; PHA02601
223283001611	Rci recombinase, C-terminal catalytic domain.  Rci enzymes are found in IncI1 incompatibility group plasmids such as R64.  These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796
223283001612	catalytic residues [active]
223283001613	Int/Topo IB signature motif; other site
223283001614	PAS domain S-box; Region: sensory_box; TIGR00229
223283001615	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283001616	putative active site [active]
223283001617	heme pocket [chemical binding]; other site
223283001618	PAS domain S-box; Region: sensory_box; TIGR00229
223283001619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283001620	putative active site [active]
223283001621	heme pocket [chemical binding]; other site
223283001622	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283001623	PAS domain; Region: PAS_9; pfam13426
223283001624	putative active site [active]
223283001625	heme pocket [chemical binding]; other site
223283001626	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283001627	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283001628	metal binding site [ion binding]; metal-binding site
223283001629	active site
223283001630	I-site; other site
223283001631	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283001632	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
223283001633	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
223283001634	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
223283001635	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
223283001636	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283001637	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
223283001638	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283001639	DNA binding residues [nucleotide binding]
223283001640	DNA primase, catalytic core; Region: dnaG; TIGR01391
223283001641	CHC2 zinc finger; Region: zf-CHC2; pfam01807
223283001642	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
223283001643	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
223283001644	active site
223283001645	metal binding site [ion binding]; metal-binding site
223283001646	interdomain interaction site; other site
223283001647	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
223283001648	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
223283001649	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
223283001650	UGMP family protein; Validated; Region: PRK09604
223283001651	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
223283001652	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
223283001653	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
223283001654	homooctamer interface [polypeptide binding]; other site
223283001655	active site
223283001656	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
223283001657	catalytic center binding site [active]
223283001658	ATP binding site [chemical binding]; other site
223283001659	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
223283001660	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
223283001661	active site
223283001662	NTP binding site [chemical binding]; other site
223283001663	metal binding triad [ion binding]; metal-binding site
223283001664	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
223283001665	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
223283001666	Zn2+ binding site [ion binding]; other site
223283001667	Mg2+ binding site [ion binding]; other site
223283001668	SpoVR family protein; Provisional; Region: PRK11767
223283001669	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
223283001670	hypothetical protein; Provisional; Region: PRK05325
223283001671	PrkA family serine protein kinase; Provisional; Region: PRK15455
223283001672	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
223283001673	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
223283001674	active site residue [active]
223283001675	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
223283001676	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
223283001677	active site
223283001678	metal binding site [ion binding]; metal-binding site
223283001679	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
223283001680	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
223283001681	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
223283001682	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
223283001683	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
223283001684	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
223283001685	SurA N-terminal domain; Region: SurA_N; pfam09312
223283001686	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
223283001687	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
223283001688	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
223283001689	OstA-like protein; Region: OstA; cl00844
223283001690	Organic solvent tolerance protein; Region: OstA_C; pfam04453
223283001691	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
223283001692	Phosphotransferase enzyme family; Region: APH; pfam01636
223283001693	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
223283001694	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
223283001695	Substrate binding site; other site
223283001696	metal-binding site
223283001697	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
223283001698	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
223283001699	putative metal binding site [ion binding]; other site
223283001700	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
223283001701	HSP70 interaction site [polypeptide binding]; other site
223283001702	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
223283001703	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
223283001704	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283001705	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283001706	substrate binding pocket [chemical binding]; other site
223283001707	membrane-bound complex binding site; other site
223283001708	hinge residues; other site
223283001709	PAS domain; Region: PAS_9; pfam13426
223283001710	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283001711	putative active site [active]
223283001712	heme pocket [chemical binding]; other site
223283001713	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
223283001714	Histidine kinase; Region: HisKA_3; pfam07730
223283001715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283001716	ATP binding site [chemical binding]; other site
223283001717	Mg2+ binding site [ion binding]; other site
223283001718	G-X-G motif; other site
223283001719	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283001720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283001721	active site
223283001722	phosphorylation site [posttranslational modification]
223283001723	intermolecular recognition site; other site
223283001724	dimerization interface [polypeptide binding]; other site
223283001725	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283001726	DNA binding residues [nucleotide binding]
223283001727	dimerization interface [polypeptide binding]; other site
223283001728	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
223283001729	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
223283001730	Walker A/P-loop; other site
223283001731	ATP binding site [chemical binding]; other site
223283001732	Q-loop/lid; other site
223283001733	ABC transporter signature motif; other site
223283001734	Walker B; other site
223283001735	D-loop; other site
223283001736	H-loop/switch region; other site
223283001737	TOBE domain; Region: TOBE_2; pfam08402
223283001738	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
223283001739	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
223283001740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283001741	dimer interface [polypeptide binding]; other site
223283001742	conserved gate region; other site
223283001743	putative PBP binding loops; other site
223283001744	ABC-ATPase subunit interface; other site
223283001745	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
223283001746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283001747	dimer interface [polypeptide binding]; other site
223283001748	conserved gate region; other site
223283001749	putative PBP binding loops; other site
223283001750	ABC-ATPase subunit interface; other site
223283001751	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
223283001752	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
223283001753	substrate binding site [chemical binding]; other site
223283001754	hexamer interface [polypeptide binding]; other site
223283001755	metal binding site [ion binding]; metal-binding site
223283001756	phosphoglycolate phosphatase; Provisional; Region: PRK13223
223283001757	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
223283001758	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283001759	motif II; other site
223283001760	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
223283001761	anthranilate synthase component I; Provisional; Region: PRK13565
223283001762	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
223283001763	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
223283001764	PYOCIN001; Putative bacteriocin; Pyocin F-like; Possible F-type Pyocin. Integrated between trpE and trpG genes like P. aeruginosa pyocin. NO capsid or head genes. Tail genes have best hits to Lambdoid phages like Coliphage P27. Note that HopPtoH and HopPtoC are just outside of this region.
223283001765	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
223283001766	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
223283001767	active site
223283001768	catalytic triad [active]
223283001769	oxyanion hole [active]
223283001770	Autotransporter beta-domain; Region: Autotransporter; pfam03797
223283001771	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
223283001772	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283001773	non-specific DNA binding site [nucleotide binding]; other site
223283001774	salt bridge; other site
223283001775	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
223283001776	sequence-specific DNA binding site [nucleotide binding]; other site
223283001777	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
223283001778	Catalytic site [active]
223283001779	Protein of unknown function (DUF812); Region: DUF812; pfam05667
223283001780	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
223283001781	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
223283001782	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
223283001783	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
223283001784	Phage tail tube protein; Region: Tail_tube; pfam10618
223283001785	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
223283001786	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
223283001787	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
223283001788	NAD-dependent deacetylase; Provisional; Region: PRK00481
223283001789	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
223283001790	NAD+ binding site [chemical binding]; other site
223283001791	substrate binding site [chemical binding]; other site
223283001792	Zn binding site [ion binding]; other site
223283001793	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
223283001794	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
223283001795	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283001796	active site
223283001797	catalytic residues [active]
223283001798	DNA binding site [nucleotide binding]
223283001799	Int/Topo IB signature motif; other site
223283001800	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283001801	active site
223283001802	catalytic residues [active]
223283001803	DNA binding site [nucleotide binding]
223283001804	Int/Topo IB signature motif; other site
223283001805	cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586
223283001806	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
223283001807	DNA binding site [nucleotide binding]
223283001808	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
223283001809	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
223283001810	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
223283001811	glutamine binding [chemical binding]; other site
223283001812	catalytic triad [active]
223283001813	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
223283001814	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
223283001815	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
223283001816	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
223283001817	active site
223283001818	ribulose/triose binding site [chemical binding]; other site
223283001819	phosphate binding site [ion binding]; other site
223283001820	substrate (anthranilate) binding pocket [chemical binding]; other site
223283001821	product (indole) binding pocket [chemical binding]; other site
223283001822	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
223283001823	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
223283001824	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
223283001825	ligand binding site [chemical binding]; other site
223283001826	flexible hinge region; other site
223283001827	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
223283001828	putative switch regulator; other site
223283001829	non-specific DNA interactions [nucleotide binding]; other site
223283001830	DNA binding site [nucleotide binding]
223283001831	sequence specific DNA binding site [nucleotide binding]; other site
223283001832	putative cAMP binding site [chemical binding]; other site
223283001833	OsmC-like protein; Region: OsmC; cl00767
223283001834	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
223283001835	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
223283001836	diiron binding motif [ion binding]; other site
223283001837	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
223283001838	nucleotide binding site/active site [active]
223283001839	HIT family signature motif; other site
223283001840	catalytic residue [active]
223283001841	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
223283001842	classical (c) SDRs; Region: SDR_c; cd05233
223283001843	NAD(P) binding site [chemical binding]; other site
223283001844	active site
223283001845	Protein of unknown function (DUF805); Region: DUF805; pfam05656
223283001846	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
223283001847	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
223283001848	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
223283001849	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
223283001850	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
223283001851	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
223283001852	putative peptidase; Provisional; Region: PRK11649
223283001853	Peptidase family M23; Region: Peptidase_M23; pfam01551
223283001854	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
223283001855	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
223283001856	active site
223283001857	HIGH motif; other site
223283001858	dimer interface [polypeptide binding]; other site
223283001859	KMSKS motif; other site
223283001860	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
223283001861	RNA binding surface [nucleotide binding]; other site
223283001862	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
223283001863	Biotin operon repressor [Transcription]; Region: BirA; COG1654
223283001864	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
223283001865	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
223283001866	pantothenate kinase; Reviewed; Region: PRK13322
223283001867	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
223283001868	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
223283001869	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
223283001870	putative homodimer interface [polypeptide binding]; other site
223283001871	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
223283001872	heterodimer interface [polypeptide binding]; other site
223283001873	homodimer interface [polypeptide binding]; other site
223283001874	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
223283001875	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
223283001876	23S rRNA interface [nucleotide binding]; other site
223283001877	L7/L12 interface [polypeptide binding]; other site
223283001878	putative thiostrepton binding site; other site
223283001879	L25 interface [polypeptide binding]; other site
223283001880	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
223283001881	mRNA/rRNA interface [nucleotide binding]; other site
223283001882	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
223283001883	23S rRNA interface [nucleotide binding]; other site
223283001884	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
223283001885	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
223283001886	peripheral dimer interface [polypeptide binding]; other site
223283001887	core dimer interface [polypeptide binding]; other site
223283001888	L10 interface [polypeptide binding]; other site
223283001889	L11 interface [polypeptide binding]; other site
223283001890	putative EF-Tu interaction site [polypeptide binding]; other site
223283001891	putative EF-G interaction site [polypeptide binding]; other site
223283001892	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
223283001893	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
223283001894	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
223283001895	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
223283001896	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
223283001897	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
223283001898	RPB3 interaction site [polypeptide binding]; other site
223283001899	RPB1 interaction site [polypeptide binding]; other site
223283001900	RPB11 interaction site [polypeptide binding]; other site
223283001901	RPB10 interaction site [polypeptide binding]; other site
223283001902	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
223283001903	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
223283001904	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
223283001905	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
223283001906	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
223283001907	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
223283001908	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
223283001909	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
223283001910	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
223283001911	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
223283001912	DNA binding site [nucleotide binding]
223283001913	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
223283001914	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
223283001915	S17 interaction site [polypeptide binding]; other site
223283001916	S8 interaction site; other site
223283001917	16S rRNA interaction site [nucleotide binding]; other site
223283001918	streptomycin interaction site [chemical binding]; other site
223283001919	23S rRNA interaction site [nucleotide binding]; other site
223283001920	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
223283001921	30S ribosomal protein S7; Validated; Region: PRK05302
223283001922	elongation factor G; Reviewed; Region: PRK00007
223283001923	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
223283001924	G1 box; other site
223283001925	putative GEF interaction site [polypeptide binding]; other site
223283001926	GTP/Mg2+ binding site [chemical binding]; other site
223283001927	Switch I region; other site
223283001928	G2 box; other site
223283001929	G3 box; other site
223283001930	Switch II region; other site
223283001931	G4 box; other site
223283001932	G5 box; other site
223283001933	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
223283001934	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
223283001935	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
223283001936	elongation factor Tu; Reviewed; Region: PRK00049
223283001937	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
223283001938	G1 box; other site
223283001939	GEF interaction site [polypeptide binding]; other site
223283001940	GTP/Mg2+ binding site [chemical binding]; other site
223283001941	Switch I region; other site
223283001942	G2 box; other site
223283001943	G3 box; other site
223283001944	Switch II region; other site
223283001945	G4 box; other site
223283001946	G5 box; other site
223283001947	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
223283001948	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
223283001949	Antibiotic Binding Site [chemical binding]; other site
223283001950	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
223283001951	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
223283001952	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
223283001953	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
223283001954	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
223283001955	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
223283001956	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
223283001957	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
223283001958	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
223283001959	protein-rRNA interface [nucleotide binding]; other site
223283001960	putative translocon binding site; other site
223283001961	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
223283001962	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
223283001963	G-X-X-G motif; other site
223283001964	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
223283001965	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
223283001966	23S rRNA interface [nucleotide binding]; other site
223283001967	5S rRNA interface [nucleotide binding]; other site
223283001968	putative antibiotic binding site [chemical binding]; other site
223283001969	L25 interface [polypeptide binding]; other site
223283001970	L27 interface [polypeptide binding]; other site
223283001971	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
223283001972	23S rRNA interface [nucleotide binding]; other site
223283001973	putative translocon interaction site; other site
223283001974	signal recognition particle (SRP54) interaction site; other site
223283001975	L23 interface [polypeptide binding]; other site
223283001976	trigger factor interaction site; other site
223283001977	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
223283001978	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
223283001979	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
223283001980	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
223283001981	RNA binding site [nucleotide binding]; other site
223283001982	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
223283001983	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
223283001984	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
223283001985	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
223283001986	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
223283001987	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
223283001988	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
223283001989	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
223283001990	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
223283001991	5S rRNA interface [nucleotide binding]; other site
223283001992	23S rRNA interface [nucleotide binding]; other site
223283001993	L5 interface [polypeptide binding]; other site
223283001994	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
223283001995	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
223283001996	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
223283001997	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
223283001998	23S rRNA binding site [nucleotide binding]; other site
223283001999	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
223283002000	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
223283002001	SecY translocase; Region: SecY; pfam00344
223283002002	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
223283002003	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
223283002004	30S ribosomal protein S13; Region: bact_S13; TIGR03631
223283002005	30S ribosomal protein S11; Validated; Region: PRK05309
223283002006	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
223283002007	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
223283002008	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
223283002009	RNA binding surface [nucleotide binding]; other site
223283002010	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
223283002011	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
223283002012	alphaNTD homodimer interface [polypeptide binding]; other site
223283002013	alphaNTD - beta interaction site [polypeptide binding]; other site
223283002014	alphaNTD - beta' interaction site [polypeptide binding]; other site
223283002015	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
223283002016	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
223283002017	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
223283002018	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
223283002019	heme binding site [chemical binding]; other site
223283002020	ferroxidase pore; other site
223283002021	ferroxidase diiron center [ion binding]; other site
223283002022	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
223283002023	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
223283002024	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
223283002025	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
223283002026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283002027	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283002028	putative substrate translocation pore; other site
223283002029	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
223283002030	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
223283002031	dimer interface [polypeptide binding]; other site
223283002032	ssDNA binding site [nucleotide binding]; other site
223283002033	tetramer (dimer of dimers) interface [polypeptide binding]; other site
223283002034	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
223283002035	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
223283002036	active site
223283002037	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
223283002038	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
223283002039	putative active site [active]
223283002040	catalytic site [active]
223283002041	putative metal binding site [ion binding]; other site
223283002042	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
223283002043	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283002044	Walker A/P-loop; other site
223283002045	ATP binding site [chemical binding]; other site
223283002046	Q-loop/lid; other site
223283002047	ABC transporter signature motif; other site
223283002048	Walker B; other site
223283002049	D-loop; other site
223283002050	H-loop/switch region; other site
223283002051	TOBE domain; Region: TOBE_2; pfam08402
223283002052	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
223283002053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283002054	dimer interface [polypeptide binding]; other site
223283002055	conserved gate region; other site
223283002056	putative PBP binding loops; other site
223283002057	ABC-ATPase subunit interface; other site
223283002058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283002059	dimer interface [polypeptide binding]; other site
223283002060	conserved gate region; other site
223283002061	putative PBP binding loops; other site
223283002062	ABC-ATPase subunit interface; other site
223283002063	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
223283002064	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
223283002065	MarR family; Region: MarR_2; pfam12802
223283002066	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
223283002067	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
223283002068	nucleotide binding site [chemical binding]; other site
223283002069	short chain dehydrogenase; Provisional; Region: PRK06924
223283002070	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283002071	NAD(P) binding site [chemical binding]; other site
223283002072	active site
223283002073	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364
223283002074	L11 interface [polypeptide binding]; other site
223283002075	putative EF-Tu interaction site [polypeptide binding]; other site
223283002076	putative EF-G interaction site [polypeptide binding]; other site
223283002077	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283002078	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283002079	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283002080	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283002081	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283002082	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283002083	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283002084	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
223283002085	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283002086	N-terminal plug; other site
223283002087	ligand-binding site [chemical binding]; other site
223283002088	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
223283002089	TolR protein; Region: tolR; TIGR02801
223283002090	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
223283002091	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
223283002092	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
223283002093	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
223283002094	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
223283002095	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
223283002096	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
223283002097	Mechanosensitive ion channel; Region: MS_channel; pfam00924
223283002098	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
223283002099	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283002100	NAD(P) binding site [chemical binding]; other site
223283002101	active site
223283002102	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283002103	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
223283002104	NAD(P) binding site [chemical binding]; other site
223283002105	active site
223283002106	OmpW family; Region: OmpW; cl17427
223283002107	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
223283002108	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
223283002109	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
223283002110	FtsX-like permease family; Region: FtsX; pfam02687
223283002111	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
223283002112	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
223283002113	Walker A/P-loop; other site
223283002114	ATP binding site [chemical binding]; other site
223283002115	Q-loop/lid; other site
223283002116	ABC transporter signature motif; other site
223283002117	Walker B; other site
223283002118	D-loop; other site
223283002119	H-loop/switch region; other site
223283002120	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
223283002121	SnoaL-like domain; Region: SnoaL_2; pfam12680
223283002122	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
223283002123	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
223283002124	Predicted methyltransferase [General function prediction only]; Region: COG3897
223283002125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283002126	S-adenosylmethionine binding site [chemical binding]; other site
223283002127	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
223283002128	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
223283002129	ATP cone domain; Region: ATP-cone; pfam03477
223283002130	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
223283002131	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
223283002132	catalytic motif [active]
223283002133	Zn binding site [ion binding]; other site
223283002134	RibD C-terminal domain; Region: RibD_C; cl17279
223283002135	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
223283002136	Lumazine binding domain; Region: Lum_binding; pfam00677
223283002137	Lumazine binding domain; Region: Lum_binding; pfam00677
223283002138	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
223283002139	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
223283002140	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
223283002141	dimerization interface [polypeptide binding]; other site
223283002142	active site
223283002143	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
223283002144	homopentamer interface [polypeptide binding]; other site
223283002145	active site
223283002146	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
223283002147	putative RNA binding site [nucleotide binding]; other site
223283002148	thiamine monophosphate kinase; Provisional; Region: PRK05731
223283002149	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
223283002150	ATP binding site [chemical binding]; other site
223283002151	dimerization interface [polypeptide binding]; other site
223283002152	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
223283002153	dimerization interface [polypeptide binding]; other site
223283002154	active site
223283002155	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
223283002156	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
223283002157	TPP-binding site; other site
223283002158	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
223283002159	PYR/PP interface [polypeptide binding]; other site
223283002160	dimer interface [polypeptide binding]; other site
223283002161	TPP binding site [chemical binding]; other site
223283002162	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
223283002163	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
223283002164	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
223283002165	substrate binding pocket [chemical binding]; other site
223283002166	chain length determination region; other site
223283002167	substrate-Mg2+ binding site; other site
223283002168	catalytic residues [active]
223283002169	aspartate-rich region 1; other site
223283002170	active site lid residues [active]
223283002171	aspartate-rich region 2; other site
223283002172	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
223283002173	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
223283002174	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
223283002175	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283002176	catalytic residue [active]
223283002177	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
223283002178	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
223283002179	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
223283002180	putative S-transferase; Provisional; Region: PRK11752
223283002181	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
223283002182	C-terminal domain interface [polypeptide binding]; other site
223283002183	GSH binding site (G-site) [chemical binding]; other site
223283002184	dimer interface [polypeptide binding]; other site
223283002185	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
223283002186	dimer interface [polypeptide binding]; other site
223283002187	N-terminal domain interface [polypeptide binding]; other site
223283002188	active site
223283002189	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
223283002190	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
223283002191	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
223283002192	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
223283002193	Walker A/P-loop; other site
223283002194	ATP binding site [chemical binding]; other site
223283002195	Q-loop/lid; other site
223283002196	ABC transporter signature motif; other site
223283002197	Walker B; other site
223283002198	D-loop; other site
223283002199	H-loop/switch region; other site
223283002200	GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183
223283002201	Ligand binding site; other site
223283002202	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584
223283002203	putative active site [active]
223283002204	catalytic site [active]
223283002205	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
223283002206	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283002207	motif II; other site
223283002208	GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183
223283002209	Ligand binding site; other site
223283002210	WavE lipopolysaccharide synthesis; Region: WavE; pfam07507
223283002211	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
223283002212	Autotransporter beta-domain; Region: Autotransporter; pfam03797
223283002213	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
223283002214	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283002215	non-specific DNA binding site [nucleotide binding]; other site
223283002216	salt bridge; other site
223283002217	sequence-specific DNA binding site [nucleotide binding]; other site
223283002218	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283002219	non-specific DNA binding site [nucleotide binding]; other site
223283002220	salt bridge; other site
223283002221	sequence-specific DNA binding site [nucleotide binding]; other site
223283002222	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283002223	salt bridge; other site
223283002224	non-specific DNA binding site [nucleotide binding]; other site
223283002225	sequence-specific DNA binding site [nucleotide binding]; other site
223283002226	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283002227	non-specific DNA binding site [nucleotide binding]; other site
223283002228	salt bridge; other site
223283002229	sequence-specific DNA binding site [nucleotide binding]; other site
223283002230	Predicted transcriptional regulator [Transcription]; Region: COG2932
223283002231	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
223283002232	Catalytic site [active]
223283002233	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
223283002234	dimer interface [polypeptide binding]; other site
223283002235	substrate binding site [chemical binding]; other site
223283002236	metal binding sites [ion binding]; metal-binding site
223283002237	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
223283002238	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
223283002239	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
223283002240	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
223283002241	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283002242	Coenzyme A binding pocket [chemical binding]; other site
223283002243	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
223283002244	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
223283002245	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
223283002246	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
223283002247	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
223283002248	NAD(P) binding site [chemical binding]; other site
223283002249	catalytic residues [active]
223283002250	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
223283002251	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
223283002252	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
223283002253	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
223283002254	aromatic acid decarboxylase; Validated; Region: PRK05920
223283002255	Flavoprotein; Region: Flavoprotein; pfam02441
223283002256	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
223283002257	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
223283002258	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
223283002259	NAD binding site [chemical binding]; other site
223283002260	active site
223283002261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
223283002262	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
223283002263	Peptidase C13 family; Region: Peptidase_C13; cl02159
223283002264	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
223283002265	putative active site [active]
223283002266	putative catalytic site [active]
223283002267	LrgA family; Region: LrgA; cl00608
223283002268	LrgB-like family; Region: LrgB; pfam04172
223283002269	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
223283002270	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
223283002271	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
223283002272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283002273	S-adenosylmethionine binding site [chemical binding]; other site
223283002274	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
223283002275	homodimer interface [polypeptide binding]; other site
223283002276	chemical substrate binding site [chemical binding]; other site
223283002277	oligomer interface [polypeptide binding]; other site
223283002278	metal binding site [ion binding]; metal-binding site
223283002279	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
223283002280	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
223283002281	active site 2 [active]
223283002282	active site 1 [active]
223283002283	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
223283002284	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283002285	NAD(P) binding site [chemical binding]; other site
223283002286	active site
223283002287	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
223283002288	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
223283002289	dimer interface [polypeptide binding]; other site
223283002290	active site
223283002291	Protein of unknown function (DUF726); Region: DUF726; pfam05277
223283002292	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
223283002293	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
223283002294	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
223283002295	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
223283002296	ATP binding site [chemical binding]; other site
223283002297	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
223283002298	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
223283002299	DNA binding residues [nucleotide binding]
223283002300	dimer interface [polypeptide binding]; other site
223283002301	copper binding site [ion binding]; other site
223283002302	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
223283002303	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
223283002304	metal-binding site [ion binding]
223283002305	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
223283002306	Soluble P-type ATPase [General function prediction only]; Region: COG4087
223283002307	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
223283002308	metal-binding site [ion binding]
223283002309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283002310	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
223283002311	putative substrate translocation pore; other site
223283002312	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
223283002313	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
223283002314	putative NAD(P) binding site [chemical binding]; other site
223283002315	dimer interface [polypeptide binding]; other site
223283002316	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283002317	transcriptional activator TtdR; Provisional; Region: PRK09801
223283002318	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
223283002319	putative effector binding pocket; other site
223283002320	dimerization interface [polypeptide binding]; other site
223283002321	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283002322	putative DNA binding site [nucleotide binding]; other site
223283002323	putative Zn2+ binding site [ion binding]; other site
223283002324	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
223283002325	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
223283002326	active site
223283002327	purine riboside binding site [chemical binding]; other site
223283002328	oxidase reductase; Provisional; Region: PTZ00273
223283002329	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
223283002330	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
223283002331	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
223283002332	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
223283002333	putative ligand binding site [chemical binding]; other site
223283002334	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
223283002335	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
223283002336	Walker A/P-loop; other site
223283002337	ATP binding site [chemical binding]; other site
223283002338	Q-loop/lid; other site
223283002339	ABC transporter signature motif; other site
223283002340	Walker B; other site
223283002341	D-loop; other site
223283002342	H-loop/switch region; other site
223283002343	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
223283002344	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
223283002345	ABC-ATPase subunit  interface; other site
223283002346	dimer interface [polypeptide binding]; other site
223283002347	putative PBP binding regions; other site
223283002348	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
223283002349	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
223283002350	putative PBP binding regions; other site
223283002351	ABC-ATPase subunit  interface; other site
223283002352	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
223283002353	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
223283002354	siderophore binding site; other site
223283002355	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
223283002356	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
223283002357	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
223283002358	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
223283002359	active site
223283002360	putative substrate binding pocket [chemical binding]; other site
223283002361	short chain dehydrogenase; Provisional; Region: PRK08177
223283002362	C factor cell-cell signaling protein; Provisional; Region: PRK09009
223283002363	NAD(P) binding site [chemical binding]; other site
223283002364	active site
223283002365	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283002366	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
223283002367	TM-ABC transporter signature motif; other site
223283002368	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283002369	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
223283002370	TM-ABC transporter signature motif; other site
223283002371	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
223283002372	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
223283002373	Walker A/P-loop; other site
223283002374	ATP binding site [chemical binding]; other site
223283002375	Q-loop/lid; other site
223283002376	ABC transporter signature motif; other site
223283002377	Walker B; other site
223283002378	D-loop; other site
223283002379	H-loop/switch region; other site
223283002380	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
223283002381	Uncharacterized conserved protein [Function unknown]; Region: COG1739
223283002382	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
223283002383	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
223283002384	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
223283002385	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283002386	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
223283002387	xanthine permease; Region: pbuX; TIGR03173
223283002388	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
223283002389	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283002390	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283002391	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
223283002392	dimerization interface [polypeptide binding]; other site
223283002393	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
223283002394	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283002395	inhibitor-cofactor binding pocket; inhibition site
223283002396	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283002397	catalytic residue [active]
223283002398	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
223283002399	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
223283002400	tetrameric interface [polypeptide binding]; other site
223283002401	NAD binding site [chemical binding]; other site
223283002402	catalytic residues [active]
223283002403	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
223283002404	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
223283002405	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
223283002406	Part of AAA domain; Region: AAA_19; pfam13245
223283002407	Family description; Region: UvrD_C_2; pfam13538
223283002408	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
223283002409	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
223283002410	AAA domain; Region: AAA_30; pfam13604
223283002411	Family description; Region: UvrD_C_2; pfam13538
223283002412	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
223283002413	Transposase domain (DUF772); Region: DUF772; pfam05598
223283002414	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283002415	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283002416	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283002417	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283002418	LysR substrate binding domain; Region: LysR_substrate; pfam03466
223283002419	dimerization interface [polypeptide binding]; other site
223283002420	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
223283002421	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
223283002422	tetrameric interface [polypeptide binding]; other site
223283002423	NAD binding site [chemical binding]; other site
223283002424	catalytic residues [active]
223283002425	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
223283002426	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
223283002427	enterobactin receptor protein; Provisional; Region: PRK13483
223283002428	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283002429	N-terminal plug; other site
223283002430	ligand-binding site [chemical binding]; other site
223283002431	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283002432	dimerization interface [polypeptide binding]; other site
223283002433	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283002434	dimer interface [polypeptide binding]; other site
223283002435	phosphorylation site [posttranslational modification]
223283002436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283002437	ATP binding site [chemical binding]; other site
223283002438	Mg2+ binding site [ion binding]; other site
223283002439	G-X-G motif; other site
223283002440	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
223283002441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283002442	active site
223283002443	phosphorylation site [posttranslational modification]
223283002444	intermolecular recognition site; other site
223283002445	dimerization interface [polypeptide binding]; other site
223283002446	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283002447	DNA binding site [nucleotide binding]
223283002448	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
223283002449	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
223283002450	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
223283002451	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283002452	dimer interface [polypeptide binding]; other site
223283002453	conserved gate region; other site
223283002454	putative PBP binding loops; other site
223283002455	ABC-ATPase subunit interface; other site
223283002456	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
223283002457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283002458	dimer interface [polypeptide binding]; other site
223283002459	conserved gate region; other site
223283002460	putative PBP binding loops; other site
223283002461	ABC-ATPase subunit interface; other site
223283002462	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
223283002463	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283002464	Walker A/P-loop; other site
223283002465	ATP binding site [chemical binding]; other site
223283002466	Q-loop/lid; other site
223283002467	ABC transporter signature motif; other site
223283002468	Walker B; other site
223283002469	D-loop; other site
223283002470	H-loop/switch region; other site
223283002471	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
223283002472	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283002473	substrate binding pocket [chemical binding]; other site
223283002474	membrane-bound complex binding site; other site
223283002475	hinge residues; other site
223283002476	selenophosphate synthetase; Provisional; Region: PRK00943
223283002477	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
223283002478	dimerization interface [polypeptide binding]; other site
223283002479	putative ATP binding site [chemical binding]; other site
223283002480	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
223283002481	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
223283002482	active site residue [active]
223283002483	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
223283002484	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
223283002485	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
223283002486	substrate binding pocket [chemical binding]; other site
223283002487	chain length determination region; other site
223283002488	substrate-Mg2+ binding site; other site
223283002489	catalytic residues [active]
223283002490	aspartate-rich region 1; other site
223283002491	active site lid residues [active]
223283002492	aspartate-rich region 2; other site
223283002493	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
223283002494	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
223283002495	GTPase CgtA; Reviewed; Region: obgE; PRK12298
223283002496	GTP1/OBG; Region: GTP1_OBG; pfam01018
223283002497	Obg GTPase; Region: Obg; cd01898
223283002498	G1 box; other site
223283002499	GTP/Mg2+ binding site [chemical binding]; other site
223283002500	Switch I region; other site
223283002501	G2 box; other site
223283002502	G3 box; other site
223283002503	Switch II region; other site
223283002504	G4 box; other site
223283002505	G5 box; other site
223283002506	gamma-glutamyl kinase; Provisional; Region: PRK05429
223283002507	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
223283002508	nucleotide binding site [chemical binding]; other site
223283002509	homotetrameric interface [polypeptide binding]; other site
223283002510	putative phosphate binding site [ion binding]; other site
223283002511	putative allosteric binding site; other site
223283002512	PUA domain; Region: PUA; pfam01472
223283002513	CreA protein; Region: CreA; pfam05981
223283002514	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
223283002515	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
223283002516	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
223283002517	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
223283002518	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
223283002519	active site
223283002520	Riboflavin kinase; Region: Flavokinase; pfam01687
223283002521	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
223283002522	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
223283002523	active site
223283002524	HIGH motif; other site
223283002525	nucleotide binding site [chemical binding]; other site
223283002526	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
223283002527	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
223283002528	active site
223283002529	KMSKS motif; other site
223283002530	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
223283002531	tRNA binding surface [nucleotide binding]; other site
223283002532	anticodon binding site; other site
223283002533	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
223283002534	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
223283002535	lipoprotein signal peptidase; Provisional; Region: PRK14787
223283002536	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
223283002537	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
223283002538	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
223283002539	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
223283002540	Type II transport protein GspH; Region: GspH; pfam12019
223283002541	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
223283002542	Type II transport protein GspH; Region: GspH; pfam12019
223283002543	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
223283002544	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
223283002545	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
223283002546	PilX N-terminal; Region: PilX_N; pfam14341
223283002547	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
223283002548	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
223283002549	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
223283002550	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
223283002551	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
223283002552	Transcriptional regulators [Transcription]; Region: MarR; COG1846
223283002553	MarR family; Region: MarR; pfam01047
223283002554	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
223283002555	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
223283002556	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
223283002557	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
223283002558	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283002559	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283002560	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283002561	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283002562	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
223283002563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283002564	active site
223283002565	phosphorylation site [posttranslational modification]
223283002566	intermolecular recognition site; other site
223283002567	dimerization interface [polypeptide binding]; other site
223283002568	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283002569	Walker A motif; other site
223283002570	ATP binding site [chemical binding]; other site
223283002571	Walker B motif; other site
223283002572	arginine finger; other site
223283002573	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283002574	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
223283002575	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283002576	dimer interface [polypeptide binding]; other site
223283002577	phosphorylation site [posttranslational modification]
223283002578	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283002579	ATP binding site [chemical binding]; other site
223283002580	Mg2+ binding site [ion binding]; other site
223283002581	G-X-G motif; other site
223283002582	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
223283002583	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
223283002584	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
223283002585	RNA binding surface [nucleotide binding]; other site
223283002586	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
223283002587	active site
223283002588	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
223283002589	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
223283002590	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
223283002591	Clp amino terminal domain; Region: Clp_N; pfam02861
223283002592	Clp amino terminal domain; Region: Clp_N; pfam02861
223283002593	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283002594	Walker A motif; other site
223283002595	ATP binding site [chemical binding]; other site
223283002596	Walker B motif; other site
223283002597	arginine finger; other site
223283002598	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283002599	Walker A motif; other site
223283002600	ATP binding site [chemical binding]; other site
223283002601	Walker B motif; other site
223283002602	arginine finger; other site
223283002603	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
223283002604	ICEland; putative integrative and onjugative element, degenerate; includes genes for type III effectors HopAJ1, HopAT1', HopD1, HopQ1-1, and HopR1
223283002605	Putative helicase; Region: TraI_2; pfam07514
223283002606	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
223283002607	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
223283002608	transposase/IS protein; Provisional; Region: PRK09183
223283002609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283002610	Walker A motif; other site
223283002611	ATP binding site [chemical binding]; other site
223283002612	Walker B motif; other site
223283002613	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283002614	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283002615	DNA-binding interface [nucleotide binding]; DNA binding site
223283002616	Integrase core domain; Region: rve; pfam00665
223283002617	Integrase core domain; Region: rve_3; cl15866
223283002618	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
223283002619	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
223283002620	NAD(P) binding site [chemical binding]; other site
223283002621	RibD C-terminal domain; Region: RibD_C; cl17279
223283002622	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
223283002623	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
223283002624	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283002625	motif II; other site
223283002626	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
223283002627	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283002628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283002629	putative substrate translocation pore; other site
223283002630	Protein of unknown function (DUF3742); Region: DUF3742; pfam12553
223283002631	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283002632	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283002633	Transposase domain (DUF772); Region: DUF772; pfam05598
223283002634	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283002635	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283002636	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
223283002637	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
223283002638	Protein of unknown function (DUF1525); Region: DUF1525; pfam07511
223283002639	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
223283002640	lytic murein transglycosylase; Region: MltB_2; TIGR02283
223283002641	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283002642	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283002643	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
223283002644	Global regulator protein family; Region: CsrA; pfam02599
223283002645	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
223283002646	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
223283002647	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
223283002648	P-loop; other site
223283002649	Magnesium ion binding site [ion binding]; other site
223283002650	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
223283002651	Magnesium ion binding site [ion binding]; other site
223283002652	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
223283002653	synthetase active site [active]
223283002654	NTP binding site [chemical binding]; other site
223283002655	metal binding site [ion binding]; metal-binding site
223283002656	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
223283002657	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
223283002658	catalytic residues [active]
223283002659	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
223283002660	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
223283002661	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
223283002662	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
223283002663	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
223283002664	Protein of unknown function (DUF972); Region: DUF972; pfam06156
223283002665	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
223283002666	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
223283002667	transposase/IS protein; Provisional; Region: PRK09183
223283002668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283002669	Walker A motif; other site
223283002670	ATP binding site [chemical binding]; other site
223283002671	Walker B motif; other site
223283002672	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283002673	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283002674	DNA-binding interface [nucleotide binding]; DNA binding site
223283002675	Integrase core domain; Region: rve; pfam00665
223283002676	Integrase core domain; Region: rve_3; cl15866
223283002677	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
223283002678	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
223283002679	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
223283002680	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
223283002681	H+ Antiporter protein; Region: 2A0121; TIGR00900
223283002682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283002683	putative substrate translocation pore; other site
223283002684	GMP synthase C terminal domain; Region: GMP_synt_C; pfam00958
223283002685	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
223283002686	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
223283002687	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
223283002688	NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652
223283002689	active site
223283002690	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
223283002691	Family description; Region: UvrD_C_2; pfam13538
223283002692	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
223283002693	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
223283002694	Transcriptional regulators [Transcription]; Region: PurR; COG1609
223283002695	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
223283002696	DNA binding site [nucleotide binding]
223283002697	domain linker motif; other site
223283002698	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
223283002699	putative dimerization interface [polypeptide binding]; other site
223283002700	putative ligand binding site [chemical binding]; other site
223283002701	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
223283002702	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
223283002703	substrate binding [chemical binding]; other site
223283002704	active site
223283002705	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
223283002706	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
223283002707	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
223283002708	Walker A/P-loop; other site
223283002709	ATP binding site [chemical binding]; other site
223283002710	Q-loop/lid; other site
223283002711	ABC transporter signature motif; other site
223283002712	Walker B; other site
223283002713	D-loop; other site
223283002714	H-loop/switch region; other site
223283002715	TOBE domain; Region: TOBE_2; pfam08402
223283002716	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
223283002717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283002718	dimer interface [polypeptide binding]; other site
223283002719	conserved gate region; other site
223283002720	putative PBP binding loops; other site
223283002721	ABC-ATPase subunit interface; other site
223283002722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283002723	dimer interface [polypeptide binding]; other site
223283002724	conserved gate region; other site
223283002725	putative PBP binding loops; other site
223283002726	ABC-ATPase subunit interface; other site
223283002727	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
223283002728	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
223283002729	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
223283002730	trimer interface; other site
223283002731	sugar binding site [chemical binding]; other site
223283002732	Autotransporter beta-domain; Region: Autotransporter; pfam03797
223283002733	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
223283002734	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283002735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283002736	dimer interface [polypeptide binding]; other site
223283002737	phosphorylation site [posttranslational modification]
223283002738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283002739	ATP binding site [chemical binding]; other site
223283002740	Mg2+ binding site [ion binding]; other site
223283002741	G-X-G motif; other site
223283002742	Response regulator receiver domain; Region: Response_reg; pfam00072
223283002743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283002744	active site
223283002745	phosphorylation site [posttranslational modification]
223283002746	intermolecular recognition site; other site
223283002747	dimerization interface [polypeptide binding]; other site
223283002748	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283002749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283002750	active site
223283002751	phosphorylation site [posttranslational modification]
223283002752	intermolecular recognition site; other site
223283002753	dimerization interface [polypeptide binding]; other site
223283002754	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283002755	DNA binding residues [nucleotide binding]
223283002756	dimerization interface [polypeptide binding]; other site
223283002757	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283002758	dimer interface [polypeptide binding]; other site
223283002759	phosphorylation site [posttranslational modification]
223283002760	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
223283002761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283002762	ATP binding site [chemical binding]; other site
223283002763	Mg2+ binding site [ion binding]; other site
223283002764	G-X-G motif; other site
223283002765	Response regulator receiver domain; Region: Response_reg; pfam00072
223283002766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283002767	active site
223283002768	phosphorylation site [posttranslational modification]
223283002769	intermolecular recognition site; other site
223283002770	dimerization interface [polypeptide binding]; other site
223283002771	Transposase domain (DUF772); Region: DUF772; pfam05598
223283002772	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283002773	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283002774	Transposase domain (DUF772); Region: DUF772; pfam05598
223283002775	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283002776	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283002777	type III effector phosphothreonine lyase; Provisional; Region: PRK15245
223283002778	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
223283002779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283002780	active site
223283002781	phosphorylation site [posttranslational modification]
223283002782	intermolecular recognition site; other site
223283002783	dimerization interface [polypeptide binding]; other site
223283002784	CheB methylesterase; Region: CheB_methylest; pfam01339
223283002785	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13498
223283002786	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
223283002787	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
223283002788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283002789	S-adenosylmethionine binding site [chemical binding]; other site
223283002790	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
223283002791	putative CheA interaction surface; other site
223283002792	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283002793	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283002794	dimerization interface [polypeptide binding]; other site
223283002795	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283002796	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283002797	dimer interface [polypeptide binding]; other site
223283002798	putative CheW interface [polypeptide binding]; other site
223283002799	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
223283002800	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
223283002801	putative binding surface; other site
223283002802	active site
223283002803	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
223283002804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283002805	ATP binding site [chemical binding]; other site
223283002806	Mg2+ binding site [ion binding]; other site
223283002807	G-X-G motif; other site
223283002808	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
223283002809	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
223283002810	anti sigma factor interaction site; other site
223283002811	regulatory phosphorylation site [posttranslational modification]; other site
223283002812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283002813	Response regulator receiver domain; Region: Response_reg; pfam00072
223283002814	active site
223283002815	phosphorylation site [posttranslational modification]
223283002816	intermolecular recognition site; other site
223283002817	dimerization interface [polypeptide binding]; other site
223283002818	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
223283002819	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283002820	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283002821	Protein of unknown function (DUF3094); Region: DUF3094; pfam11293
223283002822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
223283002823	MOSC domain; Region: MOSC; pfam03473
223283002824	Protein of unknown function (DUF1780); Region: DUF1780; pfam08682
223283002825	DNA gyrase inhibitor; Reviewed; Region: PRK00418
223283002826	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
223283002827	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
223283002828	CoA-binding site [chemical binding]; other site
223283002829	ATP-binding [chemical binding]; other site
223283002830	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
223283002831	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
223283002832	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
223283002833	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
223283002834	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
223283002835	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
223283002836	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
223283002837	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
223283002838	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
223283002839	Walker A motif; other site
223283002840	ATP binding site [chemical binding]; other site
223283002841	Walker B motif; other site
223283002842	putative major pilin subunit; Provisional; Region: PRK10574
223283002843	Predicted transcriptional regulators [Transcription]; Region: COG1733
223283002844	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
223283002845	glutathionine S-transferase; Provisional; Region: PRK10542
223283002846	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
223283002847	C-terminal domain interface [polypeptide binding]; other site
223283002848	GSH binding site (G-site) [chemical binding]; other site
223283002849	dimer interface [polypeptide binding]; other site
223283002850	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
223283002851	dimer interface [polypeptide binding]; other site
223283002852	N-terminal domain interface [polypeptide binding]; other site
223283002853	substrate binding pocket (H-site) [chemical binding]; other site
223283002854	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
223283002855	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
223283002856	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
223283002857	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
223283002858	putative metal binding site [ion binding]; other site
223283002859	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
223283002860	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
223283002861	active site
223283002862	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
223283002863	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
223283002864	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
223283002865	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
223283002866	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
223283002867	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
223283002868	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
223283002869	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
223283002870	putative metal binding site [ion binding]; other site
223283002871	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
223283002872	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
223283002873	putative metal binding site [ion binding]; other site
223283002874	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
223283002875	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
223283002876	putative metal binding site [ion binding]; other site
223283002877	tellurite resistance protein terB; Region: terB; cd07176
223283002878	putative metal binding site [ion binding]; other site
223283002879	Integral membrane protein TerC family; Region: TerC; cl10468
223283002880	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
223283002881	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
223283002882	putative metal binding site [ion binding]; other site
223283002883	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
223283002884	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
223283002885	putative metal binding site [ion binding]; other site
223283002886	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
223283002887	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
223283002888	putative metal binding site [ion binding]; other site
223283002889	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
223283002890	metal ion-dependent adhesion site (MIDAS); other site
223283002891	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
223283002892	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
223283002893	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
223283002894	dimerization interface [polypeptide binding]; other site
223283002895	active site
223283002896	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
223283002897	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
223283002898	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
223283002899	amidase catalytic site [active]
223283002900	Zn binding residues [ion binding]; other site
223283002901	substrate binding site [chemical binding]; other site
223283002902	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
223283002903	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
223283002904	active site
223283002905	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
223283002906	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
223283002907	DNA binding site [nucleotide binding]
223283002908	domain linker motif; other site
223283002909	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
223283002910	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
223283002911	active site
223283002912	phosphorylation site [posttranslational modification]
223283002913	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
223283002914	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
223283002915	dimerization domain swap beta strand [polypeptide binding]; other site
223283002916	regulatory protein interface [polypeptide binding]; other site
223283002917	active site
223283002918	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
223283002919	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
223283002920	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
223283002921	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
223283002922	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
223283002923	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
223283002924	putative substrate binding site [chemical binding]; other site
223283002925	putative ATP binding site [chemical binding]; other site
223283002926	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
223283002927	active site
223283002928	P-loop; other site
223283002929	phosphorylation site [posttranslational modification]
223283002930	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
223283002931	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
223283002932	active site
223283002933	P-loop; other site
223283002934	phosphorylation site [posttranslational modification]
223283002935	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
223283002936	acetyl-CoA acetyltransferase; Provisional; Region: PRK05656
223283002937	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
223283002938	dimer interface [polypeptide binding]; other site
223283002939	active site
223283002940	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
223283002941	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
223283002942	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
223283002943	active site
223283002944	dimer interface [polypeptide binding]; other site
223283002945	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
223283002946	dimer interface [polypeptide binding]; other site
223283002947	active site
223283002948	Pantoate-beta-alanine ligase; Region: PanC; cd00560
223283002949	pantoate--beta-alanine ligase; Region: panC; TIGR00018
223283002950	active site
223283002951	ATP-binding site [chemical binding]; other site
223283002952	pantoate-binding site; other site
223283002953	HXXH motif; other site
223283002954	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
223283002955	oligomerization interface [polypeptide binding]; other site
223283002956	active site
223283002957	metal binding site [ion binding]; metal-binding site
223283002958	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
223283002959	catalytic center binding site [active]
223283002960	ATP binding site [chemical binding]; other site
223283002961	poly(A) polymerase; Region: pcnB; TIGR01942
223283002962	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
223283002963	active site
223283002964	NTP binding site [chemical binding]; other site
223283002965	metal binding triad [ion binding]; metal-binding site
223283002966	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
223283002967	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
223283002968	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
223283002969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283002970	active site
223283002971	phosphorylation site [posttranslational modification]
223283002972	intermolecular recognition site; other site
223283002973	dimerization interface [polypeptide binding]; other site
223283002974	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283002975	Walker A motif; other site
223283002976	ATP binding site [chemical binding]; other site
223283002977	Walker B motif; other site
223283002978	arginine finger; other site
223283002979	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
223283002980	Na binding site [ion binding]; other site
223283002981	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
223283002982	PAS domain; Region: PAS; smart00091
223283002983	putative active site [active]
223283002984	heme pocket [chemical binding]; other site
223283002985	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283002986	dimer interface [polypeptide binding]; other site
223283002987	phosphorylation site [posttranslational modification]
223283002988	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283002989	ATP binding site [chemical binding]; other site
223283002990	Mg2+ binding site [ion binding]; other site
223283002991	G-X-G motif; other site
223283002992	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
223283002993	active site
223283002994	nucleotide binding site [chemical binding]; other site
223283002995	HIGH motif; other site
223283002996	KMSKS motif; other site
223283002997	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283002998	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283002999	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283003000	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
223283003001	hypothetical protein; Provisional; Region: PRK08960
223283003002	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283003003	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283003004	homodimer interface [polypeptide binding]; other site
223283003005	catalytic residue [active]
223283003006	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
223283003007	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
223283003008	iron-sulfur cluster [ion binding]; other site
223283003009	[2Fe-2S] cluster binding site [ion binding]; other site
223283003010	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
223283003011	intersubunit interface [polypeptide binding]; other site
223283003012	active site
223283003013	catalytic residue [active]
223283003014	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
223283003015	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
223283003016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
223283003017	AAA domain; Region: AAA_33; pfam13671
223283003018	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
223283003019	ATP-binding site [chemical binding]; other site
223283003020	Gluconate-6-phosphate binding site [chemical binding]; other site
223283003021	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
223283003022	Transglycosylase; Region: Transgly; pfam00912
223283003023	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
223283003024	Tetratricopeptide repeat; Region: TPR_16; pfam13432
223283003025	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
223283003026	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
223283003027	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
223283003028	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
223283003029	PYR/PP interface [polypeptide binding]; other site
223283003030	dimer interface [polypeptide binding]; other site
223283003031	TPP binding site [chemical binding]; other site
223283003032	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
223283003033	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
223283003034	TPP-binding site [chemical binding]; other site
223283003035	dimer interface [polypeptide binding]; other site
223283003036	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
223283003037	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
223283003038	putative valine binding site [chemical binding]; other site
223283003039	dimer interface [polypeptide binding]; other site
223283003040	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
223283003041	ketol-acid reductoisomerase; Provisional; Region: PRK05479
223283003042	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
223283003043	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
223283003044	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
223283003045	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
223283003046	TMAO/DMSO reductase; Reviewed; Region: PRK05363
223283003047	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
223283003048	Moco binding site; other site
223283003049	metal coordination site [ion binding]; other site
223283003050	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
223283003051	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
223283003052	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
223283003053	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
223283003054	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
223283003055	Coenzyme A binding pocket [chemical binding]; other site
223283003056	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
223283003057	active site clefts [active]
223283003058	zinc binding site [ion binding]; other site
223283003059	dimer interface [polypeptide binding]; other site
223283003060	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283003061	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
223283003062	dimerization interface [polypeptide binding]; other site
223283003063	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283003064	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283003065	dimer interface [polypeptide binding]; other site
223283003066	putative CheW interface [polypeptide binding]; other site
223283003067	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
223283003068	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
223283003069	Zn2+ binding site [ion binding]; other site
223283003070	Mg2+ binding site [ion binding]; other site
223283003071	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
223283003072	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
223283003073	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
223283003074	PhnA protein; Region: PhnA; pfam03831
223283003075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283003076	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283003077	putative substrate translocation pore; other site
223283003078	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
223283003079	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
223283003080	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
223283003081	metal binding site [ion binding]; metal-binding site
223283003082	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
223283003083	putative active site [active]
223283003084	putative metal binding site [ion binding]; other site
223283003085	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283003086	Coenzyme A binding pocket [chemical binding]; other site
223283003087	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283003088	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283003089	metal binding site [ion binding]; metal-binding site
223283003090	active site
223283003091	I-site; other site
223283003092	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
223283003093	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
223283003094	NADP-binding site; other site
223283003095	homotetramer interface [polypeptide binding]; other site
223283003096	substrate binding site [chemical binding]; other site
223283003097	homodimer interface [polypeptide binding]; other site
223283003098	active site
223283003099	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
223283003100	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
223283003101	NADP-binding site; other site
223283003102	homotetramer interface [polypeptide binding]; other site
223283003103	substrate binding site [chemical binding]; other site
223283003104	homodimer interface [polypeptide binding]; other site
223283003105	active site
223283003106	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
223283003107	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283003108	putative active site [active]
223283003109	heme pocket [chemical binding]; other site
223283003110	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283003111	putative active site [active]
223283003112	heme pocket [chemical binding]; other site
223283003113	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283003114	dimer interface [polypeptide binding]; other site
223283003115	putative CheW interface [polypeptide binding]; other site
223283003116	Isochorismatase family; Region: Isochorismatase; pfam00857
223283003117	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
223283003118	catalytic triad [active]
223283003119	dimer interface [polypeptide binding]; other site
223283003120	conserved cis-peptide bond; other site
223283003121	PhoD-like phosphatase; Region: PhoD; pfam09423
223283003122	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
223283003123	putative active site [active]
223283003124	putative metal binding site [ion binding]; other site
223283003125	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
223283003126	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
223283003127	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
223283003128	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
223283003129	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
223283003130	Gram-negative bacterial tonB protein; Region: TonB; cl10048
223283003131	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283003132	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283003133	N-terminal plug; other site
223283003134	ligand-binding site [chemical binding]; other site
223283003135	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
223283003136	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
223283003137	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283003138	active site
223283003139	catalytic residues [active]
223283003140	DNA binding site [nucleotide binding]
223283003141	Int/Topo IB signature motif; other site
223283003142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283003143	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283003144	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283003145	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283003146	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283003147	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283003148	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283003149	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283003150	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283003151	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
223283003152	Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106
223283003153	PLD-like domain; Region: PLDc_2; pfam13091
223283003154	putative active site [active]
223283003155	putative catalytic site [active]
223283003156	Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107
223283003157	PLD-like domain; Region: PLDc_2; pfam13091
223283003158	putative active site [active]
223283003159	putative catalytic site [active]
223283003160	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
223283003161	MltA specific insert domain; Region: MltA; smart00925
223283003162	3D domain; Region: 3D; pfam06725
223283003163	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
223283003164	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
223283003165	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
223283003166	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
223283003167	DXD motif; other site
223283003168	PilZ domain; Region: PilZ; pfam07238
223283003169	cellulose synthase regulator protein; Provisional; Region: PRK11114
223283003170	endo-1,4-D-glucanase; Provisional; Region: PRK11097
223283003171	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
223283003172	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283003173	binding surface
223283003174	TPR motif; other site
223283003175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283003176	TPR motif; other site
223283003177	binding surface
223283003178	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283003179	binding surface
223283003180	TPR motif; other site
223283003181	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
223283003182	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
223283003183	active site
223283003184	catalytic triad [active]
223283003185	oxyanion hole [active]
223283003186	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
223283003187	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
223283003188	S-type Pyocin; Region: Pyocin_S; pfam06958
223283003189	RES domain; Region: RES; cl02411
223283003190	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
223283003191	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
223283003192	Response regulator receiver domain; Region: Response_reg; pfam00072
223283003193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283003194	active site
223283003195	phosphorylation site [posttranslational modification]
223283003196	intermolecular recognition site; other site
223283003197	dimerization interface [polypeptide binding]; other site
223283003198	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
223283003199	PAS fold; Region: PAS_4; pfam08448
223283003200	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
223283003201	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
223283003202	hinge; other site
223283003203	active site
223283003204	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
223283003205	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
223283003206	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
223283003207	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283003208	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283003209	DNA binding residues [nucleotide binding]
223283003210	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
223283003211	oligomeric interface; other site
223283003212	putative active site [active]
223283003213	homodimer interface [polypeptide binding]; other site
223283003214	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
223283003215	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
223283003216	active site
223283003217	catalytic residues [active]
223283003218	DctM-like transporters; Region: DctM; pfam06808
223283003219	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
223283003220	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
223283003221	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
223283003222	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
223283003223	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
223283003224	Strictosidine synthase; Region: Str_synth; pfam03088
223283003225	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
223283003226	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283003227	active site
223283003228	outer membrane porin, OprD family; Region: OprD; pfam03573
223283003229	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
223283003230	classical (c) SDRs; Region: SDR_c; cd05233
223283003231	NAD(P) binding site [chemical binding]; other site
223283003232	active site
223283003233	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569
223283003234	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283003235	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283003236	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283003237	dimerization interface [polypeptide binding]; other site
223283003238	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283003239	dimer interface [polypeptide binding]; other site
223283003240	putative CheW interface [polypeptide binding]; other site
223283003241	Cache domain; Region: Cache_1; pfam02743
223283003242	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283003243	dimerization interface [polypeptide binding]; other site
223283003244	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283003245	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283003246	dimer interface [polypeptide binding]; other site
223283003247	putative CheW interface [polypeptide binding]; other site
223283003248	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
223283003249	HSP70 interaction site [polypeptide binding]; other site
223283003250	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283003251	HAMP domain; Region: HAMP; pfam00672
223283003252	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283003253	dimer interface [polypeptide binding]; other site
223283003254	putative CheW interface [polypeptide binding]; other site
223283003255	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
223283003256	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
223283003257	Probable Catalytic site; other site
223283003258	Predicted membrane protein [Function unknown]; Region: COG2246
223283003259	GtrA-like protein; Region: GtrA; pfam04138
223283003260	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
223283003261	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
223283003262	putative trimer interface [polypeptide binding]; other site
223283003263	putative active site [active]
223283003264	putative substrate binding site [chemical binding]; other site
223283003265	putative CoA binding site [chemical binding]; other site
223283003266	WxcM-like, C-terminal; Region: FdtA; pfam05523
223283003267	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
223283003268	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
223283003269	Ligand binding site; other site
223283003270	Putative Catalytic site; other site
223283003271	DXD motif; other site
223283003272	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
223283003273	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
223283003274	inhibitor-cofactor binding pocket; inhibition site
223283003275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283003276	catalytic residue [active]
223283003277	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
223283003278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283003279	S-adenosylmethionine binding site [chemical binding]; other site
223283003280	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
223283003281	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
223283003282	Probable Catalytic site; other site
223283003283	metal-binding site
223283003284	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
223283003285	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
223283003286	Probable Catalytic site; other site
223283003287	metal-binding site
223283003288	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
223283003289	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
223283003290	Walker A/P-loop; other site
223283003291	ATP binding site [chemical binding]; other site
223283003292	Q-loop/lid; other site
223283003293	ABC transporter signature motif; other site
223283003294	Walker B; other site
223283003295	D-loop; other site
223283003296	H-loop/switch region; other site
223283003297	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
223283003298	putative carbohydrate binding site [chemical binding]; other site
223283003299	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
223283003300	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
223283003301	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
223283003302	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
223283003303	Probable Catalytic site; other site
223283003304	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
223283003305	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
223283003306	substrate binding site; other site
223283003307	tetramer interface; other site
223283003308	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
223283003309	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
223283003310	NADP binding site [chemical binding]; other site
223283003311	active site
223283003312	putative substrate binding site [chemical binding]; other site
223283003313	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
223283003314	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
223283003315	NAD binding site [chemical binding]; other site
223283003316	substrate binding site [chemical binding]; other site
223283003317	homodimer interface [polypeptide binding]; other site
223283003318	active site
223283003319	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
223283003320	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
223283003321	Catalytic site [active]
223283003322	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
223283003323	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
223283003324	active site
223283003325	DNA binding site [nucleotide binding]
223283003326	Int/Topo IB signature motif; other site
223283003327	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
223283003328	HsdM N-terminal domain; Region: HsdM_N; pfam12161
223283003329	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
223283003330	Methyltransferase domain; Region: Methyltransf_26; pfam13659
223283003331	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
223283003332	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
223283003333	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
223283003334	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
223283003335	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
223283003336	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
223283003337	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
223283003338	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283003339	ATP binding site [chemical binding]; other site
223283003340	putative Mg++ binding site [ion binding]; other site
223283003341	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
223283003342	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
223283003343	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
223283003344	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
223283003345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283003346	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283003347	DNA-binding interface [nucleotide binding]; DNA binding site
223283003348	Integrase core domain; Region: rve; pfam00665
223283003349	Integrase core domain; Region: rve_3; cl15866
223283003350	transposase/IS protein; Provisional; Region: PRK09183
223283003351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283003352	Walker A motif; other site
223283003353	ATP binding site [chemical binding]; other site
223283003354	Walker B motif; other site
223283003355	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
223283003356	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283003357	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283003358	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283003359	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283003360	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283003361	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283003362	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283003363	integrase; Provisional; Region: PRK09692
223283003364	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
223283003365	active site
223283003366	Int/Topo IB signature motif; other site
223283003367	GTP-binding protein YchF; Reviewed; Region: PRK09601
223283003368	YchF GTPase; Region: YchF; cd01900
223283003369	G1 box; other site
223283003370	GTP/Mg2+ binding site [chemical binding]; other site
223283003371	Switch I region; other site
223283003372	G2 box; other site
223283003373	Switch II region; other site
223283003374	G3 box; other site
223283003375	G4 box; other site
223283003376	G5 box; other site
223283003377	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
223283003378	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
223283003379	putative active site [active]
223283003380	catalytic residue [active]
223283003381	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
223283003382	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
223283003383	5S rRNA interface [nucleotide binding]; other site
223283003384	CTC domain interface [polypeptide binding]; other site
223283003385	L16 interface [polypeptide binding]; other site
223283003386	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
223283003387	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
223283003388	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
223283003389	active site
223283003390	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
223283003391	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
223283003392	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
223283003393	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
223283003394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283003395	TPR motif; other site
223283003396	binding surface
223283003397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283003398	binding surface
223283003399	TPR motif; other site
223283003400	TPR repeat; Region: TPR_11; pfam13414
223283003401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283003402	binding surface
223283003403	TPR motif; other site
223283003404	TPR repeat; Region: TPR_11; pfam13414
223283003405	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
223283003406	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
223283003407	tRNA; other site
223283003408	putative tRNA binding site [nucleotide binding]; other site
223283003409	putative NADP binding site [chemical binding]; other site
223283003410	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
223283003411	peptide chain release factor 1; Validated; Region: prfA; PRK00591
223283003412	This domain is found in peptide chain release factors; Region: PCRF; smart00937
223283003413	RF-1 domain; Region: RF-1; pfam00472
223283003414	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
223283003415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283003416	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
223283003417	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
223283003418	ATP binding site [chemical binding]; other site
223283003419	substrate interface [chemical binding]; other site
223283003420	glutamate racemase; Provisional; Region: PRK00865
223283003421	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
223283003422	Flagellin N-methylase; Region: FliB; pfam03692
223283003423	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
223283003424	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
223283003425	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283003426	S-adenosylmethionine binding site [chemical binding]; other site
223283003427	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
223283003428	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
223283003429	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
223283003430	hydroxyglutarate oxidase; Provisional; Region: PRK11728
223283003431	short chain dehydrogenase; Provisional; Region: PRK06101
223283003432	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283003433	NAD(P) binding site [chemical binding]; other site
223283003434	active site
223283003435	SnoaL-like domain; Region: SnoaL_2; pfam12680
223283003436	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
223283003437	DNA photolyase; Region: DNA_photolyase; pfam00875
223283003438	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
223283003439	DNA binding residues [nucleotide binding]
223283003440	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
223283003441	B12 binding domain; Region: B12-binding_2; pfam02607
223283003442	Protein of unknown function (DUF523); Region: DUF523; pfam04463
223283003443	Uncharacterized conserved protein [Function unknown]; Region: COG3272
223283003444	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
223283003445	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
223283003446	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
223283003447	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
223283003448	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283003449	NAD(P) binding site [chemical binding]; other site
223283003450	active site
223283003451	ferrochelatase; Reviewed; Region: hemH; PRK00035
223283003452	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
223283003453	C-terminal domain interface [polypeptide binding]; other site
223283003454	active site
223283003455	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
223283003456	active site
223283003457	N-terminal domain interface [polypeptide binding]; other site
223283003458	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
223283003459	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
223283003460	active site
223283003461	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
223283003462	active site
223283003463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
223283003464	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283003465	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283003466	dimer interface [polypeptide binding]; other site
223283003467	ABC-ATPase subunit interface; other site
223283003468	putative PBP binding loops; other site
223283003469	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283003470	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283003471	substrate binding pocket [chemical binding]; other site
223283003472	membrane-bound complex binding site; other site
223283003473	hinge residues; other site
223283003474	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
223283003475	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
223283003476	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
223283003477	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
223283003478	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
223283003479	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
223283003480	putative acyl-acceptor binding pocket; other site
223283003481	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
223283003482	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
223283003483	Uncharacterized conserved protein [Function unknown]; Region: COG2135
223283003484	Peptidase family M48; Region: Peptidase_M48; pfam01435
223283003485	Predicted membrane protein [Function unknown]; Region: COG2119
223283003486	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
223283003487	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
223283003488	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
223283003489	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
223283003490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283003491	S-adenosylmethionine binding site [chemical binding]; other site
223283003492	LysE type translocator; Region: LysE; cl00565
223283003493	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
223283003494	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
223283003495	dimer interface [polypeptide binding]; other site
223283003496	acyl-activating enzyme (AAE) consensus motif; other site
223283003497	putative active site [active]
223283003498	AMP binding site [chemical binding]; other site
223283003499	putative CoA binding site [chemical binding]; other site
223283003500	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
223283003501	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
223283003502	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
223283003503	AAA ATPase domain; Region: AAA_16; pfam13191
223283003504	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283003505	DNA binding residues [nucleotide binding]
223283003506	dimerization interface [polypeptide binding]; other site
223283003507	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
223283003508	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
223283003509	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
223283003510	Zn2+ binding site [ion binding]; other site
223283003511	Mg2+ binding site [ion binding]; other site
223283003512	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
223283003513	pyrimidine utilization protein D; Region: RutD; TIGR03611
223283003514	TAP-like protein; Region: Abhydrolase_4; pfam08386
223283003515	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
223283003516	homotrimer interaction site [polypeptide binding]; other site
223283003517	putative active site [active]
223283003518	Isochorismatase family; Region: Isochorismatase; pfam00857
223283003519	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
223283003520	catalytic triad [active]
223283003521	conserved cis-peptide bond; other site
223283003522	pyrimidine utilization protein A; Region: RutA; TIGR03612
223283003523	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
223283003524	active site
223283003525	dimer interface [polypeptide binding]; other site
223283003526	non-prolyl cis peptide bond; other site
223283003527	insertion regions; other site
223283003528	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
223283003529	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283003530	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
223283003531	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
223283003532	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
223283003533	putative ligand binding site [chemical binding]; other site
223283003534	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
223283003535	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
223283003536	Walker A/P-loop; other site
223283003537	ATP binding site [chemical binding]; other site
223283003538	Q-loop/lid; other site
223283003539	ABC transporter signature motif; other site
223283003540	Walker B; other site
223283003541	D-loop; other site
223283003542	H-loop/switch region; other site
223283003543	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
223283003544	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
223283003545	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
223283003546	ligand binding site [chemical binding]; other site
223283003547	Transposase domain (DUF772); Region: DUF772; pfam05598
223283003548	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283003549	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283003550	GAD-like domain; Region: GAD-like; pfam08887
223283003551	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
223283003552	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
223283003553	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
223283003554	putative acyl-acceptor binding pocket; other site
223283003555	phosphate acetyltransferase; Reviewed; Region: PRK05632
223283003556	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
223283003557	DRTGG domain; Region: DRTGG; pfam07085
223283003558	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
223283003559	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
223283003560	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
223283003561	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
223283003562	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
223283003563	catalytic residues [active]
223283003564	dimer interface [polypeptide binding]; other site
223283003565	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
223283003566	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
223283003567	putative active site [active]
223283003568	putative FMN binding site [chemical binding]; other site
223283003569	putative substrate binding site [chemical binding]; other site
223283003570	putative catalytic residue [active]
223283003571	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
223283003572	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
223283003573	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283003574	putative sulfate transport protein CysZ; Validated; Region: PRK04949
223283003575	thioredoxin reductase; Provisional; Region: PRK10262
223283003576	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283003577	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283003578	HopJ type III effector protein; Region: HopJ; pfam08888
223283003579	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
223283003580	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
223283003581	homooctamer interface [polypeptide binding]; other site
223283003582	active site
223283003583	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
223283003584	homodecamer interface [polypeptide binding]; other site
223283003585	GTP cyclohydrolase I; Provisional; Region: PLN03044
223283003586	active site
223283003587	putative catalytic site residues [active]
223283003588	zinc binding site [ion binding]; other site
223283003589	GTP-CH-I/GFRP interaction surface; other site
223283003590	dihydromonapterin reductase; Provisional; Region: PRK06483
223283003591	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
223283003592	NADP binding site [chemical binding]; other site
223283003593	substrate binding pocket [chemical binding]; other site
223283003594	active site
223283003595	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
223283003596	flavodoxin; Provisional; Region: PRK05723
223283003597	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
223283003598	homodimer interface [polypeptide binding]; other site
223283003599	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
223283003600	NAD binding site [chemical binding]; other site
223283003601	active site
223283003602	Transposase domain (DUF772); Region: DUF772; pfam05598
223283003603	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283003604	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283003605	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283003606	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283003607	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283003608	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283003609	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283003610	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283003611	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283003612	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
223283003613	Tetratricopeptide repeat; Region: TPR_9; pfam13371
223283003614	hypothetical protein; Provisional; Region: PRK09936
223283003615	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
223283003616	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
223283003617	active site
223283003618	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
223283003619	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
223283003620	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
223283003621	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
223283003622	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
223283003623	active site
223283003624	homodimer interface [polypeptide binding]; other site
223283003625	YebG protein; Region: YebG; pfam07130
223283003626	Predicted membrane protein [Function unknown]; Region: COG3223
223283003627	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
223283003628	RNA polymerase sigma factor; Provisional; Region: PRK12528
223283003629	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283003630	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283003631	DNA binding residues [nucleotide binding]
223283003632	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
223283003633	FecR protein; Region: FecR; pfam04773
223283003634	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
223283003635	30S subunit binding site; other site
223283003636	Secretin and TonB N terminus short domain; Region: STN; smart00965
223283003637	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
223283003638	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283003639	N-terminal plug; other site
223283003640	ligand-binding site [chemical binding]; other site
223283003641	Secretin and TonB N terminus short domain; Region: STN; smart00965
223283003642	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
223283003643	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283003644	N-terminal plug; other site
223283003645	ligand-binding site [chemical binding]; other site
223283003646	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
223283003647	FecR protein; Region: FecR; pfam04773
223283003648	RNA polymerase sigma factor; Provisional; Region: PRK12528
223283003649	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283003650	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283003651	DNA binding residues [nucleotide binding]
223283003652	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
223283003653	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
223283003654	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
223283003655	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
223283003656	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283003657	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
223283003658	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283003659	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
223283003660	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
223283003661	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
223283003662	dimerization interface [polypeptide binding]; other site
223283003663	ligand binding site [chemical binding]; other site
223283003664	NADP binding site [chemical binding]; other site
223283003665	catalytic site [active]
223283003666	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283003667	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283003668	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
223283003669	putative effector binding pocket; other site
223283003670	dimerization interface [polypeptide binding]; other site
223283003671	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
223283003672	Fusaric acid resistance protein family; Region: FUSC; pfam04632
223283003673	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
223283003674	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
223283003675	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
223283003676	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283003677	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283003678	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
223283003679	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
223283003680	short chain dehydrogenase; Provisional; Region: PRK05693
223283003681	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
223283003682	NADP binding site [chemical binding]; other site
223283003683	active site
223283003684	steroid binding site; other site
223283003685	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283003686	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283003687	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283003688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283003689	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283003690	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283003691	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283003692	Transposase domain (DUF772); Region: DUF772; pfam05598
223283003693	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283003694	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283003695	Cupin domain; Region: Cupin_2; cl17218
223283003696	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
223283003697	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
223283003698	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
223283003699	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
223283003700	Substrate binding site; other site
223283003701	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
223283003702	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
223283003703	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
223283003704	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244
223283003705	active site
223283003706	Right handed beta helix region; Region: Beta_helix; pfam13229
223283003707	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
223283003708	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
223283003709	Sel1-like repeats; Region: SEL1; smart00671
223283003710	PilZ domain; Region: PilZ; pfam07238
223283003711	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283003712	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
223283003713	active site
223283003714	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
223283003715	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
223283003716	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
223283003717	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
223283003718	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
223283003719	hypothetical protein; Validated; Region: PRK02101
223283003720	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
223283003721	NodB motif; other site
223283003722	active site
223283003723	catalytic site [active]
223283003724	metal binding site [ion binding]; metal-binding site
223283003725	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
223283003726	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
223283003727	putative active site [active]
223283003728	PhoH-like protein; Region: PhoH; pfam02562
223283003729	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
223283003730	trimer interface [polypeptide binding]; other site
223283003731	dimer interface [polypeptide binding]; other site
223283003732	putative active site [active]
223283003733	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
223283003734	MoaE interaction surface [polypeptide binding]; other site
223283003735	MoeB interaction surface [polypeptide binding]; other site
223283003736	thiocarboxylated glycine; other site
223283003737	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
223283003738	MoaE homodimer interface [polypeptide binding]; other site
223283003739	MoaD interaction [polypeptide binding]; other site
223283003740	active site residues [active]
223283003741	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
223283003742	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
223283003743	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
223283003744	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
223283003745	DEAD-like helicases superfamily; Region: DEXDc; smart00487
223283003746	ATP binding site [chemical binding]; other site
223283003747	Mg++ binding site [ion binding]; other site
223283003748	motif III; other site
223283003749	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283003750	nucleotide binding region [chemical binding]; other site
223283003751	ATP-binding site [chemical binding]; other site
223283003752	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
223283003753	putative hydrolase; Provisional; Region: PRK11460
223283003754	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283003755	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
223283003756	substrate binding pocket [chemical binding]; other site
223283003757	membrane-bound complex binding site; other site
223283003758	hinge residues; other site
223283003759	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
223283003760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283003761	conserved gate region; other site
223283003762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283003763	dimer interface [polypeptide binding]; other site
223283003764	conserved gate region; other site
223283003765	putative PBP binding loops; other site
223283003766	ABC-ATPase subunit interface; other site
223283003767	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283003768	dimer interface [polypeptide binding]; other site
223283003769	conserved gate region; other site
223283003770	putative PBP binding loops; other site
223283003771	ABC-ATPase subunit interface; other site
223283003772	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
223283003773	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283003774	Walker A/P-loop; other site
223283003775	ATP binding site [chemical binding]; other site
223283003776	Q-loop/lid; other site
223283003777	ABC transporter signature motif; other site
223283003778	Walker B; other site
223283003779	D-loop; other site
223283003780	H-loop/switch region; other site
223283003781	cyanate transporter; Region: CynX; TIGR00896
223283003782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283003783	putative substrate translocation pore; other site
223283003784	SnoaL-like domain; Region: SnoaL_3; pfam13474
223283003785	SnoaL-like domain; Region: SnoaL_2; pfam12680
223283003786	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
223283003787	GIY-YIG motif/motif A; other site
223283003788	putative active site [active]
223283003789	putative metal binding site [ion binding]; other site
223283003790	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
223283003791	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
223283003792	C-terminal domain interface [polypeptide binding]; other site
223283003793	GSH binding site (G-site) [chemical binding]; other site
223283003794	dimer interface [polypeptide binding]; other site
223283003795	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
223283003796	N-terminal domain interface [polypeptide binding]; other site
223283003797	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
223283003798	catalytic residues [active]
223283003799	Nucleoid-associated protein [General function prediction only]; Region: COG3081
223283003800	nucleoid-associated protein NdpA; Validated; Region: PRK00378
223283003801	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
223283003802	IHF dimer interface [polypeptide binding]; other site
223283003803	IHF - DNA interface [nucleotide binding]; other site
223283003804	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
223283003805	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
223283003806	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
223283003807	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
223283003808	HIGH motif; other site
223283003809	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
223283003810	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
223283003811	active site
223283003812	KMSKS motif; other site
223283003813	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
223283003814	tRNA binding surface [nucleotide binding]; other site
223283003815	anticodon binding site; other site
223283003816	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
223283003817	DNA polymerase III subunit chi; Validated; Region: PRK05728
223283003818	multifunctional aminopeptidase A; Provisional; Region: PRK00913
223283003819	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
223283003820	interface (dimer of trimers) [polypeptide binding]; other site
223283003821	Substrate-binding/catalytic site; other site
223283003822	Zn-binding sites [ion binding]; other site
223283003823	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
223283003824	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
223283003825	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
223283003826	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
223283003827	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
223283003828	DNA-binding site [nucleotide binding]; DNA binding site
223283003829	RNA-binding motif; other site
223283003830	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
223283003831	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
223283003832	glycine dehydrogenase; Provisional; Region: PRK05367
223283003833	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
223283003834	tetramer interface [polypeptide binding]; other site
223283003835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283003836	catalytic residue [active]
223283003837	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
223283003838	tetramer interface [polypeptide binding]; other site
223283003839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283003840	catalytic residue [active]
223283003841	glycine cleavage system protein H; Provisional; Region: PRK13380
223283003842	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
223283003843	lipoyl attachment site [posttranslational modification]; other site
223283003844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283003845	active site
223283003846	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
223283003847	phosphorylation site [posttranslational modification]
223283003848	intermolecular recognition site; other site
223283003849	dimerization interface [polypeptide binding]; other site
223283003850	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283003851	putative active site [active]
223283003852	heme pocket [chemical binding]; other site
223283003853	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283003854	metal binding site [ion binding]; metal-binding site
223283003855	active site
223283003856	I-site; other site
223283003857	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283003858	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
223283003859	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
223283003860	putative aromatic amino acid binding site; other site
223283003861	PAS domain; Region: PAS; smart00091
223283003862	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283003863	Walker A motif; other site
223283003864	ATP binding site [chemical binding]; other site
223283003865	Walker B motif; other site
223283003866	arginine finger; other site
223283003867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
223283003868	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
223283003869	heme binding pocket [chemical binding]; other site
223283003870	heme ligand [chemical binding]; other site
223283003871	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
223283003872	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283003873	N-terminal plug; other site
223283003874	ligand-binding site [chemical binding]; other site
223283003875	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
223283003876	FecR protein; Region: FecR; pfam04773
223283003877	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
223283003878	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283003879	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
223283003880	DNA binding residues [nucleotide binding]
223283003881	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
223283003882	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
223283003883	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
223283003884	phosphogluconate dehydratase; Validated; Region: PRK09054
223283003885	6-phosphogluconate dehydratase; Region: edd; TIGR01196
223283003886	glucokinase, proteobacterial type; Region: glk; TIGR00749
223283003887	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
223283003888	nucleotide binding site [chemical binding]; other site
223283003889	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
223283003890	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
223283003891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283003892	active site
223283003893	phosphorylation site [posttranslational modification]
223283003894	intermolecular recognition site; other site
223283003895	dimerization interface [polypeptide binding]; other site
223283003896	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283003897	DNA binding site [nucleotide binding]
223283003898	HAMP domain; Region: HAMP; pfam00672
223283003899	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283003900	dimer interface [polypeptide binding]; other site
223283003901	phosphorylation site [posttranslational modification]
223283003902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283003903	ATP binding site [chemical binding]; other site
223283003904	Mg2+ binding site [ion binding]; other site
223283003905	G-X-G motif; other site
223283003906	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
223283003907	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
223283003908	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
223283003909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283003910	ABC-ATPase subunit interface; other site
223283003911	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
223283003912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283003913	dimer interface [polypeptide binding]; other site
223283003914	conserved gate region; other site
223283003915	putative PBP binding loops; other site
223283003916	ABC-ATPase subunit interface; other site
223283003917	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
223283003918	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
223283003919	Walker A/P-loop; other site
223283003920	ATP binding site [chemical binding]; other site
223283003921	Q-loop/lid; other site
223283003922	ABC transporter signature motif; other site
223283003923	Walker B; other site
223283003924	D-loop; other site
223283003925	H-loop/switch region; other site
223283003926	TOBE domain; Region: TOBE_2; pfam08402
223283003927	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
223283003928	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
223283003929	active site
223283003930	phosphate binding residues; other site
223283003931	catalytic residues [active]
223283003932	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
223283003933	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
223283003934	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
223283003935	putative active site [active]
223283003936	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
223283003937	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
223283003938	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
223283003939	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
223283003940	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
223283003941	putative active site [active]
223283003942	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
223283003943	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
223283003944	active site
223283003945	intersubunit interface [polypeptide binding]; other site
223283003946	catalytic residue [active]
223283003947	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
223283003948	conserved hypothetical protein; Region: TIGR02284
223283003949	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283003950	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283003951	metal binding site [ion binding]; metal-binding site
223283003952	active site
223283003953	I-site; other site
223283003954	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
223283003955	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
223283003956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283003957	dimer interface [polypeptide binding]; other site
223283003958	phosphorylation site [posttranslational modification]
223283003959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283003960	ATP binding site [chemical binding]; other site
223283003961	Mg2+ binding site [ion binding]; other site
223283003962	G-X-G motif; other site
223283003963	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
223283003964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283003965	active site
223283003966	phosphorylation site [posttranslational modification]
223283003967	intermolecular recognition site; other site
223283003968	dimerization interface [polypeptide binding]; other site
223283003969	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283003970	DNA binding site [nucleotide binding]
223283003971	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
223283003972	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
223283003973	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283003974	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283003975	Transposase domain (DUF772); Region: DUF772; pfam05598
223283003976	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283003977	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283003978	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
223283003979	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
223283003980	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
223283003981	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
223283003982	Transposase domain (DUF772); Region: DUF772; pfam05598
223283003983	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283003984	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283003985	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
223283003986	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
223283003987	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
223283003988	Fimbrial protein; Region: Fimbrial; pfam00419
223283003989	Flagellin N-methylase; Region: FliB; pfam03692
223283003990	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
223283003991	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283003992	Coenzyme A binding pocket [chemical binding]; other site
223283003993	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
223283003994	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283003995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283003996	active site
223283003997	phosphorylation site [posttranslational modification]
223283003998	intermolecular recognition site; other site
223283003999	dimerization interface [polypeptide binding]; other site
223283004000	disulfide bond formation protein B; Provisional; Region: PRK02110
223283004001	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
223283004002	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
223283004003	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
223283004004	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
223283004005	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
223283004006	D-pathway; other site
223283004007	Putative ubiquinol binding site [chemical binding]; other site
223283004008	Low-spin heme (heme b) binding site [chemical binding]; other site
223283004009	Putative water exit pathway; other site
223283004010	Binuclear center (heme o3/CuB) [ion binding]; other site
223283004011	K-pathway; other site
223283004012	Putative proton exit pathway; other site
223283004013	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
223283004014	Subunit I/III interface [polypeptide binding]; other site
223283004015	Subunit III/IV interface [polypeptide binding]; other site
223283004016	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
223283004017	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
223283004018	UbiA prenyltransferase family; Region: UbiA; pfam01040
223283004019	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
223283004020	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
223283004021	active site
223283004022	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
223283004023	trimer interface [polypeptide binding]; other site
223283004024	active site
223283004025	substrate binding site [chemical binding]; other site
223283004026	CoA binding site [chemical binding]; other site
223283004027	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
223283004028	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
223283004029	homodimer interface [polypeptide binding]; other site
223283004030	substrate-cofactor binding pocket; other site
223283004031	catalytic residue [active]
223283004032	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283004033	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283004034	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283004035	dimer interface [polypeptide binding]; other site
223283004036	putative CheW interface [polypeptide binding]; other site
223283004037	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283004038	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283004039	substrate binding pocket [chemical binding]; other site
223283004040	membrane-bound complex binding site; other site
223283004041	hinge residues; other site
223283004042	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283004043	dimerization interface [polypeptide binding]; other site
223283004044	putative DNA binding site [nucleotide binding]; other site
223283004045	putative Zn2+ binding site [ion binding]; other site
223283004046	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
223283004047	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
223283004048	putative NAD(P) binding site [chemical binding]; other site
223283004049	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
223283004050	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
223283004051	E-class dimer interface [polypeptide binding]; other site
223283004052	P-class dimer interface [polypeptide binding]; other site
223283004053	active site
223283004054	Cu2+ binding site [ion binding]; other site
223283004055	Zn2+ binding site [ion binding]; other site
223283004056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283004057	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283004058	putative substrate translocation pore; other site
223283004059	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
223283004060	active site clefts [active]
223283004061	zinc binding site [ion binding]; other site
223283004062	dimer interface [polypeptide binding]; other site
223283004063	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
223283004064	hypothetical protein; Provisional; Region: PRK06156
223283004065	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
223283004066	active site
223283004067	metal binding site [ion binding]; metal-binding site
223283004068	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
223283004069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283004070	PAS domain; Region: PAS_9; pfam13426
223283004071	putative active site [active]
223283004072	heme pocket [chemical binding]; other site
223283004073	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283004074	PAS domain; Region: PAS_9; pfam13426
223283004075	putative active site [active]
223283004076	heme pocket [chemical binding]; other site
223283004077	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283004078	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283004079	metal binding site [ion binding]; metal-binding site
223283004080	active site
223283004081	I-site; other site
223283004082	GntP family permease; Region: GntP_permease; pfam02447
223283004083	fructuronate transporter; Provisional; Region: PRK10034; cl15264
223283004084	PAS domain; Region: PAS; smart00091
223283004085	PAS domain; Region: PAS_9; pfam13426
223283004086	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283004087	putative active site [active]
223283004088	heme pocket [chemical binding]; other site
223283004089	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283004090	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283004091	metal binding site [ion binding]; metal-binding site
223283004092	active site
223283004093	I-site; other site
223283004094	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283004095	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
223283004096	Part of AAA domain; Region: AAA_19; pfam13245
223283004097	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
223283004098	AAA domain; Region: AAA_12; pfam13087
223283004099	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
223283004100	Peptidase family M48; Region: Peptidase_M48; cl12018
223283004101	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
223283004102	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283004103	DNA-binding site [nucleotide binding]; DNA binding site
223283004104	FCD domain; Region: FCD; pfam07729
223283004105	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
223283004106	Isochorismatase family; Region: Isochorismatase; pfam00857
223283004107	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
223283004108	catalytic triad [active]
223283004109	conserved cis-peptide bond; other site
223283004110	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
223283004111	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
223283004112	Walker A/P-loop; other site
223283004113	ATP binding site [chemical binding]; other site
223283004114	Q-loop/lid; other site
223283004115	ABC transporter signature motif; other site
223283004116	Walker B; other site
223283004117	D-loop; other site
223283004118	H-loop/switch region; other site
223283004119	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
223283004120	Isochorismatase family; Region: Isochorismatase; pfam00857
223283004121	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
223283004122	catalytic triad [active]
223283004123	conserved cis-peptide bond; other site
223283004124	formamidase; Provisional; Region: amiF; PRK13287
223283004125	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
223283004126	multimer interface [polypeptide binding]; other site
223283004127	active site
223283004128	catalytic triad [active]
223283004129	dimer interface [polypeptide binding]; other site
223283004130	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283004131	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
223283004132	TM-ABC transporter signature motif; other site
223283004133	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283004134	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
223283004135	TM-ABC transporter signature motif; other site
223283004136	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
223283004137	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
223283004138	putative ligand binding site [chemical binding]; other site
223283004139	allophanate hydrolase; Provisional; Region: PRK08186
223283004140	Amidase; Region: Amidase; cl11426
223283004141	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
223283004142	dimer interface [polypeptide binding]; other site
223283004143	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
223283004144	ligand binding site [chemical binding]; other site
223283004145	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
223283004146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283004147	putative substrate translocation pore; other site
223283004148	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283004149	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
223283004150	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
223283004151	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
223283004152	putative C-terminal domain interface [polypeptide binding]; other site
223283004153	putative GSH binding site (G-site) [chemical binding]; other site
223283004154	putative dimer interface [polypeptide binding]; other site
223283004155	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
223283004156	putative N-terminal domain interface [polypeptide binding]; other site
223283004157	putative dimer interface [polypeptide binding]; other site
223283004158	putative substrate binding pocket (H-site) [chemical binding]; other site
223283004159	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
223283004160	Coenzyme A binding pocket [chemical binding]; other site
223283004161	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
223283004162	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
223283004163	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543
223283004164	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
223283004165	Pectate lyase; Region: Pectate_lyase; pfam03211
223283004166	Tir chaperone protein (CesT) family; Region: CesT; cl08444
223283004167	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
223283004168	Pathogenicity factor; Region: AvrE; pfam11725
223283004169	MltD lipid attachment motif; Region: MLTD_N; pfam06474
223283004170	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
223283004171	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283004172	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283004173	catalytic residue [active]
223283004174	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
223283004175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283004176	Walker A motif; other site
223283004177	ATP binding site [chemical binding]; other site
223283004178	Walker B motif; other site
223283004179	arginine finger; other site
223283004180	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283004181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283004182	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
223283004183	Walker A motif; other site
223283004184	ATP binding site [chemical binding]; other site
223283004185	Walker B motif; other site
223283004186	arginine finger; other site
223283004187	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283004188	HrpA pilus formation protein; Region: HrpA_pilin; pfam09589
223283004189	HrpZ; Region: Hairpins; pfam04877
223283004190	type III secretion apparatus protein, YscI/HrpB, C-terminal domain; Region: yscI_hrpB_dom; TIGR02497
223283004191	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
223283004192	HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188
223283004193	HrpF protein; Region: HrpF; pfam06266
223283004194	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
223283004195	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
223283004196	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
223283004197	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
223283004198	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
223283004199	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
223283004200	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
223283004201	type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403
223283004202	type III secretion system protein YscR; Provisional; Region: PRK12797
223283004203	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
223283004204	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
223283004205	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
223283004206	type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546
223283004207	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
223283004208	Walker A motif; other site
223283004209	ATP binding site [chemical binding]; other site
223283004210	Walker B motif; other site
223283004211	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
223283004212	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
223283004213	phosphopeptide binding site; other site
223283004214	type III secretion protein, HrcV family; Region: hrcV; TIGR01399
223283004215	FHIPEP family; Region: FHIPEP; pfam00771
223283004216	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
223283004217	type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511
223283004218	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
223283004219	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283004220	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283004221	DNA binding residues [nucleotide binding]
223283004222	NolX protein; Region: NolX; pfam05819
223283004223	C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647
223283004224	Transposase domain (DUF772); Region: DUF772; pfam05598
223283004225	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283004226	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283004227	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
223283004228	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
223283004229	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
223283004230	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
223283004231	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
223283004232	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
223283004233	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
223283004234	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
223283004235	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
223283004236	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
223283004237	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
223283004238	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
223283004239	Protein export membrane protein; Region: SecD_SecF; pfam02355
223283004240	hypothetical protein; Provisional; Region: PRK11280
223283004241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283004242	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283004243	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283004244	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
223283004245	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
223283004246	active site
223283004247	dimerization interface [polypeptide binding]; other site
223283004248	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
223283004249	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
223283004250	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
223283004251	serine O-acetyltransferase; Region: cysE; TIGR01172
223283004252	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
223283004253	trimer interface [polypeptide binding]; other site
223283004254	active site
223283004255	substrate binding site [chemical binding]; other site
223283004256	CoA binding site [chemical binding]; other site
223283004257	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
223283004258	Rrf2 family protein; Region: rrf2_super; TIGR00738
223283004259	cysteine desulfurase; Provisional; Region: PRK14012
223283004260	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
223283004261	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283004262	catalytic residue [active]
223283004263	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
223283004264	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
223283004265	trimerization site [polypeptide binding]; other site
223283004266	active site
223283004267	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
223283004268	co-chaperone HscB; Provisional; Region: hscB; PRK00294
223283004269	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
223283004270	HSP70 interaction site [polypeptide binding]; other site
223283004271	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
223283004272	chaperone protein HscA; Provisional; Region: hscA; PRK05183
223283004273	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
223283004274	nucleotide binding site [chemical binding]; other site
223283004275	putative NEF/HSP70 interaction site [polypeptide binding]; other site
223283004276	SBD interface [polypeptide binding]; other site
223283004277	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
223283004278	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
223283004279	catalytic loop [active]
223283004280	iron binding site [ion binding]; other site
223283004281	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
223283004282	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
223283004283	active site
223283004284	multimer interface [polypeptide binding]; other site
223283004285	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
223283004286	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283004287	FeS/SAM binding site; other site
223283004288	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
223283004289	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283004290	binding surface
223283004291	TPR motif; other site
223283004292	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283004293	binding surface
223283004294	TPR motif; other site
223283004295	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
223283004296	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283004297	non-specific DNA binding site [nucleotide binding]; other site
223283004298	salt bridge; other site
223283004299	sequence-specific DNA binding site [nucleotide binding]; other site
223283004300	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
223283004301	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
223283004302	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
223283004303	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
223283004304	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
223283004305	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
223283004306	dimer interface [polypeptide binding]; other site
223283004307	motif 1; other site
223283004308	active site
223283004309	motif 2; other site
223283004310	motif 3; other site
223283004311	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
223283004312	anticodon binding site; other site
223283004313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
223283004314	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
223283004315	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
223283004316	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
223283004317	Trp docking motif [polypeptide binding]; other site
223283004318	active site
223283004319	GTP-binding protein Der; Reviewed; Region: PRK00093
223283004320	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
223283004321	G1 box; other site
223283004322	GTP/Mg2+ binding site [chemical binding]; other site
223283004323	Switch I region; other site
223283004324	G2 box; other site
223283004325	Switch II region; other site
223283004326	G3 box; other site
223283004327	G4 box; other site
223283004328	G5 box; other site
223283004329	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
223283004330	G1 box; other site
223283004331	GTP/Mg2+ binding site [chemical binding]; other site
223283004332	Switch I region; other site
223283004333	G2 box; other site
223283004334	G3 box; other site
223283004335	Switch II region; other site
223283004336	G4 box; other site
223283004337	G5 box; other site
223283004338	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283004339	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283004340	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283004341	methionine aminotransferase; Validated; Region: PRK09082
223283004342	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283004343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283004344	homodimer interface [polypeptide binding]; other site
223283004345	catalytic residue [active]
223283004346	C-N hydrolase family amidase; Provisional; Region: PRK10438
223283004347	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
223283004348	putative active site [active]
223283004349	catalytic triad [active]
223283004350	dimer interface [polypeptide binding]; other site
223283004351	multimer interface [polypeptide binding]; other site
223283004352	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
223283004353	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
223283004354	tetramer interface [polypeptide binding]; other site
223283004355	active site
223283004356	Mg2+/Mn2+ binding site [ion binding]; other site
223283004357	2-isopropylmalate synthase; Validated; Region: PRK03739
223283004358	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
223283004359	active site
223283004360	catalytic residues [active]
223283004361	metal binding site [ion binding]; metal-binding site
223283004362	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
223283004363	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
223283004364	Peptidase family M23; Region: Peptidase_M23; pfam01551
223283004365	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
223283004366	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
223283004367	generic binding surface II; other site
223283004368	generic binding surface I; other site
223283004369	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
223283004370	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
223283004371	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
223283004372	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
223283004373	active site
223283004374	GMP synthase; Reviewed; Region: guaA; PRK00074
223283004375	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
223283004376	AMP/PPi binding site [chemical binding]; other site
223283004377	candidate oxyanion hole; other site
223283004378	catalytic triad [active]
223283004379	potential glutamine specificity residues [chemical binding]; other site
223283004380	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
223283004381	ATP Binding subdomain [chemical binding]; other site
223283004382	Ligand Binding sites [chemical binding]; other site
223283004383	Dimerization subdomain; other site
223283004384	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
223283004385	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
223283004386	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
223283004387	active site
223283004388	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
223283004389	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
223283004390	active site
223283004391	Part of AAA domain; Region: AAA_19; pfam13245
223283004392	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
223283004393	AAA domain; Region: AAA_12; pfam13087
223283004394	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
223283004395	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
223283004396	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
223283004397	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
223283004398	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
223283004399	nucleoside/Zn binding site; other site
223283004400	dimer interface [polypeptide binding]; other site
223283004401	catalytic motif [active]
223283004402	Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623
223283004403	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283004404	substrate binding pocket [chemical binding]; other site
223283004405	membrane-bound complex binding site; other site
223283004406	hinge residues; other site
223283004407	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283004408	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283004409	catalytic residue [active]
223283004410	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
223283004411	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
223283004412	dimerization interface [polypeptide binding]; other site
223283004413	ATP binding site [chemical binding]; other site
223283004414	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
223283004415	dimerization interface [polypeptide binding]; other site
223283004416	ATP binding site [chemical binding]; other site
223283004417	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
223283004418	putative active site [active]
223283004419	catalytic triad [active]
223283004420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
223283004421	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
223283004422	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
223283004423	nudix motif; other site
223283004424	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
223283004425	putative active site [active]
223283004426	putative CoA binding site [chemical binding]; other site
223283004427	nudix motif; other site
223283004428	metal binding site [ion binding]; metal-binding site
223283004429	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
223283004430	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
223283004431	trimer interface [polypeptide binding]; other site
223283004432	putative metal binding site [ion binding]; other site
223283004433	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
223283004434	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
223283004435	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
223283004436	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283004437	ATP-grasp domain; Region: ATP-grasp; pfam02222
223283004438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283004439	metabolite-proton symporter; Region: 2A0106; TIGR00883
223283004440	putative substrate translocation pore; other site
223283004441	Domain of unknown function DUF21; Region: DUF21; pfam01595
223283004442	hypothetical protein; Provisional; Region: PRK11573
223283004443	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
223283004444	Transporter associated domain; Region: CorC_HlyC; smart01091
223283004445	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
223283004446	signal recognition particle protein; Provisional; Region: PRK10867
223283004447	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
223283004448	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
223283004449	P loop; other site
223283004450	GTP binding site [chemical binding]; other site
223283004451	Signal peptide binding domain; Region: SRP_SPB; pfam02978
223283004452	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
223283004453	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
223283004454	RimM N-terminal domain; Region: RimM; pfam01782
223283004455	PRC-barrel domain; Region: PRC; pfam05239
223283004456	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
223283004457	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
223283004458	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283004459	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283004460	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283004461	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
223283004462	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
223283004463	active site
223283004464	Int/Topo IB signature motif; other site
223283004465	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
223283004466	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
223283004467	dimerization domain [polypeptide binding]; other site
223283004468	dimer interface [polypeptide binding]; other site
223283004469	catalytic residues [active]
223283004470	homoserine dehydrogenase; Provisional; Region: PRK06349
223283004471	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
223283004472	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
223283004473	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
223283004474	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
223283004475	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
223283004476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283004477	catalytic residue [active]
223283004478	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
223283004479	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283004480	substrate binding pocket [chemical binding]; other site
223283004481	membrane-bound complex binding site; other site
223283004482	hinge residues; other site
223283004483	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283004484	substrate binding pocket [chemical binding]; other site
223283004485	membrane-bound complex binding site; other site
223283004486	hinge residues; other site
223283004487	PAS domain; Region: PAS; smart00091
223283004488	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283004489	dimer interface [polypeptide binding]; other site
223283004490	phosphorylation site [posttranslational modification]
223283004491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283004492	ATP binding site [chemical binding]; other site
223283004493	Mg2+ binding site [ion binding]; other site
223283004494	G-X-G motif; other site
223283004495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283004496	active site
223283004497	phosphorylation site [posttranslational modification]
223283004498	intermolecular recognition site; other site
223283004499	dimerization interface [polypeptide binding]; other site
223283004500	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
223283004501	putative binding surface; other site
223283004502	active site
223283004503	Response regulator receiver domain; Region: Response_reg; pfam00072
223283004504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283004505	active site
223283004506	phosphorylation site [posttranslational modification]
223283004507	intermolecular recognition site; other site
223283004508	dimerization interface [polypeptide binding]; other site
223283004509	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283004510	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283004511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283004512	active site
223283004513	phosphorylation site [posttranslational modification]
223283004514	intermolecular recognition site; other site
223283004515	dimerization interface [polypeptide binding]; other site
223283004516	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283004517	DNA binding residues [nucleotide binding]
223283004518	dimerization interface [polypeptide binding]; other site
223283004519	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
223283004520	conserved hypothetical protein; Region: TIGR02285
223283004521	YaeQ protein; Region: YaeQ; pfam07152
223283004522	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
223283004523	DHH family; Region: DHH; pfam01368
223283004524	DHHA1 domain; Region: DHHA1; pfam02272
223283004525	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
223283004526	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
223283004527	active site
223283004528	FMN binding site [chemical binding]; other site
223283004529	substrate binding site [chemical binding]; other site
223283004530	homotetramer interface [polypeptide binding]; other site
223283004531	catalytic residue [active]
223283004532	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
223283004533	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
223283004534	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283004535	putative active site [active]
223283004536	heme pocket [chemical binding]; other site
223283004537	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283004538	dimer interface [polypeptide binding]; other site
223283004539	phosphorylation site [posttranslational modification]
223283004540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283004541	ATP binding site [chemical binding]; other site
223283004542	Mg2+ binding site [ion binding]; other site
223283004543	G-X-G motif; other site
223283004544	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283004545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283004546	active site
223283004547	phosphorylation site [posttranslational modification]
223283004548	intermolecular recognition site; other site
223283004549	dimerization interface [polypeptide binding]; other site
223283004550	Protein of unknown function (DUF533); Region: DUF533; pfam04391
223283004551	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
223283004552	putative metal binding site [ion binding]; other site
223283004553	Leucine rich repeat; Region: LRR_8; pfam13855
223283004554	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283004555	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
223283004556	dimerization interface [polypeptide binding]; other site
223283004557	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283004558	dimer interface [polypeptide binding]; other site
223283004559	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
223283004560	putative CheW interface [polypeptide binding]; other site
223283004561	CheW-like domain; Region: CheW; pfam01584
223283004562	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
223283004563	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
223283004564	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
223283004565	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
223283004566	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
223283004567	putative binding surface; other site
223283004568	active site
223283004569	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
223283004570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283004571	ATP binding site [chemical binding]; other site
223283004572	Mg2+ binding site [ion binding]; other site
223283004573	G-X-G motif; other site
223283004574	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
223283004575	Response regulator receiver domain; Region: Response_reg; pfam00072
223283004576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283004577	active site
223283004578	phosphorylation site [posttranslational modification]
223283004579	intermolecular recognition site; other site
223283004580	dimerization interface [polypeptide binding]; other site
223283004581	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
223283004582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283004583	active site
223283004584	phosphorylation site [posttranslational modification]
223283004585	intermolecular recognition site; other site
223283004586	CheB methylesterase; Region: CheB_methylest; pfam01339
223283004587	Response regulator receiver domain; Region: Response_reg; pfam00072
223283004588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283004589	active site
223283004590	phosphorylation site [posttranslational modification]
223283004591	intermolecular recognition site; other site
223283004592	dimerization interface [polypeptide binding]; other site
223283004593	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283004594	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283004595	metal binding site [ion binding]; metal-binding site
223283004596	active site
223283004597	I-site; other site
223283004598	peptide chain release factor 2; Provisional; Region: PRK08787
223283004599	This domain is found in peptide chain release factors; Region: PCRF; smart00937
223283004600	RF-1 domain; Region: RF-1; pfam00472
223283004601	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
223283004602	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
223283004603	dimer interface [polypeptide binding]; other site
223283004604	putative anticodon binding site; other site
223283004605	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
223283004606	motif 1; other site
223283004607	active site
223283004608	motif 2; other site
223283004609	motif 3; other site
223283004610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
223283004611	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
223283004612	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
223283004613	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
223283004614	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
223283004615	CHASE3 domain; Region: CHASE3; cl05000
223283004616	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
223283004617	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
223283004618	ligand binding site [chemical binding]; other site
223283004619	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
223283004620	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
223283004621	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
223283004622	adenylate kinase; Reviewed; Region: adk; PRK00279
223283004623	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
223283004624	AMP-binding site [chemical binding]; other site
223283004625	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
223283004626	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
223283004627	Glycoprotease family; Region: Peptidase_M22; pfam00814
223283004628	Protein of unknown function DUF72; Region: DUF72; cl00777
223283004629	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
223283004630	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
223283004631	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
223283004632	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
223283004633	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
223283004634	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
223283004635	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
223283004636	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
223283004637	putative acyl-acceptor binding pocket; other site
223283004638	Putative zinc-finger of transcription factor IIIC complex; Region: zf-TFIIIC; pfam12660
223283004639	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
223283004640	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283004641	S-adenosylmethionine binding site [chemical binding]; other site
223283004642	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
223283004643	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
223283004644	metal binding site [ion binding]; metal-binding site
223283004645	dimer interface [polypeptide binding]; other site
223283004646	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
223283004647	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
223283004648	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
223283004649	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
223283004650	active site
223283004651	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
223283004652	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
223283004653	putative ATP binding site [chemical binding]; other site
223283004654	putative substrate interface [chemical binding]; other site
223283004655	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
223283004656	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
223283004657	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
223283004658	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283004659	catalytic residue [active]
223283004660	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
223283004661	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
223283004662	putative trimer interface [polypeptide binding]; other site
223283004663	putative CoA binding site [chemical binding]; other site
223283004664	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
223283004665	ArsC family; Region: ArsC; pfam03960
223283004666	putative catalytic residues [active]
223283004667	Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327
223283004668	active site
223283004669	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
223283004670	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283004671	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283004672	homodimer interface [polypeptide binding]; other site
223283004673	catalytic residue [active]
223283004674	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
223283004675	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
223283004676	metal binding triad; other site
223283004677	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
223283004678	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
223283004679	Zn2+ binding site [ion binding]; other site
223283004680	Mg2+ binding site [ion binding]; other site
223283004681	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
223283004682	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
223283004683	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
223283004684	active site
223283004685	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
223283004686	rRNA interaction site [nucleotide binding]; other site
223283004687	S8 interaction site; other site
223283004688	putative laminin-1 binding site; other site
223283004689	elongation factor Ts; Provisional; Region: tsf; PRK09377
223283004690	UBA/TS-N domain; Region: UBA; pfam00627
223283004691	Elongation factor TS; Region: EF_TS; pfam00889
223283004692	Elongation factor TS; Region: EF_TS; pfam00889
223283004693	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
223283004694	putative nucleotide binding site [chemical binding]; other site
223283004695	uridine monophosphate binding site [chemical binding]; other site
223283004696	homohexameric interface [polypeptide binding]; other site
223283004697	ribosome recycling factor; Reviewed; Region: frr; PRK00083
223283004698	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
223283004699	hinge region; other site
223283004700	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
223283004701	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
223283004702	catalytic residue [active]
223283004703	putative FPP diphosphate  binding site; other site
223283004704	putative FPP binding hydrophobic cleft; other site
223283004705	dimer interface [polypeptide binding]; other site
223283004706	putative IPP diphosphate binding site; other site
223283004707	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
223283004708	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
223283004709	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
223283004710	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
223283004711	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
223283004712	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
223283004713	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
223283004714	zinc metallopeptidase RseP; Provisional; Region: PRK10779
223283004715	active site
223283004716	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
223283004717	protein binding site [polypeptide binding]; other site
223283004718	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
223283004719	protein binding site [polypeptide binding]; other site
223283004720	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
223283004721	putative substrate binding region [chemical binding]; other site
223283004722	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
223283004723	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
223283004724	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
223283004725	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
223283004726	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
223283004727	Surface antigen; Region: Bac_surface_Ag; pfam01103
223283004728	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
223283004729	periplasmic chaperone; Provisional; Region: PRK10780
223283004730	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
223283004731	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
223283004732	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
223283004733	trimer interface [polypeptide binding]; other site
223283004734	active site
223283004735	UDP-GlcNAc binding site [chemical binding]; other site
223283004736	lipid binding site [chemical binding]; lipid-binding site
223283004737	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
223283004738	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
223283004739	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
223283004740	active site
223283004741	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
223283004742	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
223283004743	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
223283004744	RNA/DNA hybrid binding site [nucleotide binding]; other site
223283004745	active site
223283004746	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
223283004747	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
223283004748	putative active site [active]
223283004749	putative PHP Thumb interface [polypeptide binding]; other site
223283004750	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
223283004751	generic binding surface II; other site
223283004752	generic binding surface I; other site
223283004753	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
223283004754	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
223283004755	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
223283004756	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
223283004757	Ligand Binding Site [chemical binding]; other site
223283004758	TilS substrate binding domain; Region: TilS; pfam09179
223283004759	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
223283004760	CTP synthetase; Validated; Region: pyrG; PRK05380
223283004761	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
223283004762	Catalytic site [active]
223283004763	active site
223283004764	UTP binding site [chemical binding]; other site
223283004765	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
223283004766	active site
223283004767	putative oxyanion hole; other site
223283004768	catalytic triad [active]
223283004769	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
223283004770	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
223283004771	enolase; Provisional; Region: eno; PRK00077
223283004772	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
223283004773	dimer interface [polypeptide binding]; other site
223283004774	metal binding site [ion binding]; metal-binding site
223283004775	substrate binding pocket [chemical binding]; other site
223283004776	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
223283004777	Septum formation initiator; Region: DivIC; cl17659
223283004778	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
223283004779	substrate binding site; other site
223283004780	dimer interface; other site
223283004781	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283004782	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283004783	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
223283004784	putative effector binding pocket; other site
223283004785	putative dimerization interface [polypeptide binding]; other site
223283004786	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
223283004787	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
223283004788	substrate binding site [chemical binding]; other site
223283004789	catalytic Zn binding site [ion binding]; other site
223283004790	NAD binding site [chemical binding]; other site
223283004791	structural Zn binding site [ion binding]; other site
223283004792	dimer interface [polypeptide binding]; other site
223283004793	S-formylglutathione hydrolase; Region: PLN02442
223283004794	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
223283004795	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
223283004796	homotrimer interaction site [polypeptide binding]; other site
223283004797	zinc binding site [ion binding]; other site
223283004798	CDP-binding sites; other site
223283004799	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
223283004800	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
223283004801	Permutation of conserved domain; other site
223283004802	active site
223283004803	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
223283004804	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
223283004805	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
223283004806	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283004807	S-adenosylmethionine binding site [chemical binding]; other site
223283004808	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
223283004809	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
223283004810	Peptidase family M23; Region: Peptidase_M23; pfam01551
223283004811	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
223283004812	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
223283004813	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283004814	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
223283004815	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283004816	DNA binding residues [nucleotide binding]
223283004817	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283004818	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283004819	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283004820	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
223283004821	Mechanosensitive ion channel; Region: MS_channel; pfam00924
223283004822	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
223283004823	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283004824	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283004825	dimerization interface [polypeptide binding]; other site
223283004826	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283004827	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283004828	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
223283004829	putative effector binding pocket; other site
223283004830	putative dimerization interface [polypeptide binding]; other site
223283004831	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
223283004832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283004833	putative substrate translocation pore; other site
223283004834	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
223283004835	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
223283004836	Uncharacterized conserved protein [Function unknown]; Region: COG4925
223283004837	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
223283004838	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
223283004839	putative NAD(P) binding site [chemical binding]; other site
223283004840	active site
223283004841	Predicted transcriptional regulator [Transcription]; Region: COG2378
223283004842	HTH domain; Region: HTH_11; pfam08279
223283004843	WYL domain; Region: WYL; cl14852
223283004844	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
223283004845	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
223283004846	putative NAD(P) binding site [chemical binding]; other site
223283004847	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283004848	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283004849	substrate binding pocket [chemical binding]; other site
223283004850	membrane-bound complex binding site; other site
223283004851	hinge residues; other site
223283004852	helicase 45; Provisional; Region: PTZ00424
223283004853	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
223283004854	ATP binding site [chemical binding]; other site
223283004855	Mg++ binding site [ion binding]; other site
223283004856	motif III; other site
223283004857	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283004858	nucleotide binding region [chemical binding]; other site
223283004859	ATP-binding site [chemical binding]; other site
223283004860	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
223283004861	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
223283004862	S1 domain; Region: S1_2; pfam13509
223283004863	S1 domain; Region: S1_2; pfam13509
223283004864	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
223283004865	CsbD-like; Region: CsbD; pfam05532
223283004866	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
223283004867	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
223283004868	active site
223283004869	catalytic residues [active]
223283004870	metal binding site [ion binding]; metal-binding site
223283004871	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
223283004872	Coenzyme A binding pocket [chemical binding]; other site
223283004873	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
223283004874	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
223283004875	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
223283004876	nucleoside/Zn binding site; other site
223283004877	dimer interface [polypeptide binding]; other site
223283004878	catalytic motif [active]
223283004879	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
223283004880	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283004881	PAS domain; Region: PAS_9; pfam13426
223283004882	putative active site [active]
223283004883	heme pocket [chemical binding]; other site
223283004884	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283004885	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283004886	dimer interface [polypeptide binding]; other site
223283004887	phosphorylation site [posttranslational modification]
223283004888	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283004889	ATP binding site [chemical binding]; other site
223283004890	Mg2+ binding site [ion binding]; other site
223283004891	G-X-G motif; other site
223283004892	GAF domain; Region: GAF; pfam01590
223283004893	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283004894	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283004895	dimer interface [polypeptide binding]; other site
223283004896	phosphorylation site [posttranslational modification]
223283004897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283004898	ATP binding site [chemical binding]; other site
223283004899	Mg2+ binding site [ion binding]; other site
223283004900	G-X-G motif; other site
223283004901	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
223283004902	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
223283004903	Predicted membrane protein [Function unknown]; Region: COG3212
223283004904	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
223283004905	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283004906	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283004907	N-terminal plug; other site
223283004908	ligand-binding site [chemical binding]; other site
223283004909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283004910	metabolite-proton symporter; Region: 2A0106; TIGR00883
223283004911	putative substrate translocation pore; other site
223283004912	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283004913	DNA binding residues [nucleotide binding]
223283004914	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283004915	dimerization interface [polypeptide binding]; other site
223283004916	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
223283004917	MASE2 domain; Region: MASE2; pfam05230
223283004918	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283004919	metal binding site [ion binding]; metal-binding site
223283004920	active site
223283004921	I-site; other site
223283004922	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283004923	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283004924	putative substrate translocation pore; other site
223283004925	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283004926	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283004927	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
223283004928	putative effector binding pocket; other site
223283004929	putative dimerization interface [polypeptide binding]; other site
223283004930	hypothetical protein; Provisional; Region: PRK11615
223283004931	VacJ like lipoprotein; Region: VacJ; cl01073
223283004932	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
223283004933	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
223283004934	Predicted membrane protein [Function unknown]; Region: COG3162
223283004935	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
223283004936	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
223283004937	Na binding site [ion binding]; other site
223283004938	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
223283004939	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
223283004940	short chain dehydrogenase; Provisional; Region: PRK05650
223283004941	classical (c) SDRs; Region: SDR_c; cd05233
223283004942	NAD(P) binding site [chemical binding]; other site
223283004943	active site
223283004944	hypothetical protein; Provisional; Region: PRK02237
223283004945	carbon storage regulator; Provisional; Region: PRK01712
223283004946	hypothetical protein; Provisional; Region: PRK00304
223283004947	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
223283004948	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
223283004949	putative oligomer interface [polypeptide binding]; other site
223283004950	putative active site [active]
223283004951	metal binding site [ion binding]; metal-binding site
223283004952	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
223283004953	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283004954	Coenzyme A binding pocket [chemical binding]; other site
223283004955	ATP-grasp domain; Region: ATP-grasp_4; cl17255
223283004956	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
223283004957	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
223283004958	active site
223283004959	dimer interface [polypeptide binding]; other site
223283004960	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
223283004961	Ligand Binding Site [chemical binding]; other site
223283004962	Molecular Tunnel; other site
223283004963	YcfA-like protein; Region: YcfA; pfam07927
223283004964	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
223283004965	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
223283004966	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
223283004967	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
223283004968	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
223283004969	Walker A/P-loop; other site
223283004970	ATP binding site [chemical binding]; other site
223283004971	Q-loop/lid; other site
223283004972	ABC transporter signature motif; other site
223283004973	Walker B; other site
223283004974	D-loop; other site
223283004975	H-loop/switch region; other site
223283004976	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
223283004977	Uncharacterized conserved protein [Function unknown]; Region: COG4121
223283004978	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
223283004979	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
223283004980	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
223283004981	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
223283004982	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
223283004983	yecA family protein; Region: ygfB_yecA; TIGR02292
223283004984	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
223283004985	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283004986	ATP binding site [chemical binding]; other site
223283004987	putative Mg++ binding site [ion binding]; other site
223283004988	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283004989	nucleotide binding region [chemical binding]; other site
223283004990	ATP-binding site [chemical binding]; other site
223283004991	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
223283004992	HRDC domain; Region: HRDC; pfam00570
223283004993	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
223283004994	MarR family; Region: MarR_2; pfam12802
223283004995	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
223283004996	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
223283004997	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283004998	PAS domain; Region: PAS_9; pfam13426
223283004999	putative active site [active]
223283005000	heme pocket [chemical binding]; other site
223283005001	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283005002	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283005003	dimer interface [polypeptide binding]; other site
223283005004	putative CheW interface [polypeptide binding]; other site
223283005005	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
223283005006	catalytic triad [active]
223283005007	putative active site [active]
223283005008	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
223283005009	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
223283005010	Autotransporter beta-domain; Region: Autotransporter; pfam03797
223283005011	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
223283005012	catalytic triad [active]
223283005013	putative active site [active]
223283005014	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
223283005015	Autotransporter beta-domain; Region: Autotransporter; pfam03797
223283005016	BRO family, N-terminal domain; Region: Bro-N; smart01040
223283005017	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
223283005018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
223283005019	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
223283005020	Uncharacterized conserved protein [Function unknown]; Region: COG1479
223283005021	Protein of unknown function DUF262; Region: DUF262; pfam03235
223283005022	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
223283005023	transposase/IS protein; Provisional; Region: PRK09183
223283005024	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283005025	Walker A motif; other site
223283005026	ATP binding site [chemical binding]; other site
223283005027	Walker B motif; other site
223283005028	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283005029	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283005030	DNA-binding interface [nucleotide binding]; DNA binding site
223283005031	Integrase core domain; Region: rve; pfam00665
223283005032	Integrase core domain; Region: rve_3; cl15866
223283005033	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283005034	ATP binding site [chemical binding]; other site
223283005035	putative Mg++ binding site [ion binding]; other site
223283005036	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
223283005037	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283005038	nucleotide binding region [chemical binding]; other site
223283005039	ATP-binding site [chemical binding]; other site
223283005040	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
223283005041	dimer interface [polypeptide binding]; other site
223283005042	putative radical transfer pathway; other site
223283005043	diiron center [ion binding]; other site
223283005044	tyrosyl radical; other site
223283005045	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
223283005046	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283005047	Coenzyme A binding pocket [chemical binding]; other site
223283005048	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
223283005049	BON domain; Region: BON; pfam04972
223283005050	BON domain; Region: BON; pfam04972
223283005051	BON domain; Region: BON; pfam04972
223283005052	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
223283005053	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
223283005054	ligand binding site [chemical binding]; other site
223283005055	flexible hinge region; other site
223283005056	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
223283005057	putative switch regulator; other site
223283005058	non-specific DNA interactions [nucleotide binding]; other site
223283005059	DNA binding site [nucleotide binding]
223283005060	sequence specific DNA binding site [nucleotide binding]; other site
223283005061	putative cAMP binding site [chemical binding]; other site
223283005062	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
223283005063	Ligand Binding Site [chemical binding]; other site
223283005064	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
223283005065	Ligand Binding Site [chemical binding]; other site
223283005066	Acetokinase family; Region: Acetate_kinase; cl17229
223283005067	propionate/acetate kinase; Provisional; Region: PRK12379
223283005068	putative phosphoketolase; Provisional; Region: PRK05261
223283005069	XFP N-terminal domain; Region: XFP_N; pfam09364
223283005070	XFP C-terminal domain; Region: XFP_C; pfam09363
223283005071	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
223283005072	ATP cone domain; Region: ATP-cone; pfam03477
223283005073	ATP cone domain; Region: ATP-cone; pfam03477
223283005074	Class I ribonucleotide reductase; Region: RNR_I; cd01679
223283005075	active site
223283005076	dimer interface [polypeptide binding]; other site
223283005077	catalytic residues [active]
223283005078	effector binding site; other site
223283005079	R2 peptide binding site; other site
223283005080	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
223283005081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283005082	active site
223283005083	phosphorylation site [posttranslational modification]
223283005084	intermolecular recognition site; other site
223283005085	dimerization interface [polypeptide binding]; other site
223283005086	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283005087	DNA binding site [nucleotide binding]
223283005088	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283005089	dimerization interface [polypeptide binding]; other site
223283005090	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283005091	dimer interface [polypeptide binding]; other site
223283005092	phosphorylation site [posttranslational modification]
223283005093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283005094	ATP binding site [chemical binding]; other site
223283005095	Mg2+ binding site [ion binding]; other site
223283005096	G-X-G motif; other site
223283005097	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
223283005098	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
223283005099	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
223283005100	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
223283005101	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
223283005102	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
223283005103	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
223283005104	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
223283005105	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
223283005106	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283005107	active site
223283005108	phosphorylation site [posttranslational modification]
223283005109	intermolecular recognition site; other site
223283005110	dimerization interface [polypeptide binding]; other site
223283005111	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283005112	DNA binding site [nucleotide binding]
223283005113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
223283005114	dimer interface [polypeptide binding]; other site
223283005115	phosphorylation site [posttranslational modification]
223283005116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283005117	ATP binding site [chemical binding]; other site
223283005118	Mg2+ binding site [ion binding]; other site
223283005119	G-X-G motif; other site
223283005120	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
223283005121	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
223283005122	hypothetical protein; Provisional; Region: PRK04860
223283005123	SprT homologues; Region: SprT; cl01182
223283005124	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
223283005125	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
223283005126	Ligand Binding Site [chemical binding]; other site
223283005127	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
223283005128	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
223283005129	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
223283005130	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
223283005131	ArsC family; Region: ArsC; pfam03960
223283005132	catalytic residues [active]
223283005133	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
223283005134	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
223283005135	catalytic residues [active]
223283005136	META domain; Region: META; pfam03724
223283005137	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
223283005138	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283005139	dimerization interface [polypeptide binding]; other site
223283005140	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283005141	dimer interface [polypeptide binding]; other site
223283005142	phosphorylation site [posttranslational modification]
223283005143	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283005144	ATP binding site [chemical binding]; other site
223283005145	Mg2+ binding site [ion binding]; other site
223283005146	G-X-G motif; other site
223283005147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283005148	active site
223283005149	phosphorylation site [posttranslational modification]
223283005150	intermolecular recognition site; other site
223283005151	dimerization interface [polypeptide binding]; other site
223283005152	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
223283005153	putative binding surface; other site
223283005154	active site
223283005155	cysteine synthase B; Region: cysM; TIGR01138
223283005156	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
223283005157	dimer interface [polypeptide binding]; other site
223283005158	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283005159	catalytic residue [active]
223283005160	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
223283005161	TRAM domain; Region: TRAM; pfam01938
223283005162	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283005163	S-adenosylmethionine binding site [chemical binding]; other site
223283005164	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
223283005165	HD domain; Region: HD_4; pfam13328
223283005166	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
223283005167	synthetase active site [active]
223283005168	NTP binding site [chemical binding]; other site
223283005169	metal binding site [ion binding]; metal-binding site
223283005170	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
223283005171	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
223283005172	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
223283005173	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
223283005174	homodimer interface [polypeptide binding]; other site
223283005175	metal binding site [ion binding]; metal-binding site
223283005176	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
223283005177	homodimer interface [polypeptide binding]; other site
223283005178	active site
223283005179	putative chemical substrate binding site [chemical binding]; other site
223283005180	metal binding site [ion binding]; metal-binding site
223283005181	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
223283005182	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
223283005183	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
223283005184	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
223283005185	active site
223283005186	substrate binding site [chemical binding]; other site
223283005187	cosubstrate binding site; other site
223283005188	catalytic site [active]
223283005189	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
223283005190	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
223283005191	dimerization interface [polypeptide binding]; other site
223283005192	putative ATP binding site [chemical binding]; other site
223283005193	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249
223283005194	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
223283005195	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
223283005196	Domain of unknown function DUF20; Region: UPF0118; pfam01594
223283005197	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
223283005198	DNA replication initiation factor; Validated; Region: PRK05642
223283005199	Walker A motif; other site
223283005200	ATP binding site [chemical binding]; other site
223283005201	Walker B motif; other site
223283005202	arginine finger; other site
223283005203	NAD-dependent deacetylase; Provisional; Region: PRK00481
223283005204	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
223283005205	NAD+ binding site [chemical binding]; other site
223283005206	substrate binding site [chemical binding]; other site
223283005207	Zn binding site [ion binding]; other site
223283005208	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
223283005209	NlpC/P60 family; Region: NLPC_P60; pfam00877
223283005210	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
223283005211	NlpC/P60 family; Region: NLPC_P60; pfam00877
223283005212	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
223283005213	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
223283005214	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
223283005215	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
223283005216	Walker A motif; other site
223283005217	homodimer interface [polypeptide binding]; other site
223283005218	ATP binding site [chemical binding]; other site
223283005219	hydroxycobalamin binding site [chemical binding]; other site
223283005220	Walker B motif; other site
223283005221	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
223283005222	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
223283005223	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
223283005224	catalytic triad [active]
223283005225	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
223283005226	putative FMN binding site [chemical binding]; other site
223283005227	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
223283005228	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
223283005229	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283005230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283005231	homodimer interface [polypeptide binding]; other site
223283005232	catalytic residue [active]
223283005233	cobyric acid synthase; Provisional; Region: PRK00784
223283005234	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
223283005235	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
223283005236	catalytic triad [active]
223283005237	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
223283005238	homotrimer interface [polypeptide binding]; other site
223283005239	Walker A motif; other site
223283005240	GTP binding site [chemical binding]; other site
223283005241	Walker B motif; other site
223283005242	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
223283005243	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
223283005244	putative dimer interface [polypeptide binding]; other site
223283005245	active site pocket [active]
223283005246	putative cataytic base [active]
223283005247	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
223283005248	catalytic core [active]
223283005249	cobalamin synthase; Reviewed; Region: cobS; PRK00235
223283005250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283005251	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283005252	putative substrate translocation pore; other site
223283005253	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
223283005254	catalytic residues [active]
223283005255	dimer interface [polypeptide binding]; other site
223283005256	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
223283005257	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
223283005258	RmuC family; Region: RmuC; pfam02646
223283005259	DTW domain; Region: DTW; cl01221
223283005260	EamA-like transporter family; Region: EamA; pfam00892
223283005261	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
223283005262	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
223283005263	fumarate hydratase; Provisional; Region: PRK12425
223283005264	Class II fumarases; Region: Fumarase_classII; cd01362
223283005265	active site
223283005266	tetramer interface [polypeptide binding]; other site
223283005267	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
223283005268	BolA-like protein; Region: BolA; cl00386
223283005269	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
223283005270	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
223283005271	active site residue [active]
223283005272	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
223283005273	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
223283005274	catalytic residues [active]
223283005275	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
223283005276	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
223283005277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283005278	Walker A/P-loop; other site
223283005279	ATP binding site [chemical binding]; other site
223283005280	Q-loop/lid; other site
223283005281	ABC transporter signature motif; other site
223283005282	Walker B; other site
223283005283	D-loop; other site
223283005284	H-loop/switch region; other site
223283005285	PAS domain S-box; Region: sensory_box; TIGR00229
223283005286	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283005287	putative active site [active]
223283005288	heme pocket [chemical binding]; other site
223283005289	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283005290	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283005291	metal binding site [ion binding]; metal-binding site
223283005292	active site
223283005293	I-site; other site
223283005294	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283005295	Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424
223283005296	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283005297	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283005298	metal binding site [ion binding]; metal-binding site
223283005299	active site
223283005300	I-site; other site
223283005301	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
223283005302	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
223283005303	NADP binding site [chemical binding]; other site
223283005304	homodimer interface [polypeptide binding]; other site
223283005305	active site
223283005306	phosphoglycolate phosphatase; Provisional; Region: PRK13222
223283005307	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283005308	motif II; other site
223283005309	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
223283005310	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283005311	S-adenosylmethionine binding site [chemical binding]; other site
223283005312	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
223283005313	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
223283005314	active site
223283005315	putative substrate binding pocket [chemical binding]; other site
223283005316	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
223283005317	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
223283005318	DNA gyrase subunit A; Validated; Region: PRK05560
223283005319	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
223283005320	CAP-like domain; other site
223283005321	active site
223283005322	primary dimer interface [polypeptide binding]; other site
223283005323	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
223283005324	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
223283005325	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
223283005326	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
223283005327	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
223283005328	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
223283005329	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
223283005330	homodimer interface [polypeptide binding]; other site
223283005331	substrate-cofactor binding pocket; other site
223283005332	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283005333	catalytic residue [active]
223283005334	Chorismate mutase type II; Region: CM_2; cl00693
223283005335	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
223283005336	Prephenate dehydratase; Region: PDT; pfam00800
223283005337	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
223283005338	putative L-Phe binding site [chemical binding]; other site
223283005339	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
223283005340	prephenate dehydrogenase; Validated; Region: PRK08507
223283005341	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
223283005342	putative active site [active]
223283005343	cytidylate kinase; Provisional; Region: cmk; PRK00023
223283005344	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
223283005345	CMP-binding site; other site
223283005346	The sites determining sugar specificity; other site
223283005347	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
223283005348	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
223283005349	RNA binding site [nucleotide binding]; other site
223283005350	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
223283005351	RNA binding site [nucleotide binding]; other site
223283005352	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
223283005353	RNA binding site [nucleotide binding]; other site
223283005354	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
223283005355	RNA binding site [nucleotide binding]; other site
223283005356	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
223283005357	RNA binding site [nucleotide binding]; other site
223283005358	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
223283005359	RNA binding site [nucleotide binding]; other site
223283005360	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
223283005361	IHF dimer interface [polypeptide binding]; other site
223283005362	IHF - DNA interface [nucleotide binding]; other site
223283005363	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
223283005364	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
223283005365	Beta-Casp domain; Region: Beta-Casp; smart01027
223283005366	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
223283005367	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
223283005368	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283005369	NAD(P) binding site [chemical binding]; other site
223283005370	active site
223283005371	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
223283005372	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
223283005373	Mg++ binding site [ion binding]; other site
223283005374	putative catalytic motif [active]
223283005375	putative substrate binding site [chemical binding]; other site
223283005376	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
223283005377	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
223283005378	NAD(P) binding site [chemical binding]; other site
223283005379	homodimer interface [polypeptide binding]; other site
223283005380	substrate binding site [chemical binding]; other site
223283005381	active site
223283005382	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
223283005383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283005384	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283005385	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
223283005386	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
223283005387	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
223283005388	catalytic residues [active]
223283005389	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
223283005390	serine transporter; Region: stp; TIGR00814
223283005391	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
223283005392	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
223283005393	conserved hypothetical protein, PP_1857 family; Region: efp_adjacent_2; TIGR03837
223283005394	elongation factor P; Validated; Region: PRK00529
223283005395	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
223283005396	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
223283005397	RNA binding site [nucleotide binding]; other site
223283005398	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
223283005399	RNA binding site [nucleotide binding]; other site
223283005400	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
223283005401	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
223283005402	substrate binding pocket [chemical binding]; other site
223283005403	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
223283005404	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
223283005405	Transcriptional regulators [Transcription]; Region: MarR; COG1846
223283005406	MarR family; Region: MarR; pfam01047
223283005407	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
223283005408	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283005409	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283005410	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283005411	dimerization interface [polypeptide binding]; other site
223283005412	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
223283005413	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
223283005414	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283005415	helicase 45; Provisional; Region: PTZ00424
223283005416	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
223283005417	ATP binding site [chemical binding]; other site
223283005418	Mg++ binding site [ion binding]; other site
223283005419	motif III; other site
223283005420	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283005421	nucleotide binding region [chemical binding]; other site
223283005422	ATP-binding site [chemical binding]; other site
223283005423	DbpA RNA binding domain; Region: DbpA; pfam03880
223283005424	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
223283005425	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
223283005426	putative active site [active]
223283005427	metal binding site [ion binding]; metal-binding site
223283005428	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
223283005429	heat shock protein HtpX; Provisional; Region: PRK05457
223283005430	aminotransferase AlaT; Validated; Region: PRK09265
223283005431	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283005432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283005433	homodimer interface [polypeptide binding]; other site
223283005434	catalytic residue [active]
223283005435	methionine sulfoxide reductase B; Provisional; Region: PRK00222
223283005436	SelR domain; Region: SelR; pfam01641
223283005437	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
223283005438	catalytic residues [active]
223283005439	dimer interface [polypeptide binding]; other site
223283005440	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283005441	dimer interface [polypeptide binding]; other site
223283005442	phosphorylation site [posttranslational modification]
223283005443	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283005444	ATP binding site [chemical binding]; other site
223283005445	Mg2+ binding site [ion binding]; other site
223283005446	G-X-G motif; other site
223283005447	Response regulator receiver domain; Region: Response_reg; pfam00072
223283005448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283005449	active site
223283005450	phosphorylation site [posttranslational modification]
223283005451	intermolecular recognition site; other site
223283005452	dimerization interface [polypeptide binding]; other site
223283005453	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
223283005454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283005455	Walker A motif; other site
223283005456	ATP binding site [chemical binding]; other site
223283005457	Walker B motif; other site
223283005458	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
223283005459	GAF domain; Region: GAF_2; pfam13185
223283005460	Pirin-related protein [General function prediction only]; Region: COG1741
223283005461	Pirin; Region: Pirin; pfam02678
223283005462	LysR family transcriptional regulator; Provisional; Region: PRK14997
223283005463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283005464	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
223283005465	putative effector binding pocket; other site
223283005466	dimerization interface [polypeptide binding]; other site
223283005467	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
223283005468	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283005469	substrate binding pocket [chemical binding]; other site
223283005470	membrane-bound complex binding site; other site
223283005471	hinge residues; other site
223283005472	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
223283005473	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
223283005474	molybdopterin cofactor binding site [chemical binding]; other site
223283005475	substrate binding site [chemical binding]; other site
223283005476	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
223283005477	molybdopterin cofactor binding site; other site
223283005478	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
223283005479	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
223283005480	active site
223283005481	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
223283005482	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283005483	substrate binding pocket [chemical binding]; other site
223283005484	membrane-bound complex binding site; other site
223283005485	Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532
223283005486	active site residue [active]
223283005487	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
223283005488	active site residue [active]
223283005489	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
223283005490	active site residue [active]
223283005491	Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535
223283005492	active site residue [active]
223283005493	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
223283005494	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283005495	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283005496	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
223283005497	dimerization interface [polypeptide binding]; other site
223283005498	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
223283005499	active site
223283005500	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
223283005501	dimer interface [polypeptide binding]; other site
223283005502	non-prolyl cis peptide bond; other site
223283005503	insertion regions; other site
223283005504	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
223283005505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283005506	dimer interface [polypeptide binding]; other site
223283005507	conserved gate region; other site
223283005508	putative PBP binding loops; other site
223283005509	ABC-ATPase subunit interface; other site
223283005510	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
223283005511	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
223283005512	Walker A/P-loop; other site
223283005513	ATP binding site [chemical binding]; other site
223283005514	Q-loop/lid; other site
223283005515	ABC transporter signature motif; other site
223283005516	Walker B; other site
223283005517	D-loop; other site
223283005518	H-loop/switch region; other site
223283005519	Rdx family; Region: Rdx; cl01407
223283005520	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
223283005521	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
223283005522	putative active site [active]
223283005523	putative metal binding site [ion binding]; other site
223283005524	Protein of unknown function (DUF962); Region: DUF962; pfam06127
223283005525	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
223283005526	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
223283005527	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
223283005528	putative FMN binding site [chemical binding]; other site
223283005529	two-component sensor protein; Provisional; Region: cpxA; PRK09470
223283005530	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283005531	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
223283005532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283005533	ATP binding site [chemical binding]; other site
223283005534	G-X-G motif; other site
223283005535	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
223283005536	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
223283005537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283005538	active site
223283005539	phosphorylation site [posttranslational modification]
223283005540	intermolecular recognition site; other site
223283005541	dimerization interface [polypeptide binding]; other site
223283005542	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283005543	DNA binding site [nucleotide binding]
223283005544	SH3 domain-containing protein; Provisional; Region: PRK10884
223283005545	YciI-like protein; Reviewed; Region: PRK11370
223283005546	intracellular septation protein A; Reviewed; Region: PRK00259
223283005547	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
223283005548	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
223283005549	active site
223283005550	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
223283005551	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
223283005552	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
223283005553	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
223283005554	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
223283005555	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
223283005556	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
223283005557	RNA binding surface [nucleotide binding]; other site
223283005558	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
223283005559	probable active site [active]
223283005560	aromatic amino acid transporter; Provisional; Region: PRK10238
223283005561	hypothetical protein; Provisional; Region: PRK09256
223283005562	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
223283005563	major facilitator superfamily transporter; Provisional; Region: PRK05122
223283005564	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
223283005565	aromatic arch; other site
223283005566	DCoH dimer interaction site [polypeptide binding]; other site
223283005567	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
223283005568	DCoH tetramer interaction site [polypeptide binding]; other site
223283005569	substrate binding site [chemical binding]; other site
223283005570	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
223283005571	cofactor binding site; other site
223283005572	metal binding site [ion binding]; metal-binding site
223283005573	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
223283005574	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
223283005575	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283005576	Walker A motif; other site
223283005577	ATP binding site [chemical binding]; other site
223283005578	Walker B motif; other site
223283005579	arginine finger; other site
223283005580	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
223283005581	acetyl-CoA synthetase; Provisional; Region: PRK00174
223283005582	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
223283005583	active site
223283005584	CoA binding site [chemical binding]; other site
223283005585	acyl-activating enzyme (AAE) consensus motif; other site
223283005586	AMP binding site [chemical binding]; other site
223283005587	acetate binding site [chemical binding]; other site
223283005588	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
223283005589	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283005590	substrate binding pocket [chemical binding]; other site
223283005591	membrane-bound complex binding site; other site
223283005592	hinge residues; other site
223283005593	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283005594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283005595	dimer interface [polypeptide binding]; other site
223283005596	conserved gate region; other site
223283005597	putative PBP binding loops; other site
223283005598	ABC-ATPase subunit interface; other site
223283005599	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283005600	dimer interface [polypeptide binding]; other site
223283005601	conserved gate region; other site
223283005602	putative PBP binding loops; other site
223283005603	ABC-ATPase subunit interface; other site
223283005604	Predicted deacylase [General function prediction only]; Region: COG3608
223283005605	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
223283005606	active site
223283005607	Zn binding site [ion binding]; other site
223283005608	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
223283005609	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283005610	Walker A/P-loop; other site
223283005611	ATP binding site [chemical binding]; other site
223283005612	Q-loop/lid; other site
223283005613	ABC transporter signature motif; other site
223283005614	Walker B; other site
223283005615	D-loop; other site
223283005616	H-loop/switch region; other site
223283005617	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
223283005618	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
223283005619	conserved cys residue [active]
223283005620	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283005621	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283005622	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
223283005623	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283005624	inhibitor-cofactor binding pocket; inhibition site
223283005625	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283005626	catalytic residue [active]
223283005627	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
223283005628	arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245
223283005629	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
223283005630	arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244
223283005631	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
223283005632	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
223283005633	NAD(P) binding site [chemical binding]; other site
223283005634	catalytic residues [active]
223283005635	succinylarginine dihydrolase; Provisional; Region: PRK13281
223283005636	succinylglutamate desuccinylase; Provisional; Region: PRK05324
223283005637	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
223283005638	active site
223283005639	Zn binding site [ion binding]; other site
223283005640	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
223283005641	active site
223283005642	homopentamer interface [polypeptide binding]; other site
223283005643	dimer interface [polypeptide binding]; other site
223283005644	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
223283005645	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
223283005646	tetramer interface [polypeptide binding]; other site
223283005647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283005648	catalytic residue [active]
223283005649	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
223283005650	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
223283005651	motif 1; other site
223283005652	active site
223283005653	motif 2; other site
223283005654	motif 3; other site
223283005655	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
223283005656	DHHA1 domain; Region: DHHA1; pfam02272
223283005657	aspartate kinase; Reviewed; Region: PRK06635
223283005658	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
223283005659	putative nucleotide binding site [chemical binding]; other site
223283005660	putative catalytic residues [active]
223283005661	putative Mg ion binding site [ion binding]; other site
223283005662	putative aspartate binding site [chemical binding]; other site
223283005663	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
223283005664	putative allosteric regulatory site; other site
223283005665	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
223283005666	putative allosteric regulatory residue; other site
223283005667	carbon storage regulator; Provisional; Region: PRK01712
223283005668	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
223283005669	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
223283005670	MgtE intracellular N domain; Region: MgtE_N; smart00924
223283005671	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
223283005672	Divalent cation transporter; Region: MgtE; pfam01769
223283005673	Arc-like DNA binding domain; Region: Arc; pfam03869
223283005674	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
223283005675	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
223283005676	Mechanosensitive ion channel; Region: MS_channel; pfam00924
223283005677	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
223283005678	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
223283005679	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283005680	N-terminal plug; other site
223283005681	ligand-binding site [chemical binding]; other site
223283005682	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
223283005683	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
223283005684	conserved cys residue [active]
223283005685	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283005686	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283005687	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
223283005688	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
223283005689	conserved cys residue [active]
223283005690	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283005691	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
223283005692	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
223283005693	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
223283005694	Isochorismatase family; Region: Isochorismatase; pfam00857
223283005695	catalytic triad [active]
223283005696	conserved cis-peptide bond; other site
223283005697	Protein of unknown function, DUF393; Region: DUF393; pfam04134
223283005698	short chain dehydrogenase; Provisional; Region: PRK06179
223283005699	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
223283005700	NADP binding site [chemical binding]; other site
223283005701	active site
223283005702	steroid binding site; other site
223283005703	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
223283005704	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
223283005705	putative NAD(P) binding site [chemical binding]; other site
223283005706	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
223283005707	TAP-like protein; Region: Abhydrolase_4; pfam08386
223283005708	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
223283005709	classical (c) SDRs; Region: SDR_c; cd05233
223283005710	NAD(P) binding site [chemical binding]; other site
223283005711	active site
223283005712	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
223283005713	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
223283005714	FMN binding site [chemical binding]; other site
223283005715	active site
223283005716	substrate binding site [chemical binding]; other site
223283005717	catalytic residue [active]
223283005718	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283005719	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283005720	WHG domain; Region: WHG; pfam13305
223283005721	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
223283005722	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
223283005723	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
223283005724	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
223283005725	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283005726	putative active site [active]
223283005727	heme pocket [chemical binding]; other site
223283005728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283005729	putative active site [active]
223283005730	heme pocket [chemical binding]; other site
223283005731	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283005732	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283005733	dimer interface [polypeptide binding]; other site
223283005734	phosphorylation site [posttranslational modification]
223283005735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283005736	ATP binding site [chemical binding]; other site
223283005737	Mg2+ binding site [ion binding]; other site
223283005738	G-X-G motif; other site
223283005739	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283005740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283005741	active site
223283005742	phosphorylation site [posttranslational modification]
223283005743	intermolecular recognition site; other site
223283005744	dimerization interface [polypeptide binding]; other site
223283005745	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
223283005746	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
223283005747	Na binding site [ion binding]; other site
223283005748	putative substrate binding site [chemical binding]; other site
223283005749	Transcriptional regulators [Transcription]; Region: FadR; COG2186
223283005750	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283005751	DNA-binding site [nucleotide binding]; DNA binding site
223283005752	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
223283005753	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
223283005754	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
223283005755	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
223283005756	NAD binding site [chemical binding]; other site
223283005757	catalytic Zn binding site [ion binding]; other site
223283005758	structural Zn binding site [ion binding]; other site
223283005759	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283005760	Integrase core domain; Region: rve; pfam00665
223283005761	Integrase core domain; Region: rve_3; pfam13683
223283005762	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283005763	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283005764	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283005765	dimerization interface [polypeptide binding]; other site
223283005766	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
223283005767	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
223283005768	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
223283005769	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
223283005770	NAD(P) binding site [chemical binding]; other site
223283005771	catalytic residues [active]
223283005772	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
223283005773	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
223283005774	metal binding site [ion binding]; metal-binding site
223283005775	putative dimer interface [polypeptide binding]; other site
223283005776	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
223283005777	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283005778	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283005779	dimerization interface [polypeptide binding]; other site
223283005780	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
223283005781	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
223283005782	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
223283005783	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
223283005784	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
223283005785	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283005786	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
223283005787	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
223283005788	dimerization interface [polypeptide binding]; other site
223283005789	substrate binding pocket [chemical binding]; other site
223283005790	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
223283005791	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
223283005792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
223283005793	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
223283005794	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283005795	inhibitor-cofactor binding pocket; inhibition site
223283005796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283005797	catalytic residue [active]
223283005798	aldehyde dehydrogenase family 7 member; Region: PLN02315
223283005799	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
223283005800	tetrameric interface [polypeptide binding]; other site
223283005801	NAD binding site [chemical binding]; other site
223283005802	catalytic residues [active]
223283005803	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
223283005804	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
223283005805	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283005806	HAMP domain; Region: HAMP; pfam00672
223283005807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283005808	dimer interface [polypeptide binding]; other site
223283005809	phosphorylation site [posttranslational modification]
223283005810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283005811	ATP binding site [chemical binding]; other site
223283005812	Mg2+ binding site [ion binding]; other site
223283005813	G-X-G motif; other site
223283005814	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
223283005815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283005816	active site
223283005817	phosphorylation site [posttranslational modification]
223283005818	intermolecular recognition site; other site
223283005819	dimerization interface [polypeptide binding]; other site
223283005820	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283005821	DNA binding site [nucleotide binding]
223283005822	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
223283005823	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
223283005824	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
223283005825	BNR repeat-like domain; Region: BNR_2; pfam13088
223283005826	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
223283005827	Sulfatase; Region: Sulfatase; pfam00884
223283005828	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
223283005829	heme binding pocket [chemical binding]; other site
223283005830	heme ligand [chemical binding]; other site
223283005831	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
223283005832	GAF domain; Region: GAF; pfam01590
223283005833	Phytochrome region; Region: PHY; pfam00360
223283005834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283005835	dimer interface [polypeptide binding]; other site
223283005836	phosphorylation site [posttranslational modification]
223283005837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283005838	ATP binding site [chemical binding]; other site
223283005839	Mg2+ binding site [ion binding]; other site
223283005840	G-X-G motif; other site
223283005841	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
223283005842	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283005843	putative substrate translocation pore; other site
223283005844	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
223283005845	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
223283005846	Cupin domain; Region: Cupin_2; cl17218
223283005847	Helix-turn-helix domain; Region: HTH_18; pfam12833
223283005848	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283005849	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
223283005850	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
223283005851	SH3 domain-containing protein; Provisional; Region: PRK10884
223283005852	Bacterial SH3 domain; Region: SH3_3; pfam08239
223283005853	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
223283005854	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283005855	active site
223283005856	phosphorylation site [posttranslational modification]
223283005857	intermolecular recognition site; other site
223283005858	dimerization interface [polypeptide binding]; other site
223283005859	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283005860	binding surface
223283005861	TPR motif; other site
223283005862	TPR repeat; Region: TPR_11; pfam13414
223283005863	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283005864	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283005865	ATP binding site [chemical binding]; other site
223283005866	Mg2+ binding site [ion binding]; other site
223283005867	G-X-G motif; other site
223283005868	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
223283005869	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
223283005870	classical (c) SDRs; Region: SDR_c; cd05233
223283005871	NAD(P) binding site [chemical binding]; other site
223283005872	active site
223283005873	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
223283005874	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
223283005875	putative trimer interface [polypeptide binding]; other site
223283005876	putative CoA binding site [chemical binding]; other site
223283005877	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
223283005878	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
223283005879	dimer interface [polypeptide binding]; other site
223283005880	active site
223283005881	CoA binding pocket [chemical binding]; other site
223283005882	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283005883	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283005884	putative substrate translocation pore; other site
223283005885	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
223283005886	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
223283005887	active site
223283005888	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
223283005889	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
223283005890	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
223283005891	Probable Catalytic site; other site
223283005892	metal-binding site
223283005893	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
223283005894	Methyltransferase domain; Region: Methyltransf_23; pfam13489
223283005895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283005896	S-adenosylmethionine binding site [chemical binding]; other site
223283005897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
223283005898	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
223283005899	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
223283005900	inhibitor-cofactor binding pocket; inhibition site
223283005901	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283005902	catalytic residue [active]
223283005903	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
223283005904	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
223283005905	putative MFS family transporter protein; Provisional; Region: PRK03633
223283005906	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283005907	putative substrate translocation pore; other site
223283005908	Flagellar regulator YcgR; Region: YcgR; pfam07317
223283005909	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
223283005910	PilZ domain; Region: PilZ; pfam07238
223283005911	FlgN protein; Region: FlgN; pfam05130
223283005912	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
223283005913	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
223283005914	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
223283005915	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
223283005916	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
223283005917	Response regulator receiver domain; Region: Response_reg; pfam00072
223283005918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283005919	active site
223283005920	phosphorylation site [posttranslational modification]
223283005921	intermolecular recognition site; other site
223283005922	dimerization interface [polypeptide binding]; other site
223283005923	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
223283005924	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
223283005925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283005926	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283005927	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283005928	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283005929	cyanate hydratase; Validated; Region: PRK02866
223283005930	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
223283005931	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
223283005932	oligomer interface [polypeptide binding]; other site
223283005933	active site
223283005934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
223283005935	SnoaL-like domain; Region: SnoaL_2; pfam12680
223283005936	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
223283005937	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
223283005938	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
223283005939	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
223283005940	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
223283005941	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
223283005942	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
223283005943	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
223283005944	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
223283005945	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
223283005946	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
223283005947	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
223283005948	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
223283005949	flagellar hook protein FlgE; Validated; Region: flgE; PRK05841
223283005950	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
223283005951	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
223283005952	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
223283005953	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
223283005954	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
223283005955	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
223283005956	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
223283005957	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
223283005958	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
223283005959	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
223283005960	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
223283005961	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
223283005962	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
223283005963	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
223283005964	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
223283005965	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
223283005966	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
223283005967	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
223283005968	flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717
223283005969	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
223283005970	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
223283005971	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
223283005972	active site
223283005973	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
223283005974	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
223283005975	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
223283005976	Probable Catalytic site; other site
223283005977	metal-binding site
223283005978	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283005979	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
223283005980	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
223283005981	active site
223283005982	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
223283005983	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
223283005984	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
223283005985	Probable Catalytic site; other site
223283005986	metal-binding site
223283005987	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
223283005988	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
223283005989	dimer interface [polypeptide binding]; other site
223283005990	active site
223283005991	CoA binding pocket [chemical binding]; other site
223283005992	flagellin; Provisional; Region: PRK12802
223283005993	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
223283005994	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
223283005995	FlaG protein; Region: FlaG; pfam03646
223283005996	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
223283005997	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
223283005998	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
223283005999	flagellar protein FliS; Validated; Region: fliS; PRK05685
223283006000	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
223283006001	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
223283006002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283006003	Walker A motif; other site
223283006004	ATP binding site [chemical binding]; other site
223283006005	Walker B motif; other site
223283006006	arginine finger; other site
223283006007	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283006008	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283006009	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283006010	dimer interface [polypeptide binding]; other site
223283006011	phosphorylation site [posttranslational modification]
223283006012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283006013	ATP binding site [chemical binding]; other site
223283006014	Mg2+ binding site [ion binding]; other site
223283006015	G-X-G motif; other site
223283006016	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
223283006017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006018	active site
223283006019	phosphorylation site [posttranslational modification]
223283006020	intermolecular recognition site; other site
223283006021	dimerization interface [polypeptide binding]; other site
223283006022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283006023	Walker A motif; other site
223283006024	ATP binding site [chemical binding]; other site
223283006025	Walker B motif; other site
223283006026	arginine finger; other site
223283006027	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
223283006028	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
223283006029	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
223283006030	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
223283006031	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
223283006032	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
223283006033	MgtE intracellular N domain; Region: MgtE_N; cl15244
223283006034	FliG C-terminal domain; Region: FliG_C; pfam01706
223283006035	flagellar assembly protein H; Validated; Region: fliH; PRK05687
223283006036	Flagellar assembly protein FliH; Region: FliH; pfam02108
223283006037	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
223283006038	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
223283006039	Walker A motif/ATP binding site; other site
223283006040	Walker B motif; other site
223283006041	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
223283006042	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
223283006043	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
223283006044	anti sigma factor interaction site; other site
223283006045	regulatory phosphorylation site [posttranslational modification]; other site
223283006046	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283006047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006048	active site
223283006049	phosphorylation site [posttranslational modification]
223283006050	intermolecular recognition site; other site
223283006051	dimerization interface [polypeptide binding]; other site
223283006052	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
223283006053	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
223283006054	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
223283006055	putative binding surface; other site
223283006056	active site
223283006057	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
223283006058	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
223283006059	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
223283006060	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
223283006061	flagellar motor switch protein; Validated; Region: fliN; PRK05698
223283006062	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
223283006063	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
223283006064	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
223283006065	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
223283006066	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
223283006067	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
223283006068	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
223283006069	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
223283006070	FHIPEP family; Region: FHIPEP; pfam00771
223283006071	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
223283006072	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
223283006073	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
223283006074	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
223283006075	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
223283006076	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
223283006077	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
223283006078	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283006079	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
223283006080	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283006081	DNA binding residues [nucleotide binding]
223283006082	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
223283006083	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006084	active site
223283006085	phosphorylation site [posttranslational modification]
223283006086	intermolecular recognition site; other site
223283006087	dimerization interface [polypeptide binding]; other site
223283006088	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
223283006089	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
223283006090	putative binding surface; other site
223283006091	active site
223283006092	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
223283006093	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
223283006094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283006095	ATP binding site [chemical binding]; other site
223283006096	Mg2+ binding site [ion binding]; other site
223283006097	G-X-G motif; other site
223283006098	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
223283006099	Response regulator receiver domain; Region: Response_reg; pfam00072
223283006100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006101	active site
223283006102	phosphorylation site [posttranslational modification]
223283006103	intermolecular recognition site; other site
223283006104	dimerization interface [polypeptide binding]; other site
223283006105	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
223283006106	CheB methylesterase; Region: CheB_methylest; pfam01339
223283006107	flagellar motor protein; Reviewed; Region: motC; PRK09109
223283006108	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
223283006109	flagellar motor protein MotD; Reviewed; Region: PRK09038
223283006110	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
223283006111	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
223283006112	ligand binding site [chemical binding]; other site
223283006113	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
223283006114	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
223283006115	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
223283006116	Magnesium ion binding site [ion binding]; other site
223283006117	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
223283006118	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
223283006119	putative CheA interaction surface; other site
223283006120	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
223283006121	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
223283006122	active site
223283006123	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
223283006124	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
223283006125	ligand binding site [chemical binding]; other site
223283006126	flexible hinge region; other site
223283006127	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
223283006128	putative switch regulator; other site
223283006129	non-specific DNA interactions [nucleotide binding]; other site
223283006130	DNA binding site [nucleotide binding]
223283006131	sequence specific DNA binding site [nucleotide binding]; other site
223283006132	putative cAMP binding site [chemical binding]; other site
223283006133	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
223283006134	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283006135	FeS/SAM binding site; other site
223283006136	HemN C-terminal domain; Region: HemN_C; pfam06969
223283006137	Uncharacterized conserved protein [Function unknown]; Region: COG2836
223283006138	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
223283006139	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
223283006140	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
223283006141	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
223283006142	metal-binding site [ion binding]
223283006143	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
223283006144	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283006145	motif II; other site
223283006146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
223283006147	FixH; Region: FixH; pfam05751
223283006148	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
223283006149	4Fe-4S binding domain; Region: Fer4_5; pfam12801
223283006150	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
223283006151	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
223283006152	oligomeric interface; other site
223283006153	putative active site [active]
223283006154	homodimer interface [polypeptide binding]; other site
223283006155	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
223283006156	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
223283006157	Cytochrome c; Region: Cytochrom_C; pfam00034
223283006158	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
223283006159	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
223283006160	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
223283006161	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
223283006162	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
223283006163	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
223283006164	Low-spin heme binding site [chemical binding]; other site
223283006165	Putative water exit pathway; other site
223283006166	Binuclear center (active site) [active]
223283006167	Putative proton exit pathway; other site
223283006168	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
223283006169	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
223283006170	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
223283006171	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
223283006172	Transposase domain (DUF772); Region: DUF772; pfam05598
223283006173	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283006174	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283006175	Transposase domain (DUF772); Region: DUF772; pfam05598
223283006176	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283006177	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283006178	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
223283006179	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
223283006180	Autotransporter beta-domain; Region: Autotransporter; pfam03797
223283006181	PAS domain; Region: PAS_9; pfam13426
223283006182	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283006183	putative active site [active]
223283006184	heme pocket [chemical binding]; other site
223283006185	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283006186	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283006187	dimer interface [polypeptide binding]; other site
223283006188	putative CheW interface [polypeptide binding]; other site
223283006189	CAAX protease self-immunity; Region: Abi; pfam02517
223283006190	aconitate hydratase; Validated; Region: PRK09277
223283006191	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
223283006192	substrate binding site [chemical binding]; other site
223283006193	ligand binding site [chemical binding]; other site
223283006194	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
223283006195	substrate binding site [chemical binding]; other site
223283006196	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
223283006197	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
223283006198	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
223283006199	CPxP  motif; other site
223283006200	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
223283006201	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
223283006202	ligand binding site [chemical binding]; other site
223283006203	NAD binding site [chemical binding]; other site
223283006204	catalytic site [active]
223283006205	homodimer interface [polypeptide binding]; other site
223283006206	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
223283006207	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
223283006208	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283006209	Walker A/P-loop; other site
223283006210	ATP binding site [chemical binding]; other site
223283006211	Q-loop/lid; other site
223283006212	ABC transporter signature motif; other site
223283006213	Walker B; other site
223283006214	D-loop; other site
223283006215	H-loop/switch region; other site
223283006216	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
223283006217	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
223283006218	active site
223283006219	catalytic site [active]
223283006220	substrate binding site [chemical binding]; other site
223283006221	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283006222	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283006223	substrate binding pocket [chemical binding]; other site
223283006224	membrane-bound complex binding site; other site
223283006225	hinge residues; other site
223283006226	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
223283006227	ethanolamine permease; Region: 2A0305; TIGR00908
223283006228	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
223283006229	active site
223283006230	dimer interface [polypeptide binding]; other site
223283006231	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
223283006232	Prostaglandin dehydrogenases; Region: PGDH; cd05288
223283006233	NAD(P) binding site [chemical binding]; other site
223283006234	substrate binding site [chemical binding]; other site
223283006235	dimer interface [polypeptide binding]; other site
223283006236	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
223283006237	dimer interface [polypeptide binding]; other site
223283006238	catalytic triad [active]
223283006239	benzoate transporter; Region: benE; TIGR00843
223283006240	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
223283006241	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
223283006242	putative C-terminal domain interface [polypeptide binding]; other site
223283006243	putative GSH binding site (G-site) [chemical binding]; other site
223283006244	putative dimer interface [polypeptide binding]; other site
223283006245	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
223283006246	N-terminal domain interface [polypeptide binding]; other site
223283006247	dimer interface [polypeptide binding]; other site
223283006248	substrate binding pocket (H-site) [chemical binding]; other site
223283006249	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
223283006250	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
223283006251	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
223283006252	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
223283006253	GTP cyclohydrolase I; Provisional; Region: PLN03044
223283006254	homodecamer interface [polypeptide binding]; other site
223283006255	active site
223283006256	putative catalytic site residues [active]
223283006257	zinc binding site [ion binding]; other site
223283006258	GTP-CH-I/GFRP interaction surface; other site
223283006259	threonyl-tRNA synthetase; Region: PLN02908
223283006260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
223283006261	Smr domain; Region: Smr; pfam01713
223283006262	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
223283006263	Isochorismatase family; Region: Isochorismatase; pfam00857
223283006264	catalytic triad [active]
223283006265	conserved cis-peptide bond; other site
223283006266	HemK family putative methylases; Region: hemK_fam; TIGR00536
223283006267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283006268	S-adenosylmethionine binding site [chemical binding]; other site
223283006269	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
223283006270	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
223283006271	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
223283006272	Tetramer interface [polypeptide binding]; other site
223283006273	active site
223283006274	FMN-binding site [chemical binding]; other site
223283006275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283006276	putative substrate translocation pore; other site
223283006277	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
223283006278	intersubunit interface [polypeptide binding]; other site
223283006279	active site
223283006280	Zn2+ binding site [ion binding]; other site
223283006281	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
223283006282	Cupin domain; Region: Cupin_2; cl17218
223283006283	Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229
223283006284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283006285	motif II; other site
223283006286	Autoinducer binding domain; Region: Autoind_bind; pfam03472
223283006287	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283006288	DNA binding residues [nucleotide binding]
223283006289	dimerization interface [polypeptide binding]; other site
223283006290	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
223283006291	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
223283006292	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
223283006293	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
223283006294	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
223283006295	ZIP Zinc transporter; Region: Zip; pfam02535
223283006296	spermidine synthase; Provisional; Region: PRK00811
223283006297	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283006298	S-adenosylmethionine binding site [chemical binding]; other site
223283006299	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
223283006300	Sulfatase; Region: Sulfatase; pfam00884
223283006301	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
223283006302	Uncharacterized conserved protein [Function unknown]; Region: COG2308
223283006303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
223283006304	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
223283006305	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
223283006306	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
223283006307	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
223283006308	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
223283006309	active site residue [active]
223283006310	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
223283006311	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
223283006312	catalytic triad [active]
223283006313	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
223283006314	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
223283006315	oligomer interface [polypeptide binding]; other site
223283006316	metal binding site [ion binding]; metal-binding site
223283006317	metal binding site [ion binding]; metal-binding site
223283006318	putative Cl binding site [ion binding]; other site
223283006319	basic sphincter; other site
223283006320	hydrophobic gate; other site
223283006321	periplasmic entrance; other site
223283006322	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
223283006323	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
223283006324	substrate binding site [chemical binding]; other site
223283006325	oxyanion hole (OAH) forming residues; other site
223283006326	trimer interface [polypeptide binding]; other site
223283006327	conserved hypothetical protein; Region: TIGR02118
223283006328	Cytochrome c; Region: Cytochrom_C; cl11414
223283006329	Cupin domain; Region: Cupin_2; cl17218
223283006330	PHAGE02; putative prophage; defective prophage region; no integrase found.
223283006331	LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935
223283006332	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
223283006333	Putative phage tail protein; Region: Phage-tail_3; pfam13550
223283006334	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
223283006335	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
223283006336	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
223283006337	Predicted chitinase [General function prediction only]; Region: COG3179
223283006338	catalytic residue [active]
223283006339	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
223283006340	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
223283006341	active site
223283006342	catalytic triad [active]
223283006343	oxyanion hole [active]
223283006344	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
223283006345	classical (c) SDRs; Region: SDR_c; cd05233
223283006346	NAD(P) binding site [chemical binding]; other site
223283006347	active site
223283006348	Isochorismatase family; Region: Isochorismatase; pfam00857
223283006349	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
223283006350	catalytic triad [active]
223283006351	conserved cis-peptide bond; other site
223283006352	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
223283006353	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
223283006354	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283006355	ATP binding site [chemical binding]; other site
223283006356	putative Mg++ binding site [ion binding]; other site
223283006357	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283006358	nucleotide binding region [chemical binding]; other site
223283006359	ATP-binding site [chemical binding]; other site
223283006360	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
223283006361	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
223283006362	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
223283006363	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283006364	ATP binding site [chemical binding]; other site
223283006365	putative Mg++ binding site [ion binding]; other site
223283006366	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283006367	nucleotide binding region [chemical binding]; other site
223283006368	ATP-binding site [chemical binding]; other site
223283006369	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
223283006370	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
223283006371	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
223283006372	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
223283006373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283006374	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283006375	putative substrate translocation pore; other site
223283006376	citrate-proton symporter; Provisional; Region: PRK15075
223283006377	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283006378	putative substrate translocation pore; other site
223283006379	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
223283006380	ApbE family; Region: ApbE; pfam02424
223283006381	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
223283006382	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283006383	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
223283006384	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
223283006385	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
223283006386	active site
223283006387	catalytic site [active]
223283006388	metal binding site [ion binding]; metal-binding site
223283006389	PilZ domain; Region: PilZ; pfam07238
223283006390	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
223283006391	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
223283006392	FtsX-like permease family; Region: FtsX; pfam02687
223283006393	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
223283006394	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
223283006395	Walker A/P-loop; other site
223283006396	ATP binding site [chemical binding]; other site
223283006397	Q-loop/lid; other site
223283006398	ABC transporter signature motif; other site
223283006399	Walker B; other site
223283006400	D-loop; other site
223283006401	H-loop/switch region; other site
223283006402	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
223283006403	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
223283006404	FtsX-like permease family; Region: FtsX; pfam02687
223283006405	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
223283006406	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
223283006407	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
223283006408	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
223283006409	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
223283006410	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
223283006411	PilZ domain; Region: PilZ; pfam07238
223283006412	Response regulator receiver domain; Region: Response_reg; pfam00072
223283006413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006414	active site
223283006415	phosphorylation site [posttranslational modification]
223283006416	intermolecular recognition site; other site
223283006417	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
223283006418	dimerization interface [polypeptide binding]; other site
223283006419	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
223283006420	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
223283006421	anti sigma factor interaction site; other site
223283006422	regulatory phosphorylation site [posttranslational modification]; other site
223283006423	transaldolase-like protein; Provisional; Region: PTZ00411
223283006424	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
223283006425	active site
223283006426	dimer interface [polypeptide binding]; other site
223283006427	catalytic residue [active]
223283006428	glutamate carboxypeptidase; Reviewed; Region: PRK06133
223283006429	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
223283006430	metal binding site [ion binding]; metal-binding site
223283006431	dimer interface [polypeptide binding]; other site
223283006432	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
223283006433	Catalytic site [active]
223283006434	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283006435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283006436	dimer interface [polypeptide binding]; other site
223283006437	phosphorylation site [posttranslational modification]
223283006438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283006439	ATP binding site [chemical binding]; other site
223283006440	Mg2+ binding site [ion binding]; other site
223283006441	G-X-G motif; other site
223283006442	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
223283006443	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
223283006444	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
223283006445	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
223283006446	FMN binding site [chemical binding]; other site
223283006447	active site
223283006448	catalytic residues [active]
223283006449	substrate binding site [chemical binding]; other site
223283006450	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
223283006451	Ligand Binding Site [chemical binding]; other site
223283006452	Response regulator receiver domain; Region: Response_reg; pfam00072
223283006453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006454	active site
223283006455	phosphorylation site [posttranslational modification]
223283006456	intermolecular recognition site; other site
223283006457	dimerization interface [polypeptide binding]; other site
223283006458	CHASE3 domain; Region: CHASE3; pfam05227
223283006459	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
223283006460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283006461	putative active site [active]
223283006462	heme pocket [chemical binding]; other site
223283006463	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283006464	dimer interface [polypeptide binding]; other site
223283006465	phosphorylation site [posttranslational modification]
223283006466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283006467	ATP binding site [chemical binding]; other site
223283006468	G-X-G motif; other site
223283006469	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283006470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006471	active site
223283006472	phosphorylation site [posttranslational modification]
223283006473	intermolecular recognition site; other site
223283006474	dimerization interface [polypeptide binding]; other site
223283006475	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283006476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006477	active site
223283006478	phosphorylation site [posttranslational modification]
223283006479	intermolecular recognition site; other site
223283006480	dimerization interface [polypeptide binding]; other site
223283006481	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283006482	DNA binding residues [nucleotide binding]
223283006483	dimerization interface [polypeptide binding]; other site
223283006484	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
223283006485	Histidine kinase; Region: HisKA_3; pfam07730
223283006486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283006487	ATP binding site [chemical binding]; other site
223283006488	Mg2+ binding site [ion binding]; other site
223283006489	G-X-G motif; other site
223283006490	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
223283006491	SnoaL-like domain; Region: SnoaL_3; pfam13474
223283006492	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
223283006493	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283006494	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283006495	DNA binding residues [nucleotide binding]
223283006496	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
223283006497	peptide synthase; Validated; Region: PRK05691
223283006498	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
223283006499	acyl-activating enzyme (AAE) consensus motif; other site
223283006500	active site
223283006501	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006502	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283006503	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283006504	acyl-activating enzyme (AAE) consensus motif; other site
223283006505	AMP binding site [chemical binding]; other site
223283006506	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006507	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283006508	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283006509	acyl-activating enzyme (AAE) consensus motif; other site
223283006510	AMP binding site [chemical binding]; other site
223283006511	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006512	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
223283006513	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283006514	acyl-activating enzyme (AAE) consensus motif; other site
223283006515	AMP binding site [chemical binding]; other site
223283006516	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006517	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
223283006518	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283006519	inhibitor-cofactor binding pocket; inhibition site
223283006520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283006521	catalytic residue [active]
223283006522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
223283006523	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
223283006524	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
223283006525	intersubunit interface [polypeptide binding]; other site
223283006526	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
223283006527	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
223283006528	ABC-ATPase subunit  interface; other site
223283006529	dimer interface [polypeptide binding]; other site
223283006530	putative PBP binding regions; other site
223283006531	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
223283006532	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
223283006533	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
223283006534	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
223283006535	metal binding site [ion binding]; metal-binding site
223283006536	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
223283006537	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
223283006538	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
223283006539	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
223283006540	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
223283006541	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
223283006542	Condensation domain; Region: Condensation; pfam00668
223283006543	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283006544	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283006545	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283006546	acyl-activating enzyme (AAE) consensus motif; other site
223283006547	AMP binding site [chemical binding]; other site
223283006548	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006549	Condensation domain; Region: Condensation; pfam00668
223283006550	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283006551	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283006552	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283006553	acyl-activating enzyme (AAE) consensus motif; other site
223283006554	AMP binding site [chemical binding]; other site
223283006555	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006556	Condensation domain; Region: Condensation; pfam00668
223283006557	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283006558	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
223283006559	Condensation domain; Region: Condensation; pfam00668
223283006560	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283006561	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283006562	acyl-activating enzyme (AAE) consensus motif; other site
223283006563	AMP binding site [chemical binding]; other site
223283006564	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006565	Condensation domain; Region: Condensation; pfam00668
223283006566	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283006567	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283006568	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283006569	acyl-activating enzyme (AAE) consensus motif; other site
223283006570	AMP binding site [chemical binding]; other site
223283006571	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006572	Condensation domain; Region: Condensation; pfam00668
223283006573	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283006574	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283006575	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283006576	acyl-activating enzyme (AAE) consensus motif; other site
223283006577	AMP binding site [chemical binding]; other site
223283006578	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006579	Condensation domain; Region: Condensation; pfam00668
223283006580	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283006581	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283006582	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283006583	acyl-activating enzyme (AAE) consensus motif; other site
223283006584	AMP binding site [chemical binding]; other site
223283006585	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006586	Condensation domain; Region: Condensation; pfam00668
223283006587	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283006588	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
223283006589	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
223283006590	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283006591	acyl-activating enzyme (AAE) consensus motif; other site
223283006592	AMP binding site [chemical binding]; other site
223283006593	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283006594	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
223283006595	Secretin and TonB N terminus short domain; Region: STN; smart00965
223283006596	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283006597	N-terminal plug; other site
223283006598	ligand-binding site [chemical binding]; other site
223283006599	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
223283006600	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283006601	N-terminal plug; other site
223283006602	ligand-binding site [chemical binding]; other site
223283006603	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
223283006604	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
223283006605	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283006606	Walker A/P-loop; other site
223283006607	ATP binding site [chemical binding]; other site
223283006608	Q-loop/lid; other site
223283006609	ABC transporter signature motif; other site
223283006610	Walker B; other site
223283006611	D-loop; other site
223283006612	H-loop/switch region; other site
223283006613	Uncharacterized conserved protein [Function unknown]; Region: COG1262
223283006614	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
223283006615	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
223283006616	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
223283006617	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283006618	catalytic residue [active]
223283006619	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
223283006620	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
223283006621	active site
223283006622	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
223283006623	calcium-activated chloride channel protein 1; Region: hCaCC; TIGR00868
223283006624	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
223283006625	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
223283006626	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
223283006627	Walker A/P-loop; other site
223283006628	ATP binding site [chemical binding]; other site
223283006629	Q-loop/lid; other site
223283006630	ABC transporter signature motif; other site
223283006631	Walker B; other site
223283006632	D-loop; other site
223283006633	H-loop/switch region; other site
223283006634	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
223283006635	FtsX-like permease family; Region: FtsX; pfam02687
223283006636	macrolide transporter subunit MacA; Provisional; Region: PRK11578
223283006637	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
223283006638	E3 interaction surface; other site
223283006639	lipoyl attachment site [posttranslational modification]; other site
223283006640	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283006641	Penicillin amidase; Region: Penicil_amidase; pfam01804
223283006642	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
223283006643	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
223283006644	active site
223283006645	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
223283006646	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
223283006647	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283006648	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283006649	homodimer interface [polypeptide binding]; other site
223283006650	catalytic residue [active]
223283006651	excinuclease ABC subunit B; Provisional; Region: PRK05298
223283006652	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283006653	ATP binding site [chemical binding]; other site
223283006654	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283006655	nucleotide binding region [chemical binding]; other site
223283006656	ATP-binding site [chemical binding]; other site
223283006657	Ultra-violet resistance protein B; Region: UvrB; pfam12344
223283006658	UvrB/uvrC motif; Region: UVR; pfam02151
223283006659	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
223283006660	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
223283006661	putative active site [active]
223283006662	putative NTP binding site [chemical binding]; other site
223283006663	putative nucleic acid binding site [nucleotide binding]; other site
223283006664	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
223283006665	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
223283006666	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
223283006667	HIGH motif; other site
223283006668	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
223283006669	active site
223283006670	KMSKS motif; other site
223283006671	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
223283006672	Transposase; Region: DEDD_Tnp_IS110; pfam01548
223283006673	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
223283006674	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
223283006675	active site
223283006676	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
223283006677	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
223283006678	FMN binding site [chemical binding]; other site
223283006679	active site
223283006680	catalytic residues [active]
223283006681	substrate binding site [chemical binding]; other site
223283006682	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
223283006683	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
223283006684	putative dimer interface [polypeptide binding]; other site
223283006685	PAS fold; Region: PAS_3; pfam08447
223283006686	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
223283006687	PAS domain S-box; Region: sensory_box; TIGR00229
223283006688	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283006689	putative active site [active]
223283006690	heme pocket [chemical binding]; other site
223283006691	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283006692	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283006693	metal binding site [ion binding]; metal-binding site
223283006694	active site
223283006695	I-site; other site
223283006696	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283006697	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283006698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283006699	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
223283006700	dimerization interface [polypeptide binding]; other site
223283006701	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
223283006702	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
223283006703	substrate binding site [chemical binding]; other site
223283006704	ligand binding site [chemical binding]; other site
223283006705	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
223283006706	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
223283006707	substrate binding site [chemical binding]; other site
223283006708	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
223283006709	tartrate dehydrogenase; Region: TTC; TIGR02089
223283006710	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
223283006711	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
223283006712	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
223283006713	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
223283006714	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
223283006715	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
223283006716	active site
223283006717	intersubunit interface [polypeptide binding]; other site
223283006718	catalytic residue [active]
223283006719	galactonate dehydratase; Provisional; Region: PRK14017
223283006720	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
223283006721	putative active site pocket [active]
223283006722	putative metal binding site [ion binding]; other site
223283006723	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283006724	D-galactonate transporter; Region: 2A0114; TIGR00893
223283006725	putative substrate translocation pore; other site
223283006726	Transcriptional regulator [Transcription]; Region: IclR; COG1414
223283006727	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
223283006728	Bacterial transcriptional regulator; Region: IclR; pfam01614
223283006729	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
223283006730	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
223283006731	putative NAD(P) binding site [chemical binding]; other site
223283006732	putative substrate binding site [chemical binding]; other site
223283006733	catalytic Zn binding site [ion binding]; other site
223283006734	structural Zn binding site [ion binding]; other site
223283006735	dimer interface [polypeptide binding]; other site
223283006736	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
223283006737	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
223283006738	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283006739	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
223283006740	Ligand binding site [chemical binding]; other site
223283006741	Electron transfer flavoprotein domain; Region: ETF; pfam01012
223283006742	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
223283006743	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
223283006744	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
223283006745	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283006746	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283006747	substrate binding pocket [chemical binding]; other site
223283006748	membrane-bound complex binding site; other site
223283006749	hinge residues; other site
223283006750	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
223283006751	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
223283006752	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
223283006753	ligand binding site [chemical binding]; other site
223283006754	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
223283006755	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283006756	DNA-binding site [nucleotide binding]; DNA binding site
223283006757	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283006758	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283006759	homodimer interface [polypeptide binding]; other site
223283006760	catalytic residue [active]
223283006761	Flagellin N-methylase; Region: FliB; cl00497
223283006762	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
223283006763	putative lipid binding site [chemical binding]; other site
223283006764	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
223283006765	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
223283006766	dimer interface [polypeptide binding]; other site
223283006767	active site
223283006768	citrylCoA binding site [chemical binding]; other site
223283006769	NADH binding [chemical binding]; other site
223283006770	cationic pore residues; other site
223283006771	oxalacetate/citrate binding site [chemical binding]; other site
223283006772	coenzyme A binding site [chemical binding]; other site
223283006773	catalytic triad [active]
223283006774	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
223283006775	Iron-sulfur protein interface; other site
223283006776	proximal quinone binding site [chemical binding]; other site
223283006777	SdhD (CybS) interface [polypeptide binding]; other site
223283006778	proximal heme binding site [chemical binding]; other site
223283006779	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
223283006780	SdhC subunit interface [polypeptide binding]; other site
223283006781	proximal heme binding site [chemical binding]; other site
223283006782	cardiolipin binding site; other site
223283006783	Iron-sulfur protein interface; other site
223283006784	proximal quinone binding site [chemical binding]; other site
223283006785	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
223283006786	L-aspartate oxidase; Provisional; Region: PRK06175
223283006787	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
223283006788	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
223283006789	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
223283006790	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
223283006791	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
223283006792	TPP-binding site [chemical binding]; other site
223283006793	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
223283006794	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
223283006795	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
223283006796	E3 interaction surface; other site
223283006797	lipoyl attachment site [posttranslational modification]; other site
223283006798	e3 binding domain; Region: E3_binding; pfam02817
223283006799	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
223283006800	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
223283006801	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
223283006802	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283006803	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
223283006804	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
223283006805	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
223283006806	CoA-ligase; Region: Ligase_CoA; pfam00549
223283006807	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
223283006808	CoA binding domain; Region: CoA_binding; pfam02629
223283006809	CoA-ligase; Region: Ligase_CoA; pfam00549
223283006810	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283006811	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283006812	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283006813	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
223283006814	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
223283006815	heat shock protein 90; Provisional; Region: PRK05218
223283006816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283006817	ATP binding site [chemical binding]; other site
223283006818	Mg2+ binding site [ion binding]; other site
223283006819	G-X-G motif; other site
223283006820	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
223283006821	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
223283006822	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
223283006823	dimer interface [polypeptide binding]; other site
223283006824	active site
223283006825	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
223283006826	active site 1 [active]
223283006827	dimer interface [polypeptide binding]; other site
223283006828	active site 2 [active]
223283006829	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283006830	dimerization interface [polypeptide binding]; other site
223283006831	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283006832	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283006833	dimer interface [polypeptide binding]; other site
223283006834	phosphorylation site [posttranslational modification]
223283006835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283006836	ATP binding site [chemical binding]; other site
223283006837	Mg2+ binding site [ion binding]; other site
223283006838	G-X-G motif; other site
223283006839	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283006840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006841	active site
223283006842	phosphorylation site [posttranslational modification]
223283006843	intermolecular recognition site; other site
223283006844	dimerization interface [polypeptide binding]; other site
223283006845	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
223283006846	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
223283006847	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
223283006848	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
223283006849	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
223283006850	catalytic core [active]
223283006851	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
223283006852	CoenzymeA binding site [chemical binding]; other site
223283006853	subunit interaction site [polypeptide binding]; other site
223283006854	PHB binding site; other site
223283006855	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
223283006856	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
223283006857	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
223283006858	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
223283006859	Domain of unknown function DUF20; Region: UPF0118; pfam01594
223283006860	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283006861	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283006862	dimerization interface [polypeptide binding]; other site
223283006863	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283006864	dimer interface [polypeptide binding]; other site
223283006865	phosphorylation site [posttranslational modification]
223283006866	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283006867	ATP binding site [chemical binding]; other site
223283006868	Mg2+ binding site [ion binding]; other site
223283006869	G-X-G motif; other site
223283006870	osmolarity response regulator; Provisional; Region: ompR; PRK09468
223283006871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006872	active site
223283006873	phosphorylation site [posttranslational modification]
223283006874	intermolecular recognition site; other site
223283006875	dimerization interface [polypeptide binding]; other site
223283006876	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283006877	DNA binding site [nucleotide binding]
223283006878	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
223283006879	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
223283006880	Autotransporter beta-domain; Region: Autotransporter; pfam03797
223283006881	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
223283006882	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
223283006883	PapC N-terminal domain; Region: PapC_N; pfam13954
223283006884	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
223283006885	PapC C-terminal domain; Region: PapC_C; pfam13953
223283006886	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
223283006887	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
223283006888	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
223283006889	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
223283006890	RHS Repeat; Region: RHS_repeat; pfam05593
223283006891	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
223283006892	Transposase domain (DUF772); Region: DUF772; pfam05598
223283006893	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283006894	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283006895	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
223283006896	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283006897	DNA binding residues [nucleotide binding]
223283006898	dimerization interface [polypeptide binding]; other site
223283006899	K+-transporting ATPase, KdpF subunit; Region: potass_kdpF; TIGR02115
223283006900	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
223283006901	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
223283006902	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
223283006903	Soluble P-type ATPase [General function prediction only]; Region: COG4087
223283006904	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
223283006905	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
223283006906	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
223283006907	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
223283006908	Ligand Binding Site [chemical binding]; other site
223283006909	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
223283006910	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432
223283006911	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283006912	dimer interface [polypeptide binding]; other site
223283006913	phosphorylation site [posttranslational modification]
223283006914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283006915	ATP binding site [chemical binding]; other site
223283006916	Mg2+ binding site [ion binding]; other site
223283006917	G-X-G motif; other site
223283006918	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
223283006919	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283006920	active site
223283006921	phosphorylation site [posttranslational modification]
223283006922	intermolecular recognition site; other site
223283006923	dimerization interface [polypeptide binding]; other site
223283006924	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283006925	DNA binding site [nucleotide binding]
223283006926	MoxR-like ATPases [General function prediction only]; Region: COG0714
223283006927	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283006928	Walker A motif; other site
223283006929	ATP binding site [chemical binding]; other site
223283006930	Walker B motif; other site
223283006931	arginine finger; other site
223283006932	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
223283006933	Protein of unknown function DUF58; Region: DUF58; pfam01882
223283006934	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
223283006935	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
223283006936	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
223283006937	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
223283006938	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283006939	dimerization interface [polypeptide binding]; other site
223283006940	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283006941	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283006942	dimer interface [polypeptide binding]; other site
223283006943	putative CheW interface [polypeptide binding]; other site
223283006944	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
223283006945	active site
223283006946	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283006947	substrate binding pocket [chemical binding]; other site
223283006948	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
223283006949	membrane-bound complex binding site; other site
223283006950	hinge residues; other site
223283006951	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
223283006952	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283006953	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283006954	catalytic residue [active]
223283006955	DoxX; Region: DoxX; pfam07681
223283006956	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
223283006957	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283006958	Walker A motif; other site
223283006959	ATP binding site [chemical binding]; other site
223283006960	Walker B motif; other site
223283006961	arginine finger; other site
223283006962	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283006963	Protein of unknown function (DUF917); Region: DUF917; pfam06032
223283006964	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
223283006965	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
223283006966	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
223283006967	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
223283006968	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
223283006969	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
223283006970	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
223283006971	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
223283006972	Walker A/P-loop; other site
223283006973	ATP binding site [chemical binding]; other site
223283006974	Q-loop/lid; other site
223283006975	ABC transporter signature motif; other site
223283006976	Walker B; other site
223283006977	D-loop; other site
223283006978	H-loop/switch region; other site
223283006979	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
223283006980	active site
223283006981	catalytic triad [active]
223283006982	oxyanion hole [active]
223283006983	switch loop; other site
223283006984	L,D-transpeptidase; Provisional; Region: PRK10260
223283006985	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
223283006986	Predicted acetyltransferase [General function prediction only]; Region: COG2388
223283006987	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
223283006988	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
223283006989	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
223283006990	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
223283006991	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
223283006992	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
223283006993	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
223283006994	Ligand Binding Site [chemical binding]; other site
223283006995	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
223283006996	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283006997	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
223283006998	substrate binding site [chemical binding]; other site
223283006999	dimerization interface [polypeptide binding]; other site
223283007000	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
223283007001	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
223283007002	Active Sites [active]
223283007003	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
223283007004	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
223283007005	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
223283007006	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
223283007007	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
223283007008	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
223283007009	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
223283007010	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
223283007011	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
223283007012	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
223283007013	Transcriptional regulators [Transcription]; Region: GntR; COG1802
223283007014	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283007015	DNA-binding site [nucleotide binding]; DNA binding site
223283007016	FCD domain; Region: FCD; pfam07729
223283007017	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
223283007018	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
223283007019	tetramer interface [polypeptide binding]; other site
223283007020	active site
223283007021	Mg2+/Mn2+ binding site [ion binding]; other site
223283007022	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
223283007023	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
223283007024	dimer interface [polypeptide binding]; other site
223283007025	active site
223283007026	citrylCoA binding site [chemical binding]; other site
223283007027	oxalacetate/citrate binding site [chemical binding]; other site
223283007028	coenzyme A binding site [chemical binding]; other site
223283007029	catalytic triad [active]
223283007030	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
223283007031	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
223283007032	substrate binding site [chemical binding]; other site
223283007033	ligand binding site [chemical binding]; other site
223283007034	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
223283007035	substrate binding site [chemical binding]; other site
223283007036	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
223283007037	PEP synthetase regulatory protein; Provisional; Region: PRK05339
223283007038	phosphoenolpyruvate synthase; Validated; Region: PRK06464
223283007039	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
223283007040	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
223283007041	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
223283007042	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
223283007043	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
223283007044	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
223283007045	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
223283007046	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
223283007047	Cl binding site [ion binding]; other site
223283007048	oligomer interface [polypeptide binding]; other site
223283007049	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
223283007050	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283007051	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283007052	DNA binding residues [nucleotide binding]
223283007053	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
223283007054	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
223283007055	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
223283007056	ligand binding site [chemical binding]; other site
223283007057	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
223283007058	active site
223283007059	SAM binding site [chemical binding]; other site
223283007060	homodimer interface [polypeptide binding]; other site
223283007061	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
223283007062	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
223283007063	[4Fe-4S] binding site [ion binding]; other site
223283007064	molybdopterin cofactor binding site; other site
223283007065	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
223283007066	molybdopterin cofactor binding site; other site
223283007067	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
223283007068	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
223283007069	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283007070	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
223283007071	Catalytic domain of Protein Kinases; Region: PKc; cd00180
223283007072	active site
223283007073	ATP binding site [chemical binding]; other site
223283007074	substrate binding site [chemical binding]; other site
223283007075	activation loop (A-loop); other site
223283007076	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
223283007077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283007078	putative substrate translocation pore; other site
223283007079	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
223283007080	active site
223283007081	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
223283007082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283007083	active site
223283007084	phosphorylation site [posttranslational modification]
223283007085	intermolecular recognition site; other site
223283007086	dimerization interface [polypeptide binding]; other site
223283007087	ANTAR domain; Region: ANTAR; pfam03861
223283007088	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
223283007089	NMT1-like family; Region: NMT1_2; pfam13379
223283007090	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
223283007091	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
223283007092	quinone interaction residues [chemical binding]; other site
223283007093	active site
223283007094	catalytic residues [active]
223283007095	FMN binding site [chemical binding]; other site
223283007096	substrate binding site [chemical binding]; other site
223283007097	Ribosome modulation factor; Region: RMF; pfam04957
223283007098	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
223283007099	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
223283007100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
223283007101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283007102	S-adenosylmethionine binding site [chemical binding]; other site
223283007103	CHASE domain; Region: CHASE; pfam03924
223283007104	PAS fold; Region: PAS; pfam00989
223283007105	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283007106	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283007107	PAS fold; Region: PAS_3; pfam08447
223283007108	putative active site [active]
223283007109	heme pocket [chemical binding]; other site
223283007110	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283007111	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283007112	metal binding site [ion binding]; metal-binding site
223283007113	active site
223283007114	I-site; other site
223283007115	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
223283007116	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
223283007117	hypothetical protein; Provisional; Region: PRK11702
223283007118	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283007119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283007120	ATP binding site [chemical binding]; other site
223283007121	Mg2+ binding site [ion binding]; other site
223283007122	G-X-G motif; other site
223283007123	Response regulator receiver domain; Region: Response_reg; pfam00072
223283007124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283007125	active site
223283007126	phosphorylation site [posttranslational modification]
223283007127	intermolecular recognition site; other site
223283007128	dimerization interface [polypeptide binding]; other site
223283007129	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
223283007130	putative binding surface; other site
223283007131	active site
223283007132	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
223283007133	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
223283007134	catalytic residues [active]
223283007135	catalytic nucleophile [active]
223283007136	Recombinase; Region: Recombinase; pfam07508
223283007137	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
223283007138	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
223283007139	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
223283007140	Presynaptic Site I dimer interface [polypeptide binding]; other site
223283007141	catalytic residues [active]
223283007142	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
223283007143	Synaptic Flat tetramer interface [polypeptide binding]; other site
223283007144	Synaptic Site I dimer interface [polypeptide binding]; other site
223283007145	DNA binding site [nucleotide binding]
223283007146	Helix-turn-helix domain; Region: HTH_38; pfam13936
223283007147	DNA-binding interface [nucleotide binding]; DNA binding site
223283007148	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283007149	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283007150	DNA-binding interface [nucleotide binding]; DNA binding site
223283007151	Integrase core domain; Region: rve; pfam00665
223283007152	Integrase core domain; Region: rve_3; cl15866
223283007153	transposase/IS protein; Provisional; Region: PRK09183
223283007154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283007155	Walker A motif; other site
223283007156	ATP binding site [chemical binding]; other site
223283007157	Walker B motif; other site
223283007158	Transposase domain (DUF772); Region: DUF772; pfam05598
223283007159	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283007160	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283007161	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283007162	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283007163	substrate binding pocket [chemical binding]; other site
223283007164	membrane-bound complex binding site; other site
223283007165	hinge residues; other site
223283007166	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283007167	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283007168	substrate binding pocket [chemical binding]; other site
223283007169	membrane-bound complex binding site; other site
223283007170	hinge residues; other site
223283007171	PAS fold; Region: PAS_4; pfam08448
223283007172	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283007173	putative active site [active]
223283007174	heme pocket [chemical binding]; other site
223283007175	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283007176	phosphorylation site [posttranslational modification]
223283007177	Transposase domain (DUF772); Region: DUF772; pfam05598
223283007178	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283007179	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283007180	Response regulator receiver domain; Region: Response_reg; pfam00072
223283007181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283007182	active site
223283007183	phosphorylation site [posttranslational modification]
223283007184	intermolecular recognition site; other site
223283007185	dimerization interface [polypeptide binding]; other site
223283007186	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
223283007187	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
223283007188	Zn2+ binding site [ion binding]; other site
223283007189	Mg2+ binding site [ion binding]; other site
223283007190	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
223283007191	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
223283007192	Predicted membrane protein [Function unknown]; Region: COG5393
223283007193	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
223283007194	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
223283007195	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
223283007196	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
223283007197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283007198	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283007199	dimerization interface [polypeptide binding]; other site
223283007200	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
223283007201	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
223283007202	active site
223283007203	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
223283007204	heterodimer interface [polypeptide binding]; other site
223283007205	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
223283007206	active site
223283007207	benzoate transport; Region: 2A0115; TIGR00895
223283007208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283007209	putative substrate translocation pore; other site
223283007210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283007211	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
223283007212	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
223283007213	tetramer interface [polypeptide binding]; other site
223283007214	active site
223283007215	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
223283007216	outer membrane porin, OprD family; Region: OprD; pfam03573
223283007217	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
223283007218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283007219	D-galactonate transporter; Region: 2A0114; TIGR00893
223283007220	putative substrate translocation pore; other site
223283007221	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
223283007222	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
223283007223	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
223283007224	dimer interface [polypeptide binding]; other site
223283007225	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
223283007226	active site
223283007227	Fe binding site [ion binding]; other site
223283007228	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283007229	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283007230	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
223283007231	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
223283007232	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
223283007233	shikimate binding site; other site
223283007234	NAD(P) binding site [chemical binding]; other site
223283007235	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
223283007236	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
223283007237	probable active site [active]
223283007238	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
223283007239	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
223283007240	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
223283007241	GTP binding site; other site
223283007242	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
223283007243	MPT binding site; other site
223283007244	trimer interface [polypeptide binding]; other site
223283007245	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
223283007246	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
223283007247	dimer interface [polypeptide binding]; other site
223283007248	putative functional site; other site
223283007249	putative MPT binding site; other site
223283007250	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
223283007251	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
223283007252	active site
223283007253	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
223283007254	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
223283007255	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
223283007256	TrkA-N domain; Region: TrkA_N; pfam02254
223283007257	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
223283007258	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
223283007259	FecR protein; Region: FecR; pfam04773
223283007260	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
223283007261	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
223283007262	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
223283007263	active site
223283007264	DNA-specific endonuclease I; Provisional; Region: PRK15137
223283007265	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
223283007266	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
223283007267	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
223283007268	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
223283007269	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
223283007270	ligand binding site [chemical binding]; other site
223283007271	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
223283007272	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
223283007273	Walker A/P-loop; other site
223283007274	ATP binding site [chemical binding]; other site
223283007275	Q-loop/lid; other site
223283007276	ABC transporter signature motif; other site
223283007277	Walker B; other site
223283007278	D-loop; other site
223283007279	H-loop/switch region; other site
223283007280	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
223283007281	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283007282	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
223283007283	TM-ABC transporter signature motif; other site
223283007284	Transcriptional regulators [Transcription]; Region: PurR; COG1609
223283007285	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
223283007286	DNA binding site [nucleotide binding]
223283007287	domain linker motif; other site
223283007288	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
223283007289	dimerization interface [polypeptide binding]; other site
223283007290	ligand binding site [chemical binding]; other site
223283007291	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
223283007292	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
223283007293	substrate binding site [chemical binding]; other site
223283007294	dimer interface [polypeptide binding]; other site
223283007295	ATP binding site [chemical binding]; other site
223283007296	D-ribose pyranase; Provisional; Region: PRK11797
223283007297	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
223283007298	active site
223283007299	tetramer interface [polypeptide binding]; other site
223283007300	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
223283007301	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
223283007302	DNA-binding site [nucleotide binding]; DNA binding site
223283007303	RNA-binding motif; other site
223283007304	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
223283007305	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
223283007306	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
223283007307	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
223283007308	active site
223283007309	dimer interface [polypeptide binding]; other site
223283007310	motif 1; other site
223283007311	motif 2; other site
223283007312	motif 3; other site
223283007313	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
223283007314	anticodon binding site; other site
223283007315	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
223283007316	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
223283007317	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
223283007318	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
223283007319	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
223283007320	23S rRNA binding site [nucleotide binding]; other site
223283007321	L21 binding site [polypeptide binding]; other site
223283007322	L13 binding site [polypeptide binding]; other site
223283007323	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
223283007324	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
223283007325	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
223283007326	dimer interface [polypeptide binding]; other site
223283007327	motif 1; other site
223283007328	active site
223283007329	motif 2; other site
223283007330	motif 3; other site
223283007331	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
223283007332	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
223283007333	putative tRNA-binding site [nucleotide binding]; other site
223283007334	B3/4 domain; Region: B3_4; pfam03483
223283007335	tRNA synthetase B5 domain; Region: B5; smart00874
223283007336	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
223283007337	dimer interface [polypeptide binding]; other site
223283007338	motif 1; other site
223283007339	motif 3; other site
223283007340	motif 2; other site
223283007341	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
223283007342	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
223283007343	IHF dimer interface [polypeptide binding]; other site
223283007344	IHF - DNA interface [nucleotide binding]; other site
223283007345	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
223283007346	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
223283007347	DNA binding residues [nucleotide binding]
223283007348	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
223283007349	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
223283007350	cofactor binding site; other site
223283007351	DNA binding site [nucleotide binding]
223283007352	substrate interaction site [chemical binding]; other site
223283007353	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283007354	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283007355	DNA-binding interface [nucleotide binding]; DNA binding site
223283007356	Integrase core domain; Region: rve; pfam00665
223283007357	Integrase core domain; Region: rve_3; cl15866
223283007358	transposase/IS protein; Provisional; Region: PRK09183
223283007359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283007360	Walker A motif; other site
223283007361	ATP binding site [chemical binding]; other site
223283007362	Walker B motif; other site
223283007363	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
223283007364	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
223283007365	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283007366	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283007367	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
223283007368	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283007369	Radical SAM superfamily; Region: Radical_SAM; pfam04055
223283007370	FeS/SAM binding site; other site
223283007371	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
223283007372	MarR family; Region: MarR_2; cl17246
223283007373	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
223283007374	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
223283007375	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
223283007376	NAD binding site [chemical binding]; other site
223283007377	homotetramer interface [polypeptide binding]; other site
223283007378	homodimer interface [polypeptide binding]; other site
223283007379	active site
223283007380	substrate binding site [chemical binding]; other site
223283007381	short chain dehydrogenase; Provisional; Region: PRK06114
223283007382	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283007383	NAD(P) binding site [chemical binding]; other site
223283007384	active site
223283007385	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
223283007386	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
223283007387	Walker A/P-loop; other site
223283007388	ATP binding site [chemical binding]; other site
223283007389	Q-loop/lid; other site
223283007390	ABC transporter signature motif; other site
223283007391	Walker B; other site
223283007392	D-loop; other site
223283007393	H-loop/switch region; other site
223283007394	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
223283007395	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
223283007396	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
223283007397	ligand binding site [chemical binding]; other site
223283007398	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283007399	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
223283007400	TM-ABC transporter signature motif; other site
223283007401	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
223283007402	TPP-binding site [chemical binding]; other site
223283007403	dimer interface [polypeptide binding]; other site
223283007404	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
223283007405	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
223283007406	PYR/PP interface [polypeptide binding]; other site
223283007407	dimer interface [polypeptide binding]; other site
223283007408	TPP binding site [chemical binding]; other site
223283007409	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
223283007410	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
223283007411	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
223283007412	N- and C-terminal domain interface [polypeptide binding]; other site
223283007413	active site
223283007414	MgATP binding site [chemical binding]; other site
223283007415	catalytic site [active]
223283007416	metal binding site [ion binding]; metal-binding site
223283007417	putative homotetramer interface [polypeptide binding]; other site
223283007418	putative homodimer interface [polypeptide binding]; other site
223283007419	glycerol binding site [chemical binding]; other site
223283007420	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283007421	dimerization interface [polypeptide binding]; other site
223283007422	putative DNA binding site [nucleotide binding]; other site
223283007423	putative Zn2+ binding site [ion binding]; other site
223283007424	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
223283007425	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
223283007426	active site
223283007427	FMN binding site [chemical binding]; other site
223283007428	substrate binding site [chemical binding]; other site
223283007429	homotetramer interface [polypeptide binding]; other site
223283007430	catalytic residue [active]
223283007431	Predicted transcriptional regulator [Transcription]; Region: COG1959
223283007432	Transcriptional regulator; Region: Rrf2; pfam02082
223283007433	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
223283007434	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
223283007435	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
223283007436	UreD urease accessory protein; Region: UreD; pfam01774
223283007437	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
223283007438	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
223283007439	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
223283007440	alpha-gamma subunit interface [polypeptide binding]; other site
223283007441	beta-gamma subunit interface [polypeptide binding]; other site
223283007442	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
223283007443	alpha-beta subunit interface [polypeptide binding]; other site
223283007444	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
223283007445	UreF; Region: UreF; pfam01730
223283007446	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
223283007447	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
223283007448	dimer interface [polypeptide binding]; other site
223283007449	catalytic residues [active]
223283007450	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
223283007451	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
223283007452	Walker A/P-loop; other site
223283007453	ATP binding site [chemical binding]; other site
223283007454	Q-loop/lid; other site
223283007455	ABC transporter signature motif; other site
223283007456	Walker B; other site
223283007457	D-loop; other site
223283007458	H-loop/switch region; other site
223283007459	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
223283007460	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
223283007461	Walker A/P-loop; other site
223283007462	ATP binding site [chemical binding]; other site
223283007463	Q-loop/lid; other site
223283007464	ABC transporter signature motif; other site
223283007465	Walker B; other site
223283007466	D-loop; other site
223283007467	H-loop/switch region; other site
223283007468	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
223283007469	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
223283007470	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
223283007471	TM-ABC transporter signature motif; other site
223283007472	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283007473	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
223283007474	TM-ABC transporter signature motif; other site
223283007475	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
223283007476	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
223283007477	putative ligand binding site [chemical binding]; other site
223283007478	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
223283007479	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
223283007480	ligand binding site [chemical binding]; other site
223283007481	regulator interaction site; other site
223283007482	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
223283007483	ANTAR domain; Region: ANTAR; pfam03861
223283007484	amidase; Provisional; Region: PRK07235
223283007485	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
223283007486	DNA recombination protein RmuC; Provisional; Region: PRK10361
223283007487	RmuC family; Region: RmuC; pfam02646
223283007488	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
223283007489	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283007490	substrate binding pocket [chemical binding]; other site
223283007491	membrane-bound complex binding site; other site
223283007492	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180
223283007493	putative ligand binding site [chemical binding]; other site
223283007494	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
223283007495	putative NAD binding site [chemical binding]; other site
223283007496	catalytic site [active]
223283007497	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
223283007498	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
223283007499	active site
223283007500	non-prolyl cis peptide bond; other site
223283007501	Transposase domain (DUF772); Region: DUF772; pfam05598
223283007502	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283007503	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283007504	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
223283007505	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283007506	catalytic residue [active]
223283007507	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
223283007508	putative efflux protein, MATE family; Region: matE; TIGR00797
223283007509	cation binding site [ion binding]; other site
223283007510	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
223283007511	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
223283007512	active site
223283007513	AMP binding site [chemical binding]; other site
223283007514	acyl-activating enzyme (AAE) consensus motif; other site
223283007515	CoA binding site [chemical binding]; other site
223283007516	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
223283007517	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
223283007518	dimer interface [polypeptide binding]; other site
223283007519	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283007520	catalytic residue [active]
223283007521	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
223283007522	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283007523	Transposase domain (DUF772); Region: DUF772; pfam05598
223283007524	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283007525	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283007526	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
223283007527	Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxy acid dehydrogenase family; Region: formate_dh_like; cd05198
223283007528	ligand binding site [chemical binding]; other site
223283007529	NAD binding site [chemical binding]; other site
223283007530	dimerization interface [polypeptide binding]; other site
223283007531	catalytic site [active]
223283007532	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
223283007533	FAD binding domain; Region: FAD_binding_4; pfam01565
223283007534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283007535	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283007536	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283007537	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283007538	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283007539	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283007540	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283007541	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
223283007542	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
223283007543	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
223283007544	active site
223283007545	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
223283007546	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
223283007547	active site
223283007548	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283007549	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
223283007550	putative active site [active]
223283007551	heme pocket [chemical binding]; other site
223283007552	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283007553	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
223283007554	putative active site [active]
223283007555	heme pocket [chemical binding]; other site
223283007556	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283007557	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
223283007558	putative active site [active]
223283007559	heme pocket [chemical binding]; other site
223283007560	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283007561	putative active site [active]
223283007562	heme pocket [chemical binding]; other site
223283007563	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283007564	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283007565	dimer interface [polypeptide binding]; other site
223283007566	putative CheW interface [polypeptide binding]; other site
223283007567	CheW-like domain; Region: CheW; pfam01584
223283007568	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
223283007569	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
223283007570	putative acetyltransferase; Provisional; Region: PRK03624
223283007571	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283007572	Coenzyme A binding pocket [chemical binding]; other site
223283007573	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
223283007574	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283007575	LysR family transcriptional regulator; Provisional; Region: PRK14997
223283007576	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
223283007577	putative effector binding pocket; other site
223283007578	dimerization interface [polypeptide binding]; other site
223283007579	Cache domain; Region: Cache_1; pfam02743
223283007580	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283007581	dimerization interface [polypeptide binding]; other site
223283007582	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283007583	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283007584	dimer interface [polypeptide binding]; other site
223283007585	putative CheW interface [polypeptide binding]; other site
223283007586	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
223283007587	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
223283007588	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
223283007589	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
223283007590	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
223283007591	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
223283007592	hydroxyglutarate oxidase; Provisional; Region: PRK11728
223283007593	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194
223283007594	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
223283007595	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
223283007596	homodimer interface [polypeptide binding]; other site
223283007597	NADP binding site [chemical binding]; other site
223283007598	substrate binding site [chemical binding]; other site
223283007599	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
223283007600	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
223283007601	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
223283007602	putative active site [active]
223283007603	putative substrate binding site [chemical binding]; other site
223283007604	putative cosubstrate binding site; other site
223283007605	catalytic site [active]
223283007606	GAD-like domain; Region: GAD-like; pfam08887
223283007607	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
223283007608	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283007609	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283007610	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283007611	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283007612	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283007613	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283007614	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283007615	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283007616	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283007617	N-terminal plug; other site
223283007618	ligand-binding site [chemical binding]; other site
223283007619	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
223283007620	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
223283007621	Transposase; Region: DEDD_Tnp_IS110; pfam01548
223283007622	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
223283007623	Predicted amidohydrolase [General function prediction only]; Region: COG0388
223283007624	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
223283007625	active site
223283007626	catalytic triad [active]
223283007627	dimer interface [polypeptide binding]; other site
223283007628	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283007629	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283007630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283007631	putative substrate translocation pore; other site
223283007632	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
223283007633	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
223283007634	Strictosidine synthase; Region: Str_synth; pfam03088
223283007635	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
223283007636	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
223283007637	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283007638	dimerization interface [polypeptide binding]; other site
223283007639	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283007640	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283007641	dimer interface [polypeptide binding]; other site
223283007642	putative CheW interface [polypeptide binding]; other site
223283007643	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
223283007644	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
223283007645	putative ligand binding site [chemical binding]; other site
223283007646	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
223283007647	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
223283007648	active site
223283007649	substrate binding site [chemical binding]; other site
223283007650	Mg2+ binding site [ion binding]; other site
223283007651	HAMP domain; Region: HAMP; pfam00672
223283007652	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283007653	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283007654	dimer interface [polypeptide binding]; other site
223283007655	putative CheW interface [polypeptide binding]; other site
223283007656	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
223283007657	homotrimer interaction site [polypeptide binding]; other site
223283007658	putative active site [active]
223283007659	DNA topoisomerase III; Provisional; Region: PRK07726
223283007660	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
223283007661	active site
223283007662	putative interdomain interaction site [polypeptide binding]; other site
223283007663	putative metal-binding site [ion binding]; other site
223283007664	putative nucleotide binding site [chemical binding]; other site
223283007665	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
223283007666	domain I; other site
223283007667	DNA binding groove [nucleotide binding]
223283007668	phosphate binding site [ion binding]; other site
223283007669	domain II; other site
223283007670	domain III; other site
223283007671	nucleotide binding site [chemical binding]; other site
223283007672	catalytic site [active]
223283007673	domain IV; other site
223283007674	HDOD domain; Region: HDOD; pfam08668
223283007675	HD domain; Region: HD; pfam01966
223283007676	Cache domain; Region: Cache_1; pfam02743
223283007677	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283007678	dimerization interface [polypeptide binding]; other site
223283007679	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283007680	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283007681	dimer interface [polypeptide binding]; other site
223283007682	putative CheW interface [polypeptide binding]; other site
223283007683	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
223283007684	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
223283007685	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
223283007686	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
223283007687	TolR protein; Region: tolR; TIGR02801
223283007688	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
223283007689	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283007690	N-terminal plug; other site
223283007691	ligand-binding site [chemical binding]; other site
223283007692	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
223283007693	Transposase; Region: DEDD_Tnp_IS110; pfam01548
223283007694	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
223283007695	NMT1-like family; Region: NMT1_2; pfam13379
223283007696	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
223283007697	aldolase II superfamily protein; Provisional; Region: PRK07044
223283007698	active site
223283007699	intersubunit interface [polypeptide binding]; other site
223283007700	Zn2+ binding site [ion binding]; other site
223283007701	glutaminase; Provisional; Region: PRK00971
223283007702	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
223283007703	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
223283007704	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
223283007705	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
223283007706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283007707	Walker A/P-loop; other site
223283007708	ATP binding site [chemical binding]; other site
223283007709	Q-loop/lid; other site
223283007710	ABC transporter signature motif; other site
223283007711	Walker B; other site
223283007712	D-loop; other site
223283007713	H-loop/switch region; other site
223283007714	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
223283007715	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
223283007716	active site
223283007717	catalytic tetrad [active]
223283007718	glucose-1-dehydrogenase; Provisional; Region: PRK08936
223283007719	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
223283007720	NAD binding site [chemical binding]; other site
223283007721	homodimer interface [polypeptide binding]; other site
223283007722	active site
223283007723	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
223283007724	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
223283007725	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283007726	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283007727	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
223283007728	putative effector binding pocket; other site
223283007729	putative dimerization interface [polypeptide binding]; other site
223283007730	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
223283007731	benzoate transport; Region: 2A0115; TIGR00895
223283007732	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283007733	putative substrate translocation pore; other site
223283007734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283007735	manganese transport protein MntH; Reviewed; Region: PRK00701
223283007736	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
223283007737	benzoate transport; Region: 2A0115; TIGR00895
223283007738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283007739	putative substrate translocation pore; other site
223283007740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283007741	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
223283007742	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
223283007743	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283007744	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
223283007745	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283007746	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
223283007747	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
223283007748	NmrA-like family; Region: NmrA; pfam05368
223283007749	NADP binding site [chemical binding]; other site
223283007750	Predicted transcriptional regulators [Transcription]; Region: COG1733
223283007751	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
223283007752	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
223283007753	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
223283007754	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
223283007755	pyruvate dehydrogenase; Provisional; Region: PRK09124
223283007756	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
223283007757	PYR/PP interface [polypeptide binding]; other site
223283007758	dimer interface [polypeptide binding]; other site
223283007759	tetramer interface [polypeptide binding]; other site
223283007760	TPP binding site [chemical binding]; other site
223283007761	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
223283007762	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
223283007763	TPP-binding site [chemical binding]; other site
223283007764	Nitrate and nitrite sensing; Region: NIT; pfam08376
223283007765	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283007766	HAMP domain; Region: HAMP; pfam00672
223283007767	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283007768	dimer interface [polypeptide binding]; other site
223283007769	putative CheW interface [polypeptide binding]; other site
223283007770	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
223283007771	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
223283007772	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283007773	FeS/SAM binding site; other site
223283007774	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
223283007775	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
223283007776	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
223283007777	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
223283007778	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
223283007779	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
223283007780	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
223283007781	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
223283007782	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
223283007783	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
223283007784	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283007785	dimer interface [polypeptide binding]; other site
223283007786	conserved gate region; other site
223283007787	putative PBP binding loops; other site
223283007788	ABC-ATPase subunit interface; other site
223283007789	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
223283007790	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283007791	dimer interface [polypeptide binding]; other site
223283007792	conserved gate region; other site
223283007793	putative PBP binding loops; other site
223283007794	ABC-ATPase subunit interface; other site
223283007795	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
223283007796	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283007797	Walker A/P-loop; other site
223283007798	ATP binding site [chemical binding]; other site
223283007799	Q-loop/lid; other site
223283007800	ABC transporter signature motif; other site
223283007801	Walker B; other site
223283007802	D-loop; other site
223283007803	H-loop/switch region; other site
223283007804	TOBE domain; Region: TOBE_2; pfam08402
223283007805	Transcriptional regulator [Transcription]; Region: IclR; COG1414
223283007806	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
223283007807	Bacterial transcriptional regulator; Region: IclR; pfam01614
223283007808	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283007809	dimerization interface [polypeptide binding]; other site
223283007810	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283007811	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283007812	dimer interface [polypeptide binding]; other site
223283007813	putative CheW interface [polypeptide binding]; other site
223283007814	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
223283007815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283007816	S-adenosylmethionine binding site [chemical binding]; other site
223283007817	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
223283007818	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
223283007819	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
223283007820	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
223283007821	FOG: CBS domain [General function prediction only]; Region: COG0517
223283007822	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
223283007823	Transporter associated domain; Region: CorC_HlyC; smart01091
223283007824	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
223283007825	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
223283007826	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
223283007827	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
223283007828	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
223283007829	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
223283007830	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
223283007831	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
223283007832	Transposase domain (DUF772); Region: DUF772; pfam05598
223283007833	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283007834	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283007835	Protein of unknown function (DUF770); Region: DUF770; pfam05591
223283007836	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
223283007837	Protein of unknown function (DUF877); Region: DUF877; pfam05943
223283007838	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
223283007839	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
223283007840	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
223283007841	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
223283007842	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
223283007843	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283007844	Walker A motif; other site
223283007845	ATP binding site [chemical binding]; other site
223283007846	Walker B motif; other site
223283007847	arginine finger; other site
223283007848	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283007849	Walker A motif; other site
223283007850	ATP binding site [chemical binding]; other site
223283007851	Walker B motif; other site
223283007852	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
223283007853	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
223283007854	GAF domain; Region: GAF; cl17456
223283007855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283007856	Walker A motif; other site
223283007857	ATP binding site [chemical binding]; other site
223283007858	Walker B motif; other site
223283007859	arginine finger; other site
223283007860	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283007861	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
223283007862	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
223283007863	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
223283007864	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
223283007865	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
223283007866	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
223283007867	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
223283007868	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
223283007869	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
223283007870	Walker A/P-loop; other site
223283007871	ATP binding site [chemical binding]; other site
223283007872	Q-loop/lid; other site
223283007873	ABC transporter signature motif; other site
223283007874	Walker B; other site
223283007875	D-loop; other site
223283007876	H-loop/switch region; other site
223283007877	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
223283007878	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
223283007879	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283007880	dimer interface [polypeptide binding]; other site
223283007881	conserved gate region; other site
223283007882	ABC-ATPase subunit interface; other site
223283007883	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
223283007884	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283007885	DNA-binding site [nucleotide binding]; DNA binding site
223283007886	UTRA domain; Region: UTRA; pfam07702
223283007887	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
223283007888	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
223283007889	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
223283007890	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
223283007891	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
223283007892	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283007893	Walker A/P-loop; other site
223283007894	ATP binding site [chemical binding]; other site
223283007895	Q-loop/lid; other site
223283007896	ABC transporter signature motif; other site
223283007897	Walker B; other site
223283007898	D-loop; other site
223283007899	H-loop/switch region; other site
223283007900	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283007901	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
223283007902	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283007903	Walker A/P-loop; other site
223283007904	ATP binding site [chemical binding]; other site
223283007905	Q-loop/lid; other site
223283007906	ABC transporter signature motif; other site
223283007907	Walker B; other site
223283007908	D-loop; other site
223283007909	H-loop/switch region; other site
223283007910	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
223283007911	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
223283007912	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
223283007913	active site
223283007914	phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Region: phosphon_PhnN; TIGR02322
223283007915	AAA domain; Region: AAA_18; pfam13238
223283007916	active site
223283007917	putative hydrolase; Provisional; Region: PRK02113
223283007918	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
223283007919	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
223283007920	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
223283007921	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
223283007922	Trp docking motif [polypeptide binding]; other site
223283007923	putative active site [active]
223283007924	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
223283007925	Amidase; Region: Amidase; pfam01425
223283007926	hypothetical protein; Provisional; Region: PRK07338
223283007927	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
223283007928	metal binding site [ion binding]; metal-binding site
223283007929	dimer interface [polypeptide binding]; other site
223283007930	hypothetical protein; Provisional; Region: PRK07079
223283007931	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
223283007932	metal binding site [ion binding]; metal-binding site
223283007933	putative dimer interface [polypeptide binding]; other site
223283007934	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
223283007935	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283007936	Walker A/P-loop; other site
223283007937	ATP binding site [chemical binding]; other site
223283007938	Q-loop/lid; other site
223283007939	ABC transporter signature motif; other site
223283007940	Walker B; other site
223283007941	D-loop; other site
223283007942	H-loop/switch region; other site
223283007943	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283007944	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
223283007945	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283007946	Walker A/P-loop; other site
223283007947	ATP binding site [chemical binding]; other site
223283007948	Q-loop/lid; other site
223283007949	ABC transporter signature motif; other site
223283007950	Walker B; other site
223283007951	D-loop; other site
223283007952	H-loop/switch region; other site
223283007953	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283007954	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
223283007955	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
223283007956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283007957	dimer interface [polypeptide binding]; other site
223283007958	conserved gate region; other site
223283007959	putative PBP binding loops; other site
223283007960	ABC-ATPase subunit interface; other site
223283007961	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
223283007962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283007963	dimer interface [polypeptide binding]; other site
223283007964	conserved gate region; other site
223283007965	putative PBP binding loops; other site
223283007966	ABC-ATPase subunit interface; other site
223283007967	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515
223283007968	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
223283007969	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283007970	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283007971	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283007972	dimerization interface [polypeptide binding]; other site
223283007973	putative GTP cyclohydrolase; Provisional; Region: PRK13674
223283007974	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
223283007975	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
223283007976	trimer interface [polypeptide binding]; other site
223283007977	active site
223283007978	Predicted membrane protein [Function unknown]; Region: COG3503
223283007979	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
223283007980	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283007981	non-specific DNA binding site [nucleotide binding]; other site
223283007982	salt bridge; other site
223283007983	sequence-specific DNA binding site [nucleotide binding]; other site
223283007984	Cupin domain; Region: Cupin_2; pfam07883
223283007985	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
223283007986	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
223283007987	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
223283007988	putative active site [active]
223283007989	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
223283007990	domain_subunit interface; other site
223283007991	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
223283007992	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
223283007993	active site
223283007994	FMN binding site [chemical binding]; other site
223283007995	substrate binding site [chemical binding]; other site
223283007996	3Fe-4S cluster binding site [ion binding]; other site
223283007997	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
223283007998	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
223283007999	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
223283008000	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
223283008001	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
223283008002	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
223283008003	active site
223283008004	dimer interface [polypeptide binding]; other site
223283008005	non-prolyl cis peptide bond; other site
223283008006	insertion regions; other site
223283008007	Cache domain; Region: Cache_1; pfam02743
223283008008	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283008009	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283008010	metal binding site [ion binding]; metal-binding site
223283008011	active site
223283008012	I-site; other site
223283008013	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
223283008014	Protein export membrane protein; Region: SecD_SecF; cl14618
223283008015	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
223283008016	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283008017	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283008018	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283008019	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
223283008020	salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054
223283008021	chorismate binding enzyme; Region: Chorismate_bind; cl10555
223283008022	isochorismate-pyruvate lyase; Reviewed; Region: PRK07075
223283008023	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
223283008024	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
223283008025	acyl-activating enzyme (AAE) consensus motif; other site
223283008026	active site
223283008027	AMP binding site [chemical binding]; other site
223283008028	substrate binding site [chemical binding]; other site
223283008029	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
223283008030	Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693
223283008031	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
223283008032	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
223283008033	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
223283008034	active site
223283008035	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
223283008036	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
223283008037	Methyltransferase domain; Region: Methyltransf_12; pfam08242
223283008038	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
223283008039	KR domain; Region: KR; pfam08659
223283008040	NADP binding site [chemical binding]; other site
223283008041	active site
223283008042	Condensation domain; Region: Condensation; pfam00668
223283008043	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283008044	Nonribosomal peptide synthase; Region: NRPS; pfam08415
223283008045	Methyltransferase domain; Region: Methyltransf_12; pfam08242
223283008046	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008047	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
223283008048	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283008049	putative substrate translocation pore; other site
223283008050	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
223283008051	Condensation domain; Region: Condensation; pfam00668
223283008052	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283008053	Nonribosomal peptide synthase; Region: NRPS; pfam08415
223283008054	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
223283008055	acyl-activating enzyme (AAE) consensus motif; other site
223283008056	AMP binding site [chemical binding]; other site
223283008057	Methyltransferase domain; Region: Methyltransf_12; pfam08242
223283008058	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
223283008059	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008060	Condensation domain; Region: Condensation; pfam00668
223283008061	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283008062	Nonribosomal peptide synthase; Region: NRPS; pfam08415
223283008063	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008064	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
223283008065	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
223283008066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283008067	Walker A/P-loop; other site
223283008068	ATP binding site [chemical binding]; other site
223283008069	Q-loop/lid; other site
223283008070	ABC transporter signature motif; other site
223283008071	Walker B; other site
223283008072	D-loop; other site
223283008073	H-loop/switch region; other site
223283008074	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
223283008075	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
223283008076	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283008077	Walker A/P-loop; other site
223283008078	ATP binding site [chemical binding]; other site
223283008079	Q-loop/lid; other site
223283008080	ABC transporter signature motif; other site
223283008081	Walker B; other site
223283008082	D-loop; other site
223283008083	H-loop/switch region; other site
223283008084	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283008085	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283008086	N-terminal plug; other site
223283008087	ligand-binding site [chemical binding]; other site
223283008088	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
223283008089	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283008090	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
223283008091	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283008092	N-terminal plug; other site
223283008093	ligand-binding site [chemical binding]; other site
223283008094	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
223283008095	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
223283008096	Cu(I) binding site [ion binding]; other site
223283008097	Protein of unknown function (DUF461); Region: DUF461; pfam04314
223283008098	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
223283008099	active site
223283008100	metal binding site [ion binding]; metal-binding site
223283008101	homotetramer interface [polypeptide binding]; other site
223283008102	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
223283008103	active site
223283008104	motif 2; other site
223283008105	putative acetyltransferase YhhY; Provisional; Region: PRK10140
223283008106	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283008107	Coenzyme A binding pocket [chemical binding]; other site
223283008108	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
223283008109	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
223283008110	GAF domain; Region: GAF; pfam01590
223283008111	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283008112	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283008113	dimerization interface [polypeptide binding]; other site
223283008114	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283008115	dimer interface [polypeptide binding]; other site
223283008116	putative CheW interface [polypeptide binding]; other site
223283008117	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283008118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283008119	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
223283008120	putative effector binding pocket; other site
223283008121	putative dimerization interface [polypeptide binding]; other site
223283008122	acetylornithine aminotransferase; Provisional; Region: PRK02627
223283008123	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283008124	inhibitor-cofactor binding pocket; inhibition site
223283008125	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283008126	catalytic residue [active]
223283008127	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
223283008128	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
223283008129	FOG: CBS domain [General function prediction only]; Region: COG0517
223283008130	DNA polymerase II; Reviewed; Region: PRK05762
223283008131	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
223283008132	active site
223283008133	catalytic site [active]
223283008134	substrate binding site [chemical binding]; other site
223283008135	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
223283008136	active site
223283008137	metal-binding site
223283008138	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
223283008139	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
223283008140	NAD+ binding site [chemical binding]; other site
223283008141	substrate binding site [chemical binding]; other site
223283008142	Zn binding site [ion binding]; other site
223283008143	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
223283008144	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
223283008145	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283008146	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283008147	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
223283008148	putative dimerization interface [polypeptide binding]; other site
223283008149	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283008150	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283008151	substrate binding pocket [chemical binding]; other site
223283008152	membrane-bound complex binding site; other site
223283008153	hinge residues; other site
223283008154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008155	dimer interface [polypeptide binding]; other site
223283008156	conserved gate region; other site
223283008157	putative PBP binding loops; other site
223283008158	ABC-ATPase subunit interface; other site
223283008159	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283008160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008161	dimer interface [polypeptide binding]; other site
223283008162	conserved gate region; other site
223283008163	putative PBP binding loops; other site
223283008164	ABC-ATPase subunit interface; other site
223283008165	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
223283008166	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283008167	Walker A/P-loop; other site
223283008168	ATP binding site [chemical binding]; other site
223283008169	Q-loop/lid; other site
223283008170	ABC transporter signature motif; other site
223283008171	Walker B; other site
223283008172	D-loop; other site
223283008173	H-loop/switch region; other site
223283008174	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
223283008175	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
223283008176	active site residue [active]
223283008177	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
223283008178	active site residue [active]
223283008179	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
223283008180	active site residue [active]
223283008181	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
223283008182	active site residue [active]
223283008183	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
223283008184	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
223283008185	homodimer interface [polypeptide binding]; other site
223283008186	substrate-cofactor binding pocket; other site
223283008187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283008188	catalytic residue [active]
223283008189	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
223283008190	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
223283008191	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
223283008192	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
223283008193	ABC-ATPase subunit  interface; other site
223283008194	dimer interface [polypeptide binding]; other site
223283008195	putative PBP binding regions; other site
223283008196	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
223283008197	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
223283008198	metal binding site [ion binding]; metal-binding site
223283008199	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
223283008200	active site
223283008201	catalytic residues [active]
223283008202	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
223283008203	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
223283008204	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
223283008205	ligand binding site [chemical binding]; other site
223283008206	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
223283008207	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
223283008208	Walker A/P-loop; other site
223283008209	ATP binding site [chemical binding]; other site
223283008210	Q-loop/lid; other site
223283008211	ABC transporter signature motif; other site
223283008212	Walker B; other site
223283008213	D-loop; other site
223283008214	H-loop/switch region; other site
223283008215	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
223283008216	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
223283008217	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283008218	TM-ABC transporter signature motif; other site
223283008219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283008220	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283008221	dimer interface [polypeptide binding]; other site
223283008222	phosphorylation site [posttranslational modification]
223283008223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283008224	ATP binding site [chemical binding]; other site
223283008225	Mg2+ binding site [ion binding]; other site
223283008226	G-X-G motif; other site
223283008227	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
223283008228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283008229	active site
223283008230	phosphorylation site [posttranslational modification]
223283008231	intermolecular recognition site; other site
223283008232	dimerization interface [polypeptide binding]; other site
223283008233	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283008234	DNA binding site [nucleotide binding]
223283008235	MltA-interacting protein MipA; Region: MipA; cl01504
223283008236	hypothetical protein; Provisional; Region: PRK06184
223283008237	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
223283008238	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
223283008239	dimer interface [polypeptide binding]; other site
223283008240	tetracycline repressor protein TetR; Provisional; Region: PRK13756
223283008241	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283008242	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
223283008243	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
223283008244	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
223283008245	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
223283008246	Response regulator receiver domain; Region: Response_reg; pfam00072
223283008247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283008248	active site
223283008249	phosphorylation site [posttranslational modification]
223283008250	intermolecular recognition site; other site
223283008251	dimerization interface [polypeptide binding]; other site
223283008252	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
223283008253	GAF domain; Region: GAF; pfam01590
223283008254	Phytochrome region; Region: PHY; pfam00360
223283008255	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283008256	dimer interface [polypeptide binding]; other site
223283008257	phosphorylation site [posttranslational modification]
223283008258	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283008259	ATP binding site [chemical binding]; other site
223283008260	Mg2+ binding site [ion binding]; other site
223283008261	G-X-G motif; other site
223283008262	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
223283008263	HWE histidine kinase; Region: HWE_HK; pfam07536
223283008264	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
223283008265	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
223283008266	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
223283008267	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
223283008268	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
223283008269	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
223283008270	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
223283008271	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
223283008272	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
223283008273	XdhC Rossmann domain; Region: XdhC_C; pfam13478
223283008274	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
223283008275	Ligand binding site; other site
223283008276	metal-binding site
223283008277	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
223283008278	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
223283008279	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
223283008280	NAD(P) binding site [chemical binding]; other site
223283008281	catalytic residues [active]
223283008282	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283008283	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283008284	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
223283008285	putative dimerization interface [polypeptide binding]; other site
223283008286	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
223283008287	tartrate dehydrogenase; Region: TTC; TIGR02089
223283008288	transcriptional activator TtdR; Provisional; Region: PRK09801
223283008289	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283008290	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
223283008291	putative effector binding pocket; other site
223283008292	putative dimerization interface [polypeptide binding]; other site
223283008293	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
223283008294	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283008295	Walker A/P-loop; other site
223283008296	ATP binding site [chemical binding]; other site
223283008297	Q-loop/lid; other site
223283008298	ABC transporter signature motif; other site
223283008299	Walker B; other site
223283008300	D-loop; other site
223283008301	H-loop/switch region; other site
223283008302	TOBE domain; Region: TOBE_2; pfam08402
223283008303	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
223283008304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008305	dimer interface [polypeptide binding]; other site
223283008306	conserved gate region; other site
223283008307	putative PBP binding loops; other site
223283008308	ABC-ATPase subunit interface; other site
223283008309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008310	dimer interface [polypeptide binding]; other site
223283008311	conserved gate region; other site
223283008312	putative PBP binding loops; other site
223283008313	ABC-ATPase subunit interface; other site
223283008314	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
223283008315	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
223283008316	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485
223283008317	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
223283008318	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
223283008319	dimerization interface [polypeptide binding]; other site
223283008320	active site
223283008321	Uncharacterized conserved protein [Function unknown]; Region: COG5470
223283008322	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
223283008323	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
223283008324	nudix motif; other site
223283008325	Transcriptional regulators [Transcription]; Region: GntR; COG1802
223283008326	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283008327	DNA-binding site [nucleotide binding]; DNA binding site
223283008328	FCD domain; Region: FCD; pfam07729
223283008329	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
223283008330	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
223283008331	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
223283008332	NAD(P) binding site [chemical binding]; other site
223283008333	catalytic residues [active]
223283008334	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
223283008335	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
223283008336	Amino acid synthesis; Region: AA_synth; pfam06684
223283008337	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
223283008338	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
223283008339	NAD binding site [chemical binding]; other site
223283008340	catalytic Zn binding site [ion binding]; other site
223283008341	structural Zn binding site [ion binding]; other site
223283008342	short chain dehydrogenase; Provisional; Region: PRK06701
223283008343	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
223283008344	NAD binding site [chemical binding]; other site
223283008345	metal binding site [ion binding]; metal-binding site
223283008346	active site
223283008347	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
223283008348	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283008349	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283008350	catalytic residue [active]
223283008351	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
223283008352	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
223283008353	tetramerization interface [polypeptide binding]; other site
223283008354	NAD(P) binding site [chemical binding]; other site
223283008355	catalytic residues [active]
223283008356	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
223283008357	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
223283008358	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
223283008359	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
223283008360	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
223283008361	shikimate binding site; other site
223283008362	NAD(P) binding site [chemical binding]; other site
223283008363	Protein of unknown function, DUF480; Region: DUF480; cl01209
223283008364	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
223283008365	putative arabinose transporter; Provisional; Region: PRK03545
223283008366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283008367	putative substrate translocation pore; other site
223283008368	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
223283008369	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283008370	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
223283008371	putative dimerization interface [polypeptide binding]; other site
223283008372	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
223283008373	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
223283008374	putative active site [active]
223283008375	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
223283008376	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
223283008377	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
223283008378	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
223283008379	NAD(P) binding site [chemical binding]; other site
223283008380	active site
223283008381	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
223283008382	nudix motif; other site
223283008383	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
223283008384	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
223283008385	putative NAD(P) binding site [chemical binding]; other site
223283008386	putative substrate binding site [chemical binding]; other site
223283008387	catalytic Zn binding site [ion binding]; other site
223283008388	structural Zn binding site [ion binding]; other site
223283008389	dimer interface [polypeptide binding]; other site
223283008390	GAF domain; Region: GAF; cl17456
223283008391	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
223283008392	GAF domain; Region: GAF_3; pfam13492
223283008393	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283008394	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283008395	metal binding site [ion binding]; metal-binding site
223283008396	active site
223283008397	I-site; other site
223283008398	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283008399	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
223283008400	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
223283008401	putative substrate binding site [chemical binding]; other site
223283008402	putative ATP binding site [chemical binding]; other site
223283008403	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
223283008404	N- and C-terminal domain interface [polypeptide binding]; other site
223283008405	D-xylulose kinase; Region: XylB; TIGR01312
223283008406	active site
223283008407	MgATP binding site [chemical binding]; other site
223283008408	catalytic site [active]
223283008409	metal binding site [ion binding]; metal-binding site
223283008410	xylulose binding site [chemical binding]; other site
223283008411	putative homodimer interface [polypeptide binding]; other site
223283008412	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
223283008413	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
223283008414	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
223283008415	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
223283008416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008417	dimer interface [polypeptide binding]; other site
223283008418	conserved gate region; other site
223283008419	ABC-ATPase subunit interface; other site
223283008420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008421	dimer interface [polypeptide binding]; other site
223283008422	conserved gate region; other site
223283008423	putative PBP binding loops; other site
223283008424	ABC-ATPase subunit interface; other site
223283008425	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
223283008426	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
223283008427	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
223283008428	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
223283008429	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283008430	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283008431	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
223283008432	active site
223283008433	SAM binding site [chemical binding]; other site
223283008434	homodimer interface [polypeptide binding]; other site
223283008435	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
223283008436	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283008437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283008438	active site
223283008439	phosphorylation site [posttranslational modification]
223283008440	intermolecular recognition site; other site
223283008441	dimerization interface [polypeptide binding]; other site
223283008442	CHASE3 domain; Region: CHASE3; pfam05227
223283008443	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
223283008444	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
223283008445	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283008446	dimer interface [polypeptide binding]; other site
223283008447	phosphorylation site [posttranslational modification]
223283008448	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283008449	ATP binding site [chemical binding]; other site
223283008450	Mg2+ binding site [ion binding]; other site
223283008451	G-X-G motif; other site
223283008452	Response regulator receiver domain; Region: Response_reg; pfam00072
223283008453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283008454	active site
223283008455	phosphorylation site [posttranslational modification]
223283008456	intermolecular recognition site; other site
223283008457	dimerization interface [polypeptide binding]; other site
223283008458	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283008459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283008460	active site
223283008461	phosphorylation site [posttranslational modification]
223283008462	intermolecular recognition site; other site
223283008463	Response regulator receiver domain; Region: Response_reg; pfam00072
223283008464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283008465	active site
223283008466	phosphorylation site [posttranslational modification]
223283008467	intermolecular recognition site; other site
223283008468	dimerization interface [polypeptide binding]; other site
223283008469	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
223283008470	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
223283008471	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
223283008472	CheB methylesterase; Region: CheB_methylest; pfam01339
223283008473	Response regulator receiver domain; Region: Response_reg; pfam00072
223283008474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283008475	active site
223283008476	phosphorylation site [posttranslational modification]
223283008477	intermolecular recognition site; other site
223283008478	dimerization interface [polypeptide binding]; other site
223283008479	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283008480	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283008481	dimer interface [polypeptide binding]; other site
223283008482	phosphorylation site [posttranslational modification]
223283008483	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283008484	ATP binding site [chemical binding]; other site
223283008485	Mg2+ binding site [ion binding]; other site
223283008486	G-X-G motif; other site
223283008487	Response regulator receiver domain; Region: Response_reg; pfam00072
223283008488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283008489	active site
223283008490	phosphorylation site [posttranslational modification]
223283008491	intermolecular recognition site; other site
223283008492	dimerization interface [polypeptide binding]; other site
223283008493	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283008494	heme pocket [chemical binding]; other site
223283008495	putative active site [active]
223283008496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283008497	dimer interface [polypeptide binding]; other site
223283008498	phosphorylation site [posttranslational modification]
223283008499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283008500	ATP binding site [chemical binding]; other site
223283008501	G-X-G motif; other site
223283008502	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283008503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283008504	active site
223283008505	phosphorylation site [posttranslational modification]
223283008506	intermolecular recognition site; other site
223283008507	dimerization interface [polypeptide binding]; other site
223283008508	circadian clock protein KaiC; Reviewed; Region: PRK09302
223283008509	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
223283008510	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
223283008511	Walker A motif; other site
223283008512	Walker A motif; other site
223283008513	ATP binding site [chemical binding]; other site
223283008514	Walker B motif; other site
223283008515	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
223283008516	Walker A motif; other site
223283008517	ATP binding site [chemical binding]; other site
223283008518	Walker B motif; other site
223283008519	enoyl-CoA hydratase; Provisional; Region: PRK06142
223283008520	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
223283008521	substrate binding site [chemical binding]; other site
223283008522	oxyanion hole (OAH) forming residues; other site
223283008523	trimer interface [polypeptide binding]; other site
223283008524	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
223283008525	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
223283008526	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
223283008527	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
223283008528	putative NADH binding site [chemical binding]; other site
223283008529	putative active site [active]
223283008530	nudix motif; other site
223283008531	putative metal binding site [ion binding]; other site
223283008532	hypothetical protein; Provisional; Region: PRK10621
223283008533	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
223283008534	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
223283008535	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
223283008536	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
223283008537	short chain dehydrogenase; Provisional; Region: PRK07035
223283008538	classical (c) SDRs; Region: SDR_c; cd05233
223283008539	NAD(P) binding site [chemical binding]; other site
223283008540	active site
223283008541	Phosphotransferase enzyme family; Region: APH; pfam01636
223283008542	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
223283008543	putative active site [active]
223283008544	putative substrate binding site [chemical binding]; other site
223283008545	ATP binding site [chemical binding]; other site
223283008546	SCP-2 sterol transfer family; Region: SCP2; pfam02036
223283008547	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
223283008548	catalytic core [active]
223283008549	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
223283008550	putative inner membrane peptidase; Provisional; Region: PRK11778
223283008551	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
223283008552	tandem repeat interface [polypeptide binding]; other site
223283008553	oligomer interface [polypeptide binding]; other site
223283008554	active site residues [active]
223283008555	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
223283008556	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
223283008557	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
223283008558	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
223283008559	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324
223283008560	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
223283008561	putative ligand binding site [chemical binding]; other site
223283008562	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
223283008563	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
223283008564	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
223283008565	substrate binding pocket [chemical binding]; other site
223283008566	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
223283008567	B12 binding site [chemical binding]; other site
223283008568	cobalt ligand [ion binding]; other site
223283008569	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
223283008570	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
223283008571	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
223283008572	active site
223283008573	substrate binding site [chemical binding]; other site
223283008574	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
223283008575	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
223283008576	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
223283008577	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
223283008578	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
223283008579	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
223283008580	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
223283008581	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
223283008582	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
223283008583	carboxyltransferase (CT) interaction site; other site
223283008584	biotinylation site [posttranslational modification]; other site
223283008585	gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674
223283008586	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
223283008587	substrate binding site [chemical binding]; other site
223283008588	oxyanion hole (OAH) forming residues; other site
223283008589	trimer interface [polypeptide binding]; other site
223283008590	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
223283008591	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
223283008592	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
223283008593	isovaleryl-CoA dehydrogenase; Region: PLN02519
223283008594	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
223283008595	substrate binding site [chemical binding]; other site
223283008596	FAD binding site [chemical binding]; other site
223283008597	catalytic base [active]
223283008598	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283008599	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283008600	DNA-binding interface [nucleotide binding]; DNA binding site
223283008601	Integrase core domain; Region: rve; pfam00665
223283008602	Integrase core domain; Region: rve_3; cl15866
223283008603	transposase/IS protein; Provisional; Region: PRK09183
223283008604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283008605	Walker A motif; other site
223283008606	ATP binding site [chemical binding]; other site
223283008607	Walker B motif; other site
223283008608	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
223283008609	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
223283008610	active site
223283008611	catalytic residues [active]
223283008612	metal binding site [ion binding]; metal-binding site
223283008613	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
223283008614	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
223283008615	DNA binding residues [nucleotide binding]
223283008616	putative dimer interface [polypeptide binding]; other site
223283008617	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
223283008618	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283008619	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
223283008620	substrate binding pocket [chemical binding]; other site
223283008621	dimerization interface [polypeptide binding]; other site
223283008622	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
223283008623	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
223283008624	FAD binding site [chemical binding]; other site
223283008625	substrate binding site [chemical binding]; other site
223283008626	catalytic base [active]
223283008627	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
223283008628	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
223283008629	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
223283008630	ligand binding site [chemical binding]; other site
223283008631	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
223283008632	putative catalytic site [active]
223283008633	putative phosphate binding site [ion binding]; other site
223283008634	active site
223283008635	metal binding site A [ion binding]; metal-binding site
223283008636	DNA binding site [nucleotide binding]
223283008637	putative AP binding site [nucleotide binding]; other site
223283008638	putative metal binding site B [ion binding]; other site
223283008639	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
223283008640	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
223283008641	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
223283008642	Surface antigen; Region: Bac_surface_Ag; pfam01103
223283008643	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
223283008644	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
223283008645	Family of unknown function (DUF490); Region: DUF490; pfam04357
223283008646	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283008647	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283008648	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
223283008649	putative effector binding pocket; other site
223283008650	putative dimerization interface [polypeptide binding]; other site
223283008651	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
223283008652	dimer interface [polypeptide binding]; other site
223283008653	catalytic triad [active]
223283008654	peroxidatic and resolving cysteines [active]
223283008655	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
223283008656	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
223283008657	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283008658	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
223283008659	Protein export membrane protein; Region: SecD_SecF; cl14618
223283008660	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
223283008661	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
223283008662	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
223283008663	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
223283008664	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283008665	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283008666	metal binding site [ion binding]; metal-binding site
223283008667	active site
223283008668	I-site; other site
223283008669	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283008670	short chain dehydrogenase; Provisional; Region: PRK06123
223283008671	classical (c) SDRs; Region: SDR_c; cd05233
223283008672	NAD(P) binding site [chemical binding]; other site
223283008673	active site
223283008674	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
223283008675	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
223283008676	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
223283008677	active site
223283008678	homodimer interface [polypeptide binding]; other site
223283008679	catalytic site [active]
223283008680	acceptor binding site [chemical binding]; other site
223283008681	trehalose synthase; Region: treS_nterm; TIGR02456
223283008682	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
223283008683	active site
223283008684	catalytic site [active]
223283008685	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
223283008686	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
223283008687	glycogen branching enzyme; Provisional; Region: PRK05402
223283008688	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
223283008689	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
223283008690	active site
223283008691	catalytic site [active]
223283008692	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
223283008693	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
223283008694	Autotransporter beta-domain; Region: Autotransporter; smart00869
223283008695	major facilitator superfamily transporter; Provisional; Region: PRK05122
223283008696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283008697	putative substrate translocation pore; other site
223283008698	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
223283008699	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
223283008700	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283008701	Walker A/P-loop; other site
223283008702	ATP binding site [chemical binding]; other site
223283008703	Q-loop/lid; other site
223283008704	ABC transporter signature motif; other site
223283008705	Walker B; other site
223283008706	D-loop; other site
223283008707	H-loop/switch region; other site
223283008708	ABC transporter; Region: ABC_tran_2; pfam12848
223283008709	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
223283008710	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
223283008711	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
223283008712	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
223283008713	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
223283008714	Coenzyme A binding pocket [chemical binding]; other site
223283008715	Protein of unknown function (DUF3830); Region: DUF3830; pfam12903
223283008716	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283008717	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283008718	substrate binding pocket [chemical binding]; other site
223283008719	membrane-bound complex binding site; other site
223283008720	hinge residues; other site
223283008721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008722	dimer interface [polypeptide binding]; other site
223283008723	conserved gate region; other site
223283008724	putative PBP binding loops; other site
223283008725	ABC-ATPase subunit interface; other site
223283008726	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283008727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008728	dimer interface [polypeptide binding]; other site
223283008729	conserved gate region; other site
223283008730	putative PBP binding loops; other site
223283008731	ABC-ATPase subunit interface; other site
223283008732	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
223283008733	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283008734	Walker A/P-loop; other site
223283008735	ATP binding site [chemical binding]; other site
223283008736	Q-loop/lid; other site
223283008737	ABC transporter signature motif; other site
223283008738	Walker B; other site
223283008739	D-loop; other site
223283008740	H-loop/switch region; other site
223283008741	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
223283008742	homotrimer interaction site [polypeptide binding]; other site
223283008743	putative active site [active]
223283008744	Transcriptional regulator [Transcription]; Region: IclR; COG1414
223283008745	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
223283008746	Bacterial transcriptional regulator; Region: IclR; pfam01614
223283008747	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
223283008748	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
223283008749	dimer interface [polypeptide binding]; other site
223283008750	active site
223283008751	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
223283008752	substrate binding site [chemical binding]; other site
223283008753	catalytic residue [active]
223283008754	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
223283008755	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
223283008756	substrate binding site [chemical binding]; other site
223283008757	ATP binding site [chemical binding]; other site
223283008758	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
223283008759	Family description; Region: UvrD_C_2; pfam13538
223283008760	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
223283008761	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
223283008762	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
223283008763	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
223283008764	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
223283008765	Walker A/P-loop; other site
223283008766	ATP binding site [chemical binding]; other site
223283008767	Q-loop/lid; other site
223283008768	ABC transporter signature motif; other site
223283008769	Walker B; other site
223283008770	D-loop; other site
223283008771	H-loop/switch region; other site
223283008772	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
223283008773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008774	dimer interface [polypeptide binding]; other site
223283008775	conserved gate region; other site
223283008776	putative PBP binding loops; other site
223283008777	ABC-ATPase subunit interface; other site
223283008778	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
223283008779	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283008780	membrane-bound complex binding site; other site
223283008781	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
223283008782	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
223283008783	active site
223283008784	catalytic tetrad [active]
223283008785	LexA repressor; Provisional; Region: PRK12423
223283008786	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
223283008787	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
223283008788	Catalytic site [active]
223283008789	Uncharacterized conserved protein [Function unknown]; Region: COG4544
223283008790	DNA Polymerase Y-family; Region: PolY_like; cd03468
223283008791	active site
223283008792	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
223283008793	DNA binding site [nucleotide binding]
223283008794	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
223283008795	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
223283008796	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
223283008797	putative active site [active]
223283008798	putative PHP Thumb interface [polypeptide binding]; other site
223283008799	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
223283008800	generic binding surface I; other site
223283008801	generic binding surface II; other site
223283008802	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
223283008803	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
223283008804	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
223283008805	oligomer interface [polypeptide binding]; other site
223283008806	Peptidase_C39 like family; Region: DUF3335; pfam11814
223283008807	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
223283008808	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
223283008809	NodB motif; other site
223283008810	active site
223283008811	catalytic site [active]
223283008812	metal binding site [ion binding]; metal-binding site
223283008813	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
223283008814	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
223283008815	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
223283008816	active site
223283008817	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283008818	metabolite-proton symporter; Region: 2A0106; TIGR00883
223283008819	putative substrate translocation pore; other site
223283008820	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
223283008821	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283008822	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
223283008823	dimerization interface [polypeptide binding]; other site
223283008824	substrate binding pocket [chemical binding]; other site
223283008825	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
223283008826	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283008827	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283008828	dimerization interface [polypeptide binding]; other site
223283008829	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
223283008830	FAD binding domain; Region: FAD_binding_4; pfam01565
223283008831	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
223283008832	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
223283008833	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
223283008834	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283008835	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283008836	metal binding site [ion binding]; metal-binding site
223283008837	active site
223283008838	I-site; other site
223283008839	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283008840	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283008841	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283008842	dimerization interface [polypeptide binding]; other site
223283008843	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
223283008844	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
223283008845	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
223283008846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008847	dimer interface [polypeptide binding]; other site
223283008848	conserved gate region; other site
223283008849	putative PBP binding loops; other site
223283008850	ABC-ATPase subunit interface; other site
223283008851	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
223283008852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283008853	dimer interface [polypeptide binding]; other site
223283008854	conserved gate region; other site
223283008855	putative PBP binding loops; other site
223283008856	ABC-ATPase subunit interface; other site
223283008857	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
223283008858	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283008859	Walker A/P-loop; other site
223283008860	ATP binding site [chemical binding]; other site
223283008861	Q-loop/lid; other site
223283008862	ABC transporter signature motif; other site
223283008863	Walker B; other site
223283008864	D-loop; other site
223283008865	H-loop/switch region; other site
223283008866	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283008867	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
223283008868	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
223283008869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
223283008870	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
223283008871	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
223283008872	Cupin domain; Region: Cupin_2; cl17218
223283008873	active site
223283008874	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
223283008875	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
223283008876	Fatty acid desaturase; Region: FA_desaturase; pfam00487
223283008877	putative di-iron ligands [ion binding]; other site
223283008878	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
223283008879	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
223283008880	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
223283008881	Fatty acid desaturase; Region: FA_desaturase; pfam00487
223283008882	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
223283008883	putative di-iron ligands [ion binding]; other site
223283008884	GH3 auxin-responsive promoter; Region: GH3; pfam03321
223283008885	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
223283008886	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
223283008887	[2Fe-2S] cluster binding site [ion binding]; other site
223283008888	DAK2 domain; Region: Dak2; pfam02734
223283008889	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
223283008890	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283008891	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283008892	DNA binding residues [nucleotide binding]
223283008893	dimerization interface [polypeptide binding]; other site
223283008894	Condensation domain; Region: Condensation; pfam00668
223283008895	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283008896	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
223283008897	acyl-activating enzyme (AAE) consensus motif; other site
223283008898	AMP binding site [chemical binding]; other site
223283008899	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008900	Condensation domain; Region: Condensation; pfam00668
223283008901	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283008902	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
223283008903	acyl-activating enzyme (AAE) consensus motif; other site
223283008904	AMP binding site [chemical binding]; other site
223283008905	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008906	Condensation domain; Region: Condensation; pfam00668
223283008907	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283008908	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
223283008909	acyl-activating enzyme (AAE) consensus motif; other site
223283008910	AMP binding site [chemical binding]; other site
223283008911	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008912	Condensation domain; Region: Condensation; pfam00668
223283008913	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283008914	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
223283008915	acyl-activating enzyme (AAE) consensus motif; other site
223283008916	AMP binding site [chemical binding]; other site
223283008917	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008918	Condensation domain; Region: Condensation; pfam00668
223283008919	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283008920	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283008921	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283008922	acyl-activating enzyme (AAE) consensus motif; other site
223283008923	AMP binding site [chemical binding]; other site
223283008924	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008925	Condensation domain; Region: Condensation; pfam00668
223283008926	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
223283008927	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
223283008928	acyl-activating enzyme (AAE) consensus motif; other site
223283008929	AMP binding site [chemical binding]; other site
223283008930	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008931	Condensation domain; Region: Condensation; pfam00668
223283008932	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283008933	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283008934	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283008935	acyl-activating enzyme (AAE) consensus motif; other site
223283008936	AMP binding site [chemical binding]; other site
223283008937	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008938	Condensation domain; Region: Condensation; pfam00668
223283008939	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283008940	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
223283008941	acyl-activating enzyme (AAE) consensus motif; other site
223283008942	AMP binding site [chemical binding]; other site
223283008943	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283008944	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
223283008945	macrolide transporter subunit MacA; Provisional; Region: PRK11578
223283008946	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
223283008947	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
223283008948	Walker A/P-loop; other site
223283008949	ATP binding site [chemical binding]; other site
223283008950	Q-loop/lid; other site
223283008951	ABC transporter signature motif; other site
223283008952	Walker B; other site
223283008953	D-loop; other site
223283008954	H-loop/switch region; other site
223283008955	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
223283008956	FtsX-like permease family; Region: FtsX; pfam02687
223283008957	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283008958	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
223283008959	DNA binding residues [nucleotide binding]
223283008960	dimerization interface [polypeptide binding]; other site
223283008961	Beta-lactamase; Region: Beta-lactamase; pfam00144
223283008962	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
223283008963	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
223283008964	Transposase domain (DUF772); Region: DUF772; pfam05598
223283008965	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283008966	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283008967	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283008968	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283008969	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283008970	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283008971	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283008972	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283008973	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283008974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283008975	Integrase core domain; Region: rve; pfam00665
223283008976	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283008977	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
223283008978	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
223283008979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283008980	Walker A motif; other site
223283008981	ATP binding site [chemical binding]; other site
223283008982	Walker B motif; other site
223283008983	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
223283008984	AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061
223283008985	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
223283008986	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283008987	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283008988	N-terminal plug; other site
223283008989	ligand-binding site [chemical binding]; other site
223283008990	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
223283008991	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
223283008992	conserved cys residue [active]
223283008993	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
223283008994	Protein of unknown function (DUF461); Region: DUF461; pfam04314
223283008995	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
223283008996	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
223283008997	Cu(I) binding site [ion binding]; other site
223283008998	AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061
223283008999	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283009000	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283009001	N-terminal plug; other site
223283009002	ligand-binding site [chemical binding]; other site
223283009003	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
223283009004	sequence-specific DNA binding site [nucleotide binding]; other site
223283009005	salt bridge; other site
223283009006	Vesicle coat trafficking protein Sec16 mid-region; Region: Sec16; pfam12932
223283009007	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
223283009008	Int/Topo IB signature motif; other site
223283009009	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
223283009010	Int/Topo IB signature motif; other site
223283009011	LabA_like proteins; Region: LabA_like/DUF88; cl10034
223283009012	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
223283009013	tellurite resistance protein terB; Region: terB; cd07176
223283009014	putative metal binding site [ion binding]; other site
223283009015	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283009016	nucleotide binding region [chemical binding]; other site
223283009017	ATP-binding site [chemical binding]; other site
223283009018	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
223283009019	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
223283009020	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
223283009021	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
223283009022	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
223283009023	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
223283009024	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283009025	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009026	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
223283009027	putative effector binding pocket; other site
223283009028	putative dimerization interface [polypeptide binding]; other site
223283009029	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
223283009030	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
223283009031	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
223283009032	TspO/MBR family; Region: TspO_MBR; pfam03073
223283009033	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
223283009034	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
223283009035	Virulence factor SrfB; Region: SrfB; pfam07520
223283009036	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
223283009037	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
223283009038	metal ion-dependent adhesion site (MIDAS); other site
223283009039	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
223283009040	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283009041	Walker A/P-loop; other site
223283009042	ATP binding site [chemical binding]; other site
223283009043	Q-loop/lid; other site
223283009044	ABC transporter signature motif; other site
223283009045	Walker B; other site
223283009046	D-loop; other site
223283009047	H-loop/switch region; other site
223283009048	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
223283009049	UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186
223283009050	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
223283009051	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
223283009052	metal ion-dependent adhesion site (MIDAS); other site
223283009053	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283009054	PAS domain; Region: PAS_9; pfam13426
223283009055	putative active site [active]
223283009056	heme pocket [chemical binding]; other site
223283009057	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283009058	PAS domain; Region: PAS_9; pfam13426
223283009059	putative active site [active]
223283009060	heme pocket [chemical binding]; other site
223283009061	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283009062	dimer interface [polypeptide binding]; other site
223283009063	putative CheW interface [polypeptide binding]; other site
223283009064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283009065	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283009066	Transposase domain (DUF772); Region: DUF772; pfam05598
223283009067	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283009068	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283009069	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
223283009070	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
223283009071	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
223283009072	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
223283009073	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
223283009074	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
223283009075	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
223283009076	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
223283009077	active site
223283009078	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
223283009079	Ricin-type beta-trefoil; Region: RICIN; smart00458
223283009080	putative sugar binding sites [chemical binding]; other site
223283009081	Q-X-W motif; other site
223283009082	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
223283009083	putative sugar binding sites [chemical binding]; other site
223283009084	Q-X-W motif; other site
223283009085	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
223283009086	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
223283009087	histidine kinase; Provisional; Region: PRK13557
223283009088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283009089	putative active site [active]
223283009090	heme pocket [chemical binding]; other site
223283009091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283009092	dimer interface [polypeptide binding]; other site
223283009093	phosphorylation site [posttranslational modification]
223283009094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283009095	ATP binding site [chemical binding]; other site
223283009096	Mg2+ binding site [ion binding]; other site
223283009097	G-X-G motif; other site
223283009098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283009099	active site
223283009100	phosphorylation site [posttranslational modification]
223283009101	intermolecular recognition site; other site
223283009102	dimerization interface [polypeptide binding]; other site
223283009103	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
223283009104	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
223283009105	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
223283009106	UDP-galactopyranose mutase; Region: GLF; pfam03275
223283009107	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
223283009108	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283009109	putative homodimer interface [polypeptide binding]; other site
223283009110	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
223283009111	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
223283009112	NAD binding site [chemical binding]; other site
223283009113	homodimer interface [polypeptide binding]; other site
223283009114	active site
223283009115	substrate binding site [chemical binding]; other site
223283009116	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
223283009117	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283009118	non-specific DNA binding site [nucleotide binding]; other site
223283009119	salt bridge; other site
223283009120	sequence-specific DNA binding site [nucleotide binding]; other site
223283009121	Cupin domain; Region: Cupin_2; pfam07883
223283009122	Peptidase C26; Region: Peptidase_C26; pfam07722
223283009123	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
223283009124	catalytic triad [active]
223283009125	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283009126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009127	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283009128	dimerization interface [polypeptide binding]; other site
223283009129	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
223283009130	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
223283009131	iron-sulfur cluster [ion binding]; other site
223283009132	[2Fe-2S] cluster binding site [ion binding]; other site
223283009133	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
223283009134	alpha subunit interface [polypeptide binding]; other site
223283009135	active site
223283009136	substrate binding site [chemical binding]; other site
223283009137	Fe binding site [ion binding]; other site
223283009138	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
223283009139	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
223283009140	FMN-binding pocket [chemical binding]; other site
223283009141	flavin binding motif; other site
223283009142	phosphate binding motif [ion binding]; other site
223283009143	beta-alpha-beta structure motif; other site
223283009144	NAD binding pocket [chemical binding]; other site
223283009145	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
223283009146	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
223283009147	catalytic loop [active]
223283009148	iron binding site [ion binding]; other site
223283009149	Transcriptional regulators [Transcription]; Region: GntR; COG1802
223283009150	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283009151	DNA-binding site [nucleotide binding]; DNA binding site
223283009152	FCD domain; Region: FCD; pfam07729
223283009153	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
223283009154	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283009155	metal binding site [ion binding]; metal-binding site
223283009156	active site
223283009157	I-site; other site
223283009158	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283009159	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
223283009160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009161	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
223283009162	putative dimerization interface [polypeptide binding]; other site
223283009163	putative substrate binding pocket [chemical binding]; other site
223283009164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283009165	D-galactonate transporter; Region: 2A0114; TIGR00893
223283009166	putative substrate translocation pore; other site
223283009167	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
223283009168	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
223283009169	active site
223283009170	tetramer interface [polypeptide binding]; other site
223283009171	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283009172	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283009173	substrate binding pocket [chemical binding]; other site
223283009174	membrane-bound complex binding site; other site
223283009175	hinge residues; other site
223283009176	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
223283009177	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283009178	Walker A/P-loop; other site
223283009179	ATP binding site [chemical binding]; other site
223283009180	Q-loop/lid; other site
223283009181	ABC transporter signature motif; other site
223283009182	Walker B; other site
223283009183	D-loop; other site
223283009184	H-loop/switch region; other site
223283009185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009186	dimer interface [polypeptide binding]; other site
223283009187	conserved gate region; other site
223283009188	putative PBP binding loops; other site
223283009189	ABC-ATPase subunit interface; other site
223283009190	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283009191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009192	dimer interface [polypeptide binding]; other site
223283009193	conserved gate region; other site
223283009194	putative PBP binding loops; other site
223283009195	ABC-ATPase subunit interface; other site
223283009196	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
223283009197	classical (c) SDRs; Region: SDR_c; cd05233
223283009198	NAD(P) binding site [chemical binding]; other site
223283009199	active site
223283009200	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
223283009201	putative active site [active]
223283009202	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
223283009203	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
223283009204	carboxyltransferase (CT) interaction site; other site
223283009205	biotinylation site [posttranslational modification]; other site
223283009206	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
223283009207	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
223283009208	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
223283009209	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
223283009210	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
223283009211	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
223283009212	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
223283009213	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
223283009214	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
223283009215	carboxyltransferase (CT) interaction site; other site
223283009216	biotinylation site [posttranslational modification]; other site
223283009217	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
223283009218	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009219	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
223283009220	putative dimerization interface [polypeptide binding]; other site
223283009221	aspartate aminotransferase; Provisional; Region: PRK06107
223283009222	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283009223	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283009224	homodimer interface [polypeptide binding]; other site
223283009225	catalytic residue [active]
223283009226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283009227	putative substrate translocation pore; other site
223283009228	outer membrane porin, OprD family; Region: OprD; pfam03573
223283009229	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
223283009230	HSP70 interaction site [polypeptide binding]; other site
223283009231	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
223283009232	Uncharacterized conserved protein [Function unknown]; Region: COG1359
223283009233	Major royal jelly protein; Region: MRJP; pfam03022
223283009234	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
223283009235	active site
223283009236	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
223283009237	catalytic tetrad [active]
223283009238	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283009239	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
223283009240	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
223283009241	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
223283009242	hypothetical protein; Provisional; Region: PRK12569
223283009243	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283009244	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009245	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
223283009246	putative substrate binding pocket [chemical binding]; other site
223283009247	dimerization interface [polypeptide binding]; other site
223283009248	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283009249	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283009250	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
223283009251	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
223283009252	dimer interface [polypeptide binding]; other site
223283009253	active site
223283009254	feruloyl-CoA synthase; Reviewed; Region: PRK08180
223283009255	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
223283009256	acyl-activating enzyme (AAE) consensus motif; other site
223283009257	putative AMP binding site [chemical binding]; other site
223283009258	putative active site [active]
223283009259	putative CoA binding site [chemical binding]; other site
223283009260	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
223283009261	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
223283009262	NAD(P) binding site [chemical binding]; other site
223283009263	catalytic residues [active]
223283009264	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
223283009265	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
223283009266	substrate binding site [chemical binding]; other site
223283009267	oxyanion hole (OAH) forming residues; other site
223283009268	trimer interface [polypeptide binding]; other site
223283009269	MarR family; Region: MarR_2; pfam12802
223283009270	outer membrane porin, OprD family; Region: OprD; pfam03573
223283009271	benzoate transport; Region: 2A0115; TIGR00895
223283009272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283009273	putative substrate translocation pore; other site
223283009274	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
223283009275	NAD(P) binding site [chemical binding]; other site
223283009276	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
223283009277	active site
223283009278	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
223283009279	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
223283009280	NAD(P) binding site [chemical binding]; other site
223283009281	catalytic residues [active]
223283009282	Activator of aromatic catabolism; Region: XylR_N; pfam06505
223283009283	V4R domain; Region: V4R; pfam02830
223283009284	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
223283009285	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283009286	Walker A motif; other site
223283009287	ATP binding site [chemical binding]; other site
223283009288	Walker B motif; other site
223283009289	arginine finger; other site
223283009290	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
223283009291	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283009292	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009293	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
223283009294	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
223283009295	conserved cys residue [active]
223283009296	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
223283009297	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
223283009298	conserved cys residue [active]
223283009299	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283009300	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
223283009301	Beta-lactamase; Region: Beta-lactamase; pfam00144
223283009302	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
223283009303	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
223283009304	putative active site [active]
223283009305	metal binding site [ion binding]; metal-binding site
223283009306	LysE type translocator; Region: LysE; cl00565
223283009307	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
223283009308	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
223283009309	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
223283009310	dimer interface [polypeptide binding]; other site
223283009311	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283009312	catalytic residue [active]
223283009313	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
223283009314	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
223283009315	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
223283009316	NAD(P) binding pocket [chemical binding]; other site
223283009317	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
223283009318	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283009319	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
223283009320	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
223283009321	ligand binding site [chemical binding]; other site
223283009322	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
223283009323	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
223283009324	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
223283009325	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
223283009326	active site
223283009327	nucleotide binding site [chemical binding]; other site
223283009328	HIGH motif; other site
223283009329	KMSKS motif; other site
223283009330	Cupin domain; Region: Cupin_2; pfam07883
223283009331	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
223283009332	active site
223283009333	DNA binding site [nucleotide binding]
223283009334	Int/Topo IB signature motif; other site
223283009335	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
223283009336	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
223283009337	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
223283009338	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
223283009339	NADP binding site [chemical binding]; other site
223283009340	dimer interface [polypeptide binding]; other site
223283009341	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283009342	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283009343	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283009344	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283009345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283009346	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283009347	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283009348	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283009349	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
223283009350	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
223283009351	FMN binding site [chemical binding]; other site
223283009352	substrate binding site [chemical binding]; other site
223283009353	putative catalytic residue [active]
223283009354	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
223283009355	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
223283009356	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
223283009357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009358	dimer interface [polypeptide binding]; other site
223283009359	conserved gate region; other site
223283009360	putative PBP binding loops; other site
223283009361	ABC-ATPase subunit interface; other site
223283009362	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
223283009363	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283009364	Walker A/P-loop; other site
223283009365	ATP binding site [chemical binding]; other site
223283009366	Q-loop/lid; other site
223283009367	ABC transporter signature motif; other site
223283009368	Walker B; other site
223283009369	D-loop; other site
223283009370	H-loop/switch region; other site
223283009371	TOBE domain; Region: TOBE; cl01440
223283009372	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
223283009373	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
223283009374	active site
223283009375	DNA binding site [nucleotide binding]
223283009376	Int/Topo IB signature motif; other site
223283009377	catalytic residues [active]
223283009378	Protein of unknown function DUF2625; Region: DUF2625; pfam10946
223283009379	Chitin binding domain; Region: Chitin_bind_3; pfam03067
223283009380	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
223283009381	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
223283009382	active site
223283009383	metal binding site [ion binding]; metal-binding site
223283009384	oxidase reductase; Provisional; Region: PTZ00273
223283009385	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
223283009386	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
223283009387	Isochorismatase family; Region: Isochorismatase; pfam00857
223283009388	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
223283009389	catalytic triad [active]
223283009390	conserved cis-peptide bond; other site
223283009391	Tannase and feruloyl esterase; Region: Tannase; pfam07519
223283009392	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283009393	dimer interface [polypeptide binding]; other site
223283009394	phosphorylation site [posttranslational modification]
223283009395	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
223283009396	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
223283009397	active site
223283009398	non-prolyl cis peptide bond; other site
223283009399	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
223283009400	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
223283009401	Flavin binding site [chemical binding]; other site
223283009402	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
223283009403	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
223283009404	Walker A/P-loop; other site
223283009405	ATP binding site [chemical binding]; other site
223283009406	Q-loop/lid; other site
223283009407	ABC transporter signature motif; other site
223283009408	Walker B; other site
223283009409	D-loop; other site
223283009410	H-loop/switch region; other site
223283009411	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
223283009412	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
223283009413	putative ligand binding site [chemical binding]; other site
223283009414	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
223283009415	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
223283009416	TM-ABC transporter signature motif; other site
223283009417	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283009418	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
223283009419	TM-ABC transporter signature motif; other site
223283009420	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
223283009421	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
223283009422	Walker A/P-loop; other site
223283009423	ATP binding site [chemical binding]; other site
223283009424	Q-loop/lid; other site
223283009425	ABC transporter signature motif; other site
223283009426	Walker B; other site
223283009427	D-loop; other site
223283009428	H-loop/switch region; other site
223283009429	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
223283009430	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
223283009431	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
223283009432	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
223283009433	Flavin binding site [chemical binding]; other site
223283009434	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
223283009435	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283009436	TM-ABC transporter signature motif; other site
223283009437	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
223283009438	TM-ABC transporter signature motif; other site
223283009439	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
223283009440	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
223283009441	Walker A/P-loop; other site
223283009442	ATP binding site [chemical binding]; other site
223283009443	Q-loop/lid; other site
223283009444	ABC transporter signature motif; other site
223283009445	Walker B; other site
223283009446	D-loop; other site
223283009447	H-loop/switch region; other site
223283009448	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
223283009449	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
223283009450	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
223283009451	putative ligand binding site [chemical binding]; other site
223283009452	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283009453	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283009454	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283009455	dimer interface [polypeptide binding]; other site
223283009456	putative CheW interface [polypeptide binding]; other site
223283009457	VirK protein; Region: VirK; pfam06903
223283009458	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
223283009459	active site
223283009460	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
223283009461	putative dimerization interface [polypeptide binding]; other site
223283009462	Transcriptional regulators [Transcription]; Region: PurR; COG1609
223283009463	putative ligand binding site [chemical binding]; other site
223283009464	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
223283009465	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283009466	xylose isomerase; Provisional; Region: PRK05474
223283009467	xylose isomerase; Region: xylose_isom_A; TIGR02630
223283009468	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
223283009469	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
223283009470	putative ligand binding site [chemical binding]; other site
223283009471	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
223283009472	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
223283009473	Walker A/P-loop; other site
223283009474	ATP binding site [chemical binding]; other site
223283009475	Q-loop/lid; other site
223283009476	ABC transporter signature motif; other site
223283009477	Walker B; other site
223283009478	D-loop; other site
223283009479	H-loop/switch region; other site
223283009480	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
223283009481	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
223283009482	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
223283009483	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283009484	TM-ABC transporter signature motif; other site
223283009485	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151
223283009486	homotrimer interaction site [polypeptide binding]; other site
223283009487	putative active site [active]
223283009488	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
223283009489	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
223283009490	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283009491	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283009492	substrate binding pocket [chemical binding]; other site
223283009493	membrane-bound complex binding site; other site
223283009494	hinge residues; other site
223283009495	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
223283009496	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283009497	Walker A/P-loop; other site
223283009498	ATP binding site [chemical binding]; other site
223283009499	Q-loop/lid; other site
223283009500	ABC transporter signature motif; other site
223283009501	Walker B; other site
223283009502	D-loop; other site
223283009503	H-loop/switch region; other site
223283009504	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283009505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009506	dimer interface [polypeptide binding]; other site
223283009507	conserved gate region; other site
223283009508	putative PBP binding loops; other site
223283009509	ABC-ATPase subunit interface; other site
223283009510	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
223283009511	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283009512	N-terminal plug; other site
223283009513	ligand-binding site [chemical binding]; other site
223283009514	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283009515	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283009516	DNA-binding interface [nucleotide binding]; DNA binding site
223283009517	Integrase core domain; Region: rve; pfam00665
223283009518	Integrase core domain; Region: rve_3; cl15866
223283009519	transposase/IS protein; Provisional; Region: PRK09183
223283009520	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283009521	Walker A motif; other site
223283009522	ATP binding site [chemical binding]; other site
223283009523	Walker B motif; other site
223283009524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
223283009525	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
223283009526	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
223283009527	DNA binding site [nucleotide binding]
223283009528	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
223283009529	putative ligand binding site [chemical binding]; other site
223283009530	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
223283009531	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
223283009532	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
223283009533	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
223283009534	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
223283009535	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
223283009536	NADP binding site [chemical binding]; other site
223283009537	active site
223283009538	regulatory binding site [polypeptide binding]; other site
223283009539	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283009540	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009541	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
223283009542	putative effector binding pocket; other site
223283009543	dimerization interface [polypeptide binding]; other site
223283009544	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
223283009545	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
223283009546	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
223283009547	GIY-YIG motif/motif A; other site
223283009548	active site
223283009549	catalytic site [active]
223283009550	putative DNA binding site [nucleotide binding]; other site
223283009551	metal binding site [ion binding]; metal-binding site
223283009552	UvrB/uvrC motif; Region: UVR; pfam02151
223283009553	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
223283009554	response regulator; Provisional; Region: PRK09483
223283009555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283009556	active site
223283009557	phosphorylation site [posttranslational modification]
223283009558	intermolecular recognition site; other site
223283009559	dimerization interface [polypeptide binding]; other site
223283009560	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283009561	DNA binding residues [nucleotide binding]
223283009562	dimerization interface [polypeptide binding]; other site
223283009563	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
223283009564	sequence-specific DNA binding site [nucleotide binding]; other site
223283009565	salt bridge; other site
223283009566	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
223283009567	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
223283009568	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
223283009569	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
223283009570	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
223283009571	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
223283009572	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
223283009573	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
223283009574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009575	dimer interface [polypeptide binding]; other site
223283009576	conserved gate region; other site
223283009577	putative PBP binding loops; other site
223283009578	ABC-ATPase subunit interface; other site
223283009579	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
223283009580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009581	dimer interface [polypeptide binding]; other site
223283009582	conserved gate region; other site
223283009583	putative PBP binding loops; other site
223283009584	ABC-ATPase subunit interface; other site
223283009585	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
223283009586	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283009587	Walker A/P-loop; other site
223283009588	ATP binding site [chemical binding]; other site
223283009589	Q-loop/lid; other site
223283009590	ABC transporter signature motif; other site
223283009591	Walker B; other site
223283009592	D-loop; other site
223283009593	H-loop/switch region; other site
223283009594	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
223283009595	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283009596	Walker A/P-loop; other site
223283009597	ATP binding site [chemical binding]; other site
223283009598	Q-loop/lid; other site
223283009599	ABC transporter signature motif; other site
223283009600	Walker B; other site
223283009601	D-loop; other site
223283009602	H-loop/switch region; other site
223283009603	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283009604	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
223283009605	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
223283009606	Walker A motif; other site
223283009607	ATP binding site [chemical binding]; other site
223283009608	Walker B motif; other site
223283009609	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
223283009610	phosphoglucomutase; Validated; Region: PRK07564
223283009611	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
223283009612	active site
223283009613	substrate binding site [chemical binding]; other site
223283009614	metal binding site [ion binding]; metal-binding site
223283009615	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
223283009616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
223283009617	DEAD_2; Region: DEAD_2; pfam06733
223283009618	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
223283009619	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
223283009620	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283009621	DNA-binding site [nucleotide binding]; DNA binding site
223283009622	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
223283009623	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283009624	catalytic residue [active]
223283009625	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
223283009626	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
223283009627	putative NAD(P) binding site [chemical binding]; other site
223283009628	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283009629	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009630	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
223283009631	putative substrate binding pocket [chemical binding]; other site
223283009632	putative dimerization interface [polypeptide binding]; other site
223283009633	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
223283009634	putative transposase OrfB; Reviewed; Region: PHA02517
223283009635	HTH-like domain; Region: HTH_21; pfam13276
223283009636	Integrase core domain; Region: rve; pfam00665
223283009637	Integrase core domain; Region: rve_3; pfam13683
223283009638	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
223283009639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283009640	Walker A motif; other site
223283009641	ATP binding site [chemical binding]; other site
223283009642	Walker B motif; other site
223283009643	arginine finger; other site
223283009644	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283009645	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
223283009646	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
223283009647	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
223283009648	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
223283009649	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
223283009650	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
223283009651	putative ligand binding site [chemical binding]; other site
223283009652	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
223283009653	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283009654	Cupin domain; Region: Cupin_2; pfam07883
223283009655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283009656	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283009657	putative substrate translocation pore; other site
223283009658	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
223283009659	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
223283009660	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283009661	NAD(P) binding site [chemical binding]; other site
223283009662	active site
223283009663	aconitate hydratase; Validated; Region: PRK09277
223283009664	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
223283009665	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
223283009666	conserved cys residue [active]
223283009667	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
223283009668	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
223283009669	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
223283009670	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
223283009671	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009672	dimer interface [polypeptide binding]; other site
223283009673	conserved gate region; other site
223283009674	putative PBP binding loops; other site
223283009675	ABC-ATPase subunit interface; other site
223283009676	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
223283009677	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
223283009678	Walker A/P-loop; other site
223283009679	ATP binding site [chemical binding]; other site
223283009680	Q-loop/lid; other site
223283009681	ABC transporter signature motif; other site
223283009682	Walker B; other site
223283009683	D-loop; other site
223283009684	H-loop/switch region; other site
223283009685	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
223283009686	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009687	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283009688	dimerization interface [polypeptide binding]; other site
223283009689	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
223283009690	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
223283009691	[2Fe-2S] cluster binding site [ion binding]; other site
223283009692	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
223283009693	putative alpha subunit interface [polypeptide binding]; other site
223283009694	putative active site [active]
223283009695	putative substrate binding site [chemical binding]; other site
223283009696	Fe binding site [ion binding]; other site
223283009697	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
223283009698	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
223283009699	inhibitor site; inhibition site
223283009700	active site
223283009701	dimer interface [polypeptide binding]; other site
223283009702	catalytic residue [active]
223283009703	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
223283009704	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
223283009705	NAD(P) binding site [chemical binding]; other site
223283009706	catalytic residues [active]
223283009707	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
223283009708	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
223283009709	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
223283009710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283009711	putative substrate translocation pore; other site
223283009712	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283009713	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283009714	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
223283009715	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283009716	Coenzyme A binding pocket [chemical binding]; other site
223283009717	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
223283009718	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
223283009719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283009720	Walker A/P-loop; other site
223283009721	ATP binding site [chemical binding]; other site
223283009722	Q-loop/lid; other site
223283009723	ABC transporter signature motif; other site
223283009724	Walker B; other site
223283009725	D-loop; other site
223283009726	H-loop/switch region; other site
223283009727	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
223283009728	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
223283009729	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
223283009730	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283009731	NAD(P) binding site [chemical binding]; other site
223283009732	active site
223283009733	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
223283009734	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283009735	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
223283009736	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
223283009737	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
223283009738	active site
223283009739	catalytic tetrad [active]
223283009740	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283009741	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283009742	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
223283009743	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
223283009744	FMN binding site [chemical binding]; other site
223283009745	active site
223283009746	substrate binding site [chemical binding]; other site
223283009747	catalytic residue [active]
223283009748	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
223283009749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283009750	NADH(P)-binding; Region: NAD_binding_10; pfam13460
223283009751	NAD(P) binding site [chemical binding]; other site
223283009752	active site
223283009753	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
223283009754	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
223283009755	active site
223283009756	FMN binding site [chemical binding]; other site
223283009757	substrate binding site [chemical binding]; other site
223283009758	putative catalytic residue [active]
223283009759	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283009760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009761	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
223283009762	putative effector binding pocket; other site
223283009763	dimerization interface [polypeptide binding]; other site
223283009764	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
223283009765	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283009766	substrate binding pocket [chemical binding]; other site
223283009767	membrane-bound complex binding site; other site
223283009768	hinge residues; other site
223283009769	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
223283009770	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283009771	Walker A/P-loop; other site
223283009772	ATP binding site [chemical binding]; other site
223283009773	Q-loop/lid; other site
223283009774	ABC transporter signature motif; other site
223283009775	Walker B; other site
223283009776	D-loop; other site
223283009777	H-loop/switch region; other site
223283009778	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009779	dimer interface [polypeptide binding]; other site
223283009780	conserved gate region; other site
223283009781	putative PBP binding loops; other site
223283009782	ABC-ATPase subunit interface; other site
223283009783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009784	dimer interface [polypeptide binding]; other site
223283009785	conserved gate region; other site
223283009786	putative PBP binding loops; other site
223283009787	ABC-ATPase subunit interface; other site
223283009788	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
223283009789	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283009790	non-specific DNA binding site [nucleotide binding]; other site
223283009791	salt bridge; other site
223283009792	sequence-specific DNA binding site [nucleotide binding]; other site
223283009793	Cupin domain; Region: Cupin_2; pfam07883
223283009794	Pto-interacting domain of the HopAB family of Type III Effector proteins; Region: HopAB_PID; cd12802
223283009795	Pto binding site [polypeptide binding]; other site
223283009796	BAK1-interacting domain of the HopAB family of Type III Effector proteins; Region: HopAB_BID; cd12803
223283009797	BAK1 binding site [polypeptide binding]; other site
223283009798	AvrPtoB E3 ubiquitin ligase; Region: AvrPtoB-E3_ubiq; pfam09046
223283009799	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
223283009800	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
223283009801	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
223283009802	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009803	dimer interface [polypeptide binding]; other site
223283009804	conserved gate region; other site
223283009805	putative PBP binding loops; other site
223283009806	ABC-ATPase subunit interface; other site
223283009807	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
223283009808	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283009809	dimer interface [polypeptide binding]; other site
223283009810	conserved gate region; other site
223283009811	putative PBP binding loops; other site
223283009812	ABC-ATPase subunit interface; other site
223283009813	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
223283009814	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283009815	Walker A/P-loop; other site
223283009816	ATP binding site [chemical binding]; other site
223283009817	Q-loop/lid; other site
223283009818	ABC transporter signature motif; other site
223283009819	Walker B; other site
223283009820	D-loop; other site
223283009821	H-loop/switch region; other site
223283009822	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283009823	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283009824	Walker A/P-loop; other site
223283009825	ATP binding site [chemical binding]; other site
223283009826	Q-loop/lid; other site
223283009827	ABC transporter signature motif; other site
223283009828	Walker B; other site
223283009829	D-loop; other site
223283009830	H-loop/switch region; other site
223283009831	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283009832	Predicted methyltransferase [General function prediction only]; Region: COG4798
223283009833	Methyltransferase domain; Region: Methyltransf_23; pfam13489
223283009834	S-adenosylmethionine binding site [chemical binding]; other site
223283009835	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
223283009836	BRO family, N-terminal domain; Region: Bro-N; smart01040
223283009837	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283009838	dimerization interface [polypeptide binding]; other site
223283009839	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283009840	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283009841	dimer interface [polypeptide binding]; other site
223283009842	putative CheW interface [polypeptide binding]; other site
223283009843	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
223283009844	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283009845	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283009846	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
223283009847	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
223283009848	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283009849	TPR motif; other site
223283009850	Tetratricopeptide repeat; Region: TPR_16; pfam13432
223283009851	binding surface
223283009852	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283009853	binding surface
223283009854	TPR motif; other site
223283009855	TPR repeat; Region: TPR_11; pfam13414
223283009856	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
223283009857	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
223283009858	dimer interface [polypeptide binding]; other site
223283009859	active site
223283009860	metal binding site [ion binding]; metal-binding site
223283009861	glutathione binding site [chemical binding]; other site
223283009862	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
223283009863	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
223283009864	catalytic residue [active]
223283009865	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
223283009866	catalytic residues [active]
223283009867	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283009868	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283009869	peroxiredoxin; Region: AhpC; TIGR03137
223283009870	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
223283009871	dimer interface [polypeptide binding]; other site
223283009872	decamer (pentamer of dimers) interface [polypeptide binding]; other site
223283009873	catalytic triad [active]
223283009874	peroxidatic and resolving cysteines [active]
223283009875	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
223283009876	DNA binding site [nucleotide binding]
223283009877	dimer interface [polypeptide binding]; other site
223283009878	active site
223283009879	Int/Topo IB signature motif; other site
223283009880	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
223283009881	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283009882	PAS domain; Region: PAS_9; pfam13426
223283009883	putative active site [active]
223283009884	heme pocket [chemical binding]; other site
223283009885	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283009886	dimer interface [polypeptide binding]; other site
223283009887	phosphorylation site [posttranslational modification]
223283009888	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283009889	ATP binding site [chemical binding]; other site
223283009890	Mg2+ binding site [ion binding]; other site
223283009891	G-X-G motif; other site
223283009892	glutathione reductase; Validated; Region: PRK06116
223283009893	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283009894	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283009895	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
223283009896	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
223283009897	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
223283009898	active site
223283009899	tetramer interface; other site
223283009900	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
223283009901	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
223283009902	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
223283009903	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
223283009904	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
223283009905	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
223283009906	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283009907	active site
223283009908	motif I; other site
223283009909	motif II; other site
223283009910	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283009911	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
223283009912	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
223283009913	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
223283009914	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
223283009915	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
223283009916	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
223283009917	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283009918	Coenzyme A binding pocket [chemical binding]; other site
223283009919	glycogen synthase; Provisional; Region: glgA; PRK00654
223283009920	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
223283009921	ADP-binding pocket [chemical binding]; other site
223283009922	homodimer interface [polypeptide binding]; other site
223283009923	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
223283009924	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
223283009925	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
223283009926	catalytic site [active]
223283009927	active site
223283009928	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
223283009929	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
223283009930	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
223283009931	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
223283009932	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
223283009933	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
223283009934	active site
223283009935	catalytic site [active]
223283009936	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
223283009937	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
223283009938	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
223283009939	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
223283009940	active site
223283009941	catalytic site [active]
223283009942	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
223283009943	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
223283009944	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
223283009945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283009946	S-adenosylmethionine binding site [chemical binding]; other site
223283009947	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
223283009948	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
223283009949	active site
223283009950	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
223283009951	azoreductase; Reviewed; Region: PRK00170
223283009952	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
223283009953	LysR family transcriptional regulator; Provisional; Region: PRK14997
223283009954	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283009955	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
223283009956	putative effector binding pocket; other site
223283009957	putative dimerization interface [polypeptide binding]; other site
223283009958	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
223283009959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
223283009960	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
223283009961	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
223283009962	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
223283009963	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
223283009964	AAA domain; Region: AAA_28; pfam13521
223283009965	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
223283009966	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283009967	Walker A motif; other site
223283009968	ATP binding site [chemical binding]; other site
223283009969	Walker B motif; other site
223283009970	arginine finger; other site
223283009971	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283009972	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
223283009973	Transposase; Region: DEDD_Tnp_IS110; pfam01548
223283009974	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
223283009975	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
223283009976	metal ion-dependent adhesion site (MIDAS); other site
223283009977	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
223283009978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283009979	Walker A motif; other site
223283009980	ATP binding site [chemical binding]; other site
223283009981	Walker B motif; other site
223283009982	arginine finger; other site
223283009983	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
223283009984	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
223283009985	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
223283009986	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
223283009987	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
223283009988	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
223283009989	cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459
223283009990	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
223283009991	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
223283009992	active site
223283009993	SAM binding site [chemical binding]; other site
223283009994	homodimer interface [polypeptide binding]; other site
223283009995	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
223283009996	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
223283009997	dimer interface [polypeptide binding]; other site
223283009998	PYR/PP interface [polypeptide binding]; other site
223283009999	TPP binding site [chemical binding]; other site
223283010000	substrate binding site [chemical binding]; other site
223283010001	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
223283010002	TPP-binding site; other site
223283010003	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
223283010004	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
223283010005	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283010006	putative DNA binding site [nucleotide binding]; other site
223283010007	putative Zn2+ binding site [ion binding]; other site
223283010008	AsnC family; Region: AsnC_trans_reg; pfam01037
223283010009	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283010010	DNA binding residues [nucleotide binding]
223283010011	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
223283010012	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
223283010013	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283010014	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283010015	Leucine rich repeat; Region: LRR_8; pfam13855
223283010016	Leucine rich repeat; Region: LRR_8; pfam13855
223283010017	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
223283010018	Catalytic domain of Protein Kinases; Region: PKc; cd00180
223283010019	active site
223283010020	ATP binding site [chemical binding]; other site
223283010021	substrate binding site [chemical binding]; other site
223283010022	activation loop (A-loop); other site
223283010023	hypothetical protein; Provisional; Region: PRK12378
223283010024	enoyl-CoA hydratase; Provisional; Region: PRK05862
223283010025	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
223283010026	substrate binding site [chemical binding]; other site
223283010027	oxyanion hole (OAH) forming residues; other site
223283010028	trimer interface [polypeptide binding]; other site
223283010029	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
223283010030	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
223283010031	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
223283010032	dimer interface [polypeptide binding]; other site
223283010033	active site
223283010034	Water Stress and Hypersensitive response; Region: WHy; smart00769
223283010035	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
223283010036	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
223283010037	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
223283010038	PA14 domain; Region: PA14; pfam07691
223283010039	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
223283010040	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283010041	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283010042	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
223283010043	putative efflux protein, MATE family; Region: matE; TIGR00797
223283010044	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
223283010045	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
223283010046	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
223283010047	active site
223283010048	Zn binding site [ion binding]; other site
223283010049	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
223283010050	mce related protein; Region: MCE; pfam02470
223283010051	mce related protein; Region: MCE; pfam02470
223283010052	mce related protein; Region: MCE; pfam02470
223283010053	Protein of unknown function (DUF330); Region: DUF330; pfam03886
223283010054	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
223283010055	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283010056	non-specific DNA binding site [nucleotide binding]; other site
223283010057	salt bridge; other site
223283010058	sequence-specific DNA binding site [nucleotide binding]; other site
223283010059	LysR family transcriptional regulator; Provisional; Region: PRK14997
223283010060	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283010061	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
223283010062	putative effector binding pocket; other site
223283010063	dimerization interface [polypeptide binding]; other site
223283010064	Pirin-related protein [General function prediction only]; Region: COG1741
223283010065	Pirin; Region: Pirin; pfam02678
223283010066	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
223283010067	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
223283010068	active site
223283010069	catalytic tetrad [active]
223283010070	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
223283010071	Na binding site [ion binding]; other site
223283010072	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
223283010073	Phosphotransferase enzyme family; Region: APH; pfam01636
223283010074	active site
223283010075	ATP binding site [chemical binding]; other site
223283010076	substrate binding site [chemical binding]; other site
223283010077	dimer interface [polypeptide binding]; other site
223283010078	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
223283010079	active site
223283010080	ATP binding site [chemical binding]; other site
223283010081	substrate binding site [chemical binding]; other site
223283010082	dimer interface [polypeptide binding]; other site
223283010083	Phosphotransferase enzyme family; Region: APH; pfam01636
223283010084	allantoate amidohydrolase; Reviewed; Region: PRK09290
223283010085	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
223283010086	active site
223283010087	metal binding site [ion binding]; metal-binding site
223283010088	dimer interface [polypeptide binding]; other site
223283010089	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
223283010090	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
223283010091	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
223283010092	putative amidase; Provisional; Region: PRK06169
223283010093	Amidase; Region: Amidase; pfam01425
223283010094	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
223283010095	active site
223283010096	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
223283010097	Transposase domain (DUF772); Region: DUF772; pfam05598
223283010098	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283010099	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283010100	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
223283010101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283010102	ATP binding site [chemical binding]; other site
223283010103	Mg2+ binding site [ion binding]; other site
223283010104	G-X-G motif; other site
223283010105	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283010106	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283010107	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
223283010108	putative effector binding pocket; other site
223283010109	putative dimerization interface [polypeptide binding]; other site
223283010110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283010111	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283010112	putative substrate translocation pore; other site
223283010113	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
223283010114	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
223283010115	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
223283010116	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
223283010117	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
223283010118	active site
223283010119	dimer interface [polypeptide binding]; other site
223283010120	non-prolyl cis peptide bond; other site
223283010121	insertion regions; other site
223283010122	Nitronate monooxygenase; Region: NMO; pfam03060
223283010123	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
223283010124	FMN binding site [chemical binding]; other site
223283010125	substrate binding site [chemical binding]; other site
223283010126	putative catalytic residue [active]
223283010127	hypothetical protein; Validated; Region: PRK06201
223283010128	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
223283010129	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
223283010130	tartrate dehydrogenase; Region: TTC; TIGR02089
223283010131	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283010132	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283010133	LysR substrate binding domain; Region: LysR_substrate; pfam03466
223283010134	dimerization interface [polypeptide binding]; other site
223283010135	Transposase domain (DUF772); Region: DUF772; pfam05598
223283010136	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283010137	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283010138	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
223283010139	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
223283010140	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
223283010141	Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; pfam10004
223283010142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283010143	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283010144	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283010145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283010146	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283010147	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283010148	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283010149	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283010150	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283010151	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283010152	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283010153	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283010154	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283010155	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283010156	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
223283010157	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283010158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283010159	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283010160	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283010161	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283010162	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283010163	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283010164	Transposase domain (DUF772); Region: DUF772; pfam05598
223283010165	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283010166	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
223283010167	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283010168	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283010169	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283010170	DNA-binding interface [nucleotide binding]; DNA binding site
223283010171	Integrase core domain; Region: rve; pfam00665
223283010172	Integrase core domain; Region: rve_3; cl15866
223283010173	transposase/IS protein; Provisional; Region: PRK09183
223283010174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283010175	Walker A motif; other site
223283010176	ATP binding site [chemical binding]; other site
223283010177	Walker B motif; other site
223283010178	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
223283010179	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
223283010180	haemagglutination activity domain; Region: Haemagg_act; pfam05860
223283010181	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
223283010182	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
223283010183	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
223283010184	protein-splicing catalytic site; other site
223283010185	thioester formation/cholesterol transfer; other site
223283010186	Pretoxin HINT domain; Region: PT-HINT; pfam07591
223283010187	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
223283010188	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
223283010189	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
223283010190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283010191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283010192	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
223283010193	putative dimerization interface [polypeptide binding]; other site
223283010194	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
223283010195	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
223283010196	putative metal binding site [ion binding]; other site
223283010197	glutamate carboxypeptidase; Reviewed; Region: PRK06133
223283010198	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
223283010199	metal binding site [ion binding]; metal-binding site
223283010200	dimer interface [polypeptide binding]; other site
223283010201	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
223283010202	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
223283010203	Sulfate transporter family; Region: Sulfate_transp; pfam00916
223283010204	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
223283010205	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
223283010206	dimerization interface [polypeptide binding]; other site
223283010207	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283010208	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283010209	dimer interface [polypeptide binding]; other site
223283010210	putative CheW interface [polypeptide binding]; other site
223283010211	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
223283010212	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
223283010213	TolR protein; Region: tolR; TIGR02801
223283010214	TolQ protein; Region: tolQ; TIGR02796
223283010215	Phytase; Region: Phytase; cl17685
223283010216	Phytase; Region: Phytase; cl17685
223283010217	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
223283010218	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
223283010219	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283010220	ligand-binding site [chemical binding]; other site
223283010221	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283010222	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283010223	metal binding site [ion binding]; metal-binding site
223283010224	active site
223283010225	I-site; other site
223283010226	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
223283010227	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
223283010228	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
223283010229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283010230	active site
223283010231	phosphorylation site [posttranslational modification]
223283010232	intermolecular recognition site; other site
223283010233	dimerization interface [polypeptide binding]; other site
223283010234	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283010235	DNA binding site [nucleotide binding]
223283010236	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
223283010237	catalytic core [active]
223283010238	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329
223283010239	galactonate dehydratase; Provisional; Region: PRK14017
223283010240	putative active site pocket [active]
223283010241	metal binding site [ion binding]; metal-binding site
223283010242	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
223283010243	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
223283010244	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
223283010245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283010246	dimer interface [polypeptide binding]; other site
223283010247	conserved gate region; other site
223283010248	putative PBP binding loops; other site
223283010249	ABC-ATPase subunit interface; other site
223283010250	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
223283010251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283010252	dimer interface [polypeptide binding]; other site
223283010253	conserved gate region; other site
223283010254	ABC-ATPase subunit interface; other site
223283010255	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
223283010256	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283010257	Walker A/P-loop; other site
223283010258	ATP binding site [chemical binding]; other site
223283010259	Q-loop/lid; other site
223283010260	ABC transporter signature motif; other site
223283010261	Walker B; other site
223283010262	D-loop; other site
223283010263	H-loop/switch region; other site
223283010264	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283010265	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
223283010266	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283010267	Walker A/P-loop; other site
223283010268	ATP binding site [chemical binding]; other site
223283010269	Q-loop/lid; other site
223283010270	ABC transporter signature motif; other site
223283010271	Walker B; other site
223283010272	D-loop; other site
223283010273	H-loop/switch region; other site
223283010274	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
223283010275	Transcriptional regulators [Transcription]; Region: FadR; COG2186
223283010276	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283010277	DNA-binding site [nucleotide binding]; DNA binding site
223283010278	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
223283010279	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
223283010280	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
223283010281	putative ligand binding residues [chemical binding]; other site
223283010282	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
223283010283	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
223283010284	ABC-ATPase subunit  interface; other site
223283010285	dimer interface [polypeptide binding]; other site
223283010286	putative PBP binding regions; other site
223283010287	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
223283010288	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
223283010289	Walker A/P-loop; other site
223283010290	ATP binding site [chemical binding]; other site
223283010291	Q-loop/lid; other site
223283010292	ABC transporter signature motif; other site
223283010293	Walker B; other site
223283010294	D-loop; other site
223283010295	H-loop/switch region; other site
223283010296	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
223283010297	Peptidase family U32; Region: Peptidase_U32; pfam01136
223283010298	Collagenase; Region: DUF3656; pfam12392
223283010299	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
223283010300	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283010301	Coenzyme A binding pocket [chemical binding]; other site
223283010302	nitrite reductase subunit NirD; Provisional; Region: PRK14989
223283010303	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283010304	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
223283010305	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
223283010306	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
223283010307	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
223283010308	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
223283010309	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283010310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283010311	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
223283010312	putative substrate binding pocket [chemical binding]; other site
223283010313	putative dimerization interface [polypeptide binding]; other site
223283010314	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
223283010315	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
223283010316	Walker A/P-loop; other site
223283010317	ATP binding site [chemical binding]; other site
223283010318	Q-loop/lid; other site
223283010319	ABC transporter signature motif; other site
223283010320	Walker B; other site
223283010321	D-loop; other site
223283010322	H-loop/switch region; other site
223283010323	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
223283010324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283010325	dimer interface [polypeptide binding]; other site
223283010326	conserved gate region; other site
223283010327	putative PBP binding loops; other site
223283010328	ABC-ATPase subunit interface; other site
223283010329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283010330	dimer interface [polypeptide binding]; other site
223283010331	conserved gate region; other site
223283010332	putative PBP binding loops; other site
223283010333	ABC-ATPase subunit interface; other site
223283010334	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
223283010335	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
223283010336	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
223283010337	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
223283010338	Transposase; Region: DEDD_Tnp_IS110; pfam01548
223283010339	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
223283010340	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283010341	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283010342	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
223283010343	putative dimerization interface [polypeptide binding]; other site
223283010344	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
223283010345	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
223283010346	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
223283010347	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
223283010348	putative active cleft [active]
223283010349	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283010350	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283010351	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283010352	dimerization interface [polypeptide binding]; other site
223283010353	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283010354	dimer interface [polypeptide binding]; other site
223283010355	putative CheW interface [polypeptide binding]; other site
223283010356	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
223283010357	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
223283010358	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
223283010359	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
223283010360	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
223283010361	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
223283010362	Transcriptional regulators [Transcription]; Region: FadR; COG2186
223283010363	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283010364	DNA-binding site [nucleotide binding]; DNA binding site
223283010365	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
223283010366	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
223283010367	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283010368	putative substrate translocation pore; other site
223283010369	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
223283010370	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
223283010371	active site
223283010372	tetramer interface [polypeptide binding]; other site
223283010373	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
223283010374	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
223283010375	dimerization interface [polypeptide binding]; other site
223283010376	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
223283010377	NAD binding site [chemical binding]; other site
223283010378	ligand binding site [chemical binding]; other site
223283010379	catalytic site [active]
223283010380	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
223283010381	outer membrane porin, OprD family; Region: OprD; pfam03573
223283010382	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
223283010383	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283010384	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283010385	HAMP domain; Region: HAMP; pfam00672
223283010386	dimerization interface [polypeptide binding]; other site
223283010387	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283010388	dimer interface [polypeptide binding]; other site
223283010389	putative CheW interface [polypeptide binding]; other site
223283010390	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283010391	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283010392	N-terminal plug; other site
223283010393	ligand-binding site [chemical binding]; other site
223283010394	Isochorismatase family; Region: Isochorismatase; pfam00857
223283010395	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
223283010396	catalytic triad [active]
223283010397	metal binding site [ion binding]; metal-binding site
223283010398	conserved cis-peptide bond; other site
223283010399	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
223283010400	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
223283010401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283010402	active site
223283010403	phosphorylation site [posttranslational modification]
223283010404	intermolecular recognition site; other site
223283010405	dimerization interface [polypeptide binding]; other site
223283010406	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283010407	DNA binding site [nucleotide binding]
223283010408	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283010409	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283010410	dimerization interface [polypeptide binding]; other site
223283010411	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283010412	dimer interface [polypeptide binding]; other site
223283010413	phosphorylation site [posttranslational modification]
223283010414	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283010415	ATP binding site [chemical binding]; other site
223283010416	Mg2+ binding site [ion binding]; other site
223283010417	G-X-G motif; other site
223283010418	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
223283010419	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
223283010420	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283010421	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283010422	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
223283010423	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283010424	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283010425	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
223283010426	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
223283010427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283010428	putative substrate translocation pore; other site
223283010429	Predicted esterase [General function prediction only]; Region: COG0400
223283010430	putative hydrolase; Provisional; Region: PRK11460
223283010431	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
223283010432	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
223283010433	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
223283010434	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
223283010435	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
223283010436	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
223283010437	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
223283010438	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
223283010439	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
223283010440	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
223283010441	general secretion pathway protein J; Validated; Region: PRK08808
223283010442	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
223283010443	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
223283010444	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
223283010445	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
223283010446	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
223283010447	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
223283010448	type II secretion system protein F; Region: GspF; TIGR02120
223283010449	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
223283010450	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
223283010451	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
223283010452	type II secretion system protein E; Region: type_II_gspE; TIGR02533
223283010453	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
223283010454	Walker A motif; other site
223283010455	ATP binding site [chemical binding]; other site
223283010456	Walker B motif; other site
223283010457	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
223283010458	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
223283010459	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
223283010460	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
223283010461	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
223283010462	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283010463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283010464	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
223283010465	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
223283010466	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283010467	Coenzyme A binding pocket [chemical binding]; other site
223283010468	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283010469	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283010470	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
223283010471	dimerization interface [polypeptide binding]; other site
223283010472	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
223283010473	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
223283010474	dimer interface [polypeptide binding]; other site
223283010475	NADP binding site [chemical binding]; other site
223283010476	catalytic residues [active]
223283010477	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
223283010478	Transposase; Region: DEDD_Tnp_IS110; pfam01548
223283010479	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
223283010480	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
223283010481	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
223283010482	putative active site [active]
223283010483	putative NTP binding site [chemical binding]; other site
223283010484	putative nucleic acid binding site [nucleotide binding]; other site
223283010485	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
223283010486	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
223283010487	hydroxyglutarate oxidase; Provisional; Region: PRK11728
223283010488	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
223283010489	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
223283010490	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283010491	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283010492	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
223283010493	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
223283010494	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
223283010495	Walker A/P-loop; other site
223283010496	ATP binding site [chemical binding]; other site
223283010497	Q-loop/lid; other site
223283010498	ABC transporter signature motif; other site
223283010499	Walker B; other site
223283010500	D-loop; other site
223283010501	H-loop/switch region; other site
223283010502	Protease inhibitor Inh; Region: Inh; pfam02974
223283010503	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
223283010504	active site
223283010505	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
223283010506	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
223283010507	YccA-like proteins; Region: YccA_like; cd10433
223283010508	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283010509	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283010510	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
223283010511	putative dimerization interface [polypeptide binding]; other site
223283010512	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
223283010513	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
223283010514	citrate-proton symporter; Provisional; Region: PRK15075
223283010515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283010516	putative substrate translocation pore; other site
223283010517	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
223283010518	sulfur relay protein TusC; Validated; Region: PRK00211
223283010519	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
223283010520	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
223283010521	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
223283010522	hypothetical protein; Validated; Region: PRK09071
223283010523	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
223283010524	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
223283010525	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
223283010526	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
223283010527	putative dimer interface [polypeptide binding]; other site
223283010528	N-terminal domain interface [polypeptide binding]; other site
223283010529	putative substrate binding pocket (H-site) [chemical binding]; other site
223283010530	siroheme synthase; Provisional; Region: cysG; PRK10637
223283010531	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
223283010532	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
223283010533	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
223283010534	active site
223283010535	SAM binding site [chemical binding]; other site
223283010536	homodimer interface [polypeptide binding]; other site
223283010537	seryl-tRNA synthetase; Provisional; Region: PRK05431
223283010538	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
223283010539	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
223283010540	dimer interface [polypeptide binding]; other site
223283010541	active site
223283010542	motif 1; other site
223283010543	motif 2; other site
223283010544	motif 3; other site
223283010545	camphor resistance protein CrcB; Provisional; Region: PRK14234
223283010546	recombination factor protein RarA; Reviewed; Region: PRK13342
223283010547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283010548	Walker A motif; other site
223283010549	ATP binding site [chemical binding]; other site
223283010550	Walker B motif; other site
223283010551	arginine finger; other site
223283010552	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
223283010553	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
223283010554	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
223283010555	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
223283010556	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
223283010557	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
223283010558	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
223283010559	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
223283010560	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
223283010561	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
223283010562	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
223283010563	rRNA binding site [nucleotide binding]; other site
223283010564	predicted 30S ribosome binding site; other site
223283010565	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
223283010566	Clp amino terminal domain; Region: Clp_N; pfam02861
223283010567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283010568	Walker A motif; other site
223283010569	ATP binding site [chemical binding]; other site
223283010570	Walker B motif; other site
223283010571	arginine finger; other site
223283010572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283010573	Walker A motif; other site
223283010574	ATP binding site [chemical binding]; other site
223283010575	Walker B motif; other site
223283010576	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
223283010577	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
223283010578	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
223283010579	DNA-binding site [nucleotide binding]; DNA binding site
223283010580	RNA-binding motif; other site
223283010581	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
223283010582	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
223283010583	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
223283010584	nudix motif; other site
223283010585	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
223283010586	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
223283010587	putative lysogenization regulator; Reviewed; Region: PRK00218
223283010588	adenylosuccinate lyase; Provisional; Region: PRK09285
223283010589	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
223283010590	tetramer interface [polypeptide binding]; other site
223283010591	active site
223283010592	Uncharacterized conserved protein [Function unknown]; Region: COG2850
223283010593	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
223283010594	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283010595	Coenzyme A binding pocket [chemical binding]; other site
223283010596	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
223283010597	isocitrate lyase; Provisional; Region: PRK15063
223283010598	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
223283010599	tetramer interface [polypeptide binding]; other site
223283010600	active site
223283010601	Mg2+/Mn2+ binding site [ion binding]; other site
223283010602	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
223283010603	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
223283010604	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
223283010605	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
223283010606	NADH dehydrogenase subunit D; Validated; Region: PRK06075
223283010607	NADH dehydrogenase subunit E; Validated; Region: PRK07539
223283010608	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
223283010609	putative dimer interface [polypeptide binding]; other site
223283010610	[2Fe-2S] cluster binding site [ion binding]; other site
223283010611	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
223283010612	SLBB domain; Region: SLBB; pfam10531
223283010613	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
223283010614	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
223283010615	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
223283010616	catalytic loop [active]
223283010617	iron binding site [ion binding]; other site
223283010618	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
223283010619	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
223283010620	[4Fe-4S] binding site [ion binding]; other site
223283010621	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
223283010622	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
223283010623	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
223283010624	4Fe-4S binding domain; Region: Fer4; pfam00037
223283010625	4Fe-4S binding domain; Region: Fer4; pfam00037
223283010626	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
223283010627	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
223283010628	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
223283010629	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
223283010630	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
223283010631	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
223283010632	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
223283010633	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
223283010634	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
223283010635	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
223283010636	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
223283010637	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
223283010638	Domain of unknown function DUF20; Region: UPF0118; pfam01594
223283010639	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
223283010640	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283010641	dimerization interface [polypeptide binding]; other site
223283010642	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283010643	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283010644	dimer interface [polypeptide binding]; other site
223283010645	putative CheW interface [polypeptide binding]; other site
223283010646	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
223283010647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283010648	ATP binding site [chemical binding]; other site
223283010649	Mg2+ binding site [ion binding]; other site
223283010650	G-X-G motif; other site
223283010651	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
223283010652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283010653	active site
223283010654	phosphorylation site [posttranslational modification]
223283010655	intermolecular recognition site; other site
223283010656	dimerization interface [polypeptide binding]; other site
223283010657	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283010658	DNA binding site [nucleotide binding]
223283010659	Predicted membrane protein [Function unknown]; Region: COG3212
223283010660	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
223283010661	Predicted membrane protein [Function unknown]; Region: COG3212
223283010662	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
223283010663	PHAGE03; putative prophage; putative P2-like integrated prophage; attL/R=a[gt]tggaaatcttcaaa. Targeted end5 of ORF08953 - 6-pyruvoyl tetrahydrobiopterin syntase
223283010664	integrase; Provisional; Region: PRK09692
223283010665	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
223283010666	active site
223283010667	Int/Topo IB signature motif; other site
223283010668	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
223283010669	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
223283010670	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
223283010671	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
223283010672	Predicted chitinase [General function prediction only]; Region: COG3179
223283010673	catalytic residue [active]
223283010674	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
223283010675	Phage Tail Protein X; Region: Phage_tail_X; cl02088
223283010676	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
223283010677	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
223283010678	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
223283010679	Phage tail tube protein FII; Region: Phage_tube; pfam04985
223283010680	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
223283010681	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
223283010682	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
223283010683	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
223283010684	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
223283010685	Baseplate J-like protein; Region: Baseplate_J; cl01294
223283010686	Phage baseplate assembly protein W [General function prediction only]; Region: COG3628
223283010687	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
223283010688	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
223283010689	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
223283010690	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
223283010691	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
223283010692	oligomer interface [polypeptide binding]; other site
223283010693	active site residues [active]
223283010694	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
223283010695	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
223283010696	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
223283010697	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
223283010698	Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106
223283010699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
223283010700	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
223283010701	interdomain interaction site; other site
223283010702	active site
223283010703	metal binding site [ion binding]; metal-binding site
223283010704	Virulence-associated protein E; Region: VirE; pfam05272
223283010705	phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419
223283010706	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
223283010707	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
223283010708	Catalytic site [active]
223283010709	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
223283010710	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
223283010711	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
223283010712	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
223283010713	DNA binding site [nucleotide binding]
223283010714	substrate interaction site [chemical binding]; other site
223283010715	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
223283010716	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
223283010717	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
223283010718	active site
223283010719	transposase/IS protein; Provisional; Region: PRK09183
223283010720	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283010721	Walker A motif; other site
223283010722	ATP binding site [chemical binding]; other site
223283010723	Walker B motif; other site
223283010724	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283010725	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283010726	DNA-binding interface [nucleotide binding]; DNA binding site
223283010727	Integrase core domain; Region: rve; pfam00665
223283010728	Integrase core domain; Region: rve_3; cl15866
223283010729	Hydrophobic abundant protein (HAP); Region: HAP; pfam03866
223283010730	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
223283010731	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
223283010732	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
223283010733	active site
223283010734	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
223283010735	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
223283010736	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283010737	catalytic residue [active]
223283010738	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
223283010739	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
223283010740	inhibitor-cofactor binding pocket; inhibition site
223283010741	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283010742	catalytic residue [active]
223283010743	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
223283010744	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
223283010745	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
223283010746	active site
223283010747	Low molecular weight phosphatase family; Region: LMWPc; cd00115
223283010748	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
223283010749	active site
223283010750	tyrosine kinase; Provisional; Region: PRK11519
223283010751	Chain length determinant protein; Region: Wzz; pfam02706
223283010752	Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224
223283010753	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
223283010754	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
223283010755	Nucleotide binding site [chemical binding]; other site
223283010756	P loop; other site
223283010757	DTAP/Switch II; other site
223283010758	Switch I; other site
223283010759	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
223283010760	transcriptional activator RfaH; Region: RfaH; TIGR01955
223283010761	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
223283010762	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
223283010763	active site
223283010764	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
223283010765	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283010766	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
223283010767	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283010768	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
223283010769	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283010770	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
223283010771	putative ADP-binding pocket [chemical binding]; other site
223283010772	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
223283010773	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
223283010774	Bacterial sugar transferase; Region: Bac_transf; pfam02397
223283010775	polysaccharide export protein Wza; Provisional; Region: PRK15078
223283010776	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
223283010777	SLBB domain; Region: SLBB; pfam10531
223283010778	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
223283010779	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
223283010780	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
223283010781	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283010782	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283010783	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
223283010784	putative dimerization interface [polypeptide binding]; other site
223283010785	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
223283010786	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
223283010787	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
223283010788	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
223283010789	hypothetical protein; Validated; Region: PRK06186
223283010790	conserved cys residue [active]
223283010791	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
223283010792	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
223283010793	putative ligand binding site [chemical binding]; other site
223283010794	NAD binding site [chemical binding]; other site
223283010795	catalytic site [active]
223283010796	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
223283010797	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
223283010798	active site
223283010799	catalytic site [active]
223283010800	metal binding site [ion binding]; metal-binding site
223283010801	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283010802	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283010803	N-terminal plug; other site
223283010804	ligand-binding site [chemical binding]; other site
223283010805	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
223283010806	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
223283010807	domain interface [polypeptide binding]; other site
223283010808	putative active site [active]
223283010809	catalytic site [active]
223283010810	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
223283010811	domain interface [polypeptide binding]; other site
223283010812	putative active site [active]
223283010813	catalytic site [active]
223283010814	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
223283010815	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
223283010816	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
223283010817	active site
223283010818	DNA binding site [nucleotide binding]
223283010819	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
223283010820	DNA binding site [nucleotide binding]
223283010821	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
223283010822	nucleotide binding site [chemical binding]; other site
223283010823	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
223283010824	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
223283010825	putative DNA binding site [nucleotide binding]; other site
223283010826	putative homodimer interface [polypeptide binding]; other site
223283010827	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
223283010828	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
223283010829	active site
223283010830	dimer interface [polypeptide binding]; other site
223283010831	non-prolyl cis peptide bond; other site
223283010832	insertion regions; other site
223283010833	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
223283010834	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283010835	Walker A motif; other site
223283010836	ATP binding site [chemical binding]; other site
223283010837	Walker B motif; other site
223283010838	arginine finger; other site
223283010839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
223283010840	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
223283010841	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283010842	non-specific DNA binding site [nucleotide binding]; other site
223283010843	salt bridge; other site
223283010844	sequence-specific DNA binding site [nucleotide binding]; other site
223283010845	Cupin domain; Region: Cupin_2; pfam07883
223283010846	EamA-like transporter family; Region: EamA; pfam00892
223283010847	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
223283010848	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
223283010849	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
223283010850	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
223283010851	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
223283010852	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
223283010853	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
223283010854	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
223283010855	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
223283010856	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
223283010857	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
223283010858	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
223283010859	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
223283010860	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
223283010861	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283010862	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283010863	dimer interface [polypeptide binding]; other site
223283010864	putative CheW interface [polypeptide binding]; other site
223283010865	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
223283010866	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
223283010867	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
223283010868	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
223283010869	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
223283010870	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
223283010871	active site flap/lid [active]
223283010872	nucleophilic elbow; other site
223283010873	catalytic triad [active]
223283010874	Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928
223283010875	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
223283010876	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
223283010877	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283010878	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
223283010879	TM-ABC transporter signature motif; other site
223283010880	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
223283010881	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
223283010882	Walker A/P-loop; other site
223283010883	ATP binding site [chemical binding]; other site
223283010884	Q-loop/lid; other site
223283010885	ABC transporter signature motif; other site
223283010886	Walker B; other site
223283010887	D-loop; other site
223283010888	H-loop/switch region; other site
223283010889	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
223283010890	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
223283010891	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
223283010892	putative ligand binding site [chemical binding]; other site
223283010893	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
223283010894	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
223283010895	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
223283010896	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
223283010897	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
223283010898	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
223283010899	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
223283010900	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
223283010901	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
223283010902	PYR/PP interface [polypeptide binding]; other site
223283010903	dimer interface [polypeptide binding]; other site
223283010904	TPP binding site [chemical binding]; other site
223283010905	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
223283010906	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
223283010907	TPP-binding site; other site
223283010908	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
223283010909	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
223283010910	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
223283010911	tetrameric interface [polypeptide binding]; other site
223283010912	NAD binding site [chemical binding]; other site
223283010913	catalytic residues [active]
223283010914	KduI/IolB family; Region: KduI; cl01508
223283010915	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
223283010916	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
223283010917	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
223283010918	substrate binding site [chemical binding]; other site
223283010919	ATP binding site [chemical binding]; other site
223283010920	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
223283010921	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
223283010922	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
223283010923	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
223283010924	putative active site [active]
223283010925	Predicted integral membrane protein [Function unknown]; Region: COG0392
223283010926	cardiolipin synthase 2; Provisional; Region: PRK11263
223283010927	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
223283010928	putative active site [active]
223283010929	catalytic site [active]
223283010930	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
223283010931	putative active site [active]
223283010932	catalytic site [active]
223283010933	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
223283010934	putative catalytic site [active]
223283010935	putative metal binding site [ion binding]; other site
223283010936	putative phosphate binding site [ion binding]; other site
223283010937	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
223283010938	5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136
223283010939	beta-hexosaminidase; Provisional; Region: PRK05337
223283010940	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
223283010941	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283010942	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283010943	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
223283010944	LexA repressor; Validated; Region: PRK00215
223283010945	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
223283010946	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
223283010947	Catalytic site [active]
223283010948	Cell division inhibitor SulA; Region: SulA; cl01880
223283010949	enoyl-CoA hydratase; Provisional; Region: PRK06688
223283010950	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
223283010951	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
223283010952	active site
223283010953	interdomain interaction site; other site
223283010954	putative metal-binding site [ion binding]; other site
223283010955	nucleotide binding site [chemical binding]; other site
223283010956	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
223283010957	domain I; other site
223283010958	DNA binding groove [nucleotide binding]
223283010959	phosphate binding site [ion binding]; other site
223283010960	domain II; other site
223283010961	domain III; other site
223283010962	nucleotide binding site [chemical binding]; other site
223283010963	catalytic site [active]
223283010964	domain IV; other site
223283010965	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
223283010966	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
223283010967	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
223283010968	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
223283010969	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
223283010970	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
223283010971	dimer interface [polypeptide binding]; other site
223283010972	active site
223283010973	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
223283010974	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
223283010975	substrate binding site [chemical binding]; other site
223283010976	oxyanion hole (OAH) forming residues; other site
223283010977	trimer interface [polypeptide binding]; other site
223283010978	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
223283010979	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
223283010980	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
223283010981	Ligand Binding Site [chemical binding]; other site
223283010982	ABC transporter ATPase component; Reviewed; Region: PRK11147
223283010983	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
223283010984	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
223283010985	ABC transporter; Region: ABC_tran_2; pfam12848
223283010986	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
223283010987	lytic murein transglycosylase; Provisional; Region: PRK11619
223283010988	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283010989	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283010990	catalytic residue [active]
223283010991	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
223283010992	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
223283010993	MOSC domain; Region: MOSC; pfam03473
223283010994	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
223283010995	Response regulator receiver domain; Region: Response_reg; pfam00072
223283010996	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283010997	active site
223283010998	phosphorylation site [posttranslational modification]
223283010999	intermolecular recognition site; other site
223283011000	dimerization interface [polypeptide binding]; other site
223283011001	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283011002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283011003	active site
223283011004	phosphorylation site [posttranslational modification]
223283011005	intermolecular recognition site; other site
223283011006	dimerization interface [polypeptide binding]; other site
223283011007	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283011008	DNA binding residues [nucleotide binding]
223283011009	lipid kinase; Reviewed; Region: PRK13054
223283011010	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
223283011011	Transposase domain (DUF772); Region: DUF772; pfam05598
223283011012	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283011013	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
223283011014	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283011015	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
223283011016	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
223283011017	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
223283011018	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
223283011019	Substrate binding site; other site
223283011020	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
223283011021	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
223283011022	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
223283011023	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
223283011024	Chain length determinant protein; Region: Wzz; cl15801
223283011025	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283011026	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
223283011027	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
223283011028	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
223283011029	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
223283011030	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283011031	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
223283011032	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
223283011033	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
223283011034	trimer interface [polypeptide binding]; other site
223283011035	active site
223283011036	substrate binding site [chemical binding]; other site
223283011037	CoA binding site [chemical binding]; other site
223283011038	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
223283011039	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
223283011040	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
223283011041	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283011042	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
223283011043	putative dimerization interface [polypeptide binding]; other site
223283011044	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
223283011045	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
223283011046	gating phenylalanine in ion channel; other site
223283011047	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
223283011048	active site
223283011049	catalytic residues [active]
223283011050	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
223283011051	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
223283011052	potential catalytic triad [active]
223283011053	conserved cys residue [active]
223283011054	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283011055	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283011056	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
223283011057	substrate binding pocket [chemical binding]; other site
223283011058	dimerization interface [polypeptide binding]; other site
223283011059	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
223283011060	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
223283011061	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283011062	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283011063	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
223283011064	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
223283011065	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
223283011066	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
223283011067	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
223283011068	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
223283011069	Transcriptional regulator [Transcription]; Region: IclR; COG1414
223283011070	Bacterial transcriptional regulator; Region: IclR; pfam01614
223283011071	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
223283011072	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
223283011073	dimer interface [polypeptide binding]; other site
223283011074	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
223283011075	active site
223283011076	Fe binding site [ion binding]; other site
223283011077	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
223283011078	maleylacetoacetate isomerase; Region: maiA; TIGR01262
223283011079	C-terminal domain interface [polypeptide binding]; other site
223283011080	GSH binding site (G-site) [chemical binding]; other site
223283011081	putative dimer interface [polypeptide binding]; other site
223283011082	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
223283011083	dimer interface [polypeptide binding]; other site
223283011084	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
223283011085	N-terminal domain interface [polypeptide binding]; other site
223283011086	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
223283011087	FAD binding domain; Region: FAD_binding_4; pfam01565
223283011088	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
223283011089	FAD binding domain; Region: FAD_binding_4; pfam01565
223283011090	Domain of unknown function (DUF336); Region: DUF336; cl01249
223283011091	malate synthase G; Provisional; Region: PRK02999
223283011092	active site
223283011093	GDA1/CD39 (nucleoside phosphatase) family; Region: GDA1_CD39; cl17763
223283011094	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
223283011095	structural tetrad; other site
223283011096	Transcriptional regulators [Transcription]; Region: PurR; COG1609
223283011097	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
223283011098	DNA binding site [nucleotide binding]
223283011099	domain linker motif; other site
223283011100	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
223283011101	putative dimerization interface [polypeptide binding]; other site
223283011102	putative ligand binding site [chemical binding]; other site
223283011103	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
223283011104	ATP-binding site [chemical binding]; other site
223283011105	Gluconate-6-phosphate binding site [chemical binding]; other site
223283011106	GntP family permease; Region: GntP_permease; pfam02447
223283011107	fructuronate transporter; Provisional; Region: PRK10034; cl15264
223283011108	carbon storage regulator; Provisional; Region: PRK01712
223283011109	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
223283011110	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
223283011111	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
223283011112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283011113	Coenzyme A binding pocket [chemical binding]; other site
223283011114	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
223283011115	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
223283011116	putative acetyltransferase; Provisional; Region: PRK03624
223283011117	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283011118	Coenzyme A binding pocket [chemical binding]; other site
223283011119	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283011120	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283011121	N-terminal plug; other site
223283011122	ligand-binding site [chemical binding]; other site
223283011123	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
223283011124	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283011125	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283011126	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
223283011127	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283011128	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283011129	HAMP domain; Region: HAMP; pfam00672
223283011130	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283011131	dimer interface [polypeptide binding]; other site
223283011132	putative CheW interface [polypeptide binding]; other site
223283011133	SnoaL-like domain; Region: SnoaL_2; pfam12680
223283011134	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
223283011135	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
223283011136	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283011137	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283011138	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283011139	dimerization interface [polypeptide binding]; other site
223283011140	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283011141	dimer interface [polypeptide binding]; other site
223283011142	putative CheW interface [polypeptide binding]; other site
223283011143	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283011144	Coenzyme A binding pocket [chemical binding]; other site
223283011145	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
223283011146	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
223283011147	tetramer interface [polypeptide binding]; other site
223283011148	heme binding pocket [chemical binding]; other site
223283011149	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
223283011150	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
223283011151	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
223283011152	PAS fold; Region: PAS_4; pfam08448
223283011153	PAS fold; Region: PAS_4; pfam08448
223283011154	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283011155	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283011156	dimer interface [polypeptide binding]; other site
223283011157	phosphorylation site [posttranslational modification]
223283011158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283011159	ATP binding site [chemical binding]; other site
223283011160	Mg2+ binding site [ion binding]; other site
223283011161	G-X-G motif; other site
223283011162	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283011163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283011164	active site
223283011165	phosphorylation site [posttranslational modification]
223283011166	intermolecular recognition site; other site
223283011167	dimerization interface [polypeptide binding]; other site
223283011168	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283011169	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283011170	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
223283011171	dimerization interface [polypeptide binding]; other site
223283011172	Predicted membrane protein [Function unknown]; Region: COG4125
223283011173	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
223283011174	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
223283011175	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
223283011176	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
223283011177	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283011178	motif II; other site
223283011179	Predicted permeases [General function prediction only]; Region: RarD; COG2962
223283011180	Predicted ATPase [General function prediction only]; Region: COG1485
223283011181	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
223283011182	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
223283011183	Sulfate transporter family; Region: Sulfate_transp; pfam00916
223283011184	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
223283011185	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
223283011186	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
223283011187	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
223283011188	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
223283011189	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283011190	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
223283011191	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
223283011192	DNA binding site [nucleotide binding]
223283011193	active site
223283011194	Iron permease FTR1 family; Region: FTR1; cl00475
223283011195	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
223283011196	Imelysin; Region: Peptidase_M75; pfam09375
223283011197	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
223283011198	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
223283011199	Imelysin; Region: Peptidase_M75; pfam09375
223283011200	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
223283011201	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
223283011202	Moco binding site; other site
223283011203	metal coordination site [ion binding]; other site
223283011204	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
223283011205	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
223283011206	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
223283011207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283011208	active site
223283011209	phosphorylation site [posttranslational modification]
223283011210	intermolecular recognition site; other site
223283011211	dimerization interface [polypeptide binding]; other site
223283011212	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283011213	DNA binding site [nucleotide binding]
223283011214	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
223283011215	HAMP domain; Region: HAMP; pfam00672
223283011216	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283011217	dimer interface [polypeptide binding]; other site
223283011218	phosphorylation site [posttranslational modification]
223283011219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283011220	ATP binding site [chemical binding]; other site
223283011221	Mg2+ binding site [ion binding]; other site
223283011222	G-X-G motif; other site
223283011223	Alginate lyase; Region: Alginate_lyase2; pfam08787
223283011224	transposase/IS protein; Provisional; Region: PRK09183
223283011225	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283011226	Walker A motif; other site
223283011227	ATP binding site [chemical binding]; other site
223283011228	Walker B motif; other site
223283011229	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283011230	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283011231	DNA-binding interface [nucleotide binding]; DNA binding site
223283011232	Integrase core domain; Region: rve; pfam00665
223283011233	Integrase core domain; Region: rve_3; cl15866
223283011234	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
223283011235	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283011236	active site
223283011237	catalytic residues [active]
223283011238	DNA binding site [nucleotide binding]
223283011239	Int/Topo IB signature motif; other site
223283011240	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283011241	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283011242	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283011243	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283011244	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283011245	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283011246	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283011247	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283011248	active site
223283011249	catalytic residues [active]
223283011250	DNA binding site [nucleotide binding]
223283011251	Int/Topo IB signature motif; other site
223283011252	Caspase domain; Region: Peptidase_C14; pfam00656
223283011253	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
223283011254	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
223283011255	Fusaric acid resistance protein family; Region: FUSC; pfam04632
223283011256	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
223283011257	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
223283011258	HlyD family secretion protein; Region: HlyD; pfam00529
223283011259	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283011260	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283011261	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
223283011262	Ion transport protein; Region: Ion_trans; pfam00520
223283011263	Ion channel; Region: Ion_trans_2; pfam07885
223283011264	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
223283011265	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
223283011266	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
223283011267	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
223283011268	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
223283011269	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
223283011270	catalytic residues [active]
223283011271	central insert; other site
223283011272	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
223283011273	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
223283011274	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
223283011275	heme exporter protein CcmC; Region: ccmC; TIGR01191
223283011276	CcmB protein; Region: CcmB; cl17444
223283011277	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
223283011278	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
223283011279	Walker A/P-loop; other site
223283011280	ATP binding site [chemical binding]; other site
223283011281	Q-loop/lid; other site
223283011282	ABC transporter signature motif; other site
223283011283	Walker B; other site
223283011284	D-loop; other site
223283011285	H-loop/switch region; other site
223283011286	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
223283011287	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
223283011288	recombination protein RecR; Reviewed; Region: recR; PRK00076
223283011289	RecR protein; Region: RecR; pfam02132
223283011290	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
223283011291	putative active site [active]
223283011292	putative metal-binding site [ion binding]; other site
223283011293	tetramer interface [polypeptide binding]; other site
223283011294	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283011295	transcriptional activator TtdR; Provisional; Region: PRK09801
223283011296	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
223283011297	putative effector binding pocket; other site
223283011298	putative dimerization interface [polypeptide binding]; other site
223283011299	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
223283011300	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
223283011301	dimer interface [polypeptide binding]; other site
223283011302	active site
223283011303	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
223283011304	substrate binding site [chemical binding]; other site
223283011305	catalytic residue [active]
223283011306	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
223283011307	homotrimer interaction site [polypeptide binding]; other site
223283011308	putative active site [active]
223283011309	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283011310	Coenzyme A binding pocket [chemical binding]; other site
223283011311	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
223283011312	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
223283011313	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
223283011314	NAD binding site [chemical binding]; other site
223283011315	catalytic residues [active]
223283011316	hypothetical protein; Validated; Region: PRK00153
223283011317	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
223283011318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283011319	Walker A motif; other site
223283011320	ATP binding site [chemical binding]; other site
223283011321	Walker B motif; other site
223283011322	arginine finger; other site
223283011323	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
223283011324	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
223283011325	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283011326	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283011327	substrate binding pocket [chemical binding]; other site
223283011328	membrane-bound complex binding site; other site
223283011329	hinge residues; other site
223283011330	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
223283011331	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
223283011332	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
223283011333	Mechanosensitive ion channel; Region: MS_channel; pfam00924
223283011334	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283011335	AAA domain; Region: AAA_21; pfam13304
223283011336	Walker A/P-loop; other site
223283011337	ATP binding site [chemical binding]; other site
223283011338	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283011339	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283011340	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283011341	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283011342	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283011343	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283011344	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283011345	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283011346	Coenzyme A binding pocket [chemical binding]; other site
223283011347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
223283011348	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
223283011349	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
223283011350	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
223283011351	nucleotide binding pocket [chemical binding]; other site
223283011352	K-X-D-G motif; other site
223283011353	catalytic site [active]
223283011354	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
223283011355	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
223283011356	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
223283011357	Dimer interface [polypeptide binding]; other site
223283011358	BRCT sequence motif; other site
223283011359	cell division protein ZipA; Reviewed; Region: zipA; PRK00269
223283011360	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
223283011361	FtsZ protein binding site [polypeptide binding]; other site
223283011362	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
223283011363	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
223283011364	Walker A/P-loop; other site
223283011365	ATP binding site [chemical binding]; other site
223283011366	Q-loop/lid; other site
223283011367	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
223283011368	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
223283011369	ABC transporter signature motif; other site
223283011370	Walker B; other site
223283011371	D-loop; other site
223283011372	H-loop/switch region; other site
223283011373	Transcriptional regulators [Transcription]; Region: GntR; COG1802
223283011374	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283011375	DNA-binding site [nucleotide binding]; DNA binding site
223283011376	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
223283011377	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
223283011378	catalytic loop [active]
223283011379	iron binding site [ion binding]; other site
223283011380	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
223283011381	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
223283011382	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
223283011383	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
223283011384	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
223283011385	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
223283011386	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
223283011387	XdhC Rossmann domain; Region: XdhC_C; pfam13478
223283011388	guanine deaminase; Provisional; Region: PRK09228
223283011389	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
223283011390	active site
223283011391	Transcriptional regulators [Transcription]; Region: GntR; COG1802
223283011392	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283011393	DNA-binding site [nucleotide binding]; DNA binding site
223283011394	FCD domain; Region: FCD; pfam07729
223283011395	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
223283011396	active site
223283011397	homotetramer interface [polypeptide binding]; other site
223283011398	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
223283011399	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
223283011400	active site
223283011401	catalytic site [active]
223283011402	tetramer interface [polypeptide binding]; other site
223283011403	OHCU decarboxylase; Region: UHCUDC; TIGR03164
223283011404	allantoicase; Provisional; Region: PRK13257
223283011405	Allantoicase repeat; Region: Allantoicase; pfam03561
223283011406	Allantoicase repeat; Region: Allantoicase; pfam03561
223283011407	ureidoglycolate hydrolase; Provisional; Region: PRK03606
223283011408	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
223283011409	Protein of unknown function (DUF989); Region: DUF989; pfam06181
223283011410	Predicted membrane protein [Function unknown]; Region: COG3748
223283011411	Cytochrome c; Region: Cytochrom_C; pfam00034
223283011412	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
223283011413	Protein of unknown function (DUF808); Region: DUF808; pfam05661
223283011414	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
223283011415	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283011416	putative DNA binding site [nucleotide binding]; other site
223283011417	putative Zn2+ binding site [ion binding]; other site
223283011418	AsnC family; Region: AsnC_trans_reg; pfam01037
223283011419	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
223283011420	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
223283011421	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283011422	catalytic residue [active]
223283011423	Predicted transcriptional regulator [Transcription]; Region: COG3905
223283011424	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
223283011425	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283011426	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283011427	LysR substrate binding domain; Region: LysR_substrate; pfam03466
223283011428	dimerization interface [polypeptide binding]; other site
223283011429	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
223283011430	EamA-like transporter family; Region: EamA; pfam00892
223283011431	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283011432	dimerization interface [polypeptide binding]; other site
223283011433	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283011434	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283011435	dimer interface [polypeptide binding]; other site
223283011436	putative CheW interface [polypeptide binding]; other site
223283011437	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
223283011438	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
223283011439	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283011440	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283011441	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283011442	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
223283011443	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283011444	dimer interface [polypeptide binding]; other site
223283011445	putative CheW interface [polypeptide binding]; other site
223283011446	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
223283011447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283011448	putative substrate translocation pore; other site
223283011449	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
223283011450	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
223283011451	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
223283011452	HNH endonuclease; Region: HNH; pfam01844
223283011453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283011454	AAA domain; Region: AAA_21; pfam13304
223283011455	Walker A/P-loop; other site
223283011456	ATP binding site [chemical binding]; other site
223283011457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283011458	Walker B; other site
223283011459	D-loop; other site
223283011460	H-loop/switch region; other site
223283011461	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
223283011462	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283011463	N-terminal plug; other site
223283011464	ligand-binding site [chemical binding]; other site
223283011465	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
223283011466	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
223283011467	PA14 domain; Region: PA14; pfam07691
223283011468	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
223283011469	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283011470	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283011471	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
223283011472	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283011473	PAS fold; Region: PAS_3; pfam08447
223283011474	putative active site [active]
223283011475	heme pocket [chemical binding]; other site
223283011476	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
223283011477	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
223283011478	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283011479	putative active site [active]
223283011480	heme pocket [chemical binding]; other site
223283011481	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283011482	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283011483	dimer interface [polypeptide binding]; other site
223283011484	phosphorylation site [posttranslational modification]
223283011485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283011486	ATP binding site [chemical binding]; other site
223283011487	Mg2+ binding site [ion binding]; other site
223283011488	G-X-G motif; other site
223283011489	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283011490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283011491	active site
223283011492	phosphorylation site [posttranslational modification]
223283011493	intermolecular recognition site; other site
223283011494	dimerization interface [polypeptide binding]; other site
223283011495	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
223283011496	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283011497	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
223283011498	Cache domain; Region: Cache_2; pfam08269
223283011499	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283011500	dimerization interface [polypeptide binding]; other site
223283011501	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283011502	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283011503	dimer interface [polypeptide binding]; other site
223283011504	putative CheW interface [polypeptide binding]; other site
223283011505	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
223283011506	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
223283011507	active site
223283011508	catalytic tetrad [active]
223283011509	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
223283011510	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
223283011511	Cl binding site [ion binding]; other site
223283011512	oligomer interface [polypeptide binding]; other site
223283011513	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
223283011514	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
223283011515	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
223283011516	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283011517	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283011518	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
223283011519	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283011520	putative substrate translocation pore; other site
223283011521	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
223283011522	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
223283011523	substrate binding site [chemical binding]; other site
223283011524	oxyanion hole (OAH) forming residues; other site
223283011525	trimer interface [polypeptide binding]; other site
223283011526	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
223283011527	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
223283011528	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
223283011529	active site
223283011530	Peptidase M35 family; Region: M35_like; cl03449
223283011531	active site
223283011532	Zn binding site [ion binding]; other site
223283011533	Predicted flavoprotein [General function prediction only]; Region: COG0431
223283011534	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
223283011535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283011536	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
223283011537	Coenzyme A binding pocket [chemical binding]; other site
223283011538	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
223283011539	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
223283011540	active site
223283011541	catalytic site [active]
223283011542	substrate binding site [chemical binding]; other site
223283011543	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
223283011544	RNA/DNA hybrid binding site [nucleotide binding]; other site
223283011545	active site
223283011546	Methyltransferase domain; Region: Methyltransf_23; pfam13489
223283011547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
223283011548	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
223283011549	MltD lipid attachment motif; Region: MLTD_N; pfam06474
223283011550	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
223283011551	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283011552	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283011553	catalytic residue [active]
223283011554	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
223283011555	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
223283011556	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
223283011557	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
223283011558	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
223283011559	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
223283011560	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
223283011561	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
223283011562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283011563	dimer interface [polypeptide binding]; other site
223283011564	conserved gate region; other site
223283011565	putative PBP binding loops; other site
223283011566	ABC-ATPase subunit interface; other site
223283011567	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
223283011568	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283011569	dimer interface [polypeptide binding]; other site
223283011570	conserved gate region; other site
223283011571	putative PBP binding loops; other site
223283011572	ABC-ATPase subunit interface; other site
223283011573	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
223283011574	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283011575	Walker A/P-loop; other site
223283011576	ATP binding site [chemical binding]; other site
223283011577	Q-loop/lid; other site
223283011578	ABC transporter signature motif; other site
223283011579	Walker B; other site
223283011580	D-loop; other site
223283011581	H-loop/switch region; other site
223283011582	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
223283011583	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283011584	Walker A/P-loop; other site
223283011585	ATP binding site [chemical binding]; other site
223283011586	Q-loop/lid; other site
223283011587	ABC transporter signature motif; other site
223283011588	Walker B; other site
223283011589	D-loop; other site
223283011590	H-loop/switch region; other site
223283011591	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283011592	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
223283011593	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
223283011594	NAD binding site [chemical binding]; other site
223283011595	homotetramer interface [polypeptide binding]; other site
223283011596	homodimer interface [polypeptide binding]; other site
223283011597	substrate binding site [chemical binding]; other site
223283011598	active site
223283011599	periplasmic folding chaperone; Provisional; Region: PRK10788
223283011600	SurA N-terminal domain; Region: SurA_N_3; pfam13624
223283011601	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
223283011602	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
223283011603	IHF - DNA interface [nucleotide binding]; other site
223283011604	IHF dimer interface [polypeptide binding]; other site
223283011605	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
223283011606	Found in ATP-dependent protease La (LON); Region: LON; smart00464
223283011607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283011608	Walker A motif; other site
223283011609	ATP binding site [chemical binding]; other site
223283011610	Walker B motif; other site
223283011611	arginine finger; other site
223283011612	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
223283011613	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
223283011614	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
223283011615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283011616	Walker A motif; other site
223283011617	ATP binding site [chemical binding]; other site
223283011618	Walker B motif; other site
223283011619	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
223283011620	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
223283011621	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
223283011622	oligomer interface [polypeptide binding]; other site
223283011623	active site residues [active]
223283011624	trigger factor; Provisional; Region: tig; PRK01490
223283011625	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
223283011626	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
223283011627	Transposase domain (DUF772); Region: DUF772; pfam05598
223283011628	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283011629	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283011630	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
223283011631	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
223283011632	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
223283011633	homodimer interface [polypeptide binding]; other site
223283011634	NADP binding site [chemical binding]; other site
223283011635	substrate binding site [chemical binding]; other site
223283011636	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283011637	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283011638	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283011639	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
223283011640	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
223283011641	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
223283011642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283011643	dimer interface [polypeptide binding]; other site
223283011644	conserved gate region; other site
223283011645	putative PBP binding loops; other site
223283011646	ABC-ATPase subunit interface; other site
223283011647	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
223283011648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283011649	dimer interface [polypeptide binding]; other site
223283011650	conserved gate region; other site
223283011651	putative PBP binding loops; other site
223283011652	ABC-ATPase subunit interface; other site
223283011653	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
223283011654	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
223283011655	Walker A/P-loop; other site
223283011656	ATP binding site [chemical binding]; other site
223283011657	Q-loop/lid; other site
223283011658	ABC transporter signature motif; other site
223283011659	Walker B; other site
223283011660	D-loop; other site
223283011661	H-loop/switch region; other site
223283011662	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
223283011663	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
223283011664	Walker A/P-loop; other site
223283011665	ATP binding site [chemical binding]; other site
223283011666	Q-loop/lid; other site
223283011667	ABC transporter signature motif; other site
223283011668	Walker B; other site
223283011669	D-loop; other site
223283011670	H-loop/switch region; other site
223283011671	TOBE domain; Region: TOBE_2; pfam08402
223283011672	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
223283011673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283011674	Walker A motif; other site
223283011675	ATP binding site [chemical binding]; other site
223283011676	Walker B motif; other site
223283011677	arginine finger; other site
223283011678	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283011679	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
223283011680	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
223283011681	active site
223283011682	HIGH motif; other site
223283011683	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
223283011684	KMSKS motif; other site
223283011685	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
223283011686	tRNA binding surface [nucleotide binding]; other site
223283011687	anticodon binding site; other site
223283011688	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
223283011689	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
223283011690	active site
223283011691	HIGH motif; other site
223283011692	nucleotide binding site [chemical binding]; other site
223283011693	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
223283011694	KMSKS motif; other site
223283011695	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
223283011696	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
223283011697	substrate binding site [chemical binding]; other site
223283011698	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
223283011699	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
223283011700	putative active site [active]
223283011701	putative metal binding site [ion binding]; other site
223283011702	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
223283011703	Transposase; Region: DEDD_Tnp_IS110; pfam01548
223283011704	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
223283011705	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
223283011706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283011707	putative substrate translocation pore; other site
223283011708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283011709	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
223283011710	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283011711	Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654
223283011712	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283011713	MarR family; Region: MarR_2; cl17246
223283011714	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
223283011715	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
223283011716	active site
223283011717	dinuclear metal binding site [ion binding]; other site
223283011718	dimerization interface [polypeptide binding]; other site
223283011719	Predicted Fe-S protein [General function prediction only]; Region: COG3313
223283011720	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
223283011721	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
223283011722	substrate binding site [chemical binding]; other site
223283011723	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
223283011724	substrate binding site [chemical binding]; other site
223283011725	ligand binding site [chemical binding]; other site
223283011726	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283011727	putative active site [active]
223283011728	heme pocket [chemical binding]; other site
223283011729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283011730	PAS domain; Region: PAS_9; pfam13426
223283011731	putative active site [active]
223283011732	heme pocket [chemical binding]; other site
223283011733	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283011734	dimer interface [polypeptide binding]; other site
223283011735	putative CheW interface [polypeptide binding]; other site
223283011736	Predicted membrane protein [Function unknown]; Region: COG1971
223283011737	Domain of unknown function DUF; Region: DUF204; pfam02659
223283011738	Domain of unknown function DUF; Region: DUF204; pfam02659
223283011739	Uncharacterized conserved protein [Function unknown]; Region: COG4104
223283011740	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
223283011741	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
223283011742	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
223283011743	active site
223283011744	MoxR-like ATPases [General function prediction only]; Region: COG0714
223283011745	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283011746	Walker A motif; other site
223283011747	ATP binding site [chemical binding]; other site
223283011748	Walker B motif; other site
223283011749	arginine finger; other site
223283011750	Protein of unknown function DUF58; Region: DUF58; pfam01882
223283011751	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
223283011752	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
223283011753	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
223283011754	metal ion-dependent adhesion site (MIDAS); other site
223283011755	von Willebrand factor type A domain; Region: VWA_2; pfam13519
223283011756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283011757	Tetratricopeptide repeat; Region: TPR_16; pfam13432
223283011758	TPR motif; other site
223283011759	binding surface
223283011760	Oxygen tolerance; Region: BatD; pfam13584
223283011761	exonuclease subunit SbcD; Provisional; Region: PRK10966
223283011762	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
223283011763	active site
223283011764	metal binding site [ion binding]; metal-binding site
223283011765	DNA binding site [nucleotide binding]
223283011766	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
223283011767	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283011768	AAA domain; Region: AAA_23; pfam13476
223283011769	Walker A/P-loop; other site
223283011770	ATP binding site [chemical binding]; other site
223283011771	Q-loop/lid; other site
223283011772	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283011773	ABC transporter signature motif; other site
223283011774	Walker B; other site
223283011775	D-loop; other site
223283011776	H-loop/switch region; other site
223283011777	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
223283011778	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
223283011779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
223283011780	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
223283011781	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
223283011782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283011783	putative substrate translocation pore; other site
223283011784	dihydroxy-acid dehydratase; Validated; Region: PRK06131
223283011785	Transcriptional regulators [Transcription]; Region: FadR; COG2186
223283011786	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283011787	DNA-binding site [nucleotide binding]; DNA binding site
223283011788	FCD domain; Region: FCD; pfam07729
223283011789	PAAR motif; Region: PAAR_motif; pfam05488
223283011790	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
223283011791	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
223283011792	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
223283011793	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
223283011794	Protein of unknown function (DUF1190); Region: DUF1190; pfam06693
223283011795	Predicted membrane protein [Function unknown]; Region: COG3766
223283011796	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
223283011797	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
223283011798	Ion channel; Region: Ion_trans_2; pfam07885
223283011799	TrkA-N domain; Region: TrkA_N; pfam02254
223283011800	Rhomboid family; Region: Rhomboid; cl11446
223283011801	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
223283011802	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
223283011803	aminopeptidase N; Provisional; Region: pepN; PRK14015
223283011804	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
223283011805	active site
223283011806	Zn binding site [ion binding]; other site
223283011807	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
223283011808	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
223283011809	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
223283011810	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
223283011811	active site
223283011812	metal binding site [ion binding]; metal-binding site
223283011813	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
223283011814	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
223283011815	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283011816	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283011817	metal binding site [ion binding]; metal-binding site
223283011818	active site
223283011819	I-site; other site
223283011820	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
223283011821	arsenical pump membrane protein; Provisional; Region: PRK15445
223283011822	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
223283011823	transmembrane helices; other site
223283011824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283011825	putative substrate translocation pore; other site
223283011826	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283011827	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
223283011828	Transposase; Region: DEDD_Tnp_IS110; pfam01548
223283011829	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
223283011830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283011831	metabolite-proton symporter; Region: 2A0106; TIGR00883
223283011832	putative substrate translocation pore; other site
223283011833	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
223283011834	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
223283011835	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283011836	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
223283011837	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
223283011838	active site
223283011839	FMN binding site [chemical binding]; other site
223283011840	2,4-decadienoyl-CoA binding site; other site
223283011841	catalytic residue [active]
223283011842	4Fe-4S cluster binding site [ion binding]; other site
223283011843	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
223283011844	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283011845	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
223283011846	active site
223283011847	catalytic triad [active]
223283011848	Predicted amidohydrolase [General function prediction only]; Region: COG0388
223283011849	dimer interface [polypeptide binding]; other site
223283011850	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
223283011851	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
223283011852	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283011853	threonine dehydratase; Reviewed; Region: PRK09224
223283011854	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
223283011855	tetramer interface [polypeptide binding]; other site
223283011856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283011857	catalytic residue [active]
223283011858	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
223283011859	putative Ile/Val binding site [chemical binding]; other site
223283011860	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
223283011861	putative Ile/Val binding site [chemical binding]; other site
223283011862	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
223283011863	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283011864	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283011865	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283011866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283011867	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
223283011868	NAD(P) binding site [chemical binding]; other site
223283011869	active site
223283011870	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
223283011871	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
223283011872	homodimer interface [polypeptide binding]; other site
223283011873	substrate-cofactor binding pocket; other site
223283011874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283011875	catalytic residue [active]
223283011876	amidophosphoribosyltransferase; Provisional; Region: PRK09246
223283011877	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
223283011878	active site
223283011879	tetramer interface [polypeptide binding]; other site
223283011880	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
223283011881	active site
223283011882	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
223283011883	Colicin V production protein; Region: Colicin_V; cl00567
223283011884	Sporulation related domain; Region: SPOR; pfam05036
223283011885	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
223283011886	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
223283011887	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
223283011888	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
223283011889	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
223283011890	active site
223283011891	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
223283011892	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
223283011893	dimerization interface 3.5A [polypeptide binding]; other site
223283011894	active site
223283011895	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
223283011896	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
223283011897	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671
223283011898	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
223283011899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
223283011900	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
223283011901	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
223283011902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283011903	LysE type translocator; Region: LysE; pfam01810
223283011904	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
223283011905	active site
223283011906	PilZ domain; Region: PilZ; cl01260
223283011907	DNA polymerase III subunit delta'; Validated; Region: PRK05707
223283011908	DNA polymerase III subunit delta'; Validated; Region: PRK08485
223283011909	thymidylate kinase; Validated; Region: tmk; PRK00698
223283011910	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
223283011911	TMP-binding site; other site
223283011912	ATP-binding site [chemical binding]; other site
223283011913	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
223283011914	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
223283011915	dimerization interface [polypeptide binding]; other site
223283011916	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
223283011917	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
223283011918	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283011919	catalytic residue [active]
223283011920	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
223283011921	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
223283011922	dimer interface [polypeptide binding]; other site
223283011923	active site
223283011924	acyl carrier protein; Provisional; Region: acpP; PRK00982
223283011925	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
223283011926	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
223283011927	NAD(P) binding site [chemical binding]; other site
223283011928	homotetramer interface [polypeptide binding]; other site
223283011929	homodimer interface [polypeptide binding]; other site
223283011930	active site
223283011931	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
223283011932	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
223283011933	putative phosphate acyltransferase; Provisional; Region: PRK05331
223283011934	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
223283011935	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
223283011936	Maf-like protein; Region: Maf; pfam02545
223283011937	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
223283011938	active site
223283011939	dimer interface [polypeptide binding]; other site
223283011940	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
223283011941	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
223283011942	tandem repeat interface [polypeptide binding]; other site
223283011943	oligomer interface [polypeptide binding]; other site
223283011944	active site residues [active]
223283011945	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
223283011946	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283011947	motif II; other site
223283011948	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
223283011949	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
223283011950	RNA binding surface [nucleotide binding]; other site
223283011951	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
223283011952	active site
223283011953	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
223283011954	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
223283011955	homodimer interface [polypeptide binding]; other site
223283011956	oligonucleotide binding site [chemical binding]; other site
223283011957	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
223283011958	FAD binding domain; Region: FAD_binding_4; pfam01565
223283011959	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
223283011960	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
223283011961	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
223283011962	Ligand binding site; other site
223283011963	oligomer interface; other site
223283011964	Uncharacterized conserved protein [Function unknown]; Region: COG2835
223283011965	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
223283011966	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
223283011967	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
223283011968	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
223283011969	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
223283011970	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
223283011971	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
223283011972	Competence protein; Region: Competence; pfam03772
223283011973	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
223283011974	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
223283011975	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
223283011976	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
223283011977	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
223283011978	inner membrane transport permease; Provisional; Region: PRK15066
223283011979	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
223283011980	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
223283011981	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283011982	Walker A/P-loop; other site
223283011983	ATP binding site [chemical binding]; other site
223283011984	Q-loop/lid; other site
223283011985	ABC transporter signature motif; other site
223283011986	Walker B; other site
223283011987	D-loop; other site
223283011988	H-loop/switch region; other site
223283011989	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
223283011990	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
223283011991	putative C-terminal domain interface [polypeptide binding]; other site
223283011992	putative GSH binding site (G-site) [chemical binding]; other site
223283011993	putative dimer interface [polypeptide binding]; other site
223283011994	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
223283011995	putative N-terminal domain interface [polypeptide binding]; other site
223283011996	putative dimer interface [polypeptide binding]; other site
223283011997	putative substrate binding pocket (H-site) [chemical binding]; other site
223283011998	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
223283011999	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
223283012000	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
223283012001	active site
223283012002	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
223283012003	Pirin-related protein [General function prediction only]; Region: COG1741
223283012004	Pirin; Region: Pirin; pfam02678
223283012005	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
223283012006	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
223283012007	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
223283012008	dimer interface [polypeptide binding]; other site
223283012009	TPP-binding site [chemical binding]; other site
223283012010	MarR family; Region: MarR_2; pfam12802
223283012011	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
223283012012	Autoinducer binding domain; Region: Autoind_bind; pfam03472
223283012013	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283012014	DNA binding residues [nucleotide binding]
223283012015	dimerization interface [polypeptide binding]; other site
223283012016	Autoinducer synthetase; Region: Autoind_synth; cl17404
223283012017	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
223283012018	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283012019	catalytic residue [active]
223283012020	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
223283012021	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
223283012022	inhibitor site; inhibition site
223283012023	active site
223283012024	dimer interface [polypeptide binding]; other site
223283012025	catalytic residue [active]
223283012026	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
223283012027	iron-sulfur cluster [ion binding]; other site
223283012028	[2Fe-2S] cluster binding site [ion binding]; other site
223283012029	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
223283012030	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
223283012031	active site
223283012032	nucleophile elbow; other site
223283012033	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
223283012034	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
223283012035	putative acyl-acceptor binding pocket; other site
223283012036	septum formation inhibitor; Reviewed; Region: minC; PRK00339
223283012037	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
223283012038	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
223283012039	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
223283012040	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
223283012041	Switch I; other site
223283012042	Switch II; other site
223283012043	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
223283012044	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
223283012045	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
223283012046	active site
223283012047	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
223283012048	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
223283012049	active site
223283012050	metal binding site [ion binding]; metal-binding site
223283012051	transcriptional regulator protein; Region: phnR; TIGR03337
223283012052	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283012053	DNA-binding site [nucleotide binding]; DNA binding site
223283012054	UTRA domain; Region: UTRA; pfam07702
223283012055	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
223283012056	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
223283012057	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
223283012058	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
223283012059	BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463
223283012060	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
223283012061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283012062	dimer interface [polypeptide binding]; other site
223283012063	conserved gate region; other site
223283012064	putative PBP binding loops; other site
223283012065	ABC-ATPase subunit interface; other site
223283012066	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
223283012067	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283012068	dimer interface [polypeptide binding]; other site
223283012069	conserved gate region; other site
223283012070	ABC-ATPase subunit interface; other site
223283012071	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
223283012072	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283012073	Walker A/P-loop; other site
223283012074	ATP binding site [chemical binding]; other site
223283012075	Q-loop/lid; other site
223283012076	ABC transporter signature motif; other site
223283012077	Walker B; other site
223283012078	D-loop; other site
223283012079	H-loop/switch region; other site
223283012080	TOBE domain; Region: TOBE_2; pfam08402
223283012081	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
223283012082	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
223283012083	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
223283012084	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
223283012085	NAD(P) binding site [chemical binding]; other site
223283012086	carboxy-terminal protease; Provisional; Region: PRK11186
223283012087	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
223283012088	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
223283012089	protein binding site [polypeptide binding]; other site
223283012090	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
223283012091	Catalytic dyad [active]
223283012092	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
223283012093	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283012094	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
223283012095	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283012096	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283012097	metal binding site [ion binding]; metal-binding site
223283012098	active site
223283012099	I-site; other site
223283012100	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283012101	non-specific DNA binding site [nucleotide binding]; other site
223283012102	salt bridge; other site
223283012103	sequence-specific DNA binding site [nucleotide binding]; other site
223283012104	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
223283012105	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
223283012106	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
223283012107	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
223283012108	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
223283012109	Cupin domain; Region: Cupin_2; cl17218
223283012110	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
223283012111	dimer interface [polypeptide binding]; other site
223283012112	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
223283012113	metal binding site [ion binding]; metal-binding site
223283012114	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
223283012115	CoA-transferase family III; Region: CoA_transf_3; pfam02515
223283012116	recombination associated protein; Reviewed; Region: rdgC; PRK00321
223283012117	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
223283012118	Sodium Bile acid symporter family; Region: SBF; cl17470
223283012119	H+ Antiporter protein; Region: 2A0121; TIGR00900
223283012120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283012121	putative substrate translocation pore; other site
223283012122	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
223283012123	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
223283012124	putative acyl-acceptor binding pocket; other site
223283012125	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
223283012126	Na binding site [ion binding]; other site
223283012127	PAS domain; Region: PAS; smart00091
223283012128	PAS fold; Region: PAS_7; pfam12860
223283012129	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283012130	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283012131	dimer interface [polypeptide binding]; other site
223283012132	phosphorylation site [posttranslational modification]
223283012133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283012134	ATP binding site [chemical binding]; other site
223283012135	Mg2+ binding site [ion binding]; other site
223283012136	G-X-G motif; other site
223283012137	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
223283012138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283012139	active site
223283012140	phosphorylation site [posttranslational modification]
223283012141	intermolecular recognition site; other site
223283012142	dimerization interface [polypeptide binding]; other site
223283012143	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
223283012144	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
223283012145	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
223283012146	dimer interface [polypeptide binding]; other site
223283012147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283012148	catalytic residue [active]
223283012149	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
223283012150	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
223283012151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283012152	Walker A motif; other site
223283012153	ATP binding site [chemical binding]; other site
223283012154	Walker B motif; other site
223283012155	arginine finger; other site
223283012156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
223283012157	WbqC-like protein family; Region: WbqC; pfam08889
223283012158	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
223283012159	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
223283012160	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
223283012161	putative active site [active]
223283012162	putative dimer interface [polypeptide binding]; other site
223283012163	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
223283012164	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
223283012165	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
223283012166	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
223283012167	ligand binding site [chemical binding]; other site
223283012168	flexible hinge region; other site
223283012169	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
223283012170	active site
223283012171	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
223283012172	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
223283012173	Multicopper oxidase; Region: Cu-oxidase; pfam00394
223283012174	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
223283012175	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
223283012176	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
223283012177	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
223283012178	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
223283012179	hypothetical protein; Provisional; Region: PRK05170
223283012180	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
223283012181	putative FMN binding site [chemical binding]; other site
223283012182	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
223283012183	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
223283012184	NAD binding site [chemical binding]; other site
223283012185	ligand binding site [chemical binding]; other site
223283012186	catalytic site [active]
223283012187	YcgL domain; Region: YcgL; cl01189
223283012188	ribonuclease D; Region: rnd; TIGR01388
223283012189	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
223283012190	catalytic site [active]
223283012191	putative active site [active]
223283012192	putative substrate binding site [chemical binding]; other site
223283012193	HRDC domain; Region: HRDC; pfam00570
223283012194	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
223283012195	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
223283012196	Sulfatase; Region: Sulfatase; pfam00884
223283012197	malate dehydrogenase; Provisional; Region: PRK13529
223283012198	Malic enzyme, N-terminal domain; Region: malic; pfam00390
223283012199	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
223283012200	NAD(P) binding site [chemical binding]; other site
223283012201	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
223283012202	non-specific DNA binding site [nucleotide binding]; other site
223283012203	salt bridge; other site
223283012204	sequence-specific DNA binding site [nucleotide binding]; other site
223283012205	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
223283012206	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
223283012207	DNA-binding site [nucleotide binding]; DNA binding site
223283012208	RNA-binding motif; other site
223283012209	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
223283012210	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
223283012211	putative active site [active]
223283012212	putative NTP binding site [chemical binding]; other site
223283012213	putative nucleic acid binding site [nucleotide binding]; other site
223283012214	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
223283012215	PHAGE04; putative prophage; defective prophage region; integrase nearby, but likely a Shufflon recombinase for pillin phase variation. Several hypotheticals near shufflon recombinase - pili?
223283012216	Predicted chitinase [General function prediction only]; Region: COG3179
223283012217	catalytic residue [active]
223283012218	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
223283012219	Global regulator protein family; Region: CsrA; pfam02599
223283012220	HNH endonuclease; Region: HNH_3; pfam13392
223283012221	Rci recombinase, C-terminal catalytic domain.  Rci enzymes are found in IncI1 incompatibility group plasmids such as R64.  These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796
223283012222	catalytic residues [active]
223283012223	Int/Topo IB signature motif; other site
223283012224	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
223283012225	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
223283012226	ATP binding site [chemical binding]; other site
223283012227	active site
223283012228	substrate binding site [chemical binding]; other site
223283012229	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
223283012230	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
223283012231	dihydrodipicolinate synthase; Region: dapA; TIGR00674
223283012232	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
223283012233	dimer interface [polypeptide binding]; other site
223283012234	active site
223283012235	catalytic residue [active]
223283012236	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
223283012237	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
223283012238	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
223283012239	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
223283012240	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
223283012241	catalytic triad [active]
223283012242	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
223283012243	Domain of unknown function DUF20; Region: UPF0118; pfam01594
223283012244	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
223283012245	CPxP  motif; other site
223283012246	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
223283012247	Peptidase family M48; Region: Peptidase_M48; cl12018
223283012248	quinolinate synthetase; Provisional; Region: PRK09375
223283012249	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
223283012250	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
223283012251	Transposase domain (DUF772); Region: DUF772; pfam05598
223283012252	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283012253	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283012254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283012255	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283012256	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
223283012257	Ligand Binding Site [chemical binding]; other site
223283012258	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
223283012259	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283012260	FeS/SAM binding site; other site
223283012261	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
223283012262	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283012263	binding surface
223283012264	TPR motif; other site
223283012265	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
223283012266	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
223283012267	ligand binding site [chemical binding]; other site
223283012268	translocation protein TolB; Provisional; Region: tolB; PRK00178
223283012269	TolB amino-terminal domain; Region: TolB_N; pfam04052
223283012270	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
223283012271	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
223283012272	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
223283012273	TolA protein; Region: tolA_full; TIGR02794
223283012274	TolA protein; Region: tolA_full; TIGR02794
223283012275	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
223283012276	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
223283012277	TolR protein; Region: tolR; TIGR02801
223283012278	TolQ protein; Region: tolQ; TIGR02796
223283012279	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
223283012280	active site
223283012281	Holliday junction DNA helicase, RuvB subunit; Region: ruvB; TIGR00635
223283012282	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283012283	Walker A motif; other site
223283012284	ATP binding site [chemical binding]; other site
223283012285	Walker B motif; other site
223283012286	arginine finger; other site
223283012287	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
223283012288	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
223283012289	RuvA N terminal domain; Region: RuvA_N; pfam01330
223283012290	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
223283012291	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
223283012292	active site
223283012293	putative DNA-binding cleft [nucleotide binding]; other site
223283012294	dimer interface [polypeptide binding]; other site
223283012295	hypothetical protein; Validated; Region: PRK00110
223283012296	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
223283012297	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
223283012298	dimer interface [polypeptide binding]; other site
223283012299	anticodon binding site; other site
223283012300	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
223283012301	homodimer interface [polypeptide binding]; other site
223283012302	motif 1; other site
223283012303	active site
223283012304	motif 2; other site
223283012305	GAD domain; Region: GAD; pfam02938
223283012306	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
223283012307	active site
223283012308	motif 3; other site
223283012309	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
223283012310	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
223283012311	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
223283012312	dimerization interface [polypeptide binding]; other site
223283012313	DPS ferroxidase diiron center [ion binding]; other site
223283012314	ion pore; other site
223283012315	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
223283012316	DNA-binding site [nucleotide binding]; DNA binding site
223283012317	RNA-binding motif; other site
223283012318	hypothetical protein; Provisional; Region: PRK00295
223283012319	HIT domain; Region: HIT; pfam01230
223283012320	nucleotide binding site/active site [active]
223283012321	HIT family signature motif; other site
223283012322	catalytic residue [active]
223283012323	outer membrane porin, OprD family; Region: OprD; pfam03573
223283012324	prolyl-tRNA synthetase; Provisional; Region: PRK09194
223283012325	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
223283012326	dimer interface [polypeptide binding]; other site
223283012327	motif 1; other site
223283012328	active site
223283012329	motif 2; other site
223283012330	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
223283012331	putative deacylase active site [active]
223283012332	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
223283012333	active site
223283012334	motif 3; other site
223283012335	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
223283012336	anticodon binding site; other site
223283012337	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
223283012338	active site
223283012339	DNA polymerase IV; Validated; Region: PRK02406
223283012340	DNA binding site [nucleotide binding]
223283012341	Predicted integral membrane protein [Function unknown]; Region: COG0392
223283012342	Uncharacterized conserved protein [Function unknown]; Region: COG2898
223283012343	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
223283012344	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
223283012345	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
223283012346	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
223283012347	potassium uptake protein; Region: kup; TIGR00794
223283012348	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
223283012349	putative heme binding pocket [chemical binding]; other site
223283012350	AAA domain; Region: AAA_21; pfam13304
223283012351	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283012352	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283012353	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283012354	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283012355	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283012356	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283012357	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283012358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283012359	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283012360	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283012361	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283012362	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283012363	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283012364	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283012365	Central core of the bacterial effector protein AvrPto; Region: AvrPto; pfam11592
223283012366	PHAGE05; putative prophage; defective prophage region. AvrPto nearby, but also many Tn genes.
223283012367	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
223283012368	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
223283012369	Cro; Region: Cro; pfam09048
223283012370	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
223283012371	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283012372	non-specific DNA binding site [nucleotide binding]; other site
223283012373	sequence-specific DNA binding site [nucleotide binding]; other site
223283012374	salt bridge; other site
223283012375	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
223283012376	Catalytic site [active]
223283012377	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283012378	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283012379	DNA-binding interface [nucleotide binding]; DNA binding site
223283012380	Integrase core domain; Region: rve; pfam00665
223283012381	Integrase core domain; Region: rve_3; cl15866
223283012382	transposase/IS protein; Provisional; Region: PRK09183
223283012383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283012384	Walker A motif; other site
223283012385	ATP binding site [chemical binding]; other site
223283012386	Walker B motif; other site
223283012387	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
223283012388	catalytic residues [active]
223283012389	catalytic nucleophile [active]
223283012390	Recombinase; Region: Recombinase; pfam07508
223283012391	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
223283012392	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
223283012393	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283012394	FeS/SAM binding site; other site
223283012395	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
223283012396	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283012397	Coenzyme A binding pocket [chemical binding]; other site
223283012398	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
223283012399	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
223283012400	RNA binding surface [nucleotide binding]; other site
223283012401	Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555
223283012402	active site
223283012403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
223283012404	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
223283012405	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
223283012406	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
223283012407	homodimer interaction site [polypeptide binding]; other site
223283012408	cofactor binding site; other site
223283012409	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
223283012410	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
223283012411	FAD binding pocket [chemical binding]; other site
223283012412	FAD binding motif [chemical binding]; other site
223283012413	phosphate binding motif [ion binding]; other site
223283012414	beta-alpha-beta structure motif; other site
223283012415	NAD binding pocket [chemical binding]; other site
223283012416	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
223283012417	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283012418	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
223283012419	putative dimerization interface [polypeptide binding]; other site
223283012420	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
223283012421	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283012422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283012423	active site
223283012424	phosphorylation site [posttranslational modification]
223283012425	intermolecular recognition site; other site
223283012426	dimerization interface [polypeptide binding]; other site
223283012427	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283012428	DNA binding residues [nucleotide binding]
223283012429	dimerization interface [polypeptide binding]; other site
223283012430	Uncharacterized conserved protein [Function unknown]; Region: COG3148
223283012431	Domain of unknown function (DUF4146); Region: DUF4146; pfam13652
223283012432	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
223283012433	recombination regulator RecX; Reviewed; Region: recX; PRK00117
223283012434	recombinase A; Provisional; Region: recA; PRK09354
223283012435	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
223283012436	hexamer interface [polypeptide binding]; other site
223283012437	Walker A motif; other site
223283012438	ATP binding site [chemical binding]; other site
223283012439	Walker B motif; other site
223283012440	Competence-damaged protein; Region: CinA; pfam02464
223283012441	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
223283012442	PHAGE06; putative prophage; putative lysogenic prophage region.
223283012443	Predicted chitinase [General function prediction only]; Region: COG3179
223283012444	catalytic residue [active]
223283012445	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
223283012446	Putative phage tail protein; Region: Phage-tail_3; pfam13550
223283012447	Fibronectin type III domain; Region: fn3; pfam00041
223283012448	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
223283012449	tape measure domain; Region: tape_meas_nterm; TIGR02675
223283012450	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
223283012451	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
223283012452	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
223283012453	chaperone protein DnaJ; Provisional; Region: PRK14291
223283012454	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
223283012455	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
223283012456	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
223283012457	dimer interface [polypeptide binding]; other site
223283012458	active site
223283012459	Int/Topo IB signature motif; other site
223283012460	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
223283012461	MutS domain I; Region: MutS_I; pfam01624
223283012462	MutS domain II; Region: MutS_II; pfam05188
223283012463	MutS domain III; Region: MutS_III; pfam05192
223283012464	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
223283012465	Walker A/P-loop; other site
223283012466	ATP binding site [chemical binding]; other site
223283012467	Q-loop/lid; other site
223283012468	ABC transporter signature motif; other site
223283012469	Walker B; other site
223283012470	D-loop; other site
223283012471	H-loop/switch region; other site
223283012472	Ferredoxin [Energy production and conversion]; Region: COG1146
223283012473	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
223283012474	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283012475	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283012476	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283012477	cell density-dependent motility repressor; Provisional; Region: PRK10082
223283012478	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283012479	LysR substrate binding domain; Region: LysR_substrate; pfam03466
223283012480	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
223283012481	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
223283012482	putative active site pocket [active]
223283012483	metal binding site [ion binding]; metal-binding site
223283012484	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
223283012485	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
223283012486	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283012487	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283012488	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
223283012489	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
223283012490	putative NAD(P) binding site [chemical binding]; other site
223283012491	active site
223283012492	YCII-related domain; Region: YCII; cl00999
223283012493	short chain dehydrogenase; Provisional; Region: PRK06179
223283012494	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
223283012495	NADP binding site [chemical binding]; other site
223283012496	active site
223283012497	steroid binding site; other site
223283012498	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
223283012499	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
223283012500	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
223283012501	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
223283012502	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
223283012503	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
223283012504	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
223283012505	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
223283012506	Walker A/P-loop; other site
223283012507	ATP binding site [chemical binding]; other site
223283012508	Q-loop/lid; other site
223283012509	ABC transporter signature motif; other site
223283012510	Walker B; other site
223283012511	D-loop; other site
223283012512	H-loop/switch region; other site
223283012513	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
223283012514	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
223283012515	Walker A/P-loop; other site
223283012516	ATP binding site [chemical binding]; other site
223283012517	Q-loop/lid; other site
223283012518	ABC transporter signature motif; other site
223283012519	Walker B; other site
223283012520	D-loop; other site
223283012521	H-loop/switch region; other site
223283012522	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
223283012523	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
223283012524	TM-ABC transporter signature motif; other site
223283012525	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283012526	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
223283012527	TM-ABC transporter signature motif; other site
223283012528	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
223283012529	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
223283012530	putative ligand binding site [chemical binding]; other site
223283012531	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
223283012532	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283012533	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283012534	dimer interface [polypeptide binding]; other site
223283012535	phosphorylation site [posttranslational modification]
223283012536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283012537	ATP binding site [chemical binding]; other site
223283012538	Mg2+ binding site [ion binding]; other site
223283012539	G-X-G motif; other site
223283012540	Response regulator receiver domain; Region: Response_reg; pfam00072
223283012541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283012542	active site
223283012543	phosphorylation site [posttranslational modification]
223283012544	intermolecular recognition site; other site
223283012545	dimerization interface [polypeptide binding]; other site
223283012546	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283012547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283012548	active site
223283012549	phosphorylation site [posttranslational modification]
223283012550	intermolecular recognition site; other site
223283012551	dimerization interface [polypeptide binding]; other site
223283012552	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283012553	DNA binding residues [nucleotide binding]
223283012554	PAAR motif; Region: PAAR_motif; pfam05488
223283012555	RHS Repeat; Region: RHS_repeat; pfam05593
223283012556	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
223283012557	RHS Repeat; Region: RHS_repeat; cl11982
223283012558	RHS Repeat; Region: RHS_repeat; cl11982
223283012559	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
223283012560	classical (c) SDRs; Region: SDR_c; cd05233
223283012561	NAD(P) binding site [chemical binding]; other site
223283012562	active site
223283012563	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
223283012564	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
223283012565	Right handed beta helix region; Region: Beta_helix; pfam13229
223283012566	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
223283012567	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
223283012568	Cadherin repeat-like domain; Region: CA_like; cl15786
223283012569	Ca2+ binding site [ion binding]; other site
223283012570	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
223283012571	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
223283012572	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
223283012573	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
223283012574	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
223283012575	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
223283012576	substrate binding site [chemical binding]; other site
223283012577	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
223283012578	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
223283012579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283012580	Walker A/P-loop; other site
223283012581	ATP binding site [chemical binding]; other site
223283012582	Q-loop/lid; other site
223283012583	ABC transporter signature motif; other site
223283012584	Walker B; other site
223283012585	D-loop; other site
223283012586	H-loop/switch region; other site
223283012587	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
223283012588	Protein of unknown function, DUF482; Region: DUF482; pfam04339
223283012589	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
223283012590	Leucine rich repeat; Region: LRR_8; pfam13855
223283012591	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
223283012592	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
223283012593	dimer interface [polypeptide binding]; other site
223283012594	active site
223283012595	CoA binding pocket [chemical binding]; other site
223283012596	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
223283012597	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283012598	ATP binding site [chemical binding]; other site
223283012599	putative Mg++ binding site [ion binding]; other site
223283012600	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283012601	nucleotide binding region [chemical binding]; other site
223283012602	ATP-binding site [chemical binding]; other site
223283012603	Helicase associated domain (HA2); Region: HA2; pfam04408
223283012604	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
223283012605	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
223283012606	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
223283012607	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
223283012608	acyl-activating enzyme (AAE) consensus motif; other site
223283012609	putative AMP binding site [chemical binding]; other site
223283012610	putative active site [active]
223283012611	putative CoA binding site [chemical binding]; other site
223283012612	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
223283012613	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
223283012614	acyl-activating enzyme (AAE) consensus motif; other site
223283012615	putative AMP binding site [chemical binding]; other site
223283012616	putative active site [active]
223283012617	putative CoA binding site [chemical binding]; other site
223283012618	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
223283012619	dimer interaction site [polypeptide binding]; other site
223283012620	substrate-binding tunnel; other site
223283012621	active site
223283012622	catalytic site [active]
223283012623	substrate binding site [chemical binding]; other site
223283012624	Pectate lyase; Region: Pec_lyase_C; cl01593
223283012625	ATP-dependent helicase HepA; Validated; Region: PRK04914
223283012626	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283012627	ATP binding site [chemical binding]; other site
223283012628	putative Mg++ binding site [ion binding]; other site
223283012629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283012630	nucleotide binding region [chemical binding]; other site
223283012631	ATP-binding site [chemical binding]; other site
223283012632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283012633	putative substrate translocation pore; other site
223283012634	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283012635	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
223283012636	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
223283012637	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
223283012638	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283012639	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283012640	metal binding site [ion binding]; metal-binding site
223283012641	active site
223283012642	I-site; other site
223283012643	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283012644	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
223283012645	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
223283012646	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
223283012647	dimerization interface [polypeptide binding]; other site
223283012648	ligand binding site [chemical binding]; other site
223283012649	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283012650	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
223283012651	TM-ABC transporter signature motif; other site
223283012652	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
223283012653	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
223283012654	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
223283012655	TM-ABC transporter signature motif; other site
223283012656	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
223283012657	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
223283012658	Walker A/P-loop; other site
223283012659	ATP binding site [chemical binding]; other site
223283012660	Q-loop/lid; other site
223283012661	ABC transporter signature motif; other site
223283012662	Walker B; other site
223283012663	D-loop; other site
223283012664	H-loop/switch region; other site
223283012665	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
223283012666	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
223283012667	Walker A/P-loop; other site
223283012668	ATP binding site [chemical binding]; other site
223283012669	Q-loop/lid; other site
223283012670	ABC transporter signature motif; other site
223283012671	Walker B; other site
223283012672	D-loop; other site
223283012673	H-loop/switch region; other site
223283012674	Predicted membrane protein [Function unknown]; Region: COG3650
223283012675	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
223283012676	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283012677	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
223283012678	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
223283012679	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
223283012680	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
223283012681	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
223283012682	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
223283012683	ligand binding site [chemical binding]; other site
223283012684	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
223283012685	Beta-lactamase; Region: Beta-lactamase; pfam00144
223283012686	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
223283012687	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
223283012688	Predicted integral membrane protein [Function unknown]; Region: COG5615
223283012689	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
223283012690	Purine nucleoside permease (NUP); Region: NUP; pfam06516
223283012691	Protein of unknown function (DUF1145); Region: DUF1145; pfam06611
223283012692	hypothetical protein; Provisional; Region: PRK00183
223283012693	SEC-C motif; Region: SEC-C; pfam02810
223283012694	Secretin and TonB N terminus short domain; Region: STN; smart00965
223283012695	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283012696	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283012697	N-terminal plug; other site
223283012698	ligand-binding site [chemical binding]; other site
223283012699	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
223283012700	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
223283012701	Predicted transcriptional regulator [Transcription]; Region: COG2932
223283012702	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283012703	non-specific DNA binding site [nucleotide binding]; other site
223283012704	salt bridge; other site
223283012705	sequence-specific DNA binding site [nucleotide binding]; other site
223283012706	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
223283012707	Catalytic site [active]
223283012708	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
223283012709	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
223283012710	active site
223283012711	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
223283012712	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
223283012713	ATP-dependent DNA ligase; Validated; Region: PRK09247
223283012714	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
223283012715	active site
223283012716	DNA binding site [nucleotide binding]
223283012717	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
223283012718	DNA binding site [nucleotide binding]
223283012719	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
223283012720	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283012721	substrate binding pocket [chemical binding]; other site
223283012722	membrane-bound complex binding site; other site
223283012723	hinge residues; other site
223283012724	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283012725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283012726	dimer interface [polypeptide binding]; other site
223283012727	conserved gate region; other site
223283012728	putative PBP binding loops; other site
223283012729	ABC-ATPase subunit interface; other site
223283012730	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283012731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283012732	dimer interface [polypeptide binding]; other site
223283012733	conserved gate region; other site
223283012734	putative PBP binding loops; other site
223283012735	ABC-ATPase subunit interface; other site
223283012736	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
223283012737	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
223283012738	active site
223283012739	Zn binding site [ion binding]; other site
223283012740	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
223283012741	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283012742	Walker A/P-loop; other site
223283012743	ATP binding site [chemical binding]; other site
223283012744	Q-loop/lid; other site
223283012745	ABC transporter signature motif; other site
223283012746	Walker B; other site
223283012747	D-loop; other site
223283012748	H-loop/switch region; other site
223283012749	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
223283012750	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283012751	ATP binding site [chemical binding]; other site
223283012752	putative Mg++ binding site [ion binding]; other site
223283012753	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283012754	nucleotide binding region [chemical binding]; other site
223283012755	ATP-binding site [chemical binding]; other site
223283012756	DEAD/H associated; Region: DEAD_assoc; pfam08494
223283012757	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
223283012758	putative active site [active]
223283012759	putative metal binding site [ion binding]; other site
223283012760	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
223283012761	trimer interface [polypeptide binding]; other site
223283012762	active site
223283012763	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
223283012764	DNA-binding site [nucleotide binding]; DNA binding site
223283012765	RNA-binding motif; other site
223283012766	antiporter inner membrane protein; Provisional; Region: PRK11670
223283012767	Domain of unknown function DUF59; Region: DUF59; pfam01883
223283012768	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
223283012769	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
223283012770	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
223283012771	active site
223283012772	HIGH motif; other site
223283012773	KMSKS motif; other site
223283012774	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
223283012775	tRNA binding surface [nucleotide binding]; other site
223283012776	anticodon binding site; other site
223283012777	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
223283012778	dimer interface [polypeptide binding]; other site
223283012779	putative tRNA-binding site [nucleotide binding]; other site
223283012780	ferredoxin; Provisional; Region: PRK08764
223283012781	Putative Fe-S cluster; Region: FeS; cl17515
223283012782	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
223283012783	endonuclease III; Provisional; Region: PRK10702
223283012784	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
223283012785	minor groove reading motif; other site
223283012786	helix-hairpin-helix signature motif; other site
223283012787	substrate binding pocket [chemical binding]; other site
223283012788	active site
223283012789	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
223283012790	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283012791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283012792	active site
223283012793	phosphorylation site [posttranslational modification]
223283012794	intermolecular recognition site; other site
223283012795	dimerization interface [polypeptide binding]; other site
223283012796	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283012797	DNA binding residues [nucleotide binding]
223283012798	dimerization interface [polypeptide binding]; other site
223283012799	Transposase domain (DUF772); Region: DUF772; pfam05598
223283012800	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283012801	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283012802	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
223283012803	argininosuccinate synthase; Provisional; Region: PRK13820
223283012804	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
223283012805	ANP binding site [chemical binding]; other site
223283012806	Substrate Binding Site II [chemical binding]; other site
223283012807	Substrate Binding Site I [chemical binding]; other site
223283012808	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
223283012809	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
223283012810	ligand binding site [chemical binding]; other site
223283012811	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
223283012812	active site
223283012813	substrate binding pocket [chemical binding]; other site
223283012814	dimer interface [polypeptide binding]; other site
223283012815	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
223283012816	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
223283012817	dimer interface [polypeptide binding]; other site
223283012818	catalytic site [active]
223283012819	putative active site [active]
223283012820	putative substrate binding site [chemical binding]; other site
223283012821	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
223283012822	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
223283012823	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
223283012824	heme binding site [chemical binding]; other site
223283012825	ferroxidase pore; other site
223283012826	ferroxidase diiron center [ion binding]; other site
223283012827	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
223283012828	putative GSH binding site [chemical binding]; other site
223283012829	catalytic residues [active]
223283012830	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
223283012831	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
223283012832	putative [Fe4-S4] binding site [ion binding]; other site
223283012833	putative molybdopterin cofactor binding site [chemical binding]; other site
223283012834	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
223283012835	putative molybdopterin cofactor binding site; other site
223283012836	ornithine carbamoyltransferase; Provisional; Region: PRK00779
223283012837	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
223283012838	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
223283012839	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
223283012840	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
223283012841	Walker A/P-loop; other site
223283012842	ATP binding site [chemical binding]; other site
223283012843	Q-loop/lid; other site
223283012844	ABC transporter signature motif; other site
223283012845	Walker B; other site
223283012846	D-loop; other site
223283012847	H-loop/switch region; other site
223283012848	TOBE domain; Region: TOBE_2; pfam08402
223283012849	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
223283012850	putative deacylase active site [active]
223283012851	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
223283012852	amphipathic channel; other site
223283012853	Asn-Pro-Ala signature motifs; other site
223283012854	glycerol kinase; Provisional; Region: glpK; PRK00047
223283012855	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
223283012856	N- and C-terminal domain interface [polypeptide binding]; other site
223283012857	active site
223283012858	MgATP binding site [chemical binding]; other site
223283012859	catalytic site [active]
223283012860	metal binding site [ion binding]; metal-binding site
223283012861	glycerol binding site [chemical binding]; other site
223283012862	homotetramer interface [polypeptide binding]; other site
223283012863	homodimer interface [polypeptide binding]; other site
223283012864	protein IIAGlc interface [polypeptide binding]; other site
223283012865	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
223283012866	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
223283012867	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
223283012868	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
223283012869	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283012870	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283012871	substrate binding pocket [chemical binding]; other site
223283012872	membrane-bound complex binding site; other site
223283012873	hinge residues; other site
223283012874	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283012875	dimer interface [polypeptide binding]; other site
223283012876	conserved gate region; other site
223283012877	putative PBP binding loops; other site
223283012878	ABC-ATPase subunit interface; other site
223283012879	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283012880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283012881	dimer interface [polypeptide binding]; other site
223283012882	conserved gate region; other site
223283012883	putative PBP binding loops; other site
223283012884	ABC-ATPase subunit interface; other site
223283012885	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
223283012886	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283012887	Walker A/P-loop; other site
223283012888	ATP binding site [chemical binding]; other site
223283012889	Q-loop/lid; other site
223283012890	ABC transporter signature motif; other site
223283012891	Walker B; other site
223283012892	D-loop; other site
223283012893	H-loop/switch region; other site
223283012894	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
223283012895	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283012896	dimer interface [polypeptide binding]; other site
223283012897	phosphorylation site [posttranslational modification]
223283012898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283012899	ATP binding site [chemical binding]; other site
223283012900	Mg2+ binding site [ion binding]; other site
223283012901	G-X-G motif; other site
223283012902	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
223283012903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283012904	active site
223283012905	phosphorylation site [posttranslational modification]
223283012906	intermolecular recognition site; other site
223283012907	dimerization interface [polypeptide binding]; other site
223283012908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283012909	Walker A motif; other site
223283012910	ATP binding site [chemical binding]; other site
223283012911	Walker B motif; other site
223283012912	arginine finger; other site
223283012913	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283012914	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
223283012915	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
223283012916	catalytic residues [active]
223283012917	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
223283012918	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
223283012919	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
223283012920	THF binding site; other site
223283012921	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
223283012922	substrate binding site [chemical binding]; other site
223283012923	THF binding site; other site
223283012924	zinc-binding site [ion binding]; other site
223283012925	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
223283012926	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283012927	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
223283012928	putative dimerization interface [polypeptide binding]; other site
223283012929	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
223283012930	nudix motif; other site
223283012931	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
223283012932	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
223283012933	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
223283012934	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
223283012935	OpgC protein; Region: OpgC_C; pfam10129
223283012936	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
223283012937	Transglycosylase; Region: Transgly; pfam00912
223283012938	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
223283012939	Predicted transcriptional regulators [Transcription]; Region: COG1695
223283012940	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
223283012941	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
223283012942	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
223283012943	FAD binding pocket [chemical binding]; other site
223283012944	FAD binding motif [chemical binding]; other site
223283012945	phosphate binding motif [ion binding]; other site
223283012946	NAD binding pocket [chemical binding]; other site
223283012947	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
223283012948	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
223283012949	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
223283012950	Trp docking motif [polypeptide binding]; other site
223283012951	putative active site [active]
223283012952	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
223283012953	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
223283012954	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
223283012955	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
223283012956	classical (c) SDRs; Region: SDR_c; cd05233
223283012957	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
223283012958	NAD(P) binding site [chemical binding]; other site
223283012959	active site
223283012960	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
223283012961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283012962	NAD(P) binding site [chemical binding]; other site
223283012963	active site
223283012964	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283012965	benzoate transport; Region: 2A0115; TIGR00895
223283012966	putative substrate translocation pore; other site
223283012967	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283012968	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
223283012969	active site
223283012970	catalytic site [active]
223283012971	Zn binding site [ion binding]; other site
223283012972	tetramer interface [polypeptide binding]; other site
223283012973	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
223283012974	hypothetical protein; Provisional; Region: PRK06102
223283012975	Amidase; Region: Amidase; cl11426
223283012976	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283012977	DNA-binding site [nucleotide binding]; DNA binding site
223283012978	Transcriptional regulators [Transcription]; Region: GntR; COG1802
223283012979	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283012980	DNA-binding site [nucleotide binding]; DNA binding site
223283012981	FCD domain; Region: FCD; pfam07729
223283012982	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
223283012983	apolar tunnel; other site
223283012984	heme binding site [chemical binding]; other site
223283012985	dimerization interface [polypeptide binding]; other site
223283012986	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
223283012987	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283012988	dimerization interface [polypeptide binding]; other site
223283012989	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283012990	metal binding site [ion binding]; metal-binding site
223283012991	active site
223283012992	I-site; other site
223283012993	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283012994	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
223283012995	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
223283012996	Domain of unknown function(DUF2779); Region: DUF2779; pfam11074
223283012997	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283012998	Walker A motif; other site
223283012999	ATP binding site [chemical binding]; other site
223283013000	Walker B motif; other site
223283013001	arginine finger; other site
223283013002	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
223283013003	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
223283013004	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283013005	S-adenosylmethionine binding site [chemical binding]; other site
223283013006	Methyltransferase domain; Region: Methyltransf_31; pfam13847
223283013007	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283013008	S-adenosylmethionine binding site [chemical binding]; other site
223283013009	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
223283013010	active site
223283013011	hydrophilic channel; other site
223283013012	dimerization interface [polypeptide binding]; other site
223283013013	catalytic residues [active]
223283013014	active site lid [active]
223283013015	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
223283013016	Recombination protein O N terminal; Region: RecO_N; pfam11967
223283013017	Recombination protein O C terminal; Region: RecO_C; pfam02565
223283013018	GTPase Era; Reviewed; Region: era; PRK00089
223283013019	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
223283013020	G1 box; other site
223283013021	GTP/Mg2+ binding site [chemical binding]; other site
223283013022	Switch I region; other site
223283013023	G2 box; other site
223283013024	Switch II region; other site
223283013025	G3 box; other site
223283013026	G4 box; other site
223283013027	G5 box; other site
223283013028	ribonuclease III; Reviewed; Region: rnc; PRK00102
223283013029	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
223283013030	dimerization interface [polypeptide binding]; other site
223283013031	active site
223283013032	metal binding site [ion binding]; metal-binding site
223283013033	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
223283013034	dsRNA binding site [nucleotide binding]; other site
223283013035	signal peptidase I; Provisional; Region: PRK10861
223283013036	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
223283013037	Catalytic site [active]
223283013038	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
223283013039	GTP-binding protein LepA; Provisional; Region: PRK05433
223283013040	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
223283013041	G1 box; other site
223283013042	putative GEF interaction site [polypeptide binding]; other site
223283013043	GTP/Mg2+ binding site [chemical binding]; other site
223283013044	Switch I region; other site
223283013045	G2 box; other site
223283013046	G3 box; other site
223283013047	Switch II region; other site
223283013048	G4 box; other site
223283013049	G5 box; other site
223283013050	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
223283013051	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
223283013052	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
223283013053	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
223283013054	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
223283013055	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
223283013056	protein binding site [polypeptide binding]; other site
223283013057	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
223283013058	protein binding site [polypeptide binding]; other site
223283013059	MucB/RseB family; Region: MucB_RseB; pfam03888
223283013060	anti-sigma E factor; Provisional; Region: rseB; PRK09455
223283013061	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
223283013062	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
223283013063	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
223283013064	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
223283013065	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283013066	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283013067	DNA binding residues [nucleotide binding]
223283013068	L-aspartate oxidase; Provisional; Region: PRK09077
223283013069	L-aspartate oxidase; Provisional; Region: PRK06175
223283013070	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
223283013071	Uncharacterized conserved protein [Function unknown]; Region: COG2938
223283013072	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
223283013073	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
223283013074	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
223283013075	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
223283013076	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283013077	HAMP domain; Region: HAMP; pfam00672
223283013078	dimerization interface [polypeptide binding]; other site
223283013079	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283013080	dimer interface [polypeptide binding]; other site
223283013081	phosphorylation site [posttranslational modification]
223283013082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283013083	ATP binding site [chemical binding]; other site
223283013084	Mg2+ binding site [ion binding]; other site
223283013085	G-X-G motif; other site
223283013086	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
223283013087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283013088	active site
223283013089	phosphorylation site [posttranslational modification]
223283013090	intermolecular recognition site; other site
223283013091	dimerization interface [polypeptide binding]; other site
223283013092	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283013093	DNA binding site [nucleotide binding]
223283013094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
223283013095	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
223283013096	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
223283013097	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
223283013098	Putative ammonia monooxygenase; Region: AmoA; pfam05145
223283013099	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
223283013100	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
223283013101	ligand binding site [chemical binding]; other site
223283013102	active site
223283013103	UGI interface [polypeptide binding]; other site
223283013104	catalytic site [active]
223283013105	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
223283013106	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
223283013107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
223283013108	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
223283013109	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
223283013110	Walker A/P-loop; other site
223283013111	ATP binding site [chemical binding]; other site
223283013112	Q-loop/lid; other site
223283013113	ABC transporter signature motif; other site
223283013114	Walker B; other site
223283013115	D-loop; other site
223283013116	H-loop/switch region; other site
223283013117	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
223283013118	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
223283013119	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
223283013120	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
223283013121	urea carboxylase; Region: urea_carbox; TIGR02712
223283013122	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
223283013123	ATP-grasp domain; Region: ATP-grasp_4; cl17255
223283013124	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
223283013125	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
223283013126	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
223283013127	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
223283013128	carboxyltransferase (CT) interaction site; other site
223283013129	biotinylation site [posttranslational modification]; other site
223283013130	allophanate hydrolase; Provisional; Region: PRK08186
223283013131	Amidase; Region: Amidase; cl11426
223283013132	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
223283013133	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
223283013134	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
223283013135	RNA binding surface [nucleotide binding]; other site
223283013136	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
223283013137	active site
223283013138	uracil binding [chemical binding]; other site
223283013139	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
223283013140	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283013141	non-specific DNA binding site [nucleotide binding]; other site
223283013142	salt bridge; other site
223283013143	sequence-specific DNA binding site [nucleotide binding]; other site
223283013144	Domain of unknown function (DUF955); Region: DUF955; pfam06114
223283013145	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283013146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283013147	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283013148	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283013149	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283013150	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283013151	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283013152	Transposase domain (DUF772); Region: DUF772; pfam05598
223283013153	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283013154	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283013155	glutathione reductase; Validated; Region: PRK06116
223283013156	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283013157	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283013158	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
223283013159	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
223283013160	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
223283013161	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
223283013162	FMN binding site [chemical binding]; other site
223283013163	active site
223283013164	substrate binding site [chemical binding]; other site
223283013165	catalytic residue [active]
223283013166	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
223283013167	active site 1 [active]
223283013168	dimer interface [polypeptide binding]; other site
223283013169	hexamer interface [polypeptide binding]; other site
223283013170	active site 2 [active]
223283013171	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
223283013172	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
223283013173	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
223283013174	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
223283013175	TrkA-N domain; Region: TrkA_N; pfam02254
223283013176	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
223283013177	catalytic residues [active]
223283013178	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
223283013179	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
223283013180	catalytic residues [active]
223283013181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283013182	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283013183	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
223283013184	classical (c) SDRs; Region: SDR_c; cd05233
223283013185	NAD(P) binding site [chemical binding]; other site
223283013186	active site
223283013187	OsmC-like protein; Region: OsmC; pfam02566
223283013188	cystathionine beta-lyase; Provisional; Region: PRK05967
223283013189	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
223283013190	homodimer interface [polypeptide binding]; other site
223283013191	substrate-cofactor binding pocket; other site
223283013192	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283013193	catalytic residue [active]
223283013194	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
223283013195	EamA-like transporter family; Region: EamA; pfam00892
223283013196	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283013197	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283013198	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283013199	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283013200	DNA-binding interface [nucleotide binding]; DNA binding site
223283013201	Integrase core domain; Region: rve; pfam00665
223283013202	Integrase core domain; Region: rve_3; cl15866
223283013203	transposase/IS protein; Provisional; Region: PRK09183
223283013204	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283013205	Walker A motif; other site
223283013206	ATP binding site [chemical binding]; other site
223283013207	Walker B motif; other site
223283013208	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
223283013209	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283013210	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283013211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283013212	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
223283013213	NAD(P) binding site [chemical binding]; other site
223283013214	active site
223283013215	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283013216	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283013217	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
223283013218	putative effector binding pocket; other site
223283013219	dimerization interface [polypeptide binding]; other site
223283013220	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
223283013221	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
223283013222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283013223	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283013224	putative substrate translocation pore; other site
223283013225	Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154
223283013226	putative homodimer interface [polypeptide binding]; other site
223283013227	putative homotetramer interface [polypeptide binding]; other site
223283013228	putative metal binding site [ion binding]; other site
223283013229	putative homodimer-homodimer interface [polypeptide binding]; other site
223283013230	putative allosteric switch controlling residues; other site
223283013231	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
223283013232	Predicted membrane protein [Function unknown]; Region: COG1238
223283013233	Pectate lyase; Region: Pec_lyase_C; cl01593
223283013234	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
223283013235	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
223283013236	putative alcohol dehydrogenase; Provisional; Region: PRK09860
223283013237	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
223283013238	dimer interface [polypeptide binding]; other site
223283013239	active site
223283013240	metal binding site [ion binding]; metal-binding site
223283013241	Methyltransferase domain; Region: Methyltransf_31; pfam13847
223283013242	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283013243	S-adenosylmethionine binding site [chemical binding]; other site
223283013244	Repair protein; Region: Repair_PSII; cl01535
223283013245	Repair protein; Region: Repair_PSII; pfam04536
223283013246	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
223283013247	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
223283013248	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
223283013249	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
223283013250	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283013251	dimer interface [polypeptide binding]; other site
223283013252	phosphorylation site [posttranslational modification]
223283013253	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283013254	ATP binding site [chemical binding]; other site
223283013255	Mg2+ binding site [ion binding]; other site
223283013256	G-X-G motif; other site
223283013257	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
223283013258	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283013259	active site
223283013260	phosphorylation site [posttranslational modification]
223283013261	intermolecular recognition site; other site
223283013262	dimerization interface [polypeptide binding]; other site
223283013263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283013264	Walker A motif; other site
223283013265	ATP binding site [chemical binding]; other site
223283013266	Walker B motif; other site
223283013267	arginine finger; other site
223283013268	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
223283013269	PAS domain; Region: PAS_9; pfam13426
223283013270	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
223283013271	putative active site [active]
223283013272	heme pocket [chemical binding]; other site
223283013273	PAS fold; Region: PAS_4; pfam08448
223283013274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283013275	putative active site [active]
223283013276	heme pocket [chemical binding]; other site
223283013277	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283013278	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
223283013279	putative active site [active]
223283013280	heme pocket [chemical binding]; other site
223283013281	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283013282	dimer interface [polypeptide binding]; other site
223283013283	phosphorylation site [posttranslational modification]
223283013284	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283013285	ATP binding site [chemical binding]; other site
223283013286	Mg2+ binding site [ion binding]; other site
223283013287	G-X-G motif; other site
223283013288	Response regulator receiver domain; Region: Response_reg; pfam00072
223283013289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283013290	active site
223283013291	phosphorylation site [posttranslational modification]
223283013292	intermolecular recognition site; other site
223283013293	dimerization interface [polypeptide binding]; other site
223283013294	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
223283013295	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
223283013296	nucleotide binding site [chemical binding]; other site
223283013297	putative NEF/HSP70 interaction site [polypeptide binding]; other site
223283013298	SBD interface [polypeptide binding]; other site
223283013299	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
223283013300	HSP70 interaction site [polypeptide binding]; other site
223283013301	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
223283013302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283013303	putative substrate translocation pore; other site
223283013304	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
223283013305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283013306	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283013307	putative substrate translocation pore; other site
223283013308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283013309	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
223283013310	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
223283013311	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283013312	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
223283013313	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
223283013314	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283013315	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283013316	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
223283013317	Protein export membrane protein; Region: SecD_SecF; cl14618
223283013318	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
223283013319	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
223283013320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283013321	putative substrate translocation pore; other site
223283013322	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
223283013323	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
223283013324	dimer interface [polypeptide binding]; other site
223283013325	active site
223283013326	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
223283013327	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
223283013328	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
223283013329	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
223283013330	Bacterial transcriptional regulator; Region: IclR; pfam01614
223283013331	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
223283013332	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
223283013333	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
223283013334	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
223283013335	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
223283013336	putative active site [active]
223283013337	putative substrate binding site [chemical binding]; other site
223283013338	putative cosubstrate binding site; other site
223283013339	catalytic site [active]
223283013340	exonuclease I; Provisional; Region: sbcB; PRK11779
223283013341	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
223283013342	active site
223283013343	catalytic site [active]
223283013344	substrate binding site [chemical binding]; other site
223283013345	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
223283013346	Predicted membrane protein/domain [Function unknown]; Region: COG1714
223283013347	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
223283013348	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
223283013349	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283013350	active site
223283013351	catalytic residues [active]
223283013352	DNA binding site [nucleotide binding]
223283013353	Int/Topo IB signature motif; other site
223283013354	transcriptional regulator BetI; Validated; Region: PRK00767
223283013355	SIR2-like domain; Region: SIR2_2; pfam13289
223283013356	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283013357	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
223283013358	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
223283013359	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283013360	Transposase; Region: HTH_Tnp_1; pfam01527
223283013361	Domain of unknown function DUF87; Region: DUF87; pfam01935
223283013362	HerA helicase [Replication, recombination, and repair]; Region: COG0433
223283013363	Zonular occludens toxin (Zot); Region: Zot; cl17485
223283013364	MoxR-like ATPases [General function prediction only]; Region: COG0714
223283013365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283013366	Walker A motif; other site
223283013367	ATP binding site [chemical binding]; other site
223283013368	Walker B motif; other site
223283013369	arginine finger; other site
223283013370	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
223283013371	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
223283013372	metal ion-dependent adhesion site (MIDAS); other site
223283013373	PilZ domain; Region: PilZ; pfam07238
223283013374	pyruvate kinase; Provisional; Region: PRK05826
223283013375	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
223283013376	domain interfaces; other site
223283013377	active site
223283013378	hypothetical protein; Provisional; Region: PRK05713
223283013379	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
223283013380	catalytic loop [active]
223283013381	iron binding site [ion binding]; other site
223283013382	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
223283013383	FAD binding pocket [chemical binding]; other site
223283013384	FAD binding motif [chemical binding]; other site
223283013385	phosphate binding motif [ion binding]; other site
223283013386	beta-alpha-beta structure motif; other site
223283013387	NAD binding pocket [chemical binding]; other site
223283013388	putative fumarate hydratase; Provisional; Region: PRK15392
223283013389	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
223283013390	Fumarase C-terminus; Region: Fumerase_C; pfam05683
223283013391	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
223283013392	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
223283013393	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
223283013394	Family description; Region: VCBS; pfam13517
223283013395	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
223283013396	Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255
223283013397	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
223283013398	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
223283013399	Protein of unknown function (DUF796); Region: DUF796; cl01226
223283013400	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
223283013401	Transposase domain (DUF772); Region: DUF772; pfam05598
223283013402	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283013403	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283013404	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
223283013405	PLD-like domain; Region: PLDc_2; pfam13091
223283013406	putative active site [active]
223283013407	catalytic site [active]
223283013408	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
223283013409	PLD-like domain; Region: PLDc_2; pfam13091
223283013410	putative active site [active]
223283013411	catalytic site [active]
223283013412	YceI-like domain; Region: YceI; pfam04264
223283013413	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
223283013414	Beta-lactamase; Region: Beta-lactamase; pfam00144
223283013415	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
223283013416	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
223283013417	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
223283013418	putative acyl-acceptor binding pocket; other site
223283013419	Protein of unknown function, DUF479; Region: DUF479; cl01203
223283013420	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283013421	dimerization interface [polypeptide binding]; other site
223283013422	putative DNA binding site [nucleotide binding]; other site
223283013423	putative Zn2+ binding site [ion binding]; other site
223283013424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283013425	putative substrate translocation pore; other site
223283013426	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283013427	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
223283013428	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
223283013429	FMN binding site [chemical binding]; other site
223283013430	active site
223283013431	substrate binding site [chemical binding]; other site
223283013432	catalytic residue [active]
223283013433	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
223283013434	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
223283013435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283013436	NAD(P) binding site [chemical binding]; other site
223283013437	active site
223283013438	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
223283013439	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283013440	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283013441	dimerization interface [polypeptide binding]; other site
223283013442	Lysine efflux permease [General function prediction only]; Region: COG1279
223283013443	superoxide dismutase; Provisional; Region: PRK10543
223283013444	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
223283013445	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
223283013446	biofilm formation regulator HmsP; Provisional; Region: PRK11829
223283013447	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283013448	metal binding site [ion binding]; metal-binding site
223283013449	active site
223283013450	I-site; other site
223283013451	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283013452	Imelysin; Region: Peptidase_M75; cl09159
223283013453	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
223283013454	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
223283013455	Imelysin; Region: Peptidase_M75; cl09159
223283013456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
223283013457	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
223283013458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283013459	S-adenosylmethionine binding site [chemical binding]; other site
223283013460	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283013461	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283013462	dimer interface [polypeptide binding]; other site
223283013463	phosphorylation site [posttranslational modification]
223283013464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283013465	ATP binding site [chemical binding]; other site
223283013466	Mg2+ binding site [ion binding]; other site
223283013467	G-X-G motif; other site
223283013468	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
223283013469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283013470	active site
223283013471	phosphorylation site [posttranslational modification]
223283013472	intermolecular recognition site; other site
223283013473	dimerization interface [polypeptide binding]; other site
223283013474	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283013475	DNA binding site [nucleotide binding]
223283013476	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
223283013477	active site
223283013478	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
223283013479	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
223283013480	ring oligomerisation interface [polypeptide binding]; other site
223283013481	ATP/Mg binding site [chemical binding]; other site
223283013482	stacking interactions; other site
223283013483	hinge regions; other site
223283013484	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
223283013485	oligomerisation interface [polypeptide binding]; other site
223283013486	mobile loop; other site
223283013487	roof hairpin; other site
223283013488	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
223283013489	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
223283013490	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283013491	NAD(P) binding site [chemical binding]; other site
223283013492	active site
223283013493	Protein of unknown function, DUF481; Region: DUF481; pfam04338
223283013494	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
223283013495	DNA binding site [nucleotide binding]
223283013496	active site
223283013497	muropeptide transporter; Validated; Region: ampG; cl17669
223283013498	muropeptide transporter; Validated; Region: ampG; cl17669
223283013499	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
223283013500	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
223283013501	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
223283013502	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283013503	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283013504	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283013505	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283013506	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283013507	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283013508	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283013509	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
223283013510	Mechanosensitive ion channel; Region: MS_channel; pfam00924
223283013511	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
223283013512	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
223283013513	2-dehydropantoate 2-reductase; Provisional; Region: PRK05708
223283013514	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
223283013515	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
223283013516	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283013517	dimerization interface [polypeptide binding]; other site
223283013518	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
223283013519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283013520	putative active site [active]
223283013521	heme pocket [chemical binding]; other site
223283013522	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283013523	dimer interface [polypeptide binding]; other site
223283013524	phosphorylation site [posttranslational modification]
223283013525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283013526	ATP binding site [chemical binding]; other site
223283013527	Mg2+ binding site [ion binding]; other site
223283013528	G-X-G motif; other site
223283013529	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
223283013530	hypothetical protein; Provisional; Region: PRK08999
223283013531	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
223283013532	active site
223283013533	8-oxo-dGMP binding site [chemical binding]; other site
223283013534	nudix motif; other site
223283013535	metal binding site [ion binding]; metal-binding site
223283013536	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
223283013537	thiamine phosphate binding site [chemical binding]; other site
223283013538	active site
223283013539	pyrophosphate binding site [ion binding]; other site
223283013540	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
223283013541	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
223283013542	putative C-terminal domain interface [polypeptide binding]; other site
223283013543	putative GSH binding site (G-site) [chemical binding]; other site
223283013544	putative dimer interface [polypeptide binding]; other site
223283013545	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
223283013546	putative substrate binding pocket (H-site) [chemical binding]; other site
223283013547	putative N-terminal domain interface [polypeptide binding]; other site
223283013548	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
223283013549	heterotetramer interface [polypeptide binding]; other site
223283013550	active site pocket [active]
223283013551	cleavage site
223283013552	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103
223283013553	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
223283013554	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
223283013555	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
223283013556	nucleotide binding region [chemical binding]; other site
223283013557	ATP-binding site [chemical binding]; other site
223283013558	SEC-C motif; Region: SEC-C; pfam02810
223283013559	Protein of unknown function (DUF721); Region: DUF721; pfam05258
223283013560	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
223283013561	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
223283013562	cell division protein FtsZ; Validated; Region: PRK09330
223283013563	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
223283013564	nucleotide binding site [chemical binding]; other site
223283013565	SulA interaction site; other site
223283013566	cell division protein FtsA; Region: ftsA; TIGR01174
223283013567	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
223283013568	nucleotide binding site [chemical binding]; other site
223283013569	Cell division protein FtsA; Region: FtsA; pfam14450
223283013570	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
223283013571	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
223283013572	Cell division protein FtsQ; Region: FtsQ; pfam03799
223283013573	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
223283013574	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
223283013575	ATP-grasp domain; Region: ATP-grasp_4; cl17255
223283013576	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
223283013577	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
223283013578	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
223283013579	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
223283013580	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
223283013581	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
223283013582	active site
223283013583	homodimer interface [polypeptide binding]; other site
223283013584	cell division protein FtsW; Region: ftsW; TIGR02614
223283013585	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
223283013586	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
223283013587	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
223283013588	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
223283013589	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
223283013590	Mg++ binding site [ion binding]; other site
223283013591	putative catalytic motif [active]
223283013592	putative substrate binding site [chemical binding]; other site
223283013593	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
223283013594	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
223283013595	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
223283013596	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
223283013597	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
223283013598	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
223283013599	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
223283013600	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
223283013601	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
223283013602	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
223283013603	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
223283013604	Cell division protein FtsL; Region: FtsL; pfam04999
223283013605	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
223283013606	MraW methylase family; Region: Methyltransf_5; cl17771
223283013607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
223283013608	MraZ protein; Region: MraZ; pfam02381
223283013609	MraZ protein; Region: MraZ; pfam02381
223283013610	Predicted methyltransferases [General function prediction only]; Region: COG0313
223283013611	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
223283013612	putative SAM binding site [chemical binding]; other site
223283013613	putative homodimer interface [polypeptide binding]; other site
223283013614	LppC putative lipoprotein; Region: LppC; pfam04348
223283013615	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
223283013616	putative ligand binding site [chemical binding]; other site
223283013617	hypothetical protein; Reviewed; Region: PRK12497
223283013618	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
223283013619	dimer interface [polypeptide binding]; other site
223283013620	active site
223283013621	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
223283013622	BON domain; Region: BON; pfam04972
223283013623	BON domain; Region: BON; pfam04972
223283013624	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
223283013625	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
223283013626	stringent starvation protein A; Provisional; Region: sspA; PRK09481
223283013627	C-terminal domain interface [polypeptide binding]; other site
223283013628	putative GSH binding site (G-site) [chemical binding]; other site
223283013629	dimer interface [polypeptide binding]; other site
223283013630	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
223283013631	dimer interface [polypeptide binding]; other site
223283013632	N-terminal domain interface [polypeptide binding]; other site
223283013633	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
223283013634	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
223283013635	23S rRNA interface [nucleotide binding]; other site
223283013636	L3 interface [polypeptide binding]; other site
223283013637	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
223283013638	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
223283013639	conserved cys residue [active]
223283013640	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283013641	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283013642	Predicted ATPase [General function prediction only]; Region: COG1485
223283013643	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
223283013644	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
223283013645	active site
223283013646	HIGH motif; other site
223283013647	dimer interface [polypeptide binding]; other site
223283013648	KMSKS motif; other site
223283013649	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
223283013650	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
223283013651	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
223283013652	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
223283013653	CysD dimerization site [polypeptide binding]; other site
223283013654	G1 box; other site
223283013655	putative GEF interaction site [polypeptide binding]; other site
223283013656	GTP/Mg2+ binding site [chemical binding]; other site
223283013657	Switch I region; other site
223283013658	G2 box; other site
223283013659	G3 box; other site
223283013660	Switch II region; other site
223283013661	G4 box; other site
223283013662	G5 box; other site
223283013663	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
223283013664	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
223283013665	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
223283013666	ligand-binding site [chemical binding]; other site
223283013667	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
223283013668	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
223283013669	Active Sites [active]
223283013670	Uncharacterized conserved protein [Function unknown]; Region: COG0327
223283013671	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
223283013672	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
223283013673	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
223283013674	protein binding site [polypeptide binding]; other site
223283013675	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
223283013676	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
223283013677	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283013678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283013679	homodimer interface [polypeptide binding]; other site
223283013680	catalytic residue [active]
223283013681	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
223283013682	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
223283013683	NAD binding site [chemical binding]; other site
223283013684	dimerization interface [polypeptide binding]; other site
223283013685	product binding site; other site
223283013686	substrate binding site [chemical binding]; other site
223283013687	zinc binding site [ion binding]; other site
223283013688	catalytic residues [active]
223283013689	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
223283013690	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
223283013691	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
223283013692	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
223283013693	hinge; other site
223283013694	active site
223283013695	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
223283013696	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
223283013697	anti sigma factor interaction site; other site
223283013698	regulatory phosphorylation site [posttranslational modification]; other site
223283013699	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
223283013700	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
223283013701	mce related protein; Region: MCE; pfam02470
223283013702	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
223283013703	Permease; Region: Permease; cl00510
223283013704	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
223283013705	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
223283013706	Walker A/P-loop; other site
223283013707	ATP binding site [chemical binding]; other site
223283013708	Q-loop/lid; other site
223283013709	ABC transporter signature motif; other site
223283013710	Walker B; other site
223283013711	D-loop; other site
223283013712	H-loop/switch region; other site
223283013713	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
223283013714	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
223283013715	putative active site [active]
223283013716	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
223283013717	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
223283013718	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283013719	active site
223283013720	motif I; other site
223283013721	motif II; other site
223283013722	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
223283013723	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
223283013724	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
223283013725	OstA-like protein; Region: OstA; pfam03968
223283013726	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
223283013727	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
223283013728	Walker A/P-loop; other site
223283013729	ATP binding site [chemical binding]; other site
223283013730	Q-loop/lid; other site
223283013731	ABC transporter signature motif; other site
223283013732	Walker B; other site
223283013733	D-loop; other site
223283013734	H-loop/switch region; other site
223283013735	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
223283013736	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
223283013737	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
223283013738	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
223283013739	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
223283013740	30S subunit binding site; other site
223283013741	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
223283013742	active site
223283013743	phosphorylation site [posttranslational modification]
223283013744	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
223283013745	AAA domain; Region: AAA_18; pfam13238
223283013746	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
223283013747	dimerization domain swap beta strand [polypeptide binding]; other site
223283013748	regulatory protein interface [polypeptide binding]; other site
223283013749	active site
223283013750	regulatory phosphorylation site [posttranslational modification]; other site
223283013751	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
223283013752	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
223283013753	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
223283013754	Ebola nucleoprotein; Region: Ebola_NP; pfam05505
223283013755	fumarate hydratase; Reviewed; Region: fumC; PRK00485
223283013756	Class II fumarases; Region: Fumarase_classII; cd01362
223283013757	active site
223283013758	tetramer interface [polypeptide binding]; other site
223283013759	peptidase PmbA; Provisional; Region: PRK11040
223283013760	hypothetical protein; Provisional; Region: PRK05255
223283013761	protease TldD; Provisional; Region: tldD; PRK10735
223283013762	nitrilase; Region: PLN02798
223283013763	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
223283013764	putative active site [active]
223283013765	catalytic triad [active]
223283013766	dimer interface [polypeptide binding]; other site
223283013767	TIGR02099 family protein; Region: TIGR02099
223283013768	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
223283013769	ribonuclease G; Provisional; Region: PRK11712
223283013770	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
223283013771	homodimer interface [polypeptide binding]; other site
223283013772	oligonucleotide binding site [chemical binding]; other site
223283013773	Maf-like protein; Region: Maf; pfam02545
223283013774	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
223283013775	active site
223283013776	dimer interface [polypeptide binding]; other site
223283013777	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
223283013778	rod shape-determining protein MreC; Provisional; Region: PRK13922
223283013779	rod shape-determining protein MreC; Region: MreC; pfam04085
223283013780	rod shape-determining protein MreB; Provisional; Region: PRK13927
223283013781	MreB and similar proteins; Region: MreB_like; cd10225
223283013782	nucleotide binding site [chemical binding]; other site
223283013783	Mg binding site [ion binding]; other site
223283013784	putative protofilament interaction site [polypeptide binding]; other site
223283013785	RodZ interaction site [polypeptide binding]; other site
223283013786	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
223283013787	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
223283013788	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
223283013789	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
223283013790	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
223283013791	GatB domain; Region: GatB_Yqey; smart00845
223283013792	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
223283013793	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
223283013794	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
223283013795	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
223283013796	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
223283013797	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
223283013798	Predicted permeases [General function prediction only]; Region: COG0679
223283013799	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
223283013800	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
223283013801	putative active site [active]
223283013802	putative metal binding site [ion binding]; other site
223283013803	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
223283013804	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
223283013805	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
223283013806	putative RNA binding site [nucleotide binding]; other site
223283013807	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
223283013808	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
223283013809	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
223283013810	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
223283013811	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
223283013812	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283013813	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283013814	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283013815	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
223283013816	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
223283013817	RNase E interface [polypeptide binding]; other site
223283013818	trimer interface [polypeptide binding]; other site
223283013819	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
223283013820	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
223283013821	RNase E interface [polypeptide binding]; other site
223283013822	trimer interface [polypeptide binding]; other site
223283013823	active site
223283013824	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
223283013825	putative nucleic acid binding region [nucleotide binding]; other site
223283013826	G-X-X-G motif; other site
223283013827	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
223283013828	RNA binding site [nucleotide binding]; other site
223283013829	domain interface; other site
223283013830	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
223283013831	16S/18S rRNA binding site [nucleotide binding]; other site
223283013832	S13e-L30e interaction site [polypeptide binding]; other site
223283013833	25S rRNA binding site [nucleotide binding]; other site
223283013834	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
223283013835	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
223283013836	RNA binding site [nucleotide binding]; other site
223283013837	active site
223283013838	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
223283013839	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
223283013840	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
223283013841	translation initiation factor IF-2; Region: IF-2; TIGR00487
223283013842	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
223283013843	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
223283013844	G1 box; other site
223283013845	putative GEF interaction site [polypeptide binding]; other site
223283013846	GTP/Mg2+ binding site [chemical binding]; other site
223283013847	Switch I region; other site
223283013848	G2 box; other site
223283013849	G3 box; other site
223283013850	Switch II region; other site
223283013851	G4 box; other site
223283013852	G5 box; other site
223283013853	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
223283013854	Translation-initiation factor 2; Region: IF-2; pfam11987
223283013855	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
223283013856	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
223283013857	NusA N-terminal domain; Region: NusA_N; pfam08529
223283013858	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
223283013859	RNA binding site [nucleotide binding]; other site
223283013860	homodimer interface [polypeptide binding]; other site
223283013861	NusA-like KH domain; Region: KH_5; pfam13184
223283013862	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
223283013863	G-X-X-G motif; other site
223283013864	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
223283013865	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
223283013866	ribosome maturation protein RimP; Reviewed; Region: PRK00092
223283013867	Sm and related proteins; Region: Sm_like; cl00259
223283013868	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
223283013869	putative oligomer interface [polypeptide binding]; other site
223283013870	putative RNA binding site [nucleotide binding]; other site
223283013871	Preprotein translocase SecG subunit; Region: SecG; pfam03840
223283013872	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
223283013873	triosephosphate isomerase; Provisional; Region: PRK14567
223283013874	substrate binding site [chemical binding]; other site
223283013875	dimer interface [polypeptide binding]; other site
223283013876	catalytic triad [active]
223283013877	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
223283013878	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
223283013879	active site
223283013880	substrate binding site [chemical binding]; other site
223283013881	metal binding site [ion binding]; metal-binding site
223283013882	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
223283013883	dihydropteroate synthase; Region: DHPS; TIGR01496
223283013884	substrate binding pocket [chemical binding]; other site
223283013885	dimer interface [polypeptide binding]; other site
223283013886	inhibitor binding site; inhibition site
223283013887	FtsH Extracellular; Region: FtsH_ext; pfam06480
223283013888	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
223283013889	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283013890	Walker A motif; other site
223283013891	ATP binding site [chemical binding]; other site
223283013892	Walker B motif; other site
223283013893	arginine finger; other site
223283013894	Peptidase family M41; Region: Peptidase_M41; pfam01434
223283013895	FtsJ-like methyltransferase; Region: FtsJ; cl17430
223283013896	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
223283013897	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
223283013898	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
223283013899	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
223283013900	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
223283013901	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
223283013902	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
223283013903	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
223283013904	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
223283013905	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
223283013906	ATP-grasp domain; Region: ATP-grasp_4; cl17255
223283013907	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
223283013908	IMP binding site; other site
223283013909	dimer interface [polypeptide binding]; other site
223283013910	interdomain contacts; other site
223283013911	partial ornithine binding site; other site
223283013912	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
223283013913	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
223283013914	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
223283013915	catalytic site [active]
223283013916	subunit interface [polypeptide binding]; other site
223283013917	dihydrodipicolinate reductase; Provisional; Region: PRK00048
223283013918	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
223283013919	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
223283013920	chaperone protein DnaJ; Provisional; Region: PRK10767
223283013921	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
223283013922	HSP70 interaction site [polypeptide binding]; other site
223283013923	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
223283013924	substrate binding site [polypeptide binding]; other site
223283013925	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
223283013926	Zn binding sites [ion binding]; other site
223283013927	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
223283013928	dimer interface [polypeptide binding]; other site
223283013929	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
223283013930	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
223283013931	nucleotide binding site [chemical binding]; other site
223283013932	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
223283013933	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
223283013934	dimer interface [polypeptide binding]; other site
223283013935	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
223283013936	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
223283013937	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
223283013938	Walker A/P-loop; other site
223283013939	ATP binding site [chemical binding]; other site
223283013940	Q-loop/lid; other site
223283013941	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
223283013942	Q-loop/lid; other site
223283013943	ABC transporter signature motif; other site
223283013944	Walker B; other site
223283013945	D-loop; other site
223283013946	H-loop/switch region; other site
223283013947	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
223283013948	metal binding site 2 [ion binding]; metal-binding site
223283013949	putative DNA binding helix; other site
223283013950	metal binding site 1 [ion binding]; metal-binding site
223283013951	dimer interface [polypeptide binding]; other site
223283013952	structural Zn2+ binding site [ion binding]; other site
223283013953	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
223283013954	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
223283013955	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
223283013956	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283013957	putative transposase OrfB; Reviewed; Region: PHA02517
223283013958	Integrase core domain; Region: rve; pfam00665
223283013959	Integrase core domain; Region: rve_3; pfam13683
223283013960	RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658
223283013961	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
223283013962	putative coenzyme Q binding site [chemical binding]; other site
223283013963	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
223283013964	Na2 binding site [ion binding]; other site
223283013965	putative substrate binding site 1 [chemical binding]; other site
223283013966	Na binding site 1 [ion binding]; other site
223283013967	putative substrate binding site 2 [chemical binding]; other site
223283013968	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
223283013969	SmpB-tmRNA interface; other site
223283013970	K+-transporting ATPase, c chain; Region: KdpC; cl00944
223283013971	Fatty acid desaturase; Region: FA_desaturase; pfam00487
223283013972	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
223283013973	acyl-CoA synthetase; Validated; Region: PRK05850
223283013974	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
223283013975	acyl-activating enzyme (AAE) consensus motif; other site
223283013976	active site
223283013977	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283013978	Condensation domain; Region: Condensation; pfam00668
223283013979	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283013980	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283013981	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283013982	acyl-activating enzyme (AAE) consensus motif; other site
223283013983	AMP binding site [chemical binding]; other site
223283013984	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283013985	Condensation domain; Region: Condensation; pfam00668
223283013986	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283013987	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283013988	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
223283013989	acyl-activating enzyme (AAE) consensus motif; other site
223283013990	AMP binding site [chemical binding]; other site
223283013991	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283013992	Condensation domain; Region: Condensation; pfam00668
223283013993	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283013994	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283013995	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283013996	acyl-activating enzyme (AAE) consensus motif; other site
223283013997	AMP binding site [chemical binding]; other site
223283013998	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283013999	Condensation domain; Region: Condensation; pfam00668
223283014000	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283014001	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283014002	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283014003	acyl-activating enzyme (AAE) consensus motif; other site
223283014004	AMP binding site [chemical binding]; other site
223283014005	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283014006	Thioesterase domain; Region: Thioesterase; pfam00975
223283014007	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
223283014008	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
223283014009	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283014010	binding surface
223283014011	TPR motif; other site
223283014012	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
223283014013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283014014	S-adenosylmethionine binding site [chemical binding]; other site
223283014015	MbtH-like protein; Region: MbtH; cl01279
223283014016	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283014017	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283014018	putative substrate translocation pore; other site
223283014019	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
223283014020	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
223283014021	putative DNA binding site [nucleotide binding]; other site
223283014022	putative Zn2+ binding site [ion binding]; other site
223283014023	AsnC family; Region: AsnC_trans_reg; pfam01037
223283014024	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
223283014025	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
223283014026	tetramer interface [polypeptide binding]; other site
223283014027	active site
223283014028	Mg2+/Mn2+ binding site [ion binding]; other site
223283014029	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
223283014030	Amidase; Region: Amidase; pfam01425
223283014031	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
223283014032	Helix-turn-helix domain; Region: HTH_18; pfam12833
223283014033	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283014034	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
223283014035	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
223283014036	dimer interface [polypeptide binding]; other site
223283014037	active site
223283014038	heme binding site [chemical binding]; other site
223283014039	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
223283014040	PAS fold; Region: PAS_3; pfam08447
223283014041	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
223283014042	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283014043	PAS fold; Region: PAS_3; pfam08447
223283014044	putative active site [active]
223283014045	heme pocket [chemical binding]; other site
223283014046	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283014047	putative CheW interface [polypeptide binding]; other site
223283014048	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
223283014049	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
223283014050	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
223283014051	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
223283014052	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283014053	Walker A/P-loop; other site
223283014054	ATP binding site [chemical binding]; other site
223283014055	Q-loop/lid; other site
223283014056	ABC transporter signature motif; other site
223283014057	Walker B; other site
223283014058	D-loop; other site
223283014059	H-loop/switch region; other site
223283014060	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
223283014061	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
223283014062	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283014063	Walker A/P-loop; other site
223283014064	ATP binding site [chemical binding]; other site
223283014065	Q-loop/lid; other site
223283014066	ABC transporter signature motif; other site
223283014067	Walker B; other site
223283014068	D-loop; other site
223283014069	H-loop/switch region; other site
223283014070	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283014071	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
223283014072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283014073	dimer interface [polypeptide binding]; other site
223283014074	conserved gate region; other site
223283014075	putative PBP binding loops; other site
223283014076	ABC-ATPase subunit interface; other site
223283014077	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
223283014078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283014079	dimer interface [polypeptide binding]; other site
223283014080	conserved gate region; other site
223283014081	putative PBP binding loops; other site
223283014082	ABC-ATPase subunit interface; other site
223283014083	Autoinducer binding domain; Region: Autoind_bind; pfam03472
223283014084	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283014085	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283014086	DNA binding residues [nucleotide binding]
223283014087	dimerization interface [polypeptide binding]; other site
223283014088	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
223283014089	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283014090	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283014091	HAMP domain; Region: HAMP; pfam00672
223283014092	dimerization interface [polypeptide binding]; other site
223283014093	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283014094	dimer interface [polypeptide binding]; other site
223283014095	putative CheW interface [polypeptide binding]; other site
223283014096	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
223283014097	GAF domain; Region: GAF_2; pfam13185
223283014098	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
223283014099	GAF domain; Region: GAF; pfam01590
223283014100	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283014101	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283014102	metal binding site [ion binding]; metal-binding site
223283014103	active site
223283014104	I-site; other site
223283014105	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283014106	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
223283014107	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
223283014108	galactarate dehydratase; Region: galactar-dH20; TIGR03248
223283014109	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
223283014110	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
223283014111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283014112	D-galactonate transporter; Region: 2A0114; TIGR00893
223283014113	putative substrate translocation pore; other site
223283014114	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
223283014115	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
223283014116	putative active site [active]
223283014117	catalytic residue [active]
223283014118	Transcriptional regulators [Transcription]; Region: FadR; COG2186
223283014119	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283014120	DNA-binding site [nucleotide binding]; DNA binding site
223283014121	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
223283014122	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
223283014123	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
223283014124	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
223283014125	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
223283014126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283014127	active site
223283014128	phosphorylation site [posttranslational modification]
223283014129	intermolecular recognition site; other site
223283014130	dimerization interface [polypeptide binding]; other site
223283014131	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283014132	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283014133	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
223283014134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283014135	ATP binding site [chemical binding]; other site
223283014136	G-X-G motif; other site
223283014137	Protein of unknown function (DUF541); Region: SIMPL; cl01077
223283014138	Heterokaryon incompatibility protein Het-C; Region: Het-C; pfam07217
223283014139	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
223283014140	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
223283014141	peptide binding site [polypeptide binding]; other site
223283014142	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
223283014143	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
223283014144	peptide binding site [polypeptide binding]; other site
223283014145	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
223283014146	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
223283014147	peptide binding site [polypeptide binding]; other site
223283014148	outer membrane porin, OprD family; Region: OprD; pfam03573
223283014149	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
223283014150	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
223283014151	peptide binding site [polypeptide binding]; other site
223283014152	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
223283014153	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283014154	dimer interface [polypeptide binding]; other site
223283014155	conserved gate region; other site
223283014156	putative PBP binding loops; other site
223283014157	ABC-ATPase subunit interface; other site
223283014158	dipeptide transporter; Provisional; Region: PRK10913
223283014159	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
223283014160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283014161	putative PBP binding loops; other site
223283014162	dimer interface [polypeptide binding]; other site
223283014163	ABC-ATPase subunit interface; other site
223283014164	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
223283014165	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
223283014166	Walker A/P-loop; other site
223283014167	ATP binding site [chemical binding]; other site
223283014168	Q-loop/lid; other site
223283014169	ABC transporter signature motif; other site
223283014170	Walker B; other site
223283014171	D-loop; other site
223283014172	H-loop/switch region; other site
223283014173	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
223283014174	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283014175	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283014176	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283014177	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283014178	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283014179	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283014180	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283014181	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
223283014182	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
223283014183	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
223283014184	Flavodoxin; Region: Flavodoxin_1; pfam00258
223283014185	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
223283014186	FAD binding pocket [chemical binding]; other site
223283014187	FAD binding motif [chemical binding]; other site
223283014188	catalytic residues [active]
223283014189	NAD binding pocket [chemical binding]; other site
223283014190	phosphate binding motif [ion binding]; other site
223283014191	beta-alpha-beta structure motif; other site
223283014192	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
223283014193	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
223283014194	active site
223283014195	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
223283014196	dimer interface [polypeptide binding]; other site
223283014197	catalytic residues [active]
223283014198	substrate binding site [chemical binding]; other site
223283014199	Peptidase M60-like family; Region: M60-like; pfam13402
223283014200	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
223283014201	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
223283014202	Walker A/P-loop; other site
223283014203	ATP binding site [chemical binding]; other site
223283014204	Q-loop/lid; other site
223283014205	ABC transporter signature motif; other site
223283014206	Walker B; other site
223283014207	D-loop; other site
223283014208	H-loop/switch region; other site
223283014209	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
223283014210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283014211	dimer interface [polypeptide binding]; other site
223283014212	conserved gate region; other site
223283014213	ABC-ATPase subunit interface; other site
223283014214	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
223283014215	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
223283014216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283014217	dimer interface [polypeptide binding]; other site
223283014218	conserved gate region; other site
223283014219	putative PBP binding loops; other site
223283014220	ABC-ATPase subunit interface; other site
223283014221	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
223283014222	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
223283014223	G1 box; other site
223283014224	putative GEF interaction site [polypeptide binding]; other site
223283014225	GTP/Mg2+ binding site [chemical binding]; other site
223283014226	Switch I region; other site
223283014227	G2 box; other site
223283014228	G3 box; other site
223283014229	Switch II region; other site
223283014230	G4 box; other site
223283014231	G5 box; other site
223283014232	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
223283014233	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
223283014234	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
223283014235	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
223283014236	hypothetical protein; Provisional; Region: PRK05208
223283014237	AAA domain; Region: AAA_32; pfam13654
223283014238	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
223283014239	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
223283014240	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
223283014241	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
223283014242	NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129
223283014243	NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129
223283014244	Transposase domain (DUF772); Region: DUF772; pfam05598
223283014245	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283014246	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283014247	Tir chaperone protein (CesT) family; Region: CesT; cl08444
223283014248	transcription elongation factor regulatory protein; Validated; Region: PRK06342
223283014249	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
223283014250	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
223283014251	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283014252	Walker A/P-loop; other site
223283014253	ATP binding site [chemical binding]; other site
223283014254	Q-loop/lid; other site
223283014255	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
223283014256	ABC transporter signature motif; other site
223283014257	Walker B; other site
223283014258	D-loop; other site
223283014259	ABC transporter; Region: ABC_tran_2; pfam12848
223283014260	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
223283014261	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283014262	active site
223283014263	catalytic residues [active]
223283014264	Int/Topo IB signature motif; other site
223283014265	DNA binding site [nucleotide binding]
223283014266	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
223283014267	active site
223283014268	Int/Topo IB signature motif; other site
223283014269	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
223283014270	DNA binding site [nucleotide binding]
223283014271	active site
223283014272	Int/Topo IB signature motif; other site
223283014273	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
223283014274	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
223283014275	active site
223283014276	DNA binding site [nucleotide binding]
223283014277	Int/Topo IB signature motif; other site
223283014278	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
223283014279	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
223283014280	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
223283014281	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
223283014282	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
223283014283	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
223283014284	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283014285	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
223283014286	putative dimerization interface [polypeptide binding]; other site
223283014287	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
223283014288	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
223283014289	gating phenylalanine in ion channel; other site
223283014290	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
223283014291	putative uracil binding site [chemical binding]; other site
223283014292	putative active site [active]
223283014293	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
223283014294	dimer interface [polypeptide binding]; other site
223283014295	substrate binding site [chemical binding]; other site
223283014296	metal binding sites [ion binding]; metal-binding site
223283014297	enolase; Provisional; Region: eno; PRK00077
223283014298	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
223283014299	dimer interface [polypeptide binding]; other site
223283014300	metal binding site [ion binding]; metal-binding site
223283014301	substrate binding pocket [chemical binding]; other site
223283014302	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
223283014303	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
223283014304	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
223283014305	putative Cl- selectivity filter; other site
223283014306	putative pore gating glutamate residue; other site
223283014307	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
223283014308	Sodium Bile acid symporter family; Region: SBF; cl17470
223283014309	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
223283014310	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
223283014311	DNA binding residues [nucleotide binding]
223283014312	dimer interface [polypeptide binding]; other site
223283014313	putative metal binding site [ion binding]; other site
223283014314	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
223283014315	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283014316	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283014317	dimerization interface [polypeptide binding]; other site
223283014318	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283014319	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283014320	dimer interface [polypeptide binding]; other site
223283014321	putative CheW interface [polypeptide binding]; other site
223283014322	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283014323	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283014324	DNA-binding interface [nucleotide binding]; DNA binding site
223283014325	Integrase core domain; Region: rve; pfam00665
223283014326	Integrase core domain; Region: rve_3; cl15866
223283014327	transposase/IS protein; Provisional; Region: PRK09183
223283014328	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283014329	Walker A motif; other site
223283014330	ATP binding site [chemical binding]; other site
223283014331	Walker B motif; other site
223283014332	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
223283014333	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283014334	non-specific DNA binding site [nucleotide binding]; other site
223283014335	salt bridge; other site
223283014336	sequence-specific DNA binding site [nucleotide binding]; other site
223283014337	PAS domain S-box; Region: sensory_box; TIGR00229
223283014338	PAS domain S-box; Region: sensory_box; TIGR00229
223283014339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283014340	putative active site [active]
223283014341	heme pocket [chemical binding]; other site
223283014342	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283014343	PAS domain; Region: PAS_9; pfam13426
223283014344	putative active site [active]
223283014345	heme pocket [chemical binding]; other site
223283014346	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283014347	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283014348	metal binding site [ion binding]; metal-binding site
223283014349	active site
223283014350	I-site; other site
223283014351	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283014352	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
223283014353	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
223283014354	dimer interface [polypeptide binding]; other site
223283014355	active site
223283014356	glycine-pyridoxal phosphate binding site [chemical binding]; other site
223283014357	folate binding site [chemical binding]; other site
223283014358	PAAR motif; Region: PAAR_motif; pfam05488
223283014359	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
223283014360	amidase catalytic site [active]
223283014361	Zn binding residues [ion binding]; other site
223283014362	substrate binding site [chemical binding]; other site
223283014363	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
223283014364	putative active site [active]
223283014365	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
223283014366	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
223283014367	P-loop, Walker A motif; other site
223283014368	Base recognition motif; other site
223283014369	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
223283014370	Uncharacterized small protein [Function unknown]; Region: COG2879
223283014371	carbon starvation protein A; Provisional; Region: PRK15015
223283014372	Carbon starvation protein CstA; Region: CstA; pfam02554
223283014373	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
223283014374	PilZ domain; Region: PilZ; pfam07238
223283014375	DNA repair protein RadA; Provisional; Region: PRK11823
223283014376	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
223283014377	Walker A motif/ATP binding site; other site
223283014378	ATP binding site [chemical binding]; other site
223283014379	Walker B motif; other site
223283014380	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
223283014381	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
223283014382	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
223283014383	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
223283014384	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
223283014385	FAD binding pocket [chemical binding]; other site
223283014386	FAD binding motif [chemical binding]; other site
223283014387	phosphate binding motif [ion binding]; other site
223283014388	beta-alpha-beta structure motif; other site
223283014389	NAD binding pocket [chemical binding]; other site
223283014390	Transposase domain (DUF772); Region: DUF772; pfam05598
223283014391	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283014392	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283014393	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283014394	DNA binding residues [nucleotide binding]
223283014395	dimerization interface [polypeptide binding]; other site
223283014396	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
223283014397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283014398	S-adenosylmethionine binding site [chemical binding]; other site
223283014399	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
223283014400	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
223283014401	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
223283014402	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
223283014403	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
223283014404	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
223283014405	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
223283014406	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
223283014407	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
223283014408	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
223283014409	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
223283014410	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
223283014411	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
223283014412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283014413	S-adenosylmethionine binding site [chemical binding]; other site
223283014414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283014415	H+ Antiporter protein; Region: 2A0121; TIGR00900
223283014416	putative substrate translocation pore; other site
223283014417	Predicted metalloprotease [General function prediction only]; Region: COG2321
223283014418	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
223283014419	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
223283014420	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283014421	motif II; other site
223283014422	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
223283014423	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
223283014424	active site
223283014425	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
223283014426	catalytic triad [active]
223283014427	dimer interface [polypeptide binding]; other site
223283014428	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
223283014429	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
223283014430	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
223283014431	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
223283014432	putative active site [active]
223283014433	Zn binding site [ion binding]; other site
223283014434	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
223283014435	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
223283014436	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
223283014437	DEAD-like helicases superfamily; Region: DEXDc; smart00487
223283014438	ATP binding site [chemical binding]; other site
223283014439	Mg++ binding site [ion binding]; other site
223283014440	motif III; other site
223283014441	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283014442	nucleotide binding region [chemical binding]; other site
223283014443	ATP-binding site [chemical binding]; other site
223283014444	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
223283014445	active site
223283014446	catalytic site [active]
223283014447	substrate binding site [chemical binding]; other site
223283014448	Uncharacterized conserved protein [Function unknown]; Region: COG1432
223283014449	LabA_like proteins; Region: LabA; cd10911
223283014450	putative metal binding site [ion binding]; other site
223283014451	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
223283014452	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
223283014453	Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642
223283014454	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
223283014455	putative catalytic site [active]
223283014456	putative metal binding site [ion binding]; other site
223283014457	putative phosphate binding site [ion binding]; other site
223283014458	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
223283014459	Beta-lactamase; Region: Beta-lactamase; pfam00144
223283014460	NAD-dependent deacetylase; Provisional; Region: PRK00481
223283014461	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
223283014462	NAD+ binding site [chemical binding]; other site
223283014463	substrate binding site [chemical binding]; other site
223283014464	Zn binding site [ion binding]; other site
223283014465	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
223283014466	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
223283014467	acyl-activating enzyme (AAE) consensus motif; other site
223283014468	AMP binding site [chemical binding]; other site
223283014469	active site
223283014470	CoA binding site [chemical binding]; other site
223283014471	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
223283014472	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
223283014473	active site 2 [active]
223283014474	active site 1 [active]
223283014475	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
223283014476	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
223283014477	dimer interface [polypeptide binding]; other site
223283014478	active site
223283014479	AMP-binding enzyme; Region: AMP-binding; pfam00501
223283014480	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
223283014481	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
223283014482	acyl-activating enzyme (AAE) consensus motif; other site
223283014483	acyl-activating enzyme (AAE) consensus motif; other site
223283014484	active site
223283014485	AMP binding site [chemical binding]; other site
223283014486	CoA binding site [chemical binding]; other site
223283014487	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
223283014488	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
223283014489	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
223283014490	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
223283014491	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
223283014492	active site
223283014493	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
223283014494	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
223283014495	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
223283014496	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
223283014497	Enoylreductase; Region: PKS_ER; smart00829
223283014498	NAD(P) binding site [chemical binding]; other site
223283014499	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
223283014500	putative NADP binding site [chemical binding]; other site
223283014501	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
223283014502	active site
223283014503	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
223283014504	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
223283014505	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
223283014506	active site
223283014507	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
223283014508	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
223283014509	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
223283014510	putative NADP binding site [chemical binding]; other site
223283014511	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
223283014512	active site
223283014513	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
223283014514	Thioesterase; Region: PKS_TE; smart00824
223283014515	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
223283014516	active site 2 [active]
223283014517	active site 1 [active]
223283014518	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
223283014519	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
223283014520	putative NAD(P) binding site [chemical binding]; other site
223283014521	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
223283014522	HI0933-like protein; Region: HI0933_like; pfam03486
223283014523	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283014524	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283014525	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283014526	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283014527	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283014528	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283014529	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283014530	Transposase; Region: HTH_Tnp_1; cl17663
223283014531	putative transposase OrfB; Reviewed; Region: PHA02517
223283014532	HTH-like domain; Region: HTH_21; pfam13276
223283014533	Integrase core domain; Region: rve; pfam00665
223283014534	Integrase core domain; Region: rve_3; cl15866
223283014535	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283014536	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
223283014537	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
223283014538	Condensation domain; Region: Condensation; pfam00668
223283014539	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283014540	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
223283014541	acyl-activating enzyme (AAE) consensus motif; other site
223283014542	AMP binding site [chemical binding]; other site
223283014543	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283014544	Condensation domain; Region: Condensation; pfam00668
223283014545	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283014546	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283014547	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283014548	acyl-activating enzyme (AAE) consensus motif; other site
223283014549	AMP binding site [chemical binding]; other site
223283014550	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283014551	Condensation domain; Region: Condensation; pfam00668
223283014552	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283014553	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
223283014554	acyl-activating enzyme (AAE) consensus motif; other site
223283014555	AMP binding site [chemical binding]; other site
223283014556	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283014557	Condensation domain; Region: Condensation; pfam00668
223283014558	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
223283014559	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
223283014560	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283014561	acyl-activating enzyme (AAE) consensus motif; other site
223283014562	AMP binding site [chemical binding]; other site
223283014563	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283014564	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
223283014565	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
223283014566	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283014567	Transposase domain (DUF772); Region: DUF772; pfam05598
223283014568	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283014569	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283014570	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283014571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283014572	active site
223283014573	phosphorylation site [posttranslational modification]
223283014574	intermolecular recognition site; other site
223283014575	dimerization interface [polypeptide binding]; other site
223283014576	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283014577	DNA binding residues [nucleotide binding]
223283014578	dimerization interface [polypeptide binding]; other site
223283014579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283014580	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
223283014581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283014582	ATP binding site [chemical binding]; other site
223283014583	Mg2+ binding site [ion binding]; other site
223283014584	G-X-G motif; other site
223283014585	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283014586	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283014587	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
223283014588	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
223283014589	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
223283014590	acyl-activating enzyme (AAE) consensus motif; other site
223283014591	AMP binding site [chemical binding]; other site
223283014592	active site
223283014593	CoA binding site [chemical binding]; other site
223283014594	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
223283014595	chlorinating enzyme; Region: chlorin-enz; TIGR01762
223283014596	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
223283014597	active site
223283014598	Thioesterase domain; Region: Thioesterase; pfam00975
223283014599	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
223283014600	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
223283014601	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
223283014602	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
223283014603	Tir chaperone protein (CesT) family; Region: CesT; cl08444
223283014604	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
223283014605	active site
223283014606	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
223283014607	Transposase domain (DUF772); Region: DUF772; pfam05598
223283014608	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283014609	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
223283014610	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283014611	transposase/IS protein; Provisional; Region: PRK09183
223283014612	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283014613	Walker A motif; other site
223283014614	ATP binding site [chemical binding]; other site
223283014615	Walker B motif; other site
223283014616	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283014617	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283014618	DNA-binding interface [nucleotide binding]; DNA binding site
223283014619	Integrase core domain; Region: rve; pfam00665
223283014620	Integrase core domain; Region: rve_3; cl15866
223283014621	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
223283014622	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
223283014623	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283014624	ATP binding site [chemical binding]; other site
223283014625	putative Mg++ binding site [ion binding]; other site
223283014626	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283014627	nucleotide binding region [chemical binding]; other site
223283014628	ATP-binding site [chemical binding]; other site
223283014629	Helicase associated domain (HA2); Region: HA2; pfam04408
223283014630	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
223283014631	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283014632	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283014633	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283014634	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283014635	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283014636	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283014637	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283014638	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
223283014639	DNA binding site [nucleotide binding]
223283014640	active site
223283014641	Int/Topo IB signature motif; other site
223283014642	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283014643	active site
223283014644	catalytic residues [active]
223283014645	DNA binding site [nucleotide binding]
223283014646	Int/Topo IB signature motif; other site
223283014647	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
223283014648	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283014649	nucleotide binding region [chemical binding]; other site
223283014650	ATP-binding site [chemical binding]; other site
223283014651	Helicase associated domain (HA2); Region: HA2; pfam04408
223283014652	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
223283014653	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283014654	active site
223283014655	catalytic residues [active]
223283014656	DNA binding site [nucleotide binding]
223283014657	Int/Topo IB signature motif; other site
223283014658	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
223283014659	Part of AAA domain; Region: AAA_19; pfam13245
223283014660	Family description; Region: UvrD_C_2; pfam13538
223283014661	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
223283014662	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
223283014663	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283014664	non-specific DNA binding site [nucleotide binding]; other site
223283014665	salt bridge; other site
223283014666	sequence-specific DNA binding site [nucleotide binding]; other site
223283014667	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
223283014668	active site
223283014669	ATP binding site [chemical binding]; other site
223283014670	substrate binding site [chemical binding]; other site
223283014671	activation loop (A-loop); other site
223283014672	VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464
223283014673	metal ion-dependent adhesion site (MIDAS); other site
223283014674	Protein phosphatase 2C; Region: PP2C_2; pfam13672
223283014675	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283014676	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283014677	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283014678	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283014679	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283014680	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283014681	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283014682	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
223283014683	transposase/IS protein; Provisional; Region: PRK09183
223283014684	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283014685	Walker A motif; other site
223283014686	ATP binding site [chemical binding]; other site
223283014687	Walker B motif; other site
223283014688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283014689	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283014690	DNA-binding interface [nucleotide binding]; DNA binding site
223283014691	Integrase core domain; Region: rve; pfam00665
223283014692	Integrase core domain; Region: rve_3; cl15866
223283014693	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
223283014694	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
223283014695	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283014696	ATP binding site [chemical binding]; other site
223283014697	putative Mg++ binding site [ion binding]; other site
223283014698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283014699	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283014700	putative substrate translocation pore; other site
223283014701	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
223283014702	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283014703	DNA-binding site [nucleotide binding]; DNA binding site
223283014704	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283014705	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283014706	homodimer interface [polypeptide binding]; other site
223283014707	catalytic residue [active]
223283014708	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
223283014709	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
223283014710	HSP70 interaction site [polypeptide binding]; other site
223283014711	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
223283014712	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
223283014713	putative C-terminal domain interface [polypeptide binding]; other site
223283014714	putative GSH binding site (G-site) [chemical binding]; other site
223283014715	putative dimer interface [polypeptide binding]; other site
223283014716	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
223283014717	putative N-terminal domain interface [polypeptide binding]; other site
223283014718	putative dimer interface [polypeptide binding]; other site
223283014719	putative substrate binding pocket (H-site) [chemical binding]; other site
223283014720	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
223283014721	homotrimer interaction site [polypeptide binding]; other site
223283014722	putative active site [active]
223283014723	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
223283014724	Family of unknown function (DUF633); Region: DUF633; pfam04816
223283014725	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
223283014726	catalytic residues [active]
223283014727	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
223283014728	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
223283014729	Serine hydrolase (FSH1); Region: FSH1; pfam03959
223283014730	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
223283014731	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
223283014732	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
223283014733	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283014734	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283014735	metal binding site [ion binding]; metal-binding site
223283014736	active site
223283014737	I-site; other site
223283014738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283014739	PAS domain; Region: PAS_9; pfam13426
223283014740	putative active site [active]
223283014741	heme pocket [chemical binding]; other site
223283014742	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283014743	PAS domain; Region: PAS_9; pfam13426
223283014744	putative active site [active]
223283014745	heme pocket [chemical binding]; other site
223283014746	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283014747	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283014748	dimer interface [polypeptide binding]; other site
223283014749	putative CheW interface [polypeptide binding]; other site
223283014750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283014751	dimer interface [polypeptide binding]; other site
223283014752	phosphorylation site [posttranslational modification]
223283014753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283014754	ATP binding site [chemical binding]; other site
223283014755	Mg2+ binding site [ion binding]; other site
223283014756	G-X-G motif; other site
223283014757	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
223283014758	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
223283014759	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
223283014760	Cation efflux family; Region: Cation_efflux; cl00316
223283014761	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
223283014762	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
223283014763	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283014764	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
223283014765	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
223283014766	putative DNA binding site [nucleotide binding]; other site
223283014767	putative Zn2+ binding site [ion binding]; other site
223283014768	AsnC family; Region: AsnC_trans_reg; pfam01037
223283014769	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
223283014770	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
223283014771	probable active site [active]
223283014772	AMP nucleosidase; Provisional; Region: PRK08292
223283014773	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
223283014774	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
223283014775	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
223283014776	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
223283014777	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283014778	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283014779	dimer interface [polypeptide binding]; other site
223283014780	phosphorylation site [posttranslational modification]
223283014781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283014782	ATP binding site [chemical binding]; other site
223283014783	Mg2+ binding site [ion binding]; other site
223283014784	G-X-G motif; other site
223283014785	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
223283014786	dimer interface [polypeptide binding]; other site
223283014787	substrate binding site [chemical binding]; other site
223283014788	ATP binding site [chemical binding]; other site
223283014789	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
223283014790	thiamine phosphate binding site [chemical binding]; other site
223283014791	active site
223283014792	pyrophosphate binding site [ion binding]; other site
223283014793	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
223283014794	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283014795	inhibitor-cofactor binding pocket; inhibition site
223283014796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283014797	catalytic residue [active]
223283014798	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
223283014799	Sel1-like repeats; Region: SEL1; smart00671
223283014800	Sel1-like repeats; Region: SEL1; smart00671
223283014801	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
223283014802	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
223283014803	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
223283014804	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283014805	FeS/SAM binding site; other site
223283014806	TRAM domain; Region: TRAM; pfam01938
223283014807	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
223283014808	PhoH-like protein; Region: PhoH; pfam02562
223283014809	metal-binding heat shock protein; Provisional; Region: PRK00016
223283014810	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
223283014811	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
223283014812	Transporter associated domain; Region: CorC_HlyC; smart01091
223283014813	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
223283014814	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
223283014815	putative active site [active]
223283014816	catalytic triad [active]
223283014817	putative dimer interface [polypeptide binding]; other site
223283014818	Uncharacterized conserved protein [Function unknown]; Region: COG1434
223283014819	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
223283014820	putative active site [active]
223283014821	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
223283014822	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
223283014823	HIGH motif; other site
223283014824	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
223283014825	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
223283014826	active site
223283014827	KMSKS motif; other site
223283014828	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
223283014829	tRNA binding surface [nucleotide binding]; other site
223283014830	Lipopolysaccharide-assembly; Region: LptE; cl01125
223283014831	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
223283014832	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
223283014833	Domain of unknown function; Region: DUF331; cl01149
223283014834	Transglycosylase SLT domain; Region: SLT_2; pfam13406
223283014835	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283014836	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283014837	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
223283014838	lipoyl synthase; Provisional; Region: PRK05481
223283014839	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283014840	FeS/SAM binding site; other site
223283014841	lipoate-protein ligase B; Provisional; Region: PRK14342
223283014842	hypothetical protein; Provisional; Region: PRK00341
223283014843	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
223283014844	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
223283014845	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
223283014846	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
223283014847	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
223283014848	Sporulation related domain; Region: SPOR; pfam05036
223283014849	Transglycosylase SLT domain; Region: SLT_2; pfam13406
223283014850	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283014851	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283014852	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
223283014853	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
223283014854	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
223283014855	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
223283014856	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
223283014857	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
223283014858	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
223283014859	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
223283014860	active site
223283014861	(T/H)XGH motif; other site
223283014862	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
223283014863	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
223283014864	putative catalytic cysteine [active]
223283014865	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
223283014866	active site
223283014867	DNA binding site [nucleotide binding]
223283014868	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
223283014869	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
223283014870	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
223283014871	active site
223283014872	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
223283014873	Predicted membrane protein [Function unknown]; Region: COG4655
223283014874	PAS fold; Region: PAS_3; pfam08447
223283014875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283014876	putative active site [active]
223283014877	heme pocket [chemical binding]; other site
223283014878	PAS domain; Region: PAS; smart00091
223283014879	PAS fold; Region: PAS_4; pfam08448
223283014880	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283014881	dimer interface [polypeptide binding]; other site
223283014882	phosphorylation site [posttranslational modification]
223283014883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283014884	ATP binding site [chemical binding]; other site
223283014885	Mg2+ binding site [ion binding]; other site
223283014886	G-X-G motif; other site
223283014887	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
223283014888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283014889	active site
223283014890	phosphorylation site [posttranslational modification]
223283014891	intermolecular recognition site; other site
223283014892	dimerization interface [polypeptide binding]; other site
223283014893	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283014894	DNA binding residues [nucleotide binding]
223283014895	dimerization interface [polypeptide binding]; other site
223283014896	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
223283014897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283014898	active site
223283014899	phosphorylation site [posttranslational modification]
223283014900	intermolecular recognition site; other site
223283014901	dimerization interface [polypeptide binding]; other site
223283014902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283014903	active site
223283014904	phosphorylation site [posttranslational modification]
223283014905	intermolecular recognition site; other site
223283014906	dimerization interface [polypeptide binding]; other site
223283014907	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283014908	metal binding site [ion binding]; metal-binding site
223283014909	active site
223283014910	I-site; other site
223283014911	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
223283014912	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
223283014913	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
223283014914	nudix motif; other site
223283014915	translation initiation factor Sui1; Validated; Region: PRK06824
223283014916	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
223283014917	putative rRNA binding site [nucleotide binding]; other site
223283014918	arginine decarboxylase; Provisional; Region: PRK05354
223283014919	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
223283014920	dimer interface [polypeptide binding]; other site
223283014921	active site
223283014922	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
223283014923	catalytic residues [active]
223283014924	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
223283014925	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
223283014926	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
223283014927	substrate binding pocket [chemical binding]; other site
223283014928	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
223283014929	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
223283014930	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
223283014931	MG2 domain; Region: A2M_N; pfam01835
223283014932	Alpha-2-macroglobulin family; Region: A2M; pfam00207
223283014933	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
223283014934	surface patch; other site
223283014935	thioester region; other site
223283014936	specificity defining residues; other site
223283014937	penicillin-binding protein 1C; Provisional; Region: PRK11240
223283014938	Transglycosylase; Region: Transgly; pfam00912
223283014939	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
223283014940	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
223283014941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283014942	active site
223283014943	phosphorylation site [posttranslational modification]
223283014944	intermolecular recognition site; other site
223283014945	dimerization interface [polypeptide binding]; other site
223283014946	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
223283014947	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
223283014948	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
223283014949	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
223283014950	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
223283014951	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
223283014952	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
223283014953	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
223283014954	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
223283014955	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
223283014956	ATP binding site [chemical binding]; other site
223283014957	Walker A motif; other site
223283014958	hexamer interface [polypeptide binding]; other site
223283014959	Walker B motif; other site
223283014960	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
223283014961	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
223283014962	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
223283014963	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
223283014964	TPR repeat; Region: TPR_11; pfam13414
223283014965	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
223283014966	binding surface
223283014967	TPR motif; other site
223283014968	TPR repeat; Region: TPR_11; pfam13414
223283014969	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
223283014970	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
223283014971	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
223283014972	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
223283014973	DsbD alpha interface [polypeptide binding]; other site
223283014974	catalytic residues [active]
223283014975	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
223283014976	Dehydroquinase class II; Region: DHquinase_II; pfam01220
223283014977	trimer interface [polypeptide binding]; other site
223283014978	active site
223283014979	dimer interface [polypeptide binding]; other site
223283014980	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
223283014981	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
223283014982	carboxyltransferase (CT) interaction site; other site
223283014983	biotinylation site [posttranslational modification]; other site
223283014984	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
223283014985	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
223283014986	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
223283014987	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
223283014988	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
223283014989	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283014990	S-adenosylmethionine binding site [chemical binding]; other site
223283014991	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
223283014992	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
223283014993	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
223283014994	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
223283014995	FMN binding site [chemical binding]; other site
223283014996	active site
223283014997	catalytic residues [active]
223283014998	substrate binding site [chemical binding]; other site
223283014999	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
223283015000	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
223283015001	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
223283015002	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
223283015003	purine monophosphate binding site [chemical binding]; other site
223283015004	dimer interface [polypeptide binding]; other site
223283015005	putative catalytic residues [active]
223283015006	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
223283015007	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
223283015008	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
223283015009	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
223283015010	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
223283015011	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
223283015012	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
223283015013	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
223283015014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283015015	dimer interface [polypeptide binding]; other site
223283015016	phosphorylation site [posttranslational modification]
223283015017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283015018	ATP binding site [chemical binding]; other site
223283015019	Mg2+ binding site [ion binding]; other site
223283015020	G-X-G motif; other site
223283015021	Response regulator receiver domain; Region: Response_reg; pfam00072
223283015022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283015023	active site
223283015024	phosphorylation site [posttranslational modification]
223283015025	intermolecular recognition site; other site
223283015026	dimerization interface [polypeptide binding]; other site
223283015027	Response regulator receiver domain; Region: Response_reg; pfam00072
223283015028	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283015029	active site
223283015030	phosphorylation site [posttranslational modification]
223283015031	intermolecular recognition site; other site
223283015032	dimerization interface [polypeptide binding]; other site
223283015033	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
223283015034	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
223283015035	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
223283015036	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
223283015037	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
223283015038	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
223283015039	active site
223283015040	SAM binding site [chemical binding]; other site
223283015041	homodimer interface [polypeptide binding]; other site
223283015042	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
223283015043	active site
223283015044	SAM binding site [chemical binding]; other site
223283015045	homodimer interface [polypeptide binding]; other site
223283015046	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
223283015047	Precorrin-8X methylmutase; Region: CbiC; pfam02570
223283015048	precorrin-3B synthase; Region: CobG; TIGR02435
223283015049	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
223283015050	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
223283015051	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
223283015052	active site
223283015053	putative homodimer interface [polypeptide binding]; other site
223283015054	SAM binding site [chemical binding]; other site
223283015055	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
223283015056	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283015057	S-adenosylmethionine binding site [chemical binding]; other site
223283015058	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
223283015059	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
223283015060	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
223283015061	Protein of unknown function (DUF461); Region: DUF461; pfam04314
223283015062	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
223283015063	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
223283015064	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
223283015065	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
223283015066	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
223283015067	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
223283015068	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
223283015069	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
223283015070	putative ligand binding site [chemical binding]; other site
223283015071	HEAT repeats; Region: HEAT_2; pfam13646
223283015072	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
223283015073	TM-ABC transporter signature motif; other site
223283015074	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
223283015075	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
223283015076	TM-ABC transporter signature motif; other site
223283015077	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
223283015078	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
223283015079	Walker A/P-loop; other site
223283015080	ATP binding site [chemical binding]; other site
223283015081	Q-loop/lid; other site
223283015082	ABC transporter signature motif; other site
223283015083	Walker B; other site
223283015084	D-loop; other site
223283015085	H-loop/switch region; other site
223283015086	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
223283015087	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
223283015088	Walker A/P-loop; other site
223283015089	ATP binding site [chemical binding]; other site
223283015090	Q-loop/lid; other site
223283015091	ABC transporter signature motif; other site
223283015092	Walker B; other site
223283015093	D-loop; other site
223283015094	H-loop/switch region; other site
223283015095	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
223283015096	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
223283015097	alpha-gamma subunit interface [polypeptide binding]; other site
223283015098	beta-gamma subunit interface [polypeptide binding]; other site
223283015099	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
223283015100	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283015101	Coenzyme A binding pocket [chemical binding]; other site
223283015102	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
223283015103	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283015104	Coenzyme A binding pocket [chemical binding]; other site
223283015105	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
223283015106	gamma-beta subunit interface [polypeptide binding]; other site
223283015107	alpha-beta subunit interface [polypeptide binding]; other site
223283015108	urease subunit alpha; Reviewed; Region: ureC; PRK13207
223283015109	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
223283015110	subunit interactions [polypeptide binding]; other site
223283015111	active site
223283015112	flap region; other site
223283015113	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283015114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283015115	dimer interface [polypeptide binding]; other site
223283015116	phosphorylation site [posttranslational modification]
223283015117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283015118	ATP binding site [chemical binding]; other site
223283015119	Mg2+ binding site [ion binding]; other site
223283015120	G-X-G motif; other site
223283015121	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
223283015122	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
223283015123	HSP70 interaction site [polypeptide binding]; other site
223283015124	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
223283015125	substrate binding site [polypeptide binding]; other site
223283015126	dimer interface [polypeptide binding]; other site
223283015127	putative chaperone; Provisional; Region: PRK11678
223283015128	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
223283015129	nucleotide binding site [chemical binding]; other site
223283015130	putative NEF/HSP70 interaction site [polypeptide binding]; other site
223283015131	SBD interface [polypeptide binding]; other site
223283015132	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
223283015133	psiF repeat; Region: PsiF_repeat; pfam07769
223283015134	psiF repeat; Region: PsiF_repeat; pfam07769
223283015135	EamA-like transporter family; Region: EamA; pfam00892
223283015136	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
223283015137	EamA-like transporter family; Region: EamA; pfam00892
223283015138	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
223283015139	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283015140	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
223283015141	Ferritin-like domain; Region: Ferritin; pfam00210
223283015142	dinuclear metal binding motif [ion binding]; other site
223283015143	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
223283015144	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
223283015145	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
223283015146	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283015147	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
223283015148	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
223283015149	dimer interface [polypeptide binding]; other site
223283015150	catalytic residues [active]
223283015151	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
223283015152	UreF; Region: UreF; pfam01730
223283015153	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
223283015154	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
223283015155	dimerization interface [polypeptide binding]; other site
223283015156	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
223283015157	putative active cleft [active]
223283015158	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
223283015159	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
223283015160	putative NAD(P) binding site [chemical binding]; other site
223283015161	homotetramer interface [polypeptide binding]; other site
223283015162	homodimer interface [polypeptide binding]; other site
223283015163	active site
223283015164	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
223283015165	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
223283015166	Walker A/P-loop; other site
223283015167	ATP binding site [chemical binding]; other site
223283015168	Q-loop/lid; other site
223283015169	ABC transporter signature motif; other site
223283015170	Walker B; other site
223283015171	D-loop; other site
223283015172	H-loop/switch region; other site
223283015173	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
223283015174	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
223283015175	Walker A/P-loop; other site
223283015176	ATP binding site [chemical binding]; other site
223283015177	Q-loop/lid; other site
223283015178	ABC transporter signature motif; other site
223283015179	Walker B; other site
223283015180	D-loop; other site
223283015181	H-loop/switch region; other site
223283015182	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
223283015183	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
223283015184	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
223283015185	TM-ABC transporter signature motif; other site
223283015186	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
223283015187	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
223283015188	TM-ABC transporter signature motif; other site
223283015189	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
223283015190	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
223283015191	dimerization interface [polypeptide binding]; other site
223283015192	ligand binding site [chemical binding]; other site
223283015193	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
223283015194	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283015195	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
223283015196	dimerization interface [polypeptide binding]; other site
223283015197	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
223283015198	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
223283015199	active site
223283015200	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
223283015201	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
223283015202	homodimer interface [polypeptide binding]; other site
223283015203	NAD binding pocket [chemical binding]; other site
223283015204	ATP binding pocket [chemical binding]; other site
223283015205	Mg binding site [ion binding]; other site
223283015206	active-site loop [active]
223283015207	azurin; Region: azurin; TIGR02695
223283015208	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
223283015209	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
223283015210	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
223283015211	Uncharacterized conserved protein [Function unknown]; Region: COG2308
223283015212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
223283015213	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
223283015214	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
223283015215	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
223283015216	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
223283015217	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
223283015218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
223283015219	hypothetical protein; Provisional; Region: PRK01254
223283015220	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
223283015221	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
223283015222	replicative DNA helicase; Provisional; Region: PRK05748
223283015223	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
223283015224	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
223283015225	Walker A motif; other site
223283015226	ATP binding site [chemical binding]; other site
223283015227	Walker B motif; other site
223283015228	DNA binding loops [nucleotide binding]
223283015229	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
223283015230	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
223283015231	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
223283015232	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
223283015233	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
223283015234	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
223283015235	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
223283015236	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
223283015237	ribonuclease R; Region: RNase_R; TIGR02063
223283015238	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
223283015239	RNB domain; Region: RNB; pfam00773
223283015240	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
223283015241	RNA binding site [nucleotide binding]; other site
223283015242	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283015243	dimerization interface [polypeptide binding]; other site
223283015244	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283015245	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283015246	dimer interface [polypeptide binding]; other site
223283015247	putative CheW interface [polypeptide binding]; other site
223283015248	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
223283015249	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
223283015250	GDP-binding site [chemical binding]; other site
223283015251	ACT binding site; other site
223283015252	IMP binding site; other site
223283015253	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
223283015254	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
223283015255	dimer interface [polypeptide binding]; other site
223283015256	motif 1; other site
223283015257	active site
223283015258	motif 2; other site
223283015259	motif 3; other site
223283015260	HflC protein; Region: hflC; TIGR01932
223283015261	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
223283015262	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
223283015263	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
223283015264	HflK protein; Region: hflK; TIGR01933
223283015265	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
223283015266	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
223283015267	HflX GTPase family; Region: HflX; cd01878
223283015268	G1 box; other site
223283015269	GTP/Mg2+ binding site [chemical binding]; other site
223283015270	Switch I region; other site
223283015271	G2 box; other site
223283015272	G3 box; other site
223283015273	Switch II region; other site
223283015274	G4 box; other site
223283015275	G5 box; other site
223283015276	bacterial Hfq-like; Region: Hfq; cd01716
223283015277	hexamer interface [polypeptide binding]; other site
223283015278	Sm1 motif; other site
223283015279	RNA binding site [nucleotide binding]; other site
223283015280	Sm2 motif; other site
223283015281	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
223283015282	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
223283015283	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
223283015284	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283015285	ATP binding site [chemical binding]; other site
223283015286	Mg2+ binding site [ion binding]; other site
223283015287	G-X-G motif; other site
223283015288	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
223283015289	ATP binding site [chemical binding]; other site
223283015290	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
223283015291	AMIN domain; Region: AMIN; pfam11741
223283015292	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
223283015293	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
223283015294	active site
223283015295	metal binding site [ion binding]; metal-binding site
223283015296	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
223283015297	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
223283015298	putative carbohydrate kinase; Provisional; Region: PRK10565
223283015299	Uncharacterized conserved protein [Function unknown]; Region: COG0062
223283015300	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
223283015301	putative substrate binding site [chemical binding]; other site
223283015302	putative ATP binding site [chemical binding]; other site
223283015303	epoxyqueuosine reductase; Region: TIGR00276
223283015304	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
223283015305	Predicted membrane protein [Function unknown]; Region: COG2860
223283015306	UPF0126 domain; Region: UPF0126; pfam03458
223283015307	UPF0126 domain; Region: UPF0126; pfam03458
223283015308	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
223283015309	catalytic site [active]
223283015310	putative active site [active]
223283015311	putative substrate binding site [chemical binding]; other site
223283015312	dimer interface [polypeptide binding]; other site
223283015313	GTPase RsgA; Reviewed; Region: PRK12288
223283015314	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
223283015315	RNA binding site [nucleotide binding]; other site
223283015316	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
223283015317	GTPase/Zn-binding domain interface [polypeptide binding]; other site
223283015318	GTP/Mg2+ binding site [chemical binding]; other site
223283015319	G4 box; other site
223283015320	G5 box; other site
223283015321	G1 box; other site
223283015322	Switch I region; other site
223283015323	G2 box; other site
223283015324	G3 box; other site
223283015325	Switch II region; other site
223283015326	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
223283015327	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
223283015328	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
223283015329	ligand binding site [chemical binding]; other site
223283015330	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
223283015331	flagellar motor protein MotA; Validated; Region: PRK09110
223283015332	HDOD domain; Region: HDOD; pfam08668
223283015333	bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional; Region: PRK09629
223283015334	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
223283015335	active site residue [active]
223283015336	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
223283015337	active site residue [active]
223283015338	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
223283015339	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
223283015340	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
223283015341	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
223283015342	phosphoserine phosphatase SerB; Region: serB; TIGR00338
223283015343	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283015344	motif II; other site
223283015345	Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726
223283015346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
223283015347	Protein of unknown function (DUF330); Region: DUF330; pfam03886
223283015348	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
223283015349	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
223283015350	CAP-like domain; other site
223283015351	active site
223283015352	primary dimer interface [polypeptide binding]; other site
223283015353	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
223283015354	catalytic motif [active]
223283015355	Catalytic residue [active]
223283015356	SdiA-regulated; Region: SdiA-regulated; cd09971
223283015357	putative active site [active]
223283015358	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
223283015359	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283015360	ATP binding site [chemical binding]; other site
223283015361	Mg2+ binding site [ion binding]; other site
223283015362	G-X-G motif; other site
223283015363	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
223283015364	anchoring element; other site
223283015365	dimer interface [polypeptide binding]; other site
223283015366	ATP binding site [chemical binding]; other site
223283015367	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
223283015368	active site
223283015369	metal binding site [ion binding]; metal-binding site
223283015370	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
223283015371	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
223283015372	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
223283015373	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
223283015374	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
223283015375	active site
223283015376	metal binding site [ion binding]; metal-binding site
223283015377	hexamer interface [polypeptide binding]; other site
223283015378	Protein of unkown function (DUF1881); Region: DUF1881; pfam08964
223283015379	potential frameshift: common BLAST hit: gi|188535141|ref|YP_001908938.1| Nematicidal protein
223283015380	N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211
223283015381	RHS Repeat; Region: RHS_repeat; cl11982
223283015382	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
223283015383	Transposase domain (DUF772); Region: DUF772; pfam05598
223283015384	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283015385	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283015386	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
223283015387	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
223283015388	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
223283015389	dimer interface [polypeptide binding]; other site
223283015390	ADP-ribose binding site [chemical binding]; other site
223283015391	active site
223283015392	nudix motif; other site
223283015393	metal binding site [ion binding]; metal-binding site
223283015394	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
223283015395	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
223283015396	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
223283015397	Na binding site [ion binding]; other site
223283015398	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
223283015399	ThiC-associated domain; Region: ThiC-associated; pfam13667
223283015400	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
223283015401	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
223283015402	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
223283015403	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
223283015404	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
223283015405	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
223283015406	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
223283015407	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283015408	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
223283015409	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
223283015410	active site
223283015411	catalytic tetrad [active]
223283015412	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
223283015413	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
223283015414	putative ribose interaction site [chemical binding]; other site
223283015415	putative ADP binding site [chemical binding]; other site
223283015416	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
223283015417	active site
223283015418	nucleotide binding site [chemical binding]; other site
223283015419	HIGH motif; other site
223283015420	KMSKS motif; other site
223283015421	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
223283015422	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
223283015423	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
223283015424	Walker A/P-loop; other site
223283015425	ATP binding site [chemical binding]; other site
223283015426	Q-loop/lid; other site
223283015427	ABC transporter signature motif; other site
223283015428	Walker B; other site
223283015429	D-loop; other site
223283015430	H-loop/switch region; other site
223283015431	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
223283015432	active site
223283015433	ATP binding site [chemical binding]; other site
223283015434	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
223283015435	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283015436	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
223283015437	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
223283015438	Mig-14; Region: Mig-14; pfam07395
223283015439	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
223283015440	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
223283015441	putative ADP-binding pocket [chemical binding]; other site
223283015442	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283015443	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
223283015444	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
223283015445	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283015446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283015447	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283015448	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283015449	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283015450	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283015451	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283015452	C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647
223283015453	C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647
223283015454	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
223283015455	active site
223283015456	ATP binding site [chemical binding]; other site
223283015457	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
223283015458	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
223283015459	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
223283015460	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
223283015461	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
223283015462	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
223283015463	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
223283015464	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
223283015465	putative active site [active]
223283015466	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
223283015467	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
223283015468	putative active site [active]
223283015469	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
223283015470	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
223283015471	metal binding triad; other site
223283015472	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
223283015473	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
223283015474	metal binding triad; other site
223283015475	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
223283015476	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
223283015477	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
223283015478	dimer interface [polypeptide binding]; other site
223283015479	TPP-binding site [chemical binding]; other site
223283015480	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
223283015481	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
223283015482	E3 interaction surface; other site
223283015483	lipoyl attachment site [posttranslational modification]; other site
223283015484	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
223283015485	E3 interaction surface; other site
223283015486	lipoyl attachment site [posttranslational modification]; other site
223283015487	e3 binding domain; Region: E3_binding; pfam02817
223283015488	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
223283015489	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
223283015490	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
223283015491	ATP binding site [chemical binding]; other site
223283015492	Mg++ binding site [ion binding]; other site
223283015493	motif III; other site
223283015494	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283015495	nucleotide binding region [chemical binding]; other site
223283015496	ATP-binding site [chemical binding]; other site
223283015497	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
223283015498	putative RNA binding site [nucleotide binding]; other site
223283015499	HI0933-like protein; Region: HI0933_like; pfam03486
223283015500	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283015501	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
223283015502	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
223283015503	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
223283015504	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283015505	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283015506	substrate binding pocket [chemical binding]; other site
223283015507	membrane-bound complex binding site; other site
223283015508	hinge residues; other site
223283015509	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283015510	Coenzyme A binding pocket [chemical binding]; other site
223283015511	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
223283015512	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
223283015513	Response regulator receiver domain; Region: Response_reg; pfam00072
223283015514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283015515	active site
223283015516	phosphorylation site [posttranslational modification]
223283015517	intermolecular recognition site; other site
223283015518	dimerization interface [polypeptide binding]; other site
223283015519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283015520	PAS domain; Region: PAS_9; pfam13426
223283015521	putative active site [active]
223283015522	heme pocket [chemical binding]; other site
223283015523	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
223283015524	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283015525	metal binding site [ion binding]; metal-binding site
223283015526	active site
223283015527	I-site; other site
223283015528	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283015529	Alginate lyase; Region: Alginate_lyase2; pfam08787
223283015530	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
223283015531	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
223283015532	Na binding site [ion binding]; other site
223283015533	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
223283015534	Predicted transcriptional regulator [Transcription]; Region: COG3905
223283015535	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
223283015536	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
223283015537	Glutamate binding site [chemical binding]; other site
223283015538	NAD binding site [chemical binding]; other site
223283015539	catalytic residues [active]
223283015540	putative transposase OrfB; Reviewed; Region: PHA02517
223283015541	HTH-like domain; Region: HTH_21; pfam13276
223283015542	Integrase core domain; Region: rve; pfam00665
223283015543	Integrase core domain; Region: rve_2; pfam13333
223283015544	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283015545	Helix-turn-helix domain; Region: HTH_28; pfam13518
223283015546	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
223283015547	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
223283015548	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
223283015549	active site
223283015550	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
223283015551	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
223283015552	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
223283015553	TrkA-C domain; Region: TrkA_C; pfam02080
223283015554	Transporter associated domain; Region: CorC_HlyC; smart01091
223283015555	hypothetical protein; Provisional; Region: PRK11281
223283015556	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
223283015557	Mechanosensitive ion channel; Region: MS_channel; pfam00924
223283015558	Transcriptional regulators [Transcription]; Region: GntR; COG1802
223283015559	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283015560	DNA-binding site [nucleotide binding]; DNA binding site
223283015561	FCD domain; Region: FCD; pfam07729
223283015562	Uncharacterized conserved protein [Function unknown]; Region: COG0397
223283015563	hypothetical protein; Validated; Region: PRK00029
223283015564	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
223283015565	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
223283015566	putative binding surface; other site
223283015567	active site
223283015568	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
223283015569	putative binding surface; other site
223283015570	active site
223283015571	Hpt domain; Region: Hpt; pfam01627
223283015572	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
223283015573	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
223283015574	putative binding surface; other site
223283015575	active site
223283015576	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
223283015577	putative binding surface; other site
223283015578	active site
223283015579	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
223283015580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283015581	ATP binding site [chemical binding]; other site
223283015582	Mg2+ binding site [ion binding]; other site
223283015583	G-X-G motif; other site
223283015584	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
223283015585	Response regulator receiver domain; Region: Response_reg; pfam00072
223283015586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283015587	active site
223283015588	phosphorylation site [posttranslational modification]
223283015589	intermolecular recognition site; other site
223283015590	dimerization interface [polypeptide binding]; other site
223283015591	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
223283015592	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283015593	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283015594	dimer interface [polypeptide binding]; other site
223283015595	putative CheW interface [polypeptide binding]; other site
223283015596	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
223283015597	Response regulator receiver domain; Region: Response_reg; pfam00072
223283015598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283015599	active site
223283015600	phosphorylation site [posttranslational modification]
223283015601	intermolecular recognition site; other site
223283015602	dimerization interface [polypeptide binding]; other site
223283015603	Response regulator receiver domain; Region: Response_reg; pfam00072
223283015604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283015605	active site
223283015606	phosphorylation site [posttranslational modification]
223283015607	intermolecular recognition site; other site
223283015608	dimerization interface [polypeptide binding]; other site
223283015609	glutathione synthetase; Provisional; Region: PRK05246
223283015610	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
223283015611	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
223283015612	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
223283015613	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
223283015614	hypothetical protein; Validated; Region: PRK00228
223283015615	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
223283015616	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
223283015617	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
223283015618	active site
223283015619	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
223283015620	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
223283015621	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
223283015622	dihydroorotase; Validated; Region: pyrC; PRK09357
223283015623	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
223283015624	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
223283015625	active site
223283015626	TM2 domain; Region: TM2; cl00984
223283015627	TM2 domain; Region: TM2; cl00984
223283015628	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
223283015629	NlpC/P60 family; Region: NLPC_P60; pfam00877
223283015630	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
223283015631	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
223283015632	Walker A motif; other site
223283015633	ATP binding site [chemical binding]; other site
223283015634	Walker B motif; other site
223283015635	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
223283015636	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
223283015637	catalytic residue [active]
223283015638	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
223283015639	pyrroline-5-carboxylate reductase; Region: PLN02688
223283015640	YGGT family; Region: YGGT; pfam02325
223283015641	YGGT family; Region: YGGT; pfam02325
223283015642	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
223283015643	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
223283015644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283015645	S-adenosylmethionine binding site [chemical binding]; other site
223283015646	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
223283015647	active site
223283015648	dimerization interface [polypeptide binding]; other site
223283015649	HemN family oxidoreductase; Provisional; Region: PRK05660
223283015650	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283015651	FeS/SAM binding site; other site
223283015652	HemN C-terminal domain; Region: HemN_C; pfam06969
223283015653	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
223283015654	Protein of unknown function (DUF2875); Region: DUF2875; pfam11394
223283015655	Protein of unknown function (DUF3274); Region: DUF3274; pfam11678
223283015656	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
223283015657	aminotransferase; Validated; Region: PRK08175
223283015658	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283015659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283015660	homodimer interface [polypeptide binding]; other site
223283015661	catalytic residue [active]
223283015662	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
223283015663	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
223283015664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
223283015665	putative aldolase; Validated; Region: PRK08130
223283015666	intersubunit interface [polypeptide binding]; other site
223283015667	active site
223283015668	Zn2+ binding site [ion binding]; other site
223283015669	fructuronate transporter; Provisional; Region: PRK10034; cl15264
223283015670	fructuronate transporter; Provisional; Region: PRK10034; cl15264
223283015671	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
223283015672	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283015673	Transposase; Region: HTH_Tnp_1; cl17663
223283015674	putative transposase OrfB; Reviewed; Region: PHA02517
223283015675	HTH-like domain; Region: HTH_21; pfam13276
223283015676	Integrase core domain; Region: rve; pfam00665
223283015677	Integrase core domain; Region: rve_2; pfam13333
223283015678	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
223283015679	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
223283015680	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
223283015681	homotetramer interface [polypeptide binding]; other site
223283015682	ligand binding site [chemical binding]; other site
223283015683	catalytic site [active]
223283015684	NAD binding site [chemical binding]; other site
223283015685	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
223283015686	FAD binding site [chemical binding]; other site
223283015687	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
223283015688	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
223283015689	ATP binding site [chemical binding]; other site
223283015690	Mg++ binding site [ion binding]; other site
223283015691	motif III; other site
223283015692	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283015693	nucleotide binding region [chemical binding]; other site
223283015694	ATP-binding site [chemical binding]; other site
223283015695	hypothetical protein; Provisional; Region: PRK03757
223283015696	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
223283015697	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
223283015698	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
223283015699	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283015700	inhibitor-cofactor binding pocket; inhibition site
223283015701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283015702	catalytic residue [active]
223283015703	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
223283015704	RNA methyltransferase, RsmE family; Region: TIGR00046
223283015705	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
223283015706	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
223283015707	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283015708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283015709	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
223283015710	putative dimerization interface [polypeptide binding]; other site
223283015711	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
223283015712	Malonate transporter MadL subunit; Region: MadL; cl04273
223283015713	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
223283015714	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
223283015715	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
223283015716	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
223283015717	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833
223283015718	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
223283015719	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
223283015720	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
223283015721	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
223283015722	PAAR motif; Region: PAAR_motif; pfam05488
223283015723	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
223283015724	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
223283015725	P-loop; other site
223283015726	Magnesium ion binding site [ion binding]; other site
223283015727	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
223283015728	Magnesium ion binding site [ion binding]; other site
223283015729	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
223283015730	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
223283015731	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
223283015732	putative acyl-acceptor binding pocket; other site
223283015733	Phosphopantetheine attachment site; Region: PP-binding; cl09936
223283015734	acyl carrier protein; Provisional; Region: PRK05350
223283015735	Predicted membrane protein [Function unknown]; Region: COG4648
223283015736	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
223283015737	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
223283015738	AMP binding site [chemical binding]; other site
223283015739	active site
223283015740	acyl-activating enzyme (AAE) consensus motif; other site
223283015741	CoA binding site [chemical binding]; other site
223283015742	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
223283015743	active site 2 [active]
223283015744	dimer interface [polypeptide binding]; other site
223283015745	active site 1 [active]
223283015746	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
223283015747	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
223283015748	Ligand binding site; other site
223283015749	Putative Catalytic site; other site
223283015750	DXD motif; other site
223283015751	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
223283015752	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
223283015753	putative acyl-acceptor binding pocket; other site
223283015754	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
223283015755	active sites [active]
223283015756	tetramer interface [polypeptide binding]; other site
223283015757	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
223283015758	active site
223283015759	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
223283015760	Predicted exporter [General function prediction only]; Region: COG4258
223283015761	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
223283015762	Methyltransferase domain; Region: Methyltransf_23; pfam13489
223283015763	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283015764	S-adenosylmethionine binding site [chemical binding]; other site
223283015765	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
223283015766	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
223283015767	dimer interface [polypeptide binding]; other site
223283015768	active site
223283015769	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
223283015770	putative active site 1 [active]
223283015771	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
223283015772	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
223283015773	NAD(P) binding site [chemical binding]; other site
223283015774	active site
223283015775	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
223283015776	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
223283015777	dimer interface [polypeptide binding]; other site
223283015778	active site
223283015779	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
223283015780	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283015781	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
223283015782	dimerization interface [polypeptide binding]; other site
223283015783	substrate binding pocket [chemical binding]; other site
223283015784	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283015785	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283015786	putative substrate translocation pore; other site
223283015787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283015788	AAA domain; Region: AAA_21; pfam13304
223283015789	Walker A/P-loop; other site
223283015790	ATP binding site [chemical binding]; other site
223283015791	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283015792	ABC transporter signature motif; other site
223283015793	Walker B; other site
223283015794	D-loop; other site
223283015795	H-loop/switch region; other site
223283015796	TIGR02646 family protein; Region: TIGR02646
223283015797	fructuronate transporter; Provisional; Region: PRK10034; cl15264
223283015798	GntP family permease; Region: GntP_permease; pfam02447
223283015799	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
223283015800	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
223283015801	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
223283015802	putative active site [active]
223283015803	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
223283015804	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
223283015805	active site
223283015806	putative substrate binding pocket [chemical binding]; other site
223283015807	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
223283015808	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
223283015809	substrate binding site [chemical binding]; other site
223283015810	active site
223283015811	amidase; Provisional; Region: PRK08137
223283015812	Amidase; Region: Amidase; cl11426
223283015813	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
223283015814	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
223283015815	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
223283015816	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
223283015817	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
223283015818	active site
223283015819	dimer interface [polypeptide binding]; other site
223283015820	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
223283015821	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
223283015822	active site
223283015823	FMN binding site [chemical binding]; other site
223283015824	substrate binding site [chemical binding]; other site
223283015825	3Fe-4S cluster binding site [ion binding]; other site
223283015826	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
223283015827	domain interface; other site
223283015828	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
223283015829	Sporulation related domain; Region: SPOR; pfam05036
223283015830	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
223283015831	active site
223283015832	dimer interface [polypeptide binding]; other site
223283015833	metal binding site [ion binding]; metal-binding site
223283015834	shikimate kinase; Reviewed; Region: aroK; PRK00131
223283015835	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
223283015836	ADP binding site [chemical binding]; other site
223283015837	magnesium binding site [ion binding]; other site
223283015838	putative shikimate binding site; other site
223283015839	AMIN domain; Region: AMIN; pfam11741
223283015840	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
223283015841	Secretin and TonB N terminus short domain; Region: STN; smart00965
223283015842	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
223283015843	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
223283015844	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
223283015845	Pilus assembly protein, PilP; Region: PilP; pfam04351
223283015846	Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167
223283015847	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
223283015848	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
223283015849	Competence protein A; Region: Competence_A; pfam11104
223283015850	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
223283015851	nucleotide binding site [chemical binding]; other site
223283015852	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
223283015853	Transglycosylase; Region: Transgly; pfam00912
223283015854	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
223283015855	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
223283015856	Malic enzyme, N-terminal domain; Region: malic; pfam00390
223283015857	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
223283015858	putative NAD(P) binding site [chemical binding]; other site
223283015859	Catalytic site; other site
223283015860	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
223283015861	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
223283015862	primosome assembly protein PriA; Validated; Region: PRK05580
223283015863	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283015864	ATP binding site [chemical binding]; other site
223283015865	putative Mg++ binding site [ion binding]; other site
223283015866	helicase superfamily c-terminal domain; Region: HELICc; smart00490
223283015867	ATP-binding site [chemical binding]; other site
223283015868	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
223283015869	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
223283015870	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
223283015871	active site
223283015872	HIGH motif; other site
223283015873	KMSK motif region; other site
223283015874	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
223283015875	tRNA binding surface [nucleotide binding]; other site
223283015876	anticodon binding site; other site
223283015877	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
223283015878	Sporulation related domain; Region: SPOR; pfam05036
223283015879	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
223283015880	active site
223283015881	HslU subunit interaction site [polypeptide binding]; other site
223283015882	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
223283015883	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283015884	Walker A motif; other site
223283015885	ATP binding site [chemical binding]; other site
223283015886	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
223283015887	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
223283015888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
223283015889	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
223283015890	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
223283015891	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
223283015892	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
223283015893	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283015894	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283015895	Bacterial transcriptional repressor; Region: TetR; pfam13972
223283015896	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
223283015897	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
223283015898	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650
223283015899	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
223283015900	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283015901	S-adenosylmethionine binding site [chemical binding]; other site
223283015902	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
223283015903	SCP-2 sterol transfer family; Region: SCP2; pfam02036
223283015904	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
223283015905	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
223283015906	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
223283015907	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
223283015908	metal binding site [ion binding]; metal-binding site
223283015909	twin arginine translocase protein A; Provisional; Region: tatA; PRK00442
223283015910	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
223283015911	sec-independent translocase; Provisional; Region: tatB; PRK00404
223283015912	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
223283015913	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
223283015914	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
223283015915	RNA methyltransferase, RsmE family; Region: TIGR00046
223283015916	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283015917	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283015918	dimerization interface [polypeptide binding]; other site
223283015919	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283015920	dimer interface [polypeptide binding]; other site
223283015921	putative CheW interface [polypeptide binding]; other site
223283015922	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283015923	dimerization interface [polypeptide binding]; other site
223283015924	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283015925	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283015926	dimer interface [polypeptide binding]; other site
223283015927	putative CheW interface [polypeptide binding]; other site
223283015928	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
223283015929	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
223283015930	Ligand binding site; other site
223283015931	DXD motif; other site
223283015932	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
223283015933	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
223283015934	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
223283015935	putative active site [active]
223283015936	dimerization interface [polypeptide binding]; other site
223283015937	putative tRNAtyr binding site [nucleotide binding]; other site
223283015938	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
223283015939	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
223283015940	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
223283015941	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
223283015942	homodimer interface [polypeptide binding]; other site
223283015943	active site pocket [active]
223283015944	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
223283015945	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
223283015946	fructose-1,6-bisphosphatase family protein; Region: PLN02628
223283015947	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
223283015948	AMP binding site [chemical binding]; other site
223283015949	metal binding site [ion binding]; metal-binding site
223283015950	active site
223283015951	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
223283015952	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
223283015953	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
223283015954	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
223283015955	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
223283015956	active site
223283015957	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
223283015958	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283015959	DNA-binding site [nucleotide binding]; DNA binding site
223283015960	UTRA domain; Region: UTRA; pfam07702
223283015961	HutD; Region: HutD; pfam05962
223283015962	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
223283015963	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
223283015964	RNA polymerase sigma factor; Provisional; Region: PRK12537
223283015965	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
223283015966	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
223283015967	DNA binding residues [nucleotide binding]
223283015968	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
223283015969	Anti-sigma-K factor rskA; Region: RskA; pfam10099
223283015970	serine O-acetyltransferase; Region: cysE; TIGR01172
223283015971	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
223283015972	trimer interface [polypeptide binding]; other site
223283015973	active site
223283015974	substrate binding site [chemical binding]; other site
223283015975	CoA binding site [chemical binding]; other site
223283015976	D-cysteine desulfhydrase; Validated; Region: PRK03910
223283015977	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
223283015978	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
223283015979	catalytic residue [active]
223283015980	cystine transporter subunit; Provisional; Region: PRK11260
223283015981	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283015982	substrate binding pocket [chemical binding]; other site
223283015983	membrane-bound complex binding site; other site
223283015984	hinge residues; other site
223283015985	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283015986	dimer interface [polypeptide binding]; other site
223283015987	conserved gate region; other site
223283015988	putative PBP binding loops; other site
223283015989	ABC-ATPase subunit interface; other site
223283015990	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
223283015991	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283015992	Walker A/P-loop; other site
223283015993	ATP binding site [chemical binding]; other site
223283015994	Q-loop/lid; other site
223283015995	ABC transporter signature motif; other site
223283015996	Walker B; other site
223283015997	D-loop; other site
223283015998	H-loop/switch region; other site
223283015999	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
223283016000	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
223283016001	active site
223283016002	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
223283016003	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
223283016004	Flavin binding site [chemical binding]; other site
223283016005	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
223283016006	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
223283016007	active site
223283016008	non-prolyl cis peptide bond; other site
223283016009	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
223283016010	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
223283016011	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
223283016012	Walker A/P-loop; other site
223283016013	ATP binding site [chemical binding]; other site
223283016014	Q-loop/lid; other site
223283016015	ABC transporter signature motif; other site
223283016016	Walker B; other site
223283016017	D-loop; other site
223283016018	H-loop/switch region; other site
223283016019	NIL domain; Region: NIL; pfam09383
223283016020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016021	dimer interface [polypeptide binding]; other site
223283016022	conserved gate region; other site
223283016023	ABC-ATPase subunit interface; other site
223283016024	Methyltransferase domain; Region: Methyltransf_23; pfam13489
223283016025	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283016026	S-adenosylmethionine binding site [chemical binding]; other site
223283016027	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
223283016028	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
223283016029	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
223283016030	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283016031	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
223283016032	HlyD family secretion protein; Region: HlyD_3; pfam13437
223283016033	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
223283016034	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
223283016035	NMT1-like family; Region: NMT1_2; pfam13379
223283016036	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
223283016037	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016038	dimer interface [polypeptide binding]; other site
223283016039	conserved gate region; other site
223283016040	putative PBP binding loops; other site
223283016041	ABC-ATPase subunit interface; other site
223283016042	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
223283016043	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
223283016044	Walker A/P-loop; other site
223283016045	ATP binding site [chemical binding]; other site
223283016046	Q-loop/lid; other site
223283016047	ABC transporter signature motif; other site
223283016048	Walker B; other site
223283016049	D-loop; other site
223283016050	H-loop/switch region; other site
223283016051	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
223283016052	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
223283016053	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
223283016054	active site
223283016055	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
223283016056	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
223283016057	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
223283016058	Autotransporter beta-domain; Region: Autotransporter; pfam03797
223283016059	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
223283016060	Sel1 repeat; Region: Sel1; cl02723
223283016061	EF-hand, calcium binding motif; Region: EFh; smart00054
223283016062	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
223283016063	EF-hand, calcium binding motif; Region: EFh; smart00054
223283016064	Ca2+ binding site [ion binding]; other site
223283016065	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
223283016066	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
223283016067	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
223283016068	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283016069	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016070	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283016071	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283016072	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283016073	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016074	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283016075	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016076	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283016077	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283016078	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016079	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283016080	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283016081	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283016082	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
223283016083	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
223283016084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283016085	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
223283016086	Walker A motif; other site
223283016087	ATP binding site [chemical binding]; other site
223283016088	Walker B motif; other site
223283016089	arginine finger; other site
223283016090	Serine hydrolase; Region: Ser_hydrolase; pfam06821
223283016091	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
223283016092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283016093	D-galactonate transporter; Region: 2A0114; TIGR00893
223283016094	putative substrate translocation pore; other site
223283016095	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
223283016096	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
223283016097	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
223283016098	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
223283016099	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714
223283016100	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
223283016101	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
223283016102	proline aminopeptidase P II; Provisional; Region: PRK10879
223283016103	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
223283016104	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
223283016105	active site
223283016106	hypothetical protein; Reviewed; Region: PRK02166
223283016107	TIGR02449 family protein; Region: TIGR02449
223283016108	Cell division protein ZapA; Region: ZapA; pfam05164
223283016109	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
223283016110	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
223283016111	Uncharacterized conserved protein [Function unknown]; Region: COG2947
223283016112	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
223283016113	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
223283016114	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
223283016115	NAD(P) binding site [chemical binding]; other site
223283016116	S-type Pyocin; Region: Pyocin_S; pfam06958
223283016117	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
223283016118	active site
223283016119	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
223283016120	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
223283016121	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
223283016122	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283016123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283016124	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
223283016125	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
223283016126	putative active site pocket [active]
223283016127	dimerization interface [polypeptide binding]; other site
223283016128	putative catalytic residue [active]
223283016129	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
223283016130	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
223283016131	catalytic loop [active]
223283016132	iron binding site [ion binding]; other site
223283016133	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
223283016134	FAD binding pocket [chemical binding]; other site
223283016135	FAD binding motif [chemical binding]; other site
223283016136	phosphate binding motif [ion binding]; other site
223283016137	beta-alpha-beta structure motif; other site
223283016138	NAD binding pocket [chemical binding]; other site
223283016139	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
223283016140	transcription termination factor Rho; Provisional; Region: rho; PRK09376
223283016141	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
223283016142	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
223283016143	RNA binding site [nucleotide binding]; other site
223283016144	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
223283016145	multimer interface [polypeptide binding]; other site
223283016146	Walker A motif; other site
223283016147	ATP binding site [chemical binding]; other site
223283016148	Walker B motif; other site
223283016149	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
223283016150	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
223283016151	catalytic residues [active]
223283016152	Transcriptional regulators [Transcription]; Region: FadR; COG2186
223283016153	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283016154	DNA-binding site [nucleotide binding]; DNA binding site
223283016155	FCD domain; Region: FCD; pfam07729
223283016156	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283016157	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283016158	substrate binding pocket [chemical binding]; other site
223283016159	membrane-bound complex binding site; other site
223283016160	hinge residues; other site
223283016161	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283016162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016163	dimer interface [polypeptide binding]; other site
223283016164	conserved gate region; other site
223283016165	putative PBP binding loops; other site
223283016166	ABC-ATPase subunit interface; other site
223283016167	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283016168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016169	dimer interface [polypeptide binding]; other site
223283016170	conserved gate region; other site
223283016171	putative PBP binding loops; other site
223283016172	ABC-ATPase subunit interface; other site
223283016173	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
223283016174	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283016175	Walker A/P-loop; other site
223283016176	ATP binding site [chemical binding]; other site
223283016177	Q-loop/lid; other site
223283016178	ABC transporter signature motif; other site
223283016179	Walker B; other site
223283016180	D-loop; other site
223283016181	H-loop/switch region; other site
223283016182	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
223283016183	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
223283016184	polyphosphate kinase; Provisional; Region: PRK05443
223283016185	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
223283016186	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
223283016187	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
223283016188	putative active site [active]
223283016189	catalytic site [active]
223283016190	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
223283016191	putative domain interface [polypeptide binding]; other site
223283016192	putative active site [active]
223283016193	catalytic site [active]
223283016194	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
223283016195	dimer interface [polypeptide binding]; other site
223283016196	active site
223283016197	aspartate-rich active site metal binding site; other site
223283016198	allosteric magnesium binding site [ion binding]; other site
223283016199	Schiff base residues; other site
223283016200	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
223283016201	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
223283016202	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
223283016203	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
223283016204	conserved cys residue [active]
223283016205	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
223283016206	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
223283016207	FeS/SAM binding site; other site
223283016208	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
223283016209	active site clefts [active]
223283016210	zinc binding site [ion binding]; other site
223283016211	dimer interface [polypeptide binding]; other site
223283016212	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
223283016213	Sulfate transporter family; Region: Sulfate_transp; pfam00916
223283016214	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
223283016215	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
223283016216	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
223283016217	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
223283016218	Cu(I) binding site [ion binding]; other site
223283016219	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
223283016220	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
223283016221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016222	conserved gate region; other site
223283016223	ABC-ATPase subunit interface; other site
223283016224	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
223283016225	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
223283016226	Walker A/P-loop; other site
223283016227	ATP binding site [chemical binding]; other site
223283016228	Q-loop/lid; other site
223283016229	ABC transporter signature motif; other site
223283016230	Walker B; other site
223283016231	D-loop; other site
223283016232	H-loop/switch region; other site
223283016233	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
223283016234	hydroperoxidase II; Provisional; Region: katE; PRK11249
223283016235	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
223283016236	tetramer interface [polypeptide binding]; other site
223283016237	heme binding pocket [chemical binding]; other site
223283016238	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
223283016239	domain interactions; other site
223283016240	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
223283016241	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
223283016242	dimer interface [polypeptide binding]; other site
223283016243	putative PBP binding regions; other site
223283016244	ABC-ATPase subunit  interface; other site
223283016245	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
223283016246	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
223283016247	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
223283016248	metal binding site 2 [ion binding]; metal-binding site
223283016249	putative DNA binding helix; other site
223283016250	metal binding site 1 [ion binding]; metal-binding site
223283016251	dimer interface [polypeptide binding]; other site
223283016252	structural Zn2+ binding site [ion binding]; other site
223283016253	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
223283016254	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
223283016255	metal binding site [ion binding]; metal-binding site
223283016256	BCCT family transporter; Region: BCCT; cl00569
223283016257	urocanate hydratase; Provisional; Region: PRK05414
223283016258	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
223283016259	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
223283016260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016261	dimer interface [polypeptide binding]; other site
223283016262	conserved gate region; other site
223283016263	putative PBP binding loops; other site
223283016264	ABC-ATPase subunit interface; other site
223283016265	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
223283016266	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
223283016267	Walker A/P-loop; other site
223283016268	ATP binding site [chemical binding]; other site
223283016269	Q-loop/lid; other site
223283016270	ABC transporter signature motif; other site
223283016271	Walker B; other site
223283016272	D-loop; other site
223283016273	H-loop/switch region; other site
223283016274	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
223283016275	active sites [active]
223283016276	tetramer interface [polypeptide binding]; other site
223283016277	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
223283016278	active sites [active]
223283016279	tetramer interface [polypeptide binding]; other site
223283016280	putative proline-specific permease; Provisional; Region: proY; PRK10580
223283016281	Spore germination protein; Region: Spore_permease; cl17796
223283016282	imidazolonepropionase; Validated; Region: PRK09356
223283016283	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
223283016284	active site
223283016285	N-formylglutamate amidohydrolase; Region: FGase; cl01522
223283016286	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
223283016287	Heavy-metal-associated domain; Region: HMA; pfam00403
223283016288	metal-binding site [ion binding]
223283016289	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
223283016290	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
223283016291	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
223283016292	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
223283016293	DNA binding residues [nucleotide binding]
223283016294	dimer interface [polypeptide binding]; other site
223283016295	putative metal binding site [ion binding]; other site
223283016296	thymidylate synthase; Provisional; Region: thyA; PRK13821
223283016297	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
223283016298	dimerization interface [polypeptide binding]; other site
223283016299	active site
223283016300	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
223283016301	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
223283016302	GAF domain; Region: GAF; pfam01590
223283016303	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
223283016304	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
223283016305	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
223283016306	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
223283016307	putative active site [active]
223283016308	Ap4A binding site [chemical binding]; other site
223283016309	nudix motif; other site
223283016310	putative metal binding site [ion binding]; other site
223283016311	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
223283016312	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283016313	motif II; other site
223283016314	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
223283016315	threonine dehydratase; Reviewed; Region: PRK09224
223283016316	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
223283016317	tetramer interface [polypeptide binding]; other site
223283016318	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283016319	catalytic residue [active]
223283016320	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
223283016321	putative Ile/Val binding site [chemical binding]; other site
223283016322	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
223283016323	putative Ile/Val binding site [chemical binding]; other site
223283016324	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
223283016325	tetramer (dimer of dimers) interface [polypeptide binding]; other site
223283016326	active site
223283016327	dimer interface [polypeptide binding]; other site
223283016328	SdiA-regulated; Region: SdiA-regulated; pfam06977
223283016329	SdiA-regulated; Region: SdiA-regulated; cd09971
223283016330	putative active site [active]
223283016331	SdiA-regulated; Region: SdiA-regulated; pfam06977
223283016332	SdiA-regulated; Region: SdiA-regulated; cd09971
223283016333	putative active site [active]
223283016334	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
223283016335	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
223283016336	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
223283016337	FAD binding domain; Region: FAD_binding_4; pfam01565
223283016338	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
223283016339	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
223283016340	ligand binding site [chemical binding]; other site
223283016341	NAD binding site [chemical binding]; other site
223283016342	tetramer interface [polypeptide binding]; other site
223283016343	catalytic site [active]
223283016344	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
223283016345	L-serine binding site [chemical binding]; other site
223283016346	ACT domain interface; other site
223283016347	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
223283016348	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
223283016349	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
223283016350	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
223283016351	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
223283016352	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
223283016353	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
223283016354	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
223283016355	active site
223283016356	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
223283016357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016358	dimer interface [polypeptide binding]; other site
223283016359	conserved gate region; other site
223283016360	putative PBP binding loops; other site
223283016361	ABC-ATPase subunit interface; other site
223283016362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016363	dimer interface [polypeptide binding]; other site
223283016364	conserved gate region; other site
223283016365	putative PBP binding loops; other site
223283016366	ABC-ATPase subunit interface; other site
223283016367	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
223283016368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283016369	Walker A/P-loop; other site
223283016370	ATP binding site [chemical binding]; other site
223283016371	Q-loop/lid; other site
223283016372	ABC transporter signature motif; other site
223283016373	Walker B; other site
223283016374	D-loop; other site
223283016375	H-loop/switch region; other site
223283016376	TOBE domain; Region: TOBE_2; pfam08402
223283016377	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283016378	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016379	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283016380	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283016381	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283016382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016383	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283016384	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
223283016385	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
223283016386	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
223283016387	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
223283016388	putative aminotransferase; Validated; Region: PRK07480
223283016389	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283016390	inhibitor-cofactor binding pocket; inhibition site
223283016391	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283016392	catalytic residue [active]
223283016393	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
223283016394	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
223283016395	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
223283016396	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
223283016397	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
223283016398	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
223283016399	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
223283016400	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
223283016401	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
223283016402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
223283016403	Walker A/P-loop; other site
223283016404	ATP binding site [chemical binding]; other site
223283016405	Q-loop/lid; other site
223283016406	ABC transporter signature motif; other site
223283016407	Walker B; other site
223283016408	D-loop; other site
223283016409	H-loop/switch region; other site
223283016410	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
223283016411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016412	dimer interface [polypeptide binding]; other site
223283016413	conserved gate region; other site
223283016414	putative PBP binding loops; other site
223283016415	ABC-ATPase subunit interface; other site
223283016416	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
223283016417	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283016418	substrate binding pocket [chemical binding]; other site
223283016419	membrane-bound complex binding site; other site
223283016420	hinge residues; other site
223283016421	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
223283016422	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
223283016423	dimer interface [polypeptide binding]; other site
223283016424	decamer (pentamer of dimers) interface [polypeptide binding]; other site
223283016425	catalytic triad [active]
223283016426	outer membrane porin, OprD family; Region: OprD; pfam03573
223283016427	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
223283016428	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283016429	substrate binding pocket [chemical binding]; other site
223283016430	membrane-bound complex binding site; other site
223283016431	hinge residues; other site
223283016432	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
223283016433	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
223283016434	Walker A/P-loop; other site
223283016435	ATP binding site [chemical binding]; other site
223283016436	Q-loop/lid; other site
223283016437	ABC transporter signature motif; other site
223283016438	Walker B; other site
223283016439	D-loop; other site
223283016440	H-loop/switch region; other site
223283016441	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
223283016442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016443	dimer interface [polypeptide binding]; other site
223283016444	conserved gate region; other site
223283016445	putative PBP binding loops; other site
223283016446	ABC-ATPase subunit interface; other site
223283016447	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
223283016448	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
223283016449	SecA binding site; other site
223283016450	Preprotein binding site; other site
223283016451	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
223283016452	GSH binding site [chemical binding]; other site
223283016453	catalytic residues [active]
223283016454	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
223283016455	active site residue [active]
223283016456	phosphoglyceromutase; Provisional; Region: PRK05434
223283016457	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
223283016458	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
223283016459	Peptidase family M23; Region: Peptidase_M23; pfam01551
223283016460	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
223283016461	C-terminal peptidase (prc); Region: prc; TIGR00225
223283016462	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
223283016463	protein binding site [polypeptide binding]; other site
223283016464	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
223283016465	Catalytic dyad [active]
223283016466	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
223283016467	NodB motif; other site
223283016468	putative active site [active]
223283016469	putative catalytic site [active]
223283016470	Zn binding site [ion binding]; other site
223283016471	Peptidase M60-like family; Region: M60-like; pfam13402
223283016472	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
223283016473	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
223283016474	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283016475	substrate binding pocket [chemical binding]; other site
223283016476	membrane-bound complex binding site; other site
223283016477	hinge residues; other site
223283016478	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
223283016479	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
223283016480	substrate binding site [chemical binding]; other site
223283016481	glutamase interaction surface [polypeptide binding]; other site
223283016482	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
223283016483	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
223283016484	catalytic residues [active]
223283016485	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
223283016486	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
223283016487	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
223283016488	putative active site [active]
223283016489	oxyanion strand; other site
223283016490	catalytic triad [active]
223283016491	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
223283016492	putative active site pocket [active]
223283016493	4-fold oligomerization interface [polypeptide binding]; other site
223283016494	metal binding residues [ion binding]; metal-binding site
223283016495	3-fold/trimer interface [polypeptide binding]; other site
223283016496	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
223283016497	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283016498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283016499	homodimer interface [polypeptide binding]; other site
223283016500	catalytic residue [active]
223283016501	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
223283016502	AsmA family; Region: AsmA; pfam05170
223283016503	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
223283016504	adenine DNA glycosylase; Provisional; Region: PRK10880
223283016505	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
223283016506	minor groove reading motif; other site
223283016507	helix-hairpin-helix signature motif; other site
223283016508	substrate binding pocket [chemical binding]; other site
223283016509	active site
223283016510	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
223283016511	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
223283016512	DNA binding and oxoG recognition site [nucleotide binding]
223283016513	oxidative damage protection protein; Provisional; Region: PRK05408
223283016514	integrase; Provisional; Region: PRK09692
223283016515	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
223283016516	active site
223283016517	Int/Topo IB signature motif; other site
223283016518	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
223283016519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283016520	PAS domain; Region: PAS_9; pfam13426
223283016521	putative active site [active]
223283016522	heme pocket [chemical binding]; other site
223283016523	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283016524	PAS domain; Region: PAS_9; pfam13426
223283016525	putative active site [active]
223283016526	heme pocket [chemical binding]; other site
223283016527	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
223283016528	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283016529	dimer interface [polypeptide binding]; other site
223283016530	putative CheW interface [polypeptide binding]; other site
223283016531	Tir chaperone protein (CesT) family; Region: CesT; cl08444
223283016532	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
223283016533	Spore germination protein; Region: Spore_permease; cl17796
223283016534	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
223283016535	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
223283016536	Walker A/P-loop; other site
223283016537	ATP binding site [chemical binding]; other site
223283016538	Q-loop/lid; other site
223283016539	ABC transporter signature motif; other site
223283016540	Walker B; other site
223283016541	D-loop; other site
223283016542	H-loop/switch region; other site
223283016543	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
223283016544	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
223283016545	substrate binding pocket [chemical binding]; other site
223283016546	membrane-bound complex binding site; other site
223283016547	hinge residues; other site
223283016548	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283016549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016550	dimer interface [polypeptide binding]; other site
223283016551	conserved gate region; other site
223283016552	putative PBP binding loops; other site
223283016553	ABC-ATPase subunit interface; other site
223283016554	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
223283016555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016556	dimer interface [polypeptide binding]; other site
223283016557	conserved gate region; other site
223283016558	putative PBP binding loops; other site
223283016559	ABC-ATPase subunit interface; other site
223283016560	Methyltransferase domain; Region: Methyltransf_32; pfam13679
223283016561	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
223283016562	HSP70 interaction site [polypeptide binding]; other site
223283016563	DNA-sulfur modification-associated; Region: DndB; pfam14072
223283016564	DGQHR domain; Region: DGQHR; TIGR03187
223283016565	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016566	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283016567	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283016568	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016569	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283016570	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283016571	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283016572	transposase/IS protein; Provisional; Region: PRK09183
223283016573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283016574	Walker A motif; other site
223283016575	ATP binding site [chemical binding]; other site
223283016576	Walker B motif; other site
223283016577	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283016578	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
223283016579	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
223283016580	Transcriptional regulators [Transcription]; Region: GntR; COG1802
223283016581	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283016582	DNA-binding site [nucleotide binding]; DNA binding site
223283016583	FCD domain; Region: FCD; pfam07729
223283016584	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
223283016585	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
223283016586	putative active site [active]
223283016587	hypothetical protein; Provisional; Region: PRK05463
223283016588	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
223283016589	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
223283016590	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
223283016591	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
223283016592	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
223283016593	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
223283016594	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
223283016595	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
223283016596	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
223283016597	carboxyltransferase (CT) interaction site; other site
223283016598	biotinylation site [posttranslational modification]; other site
223283016599	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
223283016600	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
223283016601	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
223283016602	catalytic core [active]
223283016603	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
223283016604	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
223283016605	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
223283016606	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283016607	Coenzyme A binding pocket [chemical binding]; other site
223283016608	outer membrane porin, OprD family; Region: OprD; pfam03573
223283016609	agmatine deiminase; Provisional; Region: PRK13551
223283016610	agmatine deiminase; Region: agmatine_aguA; TIGR03380
223283016611	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
223283016612	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
223283016613	putative active site; other site
223283016614	catalytic triad [active]
223283016615	putative dimer interface [polypeptide binding]; other site
223283016616	hypothetical protein; Provisional; Region: PRK06149
223283016617	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
223283016618	active site
223283016619	substrate binding site [chemical binding]; other site
223283016620	ATP binding site [chemical binding]; other site
223283016621	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
223283016622	inhibitor-cofactor binding pocket; inhibition site
223283016623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283016624	catalytic residue [active]
223283016625	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
223283016626	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
223283016627	NAD binding site [chemical binding]; other site
223283016628	substrate binding site [chemical binding]; other site
223283016629	homodimer interface [polypeptide binding]; other site
223283016630	active site
223283016631	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
223283016632	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
223283016633	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283016634	dimer interface [polypeptide binding]; other site
223283016635	phosphorylation site [posttranslational modification]
223283016636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283016637	ATP binding site [chemical binding]; other site
223283016638	G-X-G motif; other site
223283016639	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
223283016640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283016641	active site
223283016642	phosphorylation site [posttranslational modification]
223283016643	intermolecular recognition site; other site
223283016644	dimerization interface [polypeptide binding]; other site
223283016645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283016646	Walker A motif; other site
223283016647	ATP binding site [chemical binding]; other site
223283016648	Walker B motif; other site
223283016649	arginine finger; other site
223283016650	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
223283016651	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
223283016652	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
223283016653	active site
223283016654	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
223283016655	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
223283016656	dimer interface [polypeptide binding]; other site
223283016657	ADP-ribose binding site [chemical binding]; other site
223283016658	active site
223283016659	nudix motif; other site
223283016660	metal binding site [ion binding]; metal-binding site
223283016661	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
223283016662	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283016663	motif II; other site
223283016664	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
223283016665	BON domain; Region: BON; pfam04972
223283016666	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
223283016667	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283016668	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283016669	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
223283016670	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
223283016671	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
223283016672	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
223283016673	putative molybdopterin cofactor binding site [chemical binding]; other site
223283016674	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
223283016675	putative molybdopterin cofactor binding site; other site
223283016676	DEAD-like helicases superfamily; Region: DEXDc; smart00487
223283016677	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
223283016678	ATP binding site [chemical binding]; other site
223283016679	putative Mg++ binding site [ion binding]; other site
223283016680	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
223283016681	nucleotide binding region [chemical binding]; other site
223283016682	ATP-binding site [chemical binding]; other site
223283016683	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283016684	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016685	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283016686	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283016687	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283016688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016689	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283016690	EF-hand, calcium binding motif; Region: EFh; smart00054
223283016691	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
223283016692	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
223283016693	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
223283016694	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
223283016695	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
223283016696	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
223283016697	Catalytic domain of Protein Kinases; Region: PKc; cd00180
223283016698	active site
223283016699	ATP binding site [chemical binding]; other site
223283016700	substrate binding site [chemical binding]; other site
223283016701	activation loop (A-loop); other site
223283016702	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
223283016703	active site
223283016704	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
223283016705	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
223283016706	G1 box; other site
223283016707	GTP/Mg2+ binding site [chemical binding]; other site
223283016708	G2 box; other site
223283016709	Switch I region; other site
223283016710	G3 box; other site
223283016711	Switch II region; other site
223283016712	G4 box; other site
223283016713	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
223283016714	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
223283016715	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
223283016716	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
223283016717	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
223283016718	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
223283016719	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
223283016720	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
223283016721	phosphopeptide binding site; other site
223283016722	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
223283016723	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283016724	Walker A motif; other site
223283016725	ATP binding site [chemical binding]; other site
223283016726	Walker B motif; other site
223283016727	arginine finger; other site
223283016728	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
223283016729	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
223283016730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283016731	Walker A motif; other site
223283016732	ATP binding site [chemical binding]; other site
223283016733	Walker B motif; other site
223283016734	arginine finger; other site
223283016735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283016736	Walker A motif; other site
223283016737	ATP binding site [chemical binding]; other site
223283016738	Walker B motif; other site
223283016739	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
223283016740	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
223283016741	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
223283016742	Transposase domain (DUF772); Region: DUF772; pfam05598
223283016743	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283016744	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283016745	Uncharacterized conserved protein [Function unknown]; Region: COG4104
223283016746	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
223283016747	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
223283016748	Protein of unknown function (DUF877); Region: DUF877; pfam05943
223283016749	Protein of unknown function (DUF770); Region: DUF770; pfam05591
223283016750	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
223283016751	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
223283016752	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
223283016753	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
223283016754	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
223283016755	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
223283016756	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
223283016757	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
223283016758	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
223283016759	RHS Repeat; Region: RHS_repeat; cl11982
223283016760	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
223283016761	RHS Repeat; Region: RHS_repeat; pfam05593
223283016762	RHS Repeat; Region: RHS_repeat; pfam05593
223283016763	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
223283016764	RHS Repeat; Region: RHS_repeat; pfam05593
223283016765	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
223283016766	RHS Repeat; Region: RHS_repeat; pfam05593
223283016767	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
223283016768	RHS protein; Region: RHS; pfam03527
223283016769	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
223283016770	Transposase domain (DUF772); Region: DUF772; pfam05598
223283016771	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283016772	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283016773	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283016774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016775	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283016776	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283016777	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283016778	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016779	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283016780	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283016781	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283016782	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283016783	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283016784	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283016785	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
223283016786	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
223283016787	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
223283016788	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
223283016789	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
223283016790	hydrolase; Region: PLN02811
223283016791	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
223283016792	motif II; other site
223283016793	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
223283016794	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
223283016795	active site
223283016796	catalytic tetrad [active]
223283016797	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
223283016798	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283016799	DNA-binding site [nucleotide binding]; DNA binding site
223283016800	FCD domain; Region: FCD; pfam07729
223283016801	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
223283016802	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
223283016803	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
223283016804	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
223283016805	AMP binding site [chemical binding]; other site
223283016806	acyl-activating enzyme (AAE) consensus motif; other site
223283016807	thioester reductase domain; Region: Thioester-redct; TIGR01746
223283016808	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
223283016809	putative NAD(P) binding site [chemical binding]; other site
223283016810	active site
223283016811	putative substrate binding site [chemical binding]; other site
223283016812	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
223283016813	putative hydrophobic ligand binding site [chemical binding]; other site
223283016814	protein interface [polypeptide binding]; other site
223283016815	gate; other site
223283016816	potential protein location (hypothetical protein PSPTO_5459 [Pseudomonas syringae pv. tomato str. DC3000]) that overlaps RNA (16S ribosomal RNA)
223283016817	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
223283016818	CoA-transferase family III; Region: CoA_transf_3; pfam02515
223283016819	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
223283016820	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
223283016821	FAD binding site [chemical binding]; other site
223283016822	substrate binding pocket [chemical binding]; other site
223283016823	catalytic base [active]
223283016824	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
223283016825	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283016826	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
223283016827	dimerization interface [polypeptide binding]; other site
223283016828	substrate binding pocket [chemical binding]; other site
223283016829	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
223283016830	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
223283016831	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
223283016832	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
223283016833	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
223283016834	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
223283016835	conserverd hypothetical protein; Region: TIGR02448
223283016836	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
223283016837	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
223283016838	Cell division protein FtsL; Region: FtsL; cl11433
223283016839	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
223283016840	IHF dimer interface [polypeptide binding]; other site
223283016841	IHF - DNA interface [nucleotide binding]; other site
223283016842	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
223283016843	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
223283016844	Rubredoxin [Energy production and conversion]; Region: COG1773
223283016845	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
223283016846	iron binding site [ion binding]; other site
223283016847	Chorismate lyase; Region: Chor_lyase; cl01230
223283016848	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
223283016849	UbiA prenyltransferase family; Region: UbiA; pfam01040
223283016850	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
223283016851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283016852	active site
223283016853	phosphorylation site [posttranslational modification]
223283016854	intermolecular recognition site; other site
223283016855	dimerization interface [polypeptide binding]; other site
223283016856	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
223283016857	DNA binding site [nucleotide binding]
223283016858	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
223283016859	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
223283016860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
223283016861	putative active site [active]
223283016862	heme pocket [chemical binding]; other site
223283016863	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283016864	dimer interface [polypeptide binding]; other site
223283016865	phosphorylation site [posttranslational modification]
223283016866	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283016867	ATP binding site [chemical binding]; other site
223283016868	Mg2+ binding site [ion binding]; other site
223283016869	G-X-G motif; other site
223283016870	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
223283016871	Domain of unknown function DUF21; Region: DUF21; pfam01595
223283016872	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
223283016873	Transporter associated domain; Region: CorC_HlyC; smart01091
223283016874	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
223283016875	Peptidase family M23; Region: Peptidase_M23; pfam01551
223283016876	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
223283016877	Response regulator receiver domain; Region: Response_reg; pfam00072
223283016878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283016879	active site
223283016880	phosphorylation site [posttranslational modification]
223283016881	intermolecular recognition site; other site
223283016882	dimerization interface [polypeptide binding]; other site
223283016883	transcriptional regulator PhoU; Provisional; Region: PRK11115
223283016884	PhoU domain; Region: PhoU; pfam01895
223283016885	PhoU domain; Region: PhoU; pfam01895
223283016886	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
223283016887	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
223283016888	Walker A/P-loop; other site
223283016889	ATP binding site [chemical binding]; other site
223283016890	Q-loop/lid; other site
223283016891	ABC transporter signature motif; other site
223283016892	Walker B; other site
223283016893	D-loop; other site
223283016894	H-loop/switch region; other site
223283016895	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
223283016896	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
223283016897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016898	dimer interface [polypeptide binding]; other site
223283016899	conserved gate region; other site
223283016900	putative PBP binding loops; other site
223283016901	ABC-ATPase subunit interface; other site
223283016902	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
223283016903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283016904	putative PBP binding loops; other site
223283016905	ABC-ATPase subunit interface; other site
223283016906	PBP superfamily domain; Region: PBP_like_2; cl17296
223283016907	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
223283016908	metabolite-proton symporter; Region: 2A0106; TIGR00883
223283016909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283016910	putative substrate translocation pore; other site
223283016911	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
223283016912	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
223283016913	active site
223283016914	phosphate binding residues; other site
223283016915	catalytic residues [active]
223283016916	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
223283016917	Predicted membrane protein [Function unknown]; Region: COG2261
223283016918	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
223283016919	ATP-grasp domain; Region: ATP-grasp; pfam02222
223283016920	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
223283016921	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
223283016922	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
223283016923	active site
223283016924	cell density-dependent motility repressor; Provisional; Region: PRK10082
223283016925	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283016926	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
223283016927	dimerization interface [polypeptide binding]; other site
223283016928	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
223283016929	Aspartase; Region: Aspartase; cd01357
223283016930	active sites [active]
223283016931	tetramer interface [polypeptide binding]; other site
223283016932	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
223283016933	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
223283016934	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
223283016935	active site
223283016936	homodimer interface [polypeptide binding]; other site
223283016937	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
223283016938	Sulphur transport; Region: Sulf_transp; pfam04143
223283016939	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
223283016940	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283016941	DNA-binding site [nucleotide binding]; DNA binding site
223283016942	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
223283016943	pyridoxal 5'-phosphate binding site [chemical binding]; other site
223283016944	homodimer interface [polypeptide binding]; other site
223283016945	catalytic residue [active]
223283016946	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
223283016947	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
223283016948	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
223283016949	Coenzyme A binding pocket [chemical binding]; other site
223283016950	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
223283016951	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
223283016952	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283016953	Transposase; Region: HTH_Tnp_1; cl17663
223283016954	putative transposase OrfB; Reviewed; Region: PHA02517
223283016955	HTH-like domain; Region: HTH_21; pfam13276
223283016956	Integrase core domain; Region: rve; pfam00665
223283016957	Integrase core domain; Region: rve_2; pfam13333
223283016958	pyruvate carboxylase subunit B; Validated; Region: PRK09282
223283016959	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
223283016960	active site
223283016961	catalytic residues [active]
223283016962	metal binding site [ion binding]; metal-binding site
223283016963	homodimer binding site [polypeptide binding]; other site
223283016964	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
223283016965	carboxyltransferase (CT) interaction site; other site
223283016966	biotinylation site [posttranslational modification]; other site
223283016967	pyruvate carboxylase subunit A; Validated; Region: PRK07178
223283016968	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
223283016969	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
223283016970	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
223283016971	Transcriptional regulator [Transcription]; Region: LysR; COG0583
223283016972	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
223283016973	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
223283016974	putative dimerization interface [polypeptide binding]; other site
223283016975	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
223283016976	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
223283016977	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
223283016978	putative active site [active]
223283016979	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
223283016980	Part of AAA domain; Region: AAA_19; pfam13245
223283016981	Family description; Region: UvrD_C_2; pfam13538
223283016982	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
223283016983	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
223283016984	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
223283016985	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
223283016986	pyridoxamine kinase; Validated; Region: PRK05756
223283016987	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
223283016988	pyridoxal binding site [chemical binding]; other site
223283016989	dimer interface [polypeptide binding]; other site
223283016990	ATP binding site [chemical binding]; other site
223283016991	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
223283016992	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
223283016993	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
223283016994	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
223283016995	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
223283016996	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
223283016997	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
223283016998	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
223283016999	AMIN domain; Region: AMIN; pfam11741
223283017000	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
223283017001	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
223283017002	active site
223283017003	metal binding site [ion binding]; metal-binding site
223283017004	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
223283017005	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
223283017006	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
223283017007	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
223283017008	putative active site [active]
223283017009	catalytic site [active]
223283017010	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
223283017011	putative active site [active]
223283017012	catalytic site [active]
223283017013	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
223283017014	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
223283017015	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
223283017016	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
223283017017	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
223283017018	HflC protein; Region: hflC; TIGR01932
223283017019	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
223283017020	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
223283017021	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
223283017022	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
223283017023	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
223283017024	Putative methyltransferase; Region: Methyltransf_20; pfam12147
223283017025	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
223283017026	active site
223283017027	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
223283017028	active site
223283017029	catalytic residues [active]
223283017030	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
223283017031	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
223283017032	putative acyl-acceptor binding pocket; other site
223283017033	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
223283017034	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
223283017035	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
223283017036	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
223283017037	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283017038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283017039	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283017040	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283017041	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283017042	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283017043	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283017044	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
223283017045	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
223283017046	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
223283017047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
223283017048	active site
223283017049	phosphorylation site [posttranslational modification]
223283017050	intermolecular recognition site; other site
223283017051	dimerization interface [polypeptide binding]; other site
223283017052	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
223283017053	dimerization interface [polypeptide binding]; other site
223283017054	DNA binding residues [nucleotide binding]
223283017055	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283017056	dimer interface [polypeptide binding]; other site
223283017057	phosphorylation site [posttranslational modification]
223283017058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283017059	ATP binding site [chemical binding]; other site
223283017060	Mg2+ binding site [ion binding]; other site
223283017061	G-X-G motif; other site
223283017062	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
223283017063	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
223283017064	Walker A/P-loop; other site
223283017065	ATP binding site [chemical binding]; other site
223283017066	Q-loop/lid; other site
223283017067	ABC transporter signature motif; other site
223283017068	Walker B; other site
223283017069	D-loop; other site
223283017070	H-loop/switch region; other site
223283017071	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
223283017072	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
223283017073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283017074	dimer interface [polypeptide binding]; other site
223283017075	conserved gate region; other site
223283017076	putative PBP binding loops; other site
223283017077	ABC-ATPase subunit interface; other site
223283017078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
223283017079	dimer interface [polypeptide binding]; other site
223283017080	conserved gate region; other site
223283017081	putative PBP binding loops; other site
223283017082	ABC-ATPase subunit interface; other site
223283017083	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283017084	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283017085	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283017086	dimerization interface [polypeptide binding]; other site
223283017087	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283017088	dimer interface [polypeptide binding]; other site
223283017089	putative CheW interface [polypeptide binding]; other site
223283017090	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283017091	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283017092	dimerization interface [polypeptide binding]; other site
223283017093	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283017094	dimer interface [polypeptide binding]; other site
223283017095	putative CheW interface [polypeptide binding]; other site
223283017096	Transposase domain (DUF772); Region: DUF772; pfam05598
223283017097	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283017098	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283017099	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
223283017100	ligand-binding site [chemical binding]; other site
223283017101	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
223283017102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283017103	S-adenosylmethionine binding site [chemical binding]; other site
223283017104	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
223283017105	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
223283017106	N-terminal plug; other site
223283017107	ligand-binding site [chemical binding]; other site
223283017108	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
223283017109	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
223283017110	Walker A/P-loop; other site
223283017111	ATP binding site [chemical binding]; other site
223283017112	Q-loop/lid; other site
223283017113	ABC transporter signature motif; other site
223283017114	Walker B; other site
223283017115	D-loop; other site
223283017116	H-loop/switch region; other site
223283017117	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
223283017118	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
223283017119	putative ligand binding residues [chemical binding]; other site
223283017120	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
223283017121	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
223283017122	ABC-ATPase subunit  interface; other site
223283017123	dimer interface [polypeptide binding]; other site
223283017124	putative PBP binding regions; other site
223283017125	Transposase domain (DUF772); Region: DUF772; pfam05598
223283017126	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283017127	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283017128	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
223283017129	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
223283017130	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
223283017131	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
223283017132	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
223283017133	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
223283017134	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
223283017135	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
223283017136	dimerization interface [polypeptide binding]; other site
223283017137	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
223283017138	dimer interface [polypeptide binding]; other site
223283017139	putative CheW interface [polypeptide binding]; other site
223283017140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
223283017141	Transposase; Region: DEDD_Tnp_IS110; pfam01548
223283017142	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
223283017143	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
223283017144	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
223283017145	dimer interface [polypeptide binding]; other site
223283017146	phosphorylation site [posttranslational modification]
223283017147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
223283017148	ATP binding site [chemical binding]; other site
223283017149	Mg2+ binding site [ion binding]; other site
223283017150	G-X-G motif; other site
223283017151	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283017152	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283017153	DNA-binding interface [nucleotide binding]; DNA binding site
223283017154	Integrase core domain; Region: rve; pfam00665
223283017155	Integrase core domain; Region: rve_3; cl15866
223283017156	transposase/IS protein; Provisional; Region: PRK09183
223283017157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283017158	Walker A motif; other site
223283017159	ATP binding site [chemical binding]; other site
223283017160	Walker B motif; other site
223283017161	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283017162	S-adenosylmethionine binding site [chemical binding]; other site
223283017163	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
223283017164	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
223283017165	DNA binding residues [nucleotide binding]
223283017166	dimer interface [polypeptide binding]; other site
223283017167	putative metal binding site [ion binding]; other site
223283017168	Sodium Bile acid symporter family; Region: SBF; cl17470
223283017169	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
223283017170	Transposase; Region: HTH_Tnp_1; pfam01527
223283017171	Transposase domain (DUF772); Region: DUF772; pfam05598
223283017172	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
223283017173	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
223283017174	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
223283017175	catalytic core [active]
223283017176	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
223283017177	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
223283017178	Sulfatase; Region: Sulfatase; pfam00884
223283017179	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
223283017180	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
223283017181	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
223283017182	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
223283017183	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
223283017184	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
223283017185	putative NAD(P) binding site [chemical binding]; other site
223283017186	active site
223283017187	putative substrate binding site [chemical binding]; other site
223283017188	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
223283017189	Ligand binding site; other site
223283017190	Putative Catalytic site; other site
223283017191	DXD motif; other site
223283017192	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
223283017193	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
223283017194	SdiA-regulated; Region: SdiA-regulated; pfam06977
223283017195	SdiA-regulated; Region: SdiA-regulated; cd09971
223283017196	putative active site [active]
223283017197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283017198	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
223283017199	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
223283017200	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
223283017201	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
223283017202	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
223283017203	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
223283017204	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
223283017205	catalytic residues [active]
223283017206	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
223283017207	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
223283017208	glutaminase active site [active]
223283017209	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
223283017210	dimer interface [polypeptide binding]; other site
223283017211	active site
223283017212	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
223283017213	dimer interface [polypeptide binding]; other site
223283017214	active site
223283017215	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
223283017216	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
223283017217	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
223283017218	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
223283017219	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
223283017220	Substrate binding site; other site
223283017221	Mg++ binding site; other site
223283017222	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
223283017223	active site
223283017224	substrate binding site [chemical binding]; other site
223283017225	CoA binding site [chemical binding]; other site
223283017226	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
223283017227	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
223283017228	gamma subunit interface [polypeptide binding]; other site
223283017229	epsilon subunit interface [polypeptide binding]; other site
223283017230	LBP interface [polypeptide binding]; other site
223283017231	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
223283017232	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
223283017233	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
223283017234	alpha subunit interaction interface [polypeptide binding]; other site
223283017235	Walker A motif; other site
223283017236	ATP binding site [chemical binding]; other site
223283017237	Walker B motif; other site
223283017238	inhibitor binding site; inhibition site
223283017239	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
223283017240	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
223283017241	core domain interface [polypeptide binding]; other site
223283017242	delta subunit interface [polypeptide binding]; other site
223283017243	epsilon subunit interface [polypeptide binding]; other site
223283017244	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
223283017245	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
223283017246	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
223283017247	beta subunit interaction interface [polypeptide binding]; other site
223283017248	Walker A motif; other site
223283017249	ATP binding site [chemical binding]; other site
223283017250	Walker B motif; other site
223283017251	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
223283017252	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
223283017253	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
223283017254	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
223283017255	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
223283017256	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
223283017257	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
223283017258	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
223283017259	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
223283017260	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
223283017261	ParB-like nuclease domain; Region: ParBc; pfam02195
223283017262	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
223283017263	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
223283017264	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
223283017265	Magnesium ion binding site [ion binding]; other site
223283017266	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
223283017267	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
223283017268	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
223283017269	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
223283017270	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
223283017271	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
223283017272	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
223283017273	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
223283017274	trmE is a tRNA modification GTPase; Region: trmE; cd04164
223283017275	G1 box; other site
223283017276	GTP/Mg2+ binding site [chemical binding]; other site
223283017277	Switch I region; other site
223283017278	G2 box; other site
223283017279	Switch II region; other site
223283017280	G3 box; other site
223283017281	G4 box; other site
223283017282	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
223283017283	membrane protein insertase; Provisional; Region: PRK01318
223283017284	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
223283017285	hypothetical protein; Provisional; Region: PRK14371
223283017286	ribonuclease P; Reviewed; Region: rnpA; PRK00396
223283017287	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
223283017288	Replicase family; Region: Replicase; pfam03090
223283017289	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
223283017290	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
223283017291	Putative transposase; Region: Y2_Tnp; pfam04986
223283017292	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
223283017293	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
223283017294	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
223283017295	PilM; Region: PilM; pfam07419
223283017296	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
223283017297	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
223283017298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283017299	putative substrate translocation pore; other site
223283017300	Major Facilitator Superfamily; Region: MFS_1; pfam07690
223283017301	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
223283017302	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
223283017303	S-adenosylmethionine binding site [chemical binding]; other site
223283017304	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
223283017305	oligomeric interface; other site
223283017306	putative active site [active]
223283017307	homodimer interface [polypeptide binding]; other site
223283017308	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
223283017309	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
223283017310	Magnesium ion binding site [ion binding]; other site
223283017311	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
223283017312	multiple promoter invertase; Provisional; Region: mpi; PRK13413
223283017313	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
223283017314	catalytic residues [active]
223283017315	catalytic nucleophile [active]
223283017316	Phage-related protein [Function unknown]; Region: COG4679
223283017317	Helix-turn-helix domain; Region: HTH_37; pfam13744
223283017318	non-specific DNA binding site [nucleotide binding]; other site
223283017319	salt bridge; other site
223283017320	sequence-specific DNA binding site [nucleotide binding]; other site
223283017321	Domain of unknown function (DUF932); Region: DUF932; pfam06067
223283017322	DNA polymerase III subunit delta'; Validated; Region: PRK08058
223283017323	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
223283017324	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
223283017325	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
223283017326	transposase/IS protein; Provisional; Region: PRK09183
223283017327	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
223283017328	Walker A motif; other site
223283017329	ATP binding site [chemical binding]; other site
223283017330	Walker B motif; other site
223283017331	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283017332	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283017333	DNA-binding interface [nucleotide binding]; DNA binding site
223283017334	Integrase core domain; Region: rve; pfam00665
223283017335	Integrase core domain; Region: rve_3; cl15866
223283017336	Predicted dehydrogenase [General function prediction only]; Region: COG0579
223283017337	hydroxyglutarate oxidase; Provisional; Region: PRK11728
223283017338	metabolite-proton symporter; Region: 2A0106; TIGR00883
223283017339	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283017340	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
223283017341	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283017342	non-specific DNA binding site [nucleotide binding]; other site
223283017343	salt bridge; other site
223283017344	sequence-specific DNA binding site [nucleotide binding]; other site
223283017345	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), AnFA1; Region: NGN_SP_AnfA1; cd09894
223283017346	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
223283017347	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283017348	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283017349	catalytic residue [active]
223283017350	plasmid transfer ATPase TraJ; Region: plasmid_TraJ; TIGR02525
223283017351	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
223283017352	ATP binding site [chemical binding]; other site
223283017353	Walker B motif; other site
223283017354	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
223283017355	PLD-like domain; Region: PLDc_2; pfam13091
223283017356	putative active site [active]
223283017357	catalytic site [active]
223283017358	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
223283017359	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
223283017360	active site
223283017361	metal binding site [ion binding]; metal-binding site
223283017362	interdomain interaction site; other site
223283017363	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
223283017364	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
223283017365	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
223283017366	AAA-like domain; Region: AAA_10; pfam12846
223283017367	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
223283017368	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
223283017369	putative active site [active]
223283017370	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
223283017371	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
223283017372	catalytic residues [active]
223283017373	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
223283017374	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
223283017375	Transcriptional regulators [Transcription]; Region: GntR; COG1802
223283017376	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283017377	DNA-binding site [nucleotide binding]; DNA binding site
223283017378	Replicase family; Region: Replicase; pfam03090
223283017379	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
223283017380	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
223283017381	Catalytic site [active]
223283017382	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
223283017383	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
223283017384	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283017385	active site
223283017386	catalytic residues [active]
223283017387	DNA binding site [nucleotide binding]
223283017388	Int/Topo IB signature motif; other site
223283017389	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
223283017390	active site
223283017391	catalytic residues [active]
223283017392	DNA binding site [nucleotide binding]
223283017393	Int/Topo IB signature motif; other site
223283017394	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
223283017395	ParB-like nuclease domain; Region: ParBc; pfam02195
223283017396	KorB domain; Region: KorB; pfam08535
223283017397	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
223283017398	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
223283017399	P-loop; other site
223283017400	Magnesium ion binding site [ion binding]; other site
223283017401	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
223283017402	Magnesium ion binding site [ion binding]; other site
223283017403	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
223283017404	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
223283017405	multiple promoter invertase; Provisional; Region: mpi; PRK13413
223283017406	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
223283017407	catalytic residues [active]
223283017408	catalytic nucleophile [active]
223283017409	Presynaptic Site I dimer interface [polypeptide binding]; other site
223283017410	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
223283017411	Synaptic Flat tetramer interface [polypeptide binding]; other site
223283017412	Synaptic Site I dimer interface [polypeptide binding]; other site
223283017413	DNA binding site [nucleotide binding]
223283017414	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283017415	DNA-binding interface [nucleotide binding]; DNA binding site
223283017416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
223283017417	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
223283017418	DNA-binding interface [nucleotide binding]; DNA binding site
223283017419	Integrase core domain; Region: rve; pfam00665
223283017420	Integrase core domain; Region: rve_3; cl15866
223283017421	ParA-like protein; Provisional; Region: PHA02518
223283017422	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
223283017423	P-loop; other site
223283017424	Magnesium ion binding site [ion binding]; other site
223283017425	ParG; Region: ParG; pfam09274
223283017426	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
223283017427	NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129
223283017428	multiple promoter invertase; Provisional; Region: mpi; PRK13413
223283017429	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
223283017430	catalytic residues [active]
223283017431	catalytic nucleophile [active]
223283017432	Domain of unknown function (DUF932); Region: DUF932; pfam06067
223283017433	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
223283017434	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
223283017435	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
223283017436	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
223283017437	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
223283017438	active site
223283017439	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
223283017440	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
223283017441	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
223283017442	active site
223283017443	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
223283017444	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
223283017445	metal binding site [ion binding]; metal-binding site
223283017446	active site
223283017447	I-site; other site
223283017448	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
223283017449	Transcriptional regulators [Transcription]; Region: FadR; COG2186
223283017450	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283017451	DNA-binding site [nucleotide binding]; DNA binding site
223283017452	FCD domain; Region: FCD; pfam07729
223283017453	hydroxyglutarate oxidase; Provisional; Region: PRK11728
223283017454	Predicted dehydrogenase [General function prediction only]; Region: COG0579
223283017455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
223283017456	metabolite-proton symporter; Region: 2A0106; TIGR00883
223283017457	putative substrate translocation pore; other site
223283017458	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
223283017459	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
223283017460	non-specific DNA binding site [nucleotide binding]; other site
223283017461	salt bridge; other site
223283017462	sequence-specific DNA binding site [nucleotide binding]; other site
223283017463	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), AnFA1; Region: NGN_SP_AnfA1; cd09894
223283017464	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
223283017465	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
223283017466	N-acetyl-D-glucosamine binding site [chemical binding]; other site
223283017467	catalytic residue [active]
223283017468	plasmid transfer ATPase TraJ; Region: plasmid_TraJ; TIGR02525
223283017469	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
223283017470	ATP binding site [chemical binding]; other site
223283017471	Walker B motif; other site
223283017472	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
223283017473	PLD-like domain; Region: PLDc_2; pfam13091
223283017474	putative active site [active]
223283017475	catalytic site [active]
223283017476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
223283017477	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
223283017478	active site
223283017479	metal binding site [ion binding]; metal-binding site
223283017480	interdomain interaction site; other site
223283017481	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
223283017482	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
223283017483	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
223283017484	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
223283017485	AAA-like domain; Region: AAA_10; pfam12846
223283017486	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
223283017487	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
223283017488	dimerization domain [polypeptide binding]; other site
223283017489	dimer interface [polypeptide binding]; other site
223283017490	catalytic residues [active]
223283017491	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
223283017492	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
223283017493	Transcriptional regulators [Transcription]; Region: GntR; COG1802
223283017494	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
223283017495	DNA-binding site [nucleotide binding]; DNA binding site