-- dump date 20140620_020504 -- class Genbank::misc_feature -- table misc_feature_note -- id note 675635000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635000002 Walker A motif; other site 675635000003 ATP binding site [chemical binding]; other site 675635000004 Walker B motif; other site 675635000005 arginine finger; other site 675635000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 675635000007 DnaA box-binding interface [nucleotide binding]; other site 675635000008 DNA polymerase III subunit beta; Validated; Region: PRK07761 675635000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 675635000010 putative DNA binding surface [nucleotide binding]; other site 675635000011 dimer interface [polypeptide binding]; other site 675635000012 beta-clamp/clamp loader binding surface; other site 675635000013 beta-clamp/translesion DNA polymerase binding surface; other site 675635000014 recombination protein F; Reviewed; Region: recF; PRK00064 675635000015 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 675635000016 Walker A/P-loop; other site 675635000017 ATP binding site [chemical binding]; other site 675635000018 Q-loop/lid; other site 675635000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635000020 ABC transporter signature motif; other site 675635000021 Walker B; other site 675635000022 Protein of unknown function (DUF721); Region: DUF721; cl02324 675635000023 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 675635000024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635000025 Mg2+ binding site [ion binding]; other site 675635000026 G-X-G motif; other site 675635000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 675635000028 anchoring element; other site 675635000029 dimer interface [polypeptide binding]; other site 675635000030 ATP binding site [chemical binding]; other site 675635000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 675635000032 active site 675635000033 putative metal-binding site [ion binding]; other site 675635000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 675635000035 DNA gyrase subunit A; Validated; Region: PRK05560 675635000036 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 675635000037 CAP-like domain; other site 675635000038 active site 675635000039 primary dimer interface [polypeptide binding]; other site 675635000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 675635000046 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 675635000047 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635000048 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635000049 active site 675635000050 Int/Topo IB signature motif; other site 675635000051 DNA binding site [nucleotide binding] 675635000052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635000053 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 675635000054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635000055 Integrase core domain; Region: rve; pfam00665 675635000056 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 675635000057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635000058 Walker A motif; other site 675635000059 ATP binding site [chemical binding]; other site 675635000060 Walker B motif; other site 675635000061 arginine finger; other site 675635000062 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635000063 F420H2 dehydrogenase subunit FpoO; Region: FpoO; pfam10621 675635000064 MULE transposase domain; Region: MULE; pfam10551 675635000065 Isochorismatase family; Region: Isochorismatase; pfam00857 675635000066 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 675635000067 catalytic triad [active] 675635000068 conserved cis-peptide bond; other site 675635000069 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635000070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635000071 DNA-binding site [nucleotide binding]; DNA binding site 675635000072 Helix-turn-helix domain; Region: HTH_17; pfam12728 675635000073 transposase/IS protein; Provisional; Region: PRK09183 675635000074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635000075 Walker A motif; other site 675635000076 ATP binding site [chemical binding]; other site 675635000077 Walker B motif; other site 675635000078 arginine finger; other site 675635000079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635000080 Integrase core domain; Region: rve; pfam00665 675635000081 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 675635000082 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 675635000083 Walker A motif; other site 675635000084 ATP binding site [chemical binding]; other site 675635000085 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 675635000086 Walker B motif; other site 675635000087 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 675635000088 AAA domain; Region: AAA_30; pfam13604 675635000089 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 675635000090 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 675635000091 putative active site [active] 675635000092 putative NTP binding site [chemical binding]; other site 675635000093 putative nucleic acid binding site [nucleotide binding]; other site 675635000094 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 675635000095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635000096 dimerization interface [polypeptide binding]; other site 675635000097 putative DNA binding site [nucleotide binding]; other site 675635000098 putative Zn2+ binding site [ion binding]; other site 675635000099 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 675635000100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635000101 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 675635000102 MgtE intracellular N domain; Region: MgtE_N; pfam03448 675635000103 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 675635000104 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 675635000105 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 675635000106 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635000107 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 675635000108 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 675635000109 catalytic triad [active] 675635000110 DDE superfamily endonuclease; Region: DDE_5; pfam13546 675635000111 DDE superfamily endonuclease; Region: DDE_5; pfam13546 675635000112 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635000113 F420H2 dehydrogenase subunit FpoO; Region: FpoO; pfam10621 675635000114 MULE transposase domain; Region: MULE; pfam10551 675635000115 Transcriptional regulator [Transcription]; Region: LytR; COG1316 675635000116 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635000117 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 675635000118 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 675635000119 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635000120 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 675635000121 acyl-activating enzyme (AAE) consensus motif; other site 675635000122 AMP binding site [chemical binding]; other site 675635000123 active site 675635000124 CoA binding site [chemical binding]; other site 675635000125 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635000126 putative trimer interface [polypeptide binding]; other site 675635000127 putative CoA binding site [chemical binding]; other site 675635000128 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 675635000129 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635000130 putative trimer interface [polypeptide binding]; other site 675635000131 putative CoA binding site [chemical binding]; other site 675635000132 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 675635000133 cell division protein FtsW; Region: ftsW; TIGR02614 675635000134 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 675635000135 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 675635000136 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 675635000137 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635000138 Helix-turn-helix domain; Region: HTH_38; pfam13936 675635000139 Integrase core domain; Region: rve; pfam00665 675635000140 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635000141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635000142 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635000143 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635000144 FAD binding domain; Region: FAD_binding_4; pfam01565 675635000145 Berberine and berberine like; Region: BBE; pfam08031 675635000146 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 675635000147 DNA binding site [nucleotide binding] 675635000148 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635000149 AAA ATPase domain; Region: AAA_16; pfam13191 675635000150 Predicted ATPase [General function prediction only]; Region: COG3903 675635000151 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 675635000152 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 675635000153 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635000154 hypothetical protein; Provisional; Region: PRK06184 675635000155 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635000156 putative DNA binding site [nucleotide binding]; other site 675635000157 dimerization interface [polypeptide binding]; other site 675635000158 putative Zn2+ binding site [ion binding]; other site 675635000159 Low molecular weight phosphatase family; Region: LMWPc; cd00115 675635000160 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 675635000161 active site 675635000162 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635000163 active site 675635000164 metal binding site [ion binding]; metal-binding site 675635000165 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635000166 benzoate transport; Region: 2A0115; TIGR00895 675635000167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635000168 putative substrate translocation pore; other site 675635000169 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635000170 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635000171 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 675635000172 catalytic loop [active] 675635000173 iron binding site [ion binding]; other site 675635000174 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 675635000175 FAD binding pocket [chemical binding]; other site 675635000176 FAD binding motif [chemical binding]; other site 675635000177 phosphate binding motif [ion binding]; other site 675635000178 beta-alpha-beta structure motif; other site 675635000179 NAD binding pocket [chemical binding]; other site 675635000180 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 675635000181 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 675635000182 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 675635000183 inter-subunit interface; other site 675635000184 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 675635000185 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635000186 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635000187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635000188 S-adenosylmethionine binding site [chemical binding]; other site 675635000189 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 675635000190 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635000191 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635000192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635000193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635000194 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 675635000195 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 675635000196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635000197 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635000198 Walker A/P-loop; other site 675635000199 Walker A/P-loop; other site 675635000200 ATP binding site [chemical binding]; other site 675635000201 ATP binding site [chemical binding]; other site 675635000202 Q-loop/lid; other site 675635000203 ABC transporter signature motif; other site 675635000204 Walker B; other site 675635000205 D-loop; other site 675635000206 H-loop/switch region; other site 675635000207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635000208 Walker A/P-loop; other site 675635000209 ATP binding site [chemical binding]; other site 675635000210 Q-loop/lid; other site 675635000211 ABC transporter signature motif; other site 675635000212 Walker B; other site 675635000213 D-loop; other site 675635000214 H-loop/switch region; other site 675635000215 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 675635000216 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635000217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635000218 putative DNA binding site [nucleotide binding]; other site 675635000219 putative Zn2+ binding site [ion binding]; other site 675635000220 AsnC family; Region: AsnC_trans_reg; pfam01037 675635000221 CheB methylesterase; Region: CheB_methylest; pfam01339 675635000222 ANTAR domain; Region: ANTAR; pfam03861 675635000223 Protein of unknown function, DUF485; Region: DUF485; pfam04341 675635000224 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 675635000225 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 675635000226 Na binding site [ion binding]; other site 675635000227 HEAT repeats; Region: HEAT_2; pfam13646 675635000228 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 675635000229 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635000230 DNA binding residues [nucleotide binding] 675635000231 putative dimer interface [polypeptide binding]; other site 675635000232 HEAT repeats; Region: HEAT_2; pfam13646 675635000233 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 675635000234 active site 675635000235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 675635000236 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635000237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635000238 DNA binding residues [nucleotide binding] 675635000239 UPF0126 domain; Region: UPF0126; pfam03458 675635000240 RibD C-terminal domain; Region: RibD_C; cl17279 675635000241 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 675635000242 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635000243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635000244 DNA-binding site [nucleotide binding]; DNA binding site 675635000245 FCD domain; Region: FCD; pfam07729 675635000246 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 675635000247 putative active site [active] 675635000248 putative catalytic site [active] 675635000249 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 675635000250 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635000251 catalytic Zn binding site [ion binding]; other site 675635000252 structural Zn binding site [ion binding]; other site 675635000253 tetramer interface [polypeptide binding]; other site 675635000254 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635000255 MT-A70; Region: MT-A70; cl01947 675635000256 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635000257 WYL domain; Region: WYL; pfam13280 675635000258 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635000259 FAD binding domain; Region: FAD_binding_4; pfam01565 675635000260 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635000261 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635000262 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 675635000263 active site 675635000264 Rhomboid family; Region: Rhomboid; pfam01694 675635000265 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 675635000266 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 675635000267 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 675635000268 Glutamine amidotransferase class-I; Region: GATase; pfam00117 675635000269 glutamine binding [chemical binding]; other site 675635000270 catalytic triad [active] 675635000271 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635000272 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635000273 active site 675635000274 ATP binding site [chemical binding]; other site 675635000275 substrate binding site [chemical binding]; other site 675635000276 activation loop (A-loop); other site 675635000277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 675635000278 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635000279 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635000280 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635000281 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635000282 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635000283 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635000284 active site 675635000285 ATP binding site [chemical binding]; other site 675635000286 substrate binding site [chemical binding]; other site 675635000287 activation loop (A-loop); other site 675635000288 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 675635000289 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 675635000290 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 675635000291 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 675635000292 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 675635000293 active site 675635000294 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 675635000295 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 675635000296 phosphopeptide binding site; other site 675635000297 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 675635000298 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 675635000299 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 675635000300 phosphopeptide binding site; other site 675635000301 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 675635000302 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 675635000303 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 675635000304 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 675635000305 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635000306 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635000307 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635000308 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635000309 substrate binding site [chemical binding]; other site 675635000310 THF binding site; other site 675635000311 zinc-binding site [ion binding]; other site 675635000312 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 675635000313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635000314 motif II; other site 675635000315 Domain of unknown function DUF59; Region: DUF59; pfam01883 675635000316 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 675635000317 active site 675635000318 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 675635000319 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 675635000320 NAD binding site [chemical binding]; other site 675635000321 substrate binding site [chemical binding]; other site 675635000322 catalytic Zn binding site [ion binding]; other site 675635000323 structural Zn binding site [ion binding]; other site 675635000324 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635000325 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 675635000326 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635000327 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 675635000328 acyl-activating enzyme (AAE) consensus motif; other site 675635000329 putative AMP binding site [chemical binding]; other site 675635000330 putative active site [active] 675635000331 putative CoA binding site [chemical binding]; other site 675635000332 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635000333 CoenzymeA binding site [chemical binding]; other site 675635000334 subunit interaction site [polypeptide binding]; other site 675635000335 PHB binding site; other site 675635000336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000337 NAD(P) binding site [chemical binding]; other site 675635000338 active site 675635000339 NADH(P)-binding; Region: NAD_binding_10; pfam13460 675635000340 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 675635000341 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635000342 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635000343 Copper resistance protein D; Region: CopD; pfam05425 675635000344 CopC domain; Region: CopC; pfam04234 675635000345 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 675635000346 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 675635000347 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 675635000348 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 675635000349 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 675635000350 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 675635000351 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 675635000352 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 675635000353 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 675635000354 active site 675635000355 DNA binding site [nucleotide binding] 675635000356 YceI-like domain; Region: YceI; smart00867 675635000357 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635000358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635000359 putative substrate translocation pore; other site 675635000360 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635000361 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635000362 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635000363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635000364 putative Zn2+ binding site [ion binding]; other site 675635000365 putative DNA binding site [nucleotide binding]; other site 675635000366 Cupin domain; Region: Cupin_2; pfam07883 675635000367 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 675635000368 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 675635000369 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 675635000370 putative DNA binding site [nucleotide binding]; other site 675635000371 catalytic residue [active] 675635000372 putative H2TH interface [polypeptide binding]; other site 675635000373 putative catalytic residues [active] 675635000374 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 675635000375 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 675635000376 Histidine kinase; Region: His_kinase; pfam06580 675635000377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635000378 ATP binding site [chemical binding]; other site 675635000379 Mg2+ binding site [ion binding]; other site 675635000380 G-X-G motif; other site 675635000381 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 675635000382 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 675635000383 tandem repeat interface [polypeptide binding]; other site 675635000384 oligomer interface [polypeptide binding]; other site 675635000385 active site residues [active] 675635000386 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 675635000387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635000388 active site 675635000389 phosphorylation site [posttranslational modification] 675635000390 intermolecular recognition site; other site 675635000391 dimerization interface [polypeptide binding]; other site 675635000392 LytTr DNA-binding domain; Region: LytTR; smart00850 675635000393 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 675635000394 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 675635000395 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 675635000396 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 675635000397 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 675635000398 Na binding site [ion binding]; other site 675635000399 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635000400 active site residue [active] 675635000401 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 675635000402 SEC-C motif; Region: SEC-C; pfam02810 675635000403 short chain dehydrogenase; Provisional; Region: PRK07791 675635000404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000405 NAD(P) binding site [chemical binding]; other site 675635000406 active site 675635000407 CAAX protease self-immunity; Region: Abi; pfam02517 675635000408 Glucitol operon activator protein (GutM); Region: GutM; cl01890 675635000409 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 675635000410 prephenate dehydratase; Provisional; Region: PRK11898 675635000411 Prephenate dehydratase; Region: PDT; pfam00800 675635000412 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 675635000413 putative L-Phe binding site [chemical binding]; other site 675635000414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635000415 catalytic core [active] 675635000416 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 675635000417 Septum formation; Region: Septum_form; pfam13845 675635000418 Septum formation; Region: Septum_form; pfam13845 675635000419 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 675635000420 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 675635000421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635000422 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 675635000423 active site 675635000424 motif I; other site 675635000425 motif II; other site 675635000426 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 675635000427 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 675635000428 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 675635000429 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 675635000430 substrate binding site; other site 675635000431 tetramer interface; other site 675635000432 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 675635000433 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 675635000434 NAD binding site [chemical binding]; other site 675635000435 substrate binding site [chemical binding]; other site 675635000436 homodimer interface [polypeptide binding]; other site 675635000437 active site 675635000438 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635000439 Methyltransferase domain; Region: Methyltransf_18; pfam12847 675635000440 S-adenosylmethionine binding site [chemical binding]; other site 675635000441 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 675635000442 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 675635000443 Ligand binding site; other site 675635000444 Putative Catalytic site; other site 675635000445 DXD motif; other site 675635000446 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 675635000447 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 675635000448 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 675635000449 Probable Catalytic site; other site 675635000450 metal-binding site 675635000451 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 675635000452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 675635000453 UDP-galactopyranose mutase; Region: GLF; pfam03275 675635000454 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 675635000455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 675635000456 active site 675635000457 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635000458 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 675635000459 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635000460 active site 675635000461 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635000462 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 675635000463 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 675635000464 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 675635000465 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 675635000466 Nitroreductase family; Region: Nitroreductase; pfam00881 675635000467 FMN binding site [chemical binding]; other site 675635000468 dimer interface [polypeptide binding]; other site 675635000469 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 675635000470 classical (c) SDRs; Region: SDR_c; cd05233 675635000471 NAD(P) binding site [chemical binding]; other site 675635000472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000473 active site 675635000474 active site 675635000475 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635000476 FAD binding domain; Region: FAD_binding_4; pfam01565 675635000477 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 675635000478 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635000479 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635000480 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 675635000481 Walker A/P-loop; other site 675635000482 ATP binding site [chemical binding]; other site 675635000483 Q-loop/lid; other site 675635000484 ABC transporter signature motif; other site 675635000485 Walker B; other site 675635000486 D-loop; other site 675635000487 H-loop/switch region; other site 675635000488 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635000489 putative DNA binding site [nucleotide binding]; other site 675635000490 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635000491 putative Zn2+ binding site [ion binding]; other site 675635000492 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635000493 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635000494 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635000495 DNA binding residues [nucleotide binding] 675635000496 dimerization interface [polypeptide binding]; other site 675635000497 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 675635000498 Predicted membrane protein [Function unknown]; Region: COG2246 675635000499 GtrA-like protein; Region: GtrA; pfam04138 675635000500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635000501 active site 675635000502 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 675635000503 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 675635000504 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 675635000505 Walker A/P-loop; other site 675635000506 ATP binding site [chemical binding]; other site 675635000507 Q-loop/lid; other site 675635000508 ABC transporter signature motif; other site 675635000509 Walker B; other site 675635000510 D-loop; other site 675635000511 H-loop/switch region; other site 675635000512 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 675635000513 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 675635000514 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 675635000515 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 675635000516 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 675635000517 NAD(P) binding site [chemical binding]; other site 675635000518 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 675635000519 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 675635000520 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 675635000521 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635000522 MarR family; Region: MarR_2; pfam12802 675635000523 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635000524 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635000525 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635000526 catalytic site [active] 675635000527 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 675635000528 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 675635000529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635000530 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 675635000531 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635000532 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 675635000533 active site 675635000534 metal binding site [ion binding]; metal-binding site 675635000535 Cupin domain; Region: Cupin_2; cl17218 675635000536 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635000537 classical (c) SDRs; Region: SDR_c; cd05233 675635000538 NAD(P) binding site [chemical binding]; other site 675635000539 active site 675635000540 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635000541 Cytochrome P450; Region: p450; cl12078 675635000542 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635000543 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635000544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635000545 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 675635000546 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635000547 putative NAD(P) binding site [chemical binding]; other site 675635000548 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 675635000549 active site 675635000550 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 675635000551 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 675635000552 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 675635000553 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 675635000554 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 675635000555 active site 675635000556 metal binding site [ion binding]; metal-binding site 675635000557 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 675635000558 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 675635000559 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 675635000560 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 675635000561 active site 675635000562 Zn binding site [ion binding]; other site 675635000563 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 675635000564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635000565 DNA binding site [nucleotide binding] 675635000566 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 675635000567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635000568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635000569 homodimer interface [polypeptide binding]; other site 675635000570 catalytic residue [active] 675635000571 Dienelactone hydrolase family; Region: DLH; pfam01738 675635000572 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 675635000573 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635000574 acyl-activating enzyme (AAE) consensus motif; other site 675635000575 AMP binding site [chemical binding]; other site 675635000576 active site 675635000577 CoA binding site [chemical binding]; other site 675635000578 NmrA-like family; Region: NmrA; pfam05368 675635000579 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 675635000580 NADP binding site [chemical binding]; other site 675635000581 active site 675635000582 regulatory binding site [polypeptide binding]; other site 675635000583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635000584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635000585 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 675635000586 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 675635000587 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635000588 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 675635000589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635000590 Zn2+ binding site [ion binding]; other site 675635000591 Mg2+ binding site [ion binding]; other site 675635000592 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635000593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635000594 DNA binding residues [nucleotide binding] 675635000595 dimerization interface [polypeptide binding]; other site 675635000596 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 675635000597 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 675635000598 putative active site [active] 675635000599 metal binding site [ion binding]; metal-binding site 675635000600 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 675635000601 ABC-ATPase subunit interface; other site 675635000602 dimer interface [polypeptide binding]; other site 675635000603 putative PBP binding regions; other site 675635000604 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 675635000605 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 675635000606 ABC-ATPase subunit interface; other site 675635000607 dimer interface [polypeptide binding]; other site 675635000608 putative PBP binding regions; other site 675635000609 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 675635000610 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 675635000611 intersubunit interface [polypeptide binding]; other site 675635000612 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 675635000613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635000614 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635000615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635000616 Walker A/P-loop; other site 675635000617 ATP binding site [chemical binding]; other site 675635000618 Q-loop/lid; other site 675635000619 ABC transporter signature motif; other site 675635000620 Walker B; other site 675635000621 D-loop; other site 675635000622 H-loop/switch region; other site 675635000623 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635000624 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 675635000625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635000626 Walker A/P-loop; other site 675635000627 ATP binding site [chemical binding]; other site 675635000628 Q-loop/lid; other site 675635000629 ABC transporter signature motif; other site 675635000630 Walker B; other site 675635000631 D-loop; other site 675635000632 H-loop/switch region; other site 675635000633 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 675635000634 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 675635000635 acyl-activating enzyme (AAE) consensus motif; other site 675635000636 AMP binding site [chemical binding]; other site 675635000637 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 675635000638 Condensation domain; Region: Condensation; pfam00668 675635000639 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 675635000640 Condensation domain; Region: Condensation; pfam00668 675635000641 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 675635000642 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 675635000643 acyl-activating enzyme (AAE) consensus motif; other site 675635000644 AMP binding site [chemical binding]; other site 675635000645 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 675635000646 Condensation domain; Region: Condensation; pfam00668 675635000647 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 675635000648 Condensation domain; Region: Condensation; pfam00668 675635000649 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 675635000650 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 675635000651 acyl-activating enzyme (AAE) consensus motif; other site 675635000652 AMP binding site [chemical binding]; other site 675635000653 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 675635000654 Condensation domain; Region: Condensation; pfam00668 675635000655 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 675635000656 Condensation domain; Region: Condensation; pfam00668 675635000657 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 675635000658 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 675635000659 acyl-activating enzyme (AAE) consensus motif; other site 675635000660 AMP binding site [chemical binding]; other site 675635000661 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 675635000662 Condensation domain; Region: Condensation; pfam00668 675635000663 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 675635000664 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 675635000665 acyl-activating enzyme (AAE) consensus motif; other site 675635000666 AMP binding site [chemical binding]; other site 675635000667 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 675635000668 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 675635000669 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 675635000670 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 675635000671 acyl-activating enzyme (AAE) consensus motif; other site 675635000672 AMP binding site [chemical binding]; other site 675635000673 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 675635000674 hypothetical protein; Provisional; Region: PRK06834 675635000675 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635000676 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635000677 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635000678 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 675635000679 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 675635000680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635000681 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635000682 DNA binding residues [nucleotide binding] 675635000683 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 675635000684 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 675635000685 MOSC domain; Region: MOSC; pfam03473 675635000686 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 675635000687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635000688 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635000689 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 675635000690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635000691 S-adenosylmethionine binding site [chemical binding]; other site 675635000692 GRAS family transcription factor; Region: GRAS; pfam03514 675635000693 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 675635000694 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635000695 active site 675635000696 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635000697 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 675635000698 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635000699 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635000700 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635000701 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 675635000702 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635000703 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635000704 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 675635000705 YCII-related domain; Region: YCII; cl00999 675635000706 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635000707 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635000708 active site 675635000709 non-prolyl cis peptide bond; other site 675635000710 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635000711 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635000712 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635000713 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635000714 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635000715 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 675635000716 SnoaL-like domain; Region: SnoaL_3; pfam13474 675635000717 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 675635000718 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635000719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635000720 putative substrate translocation pore; other site 675635000721 hypothetical protein; Provisional; Region: PRK06184 675635000722 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635000723 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 675635000724 catalytic triad [active] 675635000725 dimer interface [polypeptide binding]; other site 675635000726 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 675635000727 motif 1; other site 675635000728 dimer interface [polypeptide binding]; other site 675635000729 active site 675635000730 motif 2; other site 675635000731 motif 3; other site 675635000732 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 675635000733 Putative esterase; Region: Esterase; pfam00756 675635000734 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 675635000735 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635000736 putative metal binding site [ion binding]; other site 675635000737 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635000738 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635000739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635000740 NAD(P) binding site [chemical binding]; other site 675635000741 active site 675635000742 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635000743 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635000744 NAD(P) binding site [chemical binding]; other site 675635000745 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 675635000746 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 675635000747 DNA binding site [nucleotide binding] 675635000748 active site 675635000749 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 675635000750 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 675635000751 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635000752 DNA binding residues [nucleotide binding] 675635000753 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635000754 acyl-CoA synthetase; Validated; Region: PRK07787 675635000755 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635000756 acyl-activating enzyme (AAE) consensus motif; other site 675635000757 AMP binding site [chemical binding]; other site 675635000758 active site 675635000759 CoA binding site [chemical binding]; other site 675635000760 enoyl-CoA hydratase; Provisional; Region: PRK06127 675635000761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635000762 substrate binding site [chemical binding]; other site 675635000763 oxyanion hole (OAH) forming residues; other site 675635000764 trimer interface [polypeptide binding]; other site 675635000765 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635000766 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635000767 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 675635000768 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 675635000769 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 675635000770 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635000771 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635000772 active site 675635000773 catalytic tetrad [active] 675635000774 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 675635000775 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635000776 active site 675635000777 dimer interface [polypeptide binding]; other site 675635000778 metal binding site [ion binding]; metal-binding site 675635000779 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 675635000780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635000781 motif II; other site 675635000782 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 675635000783 nucleotide binding site [chemical binding]; other site 675635000784 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635000785 MULE transposase domain; Region: MULE; pfam10551 675635000786 hypothetical protein; Provisional; Region: PRK06541 675635000787 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635000788 inhibitor-cofactor binding pocket; inhibition site 675635000789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635000790 catalytic residue [active] 675635000791 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635000792 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 675635000793 homodimer interface [polypeptide binding]; other site 675635000794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635000795 catalytic residue [active] 675635000796 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 675635000797 ABC1 family; Region: ABC1; cl17513 675635000798 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635000799 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 675635000800 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 675635000801 Walker A/P-loop; other site 675635000802 ATP binding site [chemical binding]; other site 675635000803 Q-loop/lid; other site 675635000804 ABC transporter signature motif; other site 675635000805 Walker B; other site 675635000806 D-loop; other site 675635000807 H-loop/switch region; other site 675635000808 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635000809 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 675635000810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635000811 Walker A/P-loop; other site 675635000812 ATP binding site [chemical binding]; other site 675635000813 Q-loop/lid; other site 675635000814 ABC transporter signature motif; other site 675635000815 Walker B; other site 675635000816 D-loop; other site 675635000817 H-loop/switch region; other site 675635000818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635000819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635000820 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635000821 anti sigma factor interaction site; other site 675635000822 regulatory phosphorylation site [posttranslational modification]; other site 675635000823 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635000824 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635000825 TIGR03086 family protein; Region: TIGR03086 675635000826 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635000827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635000828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635000829 active site 675635000830 phosphorylation site [posttranslational modification] 675635000831 intermolecular recognition site; other site 675635000832 dimerization interface [polypeptide binding]; other site 675635000833 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635000834 DNA binding residues [nucleotide binding] 675635000835 dimerization interface [polypeptide binding]; other site 675635000836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635000837 Histidine kinase; Region: HisKA_3; pfam07730 675635000838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635000839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635000840 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 675635000841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635000842 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 675635000843 Walker A/P-loop; other site 675635000844 ATP binding site [chemical binding]; other site 675635000845 Q-loop/lid; other site 675635000846 ABC transporter signature motif; other site 675635000847 Walker B; other site 675635000848 D-loop; other site 675635000849 H-loop/switch region; other site 675635000850 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 675635000851 ABC-2 type transporter; Region: ABC2_membrane; cl17235 675635000852 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 675635000853 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635000854 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 675635000855 Zn binding site [ion binding]; other site 675635000856 Transcriptional regulator [Transcription]; Region: LytR; COG1316 675635000857 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 675635000858 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 675635000859 putative DNA binding site [nucleotide binding]; other site 675635000860 putative homodimer interface [polypeptide binding]; other site 675635000861 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 675635000862 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 675635000863 active site 675635000864 DNA binding site [nucleotide binding] 675635000865 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 675635000866 DNA binding site [nucleotide binding] 675635000867 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 675635000868 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 675635000869 prephenate dehydrogenase; Validated; Region: PRK06545 675635000870 prephenate dehydrogenase; Validated; Region: PRK08507 675635000871 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635000872 Amidase; Region: Amidase; cl11426 675635000873 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 675635000874 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 675635000875 metal binding site [ion binding]; metal-binding site 675635000876 dimer interface [polypeptide binding]; other site 675635000877 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 675635000878 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 675635000879 nucleoside/Zn binding site; other site 675635000880 dimer interface [polypeptide binding]; other site 675635000881 catalytic motif [active] 675635000882 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635000883 nudix motif; other site 675635000884 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 675635000885 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635000886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635000887 active site residue [active] 675635000888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635000889 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 675635000890 putative substrate translocation pore; other site 675635000891 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635000892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635000893 S-adenosylmethionine binding site [chemical binding]; other site 675635000894 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635000895 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635000896 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635000897 active site 675635000898 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635000899 PGAP1-like protein; Region: PGAP1; pfam07819 675635000900 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635000901 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 675635000902 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635000903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635000904 DNA-binding site [nucleotide binding]; DNA binding site 675635000905 FCD domain; Region: FCD; pfam07729 675635000906 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 675635000907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635000908 Walker A motif; other site 675635000909 ATP binding site [chemical binding]; other site 675635000910 Walker B motif; other site 675635000911 arginine finger; other site 675635000912 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 675635000913 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635000914 Soluble P-type ATPase [General function prediction only]; Region: COG4087 675635000915 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 675635000916 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 675635000917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635000918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635000919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635000920 dimerization interface [polypeptide binding]; other site 675635000921 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 675635000922 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 675635000923 active site 675635000924 metal binding site [ion binding]; metal-binding site 675635000925 hypothetical protein; Validated; Region: PRK00153 675635000926 recombination protein RecR; Reviewed; Region: recR; PRK00076 675635000927 RecR protein; Region: RecR; pfam02132 675635000928 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 675635000929 putative active site [active] 675635000930 putative metal-binding site [ion binding]; other site 675635000931 tetramer interface [polypeptide binding]; other site 675635000932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635000933 sequence-specific DNA binding site [nucleotide binding]; other site 675635000934 salt bridge; other site 675635000935 Domain of unknown function (DUF397); Region: DUF397; pfam04149 675635000936 2-isopropylmalate synthase; Validated; Region: PRK03739 675635000937 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 675635000938 active site 675635000939 catalytic residues [active] 675635000940 metal binding site [ion binding]; metal-binding site 675635000941 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 675635000942 aspartate kinase; Reviewed; Region: PRK06635 675635000943 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 675635000944 putative nucleotide binding site [chemical binding]; other site 675635000945 putative catalytic residues [active] 675635000946 putative Mg ion binding site [ion binding]; other site 675635000947 putative aspartate binding site [chemical binding]; other site 675635000948 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 675635000949 putative allosteric regulatory site; other site 675635000950 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 675635000951 putative allosteric regulatory residue; other site 675635000952 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 675635000953 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 675635000954 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 675635000955 active site clefts [active] 675635000956 zinc binding site [ion binding]; other site 675635000957 dimer interface [polypeptide binding]; other site 675635000958 Protein of unknown function, DUF393; Region: DUF393; pfam04134 675635000959 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 675635000960 ArsC family; Region: ArsC; pfam03960 675635000961 catalytic residues [active] 675635000962 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 675635000963 Predicted acetyltransferase [General function prediction only]; Region: COG2388 675635000964 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 675635000965 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635000966 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635000967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635000968 Cupin domain; Region: Cupin_2; pfam07883 675635000969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635000970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635000971 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635000972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635000973 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635000974 DNA binding residues [nucleotide binding] 675635000975 YCII-related domain; Region: YCII; cl00999 675635000976 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 675635000977 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 675635000978 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635000979 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 675635000980 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 675635000981 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 675635000982 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 675635000983 B12 binding site [chemical binding]; other site 675635000984 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635000985 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 675635000986 conserved cys residue [active] 675635000987 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 675635000988 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 675635000989 conserved cys residue [active] 675635000990 Carboxylesterase family; Region: COesterase; pfam00135 675635000991 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 675635000992 substrate binding pocket [chemical binding]; other site 675635000993 catalytic triad [active] 675635000994 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 675635000995 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 675635000996 putative active site [active] 675635000997 putative metal binding site [ion binding]; other site 675635000998 Yqey-like protein; Region: YqeY; cl17540 675635000999 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 675635001000 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 675635001001 active site 675635001002 interdomain interaction site; other site 675635001003 putative metal-binding site [ion binding]; other site 675635001004 nucleotide binding site [chemical binding]; other site 675635001005 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 675635001006 domain I; other site 675635001007 phosphate binding site [ion binding]; other site 675635001008 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 675635001009 domain II; other site 675635001010 domain III; other site 675635001011 nucleotide binding site [chemical binding]; other site 675635001012 DNA binding groove [nucleotide binding] 675635001013 catalytic site [active] 675635001014 domain IV; other site 675635001015 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 675635001016 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 675635001017 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 675635001018 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 675635001019 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 675635001020 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 675635001021 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635001022 ATP binding site [chemical binding]; other site 675635001023 putative Mg++ binding site [ion binding]; other site 675635001024 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 675635001025 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 675635001026 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 675635001027 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 675635001028 Type II/IV secretion system protein; Region: T2SE; pfam00437 675635001029 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 675635001030 Walker A motif; other site 675635001031 hexamer interface [polypeptide binding]; other site 675635001032 ATP binding site [chemical binding]; other site 675635001033 Walker B motif; other site 675635001034 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 675635001035 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 675635001036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635001037 motif II; other site 675635001038 acetyl-CoA synthetase; Provisional; Region: PRK00174 675635001039 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 675635001040 active site 675635001041 CoA binding site [chemical binding]; other site 675635001042 acyl-activating enzyme (AAE) consensus motif; other site 675635001043 AMP binding site [chemical binding]; other site 675635001044 acetate binding site [chemical binding]; other site 675635001045 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635001046 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635001047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635001048 Walker A motif; other site 675635001049 ATP binding site [chemical binding]; other site 675635001050 Walker B motif; other site 675635001051 arginine finger; other site 675635001052 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 675635001053 Protein of unknown function DUF58; Region: DUF58; pfam01882 675635001054 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 675635001055 metal ion-dependent adhesion site (MIDAS); other site 675635001056 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635001057 metal ion-dependent adhesion site (MIDAS); other site 675635001058 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635001059 metal ion-dependent adhesion site (MIDAS); other site 675635001060 hypothetical protein; Provisional; Region: PRK09256 675635001061 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 675635001062 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 675635001063 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635001064 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635001065 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 675635001066 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 675635001067 active site 675635001068 catalytic site [active] 675635001069 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 675635001070 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 675635001071 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 675635001072 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 675635001073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635001074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635001075 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635001076 dimerization interface [polypeptide binding]; other site 675635001077 substrate binding pocket [chemical binding]; other site 675635001078 aspartate aminotransferase; Provisional; Region: PRK05764 675635001079 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635001080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635001081 homodimer interface [polypeptide binding]; other site 675635001082 catalytic residue [active] 675635001083 Ion channel; Region: Ion_trans_2; pfam07885 675635001084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635001085 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 675635001086 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635001087 catalytic residue [active] 675635001088 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 675635001089 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635001090 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635001091 DNA binding residues [nucleotide binding] 675635001092 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 675635001093 adenylosuccinate lyase; Region: purB; TIGR00928 675635001094 tetramer interface [polypeptide binding]; other site 675635001095 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 675635001096 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 675635001097 ATP binding site [chemical binding]; other site 675635001098 active site 675635001099 substrate binding site [chemical binding]; other site 675635001100 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 675635001101 putative active site [active] 675635001102 putative Zn binding site [ion binding]; other site 675635001103 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 675635001104 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 675635001105 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 675635001106 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 675635001107 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 675635001108 conserved cys residue [active] 675635001109 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 675635001110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001111 active site 675635001112 phosphorylation site [posttranslational modification] 675635001113 intermolecular recognition site; other site 675635001114 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 675635001115 CHASE3 domain; Region: CHASE3; pfam05227 675635001116 HAMP domain; Region: HAMP; pfam00672 675635001117 dimerization interface [polypeptide binding]; other site 675635001118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635001119 dimer interface [polypeptide binding]; other site 675635001120 phosphorylation site [posttranslational modification] 675635001121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635001122 ATP binding site [chemical binding]; other site 675635001123 Mg2+ binding site [ion binding]; other site 675635001124 G-X-G motif; other site 675635001125 Response regulator receiver domain; Region: Response_reg; pfam00072 675635001126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001127 active site 675635001128 phosphorylation site [posttranslational modification] 675635001129 intermolecular recognition site; other site 675635001130 dimerization interface [polypeptide binding]; other site 675635001131 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 675635001132 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 675635001133 dimerization interface [polypeptide binding]; other site 675635001134 ATP binding site [chemical binding]; other site 675635001135 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 675635001136 dimerization interface [polypeptide binding]; other site 675635001137 ATP binding site [chemical binding]; other site 675635001138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635001139 PAS domain; Region: PAS_9; pfam13426 675635001140 putative active site [active] 675635001141 heme pocket [chemical binding]; other site 675635001142 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635001143 metal binding site [ion binding]; metal-binding site 675635001144 active site 675635001145 I-site; other site 675635001146 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 675635001147 amidophosphoribosyltransferase; Provisional; Region: PRK07847 675635001148 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 675635001149 active site 675635001150 tetramer interface [polypeptide binding]; other site 675635001151 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635001152 active site 675635001153 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 675635001154 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 675635001155 dimerization interface [polypeptide binding]; other site 675635001156 putative ATP binding site [chemical binding]; other site 675635001157 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 675635001158 nudix motif; other site 675635001159 Predicted transcriptional regulators [Transcription]; Region: COG1725 675635001160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635001161 DNA-binding site [nucleotide binding]; DNA binding site 675635001162 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 675635001163 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 675635001164 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 675635001165 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 675635001166 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 675635001167 metal binding site 2 [ion binding]; metal-binding site 675635001168 putative DNA binding helix; other site 675635001169 metal binding site 1 [ion binding]; metal-binding site 675635001170 dimer interface [polypeptide binding]; other site 675635001171 structural Zn2+ binding site [ion binding]; other site 675635001172 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 675635001173 heme-binding site [chemical binding]; other site 675635001174 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 675635001175 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 675635001176 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 675635001177 active site residue [active] 675635001178 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 675635001179 active site residue [active] 675635001180 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 675635001181 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635001182 catalytic residues [active] 675635001183 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 675635001184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635001185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635001186 DNA binding site [nucleotide binding] 675635001187 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 675635001188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635001189 Coenzyme A binding pocket [chemical binding]; other site 675635001190 PBP superfamily domain; Region: PBP_like_2; cl17296 675635001191 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 675635001192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635001193 dimer interface [polypeptide binding]; other site 675635001194 conserved gate region; other site 675635001195 putative PBP binding loops; other site 675635001196 ABC-ATPase subunit interface; other site 675635001197 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 675635001198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635001199 dimer interface [polypeptide binding]; other site 675635001200 conserved gate region; other site 675635001201 putative PBP binding loops; other site 675635001202 ABC-ATPase subunit interface; other site 675635001203 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 675635001204 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 675635001205 Walker A/P-loop; other site 675635001206 ATP binding site [chemical binding]; other site 675635001207 Q-loop/lid; other site 675635001208 ABC transporter signature motif; other site 675635001209 Walker B; other site 675635001210 D-loop; other site 675635001211 H-loop/switch region; other site 675635001212 PhoU domain; Region: PhoU; pfam01895 675635001213 PhoU domain; Region: PhoU; pfam01895 675635001214 Dodecin; Region: Dodecin; pfam07311 675635001215 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 675635001216 PhoU domain; Region: PhoU; pfam01895 675635001217 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 675635001218 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635001219 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 675635001220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635001221 metal binding site [ion binding]; metal-binding site 675635001222 active site 675635001223 I-site; other site 675635001224 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 675635001225 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 675635001226 FMN binding site [chemical binding]; other site 675635001227 active site 675635001228 catalytic residues [active] 675635001229 substrate binding site [chemical binding]; other site 675635001230 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 675635001231 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 675635001232 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 675635001233 homotrimer interaction site [polypeptide binding]; other site 675635001234 putative active site [active] 675635001235 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 675635001236 homotrimer interaction site [polypeptide binding]; other site 675635001237 putative active site [active] 675635001238 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 675635001239 homotrimer interaction site [polypeptide binding]; other site 675635001240 putative active site [active] 675635001241 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 675635001242 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 675635001243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635001244 DNA-binding site [nucleotide binding]; DNA binding site 675635001245 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635001246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635001247 homodimer interface [polypeptide binding]; other site 675635001248 catalytic residue [active] 675635001249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001251 NADH(P)-binding; Region: NAD_binding_10; pfam13460 675635001252 NAD(P) binding site [chemical binding]; other site 675635001253 active site 675635001254 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635001255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001256 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 675635001257 active site 675635001258 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 675635001259 replication factor C large subunit; Provisional; Region: PRK04195 675635001260 CAAX protease self-immunity; Region: Abi; pfam02517 675635001261 SnoaL-like domain; Region: SnoaL_4; pfam13577 675635001262 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635001263 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635001264 active site 675635001265 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635001266 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635001267 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 675635001268 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635001269 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635001270 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635001271 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635001272 NAD(P) binding site [chemical binding]; other site 675635001273 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635001274 Cytochrome P450; Region: p450; cl12078 675635001275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635001276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635001277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635001278 dimerization interface [polypeptide binding]; other site 675635001279 putative DNA binding site [nucleotide binding]; other site 675635001280 putative Zn2+ binding site [ion binding]; other site 675635001281 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635001282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635001283 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635001284 AMP-binding domain protein; Validated; Region: PRK08315 675635001285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635001286 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 675635001287 acyl-activating enzyme (AAE) consensus motif; other site 675635001288 acyl-activating enzyme (AAE) consensus motif; other site 675635001289 putative AMP binding site [chemical binding]; other site 675635001290 putative active site [active] 675635001291 putative CoA binding site [chemical binding]; other site 675635001292 short chain dehydrogenase; Provisional; Region: PRK07791 675635001293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001294 NAD(P) binding site [chemical binding]; other site 675635001295 active site 675635001296 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 675635001297 lipoyl-biotinyl attachment site [posttranslational modification]; other site 675635001298 enoyl-CoA hydratase; Provisional; Region: PRK06688 675635001299 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635001300 substrate binding site [chemical binding]; other site 675635001301 oxyanion hole (OAH) forming residues; other site 675635001302 trimer interface [polypeptide binding]; other site 675635001303 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635001304 active site 2 [active] 675635001305 active site 1 [active] 675635001306 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 675635001307 Phosphotransferase enzyme family; Region: APH; pfam01636 675635001308 putative active site [active] 675635001309 putative substrate binding site [chemical binding]; other site 675635001310 ATP binding site [chemical binding]; other site 675635001311 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 675635001312 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635001313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635001314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635001315 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 675635001316 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 675635001317 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 675635001318 dimer interface [polypeptide binding]; other site 675635001319 active site 675635001320 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 675635001321 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635001322 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635001323 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635001324 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635001325 acyl-activating enzyme (AAE) consensus motif; other site 675635001326 acyl-activating enzyme (AAE) consensus motif; other site 675635001327 putative AMP binding site [chemical binding]; other site 675635001328 putative active site [active] 675635001329 putative CoA binding site [chemical binding]; other site 675635001330 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635001331 TM-ABC transporter signature motif; other site 675635001332 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635001333 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 675635001334 TM-ABC transporter signature motif; other site 675635001335 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635001336 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 675635001337 Walker A/P-loop; other site 675635001338 ATP binding site [chemical binding]; other site 675635001339 Q-loop/lid; other site 675635001340 ABC transporter signature motif; other site 675635001341 Walker B; other site 675635001342 D-loop; other site 675635001343 H-loop/switch region; other site 675635001344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635001345 Walker A/P-loop; other site 675635001346 ATP binding site [chemical binding]; other site 675635001347 ABC transporter; Region: ABC_tran; pfam00005 675635001348 Q-loop/lid; other site 675635001349 ABC transporter signature motif; other site 675635001350 Walker B; other site 675635001351 D-loop; other site 675635001352 H-loop/switch region; other site 675635001353 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635001354 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635001355 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635001356 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635001357 substrate binding site [chemical binding]; other site 675635001358 oxyanion hole (OAH) forming residues; other site 675635001359 trimer interface [polypeptide binding]; other site 675635001360 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 675635001361 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 675635001362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635001363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635001364 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635001365 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001366 active site 675635001367 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 675635001368 classical (c) SDRs; Region: SDR_c; cd05233 675635001369 NAD(P) binding site [chemical binding]; other site 675635001370 active site 675635001371 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635001372 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635001373 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 675635001374 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635001375 active site 675635001376 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635001377 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001378 active site 675635001379 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635001380 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 675635001381 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001382 active site 675635001383 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 675635001384 Protein export membrane protein; Region: SecD_SecF; cl14618 675635001385 Protein export membrane protein; Region: SecD_SecF; cl14618 675635001386 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 675635001387 NADP+ binding site [chemical binding]; other site 675635001388 folate binding site [chemical binding]; other site 675635001389 Cation efflux family; Region: Cation_efflux; cl00316 675635001390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635001391 dimerization interface [polypeptide binding]; other site 675635001392 putative DNA binding site [nucleotide binding]; other site 675635001393 putative Zn2+ binding site [ion binding]; other site 675635001394 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 675635001395 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 675635001396 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635001397 catalytic residue [active] 675635001398 Protein of unknown function DUF111; Region: DUF111; cl03398 675635001399 Tic20-like protein; Region: Tic20; pfam09685 675635001400 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 675635001401 classical (c) SDRs; Region: SDR_c; cd05233 675635001402 NAD(P) binding site [chemical binding]; other site 675635001403 active site 675635001404 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 675635001405 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 675635001406 quinone interaction residues [chemical binding]; other site 675635001407 active site 675635001408 catalytic residues [active] 675635001409 FMN binding site [chemical binding]; other site 675635001410 substrate binding site [chemical binding]; other site 675635001411 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 675635001412 RNA binding surface [nucleotide binding]; other site 675635001413 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635001414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001415 NAD(P) binding site [chemical binding]; other site 675635001416 active site 675635001417 EthD domain; Region: EthD; cl17553 675635001418 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 675635001419 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635001420 putative AMP binding site [chemical binding]; other site 675635001421 putative active site [active] 675635001422 acyl-activating enzyme (AAE) consensus motif; other site 675635001423 putative CoA binding site [chemical binding]; other site 675635001424 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 675635001425 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 675635001426 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635001427 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635001428 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 675635001429 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635001430 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 675635001431 Response regulator receiver domain; Region: Response_reg; pfam00072 675635001432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001433 active site 675635001434 phosphorylation site [posttranslational modification] 675635001435 intermolecular recognition site; other site 675635001436 dimerization interface [polypeptide binding]; other site 675635001437 PAS domain S-box; Region: sensory_box; TIGR00229 675635001438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635001439 putative active site [active] 675635001440 heme pocket [chemical binding]; other site 675635001441 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 675635001442 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635001443 GAF domain; Region: GAF; pfam01590 675635001444 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635001445 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 675635001446 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 675635001447 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 675635001448 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635001449 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 675635001450 ATP binding site [chemical binding]; other site 675635001451 Mg2+ binding site [ion binding]; other site 675635001452 G-X-G motif; other site 675635001453 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635001454 anti sigma factor interaction site; other site 675635001455 regulatory phosphorylation site [posttranslational modification]; other site 675635001456 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 675635001457 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635001458 active site residue [active] 675635001459 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001460 acyl-coenzyme A oxidase; Region: PLN02526 675635001461 active site 675635001462 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 675635001463 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 675635001464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635001465 ATP binding site [chemical binding]; other site 675635001466 putative Mg++ binding site [ion binding]; other site 675635001467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635001468 nucleotide binding region [chemical binding]; other site 675635001469 ATP-binding site [chemical binding]; other site 675635001470 Helicase associated domain (HA2); Region: HA2; pfam04408 675635001471 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 675635001472 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 675635001473 Beta-lactamase; Region: Beta-lactamase; pfam00144 675635001474 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 675635001475 Protein of unknown function DUF72; Region: DUF72; pfam01904 675635001476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001477 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635001478 acyl-CoA synthetase; Validated; Region: PRK08162 675635001479 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 675635001480 acyl-activating enzyme (AAE) consensus motif; other site 675635001481 putative active site [active] 675635001482 AMP binding site [chemical binding]; other site 675635001483 putative CoA binding site [chemical binding]; other site 675635001484 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 675635001485 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 675635001486 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 675635001487 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 675635001488 acyl-activating enzyme (AAE) consensus motif; other site 675635001489 putative AMP binding site [chemical binding]; other site 675635001490 putative active site [active] 675635001491 putative CoA binding site [chemical binding]; other site 675635001492 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635001493 active site 675635001494 catalytic triad [active] 675635001495 oxyanion hole [active] 675635001496 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635001497 metal-binding site [ion binding] 675635001498 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 675635001499 putative homotetramer interface [polypeptide binding]; other site 675635001500 putative homodimer interface [polypeptide binding]; other site 675635001501 putative allosteric switch controlling residues; other site 675635001502 putative metal binding site [ion binding]; other site 675635001503 putative homodimer-homodimer interface [polypeptide binding]; other site 675635001504 FAD binding domain; Region: FAD_binding_3; pfam01494 675635001505 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 675635001506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635001507 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635001508 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635001509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635001510 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 675635001511 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 675635001512 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635001513 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 675635001514 DXD motif; other site 675635001515 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 675635001516 active site 675635001517 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 675635001518 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 675635001519 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635001520 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 675635001521 DXD motif; other site 675635001522 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 675635001523 Cupin domain; Region: Cupin_2; pfam07883 675635001524 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635001525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635001526 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 675635001527 DNA-binding site [nucleotide binding]; DNA binding site 675635001528 RNA-binding motif; other site 675635001529 Protein of unknown function (DUF445); Region: DUF445; pfam04286 675635001530 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 675635001531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635001532 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 675635001533 Walker A/P-loop; other site 675635001534 ATP binding site [chemical binding]; other site 675635001535 Q-loop/lid; other site 675635001536 ABC transporter signature motif; other site 675635001537 Walker B; other site 675635001538 D-loop; other site 675635001539 H-loop/switch region; other site 675635001540 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 675635001541 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 675635001542 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 675635001543 CrcB-like protein; Region: CRCB; pfam02537 675635001544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635001545 non-specific DNA binding site [nucleotide binding]; other site 675635001546 salt bridge; other site 675635001547 sequence-specific DNA binding site [nucleotide binding]; other site 675635001548 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 675635001549 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 675635001550 putative deacylase active site [active] 675635001551 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 675635001552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635001553 Walker A motif; other site 675635001554 ATP binding site [chemical binding]; other site 675635001555 Walker B motif; other site 675635001556 arginine finger; other site 675635001557 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 675635001558 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 675635001559 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 675635001560 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 675635001561 putative active site [active] 675635001562 putative substrate binding site [chemical binding]; other site 675635001563 putative cosubstrate binding site; other site 675635001564 catalytic site [active] 675635001565 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 675635001566 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 675635001567 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 675635001568 FAD binding domain; Region: FAD_binding_4; pfam01565 675635001569 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 675635001570 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 675635001571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 675635001572 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 675635001573 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 675635001574 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 675635001575 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635001576 NAD(P) binding site [chemical binding]; other site 675635001577 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 675635001578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635001579 NAD(P) binding site [chemical binding]; other site 675635001580 active site 675635001581 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 675635001582 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 675635001583 H+ Antiporter protein; Region: 2A0121; TIGR00900 675635001584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001585 putative substrate translocation pore; other site 675635001586 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 675635001587 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 675635001588 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 675635001589 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635001590 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635001591 catalytic residue [active] 675635001592 citrate synthase 2; Provisional; Region: PRK12350 675635001593 Citrate synthase; Region: Citrate_synt; pfam00285 675635001594 oxalacetate binding site [chemical binding]; other site 675635001595 citrylCoA binding site [chemical binding]; other site 675635001596 coenzyme A binding site [chemical binding]; other site 675635001597 catalytic triad [active] 675635001598 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 675635001599 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 675635001600 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 675635001601 H+ Antiporter protein; Region: 2A0121; TIGR00900 675635001602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001603 putative substrate translocation pore; other site 675635001604 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 675635001605 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 675635001606 dimer interface [polypeptide binding]; other site 675635001607 active site 675635001608 citrylCoA binding site [chemical binding]; other site 675635001609 NADH binding [chemical binding]; other site 675635001610 cationic pore residues; other site 675635001611 oxalacetate/citrate binding site [chemical binding]; other site 675635001612 coenzyme A binding site [chemical binding]; other site 675635001613 catalytic triad [active] 675635001614 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 675635001615 DNA photolyase; Region: DNA_photolyase; pfam00875 675635001616 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 675635001617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635001618 hypothetical protein; Provisional; Region: PRK06834 675635001619 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635001620 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 675635001621 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 675635001622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635001623 Walker A/P-loop; other site 675635001624 ATP binding site [chemical binding]; other site 675635001625 Q-loop/lid; other site 675635001626 ABC transporter signature motif; other site 675635001627 Walker B; other site 675635001628 D-loop; other site 675635001629 H-loop/switch region; other site 675635001630 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635001631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635001632 DNA-binding site [nucleotide binding]; DNA binding site 675635001633 FCD domain; Region: FCD; pfam07729 675635001634 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 675635001635 DctM-like transporters; Region: DctM; pfam06808 675635001636 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635001637 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635001638 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635001639 acyl-activating enzyme (AAE) consensus motif; other site 675635001640 putative AMP binding site [chemical binding]; other site 675635001641 putative active site [active] 675635001642 putative CoA binding site [chemical binding]; other site 675635001643 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635001644 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635001645 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 675635001646 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 675635001647 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635001648 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635001649 thiolase; Provisional; Region: PRK06158 675635001650 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635001651 active site 675635001652 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635001653 GAF domain; Region: GAF; pfam01590 675635001654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635001655 Walker A motif; other site 675635001656 ATP binding site [chemical binding]; other site 675635001657 Walker B motif; other site 675635001658 arginine finger; other site 675635001659 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 675635001660 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635001661 dinuclear metal binding motif [ion binding]; other site 675635001662 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 675635001663 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635001664 catalytic loop [active] 675635001665 iron binding site [ion binding]; other site 675635001666 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 675635001667 FAD binding pocket [chemical binding]; other site 675635001668 conserved FAD binding motif [chemical binding]; other site 675635001669 phosphate binding motif [ion binding]; other site 675635001670 beta-alpha-beta structure motif; other site 675635001671 NAD binding pocket [chemical binding]; other site 675635001672 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 675635001673 dimerization interface [polypeptide binding]; other site 675635001674 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635001675 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 675635001676 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 675635001677 ring oligomerisation interface [polypeptide binding]; other site 675635001678 ATP/Mg binding site [chemical binding]; other site 675635001679 stacking interactions; other site 675635001680 hinge regions; other site 675635001681 Amidohydrolase; Region: Amidohydro_2; pfam04909 675635001682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001683 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635001684 putative substrate translocation pore; other site 675635001685 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 675635001686 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 675635001687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635001689 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635001690 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 675635001691 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 675635001692 NAD binding site [chemical binding]; other site 675635001693 catalytic Zn binding site [ion binding]; other site 675635001694 substrate binding site [chemical binding]; other site 675635001695 structural Zn binding site [ion binding]; other site 675635001696 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635001697 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635001698 substrate binding site [chemical binding]; other site 675635001699 oxyanion hole (OAH) forming residues; other site 675635001700 trimer interface [polypeptide binding]; other site 675635001701 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635001702 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 675635001703 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 675635001704 active site 675635001705 Cupin domain; Region: Cupin_2; pfam07883 675635001706 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635001707 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635001708 DNA binding residues [nucleotide binding] 675635001709 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 675635001710 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635001711 dimer interface [polypeptide binding]; other site 675635001712 active site 675635001713 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635001714 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 675635001715 substrate binding site [chemical binding]; other site 675635001716 oxyanion hole (OAH) forming residues; other site 675635001717 trimer interface [polypeptide binding]; other site 675635001718 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 675635001719 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 675635001720 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 675635001721 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 675635001722 GAF domain; Region: GAF_2; pfam13185 675635001723 ANTAR domain; Region: ANTAR; pfam03861 675635001724 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 675635001725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635001726 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 675635001727 Walker A/P-loop; other site 675635001728 ATP binding site [chemical binding]; other site 675635001729 Q-loop/lid; other site 675635001730 ABC transporter signature motif; other site 675635001731 Walker B; other site 675635001732 D-loop; other site 675635001733 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 675635001734 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 675635001735 Predicted permease; Region: DUF318; cl17795 675635001736 hypothetical protein; Provisional; Region: PRK06547 675635001737 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635001738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635001739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635001740 DNA binding residues [nucleotide binding] 675635001741 Putative zinc-finger; Region: zf-HC2; pfam13490 675635001742 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 675635001743 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 675635001744 NAD binding site [chemical binding]; other site 675635001745 catalytic Zn binding site [ion binding]; other site 675635001746 substrate binding site [chemical binding]; other site 675635001747 structural Zn binding site [ion binding]; other site 675635001748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635001749 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635001750 putative substrate translocation pore; other site 675635001751 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 675635001752 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 675635001753 NAD binding site [chemical binding]; other site 675635001754 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635001755 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 675635001756 active site 675635001757 NAD binding site [chemical binding]; other site 675635001758 metal binding site [ion binding]; metal-binding site 675635001759 galactonate dehydratase; Provisional; Region: PRK14017 675635001760 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 675635001761 metal binding site [ion binding]; metal-binding site 675635001762 substrate binding pocket [chemical binding]; other site 675635001763 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 675635001764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635001765 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635001766 dimerization interface [polypeptide binding]; other site 675635001767 substrate binding pocket [chemical binding]; other site 675635001768 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 675635001769 EamA-like transporter family; Region: EamA; pfam00892 675635001770 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 675635001771 homodimer interaction site [polypeptide binding]; other site 675635001772 cofactor binding site; other site 675635001773 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635001774 active site 675635001775 metal binding site [ion binding]; metal-binding site 675635001776 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635001777 GAF domain; Region: GAF; cl17456 675635001778 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 675635001779 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635001780 metal binding site [ion binding]; metal-binding site 675635001781 active site 675635001782 I-site; other site 675635001783 Predicted transcriptional regulators [Transcription]; Region: COG1733 675635001784 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635001785 dimerization interface [polypeptide binding]; other site 675635001786 putative DNA binding site [nucleotide binding]; other site 675635001787 putative Zn2+ binding site [ion binding]; other site 675635001788 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635001789 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635001790 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001791 Protein of unknown function (DUF664); Region: DUF664; pfam04978 675635001792 Protease prsW family; Region: PrsW-protease; pfam13367 675635001793 Predicted transcriptional regulators [Transcription]; Region: COG1733 675635001794 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 675635001795 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 675635001796 active site clefts [active] 675635001797 zinc binding site [ion binding]; other site 675635001798 dimer interface [polypeptide binding]; other site 675635001799 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635001800 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635001801 TM-ABC transporter signature motif; other site 675635001802 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635001803 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635001804 ligand binding site [chemical binding]; other site 675635001805 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635001806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635001807 DNA-binding site [nucleotide binding]; DNA binding site 675635001808 FCD domain; Region: FCD; pfam07729 675635001809 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635001810 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 675635001811 Walker A/P-loop; other site 675635001812 ATP binding site [chemical binding]; other site 675635001813 Q-loop/lid; other site 675635001814 ABC transporter signature motif; other site 675635001815 Walker B; other site 675635001816 D-loop; other site 675635001817 H-loop/switch region; other site 675635001818 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 675635001819 phenylhydantoinase; Validated; Region: PRK08323 675635001820 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635001821 active site 675635001822 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 675635001823 active site 675635001824 homodimer interface [polypeptide binding]; other site 675635001825 homotetramer interface [polypeptide binding]; other site 675635001826 tartrate dehydrogenase; Region: TTC; TIGR02089 675635001827 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 675635001828 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 675635001829 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 675635001830 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635001831 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635001832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635001833 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635001834 dimerization interface [polypeptide binding]; other site 675635001835 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 675635001836 tartrate dehydrogenase; Region: TTC; TIGR02089 675635001837 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 675635001838 YCII-related domain; Region: YCII; cl00999 675635001839 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635001840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635001841 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635001842 Predicted ATPase [General function prediction only]; Region: COG3903 675635001843 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635001844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635001845 DNA binding residues [nucleotide binding] 675635001846 dimerization interface [polypeptide binding]; other site 675635001847 FAD binding domain; Region: FAD_binding_3; pfam01494 675635001848 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 675635001849 adenosine deaminase; Provisional; Region: PRK09358 675635001850 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 675635001851 active site 675635001852 MMPL family; Region: MMPL; pfam03176 675635001853 MMPL family; Region: MMPL; pfam03176 675635001854 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 675635001855 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635001856 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635001857 Ligand Binding Site [chemical binding]; other site 675635001858 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635001859 Ligand Binding Site [chemical binding]; other site 675635001860 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 675635001861 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635001862 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635001863 FMN binding site [chemical binding]; other site 675635001864 dimer interface [polypeptide binding]; other site 675635001865 GAF domain; Region: GAF_3; pfam13492 675635001866 Histidine kinase; Region: HisKA_3; pfam07730 675635001867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635001868 ATP binding site [chemical binding]; other site 675635001869 G-X-G motif; other site 675635001870 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635001871 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635001872 Ligand Binding Site [chemical binding]; other site 675635001873 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635001874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001875 active site 675635001876 phosphorylation site [posttranslational modification] 675635001877 intermolecular recognition site; other site 675635001878 dimerization interface [polypeptide binding]; other site 675635001879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635001880 DNA binding residues [nucleotide binding] 675635001881 dimerization interface [polypeptide binding]; other site 675635001882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635001883 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635001884 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 675635001885 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 675635001886 active site 675635001887 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 675635001888 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 675635001889 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 675635001890 Uncharacterized conserved protein [Function unknown]; Region: COG1262 675635001891 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 675635001892 Sulfatase; Region: Sulfatase; pfam00884 675635001893 Sulfatase; Region: Sulfatase; cl17466 675635001894 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 675635001895 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 675635001896 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635001897 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635001898 active site 675635001899 Transcriptional regulator; Region: Rrf2; cl17282 675635001900 Rrf2 family protein; Region: rrf2_super; TIGR00738 675635001901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635001902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635001903 active site 675635001904 LytTr DNA-binding domain; Region: LytTR; smart00850 675635001905 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 675635001906 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 675635001907 heme binding site [chemical binding]; other site 675635001908 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 675635001909 heme binding site [chemical binding]; other site 675635001910 Actinobacterial PQQ system protein; Region: PQQ_MSMEG_3727; TIGR04339 675635001911 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 675635001912 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 675635001913 dimer interface [polypeptide binding]; other site 675635001914 Trp docking motif [polypeptide binding]; other site 675635001915 active site 675635001916 PqqA family; Region: PqqA; cl15372 675635001917 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 675635001918 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 675635001919 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 675635001920 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 675635001921 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 675635001922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635001923 FeS/SAM binding site; other site 675635001924 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 675635001925 Predicted membrane protein [Function unknown]; Region: COG1971 675635001926 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 675635001927 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 675635001928 SLBB domain; Region: SLBB; pfam10531 675635001929 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 675635001930 ApbE family; Region: ApbE; pfam02424 675635001931 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 675635001932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635001933 active site 675635001934 phosphorylation site [posttranslational modification] 675635001935 intermolecular recognition site; other site 675635001936 dimerization interface [polypeptide binding]; other site 675635001937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635001938 DNA binding site [nucleotide binding] 675635001939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635001940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635001941 ATP binding site [chemical binding]; other site 675635001942 Mg2+ binding site [ion binding]; other site 675635001943 G-X-G motif; other site 675635001944 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635001945 dimerization interface [polypeptide binding]; other site 675635001946 putative DNA binding site [nucleotide binding]; other site 675635001947 putative Zn2+ binding site [ion binding]; other site 675635001948 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 675635001949 hydrogenase 4 subunit B; Validated; Region: PRK06521 675635001950 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 675635001951 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 675635001952 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 675635001953 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 675635001954 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 675635001955 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 675635001956 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 675635001957 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 675635001958 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 675635001959 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 675635001960 active site 675635001961 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 675635001962 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 675635001963 active site 675635001964 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 675635001965 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635001966 catalytic loop [active] 675635001967 iron binding site [ion binding]; other site 675635001968 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 675635001969 FAD binding pocket [chemical binding]; other site 675635001970 FAD binding motif [chemical binding]; other site 675635001971 phosphate binding motif [ion binding]; other site 675635001972 beta-alpha-beta structure motif; other site 675635001973 NAD binding pocket [chemical binding]; other site 675635001974 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 675635001975 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635001976 dinuclear metal binding motif [ion binding]; other site 675635001977 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635001978 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635001979 dinuclear metal binding motif [ion binding]; other site 675635001980 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 675635001981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635001982 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635001983 dimerization interface [polypeptide binding]; other site 675635001984 substrate binding pocket [chemical binding]; other site 675635001985 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 675635001986 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635001987 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 675635001988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635001989 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635001990 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635001991 Coenzyme A transferase; Region: CoA_trans; cl17247 675635001992 Coenzyme A transferase; Region: CoA_trans; cl17247 675635001993 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635001994 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 675635001995 dimer interface [polypeptide binding]; other site 675635001996 active site 675635001997 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 675635001998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635001999 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635002000 dimerization interface [polypeptide binding]; other site 675635002001 substrate binding pocket [chemical binding]; other site 675635002002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635002003 Methyltransferase domain; Region: Methyltransf_31; pfam13847 675635002004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635002005 S-adenosylmethionine binding site [chemical binding]; other site 675635002006 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 675635002007 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 675635002008 putative active site [active] 675635002009 putative metal binding site [ion binding]; other site 675635002010 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635002011 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 675635002012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635002013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635002014 active site 675635002015 phosphorylation site [posttranslational modification] 675635002016 intermolecular recognition site; other site 675635002017 dimerization interface [polypeptide binding]; other site 675635002018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635002019 DNA binding site [nucleotide binding] 675635002020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635002021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 675635002022 dimerization interface [polypeptide binding]; other site 675635002023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635002024 dimer interface [polypeptide binding]; other site 675635002025 phosphorylation site [posttranslational modification] 675635002026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635002027 ATP binding site [chemical binding]; other site 675635002028 Mg2+ binding site [ion binding]; other site 675635002029 G-X-G motif; other site 675635002030 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635002031 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 675635002032 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 675635002033 MPT binding site; other site 675635002034 trimer interface [polypeptide binding]; other site 675635002035 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635002036 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635002037 putative NAD(P) binding site [chemical binding]; other site 675635002038 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 675635002039 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635002040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635002041 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635002042 dimerization interface [polypeptide binding]; other site 675635002043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002044 NAD(P) binding site [chemical binding]; other site 675635002045 active site 675635002046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002047 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 675635002048 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 675635002049 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 675635002050 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 675635002051 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 675635002052 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 675635002053 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 675635002054 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 675635002055 active site 675635002056 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 675635002057 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 675635002058 dimer interface [polypeptide binding]; other site 675635002059 putative functional site; other site 675635002060 putative MPT binding site; other site 675635002061 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 675635002062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 675635002063 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 675635002064 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 675635002065 catalytic residues [active] 675635002066 catalytic nucleophile [active] 675635002067 Presynaptic Site I dimer interface [polypeptide binding]; other site 675635002068 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 675635002069 Synaptic Flat tetramer interface [polypeptide binding]; other site 675635002070 Synaptic Site I dimer interface [polypeptide binding]; other site 675635002071 DNA binding site [nucleotide binding] 675635002072 Recombinase; Region: Recombinase; pfam07508 675635002073 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 675635002074 Replication-relaxation; Region: Replic_Relax; pfam13814 675635002075 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 675635002076 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635002077 E3 interaction surface; other site 675635002078 lipoyl attachment site [posttranslational modification]; other site 675635002079 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 675635002080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635002081 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635002082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635002083 Uncharacterized conserved protein [Function unknown]; Region: COG1359 675635002084 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cl00327 675635002085 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 675635002086 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 675635002087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635002088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635002089 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635002090 iron-sulfur cluster [ion binding]; other site 675635002091 [2Fe-2S] cluster binding site [ion binding]; other site 675635002092 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635002093 dinuclear metal binding motif [ion binding]; other site 675635002094 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635002095 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 675635002096 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635002097 dinuclear metal binding motif [ion binding]; other site 675635002098 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635002099 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635002100 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 675635002101 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 675635002102 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 675635002103 potential catalytic triad [active] 675635002104 conserved cys residue [active] 675635002105 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 675635002106 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 675635002107 potential catalytic triad [active] 675635002108 conserved cys residue [active] 675635002109 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 675635002110 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 675635002111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635002112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635002113 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 675635002114 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 675635002115 metal binding site [ion binding]; metal-binding site 675635002116 substrate binding pocket [chemical binding]; other site 675635002117 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635002118 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635002119 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 675635002120 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635002121 AsnC family; Region: AsnC_trans_reg; pfam01037 675635002122 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 675635002123 Predicted methyltransferases [General function prediction only]; Region: COG0313 675635002124 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 675635002125 putative SAM binding site [chemical binding]; other site 675635002126 putative homodimer interface [polypeptide binding]; other site 675635002127 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 675635002128 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 675635002129 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 675635002130 TrkA-C domain; Region: TrkA_C; pfam02080 675635002131 chorismate mutase; Provisional; Region: PRK09269 675635002132 Chorismate mutase type II; Region: CM_2; cl00693 675635002133 O-methyltransferase; Region: Methyltransf_2; pfam00891 675635002134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635002135 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 675635002136 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 675635002137 active site 675635002138 HIGH motif; other site 675635002139 KMSKS motif; other site 675635002140 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 675635002141 tRNA binding surface [nucleotide binding]; other site 675635002142 anticodon binding site; other site 675635002143 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 675635002144 active site 675635002145 Domain of unknown function (DUF348); Region: DUF348; pfam03990 675635002146 Domain of unknown function (DUF348); Region: DUF348; pfam03990 675635002147 G5 domain; Region: G5; pfam07501 675635002148 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 675635002149 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 675635002150 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 675635002151 Predicted transcriptional regulators [Transcription]; Region: COG1695 675635002152 Transcriptional regulator PadR-like family; Region: PadR; cl17335 675635002153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635002154 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635002155 putative substrate translocation pore; other site 675635002156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635002157 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 675635002158 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 675635002159 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 675635002160 ABC transporter; Region: ABC_tran_2; pfam12848 675635002161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 675635002162 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635002163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635002164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635002165 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 675635002166 Walker A/P-loop; other site 675635002167 ATP binding site [chemical binding]; other site 675635002168 Q-loop/lid; other site 675635002169 ABC transporter signature motif; other site 675635002170 Walker B; other site 675635002171 D-loop; other site 675635002172 H-loop/switch region; other site 675635002173 ABC-2 type transporter; Region: ABC2_membrane; cl17235 675635002174 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 675635002175 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 675635002176 DNA binding site [nucleotide binding] 675635002177 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635002178 AAA ATPase domain; Region: AAA_16; pfam13191 675635002179 Predicted ATPase [General function prediction only]; Region: COG3903 675635002180 hypothetical protein; Provisional; Region: PRK07907 675635002181 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 675635002182 active site 675635002183 metal binding site [ion binding]; metal-binding site 675635002184 dimer interface [polypeptide binding]; other site 675635002185 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 675635002186 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635002187 acyl-activating enzyme (AAE) consensus motif; other site 675635002188 AMP binding site [chemical binding]; other site 675635002189 active site 675635002190 CoA binding site [chemical binding]; other site 675635002191 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 675635002192 putative active site [active] 675635002193 catalytic residue [active] 675635002194 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 675635002195 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 675635002196 5S rRNA interface [nucleotide binding]; other site 675635002197 CTC domain interface [polypeptide binding]; other site 675635002198 L16 interface [polypeptide binding]; other site 675635002199 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635002200 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635002201 F420H2 dehydrogenase subunit FpoO; Region: FpoO; pfam10621 675635002202 MULE transposase domain; Region: MULE; pfam10551 675635002203 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 675635002204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635002205 Walker A motif; other site 675635002206 ATP binding site [chemical binding]; other site 675635002207 Walker B motif; other site 675635002208 arginine finger; other site 675635002209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635002210 Integrase core domain; Region: rve; pfam00665 675635002211 AAA domain; Region: AAA_25; pfam13481 675635002212 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 675635002213 Walker A motif; other site 675635002214 ATP binding site [chemical binding]; other site 675635002215 Walker B motif; other site 675635002216 Helix-turn-helix domain; Region: HTH_17; pfam12728 675635002217 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 675635002218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635002219 non-specific DNA binding site [nucleotide binding]; other site 675635002220 salt bridge; other site 675635002221 sequence-specific DNA binding site [nucleotide binding]; other site 675635002222 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 675635002223 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635002224 active site 675635002225 DNA binding site [nucleotide binding] 675635002226 Int/Topo IB signature motif; other site 675635002227 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 675635002228 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 675635002229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635002230 active site 675635002231 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 675635002232 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 675635002233 Substrate binding site; other site 675635002234 Mg++ binding site; other site 675635002235 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 675635002236 active site 675635002237 substrate binding site [chemical binding]; other site 675635002238 CoA binding site [chemical binding]; other site 675635002239 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 675635002240 OsmC-like protein; Region: OsmC; cl00767 675635002241 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635002242 Fatty acid desaturase; Region: FA_desaturase; pfam00487 675635002243 Di-iron ligands [ion binding]; other site 675635002244 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635002245 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 675635002246 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 675635002247 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 675635002248 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 675635002249 protein binding site [polypeptide binding]; other site 675635002250 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 675635002251 Domain interface; other site 675635002252 Peptide binding site; other site 675635002253 Active site tetrad [active] 675635002254 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635002255 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 675635002256 Walker A/P-loop; other site 675635002257 ATP binding site [chemical binding]; other site 675635002258 Q-loop/lid; other site 675635002259 ABC transporter signature motif; other site 675635002260 Walker B; other site 675635002261 D-loop; other site 675635002262 H-loop/switch region; other site 675635002263 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 675635002264 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 675635002265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635002266 ATP binding site [chemical binding]; other site 675635002267 putative Mg++ binding site [ion binding]; other site 675635002268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635002269 nucleotide binding region [chemical binding]; other site 675635002270 ATP-binding site [chemical binding]; other site 675635002271 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 675635002272 SurA N-terminal domain; Region: SurA_N_3; cl07813 675635002273 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 675635002274 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 675635002275 homodimer interface [polypeptide binding]; other site 675635002276 metal binding site [ion binding]; metal-binding site 675635002277 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635002278 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 675635002279 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 675635002280 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 675635002281 Imelysin; Region: Peptidase_M75; pfam09375 675635002282 Iron permease FTR1 family; Region: FTR1; cl00475 675635002283 Iron permease FTR1 family; Region: FTR1; cl00475 675635002284 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 675635002285 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 675635002286 Imelysin; Region: Peptidase_M75; pfam09375 675635002287 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 675635002288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 675635002289 binding surface 675635002290 TPR motif; other site 675635002291 TPR repeat; Region: TPR_11; pfam13414 675635002292 enolase; Provisional; Region: eno; PRK00077 675635002293 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 675635002294 dimer interface [polypeptide binding]; other site 675635002295 metal binding site [ion binding]; metal-binding site 675635002296 substrate binding pocket [chemical binding]; other site 675635002297 Protein of unknown function (DUF501); Region: DUF501; cl00652 675635002298 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635002299 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635002300 active site 675635002301 exopolyphosphatase; Region: exo_poly_only; TIGR03706 675635002302 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 675635002303 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 675635002304 Fe-S cluster binding site [ion binding]; other site 675635002305 DNA binding site [nucleotide binding] 675635002306 active site 675635002307 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 675635002308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635002309 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635002310 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635002311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002312 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 675635002313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635002314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 675635002315 dimerization interface [polypeptide binding]; other site 675635002316 RibD C-terminal domain; Region: RibD_C; cl17279 675635002317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635002318 Integrase core domain; Region: rve; pfam00665 675635002319 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 675635002320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635002321 Walker A motif; other site 675635002322 ATP binding site [chemical binding]; other site 675635002323 Walker B motif; other site 675635002324 arginine finger; other site 675635002325 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 675635002326 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 675635002327 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635002328 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635002329 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 675635002330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635002331 Coenzyme A binding pocket [chemical binding]; other site 675635002332 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635002333 dimerization interface [polypeptide binding]; other site 675635002334 putative DNA binding site [nucleotide binding]; other site 675635002335 putative Zn2+ binding site [ion binding]; other site 675635002336 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 675635002337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635002338 putative metal binding site [ion binding]; other site 675635002339 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635002340 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 675635002341 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 675635002342 hexamer interface [polypeptide binding]; other site 675635002343 active site 675635002344 metal binding site [ion binding]; metal-binding site 675635002345 Protein of unknown function (DUF419); Region: DUF419; cl15265 675635002346 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 675635002347 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 675635002348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 675635002349 Cupin domain; Region: Cupin_2; pfam07883 675635002350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635002351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635002352 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 675635002353 classical (c) SDRs; Region: SDR_c; cd05233 675635002354 NAD(P) binding site [chemical binding]; other site 675635002355 active site 675635002356 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635002357 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635002358 active site 675635002359 Bax inhibitor 1 like; Region: BaxI_1; cl17691 675635002360 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 675635002361 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635002362 dimer interface [polypeptide binding]; other site 675635002363 active site 675635002364 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635002365 YCII-related domain; Region: YCII; cl00999 675635002366 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635002367 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635002368 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 675635002369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635002370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635002371 DNA binding residues [nucleotide binding] 675635002372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635002373 Walker A/P-loop; other site 675635002374 ATP binding site [chemical binding]; other site 675635002375 FOG: WD40 repeat [General function prediction only]; Region: COG2319 675635002376 WD40 repeats; Region: WD40; smart00320 675635002377 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 675635002378 structural tetrad; other site 675635002379 FOG: WD40 repeat [General function prediction only]; Region: COG2319 675635002380 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 675635002381 structural tetrad; other site 675635002382 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 675635002383 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 675635002384 dimer interface [polypeptide binding]; other site 675635002385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002386 catalytic residue [active] 675635002387 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 675635002388 cystathionine gamma-synthase; Provisional; Region: PRK07811 675635002389 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 675635002390 homodimer interface [polypeptide binding]; other site 675635002391 substrate-cofactor binding pocket; other site 675635002392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002393 catalytic residue [active] 675635002394 threonine dehydratase; Provisional; Region: PRK08198 675635002395 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 675635002396 tetramer interface [polypeptide binding]; other site 675635002397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002398 catalytic residue [active] 675635002399 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 675635002400 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 675635002401 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 675635002402 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 675635002403 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 675635002404 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 675635002405 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 675635002406 catalytic residues [active] 675635002407 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 675635002408 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 675635002409 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 675635002410 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 675635002411 catalytic residue [active] 675635002412 putative FPP diphosphate binding site; other site 675635002413 putative FPP binding hydrophobic cleft; other site 675635002414 dimer interface [polypeptide binding]; other site 675635002415 putative IPP diphosphate binding site; other site 675635002416 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 675635002417 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 675635002418 putative active site [active] 675635002419 PhoH-like protein; Region: PhoH; pfam02562 675635002420 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 675635002421 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635002422 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 675635002423 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 675635002424 active site 675635002425 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 675635002426 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 675635002427 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635002428 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 675635002429 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 675635002430 active site 675635002431 DNA binding site [nucleotide binding] 675635002432 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 675635002433 DNA binding site [nucleotide binding] 675635002434 EAL domain; Region: EAL; pfam00563 675635002435 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635002436 fumarate hydratase; Reviewed; Region: fumC; PRK00485 675635002437 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 675635002438 active sites [active] 675635002439 tetramer interface [polypeptide binding]; other site 675635002440 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 675635002441 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 675635002442 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 675635002443 putative active site [active] 675635002444 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 675635002445 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 675635002446 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 675635002447 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 675635002448 generic binding surface II; other site 675635002449 generic binding surface I; other site 675635002450 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 675635002451 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 675635002452 RmuC family; Region: RmuC; pfam02646 675635002453 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 675635002454 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 675635002455 DNA binding site [nucleotide binding] 675635002456 active site 675635002457 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 675635002458 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 675635002459 AlkA N-terminal domain; Region: AlkA_N; pfam06029 675635002460 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 675635002461 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 675635002462 minor groove reading motif; other site 675635002463 helix-hairpin-helix signature motif; other site 675635002464 substrate binding pocket [chemical binding]; other site 675635002465 active site 675635002466 GTP-binding protein YchF; Reviewed; Region: PRK09601 675635002467 YchF GTPase; Region: YchF; cd01900 675635002468 G1 box; other site 675635002469 GTP/Mg2+ binding site [chemical binding]; other site 675635002470 Switch I region; other site 675635002471 G2 box; other site 675635002472 Switch II region; other site 675635002473 G3 box; other site 675635002474 G4 box; other site 675635002475 G5 box; other site 675635002476 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 675635002477 Predicted acyl esterases [General function prediction only]; Region: COG2936 675635002478 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 675635002479 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 675635002480 putative FMN binding site [chemical binding]; other site 675635002481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635002482 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 675635002483 DNA-binding interface [nucleotide binding]; DNA binding site 675635002484 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635002485 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635002486 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 675635002487 Part of AAA domain; Region: AAA_19; pfam13245 675635002488 Family description; Region: UvrD_C_2; pfam13538 675635002489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635002490 dimerization interface [polypeptide binding]; other site 675635002491 putative DNA binding site [nucleotide binding]; other site 675635002492 putative Zn2+ binding site [ion binding]; other site 675635002493 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 675635002494 putative hydrophobic ligand binding site [chemical binding]; other site 675635002495 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 675635002496 putative hydrophobic ligand binding site [chemical binding]; other site 675635002497 RibD C-terminal domain; Region: RibD_C; cl17279 675635002498 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 675635002499 CGNR zinc finger; Region: zf-CGNR; pfam11706 675635002500 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635002501 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 675635002502 putative dimer interface [polypeptide binding]; other site 675635002503 ligand binding site [chemical binding]; other site 675635002504 Zn binding site [ion binding]; other site 675635002505 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 675635002506 aromatic arch; other site 675635002507 DCoH dimer interaction site [polypeptide binding]; other site 675635002508 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 675635002509 DCoH tetramer interaction site [polypeptide binding]; other site 675635002510 substrate binding site [chemical binding]; other site 675635002511 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 675635002512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635002513 Walker A/P-loop; other site 675635002514 ATP binding site [chemical binding]; other site 675635002515 Q-loop/lid; other site 675635002516 ABC transporter signature motif; other site 675635002517 Walker B; other site 675635002518 D-loop; other site 675635002519 H-loop/switch region; other site 675635002520 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 675635002521 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635002522 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635002523 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635002524 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635002525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635002526 active site 675635002527 phosphorylation site [posttranslational modification] 675635002528 intermolecular recognition site; other site 675635002529 dimerization interface [polypeptide binding]; other site 675635002530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635002531 DNA binding site [nucleotide binding] 675635002532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635002533 dimer interface [polypeptide binding]; other site 675635002534 phosphorylation site [posttranslational modification] 675635002535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635002536 Mg2+ binding site [ion binding]; other site 675635002537 G-X-G motif; other site 675635002538 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635002539 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 675635002540 active site 675635002541 8-oxo-dGMP binding site [chemical binding]; other site 675635002542 nudix motif; other site 675635002543 metal binding site [ion binding]; metal-binding site 675635002544 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 675635002545 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 675635002546 G1 box; other site 675635002547 putative GEF interaction site [polypeptide binding]; other site 675635002548 GTP/Mg2+ binding site [chemical binding]; other site 675635002549 Switch I region; other site 675635002550 G2 box; other site 675635002551 G3 box; other site 675635002552 Switch II region; other site 675635002553 G4 box; other site 675635002554 G5 box; other site 675635002555 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 675635002556 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 675635002557 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 675635002558 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635002559 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635002560 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635002561 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635002562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635002563 dimer interface [polypeptide binding]; other site 675635002564 conserved gate region; other site 675635002565 putative PBP binding loops; other site 675635002566 ABC-ATPase subunit interface; other site 675635002567 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 675635002568 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635002569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635002570 dimer interface [polypeptide binding]; other site 675635002571 conserved gate region; other site 675635002572 putative PBP binding loops; other site 675635002573 ABC-ATPase subunit interface; other site 675635002574 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 675635002575 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635002576 Walker A/P-loop; other site 675635002577 ATP binding site [chemical binding]; other site 675635002578 Q-loop/lid; other site 675635002579 ABC transporter signature motif; other site 675635002580 Walker B; other site 675635002581 D-loop; other site 675635002582 H-loop/switch region; other site 675635002583 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 675635002584 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635002585 Walker A/P-loop; other site 675635002586 ATP binding site [chemical binding]; other site 675635002587 Q-loop/lid; other site 675635002588 ABC transporter signature motif; other site 675635002589 Walker B; other site 675635002590 D-loop; other site 675635002591 H-loop/switch region; other site 675635002592 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 675635002593 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635002594 Ferredoxin [Energy production and conversion]; Region: COG1146 675635002595 4Fe-4S binding domain; Region: Fer4; pfam00037 675635002596 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 675635002597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635002598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002599 homodimer interface [polypeptide binding]; other site 675635002600 catalytic residue [active] 675635002601 cyanate transporter; Region: CynX; TIGR00896 675635002602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635002603 putative substrate translocation pore; other site 675635002604 CHAD domain; Region: CHAD; pfam05235 675635002605 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 675635002606 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 675635002607 putative trimer interface [polypeptide binding]; other site 675635002608 putative CoA binding site [chemical binding]; other site 675635002609 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 675635002610 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 675635002611 metal binding site [ion binding]; metal-binding site 675635002612 putative dimer interface [polypeptide binding]; other site 675635002613 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 675635002614 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 675635002615 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 675635002616 dihydropteroate synthase; Region: DHPS; TIGR01496 675635002617 substrate binding pocket [chemical binding]; other site 675635002618 dimer interface [polypeptide binding]; other site 675635002619 inhibitor binding site; inhibition site 675635002620 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 675635002621 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 675635002622 active site 675635002623 DivIVA domain; Region: DivI1A_domain; TIGR03544 675635002624 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635002625 hydrophobic ligand binding site; other site 675635002626 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 675635002627 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 675635002628 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 675635002629 CGNR zinc finger; Region: zf-CGNR; pfam11706 675635002630 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 675635002631 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635002632 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 675635002633 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 675635002634 ligand binding site; other site 675635002635 oligomer interface; other site 675635002636 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 675635002637 dimer interface [polypeptide binding]; other site 675635002638 N-terminal domain interface [polypeptide binding]; other site 675635002639 sulfate 1 binding site; other site 675635002640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635002641 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635002642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635002643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635002644 DNA binding residues [nucleotide binding] 675635002645 serine endoprotease; Provisional; Region: PRK10898 675635002646 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635002647 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 675635002648 sec-independent translocase; Provisional; Region: PRK03100 675635002649 sec-independent translocase; Provisional; Region: tatB; PRK00404 675635002650 Alkylmercury lyase; Region: MerB; pfam03243 675635002651 putative amidase; Provisional; Region: PRK06169 675635002652 Amidase; Region: Amidase; cl11426 675635002653 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 675635002654 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 675635002655 NAD binding site [chemical binding]; other site 675635002656 ligand binding site [chemical binding]; other site 675635002657 catalytic site [active] 675635002658 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 675635002659 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635002660 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635002661 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635002662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635002663 DNA-binding site [nucleotide binding]; DNA binding site 675635002664 FCD domain; Region: FCD; pfam07729 675635002665 Predicted permeases [General function prediction only]; Region: COG0679 675635002666 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 675635002667 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635002668 inhibitor-cofactor binding pocket; inhibition site 675635002669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002670 catalytic residue [active] 675635002671 antiporter inner membrane protein; Provisional; Region: PRK11670 675635002672 Domain of unknown function DUF59; Region: DUF59; cl00941 675635002673 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 675635002674 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635002675 MarR family; Region: MarR; pfam01047 675635002676 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 675635002677 PRC-barrel domain; Region: PRC; pfam05239 675635002678 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 675635002679 MgtE intracellular N domain; Region: MgtE_N; smart00924 675635002680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 675635002681 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 675635002682 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 675635002683 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635002684 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635002685 active site 675635002686 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 675635002687 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 675635002688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635002689 dimer interface [polypeptide binding]; other site 675635002690 conserved gate region; other site 675635002691 putative PBP binding loops; other site 675635002692 ABC-ATPase subunit interface; other site 675635002693 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 675635002694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635002695 dimer interface [polypeptide binding]; other site 675635002696 conserved gate region; other site 675635002697 putative PBP binding loops; other site 675635002698 ABC-ATPase subunit interface; other site 675635002699 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 675635002700 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 675635002701 Walker A/P-loop; other site 675635002702 ATP binding site [chemical binding]; other site 675635002703 Q-loop/lid; other site 675635002704 ABC transporter signature motif; other site 675635002705 Walker B; other site 675635002706 D-loop; other site 675635002707 H-loop/switch region; other site 675635002708 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635002709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635002710 DNA-binding site [nucleotide binding]; DNA binding site 675635002711 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 675635002712 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 675635002713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635002714 catalytic residue [active] 675635002715 Helix-turn-helix domain; Region: HTH_38; pfam13936 675635002716 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635002717 Integrase core domain; Region: rve; pfam00665 675635002718 ParB-like nuclease domain; Region: ParB; smart00470 675635002719 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 675635002720 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 675635002721 active site 675635002722 metal binding site [ion binding]; metal-binding site 675635002723 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 675635002724 Methyltransferase domain; Region: Methyltransf_31; pfam13847 675635002725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635002726 S-adenosylmethionine binding site [chemical binding]; other site 675635002727 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635002728 iron-sulfur cluster [ion binding]; other site 675635002729 [2Fe-2S] cluster binding site [ion binding]; other site 675635002730 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 675635002731 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 675635002732 oligomer interface [polypeptide binding]; other site 675635002733 metal binding site [ion binding]; metal-binding site 675635002734 metal binding site [ion binding]; metal-binding site 675635002735 putative Cl binding site [ion binding]; other site 675635002736 basic sphincter; other site 675635002737 hydrophobic gate; other site 675635002738 periplasmic entrance; other site 675635002739 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 675635002740 putative active site [active] 675635002741 putative catalytic site [active] 675635002742 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635002743 nudix motif; other site 675635002744 Bacterial PH domain; Region: DUF304; pfam03703 675635002745 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 675635002746 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 675635002747 active site 675635002748 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 675635002749 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 675635002750 helicase 45; Provisional; Region: PTZ00424 675635002751 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 675635002752 ATP binding site [chemical binding]; other site 675635002753 Mg++ binding site [ion binding]; other site 675635002754 motif III; other site 675635002755 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635002756 nucleotide binding region [chemical binding]; other site 675635002757 ATP-binding site [chemical binding]; other site 675635002758 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 675635002759 dinuclear metal binding motif [ion binding]; other site 675635002760 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 675635002761 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 675635002762 Predicted membrane protein [Function unknown]; Region: COG1511 675635002763 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 675635002764 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 675635002765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 675635002766 Walker A/P-loop; other site 675635002767 ATP binding site [chemical binding]; other site 675635002768 Q-loop/lid; other site 675635002769 ABC transporter signature motif; other site 675635002770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635002771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635002772 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 675635002773 classical (c) SDRs; Region: SDR_c; cd05233 675635002774 NAD(P) binding site [chemical binding]; other site 675635002775 active site 675635002776 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 675635002777 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635002778 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635002779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635002780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635002781 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635002782 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635002783 metal-binding site [ion binding] 675635002784 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635002785 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635002786 TAP-like protein; Region: Abhydrolase_4; pfam08386 675635002787 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 675635002788 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 675635002789 ATP binding site [chemical binding]; other site 675635002790 substrate interface [chemical binding]; other site 675635002791 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635002792 active site residue [active] 675635002793 TIGR02569 family protein; Region: TIGR02569_actnb 675635002794 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 675635002795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635002796 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 675635002797 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 675635002798 [4Fe-4S] binding site [ion binding]; other site 675635002799 molybdopterin cofactor binding site; other site 675635002800 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 675635002801 molybdopterin cofactor binding site; other site 675635002802 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 675635002803 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 675635002804 nitrite reductase subunit NirD; Provisional; Region: PRK14989 675635002805 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 675635002806 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 675635002807 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 675635002808 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 675635002809 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 675635002810 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 675635002811 active site 675635002812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635002813 DNA binding site [nucleotide binding] 675635002814 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 675635002815 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 675635002816 putative active site [active] 675635002817 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 675635002818 active site 675635002819 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 675635002820 active site 675635002821 DNA binding site [nucleotide binding] 675635002822 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635002823 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635002824 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635002825 catalytic site [active] 675635002826 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 675635002827 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 675635002828 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 675635002829 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 675635002830 Part of AAA domain; Region: AAA_19; pfam13245 675635002831 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 675635002832 DoxX-like family; Region: DoxX_2; pfam13564 675635002833 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 675635002834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002835 NAD(P) binding site [chemical binding]; other site 675635002836 Ion channel; Region: Ion_trans_2; pfam07885 675635002837 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 675635002838 TrkA-N domain; Region: TrkA_N; pfam02254 675635002839 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 675635002840 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 675635002841 D-xylulose kinase; Region: XylB; TIGR01312 675635002842 nucleotide binding site [chemical binding]; other site 675635002843 xylose isomerase; Provisional; Region: PRK12677 675635002844 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 675635002845 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 675635002846 putative catalytic site [active] 675635002847 putative phosphate binding site [ion binding]; other site 675635002848 active site 675635002849 metal binding site A [ion binding]; metal-binding site 675635002850 DNA binding site [nucleotide binding] 675635002851 putative AP binding site [nucleotide binding]; other site 675635002852 putative metal binding site B [ion binding]; other site 675635002853 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 675635002854 active site 675635002855 putative catalytic site [active] 675635002856 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 675635002857 NAD(P) binding site [chemical binding]; other site 675635002858 catalytic residues [active] 675635002859 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635002860 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 675635002861 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 675635002862 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 675635002863 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 675635002864 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 675635002865 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 675635002866 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 675635002867 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 675635002868 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 675635002869 putative NADH binding site [chemical binding]; other site 675635002870 putative active site [active] 675635002871 nudix motif; other site 675635002872 putative metal binding site [ion binding]; other site 675635002873 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 675635002874 catalytic residues [active] 675635002875 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 675635002876 Family description; Region: UvrD_C_2; pfam13538 675635002877 HRDC domain; Region: HRDC; pfam00570 675635002878 Transcription factor WhiB; Region: Whib; pfam02467 675635002879 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 675635002880 ABC1 family; Region: ABC1; pfam03109 675635002881 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 675635002882 active site 675635002883 ATP binding site [chemical binding]; other site 675635002884 Protein of unknown function DUF45; Region: DUF45; cl00636 675635002885 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 675635002886 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 675635002887 hypothetical protein; Validated; Region: PRK00068 675635002888 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635002889 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 675635002890 Int/Topo IB signature motif; other site 675635002891 AAA domain; Region: AAA_25; pfam13481 675635002892 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 675635002893 Walker A motif; other site 675635002894 ATP binding site [chemical binding]; other site 675635002895 Walker B motif; other site 675635002896 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635002897 MarR family; Region: MarR_2; pfam12802 675635002898 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 675635002899 polymerase nucleotide-binding site; other site 675635002900 DNA-binding residues [nucleotide binding]; DNA binding site 675635002901 nucleotide binding site [chemical binding]; other site 675635002902 primase nucleotide-binding site [nucleotide binding]; other site 675635002903 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635002904 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 675635002905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635002906 DNA-binding site [nucleotide binding]; DNA binding site 675635002907 AAA domain; Region: AAA_33; pfam13671 675635002908 AAA domain; Region: AAA_17; pfam13207 675635002909 AAA domain; Region: AAA_17; cl17253 675635002910 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 675635002911 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 675635002912 synthetase active site [active] 675635002913 NTP binding site [chemical binding]; other site 675635002914 metal binding site [ion binding]; metal-binding site 675635002915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 675635002916 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 675635002917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 675635002918 Ion channel; Region: Ion_trans_2; pfam07885 675635002919 Sodium Bile acid symporter family; Region: SBF; cl17470 675635002920 SnoaL-like domain; Region: SnoaL_3; pfam13474 675635002921 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 675635002922 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 675635002923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635002924 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 675635002925 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635002926 RibD C-terminal domain; Region: RibD_C; cl17279 675635002927 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 675635002928 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635002929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635002930 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635002931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635002932 Integrase core domain; Region: rve; pfam00665 675635002933 transposase/IS protein; Provisional; Region: PRK09183 675635002934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635002935 Walker A motif; other site 675635002936 ATP binding site [chemical binding]; other site 675635002937 Walker B motif; other site 675635002938 arginine finger; other site 675635002939 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 675635002940 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 675635002941 conserved cys residue [active] 675635002942 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635002943 active site 675635002944 succinic semialdehyde dehydrogenase; Region: PLN02278 675635002945 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 675635002946 tetramerization interface [polypeptide binding]; other site 675635002947 NAD(P) binding site [chemical binding]; other site 675635002948 catalytic residues [active] 675635002949 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 675635002950 Na binding site [ion binding]; other site 675635002951 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635002952 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635002953 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635002954 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635002955 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 675635002956 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635002957 dinuclear metal binding motif [ion binding]; other site 675635002958 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 675635002959 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 675635002960 [2Fe-2S] cluster binding site [ion binding]; other site 675635002961 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635002962 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 675635002963 dimerization interface [polypeptide binding]; other site 675635002964 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635002965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635002966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635002967 short chain dehydrogenase; Provisional; Region: PRK12747 675635002968 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 675635002969 NADP binding site [chemical binding]; other site 675635002970 substrate binding site [chemical binding]; other site 675635002971 active site 675635002972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635002973 dimerization interface [polypeptide binding]; other site 675635002974 putative DNA binding site [nucleotide binding]; other site 675635002975 putative Zn2+ binding site [ion binding]; other site 675635002976 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635002977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635002978 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 675635002979 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 675635002980 short chain dehydrogenase; Provisional; Region: PRK05650 675635002981 classical (c) SDRs; Region: SDR_c; cd05233 675635002982 NAD(P) binding site [chemical binding]; other site 675635002983 active site 675635002984 Bacterial transcriptional activator domain; Region: BTAD; smart01043 675635002985 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 675635002986 RNA binding surface [nucleotide binding]; other site 675635002987 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 675635002988 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 675635002989 N-acetyl-D-glucosamine binding site [chemical binding]; other site 675635002990 catalytic residue [active] 675635002991 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 675635002992 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 675635002993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635002994 NAD(P) binding site [chemical binding]; other site 675635002995 active site 675635002996 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635002997 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 675635002998 DNA binding residues [nucleotide binding] 675635002999 NIPSNAP; Region: NIPSNAP; pfam07978 675635003000 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 675635003001 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 675635003002 active site 675635003003 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 675635003004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635003006 active site 675635003007 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003008 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635003009 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635003010 active site 675635003011 Transcriptional regulator PadR-like family; Region: PadR; cl17335 675635003012 peptide chain release factor 2; Validated; Region: prfB; PRK00578 675635003013 This domain is found in peptide chain release factors; Region: PCRF; smart00937 675635003014 RF-1 domain; Region: RF-1; pfam00472 675635003015 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 675635003016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635003017 Walker A/P-loop; other site 675635003018 ATP binding site [chemical binding]; other site 675635003019 Q-loop/lid; other site 675635003020 ABC transporter signature motif; other site 675635003021 Walker B; other site 675635003022 D-loop; other site 675635003023 H-loop/switch region; other site 675635003024 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 675635003025 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 675635003026 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 675635003027 SmpB-tmRNA interface; other site 675635003028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 675635003029 active site 675635003030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635003031 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635003032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635003033 putative substrate translocation pore; other site 675635003034 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 675635003035 Isochorismatase family; Region: Isochorismatase; pfam00857 675635003036 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 675635003037 catalytic triad [active] 675635003038 conserved cis-peptide bond; other site 675635003039 Isochorismatase family; Region: Isochorismatase; pfam00857 675635003040 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 675635003041 catalytic triad [active] 675635003042 conserved cis-peptide bond; other site 675635003043 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635003044 Amidase; Region: Amidase; cl11426 675635003045 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635003046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635003047 DNA-binding site [nucleotide binding]; DNA binding site 675635003048 FCD domain; Region: FCD; pfam07729 675635003049 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 675635003050 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635003051 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635003052 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635003053 Methylamine utilisation protein MauE; Region: MauE; pfam07291 675635003054 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 675635003055 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 675635003056 catalytic residues [active] 675635003057 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 675635003058 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 675635003059 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 675635003060 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635003061 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635003062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635003063 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635003064 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 675635003065 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 675635003066 catalytic residues [active] 675635003067 catalytic nucleophile [active] 675635003068 Recombinase; Region: Recombinase; pfam07508 675635003069 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 675635003070 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 675635003071 catalytic nucleophile [active] 675635003072 Resolvase, N terminal domain; Region: Resolvase; smart00857 675635003073 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 675635003074 catalytic residues [active] 675635003075 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 675635003076 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 675635003077 Recombinase; Region: Recombinase; pfam07508 675635003078 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 675635003079 DNA methylase; Region: N6_N4_Mtase; cl17433 675635003080 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635003081 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635003082 PrgI family protein; Region: PrgI; pfam12666 675635003083 AAA-like domain; Region: AAA_10; pfam12846 675635003084 Domain of unknown function DUF87; Region: DUF87; pfam01935 675635003085 Domain of unknown function DUF87; Region: DUF87; pfam01935 675635003086 AAA-like domain; Region: AAA_10; pfam12846 675635003087 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 675635003088 Replication-relaxation; Region: Replic_Relax; pfam13814 675635003089 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 675635003090 N-acetyl-D-glucosamine binding site [chemical binding]; other site 675635003091 catalytic residue [active] 675635003092 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635003093 NlpC/P60 family; Region: NLPC_P60; pfam00877 675635003094 Protein of unknown function DUF45; Region: DUF45; pfam01863 675635003095 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 675635003096 DNA protecting protein DprA; Region: dprA; TIGR00732 675635003097 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 675635003098 Active Sites [active] 675635003099 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 675635003100 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 675635003101 substrate binding site [chemical binding]; other site 675635003102 hexamer interface [polypeptide binding]; other site 675635003103 metal binding site [ion binding]; metal-binding site 675635003104 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 675635003105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635003106 motif II; other site 675635003107 AAA domain; Region: AAA_33; pfam13671 675635003108 AAA domain; Region: AAA_17; pfam13207 675635003109 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 675635003110 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 675635003111 active site 675635003112 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 675635003113 thymidylate kinase; Validated; Region: tmk; PRK00698 675635003114 active site 675635003115 Phosphotransferase enzyme family; Region: APH; pfam01636 675635003116 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 675635003117 active site 675635003118 ATP binding site [chemical binding]; other site 675635003119 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 675635003120 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635003121 Divergent AAA domain; Region: AAA_4; pfam04326 675635003122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635003123 Integrase core domain; Region: rve; pfam00665 675635003124 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 675635003125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635003126 Walker A motif; other site 675635003127 ATP binding site [chemical binding]; other site 675635003128 Walker B motif; other site 675635003129 arginine finger; other site 675635003130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635003131 ATP binding site [chemical binding]; other site 675635003132 putative Mg++ binding site [ion binding]; other site 675635003133 helicase superfamily c-terminal domain; Region: HELICc; smart00490 675635003134 Putative zinc-finger; Region: zf-HC2; pfam13490 675635003135 RNA polymerase sigma factor; Provisional; Region: PRK11924 675635003136 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635003137 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635003138 DNA binding residues [nucleotide binding] 675635003139 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 675635003140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635003141 FeS/SAM binding site; other site 675635003142 Methyltransferase domain; Region: Methyltransf_31; pfam13847 675635003143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635003144 S-adenosylmethionine binding site [chemical binding]; other site 675635003145 Domain of unknown function (DUF427); Region: DUF427; pfam04248 675635003146 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 675635003147 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 675635003148 Multicopper oxidase; Region: Cu-oxidase; pfam00394 675635003149 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635003150 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635003151 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635003152 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635003153 ligand binding site [chemical binding]; other site 675635003154 flexible hinge region; other site 675635003155 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 675635003156 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 675635003157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635003159 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635003160 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635003161 Methyltransferase domain; Region: Methyltransf_11; pfam08241 675635003162 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635003163 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 675635003164 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 675635003165 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635003166 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635003167 ligand binding site [chemical binding]; other site 675635003168 flexible hinge region; other site 675635003169 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 675635003170 Domain of unknown function DUF302; Region: DUF302; cl01364 675635003171 Domain of unknown function DUF302; Region: DUF302; cl01364 675635003172 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635003173 metal-binding site [ion binding] 675635003174 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 675635003175 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635003176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635003177 motif II; other site 675635003178 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635003179 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635003180 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635003181 metal-binding site [ion binding] 675635003182 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635003183 DNA binding residues [nucleotide binding] 675635003184 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 675635003185 putative catalytic residues [active] 675635003186 mercuric reductase; Validated; Region: PRK06370 675635003187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003188 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635003189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635003190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635003191 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 675635003192 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635003193 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635003194 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 675635003195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635003196 motif II; other site 675635003197 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 675635003198 catalytic residues [active] 675635003199 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 675635003200 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 675635003201 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 675635003202 catalytic residues [active] 675635003203 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 675635003204 putative homodimer interface [polypeptide binding]; other site 675635003205 putative homotetramer interface [polypeptide binding]; other site 675635003206 allosteric switch controlling residues; other site 675635003207 putative metal binding site [ion binding]; other site 675635003208 putative homodimer-homodimer interface [polypeptide binding]; other site 675635003209 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 675635003210 metal-binding site [ion binding] 675635003211 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635003212 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635003213 metal-binding site [ion binding] 675635003214 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635003215 Soluble P-type ATPase [General function prediction only]; Region: COG4087 675635003216 Putative zinc-finger; Region: zf-HC2; pfam13490 675635003217 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 675635003218 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635003219 DNA binding residues [nucleotide binding] 675635003220 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635003221 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635003222 DNA binding residues [nucleotide binding] 675635003223 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 675635003224 Alkylmercury lyase; Region: MerB; pfam03243 675635003225 alkylmercury lyase; Provisional; Region: PRK13239 675635003226 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 675635003227 Alkylmercury lyase; Region: MerB; pfam03243 675635003228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635003229 dimerization interface [polypeptide binding]; other site 675635003230 putative DNA binding site [nucleotide binding]; other site 675635003231 putative Zn2+ binding site [ion binding]; other site 675635003232 mercuric reductase; Region: MerA; TIGR02053 675635003233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003234 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635003235 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635003236 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635003237 DNA binding residues [nucleotide binding] 675635003238 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635003239 nudix motif; other site 675635003240 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 675635003241 DNA-binding interface [nucleotide binding]; DNA binding site 675635003242 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 675635003243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635003244 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 675635003245 non-specific DNA binding site [nucleotide binding]; other site 675635003246 salt bridge; other site 675635003247 sequence-specific DNA binding site [nucleotide binding]; other site 675635003248 Nitroreductase family; Region: Nitroreductase; pfam00881 675635003249 FMN binding site [chemical binding]; other site 675635003250 dimer interface [polypeptide binding]; other site 675635003251 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 675635003252 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635003253 active site 675635003254 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 675635003255 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 675635003256 acyl-activating enzyme (AAE) consensus motif; other site 675635003257 putative AMP binding site [chemical binding]; other site 675635003258 putative active site [active] 675635003259 putative CoA binding site [chemical binding]; other site 675635003260 GAF domain; Region: GAF_2; pfam13185 675635003261 GAF domain; Region: GAF; pfam01590 675635003262 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635003263 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 675635003264 dimer interface [polypeptide binding]; other site 675635003265 phosphate binding site [ion binding]; other site 675635003266 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635003267 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635003268 active site 675635003269 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 675635003270 dimer interface [polypeptide binding]; other site 675635003271 non-prolyl cis peptide bond; other site 675635003272 insertion regions; other site 675635003273 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 675635003274 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635003275 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 675635003276 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 675635003277 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 675635003278 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 675635003279 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 675635003280 dimer interface [polypeptide binding]; other site 675635003281 active site 675635003282 catalytic residue [active] 675635003283 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 675635003284 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635003285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635003286 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 675635003287 dimerization interface [polypeptide binding]; other site 675635003288 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 675635003289 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635003290 putative NAD(P) binding site [chemical binding]; other site 675635003291 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635003292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635003293 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 675635003294 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 675635003295 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635003296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635003297 DNA-binding site [nucleotide binding]; DNA binding site 675635003298 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 675635003299 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635003300 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635003301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635003302 acyl-activating enzyme (AAE) consensus motif; other site 675635003303 acyl-activating enzyme (AAE) consensus motif; other site 675635003304 AMP binding site [chemical binding]; other site 675635003305 active site 675635003306 CoA binding site [chemical binding]; other site 675635003307 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635003308 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635003309 substrate binding site [chemical binding]; other site 675635003310 oxyanion hole (OAH) forming residues; other site 675635003311 trimer interface [polypeptide binding]; other site 675635003312 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635003313 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003314 active site 675635003315 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003316 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635003317 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635003318 active site 675635003319 Putative cyclase; Region: Cyclase; pfam04199 675635003320 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635003321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635003322 DNA-binding site [nucleotide binding]; DNA binding site 675635003323 FCD domain; Region: FCD; pfam07729 675635003324 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635003325 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635003326 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635003327 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635003328 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 675635003329 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003330 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 675635003331 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635003332 Walker A/P-loop; other site 675635003333 ATP binding site [chemical binding]; other site 675635003334 Q-loop/lid; other site 675635003335 ABC transporter signature motif; other site 675635003336 Walker B; other site 675635003337 D-loop; other site 675635003338 H-loop/switch region; other site 675635003339 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 675635003340 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635003341 Walker A/P-loop; other site 675635003342 ATP binding site [chemical binding]; other site 675635003343 Q-loop/lid; other site 675635003344 ABC transporter signature motif; other site 675635003345 Walker B; other site 675635003346 D-loop; other site 675635003347 H-loop/switch region; other site 675635003348 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635003349 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635003350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635003351 dimer interface [polypeptide binding]; other site 675635003352 ABC-ATPase subunit interface; other site 675635003353 putative PBP binding loops; other site 675635003354 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635003355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635003356 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 675635003357 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635003358 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635003359 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 675635003360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003361 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 675635003362 NAD(P) binding site [chemical binding]; other site 675635003363 active site 675635003364 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635003365 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635003366 DNA-binding site [nucleotide binding]; DNA binding site 675635003367 FCD domain; Region: FCD; pfam07729 675635003368 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 675635003369 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 675635003370 dimer interface [polypeptide binding]; other site 675635003371 putative functional site; other site 675635003372 putative MPT binding site; other site 675635003373 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 675635003374 FMN binding site [chemical binding]; other site 675635003375 dimer interface [polypeptide binding]; other site 675635003376 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635003377 classical (c) SDRs; Region: SDR_c; cd05233 675635003378 NAD(P) binding site [chemical binding]; other site 675635003379 active site 675635003380 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635003381 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635003382 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635003383 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635003384 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 675635003385 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 675635003386 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 675635003387 dimerization interface [polypeptide binding]; other site 675635003388 active site 675635003389 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635003390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635003391 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003392 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635003393 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635003394 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 675635003395 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635003396 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635003397 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003398 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635003399 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635003400 DNA binding site [nucleotide binding] 675635003401 domain linker motif; other site 675635003402 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 675635003403 dimerization interface [polypeptide binding]; other site 675635003404 ligand binding site [chemical binding]; other site 675635003405 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635003406 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003407 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635003408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635003409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635003410 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 675635003411 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635003412 molybdopterin cofactor binding site; other site 675635003413 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 675635003414 molybdopterin cofactor binding site; other site 675635003415 Epoxide hydrolase N terminus; Region: EHN; pfam06441 675635003416 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635003417 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635003418 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635003419 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635003420 TM-ABC transporter signature motif; other site 675635003421 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635003422 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 675635003423 TM-ABC transporter signature motif; other site 675635003424 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635003425 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 675635003426 Walker A/P-loop; other site 675635003427 ATP binding site [chemical binding]; other site 675635003428 Q-loop/lid; other site 675635003429 ABC transporter signature motif; other site 675635003430 Walker B; other site 675635003431 D-loop; other site 675635003432 H-loop/switch region; other site 675635003433 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635003434 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 675635003435 Walker A/P-loop; other site 675635003436 ATP binding site [chemical binding]; other site 675635003437 Q-loop/lid; other site 675635003438 ABC transporter signature motif; other site 675635003439 Walker B; other site 675635003440 D-loop; other site 675635003441 H-loop/switch region; other site 675635003442 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635003443 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635003444 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003445 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635003446 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635003447 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635003448 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635003449 thiolase; Provisional; Region: PRK06158 675635003450 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635003451 active site 675635003452 choline dehydrogenase; Validated; Region: PRK02106 675635003453 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 675635003454 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635003455 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 675635003456 NAD(P) binding site [chemical binding]; other site 675635003457 catalytic residues [active] 675635003458 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635003459 active site 675635003460 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635003461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635003462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635003463 putative substrate translocation pore; other site 675635003464 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635003465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635003466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635003467 Winged helix-turn helix; Region: HTH_29; pfam13551 675635003468 Homeodomain-like domain; Region: HTH_32; pfam13565 675635003469 DDE superfamily endonuclease; Region: DDE_3; pfam13358 675635003470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 675635003471 Predicted acyl esterases [General function prediction only]; Region: COG2936 675635003472 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 675635003473 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635003474 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635003475 catalytic site [active] 675635003476 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635003477 TAP-like protein; Region: Abhydrolase_4; pfam08386 675635003478 Winged helix-turn helix; Region: HTH_29; pfam13551 675635003479 Homeodomain-like domain; Region: HTH_32; pfam13565 675635003480 DDE superfamily endonuclease; Region: DDE_3; pfam13358 675635003481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 675635003482 Lsr2; Region: Lsr2; pfam11774 675635003483 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 675635003484 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 675635003485 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 675635003486 RibD C-terminal domain; Region: RibD_C; cl17279 675635003487 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635003488 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 675635003489 putative NAD(P) binding site [chemical binding]; other site 675635003490 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 675635003491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635003492 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635003493 Sulfatase; Region: Sulfatase; cl17466 675635003494 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635003495 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 675635003496 AsnC family; Region: AsnC_trans_reg; pfam01037 675635003497 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 675635003498 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 675635003499 dimer interface [polypeptide binding]; other site 675635003500 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 675635003501 active site 675635003502 Fe binding site [ion binding]; other site 675635003503 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635003504 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 675635003505 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635003506 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635003507 active site 675635003508 metal binding site [ion binding]; metal-binding site 675635003509 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 675635003510 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635003511 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635003512 hydrophobic ligand binding site; other site 675635003513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635003514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635003515 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 675635003516 substrate binding pocket [chemical binding]; other site 675635003517 dimerization interface [polypeptide binding]; other site 675635003518 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635003519 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635003520 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 675635003521 active site 675635003522 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 675635003523 AMP binding site [chemical binding]; other site 675635003524 metal binding site [ion binding]; metal-binding site 675635003525 active site 675635003526 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635003527 Amidase; Region: Amidase; cl11426 675635003528 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 675635003529 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 675635003530 metal binding site 2 [ion binding]; metal-binding site 675635003531 putative DNA binding helix; other site 675635003532 metal binding site 1 [ion binding]; metal-binding site 675635003533 dimer interface [polypeptide binding]; other site 675635003534 structural Zn2+ binding site [ion binding]; other site 675635003535 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 675635003536 Ferritin-like domain; Region: Ferritin; pfam00210 675635003537 dimerization interface [polypeptide binding]; other site 675635003538 DPS ferroxidase diiron center [ion binding]; other site 675635003539 ion pore; other site 675635003540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635003541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635003542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635003543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635003544 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 675635003545 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 675635003546 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 675635003547 tetramer interface [polypeptide binding]; other site 675635003548 active site 675635003549 Mg2+/Mn2+ binding site [ion binding]; other site 675635003550 Uncharacterized conserved protein [Function unknown]; Region: COG0393 675635003551 Uncharacterized conserved protein [Function unknown]; Region: COG0393 675635003552 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 675635003553 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 675635003554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635003555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635003556 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 675635003557 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 675635003558 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 675635003559 potential catalytic triad [active] 675635003560 conserved cys residue [active] 675635003561 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635003562 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635003563 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635003564 dinuclear metal binding motif [ion binding]; other site 675635003565 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 675635003566 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635003567 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635003568 dinuclear metal binding motif [ion binding]; other site 675635003569 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 675635003570 [2Fe-2S] cluster binding site [ion binding]; other site 675635003571 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 675635003572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003573 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 675635003574 Uncharacterized conserved protein [Function unknown]; Region: COG1359 675635003575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635003576 non-specific DNA binding site [nucleotide binding]; other site 675635003577 salt bridge; other site 675635003578 sequence-specific DNA binding site [nucleotide binding]; other site 675635003579 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 675635003580 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 675635003581 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 675635003582 FAD binding domain; Region: FAD_binding_2; pfam00890 675635003583 hypothetical protein; Provisional; Region: PRK05858 675635003584 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635003585 PYR/PP interface [polypeptide binding]; other site 675635003586 dimer interface [polypeptide binding]; other site 675635003587 TPP binding site [chemical binding]; other site 675635003588 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 675635003589 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635003590 TPP-binding site [chemical binding]; other site 675635003591 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 675635003592 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635003593 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635003594 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635003595 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635003596 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 675635003597 amidase; Provisional; Region: PRK07235 675635003598 amidohydrolase, AtzE family; Region: amido_AtzE; TIGR02715 675635003599 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 675635003600 putative dimer interface [polypeptide binding]; other site 675635003601 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635003602 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 675635003603 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635003604 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635003605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635003606 DNA binding residues [nucleotide binding] 675635003607 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635003608 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635003609 classical (c) SDRs; Region: SDR_c; cd05233 675635003610 NAD(P) binding site [chemical binding]; other site 675635003611 active site 675635003612 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 675635003613 classical (c) SDRs; Region: SDR_c; cd05233 675635003614 NAD(P) binding site [chemical binding]; other site 675635003615 active site 675635003616 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635003617 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635003618 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635003619 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635003620 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635003621 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635003622 AsnC family; Region: AsnC_trans_reg; pfam01037 675635003623 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 675635003624 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 675635003625 dimer interface [polypeptide binding]; other site 675635003626 PYR/PP interface [polypeptide binding]; other site 675635003627 TPP binding site [chemical binding]; other site 675635003628 substrate binding site [chemical binding]; other site 675635003629 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635003630 TPP-binding site [chemical binding]; other site 675635003631 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 675635003632 hypothetical protein; Validated; Region: PRK07121 675635003633 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 675635003634 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635003635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635003636 DNA binding residues [nucleotide binding] 675635003637 dimerization interface [polypeptide binding]; other site 675635003638 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 675635003639 homotrimer interaction site [polypeptide binding]; other site 675635003640 putative active site [active] 675635003641 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635003642 FAD binding domain; Region: FAD_binding_4; pfam01565 675635003643 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 675635003644 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 675635003645 SnoaL-like domain; Region: SnoaL_3; pfam13474 675635003646 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635003647 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003648 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635003649 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635003650 Cytochrome P450; Region: p450; cl12078 675635003651 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 675635003652 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635003653 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 675635003654 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 675635003655 Predicted oxidoreductase [General function prediction only]; Region: COG3573 675635003656 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635003657 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635003658 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635003659 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 675635003660 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635003661 Cytochrome P450; Region: p450; cl12078 675635003662 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 675635003663 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 675635003664 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635003665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003666 NAD(P) binding site [chemical binding]; other site 675635003667 active site 675635003668 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 675635003669 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 675635003670 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 675635003671 conserved cys residue [active] 675635003672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635003673 Amidohydrolase; Region: Amidohydro_2; pfam04909 675635003674 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635003675 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635003676 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635003677 active site 675635003678 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635003679 classical (c) SDRs; Region: SDR_c; cd05233 675635003680 NAD(P) binding site [chemical binding]; other site 675635003681 active site 675635003682 Predicted transcriptional regulators [Transcription]; Region: COG1378 675635003683 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 675635003684 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 675635003685 C-terminal domain interface [polypeptide binding]; other site 675635003686 sugar binding site [chemical binding]; other site 675635003687 D-galactonate transporter; Region: 2A0114; TIGR00893 675635003688 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 675635003689 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 675635003690 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 675635003691 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635003692 substrate binding site [chemical binding]; other site 675635003693 oxyanion hole (OAH) forming residues; other site 675635003694 trimer interface [polypeptide binding]; other site 675635003695 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635003696 substrate binding site [chemical binding]; other site 675635003697 trimer interface [polypeptide binding]; other site 675635003698 oxyanion hole (OAH) forming residues; other site 675635003699 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 675635003700 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635003701 acyl-activating enzyme (AAE) consensus motif; other site 675635003702 AMP binding site [chemical binding]; other site 675635003703 active site 675635003704 CoA binding site [chemical binding]; other site 675635003705 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 675635003706 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 675635003707 NAD binding site [chemical binding]; other site 675635003708 catalytic Zn binding site [ion binding]; other site 675635003709 substrate binding site [chemical binding]; other site 675635003710 structural Zn binding site [ion binding]; other site 675635003711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635003712 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 675635003713 Walker A motif; other site 675635003714 ATP binding site [chemical binding]; other site 675635003715 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635003716 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 675635003717 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 675635003718 D-pathway; other site 675635003719 Putative ubiquinol binding site [chemical binding]; other site 675635003720 Low-spin heme (heme b) binding site [chemical binding]; other site 675635003721 Putative water exit pathway; other site 675635003722 Binuclear center (heme o3/CuB) [ion binding]; other site 675635003723 K-pathway; other site 675635003724 Putative proton exit pathway; other site 675635003725 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 675635003726 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 675635003727 phosphoserine phosphatase SerB; Region: serB; TIGR00338 675635003728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635003729 motif II; other site 675635003730 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 675635003731 dimer interface [polypeptide binding]; other site 675635003732 putative active site [active] 675635003733 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 675635003734 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 675635003735 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635003736 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 675635003737 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 675635003738 conserved cys residue [active] 675635003739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635003740 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 675635003741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 675635003742 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 675635003743 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635003744 active site 2 [active] 675635003745 active site 1 [active] 675635003746 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635003747 active site 2 [active] 675635003748 active site 1 [active] 675635003749 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 675635003750 Isochorismatase family; Region: Isochorismatase; pfam00857 675635003751 catalytic triad [active] 675635003752 metal binding site [ion binding]; metal-binding site 675635003753 conserved cis-peptide bond; other site 675635003754 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 675635003755 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 675635003756 active site 675635003757 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 675635003758 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 675635003759 Rdx family; Region: Rdx; cl01407 675635003760 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 675635003761 MPN+ (JAMM) motif; other site 675635003762 Zinc-binding site [ion binding]; other site 675635003763 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 675635003764 MoaE interaction surface [polypeptide binding]; other site 675635003765 MoeB interaction surface [polypeptide binding]; other site 675635003766 thiocarboxylated glycine; other site 675635003767 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 675635003768 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 675635003769 dimer interface [polypeptide binding]; other site 675635003770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635003771 catalytic residue [active] 675635003772 Rhomboid family; Region: Rhomboid; pfam01694 675635003773 glutamate racemase; Provisional; Region: PRK00865 675635003774 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635003775 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635003776 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635003777 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 675635003778 ribonuclease PH; Reviewed; Region: rph; PRK00173 675635003779 Ribonuclease PH; Region: RNase_PH_bact; cd11362 675635003780 hexamer interface [polypeptide binding]; other site 675635003781 active site 675635003782 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 675635003783 active site 675635003784 dimerization interface [polypeptide binding]; other site 675635003785 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635003786 Uncharacterized conserved protein [Function unknown]; Region: COG0398 675635003787 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 675635003788 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 675635003789 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 675635003790 catalytic triad [active] 675635003791 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 675635003792 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 675635003793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003794 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 675635003795 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635003796 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635003797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635003798 DNA binding residues [nucleotide binding] 675635003799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635003800 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635003801 Transcription factor WhiB; Region: Whib; pfam02467 675635003802 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635003803 anti sigma factor interaction site; other site 675635003804 regulatory phosphorylation site [posttranslational modification]; other site 675635003805 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 675635003806 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 675635003807 G1 box; other site 675635003808 putative GEF interaction site [polypeptide binding]; other site 675635003809 GTP/Mg2+ binding site [chemical binding]; other site 675635003810 Switch I region; other site 675635003811 G2 box; other site 675635003812 G3 box; other site 675635003813 Switch II region; other site 675635003814 G4 box; other site 675635003815 G5 box; other site 675635003816 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 675635003817 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 675635003818 selenocysteine synthase; Provisional; Region: PRK04311 675635003819 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 675635003820 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635003821 selenophosphate synthetase; Provisional; Region: PRK00943 675635003822 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 675635003823 dimerization interface [polypeptide binding]; other site 675635003824 putative ATP binding site [chemical binding]; other site 675635003825 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635003826 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 675635003827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635003828 S-adenosylmethionine binding site [chemical binding]; other site 675635003829 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635003830 Amidase; Region: Amidase; cl11426 675635003831 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635003832 anti sigma factor interaction site; other site 675635003833 regulatory phosphorylation site [posttranslational modification]; other site 675635003834 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635003835 dinuclear metal binding motif [ion binding]; other site 675635003836 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635003837 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 675635003838 Walker A/P-loop; other site 675635003839 ATP binding site [chemical binding]; other site 675635003840 Q-loop/lid; other site 675635003841 ABC transporter signature motif; other site 675635003842 Walker B; other site 675635003843 D-loop; other site 675635003844 H-loop/switch region; other site 675635003845 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 675635003846 Histidine kinase; Region: HisKA_3; pfam07730 675635003847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635003848 ATP binding site [chemical binding]; other site 675635003849 Mg2+ binding site [ion binding]; other site 675635003850 G-X-G motif; other site 675635003851 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635003852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635003853 DNA-binding site [nucleotide binding]; DNA binding site 675635003854 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 675635003855 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635003856 classical (c) SDRs; Region: SDR_c; cd05233 675635003857 NAD(P) binding site [chemical binding]; other site 675635003858 active site 675635003859 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 675635003860 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635003861 carboxyltransferase (CT) interaction site; other site 675635003862 biotinylation site [posttranslational modification]; other site 675635003863 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635003864 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635003865 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635003866 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 675635003867 oxaloacetate decarboxylase; Provisional; Region: PRK14041 675635003868 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 675635003869 active site 675635003870 catalytic residues [active] 675635003871 metal binding site [ion binding]; metal-binding site 675635003872 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 675635003873 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635003874 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635003875 acyl-activating enzyme (AAE) consensus motif; other site 675635003876 AMP binding site [chemical binding]; other site 675635003877 active site 675635003878 CoA binding site [chemical binding]; other site 675635003879 pyruvate phosphate dikinase; Provisional; Region: PRK05878 675635003880 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 675635003881 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 675635003882 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635003883 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 675635003884 dimer interface [polypeptide binding]; other site 675635003885 active site 675635003886 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 675635003887 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 675635003888 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635003889 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 675635003890 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635003891 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 675635003892 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 675635003893 active site 675635003894 FMN binding site [chemical binding]; other site 675635003895 2,4-decadienoyl-CoA binding site; other site 675635003896 catalytic residue [active] 675635003897 4Fe-4S cluster binding site [ion binding]; other site 675635003898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635003899 Predicted transcriptional regulators [Transcription]; Region: COG1733 675635003900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635003901 dimerization interface [polypeptide binding]; other site 675635003902 putative DNA binding site [nucleotide binding]; other site 675635003903 putative Zn2+ binding site [ion binding]; other site 675635003904 CCC1-related family of proteins; Region: CCC1_like; cl00278 675635003905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635003906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635003907 active site 675635003908 phosphorylation site [posttranslational modification] 675635003909 intermolecular recognition site; other site 675635003910 dimerization interface [polypeptide binding]; other site 675635003911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635003912 DNA binding residues [nucleotide binding] 675635003913 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635003914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635003915 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635003916 competence damage-inducible protein A; Provisional; Region: PRK00549 675635003917 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 675635003918 Competence-damaged protein; Region: CinA; pfam02464 675635003919 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635003920 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635003921 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635003922 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 675635003923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 675635003924 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 675635003925 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 675635003926 heterodimer interface [polypeptide binding]; other site 675635003927 multimer interface [polypeptide binding]; other site 675635003928 active site 675635003929 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 675635003930 heterodimer interface [polypeptide binding]; other site 675635003931 active site 675635003932 Predicted membrane protein [Function unknown]; Region: COG2246 675635003933 GtrA-like protein; Region: GtrA; pfam04138 675635003934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635003935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635003936 short chain dehydrogenase; Provisional; Region: PRK06197 675635003937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635003938 NAD(P) binding site [chemical binding]; other site 675635003939 active site 675635003940 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 675635003941 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 675635003942 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 675635003943 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635003944 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 675635003945 putative dimer interface [polypeptide binding]; other site 675635003946 N-terminal domain interface [polypeptide binding]; other site 675635003947 putative substrate binding pocket (H-site) [chemical binding]; other site 675635003948 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 675635003949 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 675635003950 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 675635003951 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635003952 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635003953 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 675635003954 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635003955 carboxyltransferase (CT) interaction site; other site 675635003956 biotinylation site [posttranslational modification]; other site 675635003957 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 675635003958 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 675635003959 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635003960 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 675635003961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635003962 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635003963 active site 675635003964 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635003965 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635003966 active site 675635003967 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635003968 hydrophobic ligand binding site; other site 675635003969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635003970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635003971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635003972 putative substrate translocation pore; other site 675635003973 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635003974 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 675635003975 6-phosphofructokinase; Region: PLN02884 675635003976 active site 675635003977 ADP/pyrophosphate binding site [chemical binding]; other site 675635003978 dimerization interface [polypeptide binding]; other site 675635003979 allosteric effector site; other site 675635003980 fructose-1,6-bisphosphate binding site; other site 675635003981 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 675635003982 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635003983 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635003984 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 675635003985 Membrane protein of unknown function; Region: DUF360; pfam04020 675635003986 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 675635003987 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 675635003988 acyl-activating enzyme (AAE) consensus motif; other site 675635003989 putative AMP binding site [chemical binding]; other site 675635003990 putative active site [active] 675635003991 putative CoA binding site [chemical binding]; other site 675635003992 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 675635003993 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635003994 E3 Ubiquitin ligase; Region: GIDE; pfam12483 675635003995 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635003996 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635003997 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635003998 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 675635003999 protein binding site [polypeptide binding]; other site 675635004000 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 675635004001 Predicted membrane protein [Function unknown]; Region: COG2119 675635004002 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 675635004003 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 675635004004 acyl-CoA synthetase; Validated; Region: PRK08316 675635004005 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635004006 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635004007 acyl-activating enzyme (AAE) consensus motif; other site 675635004008 acyl-activating enzyme (AAE) consensus motif; other site 675635004009 AMP binding site [chemical binding]; other site 675635004010 active site 675635004011 CoA binding site [chemical binding]; other site 675635004012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635004013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635004014 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635004015 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635004016 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635004017 active site 675635004018 acyl-CoA synthetase; Validated; Region: PRK08316 675635004019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635004020 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635004021 acyl-activating enzyme (AAE) consensus motif; other site 675635004022 putative AMP binding site [chemical binding]; other site 675635004023 putative active site [active] 675635004024 putative CoA binding site [chemical binding]; other site 675635004025 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 675635004026 Phosphotransferase enzyme family; Region: APH; pfam01636 675635004027 putative active site [active] 675635004028 putative substrate binding site [chemical binding]; other site 675635004029 ATP binding site [chemical binding]; other site 675635004030 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 675635004031 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 675635004032 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 675635004033 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635004034 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635004035 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 675635004036 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635004037 carboxyltransferase (CT) interaction site; other site 675635004038 biotinylation site [posttranslational modification]; other site 675635004039 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635004040 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635004041 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635004042 acyl-activating enzyme (AAE) consensus motif; other site 675635004043 putative AMP binding site [chemical binding]; other site 675635004044 putative active site [active] 675635004045 acyl-activating enzyme (AAE) consensus motif; other site 675635004046 putative CoA binding site [chemical binding]; other site 675635004047 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635004048 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635004049 substrate binding site [chemical binding]; other site 675635004050 oxyanion hole (OAH) forming residues; other site 675635004051 trimer interface [polypeptide binding]; other site 675635004052 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635004053 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635004054 acyl-activating enzyme (AAE) consensus motif; other site 675635004055 AMP binding site [chemical binding]; other site 675635004056 active site 675635004057 CoA binding site [chemical binding]; other site 675635004058 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635004059 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635004060 substrate binding site [chemical binding]; other site 675635004061 oxyanion hole (OAH) forming residues; other site 675635004062 trimer interface [polypeptide binding]; other site 675635004063 TIGR03084 family protein; Region: TIGR03084 675635004064 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 675635004065 Wyosine base formation; Region: Wyosine_form; pfam08608 675635004066 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 675635004067 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 675635004068 AAA domain; Region: AAA_17; pfam13207 675635004069 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635004070 TAP-like protein; Region: Abhydrolase_4; pfam08386 675635004071 flavoprotein, HI0933 family; Region: TIGR00275 675635004072 Transcriptional regulator [Transcription]; Region: LytR; COG1316 675635004073 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635004074 AIR carboxylase; Region: AIRC; smart01001 675635004075 Protein of unknown function DUF111; Region: DUF111; cl03398 675635004076 OsmC-like protein; Region: OsmC; pfam02566 675635004077 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 675635004078 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 675635004079 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 675635004080 tetramer interface [polypeptide binding]; other site 675635004081 active site 675635004082 D-cysteine desulfhydrase; Validated; Region: PRK03910 675635004083 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 675635004084 catalytic residue [active] 675635004085 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 675635004086 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 675635004087 tetramer interface [polypeptide binding]; other site 675635004088 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 675635004089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635004090 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635004091 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 675635004092 intersubunit interface [polypeptide binding]; other site 675635004093 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 675635004094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 675635004095 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 675635004096 Bacterial transcriptional activator domain; Region: BTAD; smart01043 675635004097 AAA ATPase domain; Region: AAA_16; pfam13191 675635004098 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 675635004099 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635004100 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635004101 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635004102 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635004103 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 675635004104 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635004105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635004106 putative DNA binding site [nucleotide binding]; other site 675635004107 putative Zn2+ binding site [ion binding]; other site 675635004108 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 675635004109 DNA binding site [nucleotide binding] 675635004110 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635004111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635004112 active site 675635004113 phosphorylation site [posttranslational modification] 675635004114 intermolecular recognition site; other site 675635004115 dimerization interface [polypeptide binding]; other site 675635004116 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635004117 DNA binding residues [nucleotide binding] 675635004118 dimerization interface [polypeptide binding]; other site 675635004119 Cupin domain; Region: Cupin_2; cl17218 675635004120 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 675635004121 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 675635004122 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635004123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 675635004124 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 675635004125 Sulphur transport; Region: Sulf_transp; pfam04143 675635004126 phosphofructokinase; Region: PFK_mixed; TIGR02483 675635004127 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 675635004128 active site 675635004129 ADP/pyrophosphate binding site [chemical binding]; other site 675635004130 dimerization interface [polypeptide binding]; other site 675635004131 allosteric effector site; other site 675635004132 fructose-1,6-bisphosphate binding site; other site 675635004133 Clp protease; Region: CLP_protease; pfam00574 675635004134 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 675635004135 oligomer interface [polypeptide binding]; other site 675635004136 active site residues [active] 675635004137 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 675635004138 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635004139 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635004140 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 675635004141 Repair protein; Region: Repair_PSII; pfam04536 675635004142 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 675635004143 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 675635004144 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 675635004145 putative [4Fe-4S] binding site [ion binding]; other site 675635004146 putative molybdopterin cofactor binding site [chemical binding]; other site 675635004147 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 675635004148 molybdopterin cofactor binding site; other site 675635004149 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 675635004150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635004151 Domain of unknown function (DUF305); Region: DUF305; pfam03713 675635004152 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 675635004153 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 675635004154 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 675635004155 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 675635004156 active site 675635004157 HIGH motif; other site 675635004158 KMSK motif region; other site 675635004159 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 675635004160 tRNA binding surface [nucleotide binding]; other site 675635004161 anticodon binding site; other site 675635004162 diaminopimelate decarboxylase; Region: lysA; TIGR01048 675635004163 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 675635004164 active site 675635004165 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635004166 substrate binding site [chemical binding]; other site 675635004167 catalytic residues [active] 675635004168 dimer interface [polypeptide binding]; other site 675635004169 homoserine dehydrogenase; Provisional; Region: PRK06349 675635004170 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 675635004171 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 675635004172 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 675635004173 threonine synthase; Reviewed; Region: PRK06721 675635004174 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 675635004175 homodimer interface [polypeptide binding]; other site 675635004176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635004177 catalytic residue [active] 675635004178 homoserine kinase; Provisional; Region: PRK01212 675635004179 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 675635004180 transcription termination factor Rho; Provisional; Region: PRK12608 675635004181 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 675635004182 RNA binding site [nucleotide binding]; other site 675635004183 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 675635004184 multimer interface [polypeptide binding]; other site 675635004185 Walker A motif; other site 675635004186 ATP binding site [chemical binding]; other site 675635004187 Walker B motif; other site 675635004188 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 675635004189 peptide chain release factor 1; Validated; Region: prfA; PRK00591 675635004190 PCRF domain; Region: PCRF; pfam03462 675635004191 RF-1 domain; Region: RF-1; pfam00472 675635004192 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 675635004193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635004194 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 675635004195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635004196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635004197 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 675635004198 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 675635004199 dimer interface [polypeptide binding]; other site 675635004200 active site 675635004201 glycine-pyridoxal phosphate binding site [chemical binding]; other site 675635004202 folate binding site [chemical binding]; other site 675635004203 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 675635004204 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 675635004205 Mg++ binding site [ion binding]; other site 675635004206 putative catalytic motif [active] 675635004207 substrate binding site [chemical binding]; other site 675635004208 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 675635004209 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 675635004210 ATP synthase subunit C; Region: ATP-synt_C; cl00466 675635004211 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 675635004212 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 675635004213 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 675635004214 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 675635004215 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 675635004216 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 675635004217 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 675635004218 beta subunit interaction interface [polypeptide binding]; other site 675635004219 Walker A motif; other site 675635004220 ATP binding site [chemical binding]; other site 675635004221 Walker B motif; other site 675635004222 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 675635004223 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 675635004224 core domain interface [polypeptide binding]; other site 675635004225 delta subunit interface [polypeptide binding]; other site 675635004226 epsilon subunit interface [polypeptide binding]; other site 675635004227 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 675635004228 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 675635004229 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 675635004230 alpha subunit interaction interface [polypeptide binding]; other site 675635004231 Walker A motif; other site 675635004232 ATP binding site [chemical binding]; other site 675635004233 Walker B motif; other site 675635004234 inhibitor binding site; inhibition site 675635004235 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 675635004236 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 675635004237 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 675635004238 gamma subunit interface [polypeptide binding]; other site 675635004239 epsilon subunit interface [polypeptide binding]; other site 675635004240 LBP interface [polypeptide binding]; other site 675635004241 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 675635004242 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 675635004243 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 675635004244 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 675635004245 hinge; other site 675635004246 active site 675635004247 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 675635004248 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 675635004249 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 675635004250 B12 binding site [chemical binding]; other site 675635004251 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 675635004252 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 675635004253 substrate binding pocket [chemical binding]; other site 675635004254 membrane-bound complex binding site; other site 675635004255 hinge residues; other site 675635004256 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 675635004257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635004258 dimer interface [polypeptide binding]; other site 675635004259 conserved gate region; other site 675635004260 putative PBP binding loops; other site 675635004261 ABC-ATPase subunit interface; other site 675635004262 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 675635004263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635004264 ABC-ATPase subunit interface; other site 675635004265 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 675635004266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635004267 Walker A/P-loop; other site 675635004268 ATP binding site [chemical binding]; other site 675635004269 Q-loop/lid; other site 675635004270 ABC transporter signature motif; other site 675635004271 Walker B; other site 675635004272 D-loop; other site 675635004273 H-loop/switch region; other site 675635004274 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 675635004275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 675635004276 substrate binding pocket [chemical binding]; other site 675635004277 membrane-bound complex binding site; other site 675635004278 enoyl-CoA hydratase; Validated; Region: PRK08139 675635004279 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635004280 substrate binding site [chemical binding]; other site 675635004281 oxyanion hole (OAH) forming residues; other site 675635004282 trimer interface [polypeptide binding]; other site 675635004283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635004284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635004285 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635004286 Cytochrome P450; Region: p450; cl12078 675635004287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635004288 S-adenosylmethionine binding site [chemical binding]; other site 675635004289 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635004290 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635004291 active site 675635004292 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 675635004293 dimer interface [polypeptide binding]; other site 675635004294 active site 675635004295 ADP-ribose binding site [chemical binding]; other site 675635004296 nudix motif; other site 675635004297 metal binding site [ion binding]; metal-binding site 675635004298 HTH domain; Region: HTH_11; pfam08279 675635004299 WYL domain; Region: WYL; pfam13280 675635004300 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635004301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635004302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635004303 active site 675635004304 AAA ATPase domain; Region: AAA_16; pfam13191 675635004305 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635004306 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635004307 DNA binding residues [nucleotide binding] 675635004308 dimerization interface [polypeptide binding]; other site 675635004309 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 675635004310 hypothetical protein; Provisional; Region: PRK03298 675635004311 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635004312 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 675635004313 tetramer interface [polypeptide binding]; other site 675635004314 catalytic Zn binding site [ion binding]; other site 675635004315 NADP binding site [chemical binding]; other site 675635004316 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635004317 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 675635004318 NAD(P) binding site [chemical binding]; other site 675635004319 catalytic residues [active] 675635004320 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 675635004321 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 675635004322 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 675635004323 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 675635004324 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 675635004325 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 675635004326 cell division protein GpsB; Provisional; Region: PRK14127 675635004327 DivIVA domain; Region: DivI1A_domain; TIGR03544 675635004328 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635004329 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 675635004330 NAD(P) binding site [chemical binding]; other site 675635004331 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 675635004332 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635004333 dimer interface [polypeptide binding]; other site 675635004334 substrate binding site [chemical binding]; other site 675635004335 metal binding site [ion binding]; metal-binding site 675635004336 putative acyltransferase; Provisional; Region: PRK05790 675635004337 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635004338 dimer interface [polypeptide binding]; other site 675635004339 active site 675635004340 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 675635004341 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 675635004342 Walker A; other site 675635004343 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 675635004344 G5 box; other site 675635004345 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635004346 MarR family; Region: MarR_2; pfam12802 675635004347 MarR family; Region: MarR_2; cl17246 675635004348 Domain of unknown function DUF77; Region: DUF77; pfam01910 675635004349 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635004350 Helix-turn-helix domain; Region: HTH_38; pfam13936 675635004351 Integrase core domain; Region: rve; pfam00665 675635004352 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 675635004353 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 675635004354 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 675635004355 glycogen branching enzyme; Provisional; Region: PRK05402 675635004356 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 675635004357 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 675635004358 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 675635004359 active site 675635004360 catalytic site [active] 675635004361 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 675635004362 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 675635004363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635004364 MgtE intracellular N domain; Region: MgtE_N; cl15244 675635004365 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635004366 DNA binding residues [nucleotide binding] 675635004367 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 675635004368 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 675635004369 trehalose synthase; Region: treS_nterm; TIGR02456 675635004370 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 675635004371 active site 675635004372 catalytic site [active] 675635004373 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 675635004374 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 675635004375 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 675635004376 active site 675635004377 homodimer interface [polypeptide binding]; other site 675635004378 catalytic site [active] 675635004379 acceptor binding site [chemical binding]; other site 675635004380 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 675635004381 putative homodimer interface [polypeptide binding]; other site 675635004382 putative active site pocket [active] 675635004383 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 675635004384 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 675635004385 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 675635004386 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 675635004387 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 675635004388 active site 675635004389 catalytic site [active] 675635004390 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 675635004391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635004392 Walker A/P-loop; other site 675635004393 ATP binding site [chemical binding]; other site 675635004394 Q-loop/lid; other site 675635004395 ABC transporter signature motif; other site 675635004396 Walker B; other site 675635004397 D-loop; other site 675635004398 H-loop/switch region; other site 675635004399 enoyl-CoA hydratase; Provisional; Region: PRK05862 675635004400 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635004401 substrate binding site [chemical binding]; other site 675635004402 oxyanion hole (OAH) forming residues; other site 675635004403 trimer interface [polypeptide binding]; other site 675635004404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635004405 S-adenosylmethionine binding site [chemical binding]; other site 675635004406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635004407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635004408 ATP binding site [chemical binding]; other site 675635004409 G-X-G motif; other site 675635004410 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635004411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635004412 active site 675635004413 phosphorylation site [posttranslational modification] 675635004414 intermolecular recognition site; other site 675635004415 dimerization interface [polypeptide binding]; other site 675635004416 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635004417 DNA binding residues [nucleotide binding] 675635004418 dimerization interface [polypeptide binding]; other site 675635004419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635004420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635004421 DNA binding residues [nucleotide binding] 675635004422 dimerization interface [polypeptide binding]; other site 675635004423 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 675635004424 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 675635004425 trimer interface [polypeptide binding]; other site 675635004426 active site 675635004427 substrate binding site [chemical binding]; other site 675635004428 CoA binding site [chemical binding]; other site 675635004429 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635004430 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 675635004431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635004432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635004433 dimerization interface [polypeptide binding]; other site 675635004434 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635004435 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635004436 active site 675635004437 non-prolyl cis peptide bond; other site 675635004438 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 675635004439 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635004440 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635004441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635004442 ABC-ATPase subunit interface; other site 675635004443 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635004444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635004445 dimer interface [polypeptide binding]; other site 675635004446 conserved gate region; other site 675635004447 putative PBP binding loops; other site 675635004448 ABC-ATPase subunit interface; other site 675635004449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635004450 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 675635004451 Walker A/P-loop; other site 675635004452 ATP binding site [chemical binding]; other site 675635004453 Q-loop/lid; other site 675635004454 ABC transporter signature motif; other site 675635004455 Walker B; other site 675635004456 D-loop; other site 675635004457 H-loop/switch region; other site 675635004458 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635004459 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 675635004460 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635004461 Walker A/P-loop; other site 675635004462 ATP binding site [chemical binding]; other site 675635004463 Q-loop/lid; other site 675635004464 ABC transporter signature motif; other site 675635004465 Walker B; other site 675635004466 D-loop; other site 675635004467 H-loop/switch region; other site 675635004468 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 675635004469 Cupin domain; Region: Cupin_2; cl17218 675635004470 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 675635004471 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635004472 Uncharacterized conserved protein [Function unknown]; Region: COG1543 675635004473 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 675635004474 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 675635004475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635004476 S-adenosylmethionine binding site [chemical binding]; other site 675635004477 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635004478 allantoicase; Provisional; Region: PRK13257 675635004479 Allantoicase repeat; Region: Allantoicase; pfam03561 675635004480 Allantoicase repeat; Region: Allantoicase; pfam03561 675635004481 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 675635004482 allantoinase; Region: allantoinase; TIGR03178 675635004483 active site 675635004484 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 675635004485 putative active site pocket [active] 675635004486 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 675635004487 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635004488 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635004489 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 675635004490 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 675635004491 active site 675635004492 putative substrate binding pocket [chemical binding]; other site 675635004493 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635004494 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635004495 catalytic loop [active] 675635004496 iron binding site [ion binding]; other site 675635004497 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635004498 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635004499 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635004500 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 675635004501 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635004502 urate oxidase; Region: urate_oxi; TIGR03383 675635004503 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 675635004504 active site 675635004505 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 675635004506 active site 675635004507 homotetramer interface [polypeptide binding]; other site 675635004508 putative OHCU decarboxylase; Provisional; Region: PRK13798 675635004509 xanthine permease; Region: pbuX; TIGR03173 675635004510 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 675635004511 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 675635004512 Ligand binding site [chemical binding]; other site 675635004513 Electron transfer flavoprotein domain; Region: ETF; pfam01012 675635004514 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 675635004515 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 675635004516 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 675635004517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 675635004518 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 675635004519 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635004520 putative acyl-acceptor binding pocket; other site 675635004521 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 675635004522 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 675635004523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635004524 catalytic residue [active] 675635004525 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 675635004526 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 675635004527 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 675635004528 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635004529 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635004530 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635004531 acyl-activating enzyme (AAE) consensus motif; other site 675635004532 acyl-activating enzyme (AAE) consensus motif; other site 675635004533 putative AMP binding site [chemical binding]; other site 675635004534 putative active site [active] 675635004535 putative CoA binding site [chemical binding]; other site 675635004536 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 675635004537 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635004538 active site 675635004539 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635004540 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635004541 active site 675635004542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635004543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635004544 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 675635004545 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 675635004546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635004547 catalytic residue [active] 675635004548 Clp amino terminal domain; Region: Clp_N; pfam02861 675635004549 Clp amino terminal domain; Region: Clp_N; pfam02861 675635004550 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635004551 Ligase N family; Region: LIGANc; smart00532 675635004552 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 675635004553 nucleotide binding pocket [chemical binding]; other site 675635004554 K-X-D-G motif; other site 675635004555 catalytic site [active] 675635004556 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 675635004557 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 675635004558 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 675635004559 Dimer interface [polypeptide binding]; other site 675635004560 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 675635004561 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 675635004562 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 675635004563 FAD binding pocket [chemical binding]; other site 675635004564 FAD binding motif [chemical binding]; other site 675635004565 phosphate binding motif [ion binding]; other site 675635004566 beta-alpha-beta structure motif; other site 675635004567 NAD binding pocket [chemical binding]; other site 675635004568 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635004569 catalytic loop [active] 675635004570 iron binding site [ion binding]; other site 675635004571 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 675635004572 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 675635004573 putative di-iron ligands [ion binding]; other site 675635004574 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635004575 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 675635004576 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 675635004577 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635004578 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 675635004579 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 675635004580 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 675635004581 GatB domain; Region: GatB_Yqey; smart00845 675635004582 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 675635004583 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635004584 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 675635004585 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 675635004586 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635004587 NAD binding site [chemical binding]; other site 675635004588 catalytic residues [active] 675635004589 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635004590 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635004591 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635004592 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635004593 DNA binding site [nucleotide binding] 675635004594 domain linker motif; other site 675635004595 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 675635004596 dimerization interface [polypeptide binding]; other site 675635004597 ligand binding site [chemical binding]; other site 675635004598 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635004599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635004600 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635004601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635004602 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635004603 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635004604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635004605 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 675635004606 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635004607 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635004608 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635004609 active site 675635004610 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 675635004611 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635004612 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635004613 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 675635004614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004615 NAD(P) binding site [chemical binding]; other site 675635004616 active site 675635004617 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 675635004618 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 675635004619 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 675635004620 putative ligand binding site [chemical binding]; other site 675635004621 putative NAD binding site [chemical binding]; other site 675635004622 catalytic site [active] 675635004623 Predicted membrane protein [Function unknown]; Region: COG2259 675635004624 Phosphotransferase enzyme family; Region: APH; pfam01636 675635004625 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 675635004626 RibD C-terminal domain; Region: RibD_C; cl17279 675635004627 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 675635004628 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 675635004629 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 675635004630 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635004631 PYR/PP interface [polypeptide binding]; other site 675635004632 dimer interface [polypeptide binding]; other site 675635004633 TPP binding site [chemical binding]; other site 675635004634 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 675635004635 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 675635004636 TPP-binding site [chemical binding]; other site 675635004637 dimer interface [polypeptide binding]; other site 675635004638 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 675635004639 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 675635004640 putative valine binding site [chemical binding]; other site 675635004641 dimer interface [polypeptide binding]; other site 675635004642 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 675635004643 ketol-acid reductoisomerase; Provisional; Region: PRK05479 675635004644 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 675635004645 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 675635004646 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 675635004647 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635004648 hypothetical protein; Provisional; Region: PRK08317 675635004649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635004650 S-adenosylmethionine binding site [chemical binding]; other site 675635004651 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 675635004652 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 675635004653 ligand binding site [chemical binding]; other site 675635004654 NAD binding site [chemical binding]; other site 675635004655 dimerization interface [polypeptide binding]; other site 675635004656 catalytic site [active] 675635004657 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 675635004658 putative L-serine binding site [chemical binding]; other site 675635004659 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 675635004660 tartrate dehydrogenase; Region: TTC; TIGR02089 675635004661 EthD domain; Region: EthD; cl17553 675635004662 hypothetical protein; Provisional; Region: PRK06185 675635004663 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 675635004664 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 675635004665 HIGH motif; other site 675635004666 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 675635004667 active site 675635004668 KMSKS motif; other site 675635004669 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 675635004670 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 675635004671 nucleotide binding site [chemical binding]; other site 675635004672 putative NEF/HSP70 interaction site [polypeptide binding]; other site 675635004673 SBD interface [polypeptide binding]; other site 675635004674 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635004675 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635004676 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635004677 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 675635004678 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 675635004679 substrate binding site [chemical binding]; other site 675635004680 ligand binding site [chemical binding]; other site 675635004681 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 675635004682 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 675635004683 substrate binding site [chemical binding]; other site 675635004684 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 675635004685 IHF - DNA interface [nucleotide binding]; other site 675635004686 IHF dimer interface [polypeptide binding]; other site 675635004687 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 675635004688 active site 675635004689 Ap6A binding site [chemical binding]; other site 675635004690 nudix motif; other site 675635004691 metal binding site [ion binding]; metal-binding site 675635004692 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635004693 catalytic core [active] 675635004694 polyphosphate kinase; Provisional; Region: PRK05443 675635004695 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 675635004696 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 675635004697 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 675635004698 putative domain interface [polypeptide binding]; other site 675635004699 putative active site [active] 675635004700 catalytic site [active] 675635004701 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 675635004702 putative domain interface [polypeptide binding]; other site 675635004703 putative active site [active] 675635004704 catalytic site [active] 675635004705 Guanylyl transferase CofC like; Region: CofC; cl17472 675635004706 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 675635004707 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635004708 putative acyl-acceptor binding pocket; other site 675635004709 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 675635004710 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 675635004711 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 675635004712 cystathionine gamma-lyase; Validated; Region: PRK07582 675635004713 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635004714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635004715 catalytic residue [active] 675635004716 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 675635004717 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 675635004718 active site 675635004719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 675635004720 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 675635004721 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 675635004722 Bacterial sugar transferase; Region: Bac_transf; pfam02397 675635004723 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 675635004724 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635004725 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635004726 catalytic residue [active] 675635004727 Chain length determinant protein; Region: Wzz; cl15801 675635004728 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 675635004729 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 675635004730 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 675635004731 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 675635004732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635004733 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 675635004734 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 675635004735 active site 675635004736 dimer interface [polypeptide binding]; other site 675635004737 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 675635004738 Ligand Binding Site [chemical binding]; other site 675635004739 Molecular Tunnel; other site 675635004740 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635004741 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 675635004742 putative NAD(P) binding site [chemical binding]; other site 675635004743 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635004744 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 675635004745 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 675635004746 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 675635004747 Right handed beta helix region; Region: Beta_helix; pfam13229 675635004748 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 675635004749 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635004750 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635004751 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635004752 putative trimer interface [polypeptide binding]; other site 675635004753 putative CoA binding site [chemical binding]; other site 675635004754 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 675635004755 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 675635004756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 675635004757 active site 675635004758 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 675635004759 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 675635004760 active site 675635004761 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 675635004762 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 675635004763 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635004764 active site 675635004765 Repair protein; Region: Repair_PSII; pfam04536 675635004766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635004767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635004768 ATP binding site [chemical binding]; other site 675635004769 Mg2+ binding site [ion binding]; other site 675635004770 G-X-G motif; other site 675635004771 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635004772 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635004773 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635004774 Right handed beta helix region; Region: Beta_helix; pfam13229 675635004775 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635004776 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635004777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635004778 active site 675635004779 phosphorylation site [posttranslational modification] 675635004780 intermolecular recognition site; other site 675635004781 dimerization interface [polypeptide binding]; other site 675635004782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635004783 DNA binding site [nucleotide binding] 675635004784 HAMP domain; Region: HAMP; pfam00672 675635004785 dimerization interface [polypeptide binding]; other site 675635004786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635004787 dimer interface [polypeptide binding]; other site 675635004788 phosphorylation site [posttranslational modification] 675635004789 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635004790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635004791 ATP binding site [chemical binding]; other site 675635004792 Mg2+ binding site [ion binding]; other site 675635004793 G-X-G motif; other site 675635004794 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 675635004795 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 675635004796 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 675635004797 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 675635004798 putative active site [active] 675635004799 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 675635004800 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 675635004801 putative active site [active] 675635004802 putative metal binding site [ion binding]; other site 675635004803 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635004804 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635004805 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 675635004806 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 675635004807 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 675635004808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004809 NAD(P) binding site [chemical binding]; other site 675635004810 active site 675635004811 O-Antigen ligase; Region: Wzy_C; pfam04932 675635004812 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 675635004813 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635004814 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635004815 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 675635004816 Bacterial sugar transferase; Region: Bac_transf; pfam02397 675635004817 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 675635004818 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635004819 Ligand binding site; other site 675635004820 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635004821 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635004822 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 675635004823 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 675635004824 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 675635004825 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 675635004826 putative active site [active] 675635004827 putative metal binding site [ion binding]; other site 675635004828 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 675635004829 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 675635004830 active site 675635004831 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635004832 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 675635004833 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 675635004834 putative trimer interface [polypeptide binding]; other site 675635004835 putative active site [active] 675635004836 putative substrate binding site [chemical binding]; other site 675635004837 putative CoA binding site [chemical binding]; other site 675635004838 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 675635004839 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 675635004840 inhibitor-cofactor binding pocket; inhibition site 675635004841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635004842 catalytic residue [active] 675635004843 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 675635004844 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 675635004845 inhibitor-cofactor binding pocket; inhibition site 675635004846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635004847 catalytic residue [active] 675635004848 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635004849 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 675635004850 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635004851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635004852 NAD(P) binding site [chemical binding]; other site 675635004853 active site 675635004854 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 675635004855 active site 675635004856 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 675635004857 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 675635004858 Zn binding site [ion binding]; other site 675635004859 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 675635004860 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 675635004861 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 675635004862 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635004863 extended (e) SDRs; Region: SDR_e; cd08946 675635004864 NAD(P) binding site [chemical binding]; other site 675635004865 active site 675635004866 substrate binding site [chemical binding]; other site 675635004867 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635004868 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 675635004869 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635004870 Methyltransferase domain; Region: Methyltransf_12; pfam08242 675635004871 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 675635004872 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 675635004873 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635004874 FOG: CBS domain [General function prediction only]; Region: COG0517 675635004875 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 675635004876 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 675635004877 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635004878 NAD binding site [chemical binding]; other site 675635004879 catalytic residues [active] 675635004880 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635004881 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635004882 active site 675635004883 ATP binding site [chemical binding]; other site 675635004884 substrate binding site [chemical binding]; other site 675635004885 activation loop (A-loop); other site 675635004886 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 675635004887 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 675635004888 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635004889 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 675635004890 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 675635004891 active site 675635004892 dimer interface [polypeptide binding]; other site 675635004893 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 675635004894 Ligand Binding Site [chemical binding]; other site 675635004895 Molecular Tunnel; other site 675635004896 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 675635004897 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 675635004898 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 675635004899 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 675635004900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635004901 motif II; other site 675635004902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635004903 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 675635004904 Protein of unknown function (DUF429); Region: DUF429; cl12046 675635004905 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 675635004906 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 675635004907 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 675635004908 putative DNA binding site [nucleotide binding]; other site 675635004909 catalytic residue [active] 675635004910 putative H2TH interface [polypeptide binding]; other site 675635004911 putative catalytic residues [active] 675635004912 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 675635004913 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 675635004914 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 675635004915 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 675635004916 RNA polymerase factor sigma-70; Validated; Region: PRK08241 675635004917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635004918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635004919 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635004920 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 675635004921 hypothetical protein; Provisional; Region: PRK06208 675635004922 intersubunit interface [polypeptide binding]; other site 675635004923 active site 675635004924 Zn2+ binding site [ion binding]; other site 675635004925 Cupin domain; Region: Cupin_2; cl17218 675635004926 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 675635004927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635004928 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 675635004929 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 675635004930 active site 675635004931 HIGH motif; other site 675635004932 dimer interface [polypeptide binding]; other site 675635004933 KMSKS motif; other site 675635004934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635004935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635004936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635004937 dimerization interface [polypeptide binding]; other site 675635004938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 675635004939 RibD C-terminal domain; Region: RibD_C; cl17279 675635004940 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635004941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635004942 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 675635004943 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635004944 Walker A/P-loop; other site 675635004945 ATP binding site [chemical binding]; other site 675635004946 Q-loop/lid; other site 675635004947 ABC transporter signature motif; other site 675635004948 Walker B; other site 675635004949 D-loop; other site 675635004950 H-loop/switch region; other site 675635004951 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 675635004952 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 675635004953 FtsX-like permease family; Region: FtsX; pfam02687 675635004954 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635004955 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635004956 putative NAD(P) binding site [chemical binding]; other site 675635004957 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635004958 Zn2+ binding site [ion binding]; other site 675635004959 Mg2+ binding site [ion binding]; other site 675635004960 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 675635004961 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 675635004962 conserved cys residue [active] 675635004963 Uncharacterized conserved protein [Function unknown]; Region: COG4850 675635004964 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 675635004965 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 675635004966 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 675635004967 homodimer interface [polypeptide binding]; other site 675635004968 active site 675635004969 TDP-binding site; other site 675635004970 acceptor substrate-binding pocket; other site 675635004971 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 675635004972 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 675635004973 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 675635004974 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635004975 Domain of unknown function (DUF385); Region: DUF385; cl04387 675635004976 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 675635004977 Cation efflux family; Region: Cation_efflux; pfam01545 675635004978 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 675635004979 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 675635004980 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 675635004981 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 675635004982 active site 675635004983 dimer interface [polypeptide binding]; other site 675635004984 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 675635004985 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 675635004986 active site 675635004987 FMN binding site [chemical binding]; other site 675635004988 substrate binding site [chemical binding]; other site 675635004989 3Fe-4S cluster binding site [ion binding]; other site 675635004990 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 675635004991 domain interface; other site 675635004992 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 675635004993 Asp23 family; Region: Asp23; cl00574 675635004994 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 675635004995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635004996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635004997 DNA binding residues [nucleotide binding] 675635004998 CsbD-like; Region: CsbD; pfam05532 675635004999 trigger factor; Provisional; Region: tig; PRK01490 675635005000 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 675635005001 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 675635005002 Clp protease; Region: CLP_protease; pfam00574 675635005003 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 675635005004 oligomer interface [polypeptide binding]; other site 675635005005 active site residues [active] 675635005006 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 675635005007 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 675635005008 oligomer interface [polypeptide binding]; other site 675635005009 active site residues [active] 675635005010 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 675635005011 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 675635005012 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 675635005013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635005014 Walker A motif; other site 675635005015 ATP binding site [chemical binding]; other site 675635005016 Walker B motif; other site 675635005017 arginine finger; other site 675635005018 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 675635005019 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635005020 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635005021 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 675635005022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635005023 putative substrate translocation pore; other site 675635005024 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 675635005025 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 675635005026 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635005027 active site 675635005028 HIGH motif; other site 675635005029 nucleotide binding site [chemical binding]; other site 675635005030 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 675635005031 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 675635005032 active site 675635005033 KMSKS motif; other site 675635005034 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 675635005035 tRNA binding surface [nucleotide binding]; other site 675635005036 anticodon binding site; other site 675635005037 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 675635005038 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 675635005039 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635005040 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 675635005041 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 675635005042 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 675635005043 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 675635005044 active site 675635005045 multimer interface [polypeptide binding]; other site 675635005046 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635005047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635005048 Walker A/P-loop; other site 675635005049 ATP binding site [chemical binding]; other site 675635005050 Q-loop/lid; other site 675635005051 ABC transporter signature motif; other site 675635005052 Walker B; other site 675635005053 D-loop; other site 675635005054 H-loop/switch region; other site 675635005055 ABC-2 type transporter; Region: ABC2_membrane; cl17235 675635005056 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 675635005057 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 675635005058 ABC-2 type transporter; Region: ABC2_membrane; cl17235 675635005059 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 675635005060 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 675635005061 dihydrodipicolinate synthase; Region: dapA; TIGR00674 675635005062 dimer interface [polypeptide binding]; other site 675635005063 active site 675635005064 catalytic residue [active] 675635005065 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 675635005066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635005067 FeS/SAM binding site; other site 675635005068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 675635005069 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 675635005070 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 675635005071 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 675635005072 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 675635005073 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 675635005074 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 675635005075 homodimer interface [polypeptide binding]; other site 675635005076 oligonucleotide binding site [chemical binding]; other site 675635005077 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 675635005078 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 675635005079 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 675635005080 GTPase CgtA; Reviewed; Region: obgE; PRK12296 675635005081 GTP1/OBG; Region: GTP1_OBG; pfam01018 675635005082 Obg GTPase; Region: Obg; cd01898 675635005083 G1 box; other site 675635005084 GTP/Mg2+ binding site [chemical binding]; other site 675635005085 Switch I region; other site 675635005086 G2 box; other site 675635005087 G3 box; other site 675635005088 Switch II region; other site 675635005089 G4 box; other site 675635005090 G5 box; other site 675635005091 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 675635005092 gamma-glutamyl kinase; Provisional; Region: PRK05429 675635005093 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 675635005094 nucleotide binding site [chemical binding]; other site 675635005095 homotetrameric interface [polypeptide binding]; other site 675635005096 putative phosphate binding site [ion binding]; other site 675635005097 putative allosteric binding site; other site 675635005098 PUA domain; Region: PUA; pfam01472 675635005099 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); Region: PCMT; pfam01135 675635005100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635005101 S-adenosylmethionine binding site [chemical binding]; other site 675635005102 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 675635005103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635005104 ATP binding site [chemical binding]; other site 675635005105 putative Mg++ binding site [ion binding]; other site 675635005106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635005107 nucleotide binding region [chemical binding]; other site 675635005108 ATP-binding site [chemical binding]; other site 675635005109 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 675635005110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635005111 Walker A motif; other site 675635005112 ATP binding site [chemical binding]; other site 675635005113 Walker B motif; other site 675635005114 arginine finger; other site 675635005115 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 675635005116 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635005117 putative Zn2+ binding site [ion binding]; other site 675635005118 putative DNA binding site [nucleotide binding]; other site 675635005119 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635005120 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 675635005121 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635005122 AAA ATPase domain; Region: AAA_16; pfam13191 675635005123 Hemerythrin-like domain; Region: Hr-like; cd12108 675635005124 Fe binding site [ion binding]; other site 675635005125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635005126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635005127 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 675635005128 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 675635005129 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 675635005130 active site 675635005131 (T/H)XGH motif; other site 675635005132 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 675635005133 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635005134 catalytic core [active] 675635005135 EDD domain protein, DegV family; Region: DegV; TIGR00762 675635005136 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 675635005137 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 675635005138 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 675635005139 threonine synthase; Validated; Region: PRK07591 675635005140 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 675635005141 homodimer interface [polypeptide binding]; other site 675635005142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635005143 catalytic residue [active] 675635005144 hypothetical protein; Reviewed; Region: PRK07914 675635005145 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 675635005146 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 675635005147 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635005148 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635005149 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 675635005150 NHL repeat; Region: NHL; pfam01436 675635005151 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 675635005152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635005153 Walker A/P-loop; other site 675635005154 ATP binding site [chemical binding]; other site 675635005155 Q-loop/lid; other site 675635005156 ABC transporter signature motif; other site 675635005157 Walker B; other site 675635005158 D-loop; other site 675635005159 H-loop/switch region; other site 675635005160 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 675635005161 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 675635005162 DNA binding site [nucleotide binding] 675635005163 catalytic residue [active] 675635005164 H2TH interface [polypeptide binding]; other site 675635005165 putative catalytic residues [active] 675635005166 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 675635005167 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 675635005168 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 675635005169 active site 675635005170 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 675635005171 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 675635005172 active site 675635005173 dimer interface [polypeptide binding]; other site 675635005174 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 675635005175 dimer interface [polypeptide binding]; other site 675635005176 active site 675635005177 Predicted membrane protein [Function unknown]; Region: COG2259 675635005178 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 675635005179 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 675635005180 Phosphotransferase enzyme family; Region: APH; pfam01636 675635005181 putative active site [active] 675635005182 putative substrate binding site [chemical binding]; other site 675635005183 ATP binding site [chemical binding]; other site 675635005184 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635005185 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635005186 catalytic residue [active] 675635005187 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 675635005188 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 675635005189 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 675635005190 NodB motif; other site 675635005191 active site 675635005192 catalytic site [active] 675635005193 metal binding site [ion binding]; metal-binding site 675635005194 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635005195 Cytochrome P450; Region: p450; cl12078 675635005196 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 675635005197 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 675635005198 active site 675635005199 metal binding site [ion binding]; metal-binding site 675635005200 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 675635005201 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 675635005202 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 675635005203 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 675635005204 siderophore binding site; other site 675635005205 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 675635005206 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 675635005207 Cl- selectivity filter; other site 675635005208 Cl- binding residues [ion binding]; other site 675635005209 pore gating glutamate residue; other site 675635005210 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 675635005211 Beta-lactamase; Region: Beta-lactamase; pfam00144 675635005212 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 675635005213 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 675635005214 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635005215 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635005216 DNA binding residues [nucleotide binding] 675635005217 Putative zinc-finger; Region: zf-HC2; pfam13490 675635005218 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 675635005219 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635005220 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 675635005221 putative hydrophobic ligand binding site [chemical binding]; other site 675635005222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635005223 dimerization interface [polypeptide binding]; other site 675635005224 putative DNA binding site [nucleotide binding]; other site 675635005225 putative Zn2+ binding site [ion binding]; other site 675635005226 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 675635005227 amphipathic channel; other site 675635005228 Asn-Pro-Ala signature motifs; other site 675635005229 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635005230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635005231 catalytic residue [active] 675635005232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635005233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635005234 putative substrate translocation pore; other site 675635005235 Predicted acyl esterases [General function prediction only]; Region: COG2936 675635005236 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 675635005237 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 675635005238 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 675635005239 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 675635005240 putative DNA binding site [nucleotide binding]; other site 675635005241 putative homodimer interface [polypeptide binding]; other site 675635005242 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 675635005243 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635005244 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635005245 active site 675635005246 non-prolyl cis peptide bond; other site 675635005247 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 675635005248 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635005249 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635005250 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635005251 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635005252 DNA binding site [nucleotide binding] 675635005253 domain linker motif; other site 675635005254 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 675635005255 ligand binding site [chemical binding]; other site 675635005256 dimerization interface [polypeptide binding]; other site 675635005257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635005258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635005259 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 675635005260 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 675635005261 acyl-activating enzyme (AAE) consensus motif; other site 675635005262 putative AMP binding site [chemical binding]; other site 675635005263 putative active site [active] 675635005264 putative CoA binding site [chemical binding]; other site 675635005265 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635005266 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635005267 substrate binding site [chemical binding]; other site 675635005268 oxyanion hole (OAH) forming residues; other site 675635005269 trimer interface [polypeptide binding]; other site 675635005270 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635005271 substrate binding site [chemical binding]; other site 675635005272 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635005273 trimer interface [polypeptide binding]; other site 675635005274 oxyanion hole (OAH) forming residues; other site 675635005275 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635005276 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 675635005277 ligand binding site [chemical binding]; other site 675635005278 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635005279 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 675635005280 TM-ABC transporter signature motif; other site 675635005281 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635005282 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 675635005283 Walker A/P-loop; other site 675635005284 ATP binding site [chemical binding]; other site 675635005285 Q-loop/lid; other site 675635005286 ABC transporter signature motif; other site 675635005287 Walker B; other site 675635005288 D-loop; other site 675635005289 H-loop/switch region; other site 675635005290 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635005291 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 675635005292 Walker A/P-loop; other site 675635005293 ATP binding site [chemical binding]; other site 675635005294 Q-loop/lid; other site 675635005295 ABC transporter signature motif; other site 675635005296 Walker B; other site 675635005297 D-loop; other site 675635005298 H-loop/switch region; other site 675635005299 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635005300 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635005301 TM-ABC transporter signature motif; other site 675635005302 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635005303 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635005304 substrate binding site [chemical binding]; other site 675635005305 oxyanion hole (OAH) forming residues; other site 675635005306 trimer interface [polypeptide binding]; other site 675635005307 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 675635005308 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635005309 NAD(P) binding site [chemical binding]; other site 675635005310 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635005311 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635005312 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635005313 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635005314 active site 2 [active] 675635005315 active site 1 [active] 675635005316 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 675635005317 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635005318 tetramer interface [polypeptide binding]; other site 675635005319 TPP-binding site [chemical binding]; other site 675635005320 heterodimer interface [polypeptide binding]; other site 675635005321 phosphorylation loop region [posttranslational modification] 675635005322 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635005323 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 675635005324 alpha subunit interface [polypeptide binding]; other site 675635005325 TPP binding site [chemical binding]; other site 675635005326 heterodimer interface [polypeptide binding]; other site 675635005327 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635005328 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 675635005329 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635005330 E3 interaction surface; other site 675635005331 lipoyl attachment site [posttranslational modification]; other site 675635005332 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 675635005333 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 675635005334 acyl-activating enzyme (AAE) consensus motif; other site 675635005335 putative AMP binding site [chemical binding]; other site 675635005336 putative active site [active] 675635005337 putative CoA binding site [chemical binding]; other site 675635005338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635005339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635005340 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635005341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635005342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 675635005343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635005344 Coenzyme A binding pocket [chemical binding]; other site 675635005345 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635005346 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 675635005347 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 675635005348 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 675635005349 Hexamer interface [polypeptide binding]; other site 675635005350 Hexagonal pore residue; other site 675635005351 GAF domain; Region: GAF_2; pfam13185 675635005352 GAF domain; Region: GAF_3; pfam13492 675635005353 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635005354 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 675635005355 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635005356 catalytic Zn binding site [ion binding]; other site 675635005357 NAD(P) binding site [chemical binding]; other site 675635005358 structural Zn binding site [ion binding]; other site 675635005359 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 675635005360 NAD(P) binding site [chemical binding]; other site 675635005361 LDH/MDH dimer interface [polypeptide binding]; other site 675635005362 substrate binding site [chemical binding]; other site 675635005363 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 675635005364 putative hexamer interface [polypeptide binding]; other site 675635005365 putative hexagonal pore; other site 675635005366 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 675635005367 putative hexamer interface [polypeptide binding]; other site 675635005368 putative hexagonal pore; other site 675635005369 ethanolamine utilization protein EutJ family protein; Region: EutJ; TIGR02529 675635005370 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 675635005371 putative catalytic cysteine [active] 675635005372 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 675635005373 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 675635005374 Hexamer interface [polypeptide binding]; other site 675635005375 Hexagonal pore residue; other site 675635005376 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cl01889 675635005377 Hexamer/Pentamer interface [polypeptide binding]; other site 675635005378 central pore; other site 675635005379 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 675635005380 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 675635005381 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 675635005382 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 675635005383 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 675635005384 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 675635005385 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 675635005386 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 675635005387 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 675635005388 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 675635005389 homodimer interface [polypeptide binding]; other site 675635005390 NADP binding site [chemical binding]; other site 675635005391 substrate binding site [chemical binding]; other site 675635005392 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 675635005393 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 675635005394 substrate binding site [chemical binding]; other site 675635005395 ATP binding site [chemical binding]; other site 675635005396 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 675635005397 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 675635005398 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 675635005399 putative active site [active] 675635005400 putative substrate binding site [chemical binding]; other site 675635005401 putative cosubstrate binding site; other site 675635005402 catalytic site [active] 675635005403 S-adenosylmethionine synthetase; Validated; Region: PRK05250 675635005404 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 675635005405 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 675635005406 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 675635005407 methionine synthase; Provisional; Region: PRK01207 675635005408 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635005409 substrate binding site [chemical binding]; other site 675635005410 THF binding site; other site 675635005411 zinc-binding site [ion binding]; other site 675635005412 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 675635005413 FAD binding site [chemical binding]; other site 675635005414 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 675635005415 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635005416 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 675635005417 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 675635005418 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 675635005419 FAD binding site [chemical binding]; other site 675635005420 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 675635005421 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635005422 active site 675635005423 catalytic triad [active] 675635005424 oxyanion hole [active] 675635005425 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 675635005426 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 675635005427 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 675635005428 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 675635005429 active site 675635005430 Zn binding site [ion binding]; other site 675635005431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635005432 putative transporter; Provisional; Region: PRK10504 675635005433 putative substrate translocation pore; other site 675635005434 Cupin domain; Region: Cupin_2; pfam07883 675635005435 short chain dehydrogenase; Provisional; Region: PRK08219 675635005436 classical (c) SDRs; Region: SDR_c; cd05233 675635005437 NAD(P) binding site [chemical binding]; other site 675635005438 active site 675635005439 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 675635005440 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 675635005441 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 675635005442 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635005443 active site 675635005444 metal binding site [ion binding]; metal-binding site 675635005445 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 675635005446 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 675635005447 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 675635005448 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 675635005449 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 675635005450 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 675635005451 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 675635005452 HflX GTPase family; Region: HflX; cd01878 675635005453 G1 box; other site 675635005454 GTP/Mg2+ binding site [chemical binding]; other site 675635005455 Switch I region; other site 675635005456 G2 box; other site 675635005457 G3 box; other site 675635005458 Switch II region; other site 675635005459 G4 box; other site 675635005460 G5 box; other site 675635005461 LexA repressor; Validated; Region: PRK00215 675635005462 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 675635005463 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 675635005464 Catalytic site [active] 675635005465 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 675635005466 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 675635005467 ATP cone domain; Region: ATP-cone; pfam03477 675635005468 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 675635005469 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 675635005470 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 675635005471 active site 675635005472 dimer interface [polypeptide binding]; other site 675635005473 effector binding site; other site 675635005474 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 675635005475 TSCPD domain; Region: TSCPD; pfam12637 675635005476 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635005477 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635005478 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635005479 nudix motif; other site 675635005480 DNA binding domain, excisionase family; Region: excise; TIGR01764 675635005481 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 675635005482 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 675635005483 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635005484 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 675635005485 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 675635005486 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 675635005487 dimer interface [polypeptide binding]; other site 675635005488 active site 675635005489 acyl carrier protein; Provisional; Region: acpP; PRK00982 675635005490 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 675635005491 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 675635005492 dimer interface [polypeptide binding]; other site 675635005493 active site 675635005494 CoA binding pocket [chemical binding]; other site 675635005495 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 675635005496 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635005497 Pirin-related protein [General function prediction only]; Region: COG1741 675635005498 Pirin; Region: Pirin; pfam02678 675635005499 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 675635005500 DNA-binding site [nucleotide binding]; DNA binding site 675635005501 RNA-binding motif; other site 675635005502 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 675635005503 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 675635005504 dimer interface [polypeptide binding]; other site 675635005505 TPP-binding site [chemical binding]; other site 675635005506 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 675635005507 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 675635005508 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 675635005509 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 675635005510 dimer interface [polypeptide binding]; other site 675635005511 catalytic triad [active] 675635005512 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 675635005513 active site 675635005514 substrate binding pocket [chemical binding]; other site 675635005515 homodimer interaction site [polypeptide binding]; other site 675635005516 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 675635005517 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 675635005518 active site 675635005519 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635005520 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635005521 active site 675635005522 catalytic tetrad [active] 675635005523 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 675635005524 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 675635005525 NIPSNAP; Region: NIPSNAP; pfam07978 675635005526 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635005527 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 675635005528 NAD(P) binding site [chemical binding]; other site 675635005529 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 675635005530 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 675635005531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635005532 Walker A motif; other site 675635005533 ATP binding site [chemical binding]; other site 675635005534 Walker B motif; other site 675635005535 arginine finger; other site 675635005536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635005537 Integrase core domain; Region: rve; pfam00665 675635005538 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 675635005539 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 675635005540 active site 675635005541 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 675635005542 active site 675635005543 substrate binding pocket [chemical binding]; other site 675635005544 homodimer interaction site [polypeptide binding]; other site 675635005545 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 675635005546 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 675635005547 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635005548 NAD binding site [chemical binding]; other site 675635005549 catalytic residues [active] 675635005550 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635005551 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 675635005552 NAD(P) binding site [chemical binding]; other site 675635005553 catalytic residues [active] 675635005554 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 675635005555 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635005556 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635005557 DNA binding site [nucleotide binding] 675635005558 domain linker motif; other site 675635005559 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 675635005560 dimerization interface [polypeptide binding]; other site 675635005561 ligand binding site [chemical binding]; other site 675635005562 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 675635005563 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 675635005564 ATP binding site [chemical binding]; other site 675635005565 substrate binding site [chemical binding]; other site 675635005566 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 675635005567 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 675635005568 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635005569 active site 675635005570 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635005571 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635005572 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635005573 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635005574 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635005575 active site 675635005576 Putative serine esterase (DUF676); Region: DUF676; pfam05057 675635005577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635005578 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635005579 catalytic site [active] 675635005580 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 675635005581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 675635005582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635005583 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 675635005584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635005585 active site 675635005586 motif I; other site 675635005587 motif II; other site 675635005588 NIPSNAP; Region: NIPSNAP; pfam07978 675635005589 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635005590 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635005591 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 675635005592 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635005593 phosphate binding site [ion binding]; other site 675635005594 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 675635005595 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 675635005596 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 675635005597 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 675635005598 active site 675635005599 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 675635005600 active site 675635005601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635005602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635005603 dimer interface [polypeptide binding]; other site 675635005604 conserved gate region; other site 675635005605 putative PBP binding loops; other site 675635005606 ABC-ATPase subunit interface; other site 675635005607 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635005608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635005609 dimer interface [polypeptide binding]; other site 675635005610 conserved gate region; other site 675635005611 ABC-ATPase subunit interface; other site 675635005612 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635005613 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 675635005614 Walker A/P-loop; other site 675635005615 ATP binding site [chemical binding]; other site 675635005616 Q-loop/lid; other site 675635005617 ABC transporter signature motif; other site 675635005618 Walker B; other site 675635005619 D-loop; other site 675635005620 H-loop/switch region; other site 675635005621 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635005622 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635005623 Walker A/P-loop; other site 675635005624 ATP binding site [chemical binding]; other site 675635005625 Q-loop/lid; other site 675635005626 ABC transporter signature motif; other site 675635005627 Walker B; other site 675635005628 D-loop; other site 675635005629 H-loop/switch region; other site 675635005630 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635005631 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635005632 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635005633 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635005634 active site 675635005635 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635005636 non-prolyl cis peptide bond; other site 675635005637 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635005638 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635005639 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 675635005640 NADH(P)-binding; Region: NAD_binding_10; pfam13460 675635005641 NAD binding site [chemical binding]; other site 675635005642 substrate binding site [chemical binding]; other site 675635005643 putative active site [active] 675635005644 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635005645 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635005646 dimer interface [polypeptide binding]; other site 675635005647 active site 675635005648 non-prolyl cis peptide bond; other site 675635005649 insertion regions; other site 675635005650 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635005651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635005652 active site 675635005653 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635005654 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635005655 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 675635005656 molybdopterin cofactor binding site; other site 675635005657 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 675635005658 molybdopterin cofactor binding site; other site 675635005659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635005660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635005661 dimerization interface [polypeptide binding]; other site 675635005662 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635005663 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 675635005664 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 675635005665 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635005666 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 675635005667 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635005668 active site residue [active] 675635005669 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635005670 active site residue [active] 675635005671 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635005672 active site 675635005673 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 675635005674 dimer interface [polypeptide binding]; other site 675635005675 non-prolyl cis peptide bond; other site 675635005676 insertion regions; other site 675635005677 FAD binding domain; Region: FAD_binding_4; pfam01565 675635005678 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 675635005679 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 675635005680 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 675635005681 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 675635005682 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 675635005683 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635005684 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635005685 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635005686 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 675635005687 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 675635005688 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 675635005689 nucleotide binding site [chemical binding]; other site 675635005690 GrpE; Region: GrpE; pfam01025 675635005691 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 675635005692 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 675635005693 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 675635005694 HSP70 interaction site [polypeptide binding]; other site 675635005695 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 675635005696 substrate binding site [polypeptide binding]; other site 675635005697 dimer interface [polypeptide binding]; other site 675635005698 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 675635005699 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 675635005700 Clp amino terminal domain; Region: Clp_N; pfam02861 675635005701 Clp amino terminal domain; Region: Clp_N; pfam02861 675635005702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635005703 Walker A motif; other site 675635005704 ATP binding site [chemical binding]; other site 675635005705 Walker B motif; other site 675635005706 arginine finger; other site 675635005707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635005708 Walker A motif; other site 675635005709 ATP binding site [chemical binding]; other site 675635005710 Walker B motif; other site 675635005711 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 675635005712 thioredoxin 2; Provisional; Region: PRK10996 675635005713 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635005714 catalytic residues [active] 675635005715 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 675635005716 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635005717 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635005718 ligand binding site [chemical binding]; other site 675635005719 flexible hinge region; other site 675635005720 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 675635005721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635005722 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635005723 DNA binding residues [nucleotide binding] 675635005724 dimerization interface [polypeptide binding]; other site 675635005725 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635005726 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 675635005727 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635005728 Soluble P-type ATPase [General function prediction only]; Region: COG4087 675635005729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635005730 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635005731 putative substrate translocation pore; other site 675635005732 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 675635005733 amphipathic channel; other site 675635005734 Asn-Pro-Ala signature motifs; other site 675635005735 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635005736 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 675635005737 active site 675635005738 dimer interface [polypeptide binding]; other site 675635005739 metal binding site [ion binding]; metal-binding site 675635005740 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 675635005741 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 675635005742 active site 675635005743 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635005744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635005745 DNA binding residues [nucleotide binding] 675635005746 dimerization interface [polypeptide binding]; other site 675635005747 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 675635005748 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635005749 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 675635005750 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635005751 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635005752 DNA binding residues [nucleotide binding] 675635005753 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 675635005754 YCII-related domain; Region: YCII; cl00999 675635005755 Predicted membrane protein [Function unknown]; Region: COG2259 675635005756 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 675635005757 classical (c) SDRs; Region: SDR_c; cd05233 675635005758 NAD(P) binding site [chemical binding]; other site 675635005759 active site 675635005760 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635005761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635005762 thiolase; Provisional; Region: PRK06158 675635005763 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635005764 active site 675635005765 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635005766 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635005767 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 675635005768 CoA binding domain; Region: CoA_binding_2; pfam13380 675635005769 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 675635005770 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 675635005771 Putative cyclase; Region: Cyclase; pfam04199 675635005772 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635005773 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635005774 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 675635005775 classical (c) SDRs; Region: SDR_c; cd05233 675635005776 NAD(P) binding site [chemical binding]; other site 675635005777 active site 675635005778 SnoaL-like domain; Region: SnoaL_3; pfam13474 675635005779 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635005780 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635005781 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635005782 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635005783 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 675635005784 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 675635005785 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 675635005786 active site 675635005787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 675635005788 Walker A motif; other site 675635005789 ATP binding site [chemical binding]; other site 675635005790 Walker B motif; other site 675635005791 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 675635005792 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635005793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635005794 DNA-binding site [nucleotide binding]; DNA binding site 675635005795 FCD domain; Region: FCD; pfam07729 675635005796 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 675635005797 classical (c) SDRs; Region: SDR_c; cd05233 675635005798 NAD(P) binding site [chemical binding]; other site 675635005799 active site 675635005800 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635005801 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635005802 putative NAD(P) binding site [chemical binding]; other site 675635005803 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635005804 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 675635005805 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635005806 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 675635005807 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635005808 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635005809 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635005810 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635005811 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 675635005812 classical (c) SDRs; Region: SDR_c; cd05233 675635005813 NAD(P) binding site [chemical binding]; other site 675635005814 active site 675635005815 Epoxide hydrolase N terminus; Region: EHN; pfam06441 675635005816 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635005817 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635005818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635005819 Walker A motif; other site 675635005820 ATP binding site [chemical binding]; other site 675635005821 Walker B motif; other site 675635005822 arginine finger; other site 675635005823 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 675635005824 metal ion-dependent adhesion site (MIDAS); other site 675635005825 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 675635005826 classical (c) SDRs; Region: SDR_c; cd05233 675635005827 NAD(P) binding site [chemical binding]; other site 675635005828 active site 675635005829 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635005830 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635005831 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635005832 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 675635005833 Walker A/P-loop; other site 675635005834 ATP binding site [chemical binding]; other site 675635005835 Q-loop/lid; other site 675635005836 ABC transporter signature motif; other site 675635005837 Walker B; other site 675635005838 D-loop; other site 675635005839 H-loop/switch region; other site 675635005840 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 675635005841 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635005842 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635005843 TM-ABC transporter signature motif; other site 675635005844 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635005845 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635005846 TM-ABC transporter signature motif; other site 675635005847 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635005848 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 675635005849 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 675635005850 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635005851 catalytic Zn binding site [ion binding]; other site 675635005852 structural Zn binding site [ion binding]; other site 675635005853 tetramer interface [polypeptide binding]; other site 675635005854 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 675635005855 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635005856 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635005857 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635005858 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635005859 MarR family; Region: MarR; pfam01047 675635005860 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 675635005861 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 675635005862 Cl- selectivity filter; other site 675635005863 Cl- binding residues [ion binding]; other site 675635005864 pore gating glutamate residue; other site 675635005865 dimer interface [polypeptide binding]; other site 675635005866 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635005867 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635005868 Transcriptional regulator; Region: Rrf2; pfam02082 675635005869 WYL domain; Region: WYL; pfam13280 675635005870 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635005871 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635005872 active site 675635005873 metal binding site [ion binding]; metal-binding site 675635005874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 675635005875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 675635005876 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635005877 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 675635005878 active site 675635005879 dimer interface [polypeptide binding]; other site 675635005880 metal binding site [ion binding]; metal-binding site 675635005881 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635005882 active site 1 [active] 675635005883 dimer interface [polypeptide binding]; other site 675635005884 active site 2 [active] 675635005885 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635005886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635005887 NAD(P) binding site [chemical binding]; other site 675635005888 active site 675635005889 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 675635005890 active site 675635005891 Bacterial transcriptional activator domain; Region: BTAD; smart01043 675635005892 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 675635005893 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635005894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635005895 DNA binding residues [nucleotide binding] 675635005896 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 675635005897 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635005898 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 675635005899 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 675635005900 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 675635005901 active site 675635005902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635005903 Walker A/P-loop; other site 675635005904 ATP binding site [chemical binding]; other site 675635005905 ABC transporter; Region: ABC_tran; pfam00005 675635005906 Q-loop/lid; other site 675635005907 ABC transporter signature motif; other site 675635005908 Walker B; other site 675635005909 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 675635005910 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 675635005911 Universal stress protein family; Region: Usp; pfam00582 675635005912 FOG: CBS domain [General function prediction only]; Region: COG0517 675635005913 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635005914 Short C-terminal domain; Region: SHOCT; pfam09851 675635005915 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 675635005916 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635005917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635005918 active site 675635005919 phosphorylation site [posttranslational modification] 675635005920 intermolecular recognition site; other site 675635005921 dimerization interface [polypeptide binding]; other site 675635005922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635005923 DNA binding residues [nucleotide binding] 675635005924 dimerization interface [polypeptide binding]; other site 675635005925 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 675635005926 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 675635005927 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 675635005928 Domain of unknown function (DUF385); Region: DUF385; cl04387 675635005929 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635005930 Ligand Binding Site [chemical binding]; other site 675635005931 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635005932 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 675635005933 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 675635005934 trimer interface [polypeptide binding]; other site 675635005935 putative metal binding site [ion binding]; other site 675635005936 Predicted membrane protein [Function unknown]; Region: COG2860 675635005937 UPF0126 domain; Region: UPF0126; pfam03458 675635005938 UPF0126 domain; Region: UPF0126; pfam03458 675635005939 glutamate dehydrogenase; Provisional; Region: PRK09414 675635005940 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 675635005941 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 675635005942 NAD(P) binding pocket [chemical binding]; other site 675635005943 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635005944 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 675635005945 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 675635005946 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 675635005947 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635005948 MarR family; Region: MarR_2; cl17246 675635005949 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 675635005950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635005951 active site 675635005952 phosphorylation site [posttranslational modification] 675635005953 intermolecular recognition site; other site 675635005954 dimerization interface [polypeptide binding]; other site 675635005955 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 675635005956 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635005957 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635005958 anti sigma factor interaction site; other site 675635005959 regulatory phosphorylation site [posttranslational modification]; other site 675635005960 CheB methylesterase; Region: CheB_methylest; pfam01339 675635005961 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 675635005962 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 675635005963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635005964 S-adenosylmethionine binding site [chemical binding]; other site 675635005965 PAS domain; Region: PAS_9; pfam13426 675635005966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635005967 putative active site [active] 675635005968 heme pocket [chemical binding]; other site 675635005969 PAS domain S-box; Region: sensory_box; TIGR00229 675635005970 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635005971 anti sigma factor interaction site; other site 675635005972 regulatory phosphorylation site [posttranslational modification]; other site 675635005973 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635005974 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635005975 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635005976 DNA binding residues [nucleotide binding] 675635005977 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635005978 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635005979 ligand binding site [chemical binding]; other site 675635005980 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635005981 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635005982 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 675635005983 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635005984 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635005985 GAF domain; Region: GAF_3; pfam13492 675635005986 GAF domain; Region: GAF_2; pfam13185 675635005987 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635005988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635005989 dimer interface [polypeptide binding]; other site 675635005990 phosphorylation site [posttranslational modification] 675635005991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635005992 ATP binding site [chemical binding]; other site 675635005993 Mg2+ binding site [ion binding]; other site 675635005994 G-X-G motif; other site 675635005995 Response regulator receiver domain; Region: Response_reg; pfam00072 675635005996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635005997 active site 675635005998 phosphorylation site [posttranslational modification] 675635005999 intermolecular recognition site; other site 675635006000 dimerization interface [polypeptide binding]; other site 675635006001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635006002 PAS domain; Region: PAS_9; pfam13426 675635006003 putative active site [active] 675635006004 heme pocket [chemical binding]; other site 675635006005 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635006006 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 675635006007 GAF domain; Region: GAF; cl17456 675635006008 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 675635006009 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635006010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635006011 ATP binding site [chemical binding]; other site 675635006012 Mg2+ binding site [ion binding]; other site 675635006013 G-X-G motif; other site 675635006014 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635006015 anti sigma factor interaction site; other site 675635006016 regulatory phosphorylation site [posttranslational modification]; other site 675635006017 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 675635006018 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 675635006019 Walker A/P-loop; other site 675635006020 ATP binding site [chemical binding]; other site 675635006021 Q-loop/lid; other site 675635006022 ABC transporter signature motif; other site 675635006023 Walker B; other site 675635006024 D-loop; other site 675635006025 H-loop/switch region; other site 675635006026 Cobalt transport protein; Region: CbiQ; cl00463 675635006027 cobalt transport protein CbiM; Provisional; Region: PRK11909 675635006028 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 675635006029 High-affinity nickel-transport protein; Region: NicO; cl00964 675635006030 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 675635006031 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 675635006032 dimer interface [polypeptide binding]; other site 675635006033 decamer (pentamer of dimers) interface [polypeptide binding]; other site 675635006034 catalytic triad [active] 675635006035 EamA-like transporter family; Region: EamA; cl17759 675635006036 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 675635006037 ATP binding site [chemical binding]; other site 675635006038 substrate binding site [chemical binding]; other site 675635006039 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635006040 catalytic core [active] 675635006041 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635006042 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 675635006043 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 675635006044 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 675635006045 putative ADP-binding pocket [chemical binding]; other site 675635006046 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635006047 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 675635006048 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 675635006049 Predicted membrane protein [Function unknown]; Region: COG5373 675635006050 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 675635006051 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 675635006052 oligomer interface [polypeptide binding]; other site 675635006053 metal binding site [ion binding]; metal-binding site 675635006054 metal binding site [ion binding]; metal-binding site 675635006055 putative Cl binding site [ion binding]; other site 675635006056 aspartate ring; other site 675635006057 basic sphincter; other site 675635006058 hydrophobic gate; other site 675635006059 periplasmic entrance; other site 675635006060 Hemerythrin-like domain; Region: Hr-like; cd12108 675635006061 oxidoreductase; Provisional; Region: PRK06128 675635006062 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 675635006063 NAD binding site [chemical binding]; other site 675635006064 metal binding site [ion binding]; metal-binding site 675635006065 active site 675635006066 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635006067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635006068 ATP binding site [chemical binding]; other site 675635006069 Mg2+ binding site [ion binding]; other site 675635006070 G-X-G motif; other site 675635006071 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 675635006072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635006073 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635006074 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 675635006075 active site 675635006076 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 675635006077 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 675635006078 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 675635006079 Putative ubiquinol binding site [chemical binding]; other site 675635006080 Low-spin heme (heme b) binding site [chemical binding]; other site 675635006081 D-pathway; other site 675635006082 Putative water exit pathway; other site 675635006083 Binuclear center (heme o3/CuB) [ion binding]; other site 675635006084 K-pathway; other site 675635006085 Putative proton exit pathway; other site 675635006086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635006088 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635006089 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635006090 catalytic loop [active] 675635006091 iron binding site [ion binding]; other site 675635006092 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635006093 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635006094 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635006095 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635006096 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635006097 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635006098 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635006099 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 675635006100 putative NAD(P) binding site [chemical binding]; other site 675635006101 active site 675635006102 putative substrate binding site [chemical binding]; other site 675635006103 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 675635006104 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635006105 NAD binding site [chemical binding]; other site 675635006106 catalytic Zn binding site [ion binding]; other site 675635006107 structural Zn binding site [ion binding]; other site 675635006108 FOG: CBS domain [General function prediction only]; Region: COG0517 675635006109 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 675635006110 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 675635006111 dimanganese center [ion binding]; other site 675635006112 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 675635006113 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 675635006114 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 675635006115 putative methyltransferase; Provisional; Region: PRK14967 675635006116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635006117 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635006118 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 675635006119 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635006120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635006121 dimer interface [polypeptide binding]; other site 675635006122 conserved gate region; other site 675635006123 putative PBP binding loops; other site 675635006124 ABC-ATPase subunit interface; other site 675635006125 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635006126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635006127 ABC-ATPase subunit interface; other site 675635006128 putative PBP binding loops; other site 675635006129 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 675635006130 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635006131 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 675635006132 ANTAR domain; Region: ANTAR; pfam03861 675635006133 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 675635006134 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635006135 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635006136 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 675635006137 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635006138 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635006139 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635006140 DNA binding residues [nucleotide binding] 675635006141 GAF domain; Region: GAF; pfam01590 675635006142 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 675635006143 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635006144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635006145 Mg2+ binding site [ion binding]; other site 675635006146 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635006147 anti sigma factor interaction site; other site 675635006148 regulatory phosphorylation site [posttranslational modification]; other site 675635006149 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 675635006150 putative hydrophobic ligand binding site [chemical binding]; other site 675635006151 Gas vesicle protein; Region: Gas_vesicle; cl02954 675635006152 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 675635006153 Gas vesicle protein G; Region: GvpG; pfam05120 675635006154 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 675635006155 Gas vesicle protein; Region: Gas_vesicle; pfam00741 675635006156 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 675635006157 Gas vesicle protein K; Region: GvpK; pfam05121 675635006158 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 675635006159 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635006160 active site 675635006161 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 675635006162 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 675635006163 dimerization interface [polypeptide binding]; other site 675635006164 DPS ferroxidase diiron center [ion binding]; other site 675635006165 ion pore; other site 675635006166 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635006167 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635006168 DinB superfamily; Region: DinB_2; pfam12867 675635006169 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635006170 F420H2 dehydrogenase subunit FpoO; Region: FpoO; pfam10621 675635006171 MULE transposase domain; Region: MULE; pfam10551 675635006172 Low molecular weight phosphatase family; Region: LMWPc; cl00105 675635006173 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 675635006174 active site 675635006175 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 675635006176 arsenical-resistance protein; Region: acr3; TIGR00832 675635006177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635006178 dimerization interface [polypeptide binding]; other site 675635006179 putative DNA binding site [nucleotide binding]; other site 675635006180 putative Zn2+ binding site [ion binding]; other site 675635006181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635006182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006183 putative substrate translocation pore; other site 675635006184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635006185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635006186 dimerization interface [polypeptide binding]; other site 675635006187 putative DNA binding site [nucleotide binding]; other site 675635006188 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635006189 putative Zn2+ binding site [ion binding]; other site 675635006190 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 675635006191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635006192 Coenzyme A binding pocket [chemical binding]; other site 675635006193 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 675635006194 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 675635006195 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 675635006196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635006197 motif II; other site 675635006198 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 675635006199 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 675635006200 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 675635006201 4Fe-4S binding domain; Region: Fer4; cl02805 675635006202 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 675635006203 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635006204 molybdopterin cofactor binding site; other site 675635006205 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635006206 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635006207 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 675635006208 molybdopterin cofactor binding site; other site 675635006209 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 675635006210 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 675635006211 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 675635006212 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 675635006213 FAD binding site [chemical binding]; other site 675635006214 Methyltransferase domain; Region: Methyltransf_11; pfam08241 675635006215 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635006216 hydrophobic ligand binding site; other site 675635006217 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 675635006218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 675635006219 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 675635006220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635006221 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635006222 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635006223 DNA binding residues [nucleotide binding] 675635006224 thiamine pyrophosphate protein; Provisional; Region: PRK08273 675635006225 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 675635006226 PYR/PP interface [polypeptide binding]; other site 675635006227 dimer interface [polypeptide binding]; other site 675635006228 tetramer interface [polypeptide binding]; other site 675635006229 TPP binding site [chemical binding]; other site 675635006230 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 675635006231 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 675635006232 TPP-binding site [chemical binding]; other site 675635006233 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 675635006234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635006235 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635006236 classical (c) SDRs; Region: SDR_c; cd05233 675635006237 NAD(P) binding site [chemical binding]; other site 675635006238 active site 675635006239 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635006240 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635006241 active site 675635006242 catalytic tetrad [active] 675635006243 GAF domain; Region: GAF; cl17456 675635006244 GAF domain; Region: GAF_2; pfam13185 675635006245 GAF domain; Region: GAF; cl17456 675635006246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635006247 Histidine kinase; Region: HisKA_3; pfam07730 675635006248 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635006249 dimer interface [polypeptide binding]; other site 675635006250 FOG: CBS domain [General function prediction only]; Region: COG0517 675635006251 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 675635006252 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 675635006253 putative metal binding site [ion binding]; other site 675635006254 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 675635006255 Transglycosylase; Region: Transgly; pfam00912 675635006256 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 675635006257 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 675635006258 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635006259 TAP-like protein; Region: Abhydrolase_4; pfam08386 675635006260 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635006261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635006262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635006263 Walker A/P-loop; other site 675635006264 ATP binding site [chemical binding]; other site 675635006265 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 675635006266 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635006267 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 675635006268 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 675635006269 enoyl-CoA hydratase; Provisional; Region: PRK08252 675635006270 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006271 substrate binding site [chemical binding]; other site 675635006272 oxyanion hole (OAH) forming residues; other site 675635006273 trimer interface [polypeptide binding]; other site 675635006274 Na binding site [ion binding]; other site 675635006275 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 675635006276 Isochorismatase family; Region: Isochorismatase; pfam00857 675635006277 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 675635006278 catalytic triad [active] 675635006279 conserved cis-peptide bond; other site 675635006280 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635006281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635006282 DNA-binding site [nucleotide binding]; DNA binding site 675635006283 UTRA domain; Region: UTRA; cl17743 675635006284 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635006285 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635006286 Amidase; Region: Amidase; cl11426 675635006287 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635006288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635006289 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635006290 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635006291 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 675635006292 classical (c) SDRs; Region: SDR_c; cd05233 675635006293 NAD(P) binding site [chemical binding]; other site 675635006294 active site 675635006295 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635006296 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 675635006297 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635006298 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635006299 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635006300 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635006301 GAF domain; Region: GAF; pfam01590 675635006302 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635006303 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635006304 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635006305 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635006306 acyl-activating enzyme (AAE) consensus motif; other site 675635006307 acyl-activating enzyme (AAE) consensus motif; other site 675635006308 AMP binding site [chemical binding]; other site 675635006309 active site 675635006310 CoA binding site [chemical binding]; other site 675635006311 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 675635006312 The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925 675635006313 putative dimer interface [polypeptide binding]; other site 675635006314 putative tetramer interface [polypeptide binding]; other site 675635006315 putative active site [active] 675635006316 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635006317 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 675635006318 active site 675635006319 metal binding site [ion binding]; metal-binding site 675635006320 Predicted amidohydrolase [General function prediction only]; Region: COG0388 675635006321 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 675635006322 putative active site [active] 675635006323 catalytic triad [active] 675635006324 putative dimer interface [polypeptide binding]; other site 675635006325 adenosine deaminase; Provisional; Region: PRK09358 675635006326 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 675635006327 active site 675635006328 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635006329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635006330 DNA-binding site [nucleotide binding]; DNA binding site 675635006331 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635006332 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635006333 active site 675635006334 catalytic tetrad [active] 675635006335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635006337 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635006338 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635006339 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635006340 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635006341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635006343 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 675635006344 iron-sulfur cluster [ion binding]; other site 675635006345 [2Fe-2S] cluster binding site [ion binding]; other site 675635006346 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635006347 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 675635006348 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 675635006349 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 675635006350 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 675635006351 active site 675635006352 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635006353 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635006354 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635006355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635006356 active site 675635006357 metal binding site [ion binding]; metal-binding site 675635006358 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635006359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635006360 Walker A/P-loop; other site 675635006361 ATP binding site [chemical binding]; other site 675635006362 Q-loop/lid; other site 675635006363 ABC transporter signature motif; other site 675635006364 Walker B; other site 675635006365 D-loop; other site 675635006366 H-loop/switch region; other site 675635006367 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635006368 TM-ABC transporter signature motif; other site 675635006369 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635006370 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 675635006371 ligand binding site [chemical binding]; other site 675635006372 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 675635006373 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635006374 TM-ABC transporter signature motif; other site 675635006375 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635006376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635006377 Walker A/P-loop; other site 675635006378 ATP binding site [chemical binding]; other site 675635006379 Q-loop/lid; other site 675635006380 ABC transporter signature motif; other site 675635006381 Walker B; other site 675635006382 D-loop; other site 675635006383 H-loop/switch region; other site 675635006384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635006386 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 675635006387 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 675635006388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635006389 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 675635006390 dimerization interface [polypeptide binding]; other site 675635006391 substrate binding pocket [chemical binding]; other site 675635006392 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 675635006393 RNA/DNA hybrid binding site [nucleotide binding]; other site 675635006394 active site 675635006395 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635006396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635006397 thiolase; Provisional; Region: PRK06158 675635006398 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635006399 active site 675635006400 Nucleolar RNA-binding protein, Nop10p family; Region: Nop10p; cl00977 675635006401 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635006402 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 675635006403 Putative cyclase; Region: Cyclase; pfam04199 675635006404 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635006405 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635006406 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635006407 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635006408 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 675635006409 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635006410 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635006411 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 675635006412 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635006413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635006414 DNA-binding site [nucleotide binding]; DNA binding site 675635006415 FCD domain; Region: FCD; pfam07729 675635006416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006417 enoyl-CoA hydratase; Provisional; Region: PRK09245 675635006418 substrate binding site [chemical binding]; other site 675635006419 oxyanion hole (OAH) forming residues; other site 675635006420 trimer interface [polypeptide binding]; other site 675635006421 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 675635006422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635006423 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635006424 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 675635006425 mycothione reductase; Reviewed; Region: PRK07846 675635006426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635006427 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635006428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635006429 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635006430 dimerization interface [polypeptide binding]; other site 675635006431 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 675635006432 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 675635006433 Putative cyclase; Region: Cyclase; pfam04199 675635006434 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635006435 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 675635006436 NAD binding site [chemical binding]; other site 675635006437 catalytic residues [active] 675635006438 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635006439 active site 1 [active] 675635006440 dimer interface [polypeptide binding]; other site 675635006441 hexamer interface [polypeptide binding]; other site 675635006442 active site 2 [active] 675635006443 Tautomerase enzyme; Region: Tautomerase; pfam01361 675635006444 active site 1 [active] 675635006445 dimer interface [polypeptide binding]; other site 675635006446 hexamer interface [polypeptide binding]; other site 675635006447 active site 2 [active] 675635006448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006449 NAD(P) binding site [chemical binding]; other site 675635006450 active site 675635006451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635006452 hypothetical protein; Provisional; Region: PRK08296 675635006453 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 675635006454 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 675635006455 OsmC-like protein; Region: OsmC; pfam02566 675635006456 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 675635006457 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635006458 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635006459 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 675635006460 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635006461 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635006462 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635006463 iron-sulfur cluster [ion binding]; other site 675635006464 [2Fe-2S] cluster binding site [ion binding]; other site 675635006465 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635006466 hydrophobic ligand binding site; other site 675635006467 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635006468 iron-sulfur cluster [ion binding]; other site 675635006469 [2Fe-2S] cluster binding site [ion binding]; other site 675635006470 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635006471 active site 1 [active] 675635006472 dimer interface [polypeptide binding]; other site 675635006473 hexamer interface [polypeptide binding]; other site 675635006474 active site 2 [active] 675635006475 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635006476 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635006477 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635006478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635006479 putative DNA binding site [nucleotide binding]; other site 675635006480 putative Zn2+ binding site [ion binding]; other site 675635006481 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635006482 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 675635006483 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635006484 active site 675635006485 metal binding site [ion binding]; metal-binding site 675635006486 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635006487 active site 675635006488 metal binding site [ion binding]; metal-binding site 675635006489 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 675635006490 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635006491 active site 675635006492 metal binding site [ion binding]; metal-binding site 675635006493 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635006494 active site 675635006495 metal binding site [ion binding]; metal-binding site 675635006496 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 675635006497 catalytic core [active] 675635006498 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635006499 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635006500 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635006501 Domain of unknown function (DUF385); Region: DUF385; pfam04075 675635006502 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635006503 substrate binding site [chemical binding]; other site 675635006504 THF binding site; other site 675635006505 zinc-binding site [ion binding]; other site 675635006506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635006508 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635006509 Cytochrome P450; Region: p450; cl12078 675635006510 lipid-transfer protein; Provisional; Region: PRK08256 675635006511 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635006512 active site 675635006513 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635006514 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635006515 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635006516 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 675635006517 classical (c) SDRs; Region: SDR_c; cd05233 675635006518 NAD(P) binding site [chemical binding]; other site 675635006519 active site 675635006520 acyl-CoA synthetase; Validated; Region: PRK06188 675635006521 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635006522 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635006523 putative AMP binding site [chemical binding]; other site 675635006524 putative active site [active] 675635006525 acyl-activating enzyme (AAE) consensus motif; other site 675635006526 putative CoA binding site [chemical binding]; other site 675635006527 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 675635006528 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635006529 acyl-activating enzyme (AAE) consensus motif; other site 675635006530 AMP binding site [chemical binding]; other site 675635006531 active site 675635006532 CoA binding site [chemical binding]; other site 675635006533 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 675635006534 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 675635006535 active site 675635006536 dimer interface [polypeptide binding]; other site 675635006537 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635006538 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 675635006539 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 675635006540 catalytic triad [active] 675635006541 Predicted amidohydrolase [General function prediction only]; Region: COG0388 675635006542 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 675635006543 putative active site [active] 675635006544 catalytic triad [active] 675635006545 putative dimer interface [polypeptide binding]; other site 675635006546 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 675635006547 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 675635006548 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 675635006549 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635006550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635006551 DNA-binding site [nucleotide binding]; DNA binding site 675635006552 FCD domain; Region: FCD; pfam07729 675635006553 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 675635006554 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 675635006555 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 675635006556 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 675635006557 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 675635006558 dimer interface [polypeptide binding]; other site 675635006559 active site 675635006560 glycine-pyridoxal phosphate binding site [chemical binding]; other site 675635006561 folate binding site [chemical binding]; other site 675635006562 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 675635006563 lipoyl attachment site [posttranslational modification]; other site 675635006564 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 675635006565 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 675635006566 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 675635006567 glycine dehydrogenase; Provisional; Region: PRK05367 675635006568 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 675635006569 tetramer interface [polypeptide binding]; other site 675635006570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635006571 catalytic residue [active] 675635006572 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 675635006573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635006574 tetramer interface [polypeptide binding]; other site 675635006575 catalytic residue [active] 675635006576 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 675635006577 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635006578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635006579 Walker A/P-loop; other site 675635006580 ATP binding site [chemical binding]; other site 675635006581 Q-loop/lid; other site 675635006582 ABC transporter signature motif; other site 675635006583 Walker B; other site 675635006584 D-loop; other site 675635006585 H-loop/switch region; other site 675635006586 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 675635006587 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635006588 classical (c) SDRs; Region: SDR_c; cd05233 675635006589 NAD(P) binding site [chemical binding]; other site 675635006590 active site 675635006591 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 675635006592 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635006593 Cytochrome P450; Region: p450; cl12078 675635006594 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635006595 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635006596 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635006597 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635006598 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635006599 catalytic loop [active] 675635006600 iron binding site [ion binding]; other site 675635006601 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635006602 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635006603 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 675635006604 EthD domain; Region: EthD; cl17553 675635006605 SnoaL-like domain; Region: SnoaL_4; pfam13577 675635006606 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635006607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006608 substrate binding site [chemical binding]; other site 675635006609 oxyanion hole (OAH) forming residues; other site 675635006610 trimer interface [polypeptide binding]; other site 675635006611 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 675635006612 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635006613 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 675635006614 acyl-activating enzyme (AAE) consensus motif; other site 675635006615 putative AMP binding site [chemical binding]; other site 675635006616 putative active site [active] 675635006617 putative CoA binding site [chemical binding]; other site 675635006618 hypothetical protein; Provisional; Region: PRK12839 675635006619 CrcB-like protein; Region: CRCB; cl09114 675635006620 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 675635006621 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635006622 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635006623 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635006624 TM-ABC transporter signature motif; other site 675635006625 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635006626 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635006627 TM-ABC transporter signature motif; other site 675635006628 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635006629 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 675635006630 Walker A/P-loop; other site 675635006631 ATP binding site [chemical binding]; other site 675635006632 Q-loop/lid; other site 675635006633 ABC transporter signature motif; other site 675635006634 Walker B; other site 675635006635 D-loop; other site 675635006636 H-loop/switch region; other site 675635006637 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635006638 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 675635006639 Walker A/P-loop; other site 675635006640 ATP binding site [chemical binding]; other site 675635006641 Q-loop/lid; other site 675635006642 ABC transporter signature motif; other site 675635006643 Walker B; other site 675635006644 D-loop; other site 675635006645 H-loop/switch region; other site 675635006646 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 675635006647 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635006648 dimer interface [polypeptide binding]; other site 675635006649 active site 675635006650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006651 NAD(P) binding site [chemical binding]; other site 675635006652 active site 675635006653 enoyl-CoA hydratase; Provisional; Region: PRK08252 675635006654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006655 substrate binding site [chemical binding]; other site 675635006656 oxyanion hole (OAH) forming residues; other site 675635006657 trimer interface [polypeptide binding]; other site 675635006658 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635006659 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635006660 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635006661 active site 675635006662 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635006663 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635006664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635006665 DNA-binding site [nucleotide binding]; DNA binding site 675635006666 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 675635006667 DNA polymerase kappa; Provisional; Region: PTZ00205 675635006668 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635006669 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635006670 lipid-transfer protein; Provisional; Region: PRK07855 675635006671 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635006672 active site 675635006673 Amidohydrolase; Region: Amidohydro_2; pfam04909 675635006674 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 675635006675 iron-sulfur cluster [ion binding]; other site 675635006676 [2Fe-2S] cluster binding site [ion binding]; other site 675635006677 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635006678 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635006679 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635006680 acyl-activating enzyme (AAE) consensus motif; other site 675635006681 acyl-activating enzyme (AAE) consensus motif; other site 675635006682 putative AMP binding site [chemical binding]; other site 675635006683 putative active site [active] 675635006684 putative CoA binding site [chemical binding]; other site 675635006685 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635006686 classical (c) SDRs; Region: SDR_c; cd05233 675635006687 NAD(P) binding site [chemical binding]; other site 675635006688 active site 675635006689 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 675635006690 active site 675635006691 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635006692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006693 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 675635006694 NAD(P) binding site [chemical binding]; other site 675635006695 active site 675635006696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006697 putative substrate translocation pore; other site 675635006698 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635006699 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635006700 Cytochrome P450; Region: p450; cl12078 675635006701 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635006702 Cytochrome P450; Region: p450; cl12078 675635006703 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635006704 classical (c) SDRs; Region: SDR_c; cd05233 675635006705 NAD(P) binding site [chemical binding]; other site 675635006706 active site 675635006707 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635006708 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635006709 active site 675635006710 metal binding site [ion binding]; metal-binding site 675635006711 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 675635006712 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 675635006713 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 675635006714 Predicted oxidoreductase [General function prediction only]; Region: COG3573 675635006715 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635006716 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635006717 NAD(P) binding site [chemical binding]; other site 675635006718 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635006719 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 675635006720 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 675635006721 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635006722 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 675635006723 intersubunit interface [polypeptide binding]; other site 675635006724 active site 675635006725 Zn2+ binding site [ion binding]; other site 675635006726 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 675635006727 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635006728 phosphate binding site [ion binding]; other site 675635006729 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635006730 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635006731 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635006732 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635006733 TM-ABC transporter signature motif; other site 675635006734 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 675635006735 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635006736 TM-ABC transporter signature motif; other site 675635006737 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635006738 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 675635006739 Walker A/P-loop; other site 675635006740 ATP binding site [chemical binding]; other site 675635006741 Q-loop/lid; other site 675635006742 ABC transporter signature motif; other site 675635006743 Walker B; other site 675635006744 D-loop; other site 675635006745 H-loop/switch region; other site 675635006746 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635006747 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 675635006748 Walker A/P-loop; other site 675635006749 ATP binding site [chemical binding]; other site 675635006750 Q-loop/lid; other site 675635006751 ABC transporter signature motif; other site 675635006752 Walker B; other site 675635006753 D-loop; other site 675635006754 H-loop/switch region; other site 675635006755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635006756 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635006757 NAD(P) binding site [chemical binding]; other site 675635006758 active site 675635006759 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 675635006760 classical (c) SDRs; Region: SDR_c; cd05233 675635006761 NAD(P) binding site [chemical binding]; other site 675635006762 active site 675635006763 active site 675635006764 metal binding site [ion binding]; metal-binding site 675635006765 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 675635006766 FAD binding domain; Region: FAD_binding_2; pfam00890 675635006767 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 675635006768 Predicted transcriptional regulators [Transcription]; Region: COG1378 675635006769 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 675635006770 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 675635006771 C-terminal domain interface [polypeptide binding]; other site 675635006772 sugar binding site [chemical binding]; other site 675635006773 AAA ATPase domain; Region: AAA_16; pfam13191 675635006774 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 675635006775 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 675635006776 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 675635006777 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635006778 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635006779 MarR family; Region: MarR_2; pfam12802 675635006780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635006782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635006784 putative substrate translocation pore; other site 675635006785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006786 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 675635006787 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 675635006788 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635006789 Cytochrome P450; Region: p450; cl12078 675635006790 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 675635006791 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635006792 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635006793 acyl-activating enzyme (AAE) consensus motif; other site 675635006794 putative AMP binding site [chemical binding]; other site 675635006795 putative active site [active] 675635006796 putative CoA binding site [chemical binding]; other site 675635006797 benzoate transport; Region: 2A0115; TIGR00895 675635006798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006799 putative substrate translocation pore; other site 675635006800 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635006801 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006802 substrate binding site [chemical binding]; other site 675635006803 oxyanion hole (OAH) forming residues; other site 675635006804 trimer interface [polypeptide binding]; other site 675635006805 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635006806 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635006807 active site 675635006808 non-prolyl cis peptide bond; other site 675635006809 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635006810 active site 675635006811 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 675635006812 dimer interface [polypeptide binding]; other site 675635006813 non-prolyl cis peptide bond; other site 675635006814 insertion regions; other site 675635006815 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 675635006816 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 675635006817 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 675635006818 inhibitor site; inhibition site 675635006819 active site 675635006820 dimer interface [polypeptide binding]; other site 675635006821 catalytic residue [active] 675635006822 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635006823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635006824 DNA-binding site [nucleotide binding]; DNA binding site 675635006825 FCD domain; Region: FCD; pfam07729 675635006826 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635006827 MarR family; Region: MarR_2; pfam12802 675635006828 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635006829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 675635006830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635006831 Walker A/P-loop; other site 675635006832 ATP binding site [chemical binding]; other site 675635006833 Q-loop/lid; other site 675635006834 ABC transporter signature motif; other site 675635006835 Walker B; other site 675635006836 D-loop; other site 675635006837 H-loop/switch region; other site 675635006838 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 675635006839 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 675635006840 active site 675635006841 DNA binding site [nucleotide binding] 675635006842 Int/Topo IB signature motif; other site 675635006843 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 675635006844 intracellular protease, PfpI family; Region: PfpI; TIGR01382 675635006845 proposed catalytic triad [active] 675635006846 conserved cys residue [active] 675635006847 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 675635006848 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635006849 dimer interface [polypeptide binding]; other site 675635006850 active site 675635006851 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 675635006852 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 675635006853 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 675635006854 active site 675635006855 catalytic site [active] 675635006856 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 675635006857 Fe-S cluster binding site [ion binding]; other site 675635006858 active site 675635006859 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635006860 Protein kinase domain; Region: Pkinase; pfam00069 675635006861 active site 675635006862 ATP binding site [chemical binding]; other site 675635006863 substrate binding site [chemical binding]; other site 675635006864 activation loop (A-loop); other site 675635006865 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 675635006866 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635006867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635006868 LysR substrate binding domain; Region: LysR_substrate; pfam03466 675635006869 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635006870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635006871 Walker A motif; other site 675635006872 ATP binding site [chemical binding]; other site 675635006873 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 675635006874 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 675635006875 metal ion-dependent adhesion site (MIDAS); other site 675635006876 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 675635006877 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 675635006878 putative hydrophobic ligand binding site [chemical binding]; other site 675635006879 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 675635006880 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635006881 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635006882 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635006883 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635006884 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635006885 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 675635006886 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635006887 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 675635006888 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 675635006889 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635006890 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 675635006891 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 675635006892 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635006893 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 675635006894 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 675635006895 XdhC Rossmann domain; Region: XdhC_C; pfam13478 675635006896 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 675635006897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635006899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635006900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006901 putative substrate translocation pore; other site 675635006902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006904 putative substrate translocation pore; other site 675635006905 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 675635006906 active site 675635006907 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 675635006908 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 675635006909 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635006910 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635006911 GAF domain; Region: GAF; pfam01590 675635006912 GAF domain; Region: GAF_2; pfam13185 675635006913 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635006914 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635006915 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635006916 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635006917 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635006918 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 675635006919 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635006920 classical (c) SDRs; Region: SDR_c; cd05233 675635006921 NAD(P) binding site [chemical binding]; other site 675635006922 active site 675635006923 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635006924 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635006925 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635006926 acyl-activating enzyme (AAE) consensus motif; other site 675635006927 putative AMP binding site [chemical binding]; other site 675635006928 putative active site [active] 675635006929 putative CoA binding site [chemical binding]; other site 675635006930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635006932 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635006933 classical (c) SDRs; Region: SDR_c; cd05233 675635006934 NAD(P) binding site [chemical binding]; other site 675635006935 active site 675635006936 classical (c) SDRs; Region: SDR_c; cd05233 675635006937 NAD(P) binding site [chemical binding]; other site 675635006938 active site 675635006939 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635006940 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635006941 substrate binding site [chemical binding]; other site 675635006942 oxyanion hole (OAH) forming residues; other site 675635006943 trimer interface [polypeptide binding]; other site 675635006944 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635006945 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635006946 Bifunctional nuclease; Region: DNase-RNase; pfam02577 675635006947 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 675635006948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635006949 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635006950 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635006951 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 675635006952 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635006953 catalytic residue [active] 675635006954 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 675635006955 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635006956 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635006957 PGAP1-like protein; Region: PGAP1; pfam07819 675635006958 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 675635006959 short chain dehydrogenase; Provisional; Region: PRK06172 675635006960 classical (c) SDRs; Region: SDR_c; cd05233 675635006961 NAD(P) binding site [chemical binding]; other site 675635006962 active site 675635006963 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 675635006964 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635006965 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 675635006966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635006967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635006968 putative substrate translocation pore; other site 675635006969 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635006970 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635006971 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 675635006972 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 675635006973 catalytic residues [active] 675635006974 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635006975 Cytochrome P450; Region: p450; cl12078 675635006976 Cytochrome P450; Region: p450; cl12078 675635006977 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 675635006978 putative catalytic site [active] 675635006979 putative metal binding site [ion binding]; other site 675635006980 putative phosphate binding site [ion binding]; other site 675635006981 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 675635006982 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 675635006983 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635006984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635006985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635006986 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635006987 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 675635006988 acyl-activating enzyme (AAE) consensus motif; other site 675635006989 AMP binding site [chemical binding]; other site 675635006990 active site 675635006991 CoA binding site [chemical binding]; other site 675635006992 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 675635006993 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 675635006994 substrate binding site [chemical binding]; other site 675635006995 dimer interface [polypeptide binding]; other site 675635006996 NADP binding site [chemical binding]; other site 675635006997 catalytic residues [active] 675635006998 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635006999 active site 2 [active] 675635007000 active site 1 [active] 675635007001 enoyl-CoA hydratase; Provisional; Region: PRK06688 675635007002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635007003 substrate binding site [chemical binding]; other site 675635007004 oxyanion hole (OAH) forming residues; other site 675635007005 trimer interface [polypeptide binding]; other site 675635007006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635007007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635007008 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 675635007009 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 675635007010 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 675635007011 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 675635007012 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 675635007013 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 675635007014 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 675635007015 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 675635007016 FAD binding pocket [chemical binding]; other site 675635007017 FAD binding motif [chemical binding]; other site 675635007018 phosphate binding motif [ion binding]; other site 675635007019 beta-alpha-beta structure motif; other site 675635007020 NAD(p) ribose binding residues [chemical binding]; other site 675635007021 NAD binding pocket [chemical binding]; other site 675635007022 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 675635007023 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635007024 catalytic loop [active] 675635007025 iron binding site [ion binding]; other site 675635007026 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 675635007027 active site 675635007028 catalytic residues [active] 675635007029 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 675635007030 active site 675635007031 SAM binding site [chemical binding]; other site 675635007032 homodimer interface [polypeptide binding]; other site 675635007033 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 675635007034 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 675635007035 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635007036 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 675635007037 ATP binding site [chemical binding]; other site 675635007038 Mg2+ binding site [ion binding]; other site 675635007039 G-X-G motif; other site 675635007040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635007041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635007042 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 675635007043 metal binding site 2 [ion binding]; metal-binding site 675635007044 putative DNA binding helix; other site 675635007045 metal binding site 1 [ion binding]; metal-binding site 675635007046 dimer interface [polypeptide binding]; other site 675635007047 structural Zn2+ binding site [ion binding]; other site 675635007048 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 675635007049 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 675635007050 heme binding site [chemical binding]; other site 675635007051 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 675635007052 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 675635007053 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 675635007054 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 675635007055 active site 675635007056 acyl-activating enzyme (AAE) consensus motif; other site 675635007057 putative CoA binding site [chemical binding]; other site 675635007058 AMP binding site [chemical binding]; other site 675635007059 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635007060 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 675635007061 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 675635007062 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 675635007063 cobyric acid synthase; Provisional; Region: PRK00784 675635007064 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 675635007065 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 675635007066 catalytic triad [active] 675635007067 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 675635007068 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 675635007069 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 675635007070 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 675635007071 metal ion-dependent adhesion site (MIDAS); other site 675635007072 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 675635007073 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 675635007074 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 675635007075 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 675635007076 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 675635007077 catalytic triad [active] 675635007078 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 675635007079 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 675635007080 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 675635007081 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 675635007082 homodimer interface [polypeptide binding]; other site 675635007083 active site 675635007084 SAM binding site [chemical binding]; other site 675635007085 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635007086 FMN binding site [chemical binding]; other site 675635007087 dimer interface [polypeptide binding]; other site 675635007088 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 675635007089 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 675635007090 putative dimer interface [polypeptide binding]; other site 675635007091 active site pocket [active] 675635007092 putative cataytic base [active] 675635007093 DNA polymerase IV; Provisional; Region: PRK03348 675635007094 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 675635007095 active site 675635007096 DNA binding site [nucleotide binding] 675635007097 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 675635007098 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 675635007099 catalytic residues [active] 675635007100 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 675635007101 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635007102 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635007103 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635007104 active site 675635007105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635007106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635007107 hypothetical protein; Provisional; Region: PRK06834 675635007108 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635007109 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 675635007110 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 675635007111 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 675635007112 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635007113 Cytochrome P450; Region: p450; cl12078 675635007114 Cytochrome P450; Region: p450; cl12078 675635007115 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 675635007116 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 675635007117 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 675635007118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635007119 motif II; other site 675635007120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635007121 sequence-specific DNA binding site [nucleotide binding]; other site 675635007122 salt bridge; other site 675635007123 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635007124 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 675635007125 tetramer interface [polypeptide binding]; other site 675635007126 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 675635007127 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635007128 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635007129 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 675635007130 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 675635007131 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 675635007132 conserved cys residue [active] 675635007133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635007134 ferredoxin-NADP+ reductase; Region: PLN02852 675635007135 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635007136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635007137 DNA-binding site [nucleotide binding]; DNA binding site 675635007138 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 675635007139 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 675635007140 heme bH binding site [chemical binding]; other site 675635007141 intrachain domain interface; other site 675635007142 heme bL binding site [chemical binding]; other site 675635007143 interchain domain interface [polypeptide binding]; other site 675635007144 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 675635007145 Qo binding site; other site 675635007146 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 675635007147 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 675635007148 iron-sulfur cluster [ion binding]; other site 675635007149 [2Fe-2S] cluster binding site [ion binding]; other site 675635007150 Cytochrome c; Region: Cytochrom_C; cl11414 675635007151 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 675635007152 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 675635007153 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 675635007154 Subunit I/III interface [polypeptide binding]; other site 675635007155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 675635007156 active site 675635007157 phosphorylation site [posttranslational modification] 675635007158 intermolecular recognition site; other site 675635007159 dimerization interface [polypeptide binding]; other site 675635007160 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 675635007161 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 675635007162 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 675635007163 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635007164 AsnC family; Region: AsnC_trans_reg; pfam01037 675635007165 hypothetical protein; Validated; Region: PRK07883 675635007166 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 675635007167 active site 675635007168 catalytic site [active] 675635007169 substrate binding site [chemical binding]; other site 675635007170 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 675635007171 GIY-YIG motif/motif A; other site 675635007172 active site 675635007173 catalytic site [active] 675635007174 putative DNA binding site [nucleotide binding]; other site 675635007175 metal binding site [ion binding]; metal-binding site 675635007176 YacP-like NYN domain; Region: NYN_YacP; cl01491 675635007177 NlpC/P60 family; Region: NLPC_P60; pfam00877 675635007178 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635007179 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635007180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635007181 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 675635007182 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 675635007183 acyl-activating enzyme (AAE) consensus motif; other site 675635007184 putative AMP binding site [chemical binding]; other site 675635007185 putative active site [active] 675635007186 putative CoA binding site [chemical binding]; other site 675635007187 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 675635007188 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 675635007189 active site 675635007190 metal binding site [ion binding]; metal-binding site 675635007191 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 675635007192 putative hydrophobic ligand binding site [chemical binding]; other site 675635007193 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 675635007194 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 675635007195 P loop; other site 675635007196 Nucleotide binding site [chemical binding]; other site 675635007197 DTAP/Switch II; other site 675635007198 Switch I; other site 675635007199 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 675635007200 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 675635007201 nucleotide binding site [chemical binding]; other site 675635007202 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 675635007203 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635007204 putative acyl-acceptor binding pocket; other site 675635007205 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 675635007206 Protein kinase domain; Region: Pkinase; pfam00069 675635007207 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635007208 active site 675635007209 ATP binding site [chemical binding]; other site 675635007210 substrate binding site [chemical binding]; other site 675635007211 activation loop (A-loop); other site 675635007212 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635007213 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635007214 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 675635007215 substrate binding pocket [chemical binding]; other site 675635007216 substrate-Mg2+ binding site; other site 675635007217 aspartate-rich region 1; other site 675635007218 aspartate-rich region 2; other site 675635007219 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 675635007220 phytoene desaturase; Region: crtI_fam; TIGR02734 675635007221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 675635007222 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 675635007223 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 675635007224 substrate binding pocket [chemical binding]; other site 675635007225 chain length determination region; other site 675635007226 substrate-Mg2+ binding site; other site 675635007227 catalytic residues [active] 675635007228 aspartate-rich region 1; other site 675635007229 active site lid residues [active] 675635007230 aspartate-rich region 2; other site 675635007231 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 675635007232 FAD binding site [chemical binding]; other site 675635007233 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 675635007234 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 675635007235 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635007236 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635007237 P-loop; other site 675635007238 Magnesium ion binding site [ion binding]; other site 675635007239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635007240 Magnesium ion binding site [ion binding]; other site 675635007241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635007242 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 675635007243 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 675635007244 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 675635007245 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 675635007246 Protein of unknown function DUF58; Region: DUF58; pfam01882 675635007247 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635007248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635007249 ATP binding site [chemical binding]; other site 675635007250 Walker A motif; other site 675635007251 Walker B motif; other site 675635007252 arginine finger; other site 675635007253 cell division protein MraZ; Reviewed; Region: PRK00326 675635007254 MraZ protein; Region: MraZ; pfam02381 675635007255 MraZ protein; Region: MraZ; pfam02381 675635007256 MraW methylase family; Region: Methyltransf_5; cl17771 675635007257 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 675635007258 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 675635007259 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 675635007260 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 675635007261 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 675635007262 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635007263 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 675635007264 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 675635007265 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635007266 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 675635007267 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 675635007268 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 675635007269 Mg++ binding site [ion binding]; other site 675635007270 putative catalytic motif [active] 675635007271 putative substrate binding site [chemical binding]; other site 675635007272 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 675635007273 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635007274 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 675635007275 cell division protein FtsW; Region: ftsW; TIGR02614 675635007276 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 675635007277 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 675635007278 homodimer interface [polypeptide binding]; other site 675635007279 active site 675635007280 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 675635007281 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 675635007282 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 675635007283 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 675635007284 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 675635007285 Cell division protein FtsQ; Region: FtsQ; pfam03799 675635007286 cell division protein FtsZ; Validated; Region: PRK09330 675635007287 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 675635007288 nucleotide binding site [chemical binding]; other site 675635007289 SulA interaction site; other site 675635007290 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 675635007291 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 675635007292 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 675635007293 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635007294 catalytic residue [active] 675635007295 Protein of unknown function (DUF552); Region: DUF552; pfam04472 675635007296 Predicted integral membrane protein [Function unknown]; Region: COG0762 675635007297 DivIVA domain; Region: DivI1A_domain; TIGR03544 675635007298 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 675635007299 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 675635007300 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 675635007301 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 675635007302 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 675635007303 HIGH motif; other site 675635007304 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 675635007305 active site 675635007306 KMSKS motif; other site 675635007307 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 675635007308 tRNA binding surface [nucleotide binding]; other site 675635007309 anticodon binding site; other site 675635007310 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635007311 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 675635007312 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 675635007313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635007314 S-adenosylmethionine binding site [chemical binding]; other site 675635007315 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 675635007316 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635007317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 675635007318 active site 675635007319 phosphorylation site [posttranslational modification] 675635007320 intermolecular recognition site; other site 675635007321 dimerization interface [polypeptide binding]; other site 675635007322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635007323 DNA binding residues [nucleotide binding] 675635007324 Putative sensor; Region: Sensor; pfam13796 675635007325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635007326 Histidine kinase; Region: HisKA_3; pfam07730 675635007327 CAAX protease self-immunity; Region: Abi; pfam02517 675635007328 Acyltransferase family; Region: Acyl_transf_3; pfam01757 675635007329 potassium/proton antiporter; Reviewed; Region: PRK05326 675635007330 TrkA-C domain; Region: TrkA_C; pfam02080 675635007331 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 675635007332 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 675635007333 RNA binding surface [nucleotide binding]; other site 675635007334 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 675635007335 active site 675635007336 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635007337 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635007338 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 675635007339 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 675635007340 active site 675635007341 PHP Thumb interface [polypeptide binding]; other site 675635007342 metal binding site [ion binding]; metal-binding site 675635007343 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 675635007344 generic binding surface II; other site 675635007345 generic binding surface I; other site 675635007346 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 675635007347 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635007348 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635007349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635007350 putative substrate translocation pore; other site 675635007351 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 675635007352 PaaX-like protein; Region: PaaX; pfam07848 675635007353 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 675635007354 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635007355 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 675635007356 inhibitor-cofactor binding pocket; inhibition site 675635007357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635007358 catalytic residue [active] 675635007359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635007360 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 675635007361 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 675635007362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635007363 catalytic residue [active] 675635007364 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 675635007365 biotin synthase; Validated; Region: PRK06256 675635007366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635007367 FeS/SAM binding site; other site 675635007368 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 675635007369 PemK-like protein; Region: PemK; pfam02452 675635007370 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 675635007371 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 675635007372 nudix motif; other site 675635007373 quinolinate synthetase; Provisional; Region: PRK09375 675635007374 L-aspartate oxidase; Provisional; Region: PRK07804 675635007375 L-aspartate oxidase; Provisional; Region: PRK06175 675635007376 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 675635007377 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 675635007378 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 675635007379 dimerization interface [polypeptide binding]; other site 675635007380 active site 675635007381 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 675635007382 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 675635007383 NAD binding site [chemical binding]; other site 675635007384 dimerization interface [polypeptide binding]; other site 675635007385 product binding site; other site 675635007386 substrate binding site [chemical binding]; other site 675635007387 zinc binding site [ion binding]; other site 675635007388 catalytic residues [active] 675635007389 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 675635007390 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635007391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635007392 homodimer interface [polypeptide binding]; other site 675635007393 catalytic residue [active] 675635007394 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 675635007395 putative active site pocket [active] 675635007396 4-fold oligomerization interface [polypeptide binding]; other site 675635007397 metal binding residues [ion binding]; metal-binding site 675635007398 3-fold/trimer interface [polypeptide binding]; other site 675635007399 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 675635007400 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 675635007401 putative active site [active] 675635007402 oxyanion strand; other site 675635007403 catalytic triad [active] 675635007404 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635007405 substrate binding site [chemical binding]; other site 675635007406 THF binding site; other site 675635007407 zinc-binding site [ion binding]; other site 675635007408 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 675635007409 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 675635007410 catalytic residues [active] 675635007411 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 675635007412 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 675635007413 substrate binding site [chemical binding]; other site 675635007414 glutamase interaction surface [polypeptide binding]; other site 675635007415 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 675635007416 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 675635007417 Histidine kinase; Region: HisKA_3; pfam07730 675635007418 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 675635007419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635007420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635007421 active site 675635007422 phosphorylation site [posttranslational modification] 675635007423 intermolecular recognition site; other site 675635007424 dimerization interface [polypeptide binding]; other site 675635007425 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635007426 DNA binding residues [nucleotide binding] 675635007427 dimerization interface [polypeptide binding]; other site 675635007428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635007429 anthranilate synthase component I; Provisional; Region: PRK13571 675635007430 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 675635007431 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 675635007432 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 675635007433 active site 675635007434 ribulose/triose binding site [chemical binding]; other site 675635007435 phosphate binding site [ion binding]; other site 675635007436 substrate (anthranilate) binding pocket [chemical binding]; other site 675635007437 product (indole) binding pocket [chemical binding]; other site 675635007438 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 675635007439 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 675635007440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635007441 catalytic residue [active] 675635007442 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 675635007443 substrate binding site [chemical binding]; other site 675635007444 active site 675635007445 catalytic residues [active] 675635007446 heterodimer interface [polypeptide binding]; other site 675635007447 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 675635007448 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 675635007449 pyruvate kinase; Provisional; Region: PRK06247 675635007450 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 675635007451 domain interfaces; other site 675635007452 active site 675635007453 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 675635007454 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 675635007455 active site 675635007456 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 675635007457 catalytic triad [active] 675635007458 dimer interface [polypeptide binding]; other site 675635007459 OsmC-like protein; Region: OsmC; pfam02566 675635007460 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 675635007461 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 675635007462 homodimer interface [polypeptide binding]; other site 675635007463 substrate-cofactor binding pocket; other site 675635007464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635007465 catalytic residue [active] 675635007466 CoA binding domain; Region: CoA_binding; cl17356 675635007467 malate dehydrogenase; Provisional; Region: PRK05442 675635007468 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 675635007469 NAD(P) binding site [chemical binding]; other site 675635007470 dimer interface [polypeptide binding]; other site 675635007471 malate binding site [chemical binding]; other site 675635007472 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 675635007473 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 675635007474 putative active site [active] 675635007475 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 675635007476 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 675635007477 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 675635007478 catalytic site [active] 675635007479 active site 675635007480 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 675635007481 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 675635007482 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 675635007483 active site 675635007484 catalytic site [active] 675635007485 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 675635007486 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 675635007487 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 675635007488 active site 675635007489 catalytic site [active] 675635007490 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 675635007491 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 675635007492 nucleotide binding site/active site [active] 675635007493 HIT family signature motif; other site 675635007494 catalytic residue [active] 675635007495 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635007496 catalytic core [active] 675635007497 H+ Antiporter protein; Region: 2A0121; TIGR00900 675635007498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635007499 transcription termination factor Rho; Provisional; Region: PRK12678 675635007500 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 675635007501 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635007502 metal binding site [ion binding]; metal-binding site 675635007503 active site 675635007504 I-site; other site 675635007505 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 675635007506 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635007507 metal binding site [ion binding]; metal-binding site 675635007508 active site 675635007509 I-site; other site 675635007510 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 675635007511 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 675635007512 TPP-binding site; other site 675635007513 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 675635007514 PYR/PP interface [polypeptide binding]; other site 675635007515 dimer interface [polypeptide binding]; other site 675635007516 TPP binding site [chemical binding]; other site 675635007517 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635007518 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635007519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635007520 active site 675635007521 phosphorylation site [posttranslational modification] 675635007522 intermolecular recognition site; other site 675635007523 dimerization interface [polypeptide binding]; other site 675635007524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635007525 DNA binding site [nucleotide binding] 675635007526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635007527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 675635007528 dimerization interface [polypeptide binding]; other site 675635007529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635007530 dimer interface [polypeptide binding]; other site 675635007531 phosphorylation site [posttranslational modification] 675635007532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635007533 ATP binding site [chemical binding]; other site 675635007534 Mg2+ binding site [ion binding]; other site 675635007535 G-X-G motif; other site 675635007536 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 675635007537 catalytic site [active] 675635007538 putative active site [active] 675635007539 putative substrate binding site [chemical binding]; other site 675635007540 HRDC domain; Region: HRDC; cl02578 675635007541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635007542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635007543 active site 675635007544 phosphorylation site [posttranslational modification] 675635007545 intermolecular recognition site; other site 675635007546 dimerization interface [polypeptide binding]; other site 675635007547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635007548 DNA binding residues [nucleotide binding] 675635007549 dimerization interface [polypeptide binding]; other site 675635007550 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 675635007551 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 675635007552 substrate binding site [chemical binding]; other site 675635007553 active site 675635007554 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 675635007555 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 675635007556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635007557 dimerization interface [polypeptide binding]; other site 675635007558 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 675635007559 SelR domain; Region: SelR; pfam01641 675635007560 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 675635007561 nucleotide binding site [chemical binding]; other site 675635007562 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635007563 Asp23 family; Region: Asp23; cl00574 675635007564 Small T antigen; Reviewed; Region: PHA03102 675635007565 Asp23 family; Region: Asp23; pfam03780 675635007566 hypothetical protein; Provisional; Region: PRK14059 675635007567 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 675635007568 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 675635007569 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 675635007570 ABC-ATPase subunit interface; other site 675635007571 dimer interface [polypeptide binding]; other site 675635007572 putative PBP binding regions; other site 675635007573 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 675635007574 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 675635007575 dimer interface [polypeptide binding]; other site 675635007576 putative PBP binding regions; other site 675635007577 ABC-ATPase subunit interface; other site 675635007578 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 675635007579 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 675635007580 Walker A/P-loop; other site 675635007581 ATP binding site [chemical binding]; other site 675635007582 Q-loop/lid; other site 675635007583 ABC transporter signature motif; other site 675635007584 Walker B; other site 675635007585 D-loop; other site 675635007586 H-loop/switch region; other site 675635007587 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 675635007588 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 675635007589 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 675635007590 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635007591 FAD binding domain; Region: FAD_binding_4; pfam01565 675635007592 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 675635007593 Methyltransferase domain; Region: Methyltransf_12; pfam08242 675635007594 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 675635007595 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 675635007596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 675635007597 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 675635007598 acyl-CoA synthetase; Validated; Region: PRK07798 675635007599 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635007600 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635007601 acyl-activating enzyme (AAE) consensus motif; other site 675635007602 acyl-activating enzyme (AAE) consensus motif; other site 675635007603 AMP binding site [chemical binding]; other site 675635007604 active site 675635007605 CoA binding site [chemical binding]; other site 675635007606 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 675635007607 active site 675635007608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007609 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635007610 NAD(P) binding site [chemical binding]; other site 675635007611 active site 675635007612 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635007613 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635007614 active site 675635007615 enoyl-CoA hydratase; Region: PLN02864 675635007616 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 675635007617 active site 2 [active] 675635007618 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 675635007619 dimer interaction site [polypeptide binding]; other site 675635007620 substrate-binding tunnel; other site 675635007621 active site 675635007622 catalytic site [active] 675635007623 substrate binding site [chemical binding]; other site 675635007624 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635007625 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635007626 Phosphotransferase enzyme family; Region: APH; pfam01636 675635007627 Fructosamine kinase; Region: Fructosamin_kin; cl17579 675635007628 Low molecular weight phosphatase family; Region: LMWPc; cd00115 675635007629 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 675635007630 active site 675635007631 hypothetical protein; Provisional; Region: PRK07908 675635007632 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635007633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635007634 catalytic residue [active] 675635007635 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635007636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635007637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635007638 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635007639 Uncharacterized conserved protein [Function unknown]; Region: COG0327 675635007640 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 675635007641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 675635007642 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 675635007643 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 675635007644 Putative zinc ribbon domain; Region: DUF164; pfam02591 675635007645 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 675635007646 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635007647 catalytic core [active] 675635007648 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 675635007649 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 675635007650 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 675635007651 Domain of unknown function (DUF222); Region: DUF222; pfam02720 675635007652 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 675635007653 active site 675635007654 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 675635007655 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 675635007656 putative active site [active] 675635007657 putative NTP binding site [chemical binding]; other site 675635007658 putative nucleic acid binding site [nucleotide binding]; other site 675635007659 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635007660 active site 675635007661 catalytic triad [active] 675635007662 oxyanion hole [active] 675635007663 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 675635007664 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635007665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635007666 DNA-binding site [nucleotide binding]; DNA binding site 675635007667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635007668 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 675635007669 hypothetical protein; Provisional; Region: PRK07236 675635007670 hypothetical protein; Provisional; Region: PRK07588 675635007671 phosphoenolpyruvate synthase; Validated; Region: PRK06241 675635007672 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 675635007673 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 675635007674 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 675635007675 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 675635007676 G1 box; other site 675635007677 GTP/Mg2+ binding site [chemical binding]; other site 675635007678 G2 box; other site 675635007679 Switch I region; other site 675635007680 G3 box; other site 675635007681 Switch II region; other site 675635007682 G4 box; other site 675635007683 G5 box; other site 675635007684 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 675635007685 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635007686 active site 675635007687 catalytic triad [active] 675635007688 oxyanion hole [active] 675635007689 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 675635007690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635007691 motif II; other site 675635007692 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635007693 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635007694 active site 675635007695 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 675635007696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635007697 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 675635007698 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635007699 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635007700 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 675635007701 putative hydrophobic ligand binding site [chemical binding]; other site 675635007702 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635007703 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635007704 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635007705 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635007706 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 675635007707 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635007708 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 675635007709 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635007710 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635007711 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 675635007712 Walker A/P-loop; other site 675635007713 ATP binding site [chemical binding]; other site 675635007714 Q-loop/lid; other site 675635007715 ABC transporter signature motif; other site 675635007716 Walker B; other site 675635007717 D-loop; other site 675635007718 H-loop/switch region; other site 675635007719 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 675635007720 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635007721 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635007722 TM-ABC transporter signature motif; other site 675635007723 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635007724 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635007725 ligand binding site [chemical binding]; other site 675635007726 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635007727 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 675635007728 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635007729 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635007730 catalytic loop [active] 675635007731 iron binding site [ion binding]; other site 675635007732 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635007733 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635007734 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635007735 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635007736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635007737 NAD(P) binding site [chemical binding]; other site 675635007738 active site 675635007739 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 675635007740 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 675635007741 amidase; Provisional; Region: PRK07486 675635007742 Amidase; Region: Amidase; pfam01425 675635007743 Creatinine amidohydrolase; Region: Creatininase; pfam02633 675635007744 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635007745 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 675635007746 [2Fe-2S] cluster binding site [ion binding]; other site 675635007747 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635007748 hydrophobic ligand binding site; other site 675635007749 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 675635007750 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 675635007751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 675635007752 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635007753 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635007754 AAA ATPase domain; Region: AAA_16; pfam13191 675635007755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635007756 DNA binding residues [nucleotide binding] 675635007757 dimerization interface [polypeptide binding]; other site 675635007758 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 675635007759 active site 675635007760 catalytic tetrad [active] 675635007761 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635007762 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635007763 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635007764 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 675635007765 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 675635007766 DAK2 domain; Region: Dak2; cl03685 675635007767 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 675635007768 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 675635007769 dimerization domain swap beta strand [polypeptide binding]; other site 675635007770 regulatory protein interface [polypeptide binding]; other site 675635007771 active site 675635007772 regulatory phosphorylation site [posttranslational modification]; other site 675635007773 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 675635007774 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 675635007775 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 675635007776 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 675635007777 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 675635007778 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 675635007779 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635007780 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 675635007781 NAD(P) binding site [chemical binding]; other site 675635007782 catalytic residues [active] 675635007783 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 675635007784 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 675635007785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635007786 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635007787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635007788 DNA binding residues [nucleotide binding] 675635007789 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 675635007790 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 675635007791 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 675635007792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635007793 non-specific DNA binding site [nucleotide binding]; other site 675635007794 salt bridge; other site 675635007795 sequence-specific DNA binding site [nucleotide binding]; other site 675635007796 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 675635007797 dimerization interface [polypeptide binding]; other site 675635007798 putative tRNAtyr binding site [nucleotide binding]; other site 675635007799 putative active site [active] 675635007800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635007801 S-adenosylmethionine binding site [chemical binding]; other site 675635007802 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635007803 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635007804 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 675635007805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635007806 dimerization interface [polypeptide binding]; other site 675635007807 putative DNA binding site [nucleotide binding]; other site 675635007808 putative Zn2+ binding site [ion binding]; other site 675635007809 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 675635007810 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 675635007811 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 675635007812 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 675635007813 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 675635007814 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 675635007815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635007816 ATP binding site [chemical binding]; other site 675635007817 putative Mg++ binding site [ion binding]; other site 675635007818 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 675635007819 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635007820 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635007821 catalytic residue [active] 675635007822 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 675635007823 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 675635007824 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 675635007825 putative ligand binding site [chemical binding]; other site 675635007826 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635007827 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 675635007828 Walker A/P-loop; other site 675635007829 ATP binding site [chemical binding]; other site 675635007830 Q-loop/lid; other site 675635007831 ABC transporter signature motif; other site 675635007832 Walker B; other site 675635007833 D-loop; other site 675635007834 H-loop/switch region; other site 675635007835 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 675635007836 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635007837 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635007838 TM-ABC transporter signature motif; other site 675635007839 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 675635007840 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 675635007841 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 675635007842 putative nucleotide binding site [chemical binding]; other site 675635007843 putative catalytic residues [active] 675635007844 putative Mg ion binding site [ion binding]; other site 675635007845 putative aspartate binding site [chemical binding]; other site 675635007846 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 675635007847 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 675635007848 acyl-activating enzyme (AAE) consensus motif; other site 675635007849 AMP binding site [chemical binding]; other site 675635007850 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 675635007851 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 675635007852 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635007853 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635007854 putative trimer interface [polypeptide binding]; other site 675635007855 putative CoA binding site [chemical binding]; other site 675635007856 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 675635007857 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635007858 inhibitor-cofactor binding pocket; inhibition site 675635007859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635007860 catalytic residue [active] 675635007861 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 675635007862 nucleotide binding site [chemical binding]; other site 675635007863 putative NEF/HSP70 interaction site [polypeptide binding]; other site 675635007864 SBD interface [polypeptide binding]; other site 675635007865 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 675635007866 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 675635007867 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 675635007868 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 675635007869 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 675635007870 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 675635007871 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 675635007872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635007873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635007874 active site 675635007875 phosphorylation site [posttranslational modification] 675635007876 intermolecular recognition site; other site 675635007877 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635007878 DNA binding residues [nucleotide binding] 675635007879 dimerization interface [polypeptide binding]; other site 675635007880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635007881 Histidine kinase; Region: HisKA_3; pfam07730 675635007882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635007883 ATP binding site [chemical binding]; other site 675635007884 Mg2+ binding site [ion binding]; other site 675635007885 G-X-G motif; other site 675635007886 Acyltransferase family; Region: Acyl_transf_3; pfam01757 675635007887 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 675635007888 NMT1/THI5 like; Region: NMT1; pfam09084 675635007889 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 675635007890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635007891 ABC-ATPase subunit interface; other site 675635007892 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 675635007893 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 675635007894 Walker A/P-loop; other site 675635007895 ATP binding site [chemical binding]; other site 675635007896 Q-loop/lid; other site 675635007897 ABC transporter signature motif; other site 675635007898 Walker B; other site 675635007899 D-loop; other site 675635007900 H-loop/switch region; other site 675635007901 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 675635007902 active site 675635007903 putative homodimer interface [polypeptide binding]; other site 675635007904 SAM binding site [chemical binding]; other site 675635007905 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 675635007906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635007907 S-adenosylmethionine binding site [chemical binding]; other site 675635007908 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 675635007909 active site 675635007910 SAM binding site [chemical binding]; other site 675635007911 homodimer interface [polypeptide binding]; other site 675635007912 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 675635007913 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 675635007914 active site 675635007915 SAM binding site [chemical binding]; other site 675635007916 homodimer interface [polypeptide binding]; other site 675635007917 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 675635007918 active site 675635007919 SAM binding site [chemical binding]; other site 675635007920 homodimer interface [polypeptide binding]; other site 675635007921 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 675635007922 Precorrin-8X methylmutase; Region: CbiC; pfam02570 675635007923 precorrin-3B synthase; Region: CobG; TIGR02435 675635007924 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 675635007925 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 675635007926 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 675635007927 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 675635007928 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635007929 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 675635007930 active site 675635007931 dimer interface [polypeptide binding]; other site 675635007932 metal binding site [ion binding]; metal-binding site 675635007933 phenylhydantoinase; Validated; Region: PRK08323 675635007934 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635007935 active site 675635007936 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635007937 TM-ABC transporter signature motif; other site 675635007938 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635007939 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 675635007940 Walker A/P-loop; other site 675635007941 ATP binding site [chemical binding]; other site 675635007942 Q-loop/lid; other site 675635007943 ABC transporter signature motif; other site 675635007944 Walker B; other site 675635007945 D-loop; other site 675635007946 H-loop/switch region; other site 675635007947 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 675635007948 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635007949 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635007950 ligand binding site [chemical binding]; other site 675635007951 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635007952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635007953 DNA-binding site [nucleotide binding]; DNA binding site 675635007954 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 675635007955 phenylhydantoinase; Validated; Region: PRK08323 675635007956 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635007957 active site 675635007958 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635007959 Amidase; Region: Amidase; cl11426 675635007960 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635007961 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635007962 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635007963 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 675635007964 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635007965 carboxyltransferase (CT) interaction site; other site 675635007966 biotinylation site [posttranslational modification]; other site 675635007967 oxaloacetate decarboxylase; Provisional; Region: PRK14041 675635007968 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 675635007969 active site 675635007970 catalytic residues [active] 675635007971 metal binding site [ion binding]; metal-binding site 675635007972 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 675635007973 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 675635007974 Coenzyme A transferase; Region: CoA_trans; cl17247 675635007975 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 675635007976 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 675635007977 metal binding site [ion binding]; metal-binding site 675635007978 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 675635007979 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 675635007980 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 675635007981 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 675635007982 dimer interface [polypeptide binding]; other site 675635007983 putative PBP binding regions; other site 675635007984 ABC-ATPase subunit interface; other site 675635007985 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 675635007986 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 675635007987 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 675635007988 FeoA domain; Region: FeoA; pfam04023 675635007989 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 675635007990 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 675635007991 putative dimer interface [polypeptide binding]; other site 675635007992 [2Fe-2S] cluster binding site [ion binding]; other site 675635007993 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 675635007994 putative dimer interface [polypeptide binding]; other site 675635007995 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 675635007996 SLBB domain; Region: SLBB; pfam10531 675635007997 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 675635007998 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 675635007999 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635008000 catalytic loop [active] 675635008001 iron binding site [ion binding]; other site 675635008002 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 675635008003 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 675635008004 [4Fe-4S] binding site [ion binding]; other site 675635008005 molybdopterin cofactor binding site; other site 675635008006 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 675635008007 molybdopterin cofactor binding site; other site 675635008008 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 675635008009 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635008010 MarR family; Region: MarR_2; cl17246 675635008011 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635008012 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 675635008013 putative ligand binding site [chemical binding]; other site 675635008014 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 675635008015 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 675635008016 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 675635008017 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 675635008018 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635008019 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635008020 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635008021 DNA binding residues [nucleotide binding] 675635008022 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 675635008023 active site 675635008024 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 675635008025 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635008026 Phosphotransferase enzyme family; Region: APH; pfam01636 675635008027 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 675635008028 putative active site [active] 675635008029 putative substrate binding site [chemical binding]; other site 675635008030 ATP binding site [chemical binding]; other site 675635008031 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 675635008032 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 675635008033 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 675635008034 trimer interface [polypeptide binding]; other site 675635008035 active site 675635008036 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 675635008037 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 675635008038 generic binding surface II; other site 675635008039 ssDNA binding site; other site 675635008040 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 675635008041 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 675635008042 TrkA-N domain; Region: TrkA_N; pfam02254 675635008043 TrkA-C domain; Region: TrkA_C; pfam02080 675635008044 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 675635008045 TrkA-N domain; Region: TrkA_N; pfam02254 675635008046 TrkA-C domain; Region: TrkA_C; pfam02080 675635008047 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 675635008048 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 675635008049 TRAM domain; Region: TRAM; cl01282 675635008050 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635008051 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635008052 active site 2 [active] 675635008053 active site 1 [active] 675635008054 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 675635008055 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 675635008056 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 675635008057 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 675635008058 RNA binding site [nucleotide binding]; other site 675635008059 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 675635008060 DEAD-like helicases superfamily; Region: DEXDc; smart00487 675635008061 ATP binding site [chemical binding]; other site 675635008062 Mg++ binding site [ion binding]; other site 675635008063 motif III; other site 675635008064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635008065 nucleotide binding region [chemical binding]; other site 675635008066 ATP-binding site [chemical binding]; other site 675635008067 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 675635008068 RNA binding site [nucleotide binding]; other site 675635008069 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 675635008070 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 675635008071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008072 putative substrate translocation pore; other site 675635008073 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 675635008074 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 675635008075 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635008076 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 675635008077 putative DNA binding site [nucleotide binding]; other site 675635008078 putative Zn2+ binding site [ion binding]; other site 675635008079 AsnC family; Region: AsnC_trans_reg; pfam01037 675635008080 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 675635008081 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635008082 tetramer interface [polypeptide binding]; other site 675635008083 TPP-binding site [chemical binding]; other site 675635008084 heterodimer interface [polypeptide binding]; other site 675635008085 phosphorylation loop region [posttranslational modification] 675635008086 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635008087 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 675635008088 alpha subunit interface [polypeptide binding]; other site 675635008089 TPP binding site [chemical binding]; other site 675635008090 heterodimer interface [polypeptide binding]; other site 675635008091 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635008092 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635008093 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 675635008094 E3 interaction surface; other site 675635008095 lipoyl attachment site [posttranslational modification]; other site 675635008096 e3 binding domain; Region: E3_binding; pfam02817 675635008097 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 675635008098 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635008099 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 675635008100 SnoaL-like domain; Region: SnoaL_3; pfam13474 675635008101 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 675635008102 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 675635008103 Na binding site [ion binding]; other site 675635008104 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 675635008105 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635008106 active site 675635008107 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635008108 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635008109 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635008110 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635008111 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635008112 Protein of unknown function (DUF917); Region: DUF917; pfam06032 675635008113 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 675635008114 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635008115 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 675635008116 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 675635008117 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 675635008118 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 675635008119 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635008120 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 675635008121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 675635008122 DNA binding site [nucleotide binding] 675635008123 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635008124 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 675635008125 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 675635008126 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 675635008127 active site 675635008128 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 675635008129 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 675635008130 metal binding site [ion binding]; metal-binding site 675635008131 substrate binding pocket [chemical binding]; other site 675635008132 Muconolactone delta-isomerase; Region: MIase; pfam02426 675635008133 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635008134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635008135 active site 675635008136 metal binding site [ion binding]; metal-binding site 675635008137 Predicted esterase [General function prediction only]; Region: COG0400 675635008138 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 675635008139 active site 675635008140 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 675635008141 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 675635008142 dimer interface [polypeptide binding]; other site 675635008143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635008144 catalytic residue [active] 675635008145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635008146 S-adenosylmethionine binding site [chemical binding]; other site 675635008147 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 675635008148 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635008149 classical (c) SDRs; Region: SDR_c; cd05233 675635008150 NAD(P) binding site [chemical binding]; other site 675635008151 active site 675635008152 Epoxide hydrolase N terminus; Region: EHN; pfam06441 675635008153 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635008154 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 675635008155 intersubunit interface [polypeptide binding]; other site 675635008156 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 675635008157 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 675635008158 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635008159 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 675635008160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635008161 Walker A/P-loop; other site 675635008162 ATP binding site [chemical binding]; other site 675635008163 Q-loop/lid; other site 675635008164 ABC transporter signature motif; other site 675635008165 Walker B; other site 675635008166 D-loop; other site 675635008167 H-loop/switch region; other site 675635008168 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 675635008169 Hemerythrin-like domain; Region: Hr-like; cd12108 675635008170 Fe binding site [ion binding]; other site 675635008171 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 675635008172 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 675635008173 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 675635008174 substrate binding site [chemical binding]; other site 675635008175 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 675635008176 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 675635008177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008178 NAD(P) binding site [chemical binding]; other site 675635008179 active site 675635008180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635008181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635008182 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 675635008183 Walker A/P-loop; other site 675635008184 ATP binding site [chemical binding]; other site 675635008185 Q-loop/lid; other site 675635008186 ABC transporter signature motif; other site 675635008187 Walker B; other site 675635008188 D-loop; other site 675635008189 H-loop/switch region; other site 675635008190 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 675635008191 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 675635008192 Walker A/P-loop; other site 675635008193 ATP binding site [chemical binding]; other site 675635008194 Q-loop/lid; other site 675635008195 ABC transporter signature motif; other site 675635008196 Walker B; other site 675635008197 D-loop; other site 675635008198 H-loop/switch region; other site 675635008199 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 675635008200 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 675635008201 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 675635008202 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 675635008203 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 675635008204 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 675635008205 heterodimer interface [polypeptide binding]; other site 675635008206 substrate interaction site [chemical binding]; other site 675635008207 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 675635008208 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 675635008209 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 675635008210 active site 675635008211 substrate binding site [chemical binding]; other site 675635008212 coenzyme B12 binding site [chemical binding]; other site 675635008213 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 675635008214 B12 binding site [chemical binding]; other site 675635008215 cobalt ligand [ion binding]; other site 675635008216 membrane ATPase/protein kinase; Provisional; Region: PRK09435 675635008217 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 675635008218 Walker A; other site 675635008219 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 675635008220 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 675635008221 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 675635008222 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 675635008223 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635008224 Cytochrome P450; Region: p450; cl12078 675635008225 Uncharacterized conserved protein [Function unknown]; Region: COG5361 675635008226 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 675635008227 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 675635008228 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635008229 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 675635008230 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 675635008231 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635008232 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 675635008233 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635008234 Protein of unknown function (DUF742); Region: DUF742; pfam05331 675635008235 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635008236 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635008237 active site 675635008238 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635008239 putative Zn2+ binding site [ion binding]; other site 675635008240 putative DNA binding site [nucleotide binding]; other site 675635008241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635008242 ATP binding site [chemical binding]; other site 675635008243 putative Mg++ binding site [ion binding]; other site 675635008244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635008245 nucleotide binding region [chemical binding]; other site 675635008246 ATP-binding site [chemical binding]; other site 675635008247 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 675635008248 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 675635008249 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 675635008250 active site 675635008251 DNA binding site [nucleotide binding] 675635008252 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 675635008253 DNA binding site [nucleotide binding] 675635008254 Histidine kinase; Region: His_kinase; pfam06580 675635008255 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 675635008256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635008257 motif II; other site 675635008258 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 675635008259 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 675635008260 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 675635008261 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 675635008262 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 675635008263 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635008264 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635008265 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635008266 DNA binding residues [nucleotide binding] 675635008267 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 675635008268 Part of AAA domain; Region: AAA_19; pfam13245 675635008269 Family description; Region: UvrD_C_2; pfam13538 675635008270 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 675635008271 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 675635008272 catalytic triad [active] 675635008273 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 675635008274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635008275 ATP binding site [chemical binding]; other site 675635008276 putative Mg++ binding site [ion binding]; other site 675635008277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635008278 nucleotide binding region [chemical binding]; other site 675635008279 ATP-binding site [chemical binding]; other site 675635008280 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 675635008281 HRDC domain; Region: HRDC; pfam00570 675635008282 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 675635008283 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 675635008284 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635008285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635008286 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635008287 Bacterial transcriptional activator domain; Region: BTAD; smart01043 675635008288 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635008289 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 675635008290 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 675635008291 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635008292 anti sigma factor interaction site; other site 675635008293 regulatory phosphorylation site [posttranslational modification]; other site 675635008294 hypothetical protein; Validated; Region: PRK07586 675635008295 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635008296 PYR/PP interface [polypeptide binding]; other site 675635008297 dimer interface [polypeptide binding]; other site 675635008298 TPP binding site [chemical binding]; other site 675635008299 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635008300 TPP-binding site [chemical binding]; other site 675635008301 OsmC-like protein; Region: OsmC; pfam02566 675635008302 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 675635008303 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 675635008304 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 675635008305 phosphopeptide binding site; other site 675635008306 Bifunctional nuclease; Region: DNase-RNase; pfam02577 675635008307 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635008308 DNA binding residues [nucleotide binding] 675635008309 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 675635008310 glycine dehydrogenase; Provisional; Region: PRK05367 675635008311 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635008312 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635008313 catalytic residue [active] 675635008314 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635008315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635008316 catalytic residue [active] 675635008317 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 675635008318 Domain of unknown function DUF21; Region: DUF21; pfam01595 675635008319 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 675635008320 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 675635008321 Domain of unknown function DUF21; Region: DUF21; pfam01595 675635008322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 675635008323 Transporter associated domain; Region: CorC_HlyC; smart01091 675635008324 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 675635008325 pantothenate kinase; Provisional; Region: PRK05439 675635008326 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 675635008327 ATP-binding site [chemical binding]; other site 675635008328 CoA-binding site [chemical binding]; other site 675635008329 Mg2+-binding site [ion binding]; other site 675635008330 MarR family; Region: MarR; pfam01047 675635008331 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635008332 Domain of unknown function (DUF427); Region: DUF427; pfam04248 675635008333 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635008334 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635008335 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635008336 active site 675635008337 ATP binding site [chemical binding]; other site 675635008338 substrate binding site [chemical binding]; other site 675635008339 activation loop (A-loop); other site 675635008340 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 675635008341 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 675635008342 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635008343 Predicted transcriptional regulators [Transcription]; Region: COG1733 675635008344 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635008345 dimerization interface [polypeptide binding]; other site 675635008346 putative DNA binding site [nucleotide binding]; other site 675635008347 putative Zn2+ binding site [ion binding]; other site 675635008348 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 675635008349 putative FMN binding site [chemical binding]; other site 675635008350 hypothetical protein; Provisional; Region: PRK08317 675635008351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635008352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635008353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635008354 active site 675635008355 phosphorylation site [posttranslational modification] 675635008356 intermolecular recognition site; other site 675635008357 dimerization interface [polypeptide binding]; other site 675635008358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635008359 DNA binding residues [nucleotide binding] 675635008360 dimerization interface [polypeptide binding]; other site 675635008361 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635008362 Histidine kinase; Region: HisKA_3; pfam07730 675635008363 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 675635008364 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635008365 Ligand Binding Site [chemical binding]; other site 675635008366 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635008367 Ligand Binding Site [chemical binding]; other site 675635008368 allophanate hydrolase; Provisional; Region: PRK08186 675635008369 Amidase; Region: Amidase; cl11426 675635008370 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 675635008371 SnoaL-like domain; Region: SnoaL_3; pfam13474 675635008372 Isochorismatase family; Region: Isochorismatase; pfam00857 675635008373 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 675635008374 catalytic triad [active] 675635008375 conserved cis-peptide bond; other site 675635008376 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635008377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635008378 DNA-binding site [nucleotide binding]; DNA binding site 675635008379 FCD domain; Region: FCD; pfam07729 675635008380 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559 675635008381 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635008382 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635008383 ligand binding site [chemical binding]; other site 675635008384 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635008385 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635008386 TM-ABC transporter signature motif; other site 675635008387 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635008388 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 675635008389 Walker A/P-loop; other site 675635008390 ATP binding site [chemical binding]; other site 675635008391 Q-loop/lid; other site 675635008392 Walker B; other site 675635008393 D-loop; other site 675635008394 H-loop/switch region; other site 675635008395 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 675635008396 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 675635008397 oxidase reductase; Provisional; Region: PTZ00273 675635008398 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 675635008399 Cupin domain; Region: Cupin_2; pfam07883 675635008400 hypothetical protein; Provisional; Region: PRK07538 675635008401 hypothetical protein; Provisional; Region: PRK07236 675635008402 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635008403 FAD binding domain; Region: FAD_binding_4; pfam01565 675635008404 Berberine and berberine like; Region: BBE; pfam08031 675635008405 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 675635008406 Ferredoxin [Energy production and conversion]; Region: COG1146 675635008407 4Fe-4S binding domain; Region: Fer4; pfam00037 675635008408 putative DNA binding site [nucleotide binding]; other site 675635008409 Predicted transcriptional regulator [Transcription]; Region: COG2345 675635008410 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 675635008411 putative Zn2+ binding site [ion binding]; other site 675635008412 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635008413 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635008414 DNA binding residues [nucleotide binding] 675635008415 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 675635008416 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 675635008417 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 675635008418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635008419 dimer interface [polypeptide binding]; other site 675635008420 conserved gate region; other site 675635008421 putative PBP binding loops; other site 675635008422 ABC-ATPase subunit interface; other site 675635008423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635008424 dimer interface [polypeptide binding]; other site 675635008425 conserved gate region; other site 675635008426 putative PBP binding loops; other site 675635008427 ABC-ATPase subunit interface; other site 675635008428 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 675635008429 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 675635008430 Walker A/P-loop; other site 675635008431 ATP binding site [chemical binding]; other site 675635008432 Q-loop/lid; other site 675635008433 ABC transporter signature motif; other site 675635008434 Walker B; other site 675635008435 D-loop; other site 675635008436 H-loop/switch region; other site 675635008437 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635008438 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635008439 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635008440 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635008441 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635008442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635008443 putative DNA binding site [nucleotide binding]; other site 675635008444 putative Zn2+ binding site [ion binding]; other site 675635008445 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635008446 lipid-transfer protein; Provisional; Region: PRK07855 675635008447 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635008448 active site 675635008449 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635008450 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635008451 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635008452 enoyl-CoA hydratase; Provisional; Region: PRK08252 675635008453 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635008454 substrate binding site [chemical binding]; other site 675635008455 oxyanion hole (OAH) forming residues; other site 675635008456 trimer interface [polypeptide binding]; other site 675635008457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008458 NAD(P) binding site [chemical binding]; other site 675635008459 active site 675635008460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635008461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635008462 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635008463 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635008464 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 675635008465 Strictosidine synthase; Region: Str_synth; pfam03088 675635008466 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635008467 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635008468 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 675635008469 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635008470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635008471 Amidohydrolase; Region: Amidohydro_2; pfam04909 675635008472 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635008473 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635008474 classical (c) SDRs; Region: SDR_c; cd05233 675635008475 NAD(P) binding site [chemical binding]; other site 675635008476 active site 675635008477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635008479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635008480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635008481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635008482 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635008483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635008484 DNA-binding site [nucleotide binding]; DNA binding site 675635008485 FCD domain; Region: FCD; pfam07729 675635008486 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635008487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635008488 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 675635008489 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635008490 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635008491 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635008492 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635008493 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 675635008494 Dehydratase family; Region: ILVD_EDD; cl00340 675635008495 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 675635008496 gating phenylalanine in ion channel; other site 675635008497 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635008498 dimerization interface [polypeptide binding]; other site 675635008499 putative DNA binding site [nucleotide binding]; other site 675635008500 putative Zn2+ binding site [ion binding]; other site 675635008501 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 675635008502 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635008503 putative ligand binding site [chemical binding]; other site 675635008504 Amidase; Region: Amidase; cl11426 675635008505 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635008506 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635008507 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 675635008508 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635008509 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635008510 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635008511 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 675635008512 Methyltransferase domain; Region: Methyltransf_31; pfam13847 675635008513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635008514 S-adenosylmethionine binding site [chemical binding]; other site 675635008515 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635008516 Amidase; Region: Amidase; cl11426 675635008517 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 675635008518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008519 Walker A motif; other site 675635008520 ATP binding site [chemical binding]; other site 675635008521 Walker B motif; other site 675635008522 arginine finger; other site 675635008523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635008524 Integrase core domain; Region: rve; pfam00665 675635008525 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 675635008526 hypothetical protein; Provisional; Region: PRK07236 675635008527 Predicted transcriptional regulators [Transcription]; Region: COG1695 675635008528 Transcriptional regulator PadR-like family; Region: PadR; cl17335 675635008529 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635008530 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635008531 MarR family; Region: MarR_2; pfam12802 675635008532 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 675635008533 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 675635008534 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 675635008535 Uncharacterized conserved protein [Function unknown]; Region: COG3189 675635008536 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635008537 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 675635008538 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635008539 Cytochrome P450; Region: p450; cl12078 675635008540 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 675635008541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635008542 Walker A/P-loop; other site 675635008543 ATP binding site [chemical binding]; other site 675635008544 Q-loop/lid; other site 675635008545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635008546 ABC transporter signature motif; other site 675635008547 Walker B; other site 675635008548 D-loop; other site 675635008549 H-loop/switch region; other site 675635008550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635008551 Walker A/P-loop; other site 675635008552 ATP binding site [chemical binding]; other site 675635008553 Q-loop/lid; other site 675635008554 ABC transporter signature motif; other site 675635008555 Walker B; other site 675635008556 D-loop; other site 675635008557 H-loop/switch region; other site 675635008558 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635008559 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635008560 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635008561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635008562 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 675635008563 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 675635008564 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 675635008565 heme binding site [chemical binding]; other site 675635008566 ferroxidase pore; other site 675635008567 ferroxidase diiron center [ion binding]; other site 675635008568 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 675635008569 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 675635008570 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 675635008571 active site 675635008572 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 675635008573 nucleotide binding site [chemical binding]; other site 675635008574 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 675635008575 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 675635008576 active site 675635008577 catalytic site [active] 675635008578 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 675635008579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008580 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 675635008581 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635008582 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 675635008583 Ligand binding site; other site 675635008584 Putative Catalytic site; other site 675635008585 DXD motif; other site 675635008586 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 675635008587 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 675635008588 putative active site [active] 675635008589 catalytic triad [active] 675635008590 putative dimer interface [polypeptide binding]; other site 675635008591 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635008592 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635008593 Amidohydrolase family; Region: Amidohydro_3; pfam07969 675635008594 active site 675635008595 PspC domain; Region: PspC; pfam04024 675635008596 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635008597 oxyanion hole [active] 675635008598 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 675635008599 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 675635008600 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 675635008601 active site 675635008602 5'-3' exonuclease; Region: 53EXOc; smart00475 675635008603 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 675635008604 active site 675635008605 metal binding site 1 [ion binding]; metal-binding site 675635008606 putative 5' ssDNA interaction site; other site 675635008607 metal binding site 3; metal-binding site 675635008608 metal binding site 2 [ion binding]; metal-binding site 675635008609 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 675635008610 putative DNA binding site [nucleotide binding]; other site 675635008611 putative metal binding site [ion binding]; other site 675635008612 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 675635008613 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 675635008614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635008615 ATP binding site [chemical binding]; other site 675635008616 putative Mg++ binding site [ion binding]; other site 675635008617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635008618 nucleotide binding region [chemical binding]; other site 675635008619 ATP-binding site [chemical binding]; other site 675635008620 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 675635008621 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 675635008622 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 675635008623 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 675635008624 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635008625 WYL domain; Region: WYL; pfam13280 675635008626 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635008627 WYL domain; Region: WYL; pfam13280 675635008628 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 675635008629 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 675635008630 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 675635008631 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635008632 catalytic loop [active] 675635008633 iron binding site [ion binding]; other site 675635008634 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 675635008635 Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; pfam04879 675635008636 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 675635008637 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 675635008638 putative dimer interface [polypeptide binding]; other site 675635008639 [2Fe-2S] cluster binding site [ion binding]; other site 675635008640 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 675635008641 SLBB domain; Region: SLBB; pfam10531 675635008642 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 675635008643 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 675635008644 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635008645 molybdopterin cofactor binding site; other site 675635008646 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 675635008647 molybdopterin cofactor binding site; other site 675635008648 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635008649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635008650 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 675635008651 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635008652 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635008653 active site 675635008654 metal binding site [ion binding]; metal-binding site 675635008655 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635008656 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635008657 active site 675635008658 metal binding site [ion binding]; metal-binding site 675635008659 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 675635008660 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 675635008661 active site 675635008662 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 675635008663 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 675635008664 active site 675635008665 Pup-like protein; Region: Pup; pfam05639 675635008666 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 675635008667 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 675635008668 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635008669 nudix motif; other site 675635008670 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 675635008671 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635008672 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635008673 MarR family; Region: MarR_2; pfam12802 675635008674 Uncharacterized conserved protein [Function unknown]; Region: COG2353 675635008675 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 675635008676 classical (c) SDRs; Region: SDR_c; cd05233 675635008677 NAD(P) binding site [chemical binding]; other site 675635008678 active site 675635008679 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635008680 MarR family; Region: MarR_2; pfam12802 675635008681 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635008682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635008683 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635008684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635008685 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 675635008686 dimer interface [polypeptide binding]; other site 675635008687 ligand binding site [chemical binding]; other site 675635008688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008689 Walker A motif; other site 675635008690 ATP binding site [chemical binding]; other site 675635008691 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635008692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635008693 DNA binding residues [nucleotide binding] 675635008694 dimerization interface [polypeptide binding]; other site 675635008695 YceI-like domain; Region: YceI; pfam04264 675635008696 proteasome ATPase; Region: pup_AAA; TIGR03689 675635008697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008698 Walker A motif; other site 675635008699 ATP binding site [chemical binding]; other site 675635008700 Walker B motif; other site 675635008701 arginine finger; other site 675635008702 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 675635008703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635008704 S-adenosylmethionine binding site [chemical binding]; other site 675635008705 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 675635008706 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 675635008707 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 675635008708 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 675635008709 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 675635008710 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 675635008711 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 675635008712 homodimer interface [polypeptide binding]; other site 675635008713 putative metal binding site [ion binding]; other site 675635008714 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 675635008715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 675635008716 motif I; other site 675635008717 active site 675635008718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635008719 motif II; other site 675635008720 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 675635008721 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 675635008722 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 675635008723 substrate binding pocket [chemical binding]; other site 675635008724 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 675635008725 B12 binding site [chemical binding]; other site 675635008726 cobalt ligand [ion binding]; other site 675635008727 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 675635008728 PAC2 family; Region: PAC2; pfam09754 675635008729 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635008730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008731 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 675635008732 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635008733 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 675635008734 active site 675635008735 HIGH motif; other site 675635008736 nucleotide binding site [chemical binding]; other site 675635008737 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635008738 active site 675635008739 KMSKS motif; other site 675635008740 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 675635008741 putative tRNA binding surface [nucleotide binding]; other site 675635008742 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 675635008743 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 675635008744 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 675635008745 metal ion-dependent adhesion site (MIDAS); other site 675635008746 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 675635008747 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 675635008748 Protein of unknown function (DUF664); Region: DUF664; pfam04978 675635008749 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 675635008750 Penicillinase repressor; Region: Pencillinase_R; pfam03965 675635008751 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 675635008752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008753 putative substrate translocation pore; other site 675635008754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008755 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 675635008756 Uncharacterized conserved protein [Function unknown]; Region: COG3349 675635008757 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 675635008758 active site 675635008759 DNA binding site [nucleotide binding] 675635008760 catalytic site [active] 675635008761 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 675635008762 active site 675635008763 catalytic triad [active] 675635008764 oxyanion hole [active] 675635008765 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 675635008766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635008767 S-adenosylmethionine binding site [chemical binding]; other site 675635008768 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 675635008769 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 675635008770 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635008771 catalytic residue [active] 675635008772 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 675635008773 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635008774 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635008775 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635008776 active site 675635008777 succinic semialdehyde dehydrogenase; Region: PLN02278 675635008778 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 675635008779 tetramerization interface [polypeptide binding]; other site 675635008780 NAD(P) binding site [chemical binding]; other site 675635008781 catalytic residues [active] 675635008782 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 675635008783 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 675635008784 PDGLE domain; Region: PDGLE; cl07986 675635008785 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 675635008786 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635008787 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 675635008788 Walker A/P-loop; other site 675635008789 ATP binding site [chemical binding]; other site 675635008790 Q-loop/lid; other site 675635008791 ABC transporter signature motif; other site 675635008792 Walker B; other site 675635008793 D-loop; other site 675635008794 H-loop/switch region; other site 675635008795 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 675635008796 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 675635008797 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 675635008798 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 675635008799 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635008800 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 675635008801 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635008802 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635008803 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635008804 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635008805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008806 NAD(P) binding site [chemical binding]; other site 675635008807 active site 675635008808 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635008809 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635008810 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 675635008811 dimer interface [polypeptide binding]; other site 675635008812 acyl-activating enzyme (AAE) consensus motif; other site 675635008813 putative active site [active] 675635008814 AMP binding site [chemical binding]; other site 675635008815 putative CoA binding site [chemical binding]; other site 675635008816 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635008817 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635008818 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 675635008819 putative active site [active] 675635008820 putative substrate binding site [chemical binding]; other site 675635008821 ATP binding site [chemical binding]; other site 675635008822 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635008823 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635008824 active site 675635008825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635008826 active site 675635008827 DNA binding site [nucleotide binding] 675635008828 Int/Topo IB signature motif; other site 675635008829 ferrochelatase; Reviewed; Region: hemH; PRK00035 675635008830 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 675635008831 C-terminal domain interface [polypeptide binding]; other site 675635008832 active site 675635008833 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 675635008834 active site 675635008835 N-terminal domain interface [polypeptide binding]; other site 675635008836 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 675635008837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008838 NAD(P) binding site [chemical binding]; other site 675635008839 active site 675635008840 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 675635008841 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 675635008842 NAD(P) binding site [chemical binding]; other site 675635008843 homotetramer interface [polypeptide binding]; other site 675635008844 homodimer interface [polypeptide binding]; other site 675635008845 active site 675635008846 hypothetical protein; Provisional; Region: PRK13685 675635008847 von Willebrand factor type A domain; Region: VWA_2; pfam13519 675635008848 metal ion-dependent adhesion site (MIDAS); other site 675635008849 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 675635008850 Protein of unknown function DUF58; Region: DUF58; pfam01882 675635008851 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635008852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635008853 Walker A motif; other site 675635008854 ATP binding site [chemical binding]; other site 675635008855 Walker B motif; other site 675635008856 arginine finger; other site 675635008857 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635008858 NlpC/P60 family; Region: NLPC_P60; pfam00877 675635008859 aconitate hydratase; Validated; Region: PRK09277 675635008860 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 675635008861 substrate binding site [chemical binding]; other site 675635008862 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 675635008863 ligand binding site [chemical binding]; other site 675635008864 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 675635008865 substrate binding site [chemical binding]; other site 675635008866 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 675635008867 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 675635008868 Cupin domain; Region: Cupin_2; cl17218 675635008869 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 675635008870 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 675635008871 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 675635008872 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 675635008873 putative active site [active] 675635008874 putative dimer interface [polypeptide binding]; other site 675635008875 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 675635008876 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 675635008877 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 675635008878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635008879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635008880 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635008881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635008882 putative substrate translocation pore; other site 675635008883 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635008884 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635008885 substrate binding site [chemical binding]; other site 675635008886 oxyanion hole (OAH) forming residues; other site 675635008887 trimer interface [polypeptide binding]; other site 675635008888 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 675635008889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 675635008890 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 675635008891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 675635008892 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 675635008893 classical (c) SDRs; Region: SDR_c; cd05233 675635008894 NAD(P) binding site [chemical binding]; other site 675635008895 active site 675635008896 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635008897 Ligand Binding Site [chemical binding]; other site 675635008898 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 675635008899 cyclase homology domain; Region: CHD; cd07302 675635008900 nucleotidyl binding site; other site 675635008901 metal binding site [ion binding]; metal-binding site 675635008902 dimer interface [polypeptide binding]; other site 675635008903 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 675635008904 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 675635008905 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 675635008906 trimerization site [polypeptide binding]; other site 675635008907 active site 675635008908 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 675635008909 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 675635008910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635008911 catalytic residue [active] 675635008912 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 675635008913 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 675635008914 Walker A/P-loop; other site 675635008915 ATP binding site [chemical binding]; other site 675635008916 Q-loop/lid; other site 675635008917 ABC transporter signature motif; other site 675635008918 Walker B; other site 675635008919 D-loop; other site 675635008920 H-loop/switch region; other site 675635008921 FeS assembly protein SufD; Region: sufD; TIGR01981 675635008922 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 675635008923 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 675635008924 FeS assembly protein SufB; Region: sufB; TIGR01980 675635008925 Predicted transcriptional regulator [Transcription]; Region: COG2345 675635008926 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 675635008927 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635008928 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 675635008929 Walker A/P-loop; other site 675635008930 ATP binding site [chemical binding]; other site 675635008931 Q-loop/lid; other site 675635008932 ABC transporter signature motif; other site 675635008933 Walker B; other site 675635008934 D-loop; other site 675635008935 H-loop/switch region; other site 675635008936 ABC-2 type transporter; Region: ABC2_membrane; cl17235 675635008937 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 675635008938 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 675635008939 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 675635008940 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 675635008941 NADP binding site [chemical binding]; other site 675635008942 dimer interface [polypeptide binding]; other site 675635008943 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 675635008944 UbiA prenyltransferase family; Region: UbiA; pfam01040 675635008945 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 675635008946 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 675635008947 TPP-binding site [chemical binding]; other site 675635008948 dimer interface [polypeptide binding]; other site 675635008949 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 675635008950 PYR/PP interface [polypeptide binding]; other site 675635008951 dimer interface [polypeptide binding]; other site 675635008952 TPP binding site [chemical binding]; other site 675635008953 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635008954 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 675635008955 putative active site [active] 675635008956 transaldolase; Provisional; Region: PRK03903 675635008957 catalytic residue [active] 675635008958 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 675635008959 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 675635008960 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 675635008961 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 675635008962 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 675635008963 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 675635008964 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 675635008965 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 675635008966 putative active site [active] 675635008967 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 675635008968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635008969 ATP-grasp domain; Region: ATP-grasp; pfam02222 675635008970 Methyltransferase domain; Region: Methyltransf_24; pfam13578 675635008971 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 675635008972 triosephosphate isomerase; Provisional; Region: PRK14567 675635008973 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 675635008974 substrate binding site [chemical binding]; other site 675635008975 dimer interface [polypeptide binding]; other site 675635008976 catalytic triad [active] 675635008977 Phosphoglycerate kinase; Region: PGK; pfam00162 675635008978 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 675635008979 substrate binding site [chemical binding]; other site 675635008980 hinge regions; other site 675635008981 ADP binding site [chemical binding]; other site 675635008982 catalytic site [active] 675635008983 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 675635008984 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 675635008985 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 675635008986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 675635008987 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 675635008988 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 675635008989 putative substrate binding pocket [chemical binding]; other site 675635008990 dimer interface [polypeptide binding]; other site 675635008991 phosphate binding site [ion binding]; other site 675635008992 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 675635008993 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 675635008994 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 675635008995 GIY-YIG motif/motif A; other site 675635008996 active site 675635008997 catalytic site [active] 675635008998 putative DNA binding site [nucleotide binding]; other site 675635008999 metal binding site [ion binding]; metal-binding site 675635009000 UvrB/uvrC motif; Region: UVR; pfam02151 675635009001 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 675635009002 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 675635009003 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 675635009004 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 675635009005 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 675635009006 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 675635009007 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 675635009008 homopentamer interface [polypeptide binding]; other site 675635009009 active site 675635009010 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 675635009011 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 675635009012 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 675635009013 dimerization interface [polypeptide binding]; other site 675635009014 active site 675635009015 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 675635009016 Lumazine binding domain; Region: Lum_binding; pfam00677 675635009017 Lumazine binding domain; Region: Lum_binding; pfam00677 675635009018 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 675635009019 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 675635009020 active site 675635009021 Zn binding site [ion binding]; other site 675635009022 RibD C-terminal domain; Region: RibD_C; pfam01872 675635009023 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 675635009024 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 675635009025 substrate binding site [chemical binding]; other site 675635009026 hexamer interface [polypeptide binding]; other site 675635009027 metal binding site [ion binding]; metal-binding site 675635009028 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 675635009029 putative RNA binding site [nucleotide binding]; other site 675635009030 16S rRNA methyltransferase B; Provisional; Region: PRK14902 675635009031 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 675635009032 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 675635009033 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 675635009034 putative active site [active] 675635009035 substrate binding site [chemical binding]; other site 675635009036 putative cosubstrate binding site; other site 675635009037 catalytic site [active] 675635009038 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 675635009039 substrate binding site [chemical binding]; other site 675635009040 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 675635009041 active site 675635009042 catalytic residues [active] 675635009043 metal binding site [ion binding]; metal-binding site 675635009044 primosome assembly protein PriA; Provisional; Region: PRK14873 675635009045 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 675635009046 Cupin domain; Region: Cupin_2; pfam07883 675635009047 S-adenosylmethionine synthetase; Validated; Region: PRK05250 675635009048 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 675635009049 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 675635009050 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 675635009051 Bacterial SH3 domain; Region: SH3_3; cl17532 675635009052 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 675635009053 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 675635009054 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 675635009055 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635009056 Ferritin-like domain; Region: Ferritin; pfam00210 675635009057 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 675635009058 dimerization interface [polypeptide binding]; other site 675635009059 DPS ferroxidase diiron center [ion binding]; other site 675635009060 ion pore; other site 675635009061 Protease prsW family; Region: PrsW-protease; pfam13367 675635009062 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 675635009063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635009064 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 675635009065 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 675635009066 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 675635009067 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 675635009068 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635009069 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635009070 ligand binding site [chemical binding]; other site 675635009071 flexible hinge region; other site 675635009072 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 675635009073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635009074 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 675635009075 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 675635009076 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 675635009077 NAD binding site [chemical binding]; other site 675635009078 catalytic Zn binding site [ion binding]; other site 675635009079 structural Zn binding site [ion binding]; other site 675635009080 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 675635009081 BON domain; Region: BON; pfam04972 675635009082 BON domain; Region: BON; cl02771 675635009083 transketolase; Reviewed; Region: PRK05899 675635009084 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 675635009085 TPP-binding site [chemical binding]; other site 675635009086 dimer interface [polypeptide binding]; other site 675635009087 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 675635009088 PYR/PP interface [polypeptide binding]; other site 675635009089 dimer interface [polypeptide binding]; other site 675635009090 TPP binding site [chemical binding]; other site 675635009091 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635009092 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 675635009093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635009094 Walker A motif; other site 675635009095 ATP binding site [chemical binding]; other site 675635009096 Walker B motif; other site 675635009097 arginine finger; other site 675635009098 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 675635009099 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635009100 active site 675635009101 DNA binding site [nucleotide binding] 675635009102 Int/Topo IB signature motif; other site 675635009103 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 675635009104 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635009105 active site 675635009106 catalytic residues [active] 675635009107 DNA binding site [nucleotide binding] 675635009108 Int/Topo IB signature motif; other site 675635009109 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 675635009110 Mechanosensitive ion channel; Region: MS_channel; pfam00924 675635009111 Protein of unknown function (DUF461); Region: DUF461; cl01071 675635009112 pyruvate dehydrogenase; Provisional; Region: PRK09124 675635009113 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 675635009114 PYR/PP interface [polypeptide binding]; other site 675635009115 tetramer interface [polypeptide binding]; other site 675635009116 dimer interface [polypeptide binding]; other site 675635009117 TPP binding site [chemical binding]; other site 675635009118 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 675635009119 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 675635009120 TPP-binding site [chemical binding]; other site 675635009121 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635009122 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635009123 active site 675635009124 Erythromycin esterase; Region: Erythro_esteras; pfam05139 675635009125 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 675635009126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635009127 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 675635009128 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635009129 DNA binding residues [nucleotide binding] 675635009130 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635009131 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 675635009132 catalytic residues [active] 675635009133 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 675635009134 Clp amino terminal domain; Region: Clp_N; pfam02861 675635009135 Clp amino terminal domain; Region: Clp_N; pfam02861 675635009136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635009137 Walker A motif; other site 675635009138 ATP binding site [chemical binding]; other site 675635009139 Walker B motif; other site 675635009140 arginine finger; other site 675635009141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635009142 Walker A motif; other site 675635009143 ATP binding site [chemical binding]; other site 675635009144 Walker B motif; other site 675635009145 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 675635009146 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 675635009147 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635009148 DNA binding residues [nucleotide binding] 675635009149 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 675635009150 HSP70 interaction site [polypeptide binding]; other site 675635009151 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 675635009152 substrate binding site [polypeptide binding]; other site 675635009153 dimer interface [polypeptide binding]; other site 675635009154 heat shock protein GrpE; Provisional; Region: PRK14140 675635009155 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 675635009156 dimer interface [polypeptide binding]; other site 675635009157 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 675635009158 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 675635009159 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 675635009160 nucleotide binding site [chemical binding]; other site 675635009161 NEF interaction site [polypeptide binding]; other site 675635009162 SBD interface [polypeptide binding]; other site 675635009163 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 675635009164 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 675635009165 putative dimer interface [polypeptide binding]; other site 675635009166 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635009167 anti sigma factor interaction site; other site 675635009168 regulatory phosphorylation site [posttranslational modification]; other site 675635009169 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 675635009170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009171 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 675635009172 Transcription factor WhiB; Region: Whib; pfam02467 675635009173 ParB-like nuclease domain; Region: ParBc; pfam02195 675635009174 BON domain; Region: BON; pfam04972 675635009175 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 675635009176 BON domain; Region: BON; pfam04972 675635009177 BON domain; Region: BON; pfam04972 675635009178 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 675635009179 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 675635009180 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 675635009181 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 675635009182 Protein required for attachment to host cells; Region: Host_attach; cl02398 675635009183 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635009184 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635009185 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 675635009186 intracellular protease, PfpI family; Region: PfpI; TIGR01382 675635009187 proposed catalytic triad [active] 675635009188 conserved cys residue [active] 675635009189 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 675635009190 Helix-turn-helix domain; Region: HTH_28; pfam13518 675635009191 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635009192 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 675635009193 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635009194 putative ADP-binding pocket [chemical binding]; other site 675635009195 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 675635009196 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 675635009197 Flavoprotein; Region: Flavoprotein; pfam02441 675635009198 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 675635009199 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 675635009200 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 675635009201 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 675635009202 catalytic site [active] 675635009203 G-X2-G-X-G-K; other site 675635009204 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635009205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635009206 active site 675635009207 phosphorylation site [posttranslational modification] 675635009208 intermolecular recognition site; other site 675635009209 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 675635009210 active site 675635009211 dimer interface [polypeptide binding]; other site 675635009212 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 675635009213 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635009214 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635009215 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 675635009216 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635009217 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635009218 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 675635009219 IMP binding site; other site 675635009220 dimer interface [polypeptide binding]; other site 675635009221 interdomain contacts; other site 675635009222 partial ornithine binding site; other site 675635009223 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 675635009224 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 675635009225 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 675635009226 catalytic site [active] 675635009227 subunit interface [polypeptide binding]; other site 675635009228 dihydroorotase; Validated; Region: pyrC; PRK09357 675635009229 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635009230 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 675635009231 active site 675635009232 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 675635009233 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 675635009234 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 675635009235 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 675635009236 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 675635009237 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 675635009238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635009239 non-specific DNA binding site [nucleotide binding]; other site 675635009240 salt bridge; other site 675635009241 sequence-specific DNA binding site [nucleotide binding]; other site 675635009242 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 675635009243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009244 putative substrate translocation pore; other site 675635009245 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 675635009246 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 675635009247 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 675635009248 transcription antitermination factor NusB; Region: nusB; TIGR01951 675635009249 putative RNA binding site [nucleotide binding]; other site 675635009250 elongation factor P; Validated; Region: PRK00529 675635009251 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 675635009252 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 675635009253 RNA binding site [nucleotide binding]; other site 675635009254 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 675635009255 RNA binding site [nucleotide binding]; other site 675635009256 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 675635009257 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 675635009258 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 675635009259 active site 675635009260 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 675635009261 active site 675635009262 dimer interface [polypeptide binding]; other site 675635009263 metal binding site [ion binding]; metal-binding site 675635009264 shikimate kinase; Reviewed; Region: aroK; PRK00131 675635009265 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 675635009266 ADP binding site [chemical binding]; other site 675635009267 magnesium binding site [ion binding]; other site 675635009268 putative shikimate binding site; other site 675635009269 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 675635009270 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 675635009271 Tetramer interface [polypeptide binding]; other site 675635009272 active site 675635009273 FMN-binding site [chemical binding]; other site 675635009274 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 675635009275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635009276 YceG-like family; Region: YceG; pfam02618 675635009277 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 675635009278 dimerization interface [polypeptide binding]; other site 675635009279 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 675635009280 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 675635009281 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 675635009282 motif 1; other site 675635009283 active site 675635009284 motif 2; other site 675635009285 motif 3; other site 675635009286 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 675635009287 DHHA1 domain; Region: DHHA1; pfam02272 675635009288 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635009289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635009290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635009291 DNA binding residues [nucleotide binding] 675635009292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635009293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635009294 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635009295 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 675635009296 inhibitor-cofactor binding pocket; inhibition site 675635009297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635009298 catalytic residue [active] 675635009299 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 675635009300 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 675635009301 Amidinotransferase; Region: Amidinotransf; cl12043 675635009302 hypothetical protein; Provisional; Region: PRK07588 675635009303 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635009304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635009305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635009306 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635009307 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635009308 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635009309 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635009310 Amidase; Region: Amidase; pfam01425 675635009311 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635009312 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635009313 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635009314 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635009315 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 675635009316 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 675635009317 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 675635009318 active site 675635009319 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635009320 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 675635009321 recombination factor protein RarA; Reviewed; Region: PRK13342 675635009322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635009323 Walker A motif; other site 675635009324 ATP binding site [chemical binding]; other site 675635009325 Walker B motif; other site 675635009326 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 675635009327 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 675635009328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635009329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635009330 homodimer interface [polypeptide binding]; other site 675635009331 catalytic residue [active] 675635009332 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635009333 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 675635009334 AsnC family; Region: AsnC_trans_reg; pfam01037 675635009335 hypothetical protein; Validated; Region: PRK07682 675635009336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635009337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635009338 homodimer interface [polypeptide binding]; other site 675635009339 catalytic residue [active] 675635009340 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635009341 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635009342 active site 675635009343 oxyanion hole [active] 675635009344 catalytic triad [active] 675635009345 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 675635009346 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 675635009347 dimer interface [polypeptide binding]; other site 675635009348 anticodon binding site; other site 675635009349 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 675635009350 homodimer interface [polypeptide binding]; other site 675635009351 motif 1; other site 675635009352 active site 675635009353 motif 2; other site 675635009354 GAD domain; Region: GAD; pfam02938 675635009355 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 675635009356 active site 675635009357 motif 3; other site 675635009358 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 675635009359 protein-splicing catalytic site; other site 675635009360 thioester formation/cholesterol transfer; other site 675635009361 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942 675635009362 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 675635009363 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 675635009364 YibE/F-like protein; Region: YibE_F; pfam07907 675635009365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635009366 S-adenosylmethionine binding site [chemical binding]; other site 675635009367 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 675635009368 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 675635009369 motif 1; other site 675635009370 dimer interface [polypeptide binding]; other site 675635009371 active site 675635009372 motif 2; other site 675635009373 motif 3; other site 675635009374 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 675635009375 anticodon binding site; other site 675635009376 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 675635009377 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 675635009378 active site 675635009379 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 675635009380 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635009381 Zn2+ binding site [ion binding]; other site 675635009382 Mg2+ binding site [ion binding]; other site 675635009383 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 675635009384 synthetase active site [active] 675635009385 NTP binding site [chemical binding]; other site 675635009386 metal binding site [ion binding]; metal-binding site 675635009387 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 675635009388 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 675635009389 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635009390 active site 675635009391 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 675635009392 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 675635009393 Protein export membrane protein; Region: SecD_SecF; cl14618 675635009394 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 675635009395 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 675635009396 Preprotein translocase subunit; Region: YajC; cl00806 675635009397 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 675635009398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635009399 Walker A motif; other site 675635009400 ATP binding site [chemical binding]; other site 675635009401 Walker B motif; other site 675635009402 arginine finger; other site 675635009403 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 675635009404 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 675635009405 RuvA N terminal domain; Region: RuvA_N; pfam01330 675635009406 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 675635009407 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 675635009408 active site 675635009409 putative DNA-binding cleft [nucleotide binding]; other site 675635009410 dimer interface [polypeptide binding]; other site 675635009411 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635009412 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635009413 active site 675635009414 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 675635009415 5'-3' exonuclease; Region: 53EXOc; smart00475 675635009416 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 675635009417 active site 675635009418 metal binding site 1 [ion binding]; metal-binding site 675635009419 putative 5' ssDNA interaction site; other site 675635009420 metal binding site 3; metal-binding site 675635009421 metal binding site 2 [ion binding]; metal-binding site 675635009422 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 675635009423 putative DNA binding site [nucleotide binding]; other site 675635009424 putative metal binding site [ion binding]; other site 675635009425 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 675635009426 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 675635009427 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 675635009428 active site 675635009429 DNA binding site [nucleotide binding] 675635009430 catalytic site [active] 675635009431 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 675635009432 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 675635009433 putative metal binding site [ion binding]; other site 675635009434 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 675635009435 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 675635009436 putative metal binding site [ion binding]; other site 675635009437 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 675635009438 tellurite resistance protein terB; Region: terB; cd07176 675635009439 putative metal binding site [ion binding]; other site 675635009440 hypothetical protein; Provisional; Region: PRK14013 675635009441 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 675635009442 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 675635009443 putative metal binding site [ion binding]; other site 675635009444 hypothetical protein; Validated; Region: PRK00110 675635009445 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 675635009446 predicted active site [active] 675635009447 catalytic triad [active] 675635009448 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 675635009449 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 675635009450 Malic enzyme, N-terminal domain; Region: malic; pfam00390 675635009451 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 675635009452 putative NAD(P) binding site [chemical binding]; other site 675635009453 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 675635009454 elongation factor G; Reviewed; Region: PRK12740 675635009455 G1 box; other site 675635009456 putative GEF interaction site [polypeptide binding]; other site 675635009457 GTP/Mg2+ binding site [chemical binding]; other site 675635009458 Switch I region; other site 675635009459 G2 box; other site 675635009460 G3 box; other site 675635009461 Switch II region; other site 675635009462 G4 box; other site 675635009463 G5 box; other site 675635009464 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 675635009465 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 675635009466 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 675635009467 AzlC protein; Region: AzlC; pfam03591 675635009468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 675635009469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635009470 non-specific DNA binding site [nucleotide binding]; other site 675635009471 salt bridge; other site 675635009472 sequence-specific DNA binding site [nucleotide binding]; other site 675635009473 Cupin domain; Region: Cupin_2; pfam07883 675635009474 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 675635009475 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 675635009476 iron-sulfur cluster [ion binding]; other site 675635009477 [2Fe-2S] cluster binding site [ion binding]; other site 675635009478 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 675635009479 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 675635009480 active site 675635009481 multimer interface [polypeptide binding]; other site 675635009482 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635009483 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 675635009484 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 675635009485 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 675635009486 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 675635009487 putative acyl-acceptor binding pocket; other site 675635009488 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 675635009489 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 675635009490 nucleotide binding site/active site [active] 675635009491 HIT family signature motif; other site 675635009492 catalytic residue [active] 675635009493 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 675635009494 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 675635009495 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 675635009496 active site 675635009497 dimer interface [polypeptide binding]; other site 675635009498 motif 1; other site 675635009499 motif 2; other site 675635009500 motif 3; other site 675635009501 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 675635009502 anticodon binding site; other site 675635009503 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 675635009504 Transglycosylase; Region: Transgly; pfam00912 675635009505 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 675635009506 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 675635009507 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 675635009508 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635009509 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 675635009510 DNA binding residues [nucleotide binding] 675635009511 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 675635009512 PAS fold; Region: PAS; pfam00989 675635009513 PAS fold; Region: PAS_4; pfam08448 675635009514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635009515 putative active site [active] 675635009516 heme pocket [chemical binding]; other site 675635009517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635009518 putative active site [active] 675635009519 PAS fold; Region: PAS_3; pfam08447 675635009520 heme pocket [chemical binding]; other site 675635009521 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635009522 GAF domain; Region: GAF; pfam01590 675635009523 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 675635009524 Protein of unknown function (DUF419); Region: DUF419; pfam04237 675635009525 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635009526 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635009527 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 675635009528 Pirin-related protein [General function prediction only]; Region: COG1741 675635009529 Pirin; Region: Pirin; pfam02678 675635009530 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 675635009531 Predicted acetyltransferase [General function prediction only]; Region: COG2388 675635009532 SNF2 Helicase protein; Region: DUF3670; pfam12419 675635009533 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 675635009534 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635009535 ATP binding site [chemical binding]; other site 675635009536 putative Mg++ binding site [ion binding]; other site 675635009537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635009538 nucleotide binding region [chemical binding]; other site 675635009539 ATP-binding site [chemical binding]; other site 675635009540 Uncharacterized conserved protein [Function unknown]; Region: COG4279 675635009541 SWIM zinc finger; Region: SWIM; pfam04434 675635009542 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 675635009543 integral membrane protein; Region: integ_memb_HG; TIGR03954 675635009544 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 675635009545 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635009546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635009547 catalytic residue [active] 675635009548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 675635009549 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 675635009550 GTP cyclohydrolase I; Provisional; Region: PLN03044 675635009551 active site 675635009552 Helix-turn-helix domain; Region: HTH_20; pfam12840 675635009553 putative DNA binding site [nucleotide binding]; other site 675635009554 dimerization interface [polypeptide binding]; other site 675635009555 Predicted transcriptional regulator [Transcription]; Region: COG2345 675635009556 putative Zn2+ binding site [ion binding]; other site 675635009557 Transglycosylase; Region: Transgly; pfam00912 675635009558 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 675635009559 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 675635009560 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 675635009561 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 675635009562 short chain dehydrogenase; Provisional; Region: PRK08251 675635009563 classical (c) SDRs; Region: SDR_c; cd05233 675635009564 NAD(P) binding site [chemical binding]; other site 675635009565 active site 675635009566 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 675635009567 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 675635009568 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 675635009569 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 675635009570 shikimate binding site; other site 675635009571 NAD(P) binding site [chemical binding]; other site 675635009572 hypothetical protein; Provisional; Region: PRK08317 675635009573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635009574 S-adenosylmethionine binding site [chemical binding]; other site 675635009575 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635009576 MarR family; Region: MarR_2; pfam12802 675635009577 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 675635009578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635009579 Walker A/P-loop; other site 675635009580 ATP binding site [chemical binding]; other site 675635009581 Q-loop/lid; other site 675635009582 ABC transporter signature motif; other site 675635009583 Walker B; other site 675635009584 D-loop; other site 675635009585 H-loop/switch region; other site 675635009586 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 675635009587 ABC-2 type transporter; Region: ABC2_membrane; cl17235 675635009588 phosphoglucomutase; Validated; Region: PRK07564 675635009589 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 675635009590 active site 675635009591 substrate binding site [chemical binding]; other site 675635009592 metal binding site [ion binding]; metal-binding site 675635009593 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 675635009594 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 675635009595 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635009596 anti sigma factor interaction site; other site 675635009597 regulatory phosphorylation site [posttranslational modification]; other site 675635009598 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635009599 anti sigma factor interaction site; other site 675635009600 regulatory phosphorylation site [posttranslational modification]; other site 675635009601 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635009602 hypothetical protein; Provisional; Region: PRK06834 675635009603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635009604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635009605 DinB superfamily; Region: DinB_2; pfam12867 675635009606 Protein of unknown function (DUF664); Region: DUF664; pfam04978 675635009607 RNA polymerase factor sigma-70; Validated; Region: PRK08241 675635009608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635009609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635009610 DNA binding residues [nucleotide binding] 675635009611 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635009612 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 675635009613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635009614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635009615 non-specific DNA binding site [nucleotide binding]; other site 675635009616 salt bridge; other site 675635009617 sequence-specific DNA binding site [nucleotide binding]; other site 675635009618 Domain of unknown function (DUF397); Region: DUF397; pfam04149 675635009619 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635009620 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635009621 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 675635009622 galactokinase; Provisional; Region: PRK00555 675635009623 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 675635009624 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 675635009625 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 675635009626 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 675635009627 nucleotide binding site/active site [active] 675635009628 HIT family signature motif; other site 675635009629 catalytic residue [active] 675635009630 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 675635009631 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 675635009632 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 675635009633 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 675635009634 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 675635009635 Na binding site [ion binding]; other site 675635009636 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 675635009637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635009638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635009639 active site 675635009640 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635009641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635009642 DNA-binding site [nucleotide binding]; DNA binding site 675635009643 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 675635009644 nucleotide binding site [chemical binding]; other site 675635009645 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 675635009646 intersubunit interface [polypeptide binding]; other site 675635009647 active site 675635009648 Zn2+ binding site [ion binding]; other site 675635009649 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635009650 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 675635009651 substrate binding pocket [chemical binding]; other site 675635009652 aspartate-rich region 2; other site 675635009653 substrate-Mg2+ binding site; other site 675635009654 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 675635009655 active site lid residues [active] 675635009656 substrate binding pocket [chemical binding]; other site 675635009657 catalytic residues [active] 675635009658 substrate-Mg2+ binding site; other site 675635009659 aspartate-rich region 1; other site 675635009660 aspartate-rich region 2; other site 675635009661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 675635009662 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 675635009663 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 675635009664 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 675635009665 substrate binding pocket [chemical binding]; other site 675635009666 chain length determination region; other site 675635009667 substrate-Mg2+ binding site; other site 675635009668 catalytic residues [active] 675635009669 aspartate-rich region 1; other site 675635009670 active site lid residues [active] 675635009671 aspartate-rich region 2; other site 675635009672 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 675635009673 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 675635009674 Active site cavity [active] 675635009675 catalytic acid [active] 675635009676 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 675635009677 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 675635009678 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 675635009679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635009680 FeS/SAM binding site; other site 675635009681 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 675635009682 Intracellular septation protein A; Region: IspA; cl01098 675635009683 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 675635009684 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635009685 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 675635009686 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 675635009687 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 675635009688 classical (c) SDRs; Region: SDR_c; cd05233 675635009689 NAD(P) binding site [chemical binding]; other site 675635009690 active site 675635009691 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 675635009692 Dehydroquinase class II; Region: DHquinase_II; pfam01220 675635009693 trimer interface [polypeptide binding]; other site 675635009694 active site 675635009695 dimer interface [polypeptide binding]; other site 675635009696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 675635009697 Coenzyme A binding pocket [chemical binding]; other site 675635009698 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635009699 MarR family; Region: MarR; pfam01047 675635009700 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635009701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009702 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635009703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635009704 Walker A/P-loop; other site 675635009705 ATP binding site [chemical binding]; other site 675635009706 Q-loop/lid; other site 675635009707 ABC transporter signature motif; other site 675635009708 Walker B; other site 675635009709 D-loop; other site 675635009710 H-loop/switch region; other site 675635009711 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 675635009712 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635009713 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635009714 Walker A/P-loop; other site 675635009715 ATP binding site [chemical binding]; other site 675635009716 Q-loop/lid; other site 675635009717 ABC transporter signature motif; other site 675635009718 Walker B; other site 675635009719 D-loop; other site 675635009720 H-loop/switch region; other site 675635009721 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 675635009722 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635009723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635009724 dimer interface [polypeptide binding]; other site 675635009725 conserved gate region; other site 675635009726 putative PBP binding loops; other site 675635009727 ABC-ATPase subunit interface; other site 675635009728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635009729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635009730 dimer interface [polypeptide binding]; other site 675635009731 conserved gate region; other site 675635009732 putative PBP binding loops; other site 675635009733 ABC-ATPase subunit interface; other site 675635009734 Ferredoxin [Energy production and conversion]; Region: COG1146 675635009735 4Fe-4S binding domain; Region: Fer4; pfam00037 675635009736 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635009737 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635009738 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 675635009739 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635009740 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635009741 hydrophobic ligand binding site; other site 675635009742 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 675635009743 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 675635009744 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635009745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635009746 DNA-binding site [nucleotide binding]; DNA binding site 675635009747 FCD domain; Region: FCD; pfam07729 675635009748 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635009749 substrate binding site [chemical binding]; other site 675635009750 THF binding site; other site 675635009751 zinc-binding site [ion binding]; other site 675635009752 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635009753 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 675635009754 Muconolactone delta-isomerase; Region: MIase; pfam02426 675635009755 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 675635009756 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635009757 PYR/PP interface [polypeptide binding]; other site 675635009758 dimer interface [polypeptide binding]; other site 675635009759 TPP binding site [chemical binding]; other site 675635009760 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 675635009761 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635009762 TPP-binding site [chemical binding]; other site 675635009763 short chain dehydrogenase; Validated; Region: PRK05855 675635009764 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635009765 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 675635009766 alpha subunit interface [polypeptide binding]; other site 675635009767 TPP binding site [chemical binding]; other site 675635009768 heterodimer interface [polypeptide binding]; other site 675635009769 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635009770 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635009771 tetramer interface [polypeptide binding]; other site 675635009772 TPP-binding site [chemical binding]; other site 675635009773 heterodimer interface [polypeptide binding]; other site 675635009774 phosphorylation loop region [posttranslational modification] 675635009775 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635009776 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 675635009777 PYR/PP interface [polypeptide binding]; other site 675635009778 dimer interface [polypeptide binding]; other site 675635009779 TPP binding site [chemical binding]; other site 675635009780 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635009781 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 675635009782 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635009783 tetramer interface [polypeptide binding]; other site 675635009784 TPP-binding site [chemical binding]; other site 675635009785 heterodimer interface [polypeptide binding]; other site 675635009786 phosphorylation loop region [posttranslational modification] 675635009787 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635009788 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635009789 E3 interaction surface; other site 675635009790 lipoyl attachment site [posttranslational modification]; other site 675635009791 e3 binding domain; Region: E3_binding; pfam02817 675635009792 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 675635009793 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 675635009794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635009795 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635009796 NAD(P) binding site [chemical binding]; other site 675635009797 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 675635009798 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 675635009799 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 675635009800 dimerization interface [polypeptide binding]; other site 675635009801 NAD binding site [chemical binding]; other site 675635009802 ligand binding site [chemical binding]; other site 675635009803 catalytic site [active] 675635009804 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635009805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635009806 putative DNA binding site [nucleotide binding]; other site 675635009807 putative Zn2+ binding site [ion binding]; other site 675635009808 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635009809 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635009810 classical (c) SDRs; Region: SDR_c; cd05233 675635009811 NAD(P) binding site [chemical binding]; other site 675635009812 active site 675635009813 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 675635009814 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 675635009815 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 675635009816 active site 675635009817 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 675635009818 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 675635009819 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635009820 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 675635009821 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 675635009822 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635009823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635009824 NAD(P) binding site [chemical binding]; other site 675635009825 active site 675635009826 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635009827 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635009828 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 675635009829 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 675635009830 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635009831 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 675635009832 alpha subunit interface [polypeptide binding]; other site 675635009833 TPP binding site [chemical binding]; other site 675635009834 heterodimer interface [polypeptide binding]; other site 675635009835 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635009836 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635009837 tetramer interface [polypeptide binding]; other site 675635009838 TPP-binding site [chemical binding]; other site 675635009839 heterodimer interface [polypeptide binding]; other site 675635009840 phosphorylation loop region [posttranslational modification] 675635009841 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635009842 classical (c) SDRs; Region: SDR_c; cd05233 675635009843 NAD(P) binding site [chemical binding]; other site 675635009844 active site 675635009845 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635009846 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 675635009847 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635009848 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 675635009849 Walker A/P-loop; other site 675635009850 ATP binding site [chemical binding]; other site 675635009851 Q-loop/lid; other site 675635009852 ABC transporter signature motif; other site 675635009853 Walker B; other site 675635009854 D-loop; other site 675635009855 H-loop/switch region; other site 675635009856 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635009857 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 675635009858 Walker A/P-loop; other site 675635009859 ATP binding site [chemical binding]; other site 675635009860 Q-loop/lid; other site 675635009861 ABC transporter signature motif; other site 675635009862 Walker B; other site 675635009863 D-loop; other site 675635009864 H-loop/switch region; other site 675635009865 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 675635009866 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635009867 TM-ABC transporter signature motif; other site 675635009868 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635009869 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635009870 TM-ABC transporter signature motif; other site 675635009871 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 675635009872 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635009873 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635009874 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 675635009875 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 675635009876 active site 675635009877 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 675635009878 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 675635009879 DUF35 OB-fold domain; Region: DUF35; pfam01796 675635009880 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 675635009881 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635009882 NAD(P) binding site [chemical binding]; other site 675635009883 AMP-binding domain protein; Validated; Region: PRK08315 675635009884 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635009885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635009886 acyl-activating enzyme (AAE) consensus motif; other site 675635009887 AMP binding site [chemical binding]; other site 675635009888 active site 675635009889 CoA binding site [chemical binding]; other site 675635009890 Putative cyclase; Region: Cyclase; pfam04199 675635009891 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635009892 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635009893 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635009894 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 675635009895 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635009896 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 675635009897 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635009898 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635009899 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 675635009900 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 675635009901 tyramine oxidase; Provisional; Region: tynA; PRK11504 675635009902 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 675635009903 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 675635009904 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 675635009905 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635009906 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635009907 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635009908 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635009909 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635009910 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635009911 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635009912 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635009913 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635009914 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635009915 hydrophobic ligand binding site; other site 675635009916 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 675635009917 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635009918 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635009919 putative sialic acid transporter; Region: 2A0112; TIGR00891 675635009920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009921 putative substrate translocation pore; other site 675635009922 benzoate transport; Region: 2A0115; TIGR00895 675635009923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635009924 putative substrate translocation pore; other site 675635009925 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 675635009926 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 675635009927 active site 675635009928 FMN binding site [chemical binding]; other site 675635009929 substrate binding site [chemical binding]; other site 675635009930 3Fe-4S cluster binding site [ion binding]; other site 675635009931 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 675635009932 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 675635009933 tetrameric interface [polypeptide binding]; other site 675635009934 NAD binding site [chemical binding]; other site 675635009935 catalytic residues [active] 675635009936 short chain dehydrogenase; Provisional; Region: PRK06180 675635009937 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 675635009938 NADP binding site [chemical binding]; other site 675635009939 active site 675635009940 steroid binding site; other site 675635009941 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635009942 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 675635009943 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 675635009944 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635009945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635009946 DNA-binding site [nucleotide binding]; DNA binding site 675635009947 FCD domain; Region: FCD; pfam07729 675635009948 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635009949 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 675635009950 putative NAD(P) binding site [chemical binding]; other site 675635009951 active site 675635009952 putative substrate binding site [chemical binding]; other site 675635009953 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 675635009954 Cation efflux family; Region: Cation_efflux; cl00316 675635009955 YCII-related domain; Region: YCII; cl00999 675635009956 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 675635009957 putative hydrophobic ligand binding site [chemical binding]; other site 675635009958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635009959 dimerization interface [polypeptide binding]; other site 675635009960 putative DNA binding site [nucleotide binding]; other site 675635009961 putative Zn2+ binding site [ion binding]; other site 675635009962 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635009963 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635009964 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635009965 DNA binding residues [nucleotide binding] 675635009966 YCII-related domain; Region: YCII; cl00999 675635009967 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 675635009968 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635009969 active site 675635009970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635009971 DNA polymerase IV; Validated; Region: PRK03858 675635009972 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 675635009973 active site 675635009974 DNA binding site [nucleotide binding] 675635009975 Predicted transcriptional regulators [Transcription]; Region: COG1695 675635009976 Transcriptional regulator PadR-like family; Region: PadR; cl17335 675635009977 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 675635009978 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 675635009979 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635009980 F420H2 dehydrogenase subunit FpoO; Region: FpoO; pfam10621 675635009981 MULE transposase domain; Region: MULE; pfam10551 675635009982 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635009983 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635009984 NAD synthetase; Reviewed; Region: nadE; PRK02628 675635009985 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 675635009986 multimer interface [polypeptide binding]; other site 675635009987 active site 675635009988 catalytic triad [active] 675635009989 protein interface 1 [polypeptide binding]; other site 675635009990 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 675635009991 homodimer interface [polypeptide binding]; other site 675635009992 NAD binding pocket [chemical binding]; other site 675635009993 ATP binding pocket [chemical binding]; other site 675635009994 Mg binding site [ion binding]; other site 675635009995 active-site loop [active] 675635009996 Predicted membrane protein [Function unknown]; Region: COG2860 675635009997 FOG: CBS domain [General function prediction only]; Region: COG0517 675635009998 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 675635009999 FOG: CBS domain [General function prediction only]; Region: COG0517 675635010000 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635010001 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 675635010002 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635010003 Cytochrome P450; Region: p450; cl12078 675635010004 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 675635010005 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 675635010006 putative active site [active] 675635010007 putative metal binding site [ion binding]; other site 675635010008 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635010009 SnoaL-like domain; Region: SnoaL_3; pfam13474 675635010010 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 675635010011 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010012 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635010013 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635010014 DNA binding residues [nucleotide binding] 675635010015 dimerization interface [polypeptide binding]; other site 675635010016 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635010017 Methyltransferase domain; Region: Methyltransf_11; pfam08241 675635010018 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 675635010019 RibD C-terminal domain; Region: RibD_C; cl17279 675635010020 Predicted transcriptional regulators [Transcription]; Region: COG1733 675635010021 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 675635010022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635010023 S-adenosylmethionine binding site [chemical binding]; other site 675635010024 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 675635010025 hypothetical protein; Validated; Region: PRK07581 675635010026 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 675635010027 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 675635010028 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635010029 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 675635010030 putative ligand binding site [chemical binding]; other site 675635010031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635010032 MarR family; Region: MarR_2; cl17246 675635010033 GTP-binding protein Der; Reviewed; Region: PRK03003 675635010034 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 675635010035 G1 box; other site 675635010036 GTP/Mg2+ binding site [chemical binding]; other site 675635010037 Switch I region; other site 675635010038 G2 box; other site 675635010039 Switch II region; other site 675635010040 G3 box; other site 675635010041 G4 box; other site 675635010042 G5 box; other site 675635010043 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 675635010044 G1 box; other site 675635010045 GTP/Mg2+ binding site [chemical binding]; other site 675635010046 Switch I region; other site 675635010047 G2 box; other site 675635010048 G3 box; other site 675635010049 Switch II region; other site 675635010050 G4 box; other site 675635010051 G5 box; other site 675635010052 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 675635010053 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635010054 putative acyl-acceptor binding pocket; other site 675635010055 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 675635010056 cytidylate kinase; Region: cmk; TIGR00017 675635010057 CMP-binding site; other site 675635010058 The sites determining sugar specificity; other site 675635010059 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 675635010060 homotrimer interaction site [polypeptide binding]; other site 675635010061 active site 675635010062 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 675635010063 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 675635010064 RNA binding surface [nucleotide binding]; other site 675635010065 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 675635010066 active site 675635010067 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 675635010068 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 675635010069 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635010070 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635010071 P-loop; other site 675635010072 Magnesium ion binding site [ion binding]; other site 675635010073 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635010074 Magnesium ion binding site [ion binding]; other site 675635010075 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 675635010076 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635010077 active site 675635010078 DNA binding site [nucleotide binding] 675635010079 Int/Topo IB signature motif; other site 675635010080 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010081 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635010082 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 675635010083 dimer interface [polypeptide binding]; other site 675635010084 ADP-ribose binding site [chemical binding]; other site 675635010085 active site 675635010086 nudix motif; other site 675635010087 metal binding site [ion binding]; metal-binding site 675635010088 CTP synthetase; Validated; Region: pyrG; PRK05380 675635010089 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 675635010090 Catalytic site [active] 675635010091 active site 675635010092 UTP binding site [chemical binding]; other site 675635010093 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 675635010094 active site 675635010095 putative oxyanion hole; other site 675635010096 catalytic triad [active] 675635010097 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 675635010098 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 675635010099 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 675635010100 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 675635010101 Walker A/P-loop; other site 675635010102 ATP binding site [chemical binding]; other site 675635010103 Q-loop/lid; other site 675635010104 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 675635010105 ABC transporter signature motif; other site 675635010106 Walker B; other site 675635010107 D-loop; other site 675635010108 H-loop/switch region; other site 675635010109 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 675635010110 ATP-NAD kinase; Region: NAD_kinase; pfam01513 675635010111 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 675635010112 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 675635010113 RNA binding surface [nucleotide binding]; other site 675635010114 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 675635010115 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 675635010116 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 675635010117 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 675635010118 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 675635010119 active site 675635010120 DNA binding site [nucleotide binding] 675635010121 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 675635010122 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635010123 DNA binding residues [nucleotide binding] 675635010124 dimer interface [polypeptide binding]; other site 675635010125 argininosuccinate lyase; Provisional; Region: PRK00855 675635010126 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 675635010127 active sites [active] 675635010128 tetramer interface [polypeptide binding]; other site 675635010129 argininosuccinate synthase; Validated; Region: PRK05370 675635010130 arginine repressor; Provisional; Region: PRK03341 675635010131 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 675635010132 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 675635010133 ornithine carbamoyltransferase; Provisional; Region: PRK00779 675635010134 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 675635010135 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 675635010136 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 675635010137 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635010138 inhibitor-cofactor binding pocket; inhibition site 675635010139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635010140 catalytic residue [active] 675635010141 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 675635010142 feedback inhibition sensing region; other site 675635010143 homohexameric interface [polypeptide binding]; other site 675635010144 nucleotide binding site [chemical binding]; other site 675635010145 N-acetyl-L-glutamate binding site [chemical binding]; other site 675635010146 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 675635010147 heterotetramer interface [polypeptide binding]; other site 675635010148 active site pocket [active] 675635010149 cleavage site 675635010150 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 675635010151 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 675635010152 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 675635010153 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 675635010154 active site 675635010155 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 675635010156 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 675635010157 putative tRNA-binding site [nucleotide binding]; other site 675635010158 B3/4 domain; Region: B3_4; pfam03483 675635010159 tRNA synthetase B5 domain; Region: B5; smart00874 675635010160 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 675635010161 dimer interface [polypeptide binding]; other site 675635010162 motif 1; other site 675635010163 motif 3; other site 675635010164 motif 2; other site 675635010165 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 675635010166 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 675635010167 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 675635010168 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 675635010169 dimer interface [polypeptide binding]; other site 675635010170 motif 1; other site 675635010171 active site 675635010172 motif 2; other site 675635010173 motif 3; other site 675635010174 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 675635010175 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 675635010176 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 675635010177 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 675635010178 23S rRNA binding site [nucleotide binding]; other site 675635010179 L21 binding site [polypeptide binding]; other site 675635010180 L13 binding site [polypeptide binding]; other site 675635010181 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 675635010182 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 675635010183 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 675635010184 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 675635010185 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 675635010186 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 675635010187 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 675635010188 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 675635010189 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635010190 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635010191 hydrophobic ligand binding site; other site 675635010192 Transcriptional regulator [Transcription]; Region: LytR; COG1316 675635010193 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 675635010194 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635010195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010196 putative substrate translocation pore; other site 675635010197 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 675635010198 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 675635010199 active site 675635010200 metal binding site [ion binding]; metal-binding site 675635010201 homotetramer interface [polypeptide binding]; other site 675635010202 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 675635010203 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635010204 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 675635010205 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635010206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635010207 Walker A/P-loop; other site 675635010208 ATP binding site [chemical binding]; other site 675635010209 Q-loop/lid; other site 675635010210 ABC transporter signature motif; other site 675635010211 Walker B; other site 675635010212 D-loop; other site 675635010213 H-loop/switch region; other site 675635010214 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 675635010215 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 675635010216 EamA-like transporter family; Region: EamA; pfam00892 675635010217 EamA-like transporter family; Region: EamA; pfam00892 675635010218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635010219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635010220 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635010221 dimerization interface [polypeptide binding]; other site 675635010222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635010223 Predicted membrane protein [Function unknown]; Region: COG4270 675635010224 Protein of unknown function (DUF419); Region: DUF419; pfam04237 675635010225 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 675635010226 excinuclease ABC subunit B; Provisional; Region: PRK05298 675635010227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635010228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635010229 nucleotide binding region [chemical binding]; other site 675635010230 ATP-binding site [chemical binding]; other site 675635010231 Ultra-violet resistance protein B; Region: UvrB; pfam12344 675635010232 UvrB/uvrC motif; Region: UVR; pfam02151 675635010233 Protein of unknown function (DUF402); Region: DUF402; cl00979 675635010234 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 675635010235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635010236 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635010237 DNA binding residues [nucleotide binding] 675635010238 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 675635010239 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 675635010240 CoA-binding site [chemical binding]; other site 675635010241 ATP-binding [chemical binding]; other site 675635010242 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 675635010243 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 675635010244 RNA binding site [nucleotide binding]; other site 675635010245 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 675635010246 RNA binding site [nucleotide binding]; other site 675635010247 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 675635010248 RNA binding site [nucleotide binding]; other site 675635010249 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 675635010250 RNA binding site [nucleotide binding]; other site 675635010251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635010252 S-adenosylmethionine binding site [chemical binding]; other site 675635010253 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635010254 CoenzymeA binding site [chemical binding]; other site 675635010255 subunit interaction site [polypeptide binding]; other site 675635010256 PHB binding site; other site 675635010257 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 675635010258 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 675635010259 dimerization interface [polypeptide binding]; other site 675635010260 ligand binding site [chemical binding]; other site 675635010261 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635010262 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635010263 TM-ABC transporter signature motif; other site 675635010264 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635010265 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635010266 TM-ABC transporter signature motif; other site 675635010267 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 675635010268 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 675635010269 Walker A/P-loop; other site 675635010270 ATP binding site [chemical binding]; other site 675635010271 Q-loop/lid; other site 675635010272 ABC transporter signature motif; other site 675635010273 Walker B; other site 675635010274 D-loop; other site 675635010275 H-loop/switch region; other site 675635010276 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 675635010277 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 675635010278 Walker A/P-loop; other site 675635010279 ATP binding site [chemical binding]; other site 675635010280 Q-loop/lid; other site 675635010281 ABC transporter signature motif; other site 675635010282 Walker B; other site 675635010283 D-loop; other site 675635010284 H-loop/switch region; other site 675635010285 Response regulator receiver domain; Region: Response_reg; pfam00072 675635010286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635010287 active site 675635010288 phosphorylation site [posttranslational modification] 675635010289 intermolecular recognition site; other site 675635010290 dimerization interface [polypeptide binding]; other site 675635010291 ANTAR domain; Region: ANTAR; pfam03861 675635010292 Right handed beta helix region; Region: Beta_helix; pfam13229 675635010293 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 675635010294 active site 675635010295 acceptor substrate-binding pocket; other site 675635010296 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635010297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635010298 active site 675635010299 phosphorylation site [posttranslational modification] 675635010300 intermolecular recognition site; other site 675635010301 dimerization interface [polypeptide binding]; other site 675635010302 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635010303 DNA binding residues [nucleotide binding] 675635010304 dimerization interface [polypeptide binding]; other site 675635010305 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635010306 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 675635010307 catalytic residues [active] 675635010308 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635010309 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635010310 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635010311 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635010312 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635010313 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 675635010314 glyoxylate carboligase; Provisional; Region: PRK11269 675635010315 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635010316 PYR/PP interface [polypeptide binding]; other site 675635010317 dimer interface [polypeptide binding]; other site 675635010318 TPP binding site [chemical binding]; other site 675635010319 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 675635010320 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635010321 TPP-binding site [chemical binding]; other site 675635010322 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 675635010323 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635010324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635010325 DNA-binding site [nucleotide binding]; DNA binding site 675635010326 UTRA domain; Region: UTRA; pfam07702 675635010327 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 675635010328 Aminotransferase class IV; Region: Aminotran_4; pfam01063 675635010329 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 675635010330 substrate-cofactor binding pocket; other site 675635010331 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 675635010332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 675635010333 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 675635010334 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 675635010335 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 675635010336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635010337 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 675635010338 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635010339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010340 NAD(P) binding site [chemical binding]; other site 675635010341 active site 675635010342 acyl-CoA synthetase; Validated; Region: PRK06188 675635010343 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635010344 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635010345 acyl-activating enzyme (AAE) consensus motif; other site 675635010346 acyl-activating enzyme (AAE) consensus motif; other site 675635010347 putative AMP binding site [chemical binding]; other site 675635010348 putative active site [active] 675635010349 putative CoA binding site [chemical binding]; other site 675635010350 Predicted transcriptional regulators [Transcription]; Region: COG1695 675635010351 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635010352 putative DNA binding site [nucleotide binding]; other site 675635010353 putative Zn2+ binding site [ion binding]; other site 675635010354 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 675635010355 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 675635010356 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635010357 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 675635010358 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635010359 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010360 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635010361 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635010362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635010363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635010364 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635010365 dimerization interface [polypeptide binding]; other site 675635010366 substrate binding pocket [chemical binding]; other site 675635010367 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 675635010368 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 675635010369 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 675635010370 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 675635010371 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 675635010372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635010373 Coenzyme A binding pocket [chemical binding]; other site 675635010374 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635010375 Methyltransferase domain; Region: Methyltransf_18; pfam12847 675635010376 AAA ATPase domain; Region: AAA_16; pfam13191 675635010377 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635010378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635010379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635010380 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635010381 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635010382 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 675635010383 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635010384 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635010385 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635010386 FAD binding domain; Region: FAD_binding_4; pfam01565 675635010387 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635010388 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635010389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635010390 DNA-binding site [nucleotide binding]; DNA binding site 675635010391 FCD domain; Region: FCD; pfam07729 675635010392 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 675635010393 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635010394 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 675635010395 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635010396 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635010397 hydrophobic ligand binding site; other site 675635010398 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 675635010399 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 675635010400 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635010401 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635010402 hydrophobic ligand binding site; other site 675635010403 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635010404 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635010405 NAD(P) binding site [chemical binding]; other site 675635010406 hypothetical protein; Provisional; Region: PRK06154 675635010407 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635010408 PYR/PP interface [polypeptide binding]; other site 675635010409 dimer interface [polypeptide binding]; other site 675635010410 TPP binding site [chemical binding]; other site 675635010411 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 675635010412 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 675635010413 TPP-binding site; other site 675635010414 dimer interface [polypeptide binding]; other site 675635010415 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635010416 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635010417 D-galactonate transporter; Region: 2A0114; TIGR00893 675635010418 PAC2 family; Region: PAC2; pfam09754 675635010419 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635010420 TPP-binding site [chemical binding]; other site 675635010421 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 675635010422 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 675635010423 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635010424 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 675635010425 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635010426 AsnC family; Region: AsnC_trans_reg; pfam01037 675635010427 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 675635010428 Beta-lactamase; Region: Beta-lactamase; pfam00144 675635010429 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635010430 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 675635010431 NAD(P) binding site [chemical binding]; other site 675635010432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010433 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635010434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635010435 DNA-binding site [nucleotide binding]; DNA binding site 675635010436 FCD domain; Region: FCD; pfam07729 675635010437 DNA polymerase IV; Validated; Region: PRK03352 675635010438 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 675635010439 active site 675635010440 DNA binding site [nucleotide binding] 675635010441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 675635010442 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 675635010443 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635010444 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 675635010445 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 675635010446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635010447 Walker A/P-loop; other site 675635010448 ATP binding site [chemical binding]; other site 675635010449 Q-loop/lid; other site 675635010450 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 675635010451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635010452 ABC transporter signature motif; other site 675635010453 Walker B; other site 675635010454 D-loop; other site 675635010455 H-loop/switch region; other site 675635010456 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 675635010457 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 675635010458 active site 675635010459 metal binding site [ion binding]; metal-binding site 675635010460 DNA binding site [nucleotide binding] 675635010461 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 675635010462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635010463 Integrase core domain; Region: rve; pfam00665 675635010464 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635010465 active site 675635010466 catalytic residues [active] 675635010467 DNA binding site [nucleotide binding] 675635010468 Int/Topo IB signature motif; other site 675635010469 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 675635010470 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 675635010471 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635010472 active site 675635010473 catalytic residues [active] 675635010474 DNA binding site [nucleotide binding] 675635010475 Int/Topo IB signature motif; other site 675635010476 Domain of unknown function DUF302; Region: DUF302; cl01364 675635010477 HerA helicase [Replication, recombination, and repair]; Region: COG0433 675635010478 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 675635010479 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 675635010480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635010481 FeS/SAM binding site; other site 675635010482 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 675635010483 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 675635010484 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635010485 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635010486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 675635010487 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635010488 TIGR03086 family protein; Region: TIGR03086 675635010489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635010490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 675635010491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635010492 dimer interface [polypeptide binding]; other site 675635010493 phosphorylation site [posttranslational modification] 675635010494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635010495 ATP binding site [chemical binding]; other site 675635010496 Mg2+ binding site [ion binding]; other site 675635010497 G-X-G motif; other site 675635010498 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635010499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635010500 active site 675635010501 phosphorylation site [posttranslational modification] 675635010502 intermolecular recognition site; other site 675635010503 dimerization interface [polypeptide binding]; other site 675635010504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635010505 DNA binding site [nucleotide binding] 675635010506 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 675635010507 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 675635010508 Walker A/P-loop; other site 675635010509 ATP binding site [chemical binding]; other site 675635010510 Q-loop/lid; other site 675635010511 ABC transporter signature motif; other site 675635010512 Walker B; other site 675635010513 D-loop; other site 675635010514 H-loop/switch region; other site 675635010515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 675635010516 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 675635010517 substrate binding pocket [chemical binding]; other site 675635010518 membrane-bound complex binding site; other site 675635010519 hinge residues; other site 675635010520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635010521 dimer interface [polypeptide binding]; other site 675635010522 conserved gate region; other site 675635010523 putative PBP binding loops; other site 675635010524 ABC-ATPase subunit interface; other site 675635010525 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 675635010526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635010527 dimer interface [polypeptide binding]; other site 675635010528 conserved gate region; other site 675635010529 putative PBP binding loops; other site 675635010530 ABC-ATPase subunit interface; other site 675635010531 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 675635010532 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 675635010533 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 675635010534 metal binding triad; other site 675635010535 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 675635010536 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 675635010537 metal binding triad; other site 675635010538 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 675635010539 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 675635010540 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 675635010541 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 675635010542 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 675635010543 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635010544 TAP-like protein; Region: Abhydrolase_4; pfam08386 675635010545 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 675635010546 oligomerization interface [polypeptide binding]; other site 675635010547 active site 675635010548 metal binding site [ion binding]; metal-binding site 675635010549 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 675635010550 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 675635010551 putative FMN binding site [chemical binding]; other site 675635010552 RNB domain; Region: RNB; pfam00773 675635010553 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 675635010554 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 675635010555 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 675635010556 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 675635010557 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635010558 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 675635010559 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635010560 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635010561 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635010562 fumarate hydratase; Provisional; Region: PRK15389 675635010563 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 675635010564 Fumarase C-terminus; Region: Fumerase_C; pfam05683 675635010565 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 675635010566 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 675635010567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635010568 Coenzyme A binding pocket [chemical binding]; other site 675635010569 CoA binding domain; Region: CoA_binding_2; pfam13380 675635010570 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 675635010571 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 675635010572 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 675635010573 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 675635010574 active site 675635010575 Zn binding site [ion binding]; other site 675635010576 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 675635010577 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 675635010578 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 675635010579 FeoA domain; Region: FeoA; pfam04023 675635010580 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 675635010581 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 675635010582 NAD binding site [chemical binding]; other site 675635010583 homodimer interface [polypeptide binding]; other site 675635010584 active site 675635010585 substrate binding site [chemical binding]; other site 675635010586 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 675635010587 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 675635010588 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635010589 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 675635010590 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 675635010591 dimer interface [polypeptide binding]; other site 675635010592 PYR/PP interface [polypeptide binding]; other site 675635010593 TPP binding site [chemical binding]; other site 675635010594 substrate binding site [chemical binding]; other site 675635010595 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635010596 TPP-binding site [chemical binding]; other site 675635010597 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 675635010598 acyl-CoA synthetase; Validated; Region: PRK08162 675635010599 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 675635010600 acyl-activating enzyme (AAE) consensus motif; other site 675635010601 putative active site [active] 675635010602 AMP binding site [chemical binding]; other site 675635010603 putative CoA binding site [chemical binding]; other site 675635010604 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 675635010605 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 675635010606 Lsr2; Region: Lsr2; pfam11774 675635010607 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 675635010608 classical (c) SDRs; Region: SDR_c; cd05233 675635010609 NAD(P) binding site [chemical binding]; other site 675635010610 active site 675635010611 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635010612 tyrosine decarboxylase; Region: PLN02880 675635010613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635010614 catalytic residue [active] 675635010615 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 675635010616 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 675635010617 siderophore binding site; other site 675635010618 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 675635010619 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 675635010620 active site 675635010621 substrate binding site [chemical binding]; other site 675635010622 cosubstrate binding site; other site 675635010623 catalytic site [active] 675635010624 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 675635010625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635010626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635010627 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635010628 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635010629 active site 675635010630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010631 NAD(P) binding site [chemical binding]; other site 675635010632 active site 675635010633 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 675635010634 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635010635 dimer interface [polypeptide binding]; other site 675635010636 active site 675635010637 MarR family; Region: MarR; pfam01047 675635010638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010639 putative substrate translocation pore; other site 675635010640 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635010641 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635010642 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635010643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635010644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635010645 active site 675635010646 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 675635010647 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635010648 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635010649 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635010650 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 675635010651 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 675635010652 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 675635010653 oxyanion hole (OAH) forming residues; other site 675635010654 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 675635010655 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635010656 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635010657 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635010658 active site 675635010659 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635010660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635010661 active site 675635010662 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635010663 Ligand Binding Site [chemical binding]; other site 675635010664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010665 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635010666 putative substrate translocation pore; other site 675635010667 MarR family; Region: MarR; pfam01047 675635010668 Uncharacterized conserved protein (DUF2039); Region: DUF2039; pfam10217 675635010669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010671 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 675635010672 active site 675635010673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010674 active site 675635010675 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 675635010676 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 675635010677 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 675635010678 Family description; Region: UvrD_C_2; pfam13538 675635010679 AAA domain; Region: AAA_30; pfam13604 675635010680 Family description; Region: UvrD_C_2; pfam13538 675635010681 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 675635010682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635010683 active site 675635010684 phosphorylation site [posttranslational modification] 675635010685 intermolecular recognition site; other site 675635010686 dimerization interface [polypeptide binding]; other site 675635010687 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 675635010688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635010689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635010690 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635010691 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635010692 ligand binding site [chemical binding]; other site 675635010693 flexible hinge region; other site 675635010694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635010695 ATP binding site [chemical binding]; other site 675635010696 Mg2+ binding site [ion binding]; other site 675635010697 G-X-G motif; other site 675635010698 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 675635010699 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 675635010700 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 675635010701 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 675635010702 homodimer interface [polypeptide binding]; other site 675635010703 NADP binding site [chemical binding]; other site 675635010704 substrate binding site [chemical binding]; other site 675635010705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010706 putative substrate translocation pore; other site 675635010707 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 675635010708 AAA ATPase domain; Region: AAA_16; pfam13191 675635010709 AzlC protein; Region: AzlC; pfam03591 675635010710 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635010711 MarR family; Region: MarR_2; pfam12802 675635010712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010713 NAD(P) binding site [chemical binding]; other site 675635010714 active site 675635010715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635010716 DNA-binding site [nucleotide binding]; DNA binding site 675635010717 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 675635010718 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 675635010719 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 675635010720 Cysteine-rich domain; Region: CCG; pfam02754 675635010721 Cysteine-rich domain; Region: CCG; pfam02754 675635010722 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 675635010723 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 675635010724 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 675635010725 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 675635010726 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 675635010727 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 675635010728 putative ADP-ribose binding site [chemical binding]; other site 675635010729 putative active site [active] 675635010730 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 675635010731 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 675635010732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635010733 catalytic residue [active] 675635010734 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 675635010735 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010736 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635010737 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010738 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 675635010739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010740 putative substrate translocation pore; other site 675635010741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010742 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 675635010743 hypothetical protein; Provisional; Region: PRK06815 675635010744 tetramer interface [polypeptide binding]; other site 675635010745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635010746 catalytic residue [active] 675635010747 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 675635010748 B12 binding domain; Region: B12-binding_2; pfam02607 675635010749 B12 binding domain; Region: B12-binding; pfam02310 675635010750 B12 binding site [chemical binding]; other site 675635010751 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 675635010752 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 675635010753 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 675635010754 probable active site [active] 675635010755 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 675635010756 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 675635010757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635010758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635010759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635010760 dimerization interface [polypeptide binding]; other site 675635010761 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 675635010762 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 675635010763 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635010764 phosphate binding site [ion binding]; other site 675635010765 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 675635010766 Beta-lactamase; Region: Beta-lactamase; pfam00144 675635010767 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 675635010768 Predicted membrane protein [Function unknown]; Region: COG1289 675635010769 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 675635010770 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635010771 HTH domain; Region: HTH_11; pfam08279 675635010772 WYL domain; Region: WYL; pfam13280 675635010773 hypothetical protein; Provisional; Region: PRK01842 675635010774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635010775 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 675635010776 Walker A/P-loop; other site 675635010777 ATP binding site [chemical binding]; other site 675635010778 Q-loop/lid; other site 675635010779 ABC transporter signature motif; other site 675635010780 Walker B; other site 675635010781 D-loop; other site 675635010782 H-loop/switch region; other site 675635010783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635010784 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635010785 Walker A/P-loop; other site 675635010786 ATP binding site [chemical binding]; other site 675635010787 Q-loop/lid; other site 675635010788 ABC transporter signature motif; other site 675635010789 Walker B; other site 675635010790 D-loop; other site 675635010791 H-loop/switch region; other site 675635010792 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 675635010793 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 675635010794 Domain of unknown function (DUF385); Region: DUF385; pfam04075 675635010795 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 675635010796 Peptidase family M28; Region: Peptidase_M28; pfam04389 675635010797 metal binding site [ion binding]; metal-binding site 675635010798 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 675635010799 PLD-like domain; Region: PLDc_2; pfam13091 675635010800 putative homodimer interface [polypeptide binding]; other site 675635010801 putative active site [active] 675635010802 catalytic site [active] 675635010803 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 675635010804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635010805 nucleotide binding region [chemical binding]; other site 675635010806 ATP-binding site [chemical binding]; other site 675635010807 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 675635010808 CGNR zinc finger; Region: zf-CGNR; pfam11706 675635010809 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635010810 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 675635010811 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 675635010812 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635010813 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 675635010814 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 675635010815 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635010816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010817 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 675635010818 putative hydrophobic ligand binding site [chemical binding]; other site 675635010819 CLM binding site; other site 675635010820 DNA binding site [nucleotide binding] 675635010821 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635010822 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635010823 active site 675635010824 catalytic tetrad [active] 675635010825 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 675635010826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635010827 S-adenosylmethionine binding site [chemical binding]; other site 675635010828 PAS domain S-box; Region: sensory_box; TIGR00229 675635010829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635010830 putative active site [active] 675635010831 heme pocket [chemical binding]; other site 675635010832 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 675635010833 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635010834 metal binding site [ion binding]; metal-binding site 675635010835 active site 675635010836 I-site; other site 675635010837 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 675635010838 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 675635010839 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 675635010840 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 675635010841 classical (c) SDRs; Region: SDR_c; cd05233 675635010842 NAD(P) binding site [chemical binding]; other site 675635010843 active site 675635010844 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635010845 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010846 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 675635010847 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635010848 Walker A/P-loop; other site 675635010849 ATP binding site [chemical binding]; other site 675635010850 Q-loop/lid; other site 675635010851 ABC transporter signature motif; other site 675635010852 Walker B; other site 675635010853 D-loop; other site 675635010854 H-loop/switch region; other site 675635010855 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 675635010856 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635010857 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635010858 Walker A/P-loop; other site 675635010859 ATP binding site [chemical binding]; other site 675635010860 Q-loop/lid; other site 675635010861 ABC transporter signature motif; other site 675635010862 Walker B; other site 675635010863 D-loop; other site 675635010864 H-loop/switch region; other site 675635010865 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 675635010866 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635010867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635010868 dimer interface [polypeptide binding]; other site 675635010869 conserved gate region; other site 675635010870 putative PBP binding loops; other site 675635010871 ABC-ATPase subunit interface; other site 675635010872 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 675635010873 peptide binding site [polypeptide binding]; other site 675635010874 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 675635010875 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 675635010876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635010877 putative PBP binding loops; other site 675635010878 dimer interface [polypeptide binding]; other site 675635010879 ABC-ATPase subunit interface; other site 675635010880 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635010881 hydrophobic ligand binding site; other site 675635010882 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 675635010883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010884 NAD(P) binding site [chemical binding]; other site 675635010885 active site 675635010886 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 675635010887 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 675635010888 acyl-activating enzyme (AAE) consensus motif; other site 675635010889 putative AMP binding site [chemical binding]; other site 675635010890 putative active site [active] 675635010891 putative CoA binding site [chemical binding]; other site 675635010892 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635010893 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635010895 enoyl-CoA hydratase; Provisional; Region: PRK07799 675635010896 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635010897 substrate binding site [chemical binding]; other site 675635010898 oxyanion hole (OAH) forming residues; other site 675635010899 trimer interface [polypeptide binding]; other site 675635010900 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 675635010901 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635010902 active site 675635010903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010904 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635010905 NAD(P) binding site [chemical binding]; other site 675635010906 active site 675635010907 transcription termination factor Rho; Provisional; Region: rho; PRK09376 675635010908 acyl-CoA synthetase; Validated; Region: PRK06164 675635010909 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635010910 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635010911 AMP binding site [chemical binding]; other site 675635010912 active site 675635010913 acyl-activating enzyme (AAE) consensus motif; other site 675635010914 CoA binding site [chemical binding]; other site 675635010915 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 675635010916 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 675635010917 active site 675635010918 FMN binding site [chemical binding]; other site 675635010919 substrate binding site [chemical binding]; other site 675635010920 homotetramer interface [polypeptide binding]; other site 675635010921 catalytic residue [active] 675635010922 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 675635010923 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 675635010924 tetramer interface [polypeptide binding]; other site 675635010925 heme binding pocket [chemical binding]; other site 675635010926 NADPH binding site [chemical binding]; other site 675635010927 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 675635010928 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 675635010929 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635010930 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635010931 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 675635010932 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635010933 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635010934 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635010935 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635010936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635010937 active site 675635010938 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 675635010939 putative active site [active] 675635010940 putative catalytic site [active] 675635010941 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635010942 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635010943 active site 675635010944 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 675635010945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635010946 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 675635010947 Walker A motif; other site 675635010948 ATP binding site [chemical binding]; other site 675635010949 Walker B motif; other site 675635010950 arginine finger; other site 675635010951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635010952 Walker A motif; other site 675635010953 ATP binding site [chemical binding]; other site 675635010954 Walker B motif; other site 675635010955 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 675635010956 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 675635010957 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 675635010958 YCII-related domain; Region: YCII; cl00999 675635010959 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 675635010960 putative hydrophobic ligand binding site [chemical binding]; other site 675635010961 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 675635010962 dinuclear metal binding motif [ion binding]; other site 675635010963 CCC1-related family of proteins; Region: CCC1_like; cl00278 675635010964 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635010965 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635010966 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635010967 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 675635010968 L-lactate permease; Region: Lactate_perm; cl00701 675635010969 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 675635010970 putative FMN binding site [chemical binding]; other site 675635010971 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 675635010972 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 675635010973 dimerization interface [polypeptide binding]; other site 675635010974 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635010975 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635010976 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635010977 NAD(P) binding site [chemical binding]; other site 675635010978 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635010979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635010980 NAD(P) binding site [chemical binding]; other site 675635010981 active site 675635010982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010983 D-galactonate transporter; Region: 2A0114; TIGR00893 675635010984 putative substrate translocation pore; other site 675635010985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635010986 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635010987 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635010988 catalytic site [active] 675635010989 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 675635010990 classical (c) SDRs; Region: SDR_c; cd05233 675635010991 NAD(P) binding site [chemical binding]; other site 675635010992 active site 675635010993 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635010994 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635010995 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635010996 GAF domain; Region: GAF_2; pfam13185 675635010997 GAF domain; Region: GAF; pfam01590 675635010998 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635010999 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635011000 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 675635011001 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635011002 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635011003 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635011004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635011005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635011006 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 675635011007 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635011008 catalytic Zn binding site [ion binding]; other site 675635011009 structural Zn binding site [ion binding]; other site 675635011010 tetramer interface [polypeptide binding]; other site 675635011011 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635011012 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635011013 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 675635011014 DNA binding site [nucleotide binding] 675635011015 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635011016 Predicted ATPase [General function prediction only]; Region: COG3903 675635011017 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635011018 hypothetical protein; Provisional; Region: PRK07588 675635011019 Double zinc ribbon; Region: DZR; pfam12773 675635011020 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 675635011021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635011022 Coenzyme A binding pocket [chemical binding]; other site 675635011023 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 675635011024 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 675635011025 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 675635011026 Ligand Binding Site [chemical binding]; other site 675635011027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635011028 dimer interface [polypeptide binding]; other site 675635011029 phosphorylation site [posttranslational modification] 675635011030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635011031 ATP binding site [chemical binding]; other site 675635011032 Mg2+ binding site [ion binding]; other site 675635011033 G-X-G motif; other site 675635011034 K+-transporting ATPase, c chain; Region: KdpC; cl00944 675635011035 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 675635011036 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635011037 Soluble P-type ATPase [General function prediction only]; Region: COG4087 675635011038 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 675635011039 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 675635011040 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635011041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635011042 DNA-binding site [nucleotide binding]; DNA binding site 675635011043 FCD domain; Region: FCD; pfam07729 675635011044 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635011045 Amidase; Region: Amidase; pfam01425 675635011046 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635011047 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635011048 phenylhydantoinase; Validated; Region: PRK08323 675635011049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635011050 active site 675635011051 Isochorismatase family; Region: Isochorismatase; pfam00857 675635011052 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 675635011053 catalytic triad [active] 675635011054 conserved cis-peptide bond; other site 675635011055 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635011056 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635011057 NAD(P) binding site [chemical binding]; other site 675635011058 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 675635011059 active site 675635011060 catalytic residues [active] 675635011061 metal binding site [ion binding]; metal-binding site 675635011062 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635011063 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635011064 active site 675635011065 catalytic tetrad [active] 675635011066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635011067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635011068 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635011069 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635011070 TM-ABC transporter signature motif; other site 675635011071 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635011072 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 675635011073 Walker A/P-loop; other site 675635011074 ATP binding site [chemical binding]; other site 675635011075 Q-loop/lid; other site 675635011076 ABC transporter signature motif; other site 675635011077 Walker B; other site 675635011078 D-loop; other site 675635011079 H-loop/switch region; other site 675635011080 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 675635011081 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 675635011082 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635011083 ligand binding site [chemical binding]; other site 675635011084 phenylhydantoinase; Validated; Region: PRK08323 675635011085 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635011086 active site 675635011087 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635011088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635011089 DNA-binding site [nucleotide binding]; DNA binding site 675635011090 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 675635011091 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 675635011092 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 675635011093 active site 675635011094 catalytic site [active] 675635011095 tetramer interface [polypeptide binding]; other site 675635011096 Cupin domain; Region: Cupin_2; pfam07883 675635011097 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635011098 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 675635011099 Dehydratase family; Region: ILVD_EDD; cl00340 675635011100 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 675635011101 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 675635011102 TM-ABC transporter signature motif; other site 675635011103 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635011104 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 675635011105 Walker A/P-loop; other site 675635011106 ATP binding site [chemical binding]; other site 675635011107 Q-loop/lid; other site 675635011108 ABC transporter signature motif; other site 675635011109 Walker B; other site 675635011110 D-loop; other site 675635011111 H-loop/switch region; other site 675635011112 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 675635011113 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 675635011114 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 675635011115 ligand binding site [chemical binding]; other site 675635011116 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 675635011117 Isochorismatase family; Region: Isochorismatase; pfam00857 675635011118 catalytic triad [active] 675635011119 conserved cis-peptide bond; other site 675635011120 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635011121 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635011122 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 675635011123 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 675635011124 active site 675635011125 catalytic site [active] 675635011126 tetramer interface [polypeptide binding]; other site 675635011127 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635011128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635011129 DNA-binding site [nucleotide binding]; DNA binding site 675635011130 FCD domain; Region: FCD; pfam07729 675635011131 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635011132 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635011133 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635011134 acetaldehyde dehydrogenase; Validated; Region: PRK08300 675635011135 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 675635011136 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 675635011137 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 675635011138 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 675635011139 active site 675635011140 catalytic residues [active] 675635011141 metal binding site [ion binding]; metal-binding site 675635011142 DmpG-like communication domain; Region: DmpG_comm; pfam07836 675635011143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635011144 S-adenosylmethionine binding site [chemical binding]; other site 675635011145 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635011146 hypothetical protein; Provisional; Region: PRK06446 675635011147 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 675635011148 metal binding site [ion binding]; metal-binding site 675635011149 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 675635011150 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635011151 phosphate binding site [ion binding]; other site 675635011152 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635011153 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635011154 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635011155 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635011156 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 675635011157 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635011158 phosphate binding site [ion binding]; other site 675635011159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635011160 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635011161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635011162 S-adenosylmethionine binding site [chemical binding]; other site 675635011163 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635011164 NMT1/THI5 like; Region: NMT1; pfam09084 675635011165 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 675635011166 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 675635011167 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 675635011168 Walker A/P-loop; other site 675635011169 ATP binding site [chemical binding]; other site 675635011170 Q-loop/lid; other site 675635011171 ABC transporter signature motif; other site 675635011172 Walker B; other site 675635011173 D-loop; other site 675635011174 H-loop/switch region; other site 675635011175 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 675635011176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635011177 dimer interface [polypeptide binding]; other site 675635011178 conserved gate region; other site 675635011179 putative PBP binding loops; other site 675635011180 ABC-ATPase subunit interface; other site 675635011181 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635011182 classical (c) SDRs; Region: SDR_c; cd05233 675635011183 NAD(P) binding site [chemical binding]; other site 675635011184 active site 675635011185 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 675635011186 hypothetical protein; Provisional; Region: PRK06446 675635011187 metal binding site [ion binding]; metal-binding site 675635011188 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635011189 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 675635011190 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635011191 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635011192 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635011193 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635011194 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635011195 Putative cyclase; Region: Cyclase; pfam04199 675635011196 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 675635011197 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 675635011198 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635011199 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635011200 active site 675635011201 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 675635011202 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 675635011203 anti sigma factor interaction site; other site 675635011204 regulatory phosphorylation site [posttranslational modification]; other site 675635011205 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635011206 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635011207 active site 675635011208 metal binding site [ion binding]; metal-binding site 675635011209 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 675635011210 FMN binding site [chemical binding]; other site 675635011211 dimer interface [polypeptide binding]; other site 675635011212 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 675635011213 [2Fe-2S] cluster binding site [ion binding]; other site 675635011214 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 675635011215 [2Fe-2S] cluster binding site [ion binding]; other site 675635011216 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 675635011217 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635011218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635011219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635011220 WHG domain; Region: WHG; pfam13305 675635011221 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635011222 active site 675635011223 nucleotide binding site [chemical binding]; other site 675635011224 HIGH motif; other site 675635011225 KMSKS motif; other site 675635011226 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635011227 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635011228 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635011229 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 675635011230 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 675635011231 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 675635011232 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635011233 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 675635011234 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 675635011235 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635011236 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635011237 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635011238 acyl-activating enzyme (AAE) consensus motif; other site 675635011239 AMP binding site [chemical binding]; other site 675635011240 active site 675635011241 CoA binding site [chemical binding]; other site 675635011242 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635011243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635011244 Predicted transcriptional regulators [Transcription]; Region: COG1733 675635011245 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 675635011246 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635011247 hydrophobic ligand binding site; other site 675635011248 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635011249 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 675635011250 Predicted membrane protein [Function unknown]; Region: COG2323 675635011251 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 675635011252 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 675635011253 molybdopterin cofactor binding site; other site 675635011254 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 675635011255 molybdopterin cofactor binding site; other site 675635011256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011257 active site 675635011258 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 675635011259 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 675635011260 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635011261 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635011262 active site 675635011263 ATP binding site [chemical binding]; other site 675635011264 substrate binding site [chemical binding]; other site 675635011265 activation loop (A-loop); other site 675635011266 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635011267 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635011268 P-loop; other site 675635011269 Magnesium ion binding site [ion binding]; other site 675635011270 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635011271 Magnesium ion binding site [ion binding]; other site 675635011272 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 675635011273 GAF domain; Region: GAF; pfam01590 675635011274 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635011275 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 675635011276 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 675635011277 Gas vesicle protein; Region: Gas_vesicle; cl02954 675635011278 Domain of unknown function (DUF336); Region: DUF336; pfam03928 675635011279 PaaX-like protein; Region: PaaX; pfam07848 675635011280 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 675635011281 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 675635011282 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 675635011283 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635011284 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635011285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635011286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635011287 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 675635011288 acyl-activating enzyme (AAE) consensus motif; other site 675635011289 AMP binding site [chemical binding]; other site 675635011290 active site 675635011291 CoA binding site [chemical binding]; other site 675635011292 Predicted amidohydrolase [General function prediction only]; Region: COG0388 675635011293 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 675635011294 putative active site [active] 675635011295 catalytic triad [active] 675635011296 putative dimer interface [polypeptide binding]; other site 675635011297 hypothetical protein; Provisional; Region: PRK07236 675635011298 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 675635011299 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635011300 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635011301 phosphate binding site [ion binding]; other site 675635011302 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 675635011303 Cupin domain; Region: Cupin_2; pfam07883 675635011304 Cupin domain; Region: Cupin_2; pfam07883 675635011305 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635011306 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 675635011307 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635011308 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 675635011309 active site 675635011310 hypothetical protein; Provisional; Region: PRK07907 675635011311 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 675635011312 active site 675635011313 metal binding site [ion binding]; metal-binding site 675635011314 dimer interface [polypeptide binding]; other site 675635011315 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 675635011316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635011317 DNA binding residues [nucleotide binding] 675635011318 dimerization interface [polypeptide binding]; other site 675635011319 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635011320 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635011321 DNA binding residues [nucleotide binding] 675635011322 dimerization interface [polypeptide binding]; other site 675635011323 Domain of unknown function DUF20; Region: UPF0118; pfam01594 675635011324 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 675635011325 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 675635011326 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 675635011327 RDD family; Region: RDD; pfam06271 675635011328 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 675635011329 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 675635011330 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 675635011331 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635011332 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 675635011333 Soluble P-type ATPase [General function prediction only]; Region: COG4087 675635011334 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 675635011335 high affinity sulphate transporter 1; Region: sulP; TIGR00815 675635011336 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 675635011337 Sulfate transporter family; Region: Sulfate_transp; pfam00916 675635011338 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 675635011339 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635011340 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635011341 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635011342 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 675635011343 Ion channel; Region: Ion_trans_2; pfam07885 675635011344 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 675635011345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635011346 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635011347 DNA binding residues [nucleotide binding] 675635011348 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635011349 Zn2+ binding site [ion binding]; other site 675635011350 Mg2+ binding site [ion binding]; other site 675635011351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 675635011352 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 675635011353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635011354 putative substrate translocation pore; other site 675635011355 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 675635011356 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 675635011357 dimer interface [polypeptide binding]; other site 675635011358 NADP binding site [chemical binding]; other site 675635011359 catalytic residues [active] 675635011360 4Fe-4S binding domain; Region: Fer4; cl02805 675635011361 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 675635011362 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 675635011363 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635011364 active site 675635011365 metal binding site [ion binding]; metal-binding site 675635011366 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635011367 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635011368 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 675635011369 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635011370 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 675635011371 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 675635011372 [2Fe-2S] cluster binding site [ion binding]; other site 675635011373 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635011374 hydrophobic ligand binding site; other site 675635011375 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 675635011376 inter-subunit interface; other site 675635011377 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 675635011378 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635011379 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635011380 active site 1 [active] 675635011381 dimer interface [polypeptide binding]; other site 675635011382 hexamer interface [polypeptide binding]; other site 675635011383 active site 2 [active] 675635011384 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635011385 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 675635011386 Protein of unknown function (DUF421); Region: DUF421; pfam04239 675635011387 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635011388 Putative serine esterase (DUF676); Region: DUF676; pfam05057 675635011389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635011390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635011391 Hedgehog amino-terminal signalling domain; Region: HH_signal; pfam01085 675635011392 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 675635011393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635011394 putative substrate translocation pore; other site 675635011395 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 675635011396 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 675635011397 [4Fe-4S] binding site [ion binding]; other site 675635011398 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635011399 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635011400 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635011401 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 675635011402 molybdopterin cofactor binding site; other site 675635011403 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 675635011404 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 675635011405 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 675635011406 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635011407 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 675635011408 Phosphoesterase family; Region: Phosphoesterase; pfam04185 675635011409 Phosphoesterase family; Region: Phosphoesterase; pfam04185 675635011410 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 675635011411 haloalkane dehalogenase; Provisional; Region: PRK03592 675635011412 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 675635011413 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 675635011414 metal binding site [ion binding]; metal-binding site 675635011415 substrate binding pocket [chemical binding]; other site 675635011416 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 675635011417 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 675635011418 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635011419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635011420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635011421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 675635011422 AAA ATPase domain; Region: AAA_16; pfam13191 675635011423 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635011424 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635011425 DNA binding residues [nucleotide binding] 675635011426 dimerization interface [polypeptide binding]; other site 675635011427 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 675635011428 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 675635011429 AAA ATPase domain; Region: AAA_16; pfam13191 675635011430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635011431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635011432 DNA binding residues [nucleotide binding] 675635011433 dimerization interface [polypeptide binding]; other site 675635011434 short chain dehydrogenase; Provisional; Region: PRK07041 675635011435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011436 NAD(P) binding site [chemical binding]; other site 675635011437 active site 675635011438 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 675635011439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635011440 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635011441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 675635011442 MOSC domain; Region: MOSC; pfam03473 675635011443 3-alpha domain; Region: 3-alpha; pfam03475 675635011444 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 675635011445 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 675635011446 FAD binding pocket [chemical binding]; other site 675635011447 FAD binding motif [chemical binding]; other site 675635011448 phosphate binding motif [ion binding]; other site 675635011449 beta-alpha-beta structure motif; other site 675635011450 NAD binding pocket [chemical binding]; other site 675635011451 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635011452 catalytic loop [active] 675635011453 iron binding site [ion binding]; other site 675635011454 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635011455 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 675635011456 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635011457 Zn2+ binding site [ion binding]; other site 675635011458 Mg2+ binding site [ion binding]; other site 675635011459 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635011460 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635011461 DNA binding residues [nucleotide binding] 675635011462 dimerization interface [polypeptide binding]; other site 675635011463 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 675635011464 hypothetical protein; Provisional; Region: PRK06153 675635011465 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 675635011466 ATP binding site [chemical binding]; other site 675635011467 substrate interface [chemical binding]; other site 675635011468 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635011469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635011470 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635011471 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 675635011472 active site 675635011473 Mn binding site [ion binding]; other site 675635011474 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 675635011475 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 675635011476 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 675635011477 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 675635011478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635011479 putative DNA binding site [nucleotide binding]; other site 675635011480 putative Zn2+ binding site [ion binding]; other site 675635011481 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 675635011482 putative hydrophobic ligand binding site [chemical binding]; other site 675635011483 CLM binding site; other site 675635011484 L1 loop; other site 675635011485 DNA binding site [nucleotide binding] 675635011486 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635011487 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 675635011488 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 675635011489 active site 675635011490 substrate binding site [chemical binding]; other site 675635011491 ATP binding site [chemical binding]; other site 675635011492 Phosphotransferase enzyme family; Region: APH; pfam01636 675635011493 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 675635011494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635011495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635011496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635011497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635011498 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635011499 active site residue [active] 675635011500 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635011501 active site residue [active] 675635011502 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635011503 dimerization interface [polypeptide binding]; other site 675635011504 putative DNA binding site [nucleotide binding]; other site 675635011505 putative Zn2+ binding site [ion binding]; other site 675635011506 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635011507 active site residue [active] 675635011508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635011509 H+ Antiporter protein; Region: 2A0121; TIGR00900 675635011510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635011511 putative substrate translocation pore; other site 675635011512 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635011513 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635011514 metal-binding site [ion binding] 675635011515 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635011516 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 675635011517 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 675635011518 catalytic residues [active] 675635011519 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 675635011520 putative active site [active] 675635011521 redox center [active] 675635011522 Thioredoxin; Region: Thioredoxin_4; pfam13462 675635011523 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 675635011524 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 675635011525 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 675635011526 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635011527 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 675635011528 CopC domain; Region: CopC; pfam04234 675635011529 Lsr2; Region: Lsr2; pfam11774 675635011530 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635011531 Methyltransferase domain; Region: Methyltransf_11; pfam08241 675635011532 manganese transport protein MntH; Reviewed; Region: PRK00701 675635011533 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 675635011534 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 675635011535 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635011536 Soluble P-type ATPase [General function prediction only]; Region: COG4087 675635011537 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635011538 dimerization interface [polypeptide binding]; other site 675635011539 putative DNA binding site [nucleotide binding]; other site 675635011540 putative Zn2+ binding site [ion binding]; other site 675635011541 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 675635011542 TrwC relaxase; Region: TrwC; pfam08751 675635011543 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 675635011544 AAA domain; Region: AAA_30; pfam13604 675635011545 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 675635011546 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 675635011547 Walker A motif; other site 675635011548 ATP binding site [chemical binding]; other site 675635011549 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 675635011550 Walker B motif; other site 675635011551 Helix-turn-helix domain; Region: HTH_17; pfam12728 675635011552 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 675635011553 dimer interface [polypeptide binding]; other site 675635011554 ADP-ribose binding site [chemical binding]; other site 675635011555 active site 675635011556 nudix motif; other site 675635011557 metal binding site [ion binding]; metal-binding site 675635011558 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635011559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635011560 DNA-binding site [nucleotide binding]; DNA binding site 675635011561 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635011562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635011563 DNA-binding site [nucleotide binding]; DNA binding site 675635011564 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635011565 active site 675635011566 DNA binding site [nucleotide binding] 675635011567 Int/Topo IB signature motif; other site 675635011568 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635011569 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 675635011570 Protein of unknown function (DUF419); Region: DUF419; cl15265 675635011571 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 675635011572 putative hydrophobic ligand binding site [chemical binding]; other site 675635011573 protein interface [polypeptide binding]; other site 675635011574 gate; other site 675635011575 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 675635011576 hypothetical protein; Provisional; Region: PRK02399 675635011577 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 675635011578 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 675635011579 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 675635011580 nucleotide binding site [chemical binding]; other site 675635011581 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 675635011582 putative active site [active] 675635011583 putative metal binding site [ion binding]; other site 675635011584 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 675635011585 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 675635011586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635011587 Coenzyme A binding pocket [chemical binding]; other site 675635011588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 675635011589 tetracycline repressor protein TetR; Provisional; Region: PRK13756 675635011590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635011591 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 675635011592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635011593 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635011594 putative substrate translocation pore; other site 675635011595 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635011596 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 675635011597 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 675635011598 B12 binding site [chemical binding]; other site 675635011599 cobalt ligand [ion binding]; other site 675635011600 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 675635011601 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 675635011602 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 675635011603 MarR family; Region: MarR_2; pfam12802 675635011604 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 675635011605 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 675635011606 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 675635011607 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 675635011608 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 675635011609 intersubunit interface [polypeptide binding]; other site 675635011610 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 675635011611 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635011612 substrate binding site [chemical binding]; other site 675635011613 oxyanion hole (OAH) forming residues; other site 675635011614 trimer interface [polypeptide binding]; other site 675635011615 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 675635011616 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635011617 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635011618 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635011619 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 675635011620 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635011621 catalytic residue [active] 675635011622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635011623 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 675635011624 FAD binding domain; Region: FAD_binding_4; pfam01565 675635011625 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 675635011626 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 675635011627 nudix motif; other site 675635011628 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 675635011629 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635011630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635011631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635011632 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 675635011633 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635011634 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 675635011635 [2Fe-2S] cluster binding site [ion binding]; other site 675635011636 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 675635011637 putative alpha subunit interface [polypeptide binding]; other site 675635011638 putative active site [active] 675635011639 putative substrate binding site [chemical binding]; other site 675635011640 Fe binding site [ion binding]; other site 675635011641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635011642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635011643 S-adenosylmethionine binding site [chemical binding]; other site 675635011644 Cupin domain; Region: Cupin_2; cl17218 675635011645 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635011646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635011647 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635011648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635011649 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635011650 Cytochrome P450; Region: p450; cl12078 675635011651 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635011652 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635011653 Cytochrome P450; Region: p450; cl12078 675635011654 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635011655 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 675635011656 active site 675635011657 catalytic tetrad [active] 675635011658 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635011659 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635011660 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635011661 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 675635011662 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 675635011663 putative hydrophobic ligand binding site [chemical binding]; other site 675635011664 FAD binding domain; Region: FAD_binding_3; pfam01494 675635011665 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635011666 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635011667 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635011668 FAD binding domain; Region: FAD_binding_3; pfam01494 675635011669 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 675635011670 active site 675635011671 NAD binding site [chemical binding]; other site 675635011672 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635011673 metal binding site [ion binding]; metal-binding site 675635011674 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 675635011675 active site 675635011676 NAD binding site [chemical binding]; other site 675635011677 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635011678 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635011679 active site 675635011680 metal binding site [ion binding]; metal-binding site 675635011681 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635011682 MarR family; Region: MarR; pfam01047 675635011683 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635011684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635011685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635011686 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 675635011687 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 675635011688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635011689 S-adenosylmethionine binding site [chemical binding]; other site 675635011690 DNA primase; Validated; Region: dnaG; PRK05667 675635011691 CHC2 zinc finger; Region: zf-CHC2; pfam01807 675635011692 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 675635011693 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 675635011694 active site 675635011695 metal binding site [ion binding]; metal-binding site 675635011696 interdomain interaction site; other site 675635011697 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 675635011698 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 675635011699 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635011700 active site 675635011701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635011702 NADH(P)-binding; Region: NAD_binding_10; pfam13460 675635011703 NAD(P) binding site [chemical binding]; other site 675635011704 active site 675635011705 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 675635011706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635011707 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635011708 DNA binding residues [nucleotide binding] 675635011709 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635011710 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635011711 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 675635011712 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635011713 Zn2+ binding site [ion binding]; other site 675635011714 Mg2+ binding site [ion binding]; other site 675635011715 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 675635011716 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 675635011717 putative active site [active] 675635011718 XdhC Rossmann domain; Region: XdhC_C; pfam13478 675635011719 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635011720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635011721 active site 675635011722 phosphorylation site [posttranslational modification] 675635011723 intermolecular recognition site; other site 675635011724 dimerization interface [polypeptide binding]; other site 675635011725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635011726 DNA binding residues [nucleotide binding] 675635011727 dimerization interface [polypeptide binding]; other site 675635011728 Histidine kinase; Region: HisKA_3; pfam07730 675635011729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635011730 ATP binding site [chemical binding]; other site 675635011731 Mg2+ binding site [ion binding]; other site 675635011732 G-X-G motif; other site 675635011733 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 675635011734 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 675635011735 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 675635011736 Walker A/P-loop; other site 675635011737 ATP binding site [chemical binding]; other site 675635011738 Q-loop/lid; other site 675635011739 ABC transporter signature motif; other site 675635011740 Walker B; other site 675635011741 D-loop; other site 675635011742 H-loop/switch region; other site 675635011743 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 675635011744 Domain of unknown function DUF21; Region: DUF21; pfam01595 675635011745 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 675635011746 Transporter associated domain; Region: CorC_HlyC; pfam03471 675635011747 Domain of unknown function DUF21; Region: DUF21; pfam01595 675635011748 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 675635011749 glycyl-tRNA synthetase; Provisional; Region: PRK04173 675635011750 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 675635011751 motif 1; other site 675635011752 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 675635011753 dimer interface [polypeptide binding]; other site 675635011754 active site 675635011755 motif 2; other site 675635011756 motif 3; other site 675635011757 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 675635011758 anticodon binding site; other site 675635011759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635011760 dimerization interface [polypeptide binding]; other site 675635011761 putative DNA binding site [nucleotide binding]; other site 675635011762 putative Zn2+ binding site [ion binding]; other site 675635011763 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 675635011764 putative hydrophobic ligand binding site [chemical binding]; other site 675635011765 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 675635011766 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635011767 putative DNA binding site [nucleotide binding]; other site 675635011768 putative Zn2+ binding site [ion binding]; other site 675635011769 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 675635011770 metal binding site 2 [ion binding]; metal-binding site 675635011771 putative DNA binding helix; other site 675635011772 metal binding site 1 [ion binding]; metal-binding site 675635011773 dimer interface [polypeptide binding]; other site 675635011774 structural Zn2+ binding site [ion binding]; other site 675635011775 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 675635011776 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 675635011777 catalytic residue [active] 675635011778 putative FPP diphosphate binding site; other site 675635011779 putative FPP binding hydrophobic cleft; other site 675635011780 dimer interface [polypeptide binding]; other site 675635011781 putative IPP diphosphate binding site; other site 675635011782 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 675635011783 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 675635011784 Recombination protein O N terminal; Region: RecO_N; pfam11967 675635011785 Recombination protein O C terminal; Region: RecO_C; pfam02565 675635011786 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 675635011787 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 675635011788 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 675635011789 GTPase Era; Reviewed; Region: era; PRK00089 675635011790 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 675635011791 G1 box; other site 675635011792 GTP/Mg2+ binding site [chemical binding]; other site 675635011793 Switch I region; other site 675635011794 G2 box; other site 675635011795 Switch II region; other site 675635011796 G3 box; other site 675635011797 G4 box; other site 675635011798 G5 box; other site 675635011799 KH domain; Region: KH_2; pfam07650 675635011800 hydroxyglutarate oxidase; Provisional; Region: PRK11728 675635011801 Predicted dehydrogenase [General function prediction only]; Region: COG0579 675635011802 Domain of unknown function DUF21; Region: DUF21; pfam01595 675635011803 FOG: CBS domain [General function prediction only]; Region: COG0517 675635011804 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 675635011805 Transporter associated domain; Region: CorC_HlyC; smart01091 675635011806 metal-binding heat shock protein; Provisional; Region: PRK00016 675635011807 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 675635011808 PhoH-like protein; Region: PhoH; pfam02562 675635011809 Isochorismatase family; Region: Isochorismatase; pfam00857 675635011810 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 675635011811 catalytic triad [active] 675635011812 dimer interface [polypeptide binding]; other site 675635011813 conserved cis-peptide bond; other site 675635011814 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 675635011815 PYR/PP interface [polypeptide binding]; other site 675635011816 dimer interface [polypeptide binding]; other site 675635011817 TPP binding site [chemical binding]; other site 675635011818 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 675635011819 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 675635011820 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 675635011821 TPP-binding site [chemical binding]; other site 675635011822 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 675635011823 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635011824 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 675635011825 chaperone protein DnaJ; Provisional; Region: PRK14278 675635011826 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 675635011827 HSP70 interaction site [polypeptide binding]; other site 675635011828 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 675635011829 Zn binding sites [ion binding]; other site 675635011830 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 675635011831 dimer interface [polypeptide binding]; other site 675635011832 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 675635011833 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 675635011834 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 675635011835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635011836 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 675635011837 Walker A/P-loop; other site 675635011838 ATP binding site [chemical binding]; other site 675635011839 Q-loop/lid; other site 675635011840 ABC transporter signature motif; other site 675635011841 Walker B; other site 675635011842 D-loop; other site 675635011843 H-loop/switch region; other site 675635011844 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 675635011845 coproporphyrinogen III oxidase; Validated; Region: PRK05628 675635011846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635011847 FeS/SAM binding site; other site 675635011848 HlyD family secretion protein; Region: HlyD_3; pfam13437 675635011849 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 675635011850 FtsX-like permease family; Region: FtsX; pfam02687 675635011851 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635011852 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 675635011853 Walker A/P-loop; other site 675635011854 ATP binding site [chemical binding]; other site 675635011855 Q-loop/lid; other site 675635011856 ABC transporter signature motif; other site 675635011857 Walker B; other site 675635011858 D-loop; other site 675635011859 H-loop/switch region; other site 675635011860 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 675635011861 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 675635011862 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 675635011863 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 675635011864 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 675635011865 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 675635011866 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 675635011867 Active Sites [active] 675635011868 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 675635011869 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 675635011870 Active Sites [active] 675635011871 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 675635011872 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 675635011873 CysD dimerization site [polypeptide binding]; other site 675635011874 G1 box; other site 675635011875 putative GEF interaction site [polypeptide binding]; other site 675635011876 GTP/Mg2+ binding site [chemical binding]; other site 675635011877 Switch I region; other site 675635011878 G2 box; other site 675635011879 G3 box; other site 675635011880 Switch II region; other site 675635011881 G4 box; other site 675635011882 G5 box; other site 675635011883 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 675635011884 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 675635011885 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 675635011886 NMT1-like family; Region: NMT1_2; pfam13379 675635011887 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 675635011888 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 675635011889 Walker A/P-loop; other site 675635011890 ATP binding site [chemical binding]; other site 675635011891 Q-loop/lid; other site 675635011892 ABC transporter signature motif; other site 675635011893 Walker B; other site 675635011894 D-loop; other site 675635011895 H-loop/switch region; other site 675635011896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635011897 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 675635011898 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 675635011899 putative active site [active] 675635011900 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 675635011901 putative active site [active] 675635011902 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635011903 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 675635011904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635011905 Walker A/P-loop; other site 675635011906 ATP binding site [chemical binding]; other site 675635011907 Q-loop/lid; other site 675635011908 ABC transporter signature motif; other site 675635011909 Walker B; other site 675635011910 D-loop; other site 675635011911 H-loop/switch region; other site 675635011912 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 675635011913 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635011914 active site 675635011915 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 675635011916 dimer interface [polypeptide binding]; other site 675635011917 non-prolyl cis peptide bond; other site 675635011918 insertion regions; other site 675635011919 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635011920 CoenzymeA binding site [chemical binding]; other site 675635011921 subunit interaction site [polypeptide binding]; other site 675635011922 PHB binding site; other site 675635011923 enoyl-CoA hydratase; Provisional; Region: PRK07827 675635011924 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635011925 substrate binding site [chemical binding]; other site 675635011926 oxyanion hole (OAH) forming residues; other site 675635011927 trimer interface [polypeptide binding]; other site 675635011928 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 675635011929 TIGR03086 family protein; Region: TIGR03086 675635011930 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635011931 NAD-dependent deacetylase; Provisional; Region: PRK05333 675635011932 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 675635011933 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 675635011934 RNAase interaction site [polypeptide binding]; other site 675635011935 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 675635011936 active site 675635011937 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635011938 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635011939 NAD(P) binding site [chemical binding]; other site 675635011940 GTP-binding protein LepA; Provisional; Region: PRK05433 675635011941 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 675635011942 G1 box; other site 675635011943 putative GEF interaction site [polypeptide binding]; other site 675635011944 GTP/Mg2+ binding site [chemical binding]; other site 675635011945 Switch I region; other site 675635011946 G2 box; other site 675635011947 G3 box; other site 675635011948 Switch II region; other site 675635011949 G4 box; other site 675635011950 G5 box; other site 675635011951 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 675635011952 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 675635011953 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 675635011954 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 675635011955 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 675635011956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 675635011957 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635011958 NlpC/P60 family; Region: NLPC_P60; pfam00877 675635011959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635011960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 675635011961 active site 675635011962 phosphorylation site [posttranslational modification] 675635011963 intermolecular recognition site; other site 675635011964 dimerization interface [polypeptide binding]; other site 675635011965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635011966 DNA binding residues [nucleotide binding] 675635011967 dimerization interface [polypeptide binding]; other site 675635011968 Putative sensor; Region: Sensor; pfam13796 675635011969 Histidine kinase; Region: HisKA_3; pfam07730 675635011970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635011971 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 675635011972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635011973 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635011974 substrate binding site [chemical binding]; other site 675635011975 oxyanion hole (OAH) forming residues; other site 675635011976 trimer interface [polypeptide binding]; other site 675635011977 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 675635011978 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 675635011979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635011980 S-adenosylmethionine binding site [chemical binding]; other site 675635011981 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 675635011982 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635011983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635011984 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 675635011985 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635011986 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635011987 active site 675635011988 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 675635011989 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 675635011990 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 675635011991 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 675635011992 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 675635011993 dimer interface [polypeptide binding]; other site 675635011994 active site 675635011995 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 675635011996 Ligand Binding Site [chemical binding]; other site 675635011997 Molecular Tunnel; other site 675635011998 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635011999 Fatty acid desaturase; Region: FA_desaturase; pfam00487 675635012000 Di-iron ligands [ion binding]; other site 675635012001 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635012002 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 675635012003 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 675635012004 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635012005 FAD binding domain; Region: FAD_binding_4; pfam01565 675635012006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635012007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635012008 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 675635012009 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 675635012010 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 675635012011 substrate binding site [chemical binding]; other site 675635012012 ATP binding site [chemical binding]; other site 675635012013 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 675635012014 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 675635012015 Glycerate kinase family; Region: Gly_kinase; cl00841 675635012016 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 675635012017 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 675635012018 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 675635012019 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 675635012020 active site pocket [active] 675635012021 putative cataytic base [active] 675635012022 cobalamin synthase; Reviewed; Region: cobS; PRK00235 675635012023 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 675635012024 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 675635012025 homodimer interface [polypeptide binding]; other site 675635012026 substrate-cofactor binding pocket; other site 675635012027 catalytic residue [active] 675635012028 amino acid transporter; Region: 2A0306; TIGR00909 675635012029 multifunctional aminopeptidase A; Provisional; Region: PRK00913 675635012030 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 675635012031 interface (dimer of trimers) [polypeptide binding]; other site 675635012032 Substrate-binding/catalytic site; other site 675635012033 Zn-binding sites [ion binding]; other site 675635012034 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 675635012035 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635012036 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635012037 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635012038 E3 interaction surface; other site 675635012039 lipoyl attachment site [posttranslational modification]; other site 675635012040 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635012041 E3 interaction surface; other site 675635012042 lipoyl attachment site [posttranslational modification]; other site 675635012043 e3 binding domain; Region: E3_binding; pfam02817 675635012044 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 675635012045 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 675635012046 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 675635012047 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 675635012048 putative NAD(P) binding site [chemical binding]; other site 675635012049 putative active site [active] 675635012050 lipoate-protein ligase B; Provisional; Region: PRK14345 675635012051 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 675635012052 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635012053 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635012054 lipoyl synthase; Provisional; Region: PRK05481 675635012055 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635012056 FeS/SAM binding site; other site 675635012057 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 675635012058 RDD family; Region: RDD; pfam06271 675635012059 glutamine synthetase, type I; Region: GlnA; TIGR00653 675635012060 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 675635012061 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 675635012062 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 675635012063 tetracycline repressor protein TetR; Provisional; Region: PRK13756 675635012064 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 675635012065 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 675635012066 DNA-binding site [nucleotide binding]; DNA binding site 675635012067 RNA-binding motif; other site 675635012068 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635012069 Fatty acid desaturase; Region: FA_desaturase; pfam00487 675635012070 Di-iron ligands [ion binding]; other site 675635012071 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635012072 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 675635012073 Uncharacterized conserved protein [Function unknown]; Region: COG0397 675635012074 hypothetical protein; Validated; Region: PRK00029 675635012075 pyruvate phosphate dikinase; Provisional; Region: PRK09279 675635012076 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 675635012077 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 675635012078 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 675635012079 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 675635012080 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635012081 Domain of unknown function (DUF385); Region: DUF385; pfam04075 675635012082 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 675635012083 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 675635012084 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635012085 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 675635012086 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635012087 catalytic loop [active] 675635012088 iron binding site [ion binding]; other site 675635012089 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 675635012090 L-aspartate oxidase; Provisional; Region: PRK06175 675635012091 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 675635012092 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 675635012093 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 675635012094 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 675635012095 L-aspartate oxidase; Provisional; Region: PRK06175 675635012096 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 675635012097 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 675635012098 putative Iron-sulfur protein interface [polypeptide binding]; other site 675635012099 proximal heme binding site [chemical binding]; other site 675635012100 distal heme binding site [chemical binding]; other site 675635012101 putative dimer interface [polypeptide binding]; other site 675635012102 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 675635012103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635012104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 675635012105 dimerization interface [polypeptide binding]; other site 675635012106 recombination regulator RecX; Reviewed; Region: recX; PRK00117 675635012107 recombinase A; Provisional; Region: recA; PRK09354 675635012108 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 675635012109 hexamer interface [polypeptide binding]; other site 675635012110 Walker A motif; other site 675635012111 ATP binding site [chemical binding]; other site 675635012112 Walker B motif; other site 675635012113 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 675635012114 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635012115 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635012116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635012117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635012118 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 675635012119 EamA-like transporter family; Region: EamA; pfam00892 675635012120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635012121 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 675635012122 ATP binding site [chemical binding]; other site 675635012123 putative Mg++ binding site [ion binding]; other site 675635012124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635012125 nucleotide binding region [chemical binding]; other site 675635012126 ATP-binding site [chemical binding]; other site 675635012127 DEAD/H associated; Region: DEAD_assoc; pfam08494 675635012128 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 675635012129 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 675635012130 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635012131 acyl-activating enzyme (AAE) consensus motif; other site 675635012132 AMP binding site [chemical binding]; other site 675635012133 active site 675635012134 CoA binding site [chemical binding]; other site 675635012135 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 675635012136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635012137 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 675635012138 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 675635012139 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635012140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635012141 active site 675635012142 phosphorylation site [posttranslational modification] 675635012143 intermolecular recognition site; other site 675635012144 dimerization interface [polypeptide binding]; other site 675635012145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635012146 DNA binding residues [nucleotide binding] 675635012147 dimerization interface [polypeptide binding]; other site 675635012148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635012149 Histidine kinase; Region: HisKA_3; pfam07730 675635012150 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 675635012151 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 675635012152 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635012153 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 675635012154 Walker A/P-loop; other site 675635012155 ATP binding site [chemical binding]; other site 675635012156 Q-loop/lid; other site 675635012157 ABC transporter signature motif; other site 675635012158 Walker B; other site 675635012159 D-loop; other site 675635012160 H-loop/switch region; other site 675635012161 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 675635012162 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 675635012163 putative DNA binding site [nucleotide binding]; other site 675635012164 catalytic residue [active] 675635012165 putative H2TH interface [polypeptide binding]; other site 675635012166 putative catalytic residues [active] 675635012167 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 675635012168 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 675635012169 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 675635012170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 675635012171 sequence-specific DNA binding site [nucleotide binding]; other site 675635012172 salt bridge; other site 675635012173 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 675635012174 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 675635012175 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 675635012176 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 675635012177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635012178 FeS/SAM binding site; other site 675635012179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635012180 Coenzyme A binding pocket [chemical binding]; other site 675635012181 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635012182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635012183 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 675635012184 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635012185 YceI-like domain; Region: YceI; pfam04264 675635012186 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 675635012187 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635012188 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 675635012189 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 675635012190 Ferredoxin [Energy production and conversion]; Region: COG1146 675635012191 4Fe-4S binding domain; Region: Fer4; pfam00037 675635012192 Helix-turn-helix domain; Region: HTH_20; pfam12840 675635012193 Predicted transcriptional regulator [Transcription]; Region: COG2345 675635012194 putative DNA binding site [nucleotide binding]; other site 675635012195 putative Zn2+ binding site [ion binding]; other site 675635012196 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635012197 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635012198 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635012199 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 675635012200 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 675635012201 tetramer interface [polypeptide binding]; other site 675635012202 active site 675635012203 Mg2+/Mn2+ binding site [ion binding]; other site 675635012204 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635012205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635012206 DNA-binding site [nucleotide binding]; DNA binding site 675635012207 FCD domain; Region: FCD; pfam07729 675635012208 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635012209 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635012210 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635012211 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635012212 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 675635012213 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 675635012214 catalytic triad [active] 675635012215 conserved cis-peptide bond; other site 675635012216 DNA topoisomerase III; Provisional; Region: PRK14724 675635012217 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635012218 Amidase; Region: Amidase; pfam01425 675635012219 putative amidase; Provisional; Region: PRK06169 675635012220 Amidase; Region: Amidase; cl11426 675635012221 Amidase; Region: Amidase; cl11426 675635012222 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635012223 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635012224 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 675635012225 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 675635012226 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635012227 Walker A/P-loop; other site 675635012228 ATP binding site [chemical binding]; other site 675635012229 Q-loop/lid; other site 675635012230 ABC transporter signature motif; other site 675635012231 Walker B; other site 675635012232 D-loop; other site 675635012233 H-loop/switch region; other site 675635012234 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 675635012235 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635012236 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635012237 Walker A/P-loop; other site 675635012238 ATP binding site [chemical binding]; other site 675635012239 Q-loop/lid; other site 675635012240 ABC transporter signature motif; other site 675635012241 Walker B; other site 675635012242 D-loop; other site 675635012243 H-loop/switch region; other site 675635012244 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635012245 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635012246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635012247 dimer interface [polypeptide binding]; other site 675635012248 conserved gate region; other site 675635012249 putative PBP binding loops; other site 675635012250 ABC-ATPase subunit interface; other site 675635012251 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635012252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635012253 putative PBP binding loops; other site 675635012254 dimer interface [polypeptide binding]; other site 675635012255 ABC-ATPase subunit interface; other site 675635012256 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635012257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635012258 DNA-binding site [nucleotide binding]; DNA binding site 675635012259 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 675635012260 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 675635012261 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 675635012262 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 675635012263 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 675635012264 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 675635012265 dimer interface [polypeptide binding]; other site 675635012266 active site 675635012267 catalytic residue [active] 675635012268 TIGR03085 family protein; Region: TIGR03085 675635012269 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 675635012270 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 675635012271 HicB family; Region: HicB; pfam05534 675635012272 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 675635012273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 675635012274 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 675635012275 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 675635012276 EamA-like transporter family; Region: EamA; pfam00892 675635012277 EamA-like transporter family; Region: EamA; pfam00892 675635012278 dihydrodipicolinate reductase; Provisional; Region: PRK00048 675635012279 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 675635012280 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 675635012281 Protein of unknown function (DUF456); Region: DUF456; pfam04306 675635012282 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 675635012283 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 675635012284 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 675635012285 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 675635012286 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 675635012287 oligomer interface [polypeptide binding]; other site 675635012288 RNA binding site [nucleotide binding]; other site 675635012289 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 675635012290 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 675635012291 RNase E interface [polypeptide binding]; other site 675635012292 trimer interface [polypeptide binding]; other site 675635012293 active site 675635012294 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 675635012295 putative nucleic acid binding region [nucleotide binding]; other site 675635012296 G-X-X-G motif; other site 675635012297 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 675635012298 RNA binding site [nucleotide binding]; other site 675635012299 domain interface; other site 675635012300 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 675635012301 16S/18S rRNA binding site [nucleotide binding]; other site 675635012302 S13e-L30e interaction site [polypeptide binding]; other site 675635012303 25S rRNA binding site [nucleotide binding]; other site 675635012304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 675635012305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635012306 non-specific DNA binding site [nucleotide binding]; other site 675635012307 salt bridge; other site 675635012308 sequence-specific DNA binding site [nucleotide binding]; other site 675635012309 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 675635012310 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 675635012311 active site 675635012312 Riboflavin kinase; Region: Flavokinase; smart00904 675635012313 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 675635012314 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 675635012315 RNA binding site [nucleotide binding]; other site 675635012316 active site 675635012317 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 675635012318 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 675635012319 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 675635012320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635012321 S-adenosylmethionine binding site [chemical binding]; other site 675635012322 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 675635012323 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 675635012324 Protein of unknown function (DUF503); Region: DUF503; pfam04456 675635012325 translation initiation factor IF-2; Region: IF-2; TIGR00487 675635012326 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 675635012327 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 675635012328 G1 box; other site 675635012329 putative GEF interaction site [polypeptide binding]; other site 675635012330 GTP/Mg2+ binding site [chemical binding]; other site 675635012331 Switch I region; other site 675635012332 G2 box; other site 675635012333 G3 box; other site 675635012334 Switch II region; other site 675635012335 G4 box; other site 675635012336 G5 box; other site 675635012337 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 675635012338 Translation-initiation factor 2; Region: IF-2; pfam11987 675635012339 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 675635012340 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 675635012341 NusA N-terminal domain; Region: NusA_N; pfam08529 675635012342 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 675635012343 RNA binding site [nucleotide binding]; other site 675635012344 homodimer interface [polypeptide binding]; other site 675635012345 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 675635012346 G-X-X-G motif; other site 675635012347 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 675635012348 G-X-X-G motif; other site 675635012349 ribosome maturation protein RimP; Reviewed; Region: PRK00092 675635012350 Sm and related proteins; Region: Sm_like; cl00259 675635012351 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 675635012352 putative oligomer interface [polypeptide binding]; other site 675635012353 putative RNA binding site [nucleotide binding]; other site 675635012354 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 675635012355 dinuclear metal binding motif [ion binding]; other site 675635012356 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 675635012357 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635012358 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 675635012359 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 675635012360 putative active site [active] 675635012361 prolyl-tRNA synthetase; Provisional; Region: PRK09194 675635012362 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 675635012363 motif 1; other site 675635012364 dimer interface [polypeptide binding]; other site 675635012365 active site 675635012366 motif 2; other site 675635012367 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 675635012368 putative deacylase active site [active] 675635012369 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 675635012370 active site 675635012371 motif 3; other site 675635012372 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 675635012373 anticodon binding site; other site 675635012374 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 675635012375 DNA-binding site [nucleotide binding]; DNA binding site 675635012376 RNA-binding motif; other site 675635012377 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 675635012378 DNA-binding site [nucleotide binding]; DNA binding site 675635012379 RNA-binding motif; other site 675635012380 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 675635012381 DNA-binding site [nucleotide binding]; DNA binding site 675635012382 RNA-binding motif; other site 675635012383 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 675635012384 DNA-binding site [nucleotide binding]; DNA binding site 675635012385 RNA-binding motif; other site 675635012386 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635012387 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 675635012388 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 675635012389 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 675635012390 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 675635012391 homodimer interface [polypeptide binding]; other site 675635012392 substrate-cofactor binding pocket; other site 675635012393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635012394 catalytic residue [active] 675635012395 hypothetical protein; Validated; Region: PRK02101 675635012396 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 675635012397 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 675635012398 ATP binding site [chemical binding]; other site 675635012399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 675635012400 DEAD-like helicases superfamily; Region: DEXDc; smart00487 675635012401 ATP binding site [chemical binding]; other site 675635012402 putative Mg++ binding site [ion binding]; other site 675635012403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635012404 nucleotide binding region [chemical binding]; other site 675635012405 ATP-binding site [chemical binding]; other site 675635012406 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 675635012407 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635012408 active site 675635012409 HIGH motif; other site 675635012410 nucleotide binding site [chemical binding]; other site 675635012411 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635012412 active site 675635012413 KMSKS motif; other site 675635012414 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 675635012415 tRNA binding surface [nucleotide binding]; other site 675635012416 anticodon binding site; other site 675635012417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 675635012418 mycothione reductase; Reviewed; Region: PRK07846 675635012419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635012420 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635012421 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 675635012422 Fatty acid desaturase; Region: FA_desaturase; pfam00487 675635012423 Di-iron ligands [ion binding]; other site 675635012424 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 675635012425 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635012426 putative acyl-acceptor binding pocket; other site 675635012427 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635012428 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 675635012429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 675635012430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635012431 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 675635012432 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 675635012433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635012434 S-adenosylmethionine binding site [chemical binding]; other site 675635012435 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 675635012436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635012437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635012438 S-adenosylmethionine binding site [chemical binding]; other site 675635012439 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 675635012440 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 675635012441 catalytic triad [active] 675635012442 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 675635012443 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 675635012444 active site 675635012445 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 675635012446 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 675635012447 Predicted acetyltransferase [General function prediction only]; Region: COG3393 675635012448 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 675635012449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 675635012450 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 675635012451 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 675635012452 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 675635012453 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 675635012454 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 675635012455 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 675635012456 active site 675635012457 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 675635012458 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 675635012459 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 675635012460 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 675635012461 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 675635012462 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 675635012463 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 675635012464 nucleotide binding site [chemical binding]; other site 675635012465 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635012466 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 675635012467 MarR family; Region: MarR; pfam01047 675635012468 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 675635012469 active site 675635012470 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 675635012471 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 675635012472 active site 675635012473 DNA binding site [nucleotide binding] 675635012474 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 675635012475 DNA binding site [nucleotide binding] 675635012476 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 675635012477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635012478 FeS/SAM binding site; other site 675635012479 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635012480 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 675635012481 iron-sulfur cluster [ion binding]; other site 675635012482 [2Fe-2S] cluster binding site [ion binding]; other site 675635012483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635012484 S-adenosylmethionine binding site [chemical binding]; other site 675635012485 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 675635012486 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 675635012487 ribosome recycling factor; Reviewed; Region: frr; PRK00083 675635012488 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 675635012489 hinge region; other site 675635012490 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 675635012491 putative nucleotide binding site [chemical binding]; other site 675635012492 uridine monophosphate binding site [chemical binding]; other site 675635012493 homohexameric interface [polypeptide binding]; other site 675635012494 elongation factor Ts; Provisional; Region: tsf; PRK09377 675635012495 UBA/TS-N domain; Region: UBA; pfam00627 675635012496 Elongation factor TS; Region: EF_TS; pfam00889 675635012497 Elongation factor TS; Region: EF_TS; pfam00889 675635012498 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 675635012499 rRNA interaction site [nucleotide binding]; other site 675635012500 S8 interaction site; other site 675635012501 putative laminin-1 binding site; other site 675635012502 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635012503 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 675635012504 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635012505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635012506 DNA binding residues [nucleotide binding] 675635012507 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 675635012508 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635012509 active site 675635012510 DNA binding site [nucleotide binding] 675635012511 Int/Topo IB signature motif; other site 675635012512 DNA protecting protein DprA; Region: dprA; TIGR00732 675635012513 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 675635012514 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 675635012515 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 675635012516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635012517 Walker A motif; other site 675635012518 ATP binding site [chemical binding]; other site 675635012519 Walker B motif; other site 675635012520 arginine finger; other site 675635012521 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 675635012522 hypothetical protein; Reviewed; Region: PRK12497 675635012523 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 675635012524 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 675635012525 RNA/DNA hybrid binding site [nucleotide binding]; other site 675635012526 active site 675635012527 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 675635012528 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 675635012529 Catalytic site [active] 675635012530 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 675635012531 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 675635012532 MgtC family; Region: MgtC; pfam02308 675635012533 Clp amino terminal domain; Region: Clp_N; pfam02861 675635012534 Clp amino terminal domain; Region: Clp_N; pfam02861 675635012535 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 675635012536 RimM N-terminal domain; Region: RimM; pfam01782 675635012537 hypothetical protein; Provisional; Region: PRK02821 675635012538 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 675635012539 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 675635012540 CAAX protease self-immunity; Region: Abi; pfam02517 675635012541 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635012542 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635012543 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635012544 active site 675635012545 signal recognition particle protein; Provisional; Region: PRK10867 675635012546 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 675635012547 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 675635012548 P loop; other site 675635012549 GTP binding site [chemical binding]; other site 675635012550 Signal peptide binding domain; Region: SRP_SPB; pfam02978 675635012551 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 675635012552 Nitrogen regulatory protein P-II; Region: P-II; smart00938 675635012553 PII uridylyl-transferase; Provisional; Region: PRK03381 675635012554 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 675635012555 metal binding triad; other site 675635012556 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 675635012557 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 675635012558 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 675635012559 Nitrogen regulatory protein P-II; Region: P-II; smart00938 675635012560 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 675635012561 Nitrogen regulatory protein P-II; Region: P-II; smart00938 675635012562 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 675635012563 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 675635012564 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 675635012565 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 675635012566 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 675635012567 AAA domain; Region: AAA_23; pfam13476 675635012568 Walker A/P-loop; other site 675635012569 ATP binding site [chemical binding]; other site 675635012570 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 675635012571 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 675635012572 ABC transporter signature motif; other site 675635012573 Walker B; other site 675635012574 D-loop; other site 675635012575 H-loop/switch region; other site 675635012576 Acylphosphatase; Region: Acylphosphatase; cl00551 675635012577 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 675635012578 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 675635012579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635012580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635012581 active site 675635012582 phosphorylation site [posttranslational modification] 675635012583 intermolecular recognition site; other site 675635012584 dimerization interface [polypeptide binding]; other site 675635012585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635012586 DNA binding site [nucleotide binding] 675635012587 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 675635012588 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 675635012589 oligomer interface [polypeptide binding]; other site 675635012590 metal binding site [ion binding]; metal-binding site 675635012591 metal binding site [ion binding]; metal-binding site 675635012592 putative Cl binding site [ion binding]; other site 675635012593 basic sphincter; other site 675635012594 hydrophobic gate; other site 675635012595 periplasmic entrance; other site 675635012596 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 675635012597 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 675635012598 DNA binding site [nucleotide binding] 675635012599 catalytic residue [active] 675635012600 H2TH interface [polypeptide binding]; other site 675635012601 putative catalytic residues [active] 675635012602 turnover-facilitating residue; other site 675635012603 intercalation triad [nucleotide binding]; other site 675635012604 8OG recognition residue [nucleotide binding]; other site 675635012605 putative reading head residues; other site 675635012606 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 675635012607 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 675635012608 ribonuclease III; Reviewed; Region: rnc; PRK00102 675635012609 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 675635012610 dimerization interface [polypeptide binding]; other site 675635012611 active site 675635012612 metal binding site [ion binding]; metal-binding site 675635012613 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 675635012614 dsRNA binding site [nucleotide binding]; other site 675635012615 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 675635012616 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 675635012617 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 675635012618 V-type ATP synthase subunit E; Provisional; Region: PRK01558 675635012619 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 675635012620 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 675635012621 active site 675635012622 (T/H)XGH motif; other site 675635012623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635012624 S-adenosylmethionine binding site [chemical binding]; other site 675635012625 pyruvate carboxylase; Reviewed; Region: PRK12999 675635012626 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635012627 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635012628 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 675635012629 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 675635012630 active site 675635012631 catalytic residues [active] 675635012632 metal binding site [ion binding]; metal-binding site 675635012633 homodimer binding site [polypeptide binding]; other site 675635012634 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635012635 carboxyltransferase (CT) interaction site; other site 675635012636 biotinylation site [posttranslational modification]; other site 675635012637 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 675635012638 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 675635012639 generic binding surface II; other site 675635012640 ssDNA binding site; other site 675635012641 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635012642 ATP binding site [chemical binding]; other site 675635012643 putative Mg++ binding site [ion binding]; other site 675635012644 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635012645 nucleotide binding region [chemical binding]; other site 675635012646 ATP-binding site [chemical binding]; other site 675635012647 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 675635012648 DAK2 domain; Region: Dak2; cl03685 675635012649 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 675635012650 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 675635012651 ligand binding site [chemical binding]; other site 675635012652 active site 675635012653 UGI interface [polypeptide binding]; other site 675635012654 catalytic site [active] 675635012655 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 675635012656 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 675635012657 trimer interface [polypeptide binding]; other site 675635012658 putative metal binding site [ion binding]; other site 675635012659 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 675635012660 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 675635012661 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 675635012662 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 675635012663 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 675635012664 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 675635012665 active site 675635012666 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 675635012667 FAD binding domain; Region: FAD_binding_4; pfam01565 675635012668 FAD binding domain; Region: FAD_binding_4; pfam01565 675635012669 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 675635012670 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 675635012671 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 675635012672 Cysteine-rich domain; Region: CCG; pfam02754 675635012673 Cysteine-rich domain; Region: CCG; pfam02754 675635012674 DinB superfamily; Region: DinB_2; pfam12867 675635012675 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635012676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635012677 DNA-binding site [nucleotide binding]; DNA binding site 675635012678 FCD domain; Region: FCD; pfam07729 675635012679 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 675635012680 FAD binding domain; Region: FAD_binding_4; pfam01565 675635012681 FAD binding domain; Region: FAD_binding_4; pfam01565 675635012682 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 675635012683 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 675635012684 Cysteine-rich domain; Region: CCG; pfam02754 675635012685 Cysteine-rich domain; Region: CCG; pfam02754 675635012686 thiamine monophosphate kinase; Provisional; Region: PRK05731 675635012687 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 675635012688 ATP binding site [chemical binding]; other site 675635012689 dimerization interface [polypeptide binding]; other site 675635012690 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635012691 AsnC family; Region: AsnC_trans_reg; pfam01037 675635012692 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 675635012693 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 675635012694 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 675635012695 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 675635012696 acetyl-CoA synthetase; Provisional; Region: PRK00174 675635012697 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635012698 acyl-activating enzyme (AAE) consensus motif; other site 675635012699 AMP binding site [chemical binding]; other site 675635012700 active site 675635012701 CoA binding site [chemical binding]; other site 675635012702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635012703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635012704 active site 675635012705 Isochorismatase family; Region: Isochorismatase; pfam00857 675635012706 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 675635012707 catalytic triad [active] 675635012708 conserved cis-peptide bond; other site 675635012709 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 675635012710 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 675635012711 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635012712 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 675635012713 Mechanosensitive ion channel; Region: MS_channel; pfam00924 675635012714 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 675635012715 apolar tunnel; other site 675635012716 heme binding site [chemical binding]; other site 675635012717 dimerization interface [polypeptide binding]; other site 675635012718 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 675635012719 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 675635012720 active site 675635012721 catalytic site [active] 675635012722 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 675635012723 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 675635012724 active site 675635012725 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 675635012726 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 675635012727 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 675635012728 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 675635012729 ABC transporter; Region: ABC_tran_2; pfam12848 675635012730 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 675635012731 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 675635012732 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 675635012733 dimer interface [polypeptide binding]; other site 675635012734 ssDNA binding site [nucleotide binding]; other site 675635012735 tetramer (dimer of dimers) interface [polypeptide binding]; other site 675635012736 Copper resistance protein D; Region: CopD; pfam05425 675635012737 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 675635012738 Protein phosphatase 2C; Region: PP2C; pfam00481 675635012739 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 675635012740 active site 675635012741 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635012742 active site 675635012743 Int/Topo IB signature motif; other site 675635012744 DNA binding site [nucleotide binding] 675635012745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635012746 DNA-binding site [nucleotide binding]; DNA binding site 675635012747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635012748 Integrase core domain; Region: rve; pfam00665 675635012749 transposase/IS protein; Provisional; Region: PRK09183 675635012750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635012751 Walker A motif; other site 675635012752 ATP binding site [chemical binding]; other site 675635012753 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635012754 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 675635012755 Walker A/P-loop; other site 675635012756 ATP binding site [chemical binding]; other site 675635012757 Q-loop/lid; other site 675635012758 ABC transporter signature motif; other site 675635012759 Walker B; other site 675635012760 D-loop; other site 675635012761 H-loop/switch region; other site 675635012762 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 675635012763 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 675635012764 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 675635012765 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 675635012766 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 675635012767 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635012768 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635012769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635012770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 675635012771 dimerization interface [polypeptide binding]; other site 675635012772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635012773 dimer interface [polypeptide binding]; other site 675635012774 phosphorylation site [posttranslational modification] 675635012775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635012776 ATP binding site [chemical binding]; other site 675635012777 Mg2+ binding site [ion binding]; other site 675635012778 G-X-G motif; other site 675635012779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635012780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635012781 active site 675635012782 phosphorylation site [posttranslational modification] 675635012783 intermolecular recognition site; other site 675635012784 dimerization interface [polypeptide binding]; other site 675635012785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635012786 DNA binding site [nucleotide binding] 675635012787 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635012788 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 675635012789 active site 675635012790 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 675635012791 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 675635012792 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 675635012793 HAMP domain; Region: HAMP; pfam00672 675635012794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635012795 dimer interface [polypeptide binding]; other site 675635012796 phosphorylation site [posttranslational modification] 675635012797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635012798 ATP binding site [chemical binding]; other site 675635012799 Mg2+ binding site [ion binding]; other site 675635012800 G-X-G motif; other site 675635012801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635012802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635012803 active site 675635012804 phosphorylation site [posttranslational modification] 675635012805 intermolecular recognition site; other site 675635012806 dimerization interface [polypeptide binding]; other site 675635012807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635012808 DNA binding site [nucleotide binding] 675635012809 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 675635012810 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 675635012811 Imelysin; Region: Peptidase_M75; pfam09375 675635012812 Iron permease FTR1 family; Region: FTR1; pfam03239 675635012813 Penicillinase repressor; Region: Pencillinase_R; cl17580 675635012814 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 675635012815 Acetokinase family; Region: Acetate_kinase; cl17229 675635012816 putative phosphoketolase; Provisional; Region: PRK05261 675635012817 XFP N-terminal domain; Region: XFP_N; pfam09364 675635012818 XFP C-terminal domain; Region: XFP_C; pfam09363 675635012819 FOG: CBS domain [General function prediction only]; Region: COG0517 675635012820 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635012821 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635012822 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635012823 Ligand Binding Site [chemical binding]; other site 675635012824 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635012825 Ligand Binding Site [chemical binding]; other site 675635012826 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 675635012827 Ligand Binding Site [chemical binding]; other site 675635012828 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 675635012829 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 675635012830 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 675635012831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 675635012832 Predicted kinase [General function prediction only]; Region: COG0645 675635012833 AAA domain; Region: AAA_17; pfam13207 675635012834 FOG: CBS domain [General function prediction only]; Region: COG0517 675635012835 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 675635012836 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 675635012837 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635012838 Hemerythrin-like domain; Region: Hr-like; cd12108 675635012839 PAS domain; Region: PAS_9; pfam13426 675635012840 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635012841 Helix-turn-helix domain; Region: HTH_38; pfam13936 675635012842 Integrase core domain; Region: rve; pfam00665 675635012843 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 675635012844 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635012845 active site 675635012846 catalytic residues [active] 675635012847 DNA binding site [nucleotide binding] 675635012848 Int/Topo IB signature motif; other site 675635012849 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 675635012850 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635012851 active site 675635012852 catalytic residues [active] 675635012853 DNA binding site [nucleotide binding] 675635012854 Int/Topo IB signature motif; other site 675635012855 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 675635012856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635012857 Walker A motif; other site 675635012858 ATP binding site [chemical binding]; other site 675635012859 Walker B motif; other site 675635012860 Integrase core domain; Region: rve; pfam00665 675635012861 rod shape-determining protein MreB; Provisional; Region: PRK13930 675635012862 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 675635012863 nucleotide binding site [chemical binding]; other site 675635012864 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 675635012865 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 675635012866 NodB motif; other site 675635012867 putative active site [active] 675635012868 putative catalytic site [active] 675635012869 putative Zn binding site [ion binding]; other site 675635012870 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635012871 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 675635012872 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635012873 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 675635012874 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635012875 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 675635012876 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 675635012877 active site 675635012878 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 675635012879 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 675635012880 active site 675635012881 Penicillinase repressor; Region: Pencillinase_R; pfam03965 675635012882 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 675635012883 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 675635012884 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 675635012885 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 675635012886 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 675635012887 Class I aldolases; Region: Aldolase_Class_I; cl17187 675635012888 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 675635012889 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 675635012890 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 675635012891 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 675635012892 active site 675635012893 catalytic triad [active] 675635012894 dimer interface [polypeptide binding]; other site 675635012895 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635012896 MarR family; Region: MarR_2; pfam12802 675635012897 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 675635012898 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 675635012899 catalytic residues [active] 675635012900 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 675635012901 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 675635012902 Winged helix-turn helix; Region: HTH_29; pfam13551 675635012903 Homeodomain-like domain; Region: HTH_32; pfam13565 675635012904 DDE superfamily endonuclease; Region: DDE_3; pfam13358 675635012905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 675635012906 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635012907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635012908 DNA binding residues [nucleotide binding] 675635012909 dimerization interface [polypeptide binding]; other site 675635012910 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 675635012911 Tubulin like; Region: Tubulin_2; pfam13809 675635012912 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 675635012913 hypothetical protein; Provisional; Region: PRK07236 675635012914 hypothetical protein; Validated; Region: PRK05868 675635012915 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 675635012916 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 675635012917 active site residue [active] 675635012918 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635012919 active site residue [active] 675635012920 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 675635012921 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635012922 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635012923 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635012924 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635012925 substrate binding site [chemical binding]; other site 675635012926 oxyanion hole (OAH) forming residues; other site 675635012927 trimer interface [polypeptide binding]; other site 675635012928 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635012929 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635012930 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635012931 active site 675635012932 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635012933 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635012934 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635012935 acyl-activating enzyme (AAE) consensus motif; other site 675635012936 acyl-activating enzyme (AAE) consensus motif; other site 675635012937 putative AMP binding site [chemical binding]; other site 675635012938 putative active site [active] 675635012939 putative CoA binding site [chemical binding]; other site 675635012940 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635012941 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635012942 catalytic site [active] 675635012943 TAP-like protein; Region: Abhydrolase_4; pfam08386 675635012944 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 675635012945 Methyltransferase domain; Region: Methyltransf_31; pfam13847 675635012946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635012947 S-adenosylmethionine binding site [chemical binding]; other site 675635012948 AAA ATPase domain; Region: AAA_16; pfam13191 675635012949 Walker A motif; other site 675635012950 ATP binding site [chemical binding]; other site 675635012951 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635012952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635012953 DNA binding residues [nucleotide binding] 675635012954 dimerization interface [polypeptide binding]; other site 675635012955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635012956 DNA-binding site [nucleotide binding]; DNA binding site 675635012957 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635012958 FCD domain; Region: FCD; pfam07729 675635012959 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 675635012960 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 675635012961 active site 675635012962 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 675635012963 domain_subunit interface; other site 675635012964 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 675635012965 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 675635012966 active site 675635012967 FMN binding site [chemical binding]; other site 675635012968 substrate binding site [chemical binding]; other site 675635012969 3Fe-4S cluster binding site [ion binding]; other site 675635012970 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 675635012971 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 675635012972 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 675635012973 hydroxyglutarate oxidase; Provisional; Region: PRK11728 675635012974 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 675635012975 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 675635012976 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 675635012977 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 675635012978 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 675635012979 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 675635012980 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 675635012981 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 675635012982 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 675635012983 putative active site [active] 675635012984 putative substrate binding site [chemical binding]; other site 675635012985 putative cosubstrate binding site; other site 675635012986 catalytic site [active] 675635012987 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 675635012988 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 675635012989 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 675635012990 homodimer interface [polypeptide binding]; other site 675635012991 NADP binding site [chemical binding]; other site 675635012992 substrate binding site [chemical binding]; other site 675635012993 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 675635012994 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635012995 dimer interface [polypeptide binding]; other site 675635012996 active site 675635012997 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 675635012998 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635012999 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635013000 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635013001 active site 675635013002 non-prolyl cis peptide bond; other site 675635013003 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 675635013004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635013005 dimer interface [polypeptide binding]; other site 675635013006 conserved gate region; other site 675635013007 putative PBP binding loops; other site 675635013008 ABC-ATPase subunit interface; other site 675635013009 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 675635013010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635013011 Walker A/P-loop; other site 675635013012 ATP binding site [chemical binding]; other site 675635013013 Q-loop/lid; other site 675635013014 ABC transporter signature motif; other site 675635013015 Walker B; other site 675635013016 D-loop; other site 675635013017 H-loop/switch region; other site 675635013018 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 675635013019 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 675635013020 substrate binding pocket [chemical binding]; other site 675635013021 membrane-bound complex binding site; other site 675635013022 hinge residues; other site 675635013023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635013024 Coenzyme A binding pocket [chemical binding]; other site 675635013025 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 675635013026 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 675635013027 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 675635013028 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 675635013029 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635013030 Walker A/P-loop; other site 675635013031 ATP binding site [chemical binding]; other site 675635013032 Q-loop/lid; other site 675635013033 ABC transporter signature motif; other site 675635013034 Walker B; other site 675635013035 D-loop; other site 675635013036 H-loop/switch region; other site 675635013037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635013038 Walker A/P-loop; other site 675635013039 ATP binding site [chemical binding]; other site 675635013040 Q-loop/lid; other site 675635013041 ABC transporter signature motif; other site 675635013042 Walker B; other site 675635013043 D-loop; other site 675635013044 H-loop/switch region; other site 675635013045 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635013046 MarR family; Region: MarR; pfam01047 675635013047 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635013048 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635013049 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635013050 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 675635013051 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635013052 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635013053 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635013054 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635013055 substrate binding site [chemical binding]; other site 675635013056 oxyanion hole (OAH) forming residues; other site 675635013057 trimer interface [polypeptide binding]; other site 675635013058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635013059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635013060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635013061 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635013062 putative substrate translocation pore; other site 675635013063 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635013064 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635013065 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 675635013066 Predicted transcriptional regulators [Transcription]; Region: COG1733 675635013067 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 675635013068 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 675635013069 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635013070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635013071 putative DNA binding site [nucleotide binding]; other site 675635013072 dimerization interface [polypeptide binding]; other site 675635013073 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635013074 putative Zn2+ binding site [ion binding]; other site 675635013075 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635013076 hydrophobic ligand binding site; other site 675635013077 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 675635013078 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635013079 FAD binding domain; Region: FAD_binding_4; pfam01565 675635013080 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 675635013081 sensor protein QseC; Provisional; Region: PRK10337 675635013082 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 675635013083 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635013084 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635013085 HicB family; Region: HicB; pfam05534 675635013086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635013087 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 675635013088 Walker A/P-loop; other site 675635013089 ATP binding site [chemical binding]; other site 675635013090 Q-loop/lid; other site 675635013091 ABC transporter signature motif; other site 675635013092 Walker B; other site 675635013093 D-loop; other site 675635013094 H-loop/switch region; other site 675635013095 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 675635013096 ABC-2 type transporter; Region: ABC2_membrane; cl17235 675635013097 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635013098 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635013099 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 675635013100 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 675635013101 active site 675635013102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635013103 S-adenosylmethionine binding site [chemical binding]; other site 675635013104 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 675635013105 substrate binding site [chemical binding]; other site 675635013106 metal binding site [ion binding]; metal-binding site 675635013107 dimer interface [polypeptide binding]; other site 675635013108 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635013109 E3 interaction surface; other site 675635013110 lipoyl attachment site [posttranslational modification]; other site 675635013111 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635013112 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 675635013113 PYR/PP interface [polypeptide binding]; other site 675635013114 dimer interface [polypeptide binding]; other site 675635013115 TPP binding site [chemical binding]; other site 675635013116 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635013117 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 675635013118 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635013119 tetramer interface [polypeptide binding]; other site 675635013120 TPP-binding site [chemical binding]; other site 675635013121 heterodimer interface [polypeptide binding]; other site 675635013122 phosphorylation loop region [posttranslational modification] 675635013123 Predicted transcriptional regulator [Transcription]; Region: COG1959 675635013124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635013125 putative Zn2+ binding site [ion binding]; other site 675635013126 putative DNA binding site [nucleotide binding]; other site 675635013127 dimerization interface [polypeptide binding]; other site 675635013128 NADH(P)-binding; Region: NAD_binding_10; pfam13460 675635013129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013130 NAD(P) binding site [chemical binding]; other site 675635013131 active site 675635013132 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635013133 MarR family; Region: MarR; pfam01047 675635013134 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 675635013135 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 675635013136 Cl- selectivity filter; other site 675635013137 Cl- binding residues [ion binding]; other site 675635013138 pore gating glutamate residue; other site 675635013139 dimer interface [polypeptide binding]; other site 675635013140 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 675635013141 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635013142 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635013143 substrate binding site [chemical binding]; other site 675635013144 oxyanion hole (OAH) forming residues; other site 675635013145 trimer interface [polypeptide binding]; other site 675635013146 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635013147 DNA binding residues [nucleotide binding] 675635013148 TOBE domain; Region: TOBE; cl01440 675635013149 Amidohydrolase; Region: Amidohydro_2; pfam04909 675635013150 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 675635013151 Isochorismatase family; Region: Isochorismatase; pfam00857 675635013152 catalytic triad [active] 675635013153 conserved cis-peptide bond; other site 675635013154 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635013155 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 675635013156 NAD(P) binding site [chemical binding]; other site 675635013157 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635013158 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635013159 active site 675635013160 catalytic tetrad [active] 675635013161 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635013162 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 675635013163 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 675635013164 active site 675635013165 DNA binding site [nucleotide binding] 675635013166 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 675635013167 DNA binding site [nucleotide binding] 675635013168 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 675635013169 nucleotide binding site [chemical binding]; other site 675635013170 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635013171 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 675635013172 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 675635013173 Sulfate transporter family; Region: Sulfate_transp; pfam00916 675635013174 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 675635013175 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635013176 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635013177 putative NAD(P) binding site [chemical binding]; other site 675635013178 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635013179 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635013180 putative NAD(P) binding site [chemical binding]; other site 675635013181 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 675635013182 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 675635013183 Moco binding site; other site 675635013184 metal coordination site [ion binding]; other site 675635013185 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 675635013186 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 675635013187 FAD binding pocket [chemical binding]; other site 675635013188 conserved FAD binding motif [chemical binding]; other site 675635013189 phosphate binding motif [ion binding]; other site 675635013190 beta-alpha-beta structure motif; other site 675635013191 NAD binding pocket [chemical binding]; other site 675635013192 methionine sulfoxide reductase A; Provisional; Region: PRK14054 675635013193 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 675635013194 putative uracil binding site [chemical binding]; other site 675635013195 putative active site [active] 675635013196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635013197 Coenzyme A binding pocket [chemical binding]; other site 675635013198 OsmC-like protein; Region: OsmC; pfam02566 675635013199 DAK2 domain; Region: Dak2; cl03685 675635013200 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 675635013201 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 675635013202 D-pathway; other site 675635013203 Putative ubiquinol binding site [chemical binding]; other site 675635013204 Low-spin heme (heme b) binding site [chemical binding]; other site 675635013205 Putative water exit pathway; other site 675635013206 Binuclear center (heme o3/CuB) [ion binding]; other site 675635013207 K-pathway; other site 675635013208 Putative proton exit pathway; other site 675635013209 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 675635013210 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 675635013211 dimerization interface [polypeptide binding]; other site 675635013212 DPS ferroxidase diiron center [ion binding]; other site 675635013213 ion pore; other site 675635013214 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 675635013215 putative active site [active] 675635013216 transaldolase; Provisional; Region: PRK03903 675635013217 catalytic residue [active] 675635013218 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 675635013219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635013220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635013221 short chain dehydrogenase; Provisional; Region: PRK08263 675635013222 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 675635013223 NADP binding site [chemical binding]; other site 675635013224 active site 675635013225 steroid binding site; other site 675635013226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635013227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635013228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 675635013229 dimerization interface [polypeptide binding]; other site 675635013230 Uncharacterized conserved protein [Function unknown]; Region: COG1359 675635013231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 675635013232 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 675635013233 substrate binding pocket [chemical binding]; other site 675635013234 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 675635013235 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 675635013236 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 675635013237 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 675635013238 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 675635013239 putative substrate binding site [chemical binding]; other site 675635013240 putative ATP binding site [chemical binding]; other site 675635013241 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 675635013242 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635013243 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 675635013244 hypothetical protein; Provisional; Region: PRK07945 675635013245 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 675635013246 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 675635013247 active site 675635013248 CHAD domain; Region: CHAD; pfam05235 675635013249 FAD binding domain; Region: FAD_binding_4; pfam01565 675635013250 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 675635013251 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 675635013252 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 675635013253 O-succinylbenzoate synthase; Provisional; Region: PRK02901 675635013254 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 675635013255 metal binding site [ion binding]; metal-binding site 675635013256 substrate binding pocket [chemical binding]; other site 675635013257 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635013258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635013259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635013260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635013261 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 675635013262 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 675635013263 FAD binding pocket [chemical binding]; other site 675635013264 FAD binding motif [chemical binding]; other site 675635013265 phosphate binding motif [ion binding]; other site 675635013266 NAD binding pocket [chemical binding]; other site 675635013267 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635013268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635013269 active site 675635013270 phosphorylation site [posttranslational modification] 675635013271 intermolecular recognition site; other site 675635013272 dimerization interface [polypeptide binding]; other site 675635013273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635013274 DNA binding site [nucleotide binding] 675635013275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635013276 dimer interface [polypeptide binding]; other site 675635013277 phosphorylation site [posttranslational modification] 675635013278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635013279 ATP binding site [chemical binding]; other site 675635013280 Mg2+ binding site [ion binding]; other site 675635013281 G-X-G motif; other site 675635013282 Bacitracin resistance protein BacA; Region: BacA; pfam02673 675635013283 Transcriptional regulator [Transcription]; Region: LytR; COG1316 675635013284 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635013285 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 675635013286 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635013287 active site 675635013288 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 675635013289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635013290 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 675635013291 putative hydrophobic ligand binding site [chemical binding]; other site 675635013292 protein interface [polypeptide binding]; other site 675635013293 gate; other site 675635013294 acyl-CoA synthetase; Validated; Region: PRK07788 675635013295 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635013296 AMP binding site [chemical binding]; other site 675635013297 active site 675635013298 acyl-activating enzyme (AAE) consensus motif; other site 675635013299 CoA binding site [chemical binding]; other site 675635013300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635013301 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635013302 Bacterial PH domain; Region: DUF304; pfam03703 675635013303 Bacterial PH domain; Region: DUF304; pfam03703 675635013304 Bacterial PH domain; Region: DUF304; pfam03703 675635013305 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 675635013306 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 675635013307 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 675635013308 catalytic site [active] 675635013309 putative active site [active] 675635013310 putative substrate binding site [chemical binding]; other site 675635013311 dimer interface [polypeptide binding]; other site 675635013312 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 675635013313 Flavoprotein; Region: Flavoprotein; pfam02441 675635013314 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 675635013315 catalytic triad [active] 675635013316 Isochorismatase family; Region: Isochorismatase; pfam00857 675635013317 conserved cis-peptide bond; other site 675635013318 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 675635013319 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 675635013320 Walker A/P-loop; other site 675635013321 ATP binding site [chemical binding]; other site 675635013322 Q-loop/lid; other site 675635013323 ABC transporter signature motif; other site 675635013324 Walker B; other site 675635013325 D-loop; other site 675635013326 H-loop/switch region; other site 675635013327 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 675635013328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635013329 dimer interface [polypeptide binding]; other site 675635013330 conserved gate region; other site 675635013331 putative PBP binding loops; other site 675635013332 ABC-ATPase subunit interface; other site 675635013333 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 675635013334 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 675635013335 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 675635013336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635013337 DNA-binding site [nucleotide binding]; DNA binding site 675635013338 FCD domain; Region: FCD; pfam07729 675635013339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635013340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635013341 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 675635013342 putative dimerization interface [polypeptide binding]; other site 675635013343 Amidohydrolase; Region: Amidohydro_2; pfam04909 675635013344 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635013345 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635013346 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635013347 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 675635013348 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635013349 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635013350 catalytic loop [active] 675635013351 iron binding site [ion binding]; other site 675635013352 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635013353 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635013354 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635013355 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635013356 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635013357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013358 NAD(P) binding site [chemical binding]; other site 675635013359 active site 675635013360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635013361 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635013362 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635013363 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635013364 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635013365 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635013366 ligand binding site [chemical binding]; other site 675635013367 flexible hinge region; other site 675635013368 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 675635013369 putative switch regulator; other site 675635013370 non-specific DNA interactions [nucleotide binding]; other site 675635013371 DNA binding site [nucleotide binding] 675635013372 sequence specific DNA binding site [nucleotide binding]; other site 675635013373 putative cAMP binding site [chemical binding]; other site 675635013374 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 675635013375 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 675635013376 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 675635013377 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 675635013378 acyl-activating enzyme (AAE) consensus motif; other site 675635013379 active site 675635013380 AMP binding site [chemical binding]; other site 675635013381 substrate binding site [chemical binding]; other site 675635013382 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 675635013383 CoA binding domain; Region: CoA_binding_2; pfam13380 675635013384 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 675635013385 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 675635013386 hypothetical protein; Provisional; Region: PRK07236 675635013387 FAD binding domain; Region: FAD_binding_3; pfam01494 675635013388 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635013389 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 675635013390 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 675635013391 Cupin domain; Region: Cupin_2; pfam07883 675635013392 PaaX-like protein; Region: PaaX; pfam07848 675635013393 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 675635013394 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 675635013395 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 675635013396 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 675635013397 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 675635013398 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 675635013399 Uncharacterized conserved protein [Function unknown]; Region: COG1359 675635013400 glycerol kinase; Provisional; Region: glpK; PRK00047 675635013401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 675635013402 nucleotide binding site [chemical binding]; other site 675635013403 Transcriptional regulator [Transcription]; Region: IclR; COG1414 675635013404 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 675635013405 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635013406 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 675635013407 amphipathic channel; other site 675635013408 Asn-Pro-Ala signature motifs; other site 675635013409 glycerol kinase; Provisional; Region: glpK; PRK00047 675635013410 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 675635013411 N- and C-terminal domain interface [polypeptide binding]; other site 675635013412 active site 675635013413 MgATP binding site [chemical binding]; other site 675635013414 catalytic site [active] 675635013415 metal binding site [ion binding]; metal-binding site 675635013416 putative homotetramer interface [polypeptide binding]; other site 675635013417 glycerol binding site [chemical binding]; other site 675635013418 homodimer interface [polypeptide binding]; other site 675635013419 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 675635013420 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 675635013421 kynureninase; Region: kynureninase; TIGR01814 675635013422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635013423 catalytic residue [active] 675635013424 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 675635013425 Predicted transcriptional regulator [Transcription]; Region: COG2345 675635013426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635013427 dimerization interface [polypeptide binding]; other site 675635013428 putative DNA binding site [nucleotide binding]; other site 675635013429 putative Zn2+ binding site [ion binding]; other site 675635013430 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 675635013431 Uncharacterized conserved protein [Function unknown]; Region: COG3391 675635013432 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 675635013433 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 675635013434 NodB motif; other site 675635013435 active site 675635013436 catalytic site [active] 675635013437 metal binding site [ion binding]; metal-binding site 675635013438 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 675635013439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635013440 putative substrate translocation pore; other site 675635013441 Putative esterase; Region: Esterase; pfam00756 675635013442 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635013443 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 675635013444 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 675635013445 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 675635013446 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635013447 conserved hypothetical protein; Region: TIGR03843 675635013448 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 675635013449 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635013450 catalytic core [active] 675635013451 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 675635013452 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635013453 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635013454 active site 675635013455 catalytic tetrad [active] 675635013456 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635013457 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 675635013458 NAD(P) binding site [chemical binding]; other site 675635013459 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 675635013460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013461 NAD(P) binding site [chemical binding]; other site 675635013462 active site 675635013463 hypothetical protein; Provisional; Region: PRK07906 675635013464 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 675635013465 putative metal binding site [ion binding]; other site 675635013466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635013467 catalytic core [active] 675635013468 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635013469 MarR family; Region: MarR_2; pfam12802 675635013470 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 675635013471 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635013472 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635013473 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 675635013474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635013475 FeS/SAM binding site; other site 675635013476 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 675635013477 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 675635013478 glutaminase active site [active] 675635013479 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 675635013480 dimer interface [polypeptide binding]; other site 675635013481 active site 675635013482 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 675635013483 dimer interface [polypeptide binding]; other site 675635013484 active site 675635013485 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 675635013486 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 675635013487 putative active site [active] 675635013488 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635013489 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 675635013490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635013491 Walker A/P-loop; other site 675635013492 ATP binding site [chemical binding]; other site 675635013493 Q-loop/lid; other site 675635013494 ABC transporter signature motif; other site 675635013495 Walker B; other site 675635013496 D-loop; other site 675635013497 H-loop/switch region; other site 675635013498 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635013499 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 675635013500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635013501 Walker A/P-loop; other site 675635013502 ATP binding site [chemical binding]; other site 675635013503 Q-loop/lid; other site 675635013504 ABC transporter signature motif; other site 675635013505 Walker B; other site 675635013506 D-loop; other site 675635013507 H-loop/switch region; other site 675635013508 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635013509 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635013510 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635013511 acyl-activating enzyme (AAE) consensus motif; other site 675635013512 acyl-activating enzyme (AAE) consensus motif; other site 675635013513 putative AMP binding site [chemical binding]; other site 675635013514 putative active site [active] 675635013515 putative CoA binding site [chemical binding]; other site 675635013516 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635013517 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635013518 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 675635013519 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 675635013520 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 675635013521 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 675635013522 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 675635013523 TPP-binding site [chemical binding]; other site 675635013524 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 675635013525 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 675635013526 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635013527 multicopper oxidase; Provisional; Region: PRK10965 675635013528 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 675635013529 Multicopper oxidase; Region: Cu-oxidase; pfam00394 675635013530 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 675635013531 Predicted transcriptional regulators [Transcription]; Region: COG1695 675635013532 Transcriptional regulator PadR-like family; Region: PadR; cl17335 675635013533 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635013534 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635013535 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 675635013536 short chain dehydrogenase; Provisional; Region: PRK08303 675635013537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635013538 NAD(P) binding site [chemical binding]; other site 675635013539 active site 675635013540 Predicted transcriptional regulators [Transcription]; Region: COG1695 675635013541 Transcriptional regulator PadR-like family; Region: PadR; cl17335 675635013542 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 675635013543 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 675635013544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635013545 dimer interface [polypeptide binding]; other site 675635013546 conserved gate region; other site 675635013547 putative PBP binding loops; other site 675635013548 ABC-ATPase subunit interface; other site 675635013549 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 675635013550 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 675635013551 Walker A/P-loop; other site 675635013552 ATP binding site [chemical binding]; other site 675635013553 Q-loop/lid; other site 675635013554 ABC transporter signature motif; other site 675635013555 Walker B; other site 675635013556 D-loop; other site 675635013557 H-loop/switch region; other site 675635013558 PAS domain; Region: PAS_9; pfam13426 675635013559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635013560 PAS domain; Region: PAS_9; pfam13426 675635013561 putative active site [active] 675635013562 heme pocket [chemical binding]; other site 675635013563 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 675635013564 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 675635013565 metal binding site [ion binding]; metal-binding site 675635013566 active site 675635013567 I-site; other site 675635013568 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 675635013569 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 675635013570 Malic enzyme, N-terminal domain; Region: malic; pfam00390 675635013571 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 675635013572 NAD(P) binding pocket [chemical binding]; other site 675635013573 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635013574 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 675635013575 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635013576 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 675635013577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635013578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635013579 active site 675635013580 phosphorylation site [posttranslational modification] 675635013581 intermolecular recognition site; other site 675635013582 dimerization interface [polypeptide binding]; other site 675635013583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635013584 DNA binding site [nucleotide binding] 675635013585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635013586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635013587 dimer interface [polypeptide binding]; other site 675635013588 phosphorylation site [posttranslational modification] 675635013589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635013590 ATP binding site [chemical binding]; other site 675635013591 Mg2+ binding site [ion binding]; other site 675635013592 G-X-G motif; other site 675635013593 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 675635013594 Catalytic site [active] 675635013595 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 675635013596 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 675635013597 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 675635013598 active site 675635013599 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 675635013600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635013601 S-adenosylmethionine binding site [chemical binding]; other site 675635013602 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635013603 catalytic core [active] 675635013604 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 675635013605 putative acetyltransferase; Provisional; Region: PRK03624 675635013606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635013607 Coenzyme A binding pocket [chemical binding]; other site 675635013608 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 675635013609 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 675635013610 Transcription factor WhiB; Region: Whib; pfam02467 675635013611 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 675635013612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 675635013613 putative active site [active] 675635013614 heme pocket [chemical binding]; other site 675635013615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 675635013616 Histidine kinase; Region: HisKA_2; pfam07568 675635013617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635013618 ATP binding site [chemical binding]; other site 675635013619 Mg2+ binding site [ion binding]; other site 675635013620 G-X-G motif; other site 675635013621 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 675635013622 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 675635013623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635013624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635013625 DNA binding residues [nucleotide binding] 675635013626 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 675635013627 putative deacylase active site [active] 675635013628 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 675635013629 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 675635013630 Uncharacterized conserved protein [Function unknown]; Region: COG2135 675635013631 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 675635013632 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 675635013633 hinge; other site 675635013634 active site 675635013635 Predicted GTPases [General function prediction only]; Region: COG1162 675635013636 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 675635013637 GTPase/Zn-binding domain interface [polypeptide binding]; other site 675635013638 GTP/Mg2+ binding site [chemical binding]; other site 675635013639 G4 box; other site 675635013640 G5 box; other site 675635013641 G1 box; other site 675635013642 Switch I region; other site 675635013643 G2 box; other site 675635013644 G3 box; other site 675635013645 Switch II region; other site 675635013646 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635013647 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635013648 active site 675635013649 ATP binding site [chemical binding]; other site 675635013650 substrate binding site [chemical binding]; other site 675635013651 activation loop (A-loop); other site 675635013652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635013653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635013654 WHG domain; Region: WHG; pfam13305 675635013655 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 675635013656 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 675635013657 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 675635013658 NAD(P) binding site [chemical binding]; other site 675635013659 catalytic residues [active] 675635013660 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635013661 enoyl-CoA hydratase; Provisional; Region: PRK08260 675635013662 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635013663 substrate binding site [chemical binding]; other site 675635013664 oxyanion hole (OAH) forming residues; other site 675635013665 trimer interface [polypeptide binding]; other site 675635013666 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 675635013667 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 675635013668 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 675635013669 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 675635013670 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 675635013671 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 675635013672 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 675635013673 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635013674 phosphate binding site [ion binding]; other site 675635013675 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 675635013676 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635013677 MarR family; Region: MarR; pfam01047 675635013678 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 675635013679 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 675635013680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 675635013681 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 675635013682 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 675635013683 30S subunit binding site; other site 675635013684 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 675635013685 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635013686 active site 675635013687 lipoprotein LpqB; Provisional; Region: PRK13616 675635013688 Sporulation and spore germination; Region: Germane; pfam10646 675635013689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635013690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 675635013691 dimerization interface [polypeptide binding]; other site 675635013692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635013693 dimer interface [polypeptide binding]; other site 675635013694 phosphorylation site [posttranslational modification] 675635013695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635013696 ATP binding site [chemical binding]; other site 675635013697 Mg2+ binding site [ion binding]; other site 675635013698 G-X-G motif; other site 675635013699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635013700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635013701 active site 675635013702 phosphorylation site [posttranslational modification] 675635013703 intermolecular recognition site; other site 675635013704 dimerization interface [polypeptide binding]; other site 675635013705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635013706 DNA binding site [nucleotide binding] 675635013707 thymidylate kinase; Provisional; Region: PRK13975; cl17243 675635013708 NUDIX domain; Region: NUDIX; pfam00293 675635013709 nudix motif; other site 675635013710 nudix motif; other site 675635013711 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 675635013712 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 675635013713 homotetramer interface [polypeptide binding]; other site 675635013714 ligand binding site [chemical binding]; other site 675635013715 catalytic site [active] 675635013716 NAD binding site [chemical binding]; other site 675635013717 MutL protein; Region: MutL; pfam13941 675635013718 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635013719 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 675635013720 dimer interface [polypeptide binding]; other site 675635013721 acyl-activating enzyme (AAE) consensus motif; other site 675635013722 putative active site [active] 675635013723 AMP binding site [chemical binding]; other site 675635013724 putative CoA binding site [chemical binding]; other site 675635013725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635013726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635013727 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635013728 Predicted membrane protein [Function unknown]; Region: COG2855 675635013729 amino acid transporter; Region: 2A0306; TIGR00909 675635013730 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 675635013731 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 675635013732 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 675635013733 hexamer interface [polypeptide binding]; other site 675635013734 ligand binding site [chemical binding]; other site 675635013735 putative active site [active] 675635013736 NAD(P) binding site [chemical binding]; other site 675635013737 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635013738 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 675635013739 putative DNA binding site [nucleotide binding]; other site 675635013740 putative Zn2+ binding site [ion binding]; other site 675635013741 AsnC family; Region: AsnC_trans_reg; pfam01037 675635013742 Cation efflux family; Region: Cation_efflux; pfam01545 675635013743 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 675635013744 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 675635013745 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 675635013746 Trm112p-like protein; Region: Trm112p; cl01066 675635013747 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 675635013748 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 675635013749 active site 675635013750 substrate binding site [chemical binding]; other site 675635013751 metal binding site [ion binding]; metal-binding site 675635013752 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 675635013753 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 675635013754 Transcription factor WhiB; Region: Whib; pfam02467 675635013755 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 675635013756 Peptidase family M50; Region: Peptidase_M50; pfam02163 675635013757 active site 675635013758 putative substrate binding region [chemical binding]; other site 675635013759 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 675635013760 nudix motif; other site 675635013761 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 675635013762 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 675635013763 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 675635013764 FMN binding site [chemical binding]; other site 675635013765 dimer interface [polypeptide binding]; other site 675635013766 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 675635013767 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 675635013768 dimer interface [polypeptide binding]; other site 675635013769 phosphate binding site [ion binding]; other site 675635013770 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 675635013771 catalytic residues [active] 675635013772 dimer interface [polypeptide binding]; other site 675635013773 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 675635013774 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 675635013775 minor groove reading motif; other site 675635013776 helix-hairpin-helix signature motif; other site 675635013777 active site 675635013778 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 675635013779 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 675635013780 active site 675635013781 Substrate binding site; other site 675635013782 Mg++ binding site; other site 675635013783 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 675635013784 putative CoA binding site [chemical binding]; other site 675635013785 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 675635013786 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635013787 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635013788 active site 675635013789 Transcriptional regulator [Transcription]; Region: LytR; COG1316 675635013790 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635013791 TIGR03089 family protein; Region: TIGR03089 675635013792 threonine dehydratase; Validated; Region: PRK08639 675635013793 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 675635013794 tetramer interface [polypeptide binding]; other site 675635013795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635013796 catalytic residue [active] 675635013797 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 675635013798 putative Ile/Val binding site [chemical binding]; other site 675635013799 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 675635013800 Creatinine amidohydrolase; Region: Creatininase; pfam02633 675635013801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635013802 non-specific DNA binding site [nucleotide binding]; other site 675635013803 salt bridge; other site 675635013804 sequence-specific DNA binding site [nucleotide binding]; other site 675635013805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 675635013806 TPR motif; other site 675635013807 binding surface 675635013808 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635013809 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 675635013810 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635013811 Helix-turn-helix domain; Region: HTH_17; pfam12728 675635013812 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635013813 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635013814 active site 675635013815 catalytic residues [active] 675635013816 DNA binding site [nucleotide binding] 675635013817 Int/Topo IB signature motif; other site 675635013818 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635013819 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635013820 active site 675635013821 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635013822 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 675635013823 AIR carboxylase; Region: AIRC; pfam00731 675635013824 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 675635013825 ATP-grasp domain; Region: ATP-grasp; pfam02222 675635013826 Predicted membrane protein [Function unknown]; Region: COG2246 675635013827 GtrA-like protein; Region: GtrA; pfam04138 675635013828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635013829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635013830 ATP binding site [chemical binding]; other site 675635013831 Mg2+ binding site [ion binding]; other site 675635013832 G-X-G motif; other site 675635013833 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635013834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635013835 active site 675635013836 phosphorylation site [posttranslational modification] 675635013837 intermolecular recognition site; other site 675635013838 dimerization interface [polypeptide binding]; other site 675635013839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635013840 DNA binding site [nucleotide binding] 675635013841 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 675635013842 active site 675635013843 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 675635013844 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 675635013845 putative active site [active] 675635013846 putative catalytic site [active] 675635013847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635013848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635013849 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 675635013850 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 675635013851 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 675635013852 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 675635013853 tetramer interface [polypeptide binding]; other site 675635013854 active site 675635013855 Mg2+/Mn2+ binding site [ion binding]; other site 675635013856 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 675635013857 dimer interface [polypeptide binding]; other site 675635013858 FMN binding site [chemical binding]; other site 675635013859 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635013860 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635013861 putative NAD(P) binding site [chemical binding]; other site 675635013862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 675635013863 CGNR zinc finger; Region: zf-CGNR; pfam11706 675635013864 Transcriptional regulator; Region: Rrf2; cl17282 675635013865 Predicted transcriptional regulator [Transcription]; Region: COG1959 675635013866 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635013867 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635013868 active site 675635013869 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 675635013870 LytTr DNA-binding domain; Region: LytTR; smart00850 675635013871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635013872 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635013873 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635013874 active site 675635013875 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 675635013876 active site 675635013877 catalytic residues [active] 675635013878 metal binding site [ion binding]; metal-binding site 675635013879 Bacterial PH domain; Region: DUF304; pfam03703 675635013880 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 675635013881 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 675635013882 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 675635013883 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 675635013884 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 675635013885 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 675635013886 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 675635013887 Maf-like protein; Region: Maf; pfam02545 675635013888 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 675635013889 active site 675635013890 dimer interface [polypeptide binding]; other site 675635013891 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 675635013892 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 675635013893 active site residue [active] 675635013894 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 675635013895 active site residue [active] 675635013896 Fe-S metabolism associated domain; Region: SufE; cl00951 675635013897 TIGR04222 domain; Region: near_uncomplex 675635013898 hypothetical protein; Provisional; Region: PRK05409 675635013899 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635013900 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635013901 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 675635013902 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 675635013903 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635013904 carboxyltransferase (CT) interaction site; other site 675635013905 biotinylation site [posttranslational modification]; other site 675635013906 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 675635013907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635013908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635013909 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635013910 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 675635013911 putative active site pocket [active] 675635013912 dimerization interface [polypeptide binding]; other site 675635013913 putative catalytic residue [active] 675635013914 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 675635013915 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635013916 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635013917 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 675635013918 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635013919 carboxyltransferase (CT) interaction site; other site 675635013920 biotinylation site [posttranslational modification]; other site 675635013921 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 675635013922 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 675635013923 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 675635013924 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 675635013925 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 675635013926 putative active site [active] 675635013927 putative catalytic site [active] 675635013928 enoyl-CoA hydratase; Provisional; Region: PRK06688 675635013929 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635013930 substrate binding site [chemical binding]; other site 675635013931 oxyanion hole (OAH) forming residues; other site 675635013932 trimer interface [polypeptide binding]; other site 675635013933 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 675635013934 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 675635013935 acyl-activating enzyme (AAE) consensus motif; other site 675635013936 putative AMP binding site [chemical binding]; other site 675635013937 putative active site [active] 675635013938 putative CoA binding site [chemical binding]; other site 675635013939 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635013940 active site 2 [active] 675635013941 active site 1 [active] 675635013942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635013943 putative substrate translocation pore; other site 675635013944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635013945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635013946 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635013947 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 675635013948 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 675635013949 metal binding site [ion binding]; metal-binding site 675635013950 putative dimer interface [polypeptide binding]; other site 675635013951 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635013952 Catalytic domain of Protein Kinases; Region: PKc; cd00180 675635013953 active site 675635013954 ATP binding site [chemical binding]; other site 675635013955 substrate binding site [chemical binding]; other site 675635013956 activation loop (A-loop); other site 675635013957 purine nucleoside phosphorylase; Provisional; Region: PRK08202 675635013958 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 675635013959 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 675635013960 active site 675635013961 substrate binding site [chemical binding]; other site 675635013962 metal binding site [ion binding]; metal-binding site 675635013963 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 675635013964 active site 675635013965 catalytic triad [active] 675635013966 oxyanion hole [active] 675635013967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635013968 WHG domain; Region: WHG; pfam13305 675635013969 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635013970 active site 675635013971 haloalkane dehalogenase; Provisional; Region: PRK00870 675635013972 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635013973 adenosine deaminase; Provisional; Region: PRK09358 675635013974 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 675635013975 active site 675635013976 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 675635013977 MviN-like protein; Region: MVIN; pfam03023 675635013978 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635013979 hydrophobic ligand binding site; other site 675635013980 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 675635013981 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 675635013982 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 675635013983 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 675635013984 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 675635013985 active site 675635013986 HIGH motif; other site 675635013987 dimer interface [polypeptide binding]; other site 675635013988 KMSKS motif; other site 675635013989 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 675635013990 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 675635013991 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635013992 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635013993 acyl-activating enzyme (AAE) consensus motif; other site 675635013994 AMP binding site [chemical binding]; other site 675635013995 active site 675635013996 CoA binding site [chemical binding]; other site 675635013997 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 675635013998 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 675635013999 FO synthase; Reviewed; Region: fbiC; PRK09234 675635014000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635014001 FeS/SAM binding site; other site 675635014002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635014003 FeS/SAM binding site; other site 675635014004 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 675635014005 putative deacylase active site [active] 675635014006 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 675635014007 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 675635014008 active site 675635014009 ATP binding site [chemical binding]; other site 675635014010 substrate binding site [chemical binding]; other site 675635014011 activation loop (A-loop); other site 675635014012 Septum formation; Region: Septum_form; pfam13845 675635014013 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 675635014014 putative catalytic site [active] 675635014015 putative metal binding site [ion binding]; other site 675635014016 putative phosphate binding site [ion binding]; other site 675635014017 isocitrate dehydrogenase; Validated; Region: PRK08299 675635014018 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 675635014019 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 675635014020 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 675635014021 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Region: THF_DHG_CYH_C; pfam02882 675635014022 NAD(P) binding pocket [chemical binding]; other site 675635014023 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 675635014024 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 675635014025 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 675635014026 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 675635014027 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 675635014028 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 675635014029 active site 675635014030 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 675635014031 generic binding surface I; other site 675635014032 generic binding surface II; other site 675635014033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635014034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635014035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635014036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635014037 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635014038 catalytic residues [active] 675635014039 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 675635014040 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 675635014041 DNA binding residues [nucleotide binding] 675635014042 putative dimer interface [polypeptide binding]; other site 675635014043 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 675635014044 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635014045 phosphate binding site [ion binding]; other site 675635014046 Y-family of DNA polymerases; Region: PolY; cl12025 675635014047 active site 675635014048 DNA binding site [nucleotide binding] 675635014049 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635014050 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 675635014051 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 675635014052 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 675635014053 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 675635014054 purine monophosphate binding site [chemical binding]; other site 675635014055 dimer interface [polypeptide binding]; other site 675635014056 putative catalytic residues [active] 675635014057 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 675635014058 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 675635014059 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 675635014060 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 675635014061 active site 675635014062 substrate binding site [chemical binding]; other site 675635014063 cosubstrate binding site; other site 675635014064 catalytic site [active] 675635014065 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 675635014066 CoA binding domain; Region: CoA_binding; smart00881 675635014067 CoA-ligase; Region: Ligase_CoA; pfam00549 675635014068 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 675635014069 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 675635014070 CoA-ligase; Region: Ligase_CoA; pfam00549 675635014071 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 675635014072 Lipase (class 2); Region: Lipase_2; pfam01674 675635014073 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 675635014074 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635014075 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 675635014076 Part of AAA domain; Region: AAA_19; pfam13245 675635014077 Family description; Region: UvrD_C_2; pfam13538 675635014078 Chorismate mutase type II; Region: CM_2; cl00693 675635014079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635014080 Integrase core domain; Region: rve; pfam00665 675635014081 transposase/IS protein; Provisional; Region: PRK09183 675635014082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635014083 Walker A motif; other site 675635014084 ATP binding site [chemical binding]; other site 675635014085 Walker B motif; other site 675635014086 arginine finger; other site 675635014087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635014088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014089 active site 675635014090 phosphorylation site [posttranslational modification] 675635014091 intermolecular recognition site; other site 675635014092 dimerization interface [polypeptide binding]; other site 675635014093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635014094 DNA binding residues [nucleotide binding] 675635014095 dimerization interface [polypeptide binding]; other site 675635014096 PspC domain; Region: PspC; pfam04024 675635014097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635014098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635014099 ATP binding site [chemical binding]; other site 675635014100 Mg2+ binding site [ion binding]; other site 675635014101 G-X-G motif; other site 675635014102 PspC domain; Region: PspC; pfam04024 675635014103 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 675635014104 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 675635014105 FAD binding site [chemical binding]; other site 675635014106 GMP synthase; Reviewed; Region: guaA; PRK00074 675635014107 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 675635014108 AMP/PPi binding site [chemical binding]; other site 675635014109 candidate oxyanion hole; other site 675635014110 catalytic triad [active] 675635014111 potential glutamine specificity residues [chemical binding]; other site 675635014112 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 675635014113 ATP Binding subdomain [chemical binding]; other site 675635014114 Ligand Binding sites [chemical binding]; other site 675635014115 Dimerization subdomain; other site 675635014116 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635014117 hydrophobic ligand binding site; other site 675635014118 Fic/DOC family; Region: Fic; cl00960 675635014119 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 675635014120 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 675635014121 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635014122 phosphate binding site [ion binding]; other site 675635014123 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 675635014124 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635014125 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 675635014126 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 675635014127 active site 675635014128 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 675635014129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635014130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635014131 DNA binding residues [nucleotide binding] 675635014132 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635014133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014134 active site 675635014135 phosphorylation site [posttranslational modification] 675635014136 intermolecular recognition site; other site 675635014137 dimerization interface [polypeptide binding]; other site 675635014138 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635014139 DNA binding residues [nucleotide binding] 675635014140 dimerization interface [polypeptide binding]; other site 675635014141 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635014142 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 675635014143 DNA binding residues [nucleotide binding] 675635014144 B12 binding domain; Region: B12-binding_2; cl03653 675635014145 Transcription factor WhiB; Region: Whib; pfam02467 675635014146 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 675635014147 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 675635014148 ring oligomerisation interface [polypeptide binding]; other site 675635014149 ATP/Mg binding site [chemical binding]; other site 675635014150 stacking interactions; other site 675635014151 hinge regions; other site 675635014152 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 675635014153 oligomerisation interface [polypeptide binding]; other site 675635014154 mobile loop; other site 675635014155 roof hairpin; other site 675635014156 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635014157 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635014158 active site 675635014159 catalytic tetrad [active] 675635014160 UGMP family protein; Validated; Region: PRK09604 675635014161 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 675635014162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635014163 Coenzyme A binding pocket [chemical binding]; other site 675635014164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 675635014165 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 675635014166 Glycoprotease family; Region: Peptidase_M22; pfam00814 675635014167 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 675635014168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 675635014169 motif II; other site 675635014170 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 675635014171 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635014172 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635014173 catalytic site [active] 675635014174 alanine racemase; Reviewed; Region: alr; PRK00053 675635014175 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 675635014176 active site 675635014177 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 675635014178 dimer interface [polypeptide binding]; other site 675635014179 substrate binding site [chemical binding]; other site 675635014180 catalytic residues [active] 675635014181 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 675635014182 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 675635014183 putative substrate binding site [chemical binding]; other site 675635014184 putative ATP binding site [chemical binding]; other site 675635014185 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 675635014186 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 675635014187 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 675635014188 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 675635014189 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 675635014190 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 675635014191 active site 675635014192 substrate binding site [chemical binding]; other site 675635014193 metal binding site [ion binding]; metal-binding site 675635014194 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 675635014195 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 675635014196 23S rRNA interface [nucleotide binding]; other site 675635014197 L3 interface [polypeptide binding]; other site 675635014198 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 675635014199 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 675635014200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635014201 Coenzyme A binding pocket [chemical binding]; other site 675635014202 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 675635014203 Amidase; Region: Amidase; cl11426 675635014204 indole-3-acetamide amidohydrolase; Region: PLN02722 675635014205 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 675635014206 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 675635014207 Amidohydrolase; Region: Amidohydro_4; pfam13147 675635014208 active site 675635014209 oxidase reductase; Provisional; Region: PTZ00273 675635014210 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 675635014211 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 675635014212 Helix-turn-helix; Region: HTH_3; pfam01381 675635014213 sequence-specific DNA binding site [nucleotide binding]; other site 675635014214 salt bridge; other site 675635014215 Cupin domain; Region: Cupin_2; pfam07883 675635014216 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 675635014217 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635014218 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 675635014219 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635014220 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635014221 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 675635014222 Subtilase family; Region: Peptidase_S8; pfam00082 675635014223 active site 675635014224 catalytic residues [active] 675635014225 Protein of unknown function (DUF690); Region: DUF690; cl04939 675635014226 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635014227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014228 active site 675635014229 phosphorylation site [posttranslational modification] 675635014230 intermolecular recognition site; other site 675635014231 dimerization interface [polypeptide binding]; other site 675635014232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635014233 DNA binding residues [nucleotide binding] 675635014234 dimerization interface [polypeptide binding]; other site 675635014235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635014236 Histidine kinase; Region: HisKA_3; pfam07730 675635014237 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 675635014238 Mg2+ binding site [ion binding]; other site 675635014239 G-X-G motif; other site 675635014240 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 675635014241 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 675635014242 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 675635014243 dimerization interface 3.5A [polypeptide binding]; other site 675635014244 active site 675635014245 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 675635014246 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 675635014247 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 675635014248 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 675635014249 alphaNTD homodimer interface [polypeptide binding]; other site 675635014250 alphaNTD - beta interaction site [polypeptide binding]; other site 675635014251 alphaNTD - beta' interaction site [polypeptide binding]; other site 675635014252 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 675635014253 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 675635014254 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 675635014255 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 675635014256 RNA binding surface [nucleotide binding]; other site 675635014257 30S ribosomal protein S11; Validated; Region: PRK05309 675635014258 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 675635014259 30S ribosomal protein S13; Region: bact_S13; TIGR03631 675635014260 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 675635014261 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 675635014262 rRNA binding site [nucleotide binding]; other site 675635014263 predicted 30S ribosome binding site; other site 675635014264 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 675635014265 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 675635014266 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 675635014267 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 675635014268 ligand binding site [chemical binding]; other site 675635014269 NAD(P) binding site [chemical binding]; other site 675635014270 trimer interface B [polypeptide binding]; other site 675635014271 homodimer interface [polypeptide binding]; other site 675635014272 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; pfam01262 675635014273 trimer interface A [polypeptide binding]; other site 675635014274 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 675635014275 active site 675635014276 adenylate kinase; Reviewed; Region: adk; PRK00279 675635014277 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 675635014278 AMP-binding site [chemical binding]; other site 675635014279 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 675635014280 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 675635014281 SecY translocase; Region: SecY; pfam00344 675635014282 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 675635014283 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 675635014284 23S rRNA binding site [nucleotide binding]; other site 675635014285 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 675635014286 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 675635014287 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 675635014288 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 675635014289 5S rRNA interface [nucleotide binding]; other site 675635014290 L27 interface [polypeptide binding]; other site 675635014291 23S rRNA interface [nucleotide binding]; other site 675635014292 L5 interface [polypeptide binding]; other site 675635014293 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 675635014294 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 675635014295 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 675635014296 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 675635014297 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 675635014298 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 675635014299 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 675635014300 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 675635014301 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 675635014302 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 675635014303 RNA binding site [nucleotide binding]; other site 675635014304 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 675635014305 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 675635014306 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 675635014307 23S rRNA interface [nucleotide binding]; other site 675635014308 putative translocon interaction site; other site 675635014309 signal recognition particle (SRP54) interaction site; other site 675635014310 L23 interface [polypeptide binding]; other site 675635014311 trigger factor interaction site; other site 675635014312 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 675635014313 23S rRNA interface [nucleotide binding]; other site 675635014314 5S rRNA interface [nucleotide binding]; other site 675635014315 putative antibiotic binding site [chemical binding]; other site 675635014316 L25 interface [polypeptide binding]; other site 675635014317 L27 interface [polypeptide binding]; other site 675635014318 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 675635014319 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 675635014320 G-X-X-G motif; other site 675635014321 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 675635014322 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 675635014323 protein-rRNA interface [nucleotide binding]; other site 675635014324 putative translocon binding site; other site 675635014325 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 675635014326 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 675635014327 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 675635014328 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 675635014329 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 675635014330 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 675635014331 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 675635014332 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 675635014333 elongation factor Tu; Reviewed; Region: PRK00049 675635014334 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 675635014335 G1 box; other site 675635014336 GEF interaction site [polypeptide binding]; other site 675635014337 GTP/Mg2+ binding site [chemical binding]; other site 675635014338 Switch I region; other site 675635014339 G2 box; other site 675635014340 G3 box; other site 675635014341 Switch II region; other site 675635014342 G4 box; other site 675635014343 G5 box; other site 675635014344 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 675635014345 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 675635014346 Antibiotic Binding Site [chemical binding]; other site 675635014347 elongation factor G; Reviewed; Region: PRK00007 675635014348 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 675635014349 G1 box; other site 675635014350 putative GEF interaction site [polypeptide binding]; other site 675635014351 GTP/Mg2+ binding site [chemical binding]; other site 675635014352 Switch I region; other site 675635014353 G2 box; other site 675635014354 G3 box; other site 675635014355 Switch II region; other site 675635014356 G4 box; other site 675635014357 G5 box; other site 675635014358 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 675635014359 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 675635014360 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 675635014361 30S ribosomal protein S7; Validated; Region: PRK05302 675635014362 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 675635014363 S17 interaction site [polypeptide binding]; other site 675635014364 S8 interaction site; other site 675635014365 16S rRNA interaction site [nucleotide binding]; other site 675635014366 streptomycin interaction site [chemical binding]; other site 675635014367 23S rRNA interaction site [nucleotide binding]; other site 675635014368 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 675635014369 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 675635014370 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 675635014371 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 675635014372 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 675635014373 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 675635014374 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 675635014375 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 675635014376 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 675635014377 DNA binding site [nucleotide binding] 675635014378 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 675635014379 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 675635014380 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 675635014381 RPB12 interaction site [polypeptide binding]; other site 675635014382 RPB1 interaction site [polypeptide binding]; other site 675635014383 RPB10 interaction site [polypeptide binding]; other site 675635014384 RPB11 interaction site [polypeptide binding]; other site 675635014385 RPB3 interaction site [polypeptide binding]; other site 675635014386 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635014387 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 675635014388 acyl-activating enzyme (AAE) consensus motif; other site 675635014389 AMP binding site [chemical binding]; other site 675635014390 active site 675635014391 CoA binding site [chemical binding]; other site 675635014392 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 675635014393 L11 interface [polypeptide binding]; other site 675635014394 putative EF-Tu interaction site [polypeptide binding]; other site 675635014395 putative EF-G interaction site [polypeptide binding]; other site 675635014396 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 675635014397 23S rRNA interface [nucleotide binding]; other site 675635014398 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 675635014399 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 675635014400 mce related protein; Region: MCE; pfam02470 675635014401 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 675635014402 mce related protein; Region: MCE; pfam02470 675635014403 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 675635014404 mce related protein; Region: MCE; pfam02470 675635014405 mce related protein; Region: MCE; pfam02470 675635014406 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 675635014407 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 675635014408 mce related protein; Region: MCE; pfam02470 675635014409 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 675635014410 mce related protein; Region: MCE; pfam02470 675635014411 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 675635014412 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 675635014413 Permease; Region: Permease; pfam02405 675635014414 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 675635014415 Permease; Region: Permease; pfam02405 675635014416 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 675635014417 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 675635014418 Walker A/P-loop; other site 675635014419 ATP binding site [chemical binding]; other site 675635014420 Q-loop/lid; other site 675635014421 ABC transporter signature motif; other site 675635014422 Walker B; other site 675635014423 D-loop; other site 675635014424 H-loop/switch region; other site 675635014425 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 675635014426 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 675635014427 active site 675635014428 diiron metal binding site [ion binding]; other site 675635014429 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 675635014430 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 675635014431 NAD binding site [chemical binding]; other site 675635014432 catalytic Zn binding site [ion binding]; other site 675635014433 substrate binding site [chemical binding]; other site 675635014434 structural Zn binding site [ion binding]; other site 675635014435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635014436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635014437 ATP binding site [chemical binding]; other site 675635014438 Mg2+ binding site [ion binding]; other site 675635014439 G-X-G motif; other site 675635014440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014441 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635014442 active site 675635014443 phosphorylation site [posttranslational modification] 675635014444 intermolecular recognition site; other site 675635014445 dimerization interface [polypeptide binding]; other site 675635014446 SCP-2 sterol transfer family; Region: SCP2; pfam02036 675635014447 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 675635014448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635014449 DNA-binding site [nucleotide binding]; DNA binding site 675635014450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635014451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635014452 homodimer interface [polypeptide binding]; other site 675635014453 catalytic residue [active] 675635014454 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635014455 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635014456 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 675635014457 mRNA/rRNA interface [nucleotide binding]; other site 675635014458 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 675635014459 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 675635014460 23S rRNA interface [nucleotide binding]; other site 675635014461 L7/L12 interface [polypeptide binding]; other site 675635014462 putative thiostrepton binding site; other site 675635014463 L25 interface [polypeptide binding]; other site 675635014464 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 675635014465 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 675635014466 putative homodimer interface [polypeptide binding]; other site 675635014467 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 675635014468 heterodimer interface [polypeptide binding]; other site 675635014469 homodimer interface [polypeptide binding]; other site 675635014470 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 675635014471 aspartate aminotransferase; Provisional; Region: PRK05764 675635014472 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635014473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635014474 homodimer interface [polypeptide binding]; other site 675635014475 catalytic residue [active] 675635014476 Y-family of DNA polymerases; Region: PolY; cl12025 675635014477 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 675635014478 active site 675635014479 catalytic site [active] 675635014480 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 675635014481 active site 675635014482 catalytic site [active] 675635014483 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 675635014484 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 675635014485 AAA ATPase domain; Region: AAA_16; pfam13191 675635014486 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635014487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635014488 DNA binding residues [nucleotide binding] 675635014489 dimerization interface [polypeptide binding]; other site 675635014490 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635014491 Cytochrome P450; Region: p450; cl12078 675635014492 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635014493 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635014494 acyl-activating enzyme (AAE) consensus motif; other site 675635014495 AMP binding site [chemical binding]; other site 675635014496 active site 675635014497 CoA binding site [chemical binding]; other site 675635014498 Putative transcription activator [Transcription]; Region: TenA; COG0819 675635014499 Predicted membrane protein [Function unknown]; Region: COG1950 675635014500 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 675635014501 Beta-lactamase; Region: Beta-lactamase; pfam00144 675635014502 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 675635014503 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 675635014504 nucleophile elbow; other site 675635014505 Helix-turn-helix domain; Region: HTH_38; pfam13936 675635014506 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635014507 Integrase core domain; Region: rve; pfam00665 675635014508 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635014509 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 675635014510 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 675635014511 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635014512 CoenzymeA binding site [chemical binding]; other site 675635014513 subunit interaction site [polypeptide binding]; other site 675635014514 PHB binding site; other site 675635014515 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635014516 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 675635014517 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 675635014518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635014519 non-specific DNA binding site [nucleotide binding]; other site 675635014520 salt bridge; other site 675635014521 sequence-specific DNA binding site [nucleotide binding]; other site 675635014522 Cupin domain; Region: Cupin_2; pfam07883 675635014523 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 675635014524 Domain of unknown function (DUF336); Region: DUF336; cl01249 675635014525 active site 675635014526 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 675635014527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635014528 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 675635014529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635014530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635014531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635014532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635014533 WHG domain; Region: WHG; pfam13305 675635014534 short chain dehydrogenase; Provisional; Region: PRK12937 675635014535 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 675635014536 NADP binding site [chemical binding]; other site 675635014537 homodimer interface [polypeptide binding]; other site 675635014538 active site 675635014539 substrate binding site [chemical binding]; other site 675635014540 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 675635014541 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635014542 DNA binding residues [nucleotide binding] 675635014543 dimer interface [polypeptide binding]; other site 675635014544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635014545 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635014546 active site 675635014547 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635014548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635014549 NAD(P) binding site [chemical binding]; other site 675635014550 active site 675635014551 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 675635014552 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635014553 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 675635014554 acyl-activating enzyme (AAE) consensus motif; other site 675635014555 acyl-activating enzyme (AAE) consensus motif; other site 675635014556 putative AMP binding site [chemical binding]; other site 675635014557 putative active site [active] 675635014558 putative CoA binding site [chemical binding]; other site 675635014559 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 675635014560 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635014561 dimer interface [polypeptide binding]; other site 675635014562 active site 675635014563 classical (c) SDRs; Region: SDR_c; cd05233 675635014564 NAD(P) binding site [chemical binding]; other site 675635014565 active site 675635014566 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635014567 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635014568 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635014569 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635014570 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635014571 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635014572 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 675635014573 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635014574 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635014575 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635014576 acyl-activating enzyme (AAE) consensus motif; other site 675635014577 AMP binding site [chemical binding]; other site 675635014578 active site 675635014579 CoA binding site [chemical binding]; other site 675635014580 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 675635014581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635014582 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635014583 classical (c) SDRs; Region: SDR_c; cd05233 675635014584 NAD(P) binding site [chemical binding]; other site 675635014585 active site 675635014586 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 675635014587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 675635014588 MOSC domain; Region: MOSC; pfam03473 675635014589 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 675635014590 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 675635014591 dimer interface [polypeptide binding]; other site 675635014592 active site 675635014593 heme binding site [chemical binding]; other site 675635014594 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 675635014595 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 675635014596 metal binding site 2 [ion binding]; metal-binding site 675635014597 putative DNA binding helix; other site 675635014598 metal binding site 1 [ion binding]; metal-binding site 675635014599 dimer interface [polypeptide binding]; other site 675635014600 structural Zn2+ binding site [ion binding]; other site 675635014601 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 675635014602 active site 675635014603 catalytic triad [active] 675635014604 oxyanion hole [active] 675635014605 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 675635014606 Transcription factor WhiB; Region: Whib; pfam02467 675635014607 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635014608 Helix-turn-helix domain; Region: HTH_17; pfam12728 675635014609 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635014610 active site 675635014611 catalytic residues [active] 675635014612 DNA binding site [nucleotide binding] 675635014613 Int/Topo IB signature motif; other site 675635014614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 675635014615 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 675635014616 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 675635014617 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635014618 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 675635014619 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635014620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635014621 Bacterial transcriptional activator domain; Region: BTAD; smart01043 675635014622 TIGR03086 family protein; Region: TIGR03086 675635014623 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635014624 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635014625 heat shock protein HtpX; Provisional; Region: PRK03072 675635014626 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635014627 CoenzymeA binding site [chemical binding]; other site 675635014628 subunit interaction site [polypeptide binding]; other site 675635014629 PHB binding site; other site 675635014630 enoyl-CoA hydratase; Provisional; Region: PRK05870 675635014631 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635014632 substrate binding site [chemical binding]; other site 675635014633 oxyanion hole (OAH) forming residues; other site 675635014634 trimer interface [polypeptide binding]; other site 675635014635 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 675635014636 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 675635014637 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 675635014638 dimer interface [polypeptide binding]; other site 675635014639 PYR/PP interface [polypeptide binding]; other site 675635014640 TPP binding site [chemical binding]; other site 675635014641 substrate binding site [chemical binding]; other site 675635014642 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 675635014643 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 675635014644 TPP-binding site [chemical binding]; other site 675635014645 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 675635014646 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 675635014647 ligand binding site [chemical binding]; other site 675635014648 Predicted permeases [General function prediction only]; Region: RarD; COG2962 675635014649 EamA-like transporter family; Region: EamA; cl17759 675635014650 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 675635014651 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 675635014652 substrate binding pocket [chemical binding]; other site 675635014653 chain length determination region; other site 675635014654 substrate-Mg2+ binding site; other site 675635014655 catalytic residues [active] 675635014656 aspartate-rich region 1; other site 675635014657 active site lid residues [active] 675635014658 aspartate-rich region 2; other site 675635014659 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 675635014660 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 675635014661 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 675635014662 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 675635014663 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 675635014664 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 675635014665 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 675635014666 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 675635014667 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 675635014668 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 675635014669 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 675635014670 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 675635014671 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 675635014672 4Fe-4S binding domain; Region: Fer4; pfam00037 675635014673 4Fe-4S binding domain; Region: Fer4; pfam00037 675635014674 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 675635014675 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 675635014676 NADH dehydrogenase subunit G; Validated; Region: PRK07860 675635014677 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635014678 catalytic loop [active] 675635014679 iron binding site [ion binding]; other site 675635014680 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 675635014681 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 675635014682 molybdopterin cofactor binding site; other site 675635014683 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 675635014684 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 675635014685 SLBB domain; Region: SLBB; pfam10531 675635014686 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 675635014687 NADH dehydrogenase subunit E; Validated; Region: PRK07539 675635014688 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 675635014689 putative dimer interface [polypeptide binding]; other site 675635014690 [2Fe-2S] cluster binding site [ion binding]; other site 675635014691 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 675635014692 NADH dehydrogenase subunit D; Validated; Region: PRK06075 675635014693 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 675635014694 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 675635014695 NADH dehydrogenase subunit B; Validated; Region: PRK06411 675635014696 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 675635014697 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 675635014698 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 675635014699 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 675635014700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635014701 S-adenosylmethionine binding site [chemical binding]; other site 675635014702 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 675635014703 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635014704 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 675635014705 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 675635014706 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 675635014707 active site 675635014708 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 675635014709 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 675635014710 AAA ATPase domain; Region: AAA_16; pfam13191 675635014711 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635014712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635014713 DNA binding residues [nucleotide binding] 675635014714 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 675635014715 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 675635014716 MOSC domain; Region: MOSC; pfam03473 675635014717 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 675635014718 lipoyl attachment site [posttranslational modification]; other site 675635014719 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 675635014720 CGNR zinc finger; Region: zf-CGNR; pfam11706 675635014721 Domain of unknown function (DUF427); Region: DUF427; cl00998 675635014722 Domain of unknown function (DUF427); Region: DUF427; pfam04248 675635014723 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635014724 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635014725 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635014726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 675635014727 MOSC domain; Region: MOSC; pfam03473 675635014728 3-alpha domain; Region: 3-alpha; pfam03475 675635014729 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 675635014730 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 675635014731 FAD binding pocket [chemical binding]; other site 675635014732 FAD binding motif [chemical binding]; other site 675635014733 phosphate binding motif [ion binding]; other site 675635014734 beta-alpha-beta structure motif; other site 675635014735 NAD binding pocket [chemical binding]; other site 675635014736 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635014737 catalytic loop [active] 675635014738 iron binding site [ion binding]; other site 675635014739 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635014740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635014741 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635014742 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 675635014743 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 675635014744 dimer interface [polypeptide binding]; other site 675635014745 tetramer interface [polypeptide binding]; other site 675635014746 PYR/PP interface [polypeptide binding]; other site 675635014747 TPP binding site [chemical binding]; other site 675635014748 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 675635014749 TPP-binding site [chemical binding]; other site 675635014750 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 675635014751 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635014752 inhibitor-cofactor binding pocket; inhibition site 675635014753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635014754 catalytic residue [active] 675635014755 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 675635014756 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 675635014757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635014758 D-loop; other site 675635014759 H-loop/switch region; other site 675635014760 ABC transporter; Region: ABC_tran_2; pfam12848 675635014761 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 675635014762 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 675635014763 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635014764 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635014765 active site 675635014766 catalytic tetrad [active] 675635014767 Protein of unknown function (DUF998); Region: DUF998; pfam06197 675635014768 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635014769 FAD binding domain; Region: FAD_binding_4; pfam01565 675635014770 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 675635014771 ANTAR domain; Region: ANTAR; pfam03861 675635014772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635014773 Coenzyme A binding pocket [chemical binding]; other site 675635014774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635014775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635014776 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 675635014777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635014778 substrate binding site [chemical binding]; other site 675635014779 oxyanion hole (OAH) forming residues; other site 675635014780 trimer interface [polypeptide binding]; other site 675635014781 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 675635014782 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 675635014783 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 675635014784 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 675635014785 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 675635014786 ATP binding site [chemical binding]; other site 675635014787 putative Mg++ binding site [ion binding]; other site 675635014788 helicase superfamily c-terminal domain; Region: HELICc; smart00490 675635014789 Helicase associated domain (HA2); Region: HA2; pfam04408 675635014790 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 675635014791 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635014792 acyl-activating enzyme (AAE) consensus motif; other site 675635014793 AMP binding site [chemical binding]; other site 675635014794 active site 675635014795 CoA binding site [chemical binding]; other site 675635014796 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 675635014797 UbiA prenyltransferase family; Region: UbiA; pfam01040 675635014798 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 675635014799 DNA binding residues [nucleotide binding] 675635014800 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 675635014801 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 675635014802 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 675635014803 ResB-like family; Region: ResB; pfam05140 675635014804 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 675635014805 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 675635014806 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 675635014807 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 675635014808 catalytic residues [active] 675635014809 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635014810 catalytic core [active] 675635014811 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 675635014812 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635014813 inhibitor-cofactor binding pocket; inhibition site 675635014814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635014815 catalytic residue [active] 675635014816 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 675635014817 RDD family; Region: RDD; pfam06271 675635014818 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 675635014819 dimer interface [polypeptide binding]; other site 675635014820 active site 675635014821 Schiff base residues; other site 675635014822 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 675635014823 homodimer interface [polypeptide binding]; other site 675635014824 active site 675635014825 SAM binding site [chemical binding]; other site 675635014826 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 675635014827 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 675635014828 active site 675635014829 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 675635014830 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 675635014831 domain interfaces; other site 675635014832 active site 675635014833 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 675635014834 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 675635014835 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 675635014836 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 675635014837 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 675635014838 CoA binding domain; Region: CoA_binding; smart00881 675635014839 Fasciclin domain; Region: Fasciclin; pfam02469 675635014840 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 675635014841 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 675635014842 Moco binding site; other site 675635014843 metal coordination site [ion binding]; other site 675635014844 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 675635014845 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635014846 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635014847 acyl-activating enzyme (AAE) consensus motif; other site 675635014848 AMP binding site [chemical binding]; other site 675635014849 active site 675635014850 CoA binding site [chemical binding]; other site 675635014851 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 675635014852 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635014853 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635014854 DNA binding residues [nucleotide binding] 675635014855 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 675635014856 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 675635014857 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 675635014858 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 675635014859 putative acyl-acceptor binding pocket; other site 675635014860 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 675635014861 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635014862 putative NAD(P) binding site [chemical binding]; other site 675635014863 active site 675635014864 putative substrate binding site [chemical binding]; other site 675635014865 DNA binding domain, excisionase family; Region: excise; TIGR01764 675635014866 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 675635014867 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 675635014868 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 675635014869 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 675635014870 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635014871 CoenzymeA binding site [chemical binding]; other site 675635014872 subunit interaction site [polypeptide binding]; other site 675635014873 PHB binding site; other site 675635014874 Proline dehydrogenase; Region: Pro_dh; cl03282 675635014875 Proline dehydrogenase; Region: Pro_dh; cl03282 675635014876 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635014877 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 675635014878 exopolyphosphatase; Region: exo_poly_only; TIGR03706 675635014879 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 675635014880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635014881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014882 active site 675635014883 phosphorylation site [posttranslational modification] 675635014884 intermolecular recognition site; other site 675635014885 dimerization interface [polypeptide binding]; other site 675635014886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635014887 DNA binding site [nucleotide binding] 675635014888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635014889 dimer interface [polypeptide binding]; other site 675635014890 phosphorylation site [posttranslational modification] 675635014891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635014892 ATP binding site [chemical binding]; other site 675635014893 Mg2+ binding site [ion binding]; other site 675635014894 G-X-G motif; other site 675635014895 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 675635014896 catalytic core [active] 675635014897 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 675635014898 MarR family; Region: MarR_2; pfam12802 675635014899 MarR family; Region: MarR_2; cl17246 675635014900 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635014901 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635014902 active site 675635014903 metal binding site [ion binding]; metal-binding site 675635014904 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 675635014905 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 675635014906 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 675635014907 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 675635014908 putative ADP-binding pocket [chemical binding]; other site 675635014909 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 675635014910 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 675635014911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 675635014912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635014913 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 675635014914 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 675635014915 DNA-binding site [nucleotide binding]; DNA binding site 675635014916 RNA-binding motif; other site 675635014917 AMP-binding domain protein; Validated; Region: PRK08315 675635014918 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635014919 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 675635014920 acyl-activating enzyme (AAE) consensus motif; other site 675635014921 putative AMP binding site [chemical binding]; other site 675635014922 putative active site [active] 675635014923 putative CoA binding site [chemical binding]; other site 675635014924 seryl-tRNA synthetase; Provisional; Region: PRK05431 675635014925 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 675635014926 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 675635014927 dimer interface [polypeptide binding]; other site 675635014928 active site 675635014929 motif 1; other site 675635014930 motif 2; other site 675635014931 motif 3; other site 675635014932 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 675635014933 calcium binding site 2 [ion binding]; other site 675635014934 active site 675635014935 catalytic triad [active] 675635014936 calcium binding site 1 [ion binding]; other site 675635014937 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 675635014938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635014939 Walker A/P-loop; other site 675635014940 ATP binding site [chemical binding]; other site 675635014941 Q-loop/lid; other site 675635014942 ABC transporter signature motif; other site 675635014943 Walker B; other site 675635014944 D-loop; other site 675635014945 H-loop/switch region; other site 675635014946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635014947 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 675635014948 putative PBP binding loops; other site 675635014949 ABC-ATPase subunit interface; other site 675635014950 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 675635014951 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 675635014952 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635014953 DNA binding residues [nucleotide binding] 675635014954 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 675635014955 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635014956 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635014957 active site 675635014958 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 675635014959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635014960 FeS/SAM binding site; other site 675635014961 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 675635014962 Ubiquitin-like proteins; Region: UBQ; cl00155 675635014963 charged pocket; other site 675635014964 hydrophobic patch; other site 675635014965 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 675635014966 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 675635014967 cleavage site 675635014968 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 675635014969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635014970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635014971 active site 675635014972 phosphorylation site [posttranslational modification] 675635014973 intermolecular recognition site; other site 675635014974 dimerization interface [polypeptide binding]; other site 675635014975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635014976 DNA binding site [nucleotide binding] 675635014977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635014978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635014979 dimer interface [polypeptide binding]; other site 675635014980 phosphorylation site [posttranslational modification] 675635014981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635014982 ATP binding site [chemical binding]; other site 675635014983 Mg2+ binding site [ion binding]; other site 675635014984 G-X-G motif; other site 675635014985 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 675635014986 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 675635014987 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 675635014988 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635014989 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 675635014990 putative hydrophobic ligand binding site [chemical binding]; other site 675635014991 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635014992 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 675635014993 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635014994 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635014995 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635014996 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635014997 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 675635014998 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635014999 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 675635015000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 675635015001 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 675635015002 Creatinine amidohydrolase; Region: Creatininase; cl00618 675635015003 mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996 675635015004 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635015005 phosphate binding site [ion binding]; other site 675635015006 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 675635015007 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635015008 phosphate binding site [ion binding]; other site 675635015009 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 675635015010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 675635015011 FeS/SAM binding site; other site 675635015012 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 675635015013 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 675635015014 Protein of unknown function (DUF952); Region: DUF952; cl01393 675635015015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015016 NAD(P) binding site [chemical binding]; other site 675635015017 active site 675635015018 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 675635015019 classical (c) SDRs; Region: SDR_c; cd05233 675635015020 NAD(P) binding site [chemical binding]; other site 675635015021 active site 675635015022 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 675635015023 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 675635015024 phosphate binding site [ion binding]; other site 675635015025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635015026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635015027 ATP binding site [chemical binding]; other site 675635015028 Mg2+ binding site [ion binding]; other site 675635015029 G-X-G motif; other site 675635015030 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635015031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015032 active site 675635015033 phosphorylation site [posttranslational modification] 675635015034 intermolecular recognition site; other site 675635015035 dimerization interface [polypeptide binding]; other site 675635015036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015037 DNA binding residues [nucleotide binding] 675635015038 dimerization interface [polypeptide binding]; other site 675635015039 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 675635015040 active site 675635015041 catalytic residues [active] 675635015042 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 675635015043 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 675635015044 NodB motif; other site 675635015045 active site 675635015046 catalytic site [active] 675635015047 metal binding site [ion binding]; metal-binding site 675635015048 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635015049 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 675635015050 DXD motif; other site 675635015051 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 675635015052 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635015053 FAD binding domain; Region: FAD_binding_4; pfam01565 675635015054 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 675635015055 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635015056 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635015057 catalytic loop [active] 675635015058 iron binding site [ion binding]; other site 675635015059 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635015060 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635015061 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635015062 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635015063 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 675635015064 dimer interface [polypeptide binding]; other site 675635015065 substrate binding site [chemical binding]; other site 675635015066 ATP binding site [chemical binding]; other site 675635015067 Domain of unknown function (DUF385); Region: DUF385; pfam04075 675635015068 FtsX-like permease family; Region: FtsX; pfam02687 675635015069 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 675635015070 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 675635015071 Walker A/P-loop; other site 675635015072 ATP binding site [chemical binding]; other site 675635015073 Q-loop/lid; other site 675635015074 ABC transporter signature motif; other site 675635015075 Walker B; other site 675635015076 D-loop; other site 675635015077 H-loop/switch region; other site 675635015078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635015079 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 675635015080 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635015081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015082 active site 675635015083 phosphorylation site [posttranslational modification] 675635015084 intermolecular recognition site; other site 675635015085 dimerization interface [polypeptide binding]; other site 675635015086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015087 DNA binding residues [nucleotide binding] 675635015088 dimerization interface [polypeptide binding]; other site 675635015089 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 675635015090 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 675635015091 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 675635015092 active site 675635015093 catalytic residues [active] 675635015094 metal binding site [ion binding]; metal-binding site 675635015095 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 675635015096 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 675635015097 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 675635015098 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 675635015099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015100 Walker A motif; other site 675635015101 ATP binding site [chemical binding]; other site 675635015102 Walker B motif; other site 675635015103 arginine finger; other site 675635015104 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 675635015105 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 675635015106 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 675635015107 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 675635015108 dimer interface [polypeptide binding]; other site 675635015109 putative functional site; other site 675635015110 putative MPT binding site; other site 675635015111 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 675635015112 DNA-binding site [nucleotide binding]; DNA binding site 675635015113 RNA-binding motif; other site 675635015114 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 675635015115 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 675635015116 ring oligomerisation interface [polypeptide binding]; other site 675635015117 ATP/Mg binding site [chemical binding]; other site 675635015118 stacking interactions; other site 675635015119 hinge regions; other site 675635015120 HTH domain; Region: HTH_11; pfam08279 675635015121 WYL domain; Region: WYL; pfam13280 675635015122 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635015123 TIGR03086 family protein; Region: TIGR03086 675635015124 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 675635015125 PspC domain; Region: PspC; pfam04024 675635015126 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 675635015127 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 675635015128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635015129 ATP binding site [chemical binding]; other site 675635015130 putative Mg++ binding site [ion binding]; other site 675635015131 nucleotide binding region [chemical binding]; other site 675635015132 helicase superfamily c-terminal domain; Region: HELICc; smart00490 675635015133 ATP-binding site [chemical binding]; other site 675635015134 Nitrate and nitrite sensing; Region: NIT; pfam08376 675635015135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635015136 ATP binding site [chemical binding]; other site 675635015137 Mg2+ binding site [ion binding]; other site 675635015138 G-X-G motif; other site 675635015139 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 675635015140 Protein of unknown function (DUF742); Region: DUF742; pfam05331 675635015141 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 675635015142 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 675635015143 G2 box; other site 675635015144 Switch I region; other site 675635015145 G3 box; other site 675635015146 Switch II region; other site 675635015147 GTP/Mg2+ binding site [chemical binding]; other site 675635015148 G4 box; other site 675635015149 G5 box; other site 675635015150 AAA domain; Region: AAA_33; pfam13671 675635015151 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 675635015152 active site 675635015153 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 675635015154 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 675635015155 metal-binding site 675635015156 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 675635015157 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 675635015158 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 675635015159 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 675635015160 trimer interface [polypeptide binding]; other site 675635015161 dimer interface [polypeptide binding]; other site 675635015162 putative active site [active] 675635015163 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 675635015164 MPT binding site; other site 675635015165 trimer interface [polypeptide binding]; other site 675635015166 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 675635015167 MoaE homodimer interface [polypeptide binding]; other site 675635015168 MoaD interaction [polypeptide binding]; other site 675635015169 active site residues [active] 675635015170 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 675635015171 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 675635015172 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635015173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015174 Walker A motif; other site 675635015175 ATP binding site [chemical binding]; other site 675635015176 Walker B motif; other site 675635015177 arginine finger; other site 675635015178 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 675635015179 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 675635015180 metal ion-dependent adhesion site (MIDAS); other site 675635015181 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 675635015182 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 675635015183 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 675635015184 XdhC Rossmann domain; Region: XdhC_C; pfam13478 675635015185 Sporulation and spore germination; Region: Germane; smart00909 675635015186 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 675635015187 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 675635015188 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 675635015189 trimer interface [polypeptide binding]; other site 675635015190 putative metal binding site [ion binding]; other site 675635015191 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 675635015192 ThiS interaction site; other site 675635015193 putative active site [active] 675635015194 tetramer interface [polypeptide binding]; other site 675635015195 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 675635015196 thiS-thiF/thiG interaction site; other site 675635015197 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 675635015198 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 675635015199 active site 675635015200 thiamine phosphate binding site [chemical binding]; other site 675635015201 pyrophosphate binding site [ion binding]; other site 675635015202 CUT domain; Region: CUT; pfam02376 675635015203 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 675635015204 Helix-turn-helix domain; Region: HTH_17; pfam12728 675635015205 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 675635015206 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635015207 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 675635015208 Phage Terminase; Region: Terminase_1; pfam03354 675635015209 Protein of unknown function (DUF935); Region: DUF935; pfam06074 675635015210 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 675635015211 oligomer interface [polypeptide binding]; other site 675635015212 active site residues [active] 675635015213 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 675635015214 oligomerization interface [polypeptide binding]; other site 675635015215 LTXXQ motif family protein; Region: LTXXQ; pfam07813 675635015216 CHAP domain; Region: CHAP; cl17642 675635015217 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635015218 DNA binding residues [nucleotide binding] 675635015219 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635015220 active site 675635015221 catalytic residues [active] 675635015222 DNA binding site [nucleotide binding] 675635015223 Int/Topo IB signature motif; other site 675635015224 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 675635015225 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 675635015226 active site 675635015227 catalytic triad [active] 675635015228 oxyanion hole [active] 675635015229 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 675635015230 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 675635015231 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 675635015232 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635015233 inhibitor-cofactor binding pocket; inhibition site 675635015234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635015235 catalytic residue [active] 675635015236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635015237 Coenzyme A binding pocket [chemical binding]; other site 675635015238 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635015239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635015240 hypothetical protein; Provisional; Region: PRK11770 675635015241 Domain of unknown function (DUF307); Region: DUF307; pfam03733 675635015242 Domain of unknown function (DUF307); Region: DUF307; pfam03733 675635015243 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 675635015244 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 675635015245 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 675635015246 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 675635015247 Domain of unknown function (DUF427); Region: DUF427; pfam04248 675635015248 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 675635015249 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 675635015250 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635015251 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635015252 active site 675635015253 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635015254 non-prolyl cis peptide bond; other site 675635015255 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635015256 Predicted flavoprotein [General function prediction only]; Region: COG0431 675635015257 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 675635015258 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635015259 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635015260 putative NAD(P) binding site [chemical binding]; other site 675635015261 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 675635015262 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 675635015263 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 675635015264 Helix-turn-helix domain; Region: HTH_38; pfam13936 675635015265 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635015266 Integrase core domain; Region: rve; pfam00665 675635015267 Putative zinc-finger; Region: zf-HC2; pfam13490 675635015268 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 675635015269 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635015270 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635015271 DNA binding residues [nucleotide binding] 675635015272 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 675635015273 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 675635015274 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 675635015275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635015276 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 675635015277 DNA binding site [nucleotide binding] 675635015278 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635015279 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 675635015280 active site 675635015281 nucleotide-binding site [chemical binding]; other site 675635015282 metal-binding site [ion binding] 675635015283 Integral membrane protein TerC family; Region: TerC; cl10468 675635015284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635015285 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 675635015286 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635015287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635015288 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635015289 Predicted esterase [General function prediction only]; Region: COG0400 675635015290 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 675635015291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635015292 DNA-binding site [nucleotide binding]; DNA binding site 675635015293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635015294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635015295 homodimer interface [polypeptide binding]; other site 675635015296 catalytic residue [active] 675635015297 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 675635015298 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635015299 hypothetical protein; Provisional; Region: PRK08317 675635015300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635015301 S-adenosylmethionine binding site [chemical binding]; other site 675635015302 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635015303 Amidase; Region: Amidase; cl11426 675635015304 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635015305 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 675635015306 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 675635015307 Uncharacterized conserved protein [Function unknown]; Region: COG2128 675635015308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635015309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635015310 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635015311 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 675635015312 catalytic Zn binding site [ion binding]; other site 675635015313 structural Zn binding site [ion binding]; other site 675635015314 tetramer interface [polypeptide binding]; other site 675635015315 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 675635015316 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 675635015317 D-pathway; other site 675635015318 Putative ubiquinol binding site [chemical binding]; other site 675635015319 Low-spin heme (heme b) binding site [chemical binding]; other site 675635015320 Putative water exit pathway; other site 675635015321 Binuclear center (heme o3/CuB) [ion binding]; other site 675635015322 K-pathway; other site 675635015323 Putative proton exit pathway; other site 675635015324 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 675635015325 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 675635015326 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 675635015327 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635015328 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 675635015329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 675635015330 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 675635015331 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 675635015332 FMN binding site [chemical binding]; other site 675635015333 substrate binding site [chemical binding]; other site 675635015334 putative catalytic residue [active] 675635015335 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 675635015336 putative hydrophobic ligand binding site [chemical binding]; other site 675635015337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635015338 dimerization interface [polypeptide binding]; other site 675635015339 putative DNA binding site [nucleotide binding]; other site 675635015340 putative Zn2+ binding site [ion binding]; other site 675635015341 RibD C-terminal domain; Region: RibD_C; cl17279 675635015342 Dehydratase family; Region: ILVD_EDD; cl00340 675635015343 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 675635015344 heme binding pocket [chemical binding]; other site 675635015345 heme ligand [chemical binding]; other site 675635015346 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635015347 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 675635015348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635015349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635015350 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635015351 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635015352 active site 675635015353 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635015354 HTH domain; Region: HTH_11; pfam08279 675635015355 WYL domain; Region: WYL; pfam13280 675635015356 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635015357 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635015358 Amidohydrolase; Region: Amidohydro_4; pfam13147 675635015359 active site 675635015360 AAA ATPase domain; Region: AAA_16; pfam13191 675635015361 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635015363 DNA binding residues [nucleotide binding] 675635015364 dimerization interface [polypeptide binding]; other site 675635015365 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635015366 Cytochrome P450; Region: p450; pfam00067 675635015367 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 675635015368 Flavodoxin; Region: Flavodoxin_1; pfam00258 675635015369 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 675635015370 FAD binding pocket [chemical binding]; other site 675635015371 FAD binding motif [chemical binding]; other site 675635015372 catalytic residues [active] 675635015373 NAD binding pocket [chemical binding]; other site 675635015374 phosphate binding motif [ion binding]; other site 675635015375 beta-alpha-beta structure motif; other site 675635015376 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635015377 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 675635015378 [2Fe-2S] cluster binding site [ion binding]; other site 675635015379 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635015380 hydrophobic ligand binding site; other site 675635015381 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 675635015382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635015383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635015384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635015385 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635015386 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635015387 Right handed beta helix region; Region: Beta_helix; pfam13229 675635015388 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 675635015389 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 675635015390 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635015391 Cytochrome P450; Region: p450; cl12078 675635015392 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 675635015393 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 675635015394 inhibitor-cofactor binding pocket; inhibition site 675635015395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635015396 catalytic residue [active] 675635015397 Cupin domain; Region: Cupin_2; pfam07883 675635015398 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635015399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635015400 DNA-binding site [nucleotide binding]; DNA binding site 675635015401 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 675635015402 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 675635015403 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635015404 acyl-activating enzyme (AAE) consensus motif; other site 675635015405 AMP binding site [chemical binding]; other site 675635015406 active site 675635015407 CoA binding site [chemical binding]; other site 675635015408 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635015409 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635015410 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635015411 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 675635015412 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 675635015413 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635015414 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635015415 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635015416 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635015417 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635015418 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 675635015419 dimer interface [polypeptide binding]; other site 675635015420 active site 675635015421 feruloyl-CoA synthase; Reviewed; Region: PRK08180 675635015422 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635015423 acyl-activating enzyme (AAE) consensus motif; other site 675635015424 AMP binding site [chemical binding]; other site 675635015425 active site 675635015426 CoA binding site [chemical binding]; other site 675635015427 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 675635015428 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 675635015429 NodB motif; other site 675635015430 active site 675635015431 catalytic site [active] 675635015432 metal binding site [ion binding]; metal-binding site 675635015433 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 675635015434 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 675635015435 Moco binding site; other site 675635015436 metal coordination site [ion binding]; other site 675635015437 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 675635015438 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 675635015439 FAD binding pocket [chemical binding]; other site 675635015440 conserved FAD binding motif [chemical binding]; other site 675635015441 phosphate binding motif [ion binding]; other site 675635015442 beta-alpha-beta structure motif; other site 675635015443 NAD binding pocket [chemical binding]; other site 675635015444 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 675635015445 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 675635015446 substrate binding pocket [chemical binding]; other site 675635015447 catalytic triad [active] 675635015448 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 675635015449 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 675635015450 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 675635015451 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 675635015452 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 675635015453 Ecdysteroid kinase; Region: EcKinase; cl17738 675635015454 Phosphotransferase enzyme family; Region: APH; pfam01636 675635015455 Protein of unknown function (DUF664); Region: DUF664; pfam04978 675635015456 DinB superfamily; Region: DinB_2; pfam12867 675635015457 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 675635015458 Beta-lactamase; Region: Beta-lactamase; pfam00144 675635015459 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635015460 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635015461 catalytic loop [active] 675635015462 iron binding site [ion binding]; other site 675635015463 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635015464 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 675635015465 putative hydrophobic ligand binding site [chemical binding]; other site 675635015466 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635015467 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 675635015468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635015469 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635015470 substrate binding site [chemical binding]; other site 675635015471 oxyanion hole (OAH) forming residues; other site 675635015472 trimer interface [polypeptide binding]; other site 675635015473 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635015474 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635015475 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635015476 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635015477 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635015478 acyl-activating enzyme (AAE) consensus motif; other site 675635015479 AMP binding site [chemical binding]; other site 675635015480 active site 675635015481 CoA binding site [chemical binding]; other site 675635015482 Predicted transcriptional regulators [Transcription]; Region: COG1695 675635015483 Transcriptional regulator PadR-like family; Region: PadR; cl17335 675635015484 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 675635015485 putative catalytic residues [active] 675635015486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635015487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635015488 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 675635015489 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 675635015490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015491 NAD(P) binding site [chemical binding]; other site 675635015492 active site 675635015493 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 675635015494 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 675635015495 Ligand binding site; other site 675635015496 Putative Catalytic site; other site 675635015497 DXD motif; other site 675635015498 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; pfam09837 675635015499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 675635015500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635015501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635015502 dimer interface [polypeptide binding]; other site 675635015503 phosphorylation site [posttranslational modification] 675635015504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635015505 ATP binding site [chemical binding]; other site 675635015506 Mg2+ binding site [ion binding]; other site 675635015507 G-X-G motif; other site 675635015508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635015509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015510 active site 675635015511 phosphorylation site [posttranslational modification] 675635015512 intermolecular recognition site; other site 675635015513 dimerization interface [polypeptide binding]; other site 675635015514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635015515 DNA binding site [nucleotide binding] 675635015516 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 675635015517 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 675635015518 Moco binding site; other site 675635015519 metal coordination site [ion binding]; other site 675635015520 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635015521 Amidase; Region: Amidase; pfam01425 675635015522 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 675635015523 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635015524 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635015525 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635015526 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635015527 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 675635015528 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635015529 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 675635015530 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635015531 dimerization interface [polypeptide binding]; other site 675635015532 putative DNA binding site [nucleotide binding]; other site 675635015533 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635015534 putative Zn2+ binding site [ion binding]; other site 675635015535 Winged helix-turn helix; Region: HTH_29; pfam13551 675635015536 Homeodomain-like domain; Region: HTH_32; pfam13565 675635015537 DDE superfamily endonuclease; Region: DDE_3; pfam13358 675635015538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 675635015539 Ferredoxin [Energy production and conversion]; Region: COG1146 675635015540 4Fe-4S binding domain; Region: Fer4; pfam00037 675635015541 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 675635015542 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 675635015543 Walker A/P-loop; other site 675635015544 ATP binding site [chemical binding]; other site 675635015545 Q-loop/lid; other site 675635015546 ABC transporter signature motif; other site 675635015547 Walker B; other site 675635015548 D-loop; other site 675635015549 H-loop/switch region; other site 675635015550 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 675635015551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635015552 putative PBP binding loops; other site 675635015553 dimer interface [polypeptide binding]; other site 675635015554 ABC-ATPase subunit interface; other site 675635015555 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 675635015556 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 675635015557 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 675635015558 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635015559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635015560 DNA-binding site [nucleotide binding]; DNA binding site 675635015561 UTRA domain; Region: UTRA; pfam07702 675635015562 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 675635015563 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 675635015564 hydrophobic ligand binding site; other site 675635015565 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 675635015566 Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; Region: KR; cl00100 675635015567 Predicted transcriptional regulators [Transcription]; Region: COG1733 675635015568 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 675635015569 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 675635015570 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635015571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635015572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635015573 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 675635015574 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 675635015575 active site 675635015576 catalytic tetrad [active] 675635015577 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 675635015578 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 675635015579 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 675635015580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 675635015581 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 675635015582 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635015583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635015584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635015585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635015586 putative substrate translocation pore; other site 675635015587 Peptidase family M48; Region: Peptidase_M48; cl12018 675635015588 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 675635015589 Short C-terminal domain; Region: SHOCT; pfam09851 675635015590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635015591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635015592 DNA binding residues [nucleotide binding] 675635015593 amidase; Provisional; Region: PRK07869 675635015594 Amidase; Region: Amidase; cl11426 675635015595 TIGR03086 family protein; Region: TIGR03086 675635015596 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 675635015597 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 675635015598 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 675635015599 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 675635015600 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 675635015601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015602 NAD(P) binding site [chemical binding]; other site 675635015603 active site 675635015604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 675635015605 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635015606 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 675635015607 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635015608 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 675635015609 putative ligand binding site [chemical binding]; other site 675635015610 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 675635015611 MarR family; Region: MarR; pfam01047 675635015612 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 675635015613 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 675635015614 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 675635015615 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 675635015616 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 675635015617 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 675635015618 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 675635015619 Cupin domain; Region: Cupin_2; pfam07883 675635015620 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 675635015621 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635015622 putative DNA binding site [nucleotide binding]; other site 675635015623 putative Zn2+ binding site [ion binding]; other site 675635015624 AsnC family; Region: AsnC_trans_reg; pfam01037 675635015625 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 675635015626 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635015627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635015628 homodimer interface [polypeptide binding]; other site 675635015629 catalytic residue [active] 675635015630 aspartate aminotransferase; Provisional; Region: PRK05764 675635015631 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635015632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635015633 homodimer interface [polypeptide binding]; other site 675635015634 catalytic residue [active] 675635015635 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635015636 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 675635015637 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635015638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635015639 dimer interface [polypeptide binding]; other site 675635015640 conserved gate region; other site 675635015641 putative PBP binding loops; other site 675635015642 ABC-ATPase subunit interface; other site 675635015643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635015644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635015645 dimer interface [polypeptide binding]; other site 675635015646 conserved gate region; other site 675635015647 putative PBP binding loops; other site 675635015648 ABC-ATPase subunit interface; other site 675635015649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635015650 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635015651 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635015652 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635015653 active site 675635015654 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635015655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635015656 Walker A/P-loop; other site 675635015657 ATP binding site [chemical binding]; other site 675635015658 Q-loop/lid; other site 675635015659 ABC transporter signature motif; other site 675635015660 Walker B; other site 675635015661 D-loop; other site 675635015662 H-loop/switch region; other site 675635015663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635015664 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 675635015665 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635015666 Walker A/P-loop; other site 675635015667 ATP binding site [chemical binding]; other site 675635015668 Q-loop/lid; other site 675635015669 ABC transporter signature motif; other site 675635015670 Walker B; other site 675635015671 D-loop; other site 675635015672 H-loop/switch region; other site 675635015673 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 675635015674 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635015675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015676 active site 675635015677 phosphorylation site [posttranslational modification] 675635015678 intermolecular recognition site; other site 675635015679 dimerization interface [polypeptide binding]; other site 675635015680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635015681 DNA binding site [nucleotide binding] 675635015682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635015683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635015684 dimer interface [polypeptide binding]; other site 675635015685 phosphorylation site [posttranslational modification] 675635015686 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 675635015687 Mg2+ binding site [ion binding]; other site 675635015688 G-X-G motif; other site 675635015689 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 675635015690 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 675635015691 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 675635015692 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 675635015693 putative active site pocket [active] 675635015694 putative metal binding site [ion binding]; other site 675635015695 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 675635015696 thiamine pyrophosphate protein; Provisional; Region: PRK08273 675635015697 PYR/PP interface [polypeptide binding]; other site 675635015698 dimer interface [polypeptide binding]; other site 675635015699 tetramer interface [polypeptide binding]; other site 675635015700 TPP binding site [chemical binding]; other site 675635015701 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 675635015702 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 675635015703 TPP-binding site [chemical binding]; other site 675635015704 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635015705 FAD binding domain; Region: FAD_binding_4; pfam01565 675635015706 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 675635015707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635015708 NAD(P) binding site [chemical binding]; other site 675635015709 active site 675635015710 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 675635015711 Response regulator receiver domain; Region: Response_reg; pfam00072 675635015712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635015713 active site 675635015714 phosphorylation site [posttranslational modification] 675635015715 intermolecular recognition site; other site 675635015716 dimerization interface [polypeptide binding]; other site 675635015717 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635015718 SnoaL-like domain; Region: SnoaL_3; pfam13474 675635015719 SnoaL-like domain; Region: SnoaL_2; pfam12680 675635015720 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635015721 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635015722 catalytic site [active] 675635015723 Serine hydrolase (FSH1); Region: FSH1; pfam03959 675635015724 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 675635015725 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 675635015726 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 675635015727 active site 675635015728 metal binding site [ion binding]; metal-binding site 675635015729 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635015730 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 675635015731 Helix-turn-helix domain; Region: HTH_18; pfam12833 675635015732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635015733 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635015734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635015735 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635015736 transposase/IS protein; Provisional; Region: PRK09183 675635015737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015738 Walker A motif; other site 675635015739 ATP binding site [chemical binding]; other site 675635015740 Walker B motif; other site 675635015741 arginine finger; other site 675635015742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635015743 Integrase core domain; Region: rve; pfam00665 675635015744 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 675635015745 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 675635015746 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635015747 active site 675635015748 catalytic residues [active] 675635015749 DNA binding site [nucleotide binding] 675635015750 Int/Topo IB signature motif; other site 675635015751 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635015752 Helix-turn-helix domain; Region: HTH_38; pfam13936 675635015753 Integrase core domain; Region: rve; pfam00665 675635015754 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635015755 MULE transposase domain; Region: MULE; pfam10551 675635015756 amidase; Provisional; Region: PRK07487 675635015757 Amidase; Region: Amidase; cl11426 675635015758 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635015759 TAP-like protein; Region: Abhydrolase_4; pfam08386 675635015760 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 675635015761 SnoaL-like domain; Region: SnoaL_3; pfam13474 675635015762 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 675635015763 active site 675635015764 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 675635015765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635015766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635015767 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635015768 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 675635015769 NAD(P) binding site [chemical binding]; other site 675635015770 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 675635015771 dimerization interface [polypeptide binding]; other site 675635015772 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635015773 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 675635015774 [2Fe-2S] cluster binding site [ion binding]; other site 675635015775 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 675635015776 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 675635015777 dimerization interface [polypeptide binding]; other site 675635015778 putative path to active site cavity [active] 675635015779 diiron center [ion binding]; other site 675635015780 Muconolactone delta-isomerase; Region: MIase; pfam02426 675635015781 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 675635015782 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 675635015783 metal binding site [ion binding]; metal-binding site 675635015784 substrate binding pocket [chemical binding]; other site 675635015785 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 675635015786 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 675635015787 active site 675635015788 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 675635015789 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 675635015790 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 675635015791 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 675635015792 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635015793 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635015794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 675635015795 TIGR03809 family protein; Region: TIGR03809 675635015796 AAA domain; Region: AAA_31; pfam13614 675635015797 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635015798 P-loop; other site 675635015799 Magnesium ion binding site [ion binding]; other site 675635015800 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 675635015801 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 675635015802 active site 675635015803 catalytic residues [active] 675635015804 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635015805 active site 675635015806 catalytic residues [active] 675635015807 DNA binding site [nucleotide binding] 675635015808 Int/Topo IB signature motif; other site 675635015809 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635015810 active site 675635015811 catalytic residues [active] 675635015812 DNA binding site [nucleotide binding] 675635015813 Int/Topo IB signature motif; other site 675635015814 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635015815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635015816 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635015817 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 675635015818 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635015819 active site 675635015820 DNA binding site [nucleotide binding] 675635015821 Int/Topo IB signature motif; other site 675635015822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635015823 DNA-binding site [nucleotide binding]; DNA binding site 675635015824 ABC-2 type transporter; Region: ABC2_membrane; cl17235 675635015825 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 675635015826 Uncharacterized conserved protein [Function unknown]; Region: COG2966 675635015827 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 675635015828 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 675635015829 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 675635015830 active site 675635015831 homotetramer interface [polypeptide binding]; other site 675635015832 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 675635015833 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 675635015834 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635015835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635015836 DNA binding site [nucleotide binding] 675635015837 domain linker motif; other site 675635015838 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 675635015839 putative dimerization interface [polypeptide binding]; other site 675635015840 putative ligand binding site [chemical binding]; other site 675635015841 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 675635015842 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 675635015843 intersubunit interface [polypeptide binding]; other site 675635015844 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 675635015845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635015846 Walker A/P-loop; other site 675635015847 ATP binding site [chemical binding]; other site 675635015848 Q-loop/lid; other site 675635015849 ABC transporter signature motif; other site 675635015850 Walker B; other site 675635015851 D-loop; other site 675635015852 H-loop/switch region; other site 675635015853 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 675635015854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 675635015855 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 675635015856 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 675635015857 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 675635015858 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 675635015859 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635015860 active site 675635015861 HIGH motif; other site 675635015862 nucleotide binding site [chemical binding]; other site 675635015863 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 675635015864 KMSKS motif; other site 675635015865 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 675635015866 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 675635015867 putative dimer interface [polypeptide binding]; other site 675635015868 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635015869 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 675635015870 homotrimer interaction site [polypeptide binding]; other site 675635015871 zinc binding site [ion binding]; other site 675635015872 CDP-binding sites; other site 675635015873 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 675635015874 substrate binding site; other site 675635015875 dimer interface; other site 675635015876 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 675635015877 Protein of unknown function (DUF461); Region: DUF461; cl01071 675635015878 DNA repair protein RadA; Provisional; Region: PRK11823 675635015879 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 675635015880 Walker A motif; other site 675635015881 ATP binding site [chemical binding]; other site 675635015882 Walker B motif; other site 675635015883 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 675635015884 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 675635015885 minor groove reading motif; other site 675635015886 helix-hairpin-helix signature motif; other site 675635015887 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 675635015888 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635015889 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635015890 catalytic site [active] 675635015891 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 675635015892 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 675635015893 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 675635015894 Clp amino terminal domain; Region: Clp_N; pfam02861 675635015895 Clp amino terminal domain; Region: Clp_N; pfam02861 675635015896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015897 Walker A motif; other site 675635015898 ATP binding site [chemical binding]; other site 675635015899 Walker B motif; other site 675635015900 arginine finger; other site 675635015901 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 675635015902 UvrB/uvrC motif; Region: UVR; pfam02151 675635015903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015904 Walker A motif; other site 675635015905 ATP binding site [chemical binding]; other site 675635015906 Walker B motif; other site 675635015907 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 675635015908 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 675635015909 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 675635015910 FAD binding pocket [chemical binding]; other site 675635015911 FAD binding motif [chemical binding]; other site 675635015912 phosphate binding motif [ion binding]; other site 675635015913 NAD binding pocket [chemical binding]; other site 675635015914 Lsr2; Region: Lsr2; pfam11774 675635015915 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 675635015916 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 675635015917 dimer interface [polypeptide binding]; other site 675635015918 putative anticodon binding site; other site 675635015919 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 675635015920 motif 1; other site 675635015921 dimer interface [polypeptide binding]; other site 675635015922 active site 675635015923 motif 2; other site 675635015924 motif 3; other site 675635015925 Type III pantothenate kinase; Region: Pan_kinase; cl17198 675635015926 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 675635015927 tetramerization interface [polypeptide binding]; other site 675635015928 active site 675635015929 pantoate--beta-alanine ligase; Region: panC; TIGR00018 675635015930 Pantoate-beta-alanine ligase; Region: PanC; cd00560 675635015931 active site 675635015932 ATP-binding site [chemical binding]; other site 675635015933 pantoate-binding site; other site 675635015934 HXXH motif; other site 675635015935 Rossmann-like domain; Region: Rossmann-like; pfam10727 675635015936 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 675635015937 Protease prsW family; Region: PrsW-protease; pfam13367 675635015938 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 675635015939 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 675635015940 catalytic center binding site [active] 675635015941 ATP binding site [chemical binding]; other site 675635015942 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 675635015943 homooctamer interface [polypeptide binding]; other site 675635015944 active site 675635015945 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 675635015946 substrate binding pocket [chemical binding]; other site 675635015947 inhibitor binding site; inhibition site 675635015948 GTP cyclohydrolase I; Provisional; Region: PLN03044 675635015949 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 675635015950 homodecamer interface [polypeptide binding]; other site 675635015951 active site 675635015952 putative catalytic site residues [active] 675635015953 zinc binding site [ion binding]; other site 675635015954 GTP-CH-I/GFRP interaction surface; other site 675635015955 FtsH Extracellular; Region: FtsH_ext; pfam06480 675635015956 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 675635015957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635015958 Walker A motif; other site 675635015959 ATP binding site [chemical binding]; other site 675635015960 Walker B motif; other site 675635015961 arginine finger; other site 675635015962 Peptidase family M41; Region: Peptidase_M41; pfam01434 675635015963 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635015964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635015965 active site 675635015966 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 675635015967 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 675635015968 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 675635015969 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 675635015970 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 675635015971 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 675635015972 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 675635015973 dimer interface [polypeptide binding]; other site 675635015974 substrate binding site [chemical binding]; other site 675635015975 metal binding sites [ion binding]; metal-binding site 675635015976 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 675635015977 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 675635015978 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 675635015979 homotrimer interaction site [polypeptide binding]; other site 675635015980 putative active site [active] 675635015981 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 675635015982 MoxR-like ATPases [General function prediction only]; Region: COG0714 675635015983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 675635015984 Walker B motif; other site 675635015985 arginine finger; other site 675635015986 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635015987 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635015988 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 675635015989 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635015990 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635015991 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635015992 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 675635015993 hypothetical protein; Provisional; Region: PRK07236 675635015994 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635015995 Amino acid permease; Region: AA_permease_2; pfam13520 675635015996 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635015997 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635015998 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 675635015999 active site 675635016000 AAA domain; Region: AAA_22; pfam13401 675635016001 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 675635016002 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635016003 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 675635016004 TAP-like protein; Region: Abhydrolase_4; pfam08386 675635016005 Transcriptional regulators [Transcription]; Region: MarR; COG1846 675635016006 MarR family; Region: MarR_2; pfam12802 675635016007 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 675635016008 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635016009 dimer interface [polypeptide binding]; other site 675635016010 active site 675635016011 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 675635016012 putative active site [active] 675635016013 putative catalytic site [active] 675635016014 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 675635016015 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 675635016016 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 675635016017 Survival protein SurE; Region: SurE; cl00448 675635016018 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635016019 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635016020 active site 675635016021 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 675635016022 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 675635016023 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 675635016024 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 675635016025 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 675635016026 carboxyltransferase (CT) interaction site; other site 675635016027 biotinylation site [posttranslational modification]; other site 675635016028 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 675635016029 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 675635016030 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 675635016031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635016032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635016033 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 675635016034 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635016035 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 675635016036 FAD binding pocket [chemical binding]; other site 675635016037 FAD binding motif [chemical binding]; other site 675635016038 phosphate binding motif [ion binding]; other site 675635016039 NAD binding pocket [chemical binding]; other site 675635016040 MbtH-like protein; Region: MbtH; pfam03621 675635016041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635016042 dimerization interface [polypeptide binding]; other site 675635016043 putative DNA binding site [nucleotide binding]; other site 675635016044 putative Zn2+ binding site [ion binding]; other site 675635016045 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 675635016046 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 675635016047 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 675635016048 putative active site [active] 675635016049 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 675635016050 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 675635016051 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 675635016052 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 675635016053 ThiC-associated domain; Region: ThiC-associated; pfam13667 675635016054 ThiC family; Region: ThiC; pfam01964 675635016055 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635016056 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635016057 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635016058 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 675635016059 DNA binding residues [nucleotide binding] 675635016060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 675635016061 dimerization interface [polypeptide binding]; other site 675635016062 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 675635016063 cyclase homology domain; Region: CHD; cd07302 675635016064 nucleotidyl binding site; other site 675635016065 metal binding site [ion binding]; metal-binding site 675635016066 dimer interface [polypeptide binding]; other site 675635016067 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 675635016068 active site 2 [active] 675635016069 active site 1 [active] 675635016070 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 675635016071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016072 NAD(P) binding site [chemical binding]; other site 675635016073 active site 675635016074 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 675635016075 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635016076 dimer interface [polypeptide binding]; other site 675635016077 active site 675635016078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635016079 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635016080 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635016081 active site 675635016082 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635016083 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 675635016084 putative NAD(P) binding site [chemical binding]; other site 675635016085 DinB superfamily; Region: DinB_2; pfam12867 675635016086 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635016087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635016088 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635016089 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635016090 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 675635016091 aminotransferase; Validated; Region: PRK07777 675635016092 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635016093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635016094 homodimer interface [polypeptide binding]; other site 675635016095 catalytic residue [active] 675635016096 Winged helix-turn helix; Region: HTH_29; pfam13551 675635016097 Homeodomain-like domain; Region: HTH_32; pfam13565 675635016098 DDE superfamily endonuclease; Region: DDE_3; pfam13358 675635016099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 675635016100 short chain dehydrogenase; Validated; Region: PRK05855 675635016101 classical (c) SDRs; Region: SDR_c; cd05233 675635016102 NAD(P) binding site [chemical binding]; other site 675635016103 active site 675635016104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635016105 putative substrate translocation pore; other site 675635016106 Predicted transcriptional regulators [Transcription]; Region: COG1695 675635016107 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 675635016108 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 675635016109 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 675635016110 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 675635016111 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635016112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635016113 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 675635016114 active site 675635016115 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 675635016116 Predicted membrane protein [Function unknown]; Region: COG2364 675635016117 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 675635016118 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 675635016119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635016120 Walker A/P-loop; other site 675635016121 ATP binding site [chemical binding]; other site 675635016122 Q-loop/lid; other site 675635016123 ABC transporter signature motif; other site 675635016124 Walker B; other site 675635016125 D-loop; other site 675635016126 H-loop/switch region; other site 675635016127 Bifunctional nuclease; Region: DNase-RNase; cl00553 675635016128 putative sialic acid transporter; Region: 2A0112; TIGR00891 675635016129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635016130 putative substrate translocation pore; other site 675635016131 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 675635016132 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 675635016133 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 675635016134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635016135 pyrimidine utilization protein A; Region: RutA; TIGR03612 675635016136 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635016137 active site 675635016138 dimer interface [polypeptide binding]; other site 675635016139 non-prolyl cis peptide bond; other site 675635016140 insertion regions; other site 675635016141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635016142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635016143 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635016144 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635016145 Amidase; Region: Amidase; pfam01425 675635016146 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635016147 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635016148 active site 675635016149 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635016150 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635016151 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 675635016152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635016153 DNA-binding site [nucleotide binding]; DNA binding site 675635016154 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635016155 NlpC/P60 family; Region: NLPC_P60; pfam00877 675635016156 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635016157 NlpC/P60 family; Region: NLPC_P60; pfam00877 675635016158 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635016159 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 675635016160 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 675635016161 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 675635016162 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 675635016163 ribonuclease Z; Reviewed; Region: PRK00055 675635016164 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635016165 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635016166 catalytic loop [active] 675635016167 iron binding site [ion binding]; other site 675635016168 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635016169 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635016170 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 675635016171 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635016172 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635016173 substrate binding site [chemical binding]; other site 675635016174 oxyanion hole (OAH) forming residues; other site 675635016175 trimer interface [polypeptide binding]; other site 675635016176 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 675635016177 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635016178 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635016179 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635016180 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 675635016181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016182 NAD(P) binding site [chemical binding]; other site 675635016183 active site 675635016184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635016185 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 675635016186 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635016187 acyl-activating enzyme (AAE) consensus motif; other site 675635016188 AMP binding site [chemical binding]; other site 675635016189 active site 675635016190 CoA binding site [chemical binding]; other site 675635016191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635016192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635016193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016194 NAD(P) binding site [chemical binding]; other site 675635016195 active site 675635016196 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 675635016197 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 675635016198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635016199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635016200 active site 675635016201 phosphorylation site [posttranslational modification] 675635016202 intermolecular recognition site; other site 675635016203 dimerization interface [polypeptide binding]; other site 675635016204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635016205 DNA binding residues [nucleotide binding] 675635016206 dimerization interface [polypeptide binding]; other site 675635016207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635016208 Histidine kinase; Region: HisKA_3; pfam07730 675635016209 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 675635016210 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 675635016211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 675635016212 catalytic residue [active] 675635016213 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 675635016214 lipoyl attachment site [posttranslational modification]; other site 675635016215 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 675635016216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635016217 non-specific DNA binding site [nucleotide binding]; other site 675635016218 salt bridge; other site 675635016219 sequence-specific DNA binding site [nucleotide binding]; other site 675635016220 Cupin domain; Region: Cupin_2; pfam07883 675635016221 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 675635016222 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 675635016223 dimerization interface [polypeptide binding]; other site 675635016224 ATP binding site [chemical binding]; other site 675635016225 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 675635016226 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 675635016227 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 675635016228 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 675635016229 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635016230 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635016231 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 675635016232 hydrophobic ligand binding site; other site 675635016233 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 675635016234 Phosphoglycerate kinase; Region: PGK; pfam00162 675635016235 substrate binding site [chemical binding]; other site 675635016236 hinge regions; other site 675635016237 ADP binding site [chemical binding]; other site 675635016238 catalytic site [active] 675635016239 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 675635016240 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 675635016241 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 675635016242 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 675635016243 Class I aldolases; Region: Aldolase_Class_I; cl17187 675635016244 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 675635016245 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 675635016246 putative substrate binding site [chemical binding]; other site 675635016247 nucleotide binding site [chemical binding]; other site 675635016248 nucleotide binding site [chemical binding]; other site 675635016249 homodimer interface [polypeptide binding]; other site 675635016250 Class I aldolases; Region: Aldolase_Class_I; cl17187 675635016251 catalytic residue [active] 675635016252 phosphoribulokinase; Provisional; Region: PRK07429 675635016253 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 675635016254 active site 675635016255 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 675635016256 TPP-binding site [chemical binding]; other site 675635016257 dimer interface [polypeptide binding]; other site 675635016258 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 675635016259 PYR/PP interface [polypeptide binding]; other site 675635016260 dimer interface [polypeptide binding]; other site 675635016261 TPP binding site [chemical binding]; other site 675635016262 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635016263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635016264 active site 675635016265 phosphorylation site [posttranslational modification] 675635016266 intermolecular recognition site; other site 675635016267 dimerization interface [polypeptide binding]; other site 675635016268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635016269 DNA binding residues [nucleotide binding] 675635016270 dimerization interface [polypeptide binding]; other site 675635016271 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635016272 GAF domain; Region: GAF; pfam01590 675635016273 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635016274 Histidine kinase; Region: HisKA_3; pfam07730 675635016275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635016276 ATP binding site [chemical binding]; other site 675635016277 Mg2+ binding site [ion binding]; other site 675635016278 G-X-G motif; other site 675635016279 Helix-turn-helix domain; Region: HTH_38; pfam13936 675635016280 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635016281 Integrase core domain; Region: rve; pfam00665 675635016282 Class I aldolases; Region: Aldolase_Class_I; cl17187 675635016283 catalytic residue [active] 675635016284 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 675635016285 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 675635016286 homodimer interface [polypeptide binding]; other site 675635016287 active site 675635016288 heterodimer interface [polypeptide binding]; other site 675635016289 catalytic residue [active] 675635016290 metal binding site [ion binding]; metal-binding site 675635016291 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 675635016292 multimerization interface [polypeptide binding]; other site 675635016293 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 675635016294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635016295 Walker A motif; other site 675635016296 ATP binding site [chemical binding]; other site 675635016297 Walker B motif; other site 675635016298 arginine finger; other site 675635016299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 675635016300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635016301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635016302 dimerization interface [polypeptide binding]; other site 675635016303 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635016304 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635016305 DNA binding residues [nucleotide binding] 675635016306 dimerization interface [polypeptide binding]; other site 675635016307 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635016308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635016309 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 675635016310 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635016311 active site residue [active] 675635016312 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635016313 active site residue [active] 675635016314 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 675635016315 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 675635016316 active site 675635016317 non-prolyl cis peptide bond; other site 675635016318 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 675635016319 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 675635016320 Walker A/P-loop; other site 675635016321 ATP binding site [chemical binding]; other site 675635016322 Q-loop/lid; other site 675635016323 ABC transporter signature motif; other site 675635016324 Walker B; other site 675635016325 D-loop; other site 675635016326 H-loop/switch region; other site 675635016327 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 675635016328 Walker A/P-loop; other site 675635016329 ATP binding site [chemical binding]; other site 675635016330 Q-loop/lid; other site 675635016331 ABC transporter signature motif; other site 675635016332 Walker B; other site 675635016333 D-loop; other site 675635016334 H-loop/switch region; other site 675635016335 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 675635016336 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 675635016337 TM-ABC transporter signature motif; other site 675635016338 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 675635016339 TM-ABC transporter signature motif; other site 675635016340 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 675635016341 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 675635016342 ligand binding site [chemical binding]; other site 675635016343 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635016344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635016345 DNA-binding site [nucleotide binding]; DNA binding site 675635016346 FCD domain; Region: FCD; pfam07729 675635016347 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 675635016348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635016349 dimer interface [polypeptide binding]; other site 675635016350 conserved gate region; other site 675635016351 putative PBP binding loops; other site 675635016352 ABC-ATPase subunit interface; other site 675635016353 NMT1-like family; Region: NMT1_2; pfam13379 675635016354 NMT1/THI5 like; Region: NMT1; pfam09084 675635016355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635016356 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 675635016357 Walker A/P-loop; other site 675635016358 ATP binding site [chemical binding]; other site 675635016359 Q-loop/lid; other site 675635016360 ABC transporter signature motif; other site 675635016361 Walker B; other site 675635016362 D-loop; other site 675635016363 H-loop/switch region; other site 675635016364 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635016365 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635016366 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 675635016367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635016368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635016369 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 675635016370 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 675635016371 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 675635016372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635016373 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 675635016374 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 675635016375 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635016376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635016377 active site 675635016378 metal binding site [ion binding]; metal-binding site 675635016379 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 675635016380 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 675635016381 membrane protein FdrA; Validated; Region: PRK06091 675635016382 CoA binding domain; Region: CoA_binding; cl17356 675635016383 CoA-ligase; Region: Ligase_CoA; pfam00549 675635016384 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 675635016385 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 675635016386 putative substrate binding site [chemical binding]; other site 675635016387 nucleotide binding site [chemical binding]; other site 675635016388 nucleotide binding site [chemical binding]; other site 675635016389 homodimer interface [polypeptide binding]; other site 675635016390 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 675635016391 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 675635016392 DNA binding site [nucleotide binding] 675635016393 AAA ATPase domain; Region: AAA_16; pfam13191 675635016394 Tetratricopeptide repeat; Region: TPR_12; pfam13424 675635016395 Tetratricopeptide repeats; Region: TPR; smart00028 675635016396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 675635016397 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 675635016398 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 675635016399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635016400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635016401 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635016402 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 675635016403 Dienelactone hydrolase family; Region: DLH; pfam01738 675635016404 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 675635016405 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 675635016406 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 675635016407 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635016408 active site 675635016409 nucleotide binding site [chemical binding]; other site 675635016410 HIGH motif; other site 675635016411 KMSKS motif; other site 675635016412 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635016413 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 675635016414 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 675635016415 active site 675635016416 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 675635016417 Uncharacterized conserved protein [Function unknown]; Region: COG1432 675635016418 LabA_like proteins; Region: LabA_like; cd06167 675635016419 putative metal binding site [ion binding]; other site 675635016420 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 675635016421 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 675635016422 Predicted transcriptional regulators [Transcription]; Region: COG1733 675635016423 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 675635016424 short chain dehydrogenase; Validated; Region: PRK08264 675635016425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016426 NAD(P) binding site [chemical binding]; other site 675635016427 active site 675635016428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635016429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635016430 DNA binding residues [nucleotide binding] 675635016431 dimerization interface [polypeptide binding]; other site 675635016432 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 675635016433 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 675635016434 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 675635016435 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 675635016436 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 675635016437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635016438 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 675635016439 Beta-lactamase; Region: Beta-lactamase; pfam00144 675635016440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635016441 dimerization interface [polypeptide binding]; other site 675635016442 putative DNA binding site [nucleotide binding]; other site 675635016443 putative Zn2+ binding site [ion binding]; other site 675635016444 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 675635016445 putative hydrophobic ligand binding site [chemical binding]; other site 675635016446 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 675635016447 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 675635016448 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 675635016449 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 675635016450 OsmC-like protein; Region: OsmC; pfam02566 675635016451 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635016452 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635016453 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635016454 DNA binding residues [nucleotide binding] 675635016455 Amidohydrolase; Region: Amidohydro_2; pfam04909 675635016456 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 675635016457 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 675635016458 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 675635016459 iron-sulfur cluster [ion binding]; other site 675635016460 [2Fe-2S] cluster binding site [ion binding]; other site 675635016461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635016462 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635016463 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 675635016464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635016465 methionine sulfoxide reductase A; Provisional; Region: PRK14054 675635016466 DNA binding site [nucleotide binding] 675635016467 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 675635016468 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 675635016469 Predicted ATPase [General function prediction only]; Region: COG3903 675635016470 short chain dehydrogenase; Provisional; Region: PRK07041 675635016471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635016472 NAD(P) binding site [chemical binding]; other site 675635016473 active site 675635016474 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 675635016475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635016476 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 675635016477 dimerization interface [polypeptide binding]; other site 675635016478 substrate binding pocket [chemical binding]; other site 675635016479 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 675635016480 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635016481 ligand binding site [chemical binding]; other site 675635016482 flexible hinge region; other site 675635016483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635016484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635016485 ATP binding site [chemical binding]; other site 675635016486 Mg2+ binding site [ion binding]; other site 675635016487 G-X-G motif; other site 675635016488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 675635016489 ATP binding site [chemical binding]; other site 675635016490 putative Mg++ binding site [ion binding]; other site 675635016491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 675635016492 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 675635016493 nucleotide binding region [chemical binding]; other site 675635016494 ATP-binding site [chemical binding]; other site 675635016495 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 675635016496 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635016497 DNA binding residues [nucleotide binding] 675635016498 classical (c) SDRs; Region: SDR_c; cd05233 675635016499 NAD(P) binding site [chemical binding]; other site 675635016500 active site 675635016501 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635016502 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 675635016503 enoyl-CoA hydratase; Provisional; Region: PRK12478 675635016504 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635016505 substrate binding site [chemical binding]; other site 675635016506 oxyanion hole (OAH) forming residues; other site 675635016507 trimer interface [polypeptide binding]; other site 675635016508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635016509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635016510 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 675635016511 gating phenylalanine in ion channel; other site 675635016512 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 675635016513 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 675635016514 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635016515 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635016516 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635016517 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 675635016518 hypothetical protein; Provisional; Region: PRK07236 675635016519 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 675635016520 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635016521 acyl-activating enzyme (AAE) consensus motif; other site 675635016522 AMP binding site [chemical binding]; other site 675635016523 active site 675635016524 CoA binding site [chemical binding]; other site 675635016525 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 675635016526 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 675635016527 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635016528 Zn binding site [ion binding]; other site 675635016529 Helix-turn-helix domain; Region: HTH_38; pfam13936 675635016530 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 675635016531 Integrase core domain; Region: rve; pfam00665 675635016532 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 675635016533 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 675635016534 A new structural DNA glycosylase; Region: AlkD_like; cd06561 675635016535 active site 675635016536 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 675635016537 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 675635016538 putative dimer interface [polypeptide binding]; other site 675635016539 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635016540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635016541 active site 675635016542 phosphorylation site [posttranslational modification] 675635016543 intermolecular recognition site; other site 675635016544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635016545 DNA binding residues [nucleotide binding] 675635016546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635016547 Histidine kinase; Region: HisKA_3; pfam07730 675635016548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635016549 ATP binding site [chemical binding]; other site 675635016550 Mg2+ binding site [ion binding]; other site 675635016551 G-X-G motif; other site 675635016552 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635016553 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635016554 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635016555 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 675635016556 DDE superfamily endonuclease; Region: DDE_5; pfam13546 675635016557 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635016558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635016559 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635016560 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 675635016561 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 675635016562 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 675635016563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635016564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635016565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635016566 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 675635016567 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 675635016568 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 675635016569 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 675635016570 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 675635016571 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 675635016572 nickel binding site [ion binding]; other site 675635016573 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 675635016574 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 675635016575 iron-sulfur cluster [ion binding]; other site 675635016576 [2Fe-2S] cluster binding site [ion binding]; other site 675635016577 Acylphosphatase; Region: Acylphosphatase; pfam00708 675635016578 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 675635016579 HypF finger; Region: zf-HYPF; pfam07503 675635016580 HypF finger; Region: zf-HYPF; pfam07503 675635016581 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 675635016582 HupF/HypC family; Region: HupF_HypC; pfam01455 675635016583 HupF/HypC family; Region: HupF_HypC; pfam01455 675635016584 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 675635016585 active site 675635016586 dimer interface [polypeptide binding]; other site 675635016587 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 675635016588 dimerization interface [polypeptide binding]; other site 675635016589 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 675635016590 ATP binding site [chemical binding]; other site 675635016591 HupF/HypC family; Region: HupF_HypC; pfam01455 675635016592 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 675635016593 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 675635016594 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 675635016595 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 675635016596 active site 675635016597 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 675635016598 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 675635016599 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635016600 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 675635016601 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 675635016602 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635016603 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 675635016604 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 675635016605 Peptidase family M23; Region: Peptidase_M23; pfam01551 675635016606 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635016607 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 675635016608 hypothetical protein; Provisional; Region: PRK14851 675635016609 Amidase; Region: Amidase; cl11426 675635016610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635016611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635016612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635016613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635016614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635016615 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 675635016616 Walker A/P-loop; other site 675635016617 ATP binding site [chemical binding]; other site 675635016618 Q-loop/lid; other site 675635016619 ABC transporter signature motif; other site 675635016620 Walker B; other site 675635016621 D-loop; other site 675635016622 H-loop/switch region; other site 675635016623 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635016624 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635016625 metal-binding site [ion binding] 675635016626 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635016627 Soluble P-type ATPase [General function prediction only]; Region: COG4087 675635016628 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 675635016629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 675635016630 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635016631 metal-binding site [ion binding] 675635016632 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635016633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635016634 DNA binding residues [nucleotide binding] 675635016635 dimerization interface [polypeptide binding]; other site 675635016636 hypothetical protein; Provisional; Region: PRK04164 675635016637 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 675635016638 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 675635016639 putative catalytic site [active] 675635016640 putative metal binding site [ion binding]; other site 675635016641 putative phosphate binding site [ion binding]; other site 675635016642 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 675635016643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 675635016644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635016645 active site 675635016646 phosphorylation site [posttranslational modification] 675635016647 intermolecular recognition site; other site 675635016648 dimerization interface [polypeptide binding]; other site 675635016649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 675635016650 DNA binding site [nucleotide binding] 675635016651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 675635016652 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 675635016653 dimerization interface [polypeptide binding]; other site 675635016654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635016655 dimer interface [polypeptide binding]; other site 675635016656 phosphorylation site [posttranslational modification] 675635016657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635016658 ATP binding site [chemical binding]; other site 675635016659 Mg2+ binding site [ion binding]; other site 675635016660 G-X-G motif; other site 675635016661 DoxX; Region: DoxX; pfam07681 675635016662 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 675635016663 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 675635016664 Cl- selectivity filter; other site 675635016665 Cl- binding residues [ion binding]; other site 675635016666 pore gating glutamate residue; other site 675635016667 dimer interface [polypeptide binding]; other site 675635016668 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 675635016669 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 675635016670 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 675635016671 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 675635016672 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 675635016673 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 675635016674 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 675635016675 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 675635016676 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 675635016677 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 675635016678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635016679 S-adenosylmethionine binding site [chemical binding]; other site 675635016680 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 675635016681 DNA-binding site [nucleotide binding]; DNA binding site 675635016682 RNA-binding motif; other site 675635016683 tyramine oxidase; Provisional; Region: tynA; PRK11504 675635016684 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 675635016685 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 675635016686 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 675635016687 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 675635016688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635016689 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 675635016690 GAF domain; Region: GAF_3; pfam13492 675635016691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 675635016692 dimer interface [polypeptide binding]; other site 675635016693 phosphorylation site [posttranslational modification] 675635016694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635016695 ATP binding site [chemical binding]; other site 675635016696 Mg2+ binding site [ion binding]; other site 675635016697 G-X-G motif; other site 675635016698 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 675635016699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635016700 active site 675635016701 phosphorylation site [posttranslational modification] 675635016702 intermolecular recognition site; other site 675635016703 dimerization interface [polypeptide binding]; other site 675635016704 Response regulator receiver domain; Region: Response_reg; pfam00072 675635016705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635016706 active site 675635016707 phosphorylation site [posttranslational modification] 675635016708 intermolecular recognition site; other site 675635016709 dimerization interface [polypeptide binding]; other site 675635016710 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 675635016711 Response regulator receiver domain; Region: Response_reg; pfam00072 675635016712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635016713 active site 675635016714 phosphorylation site [posttranslational modification] 675635016715 intermolecular recognition site; other site 675635016716 dimerization interface [polypeptide binding]; other site 675635016717 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 675635016718 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 675635016719 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635016720 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635016721 ligand binding site [chemical binding]; other site 675635016722 flexible hinge region; other site 675635016723 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 675635016724 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 675635016725 nucleophile elbow; other site 675635016726 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 675635016727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635016728 active site 675635016729 phosphorylation site [posttranslational modification] 675635016730 intermolecular recognition site; other site 675635016731 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635016732 FAD binding domain; Region: FAD_binding_4; pfam01565 675635016733 Berberine and berberine like; Region: BBE; pfam08031 675635016734 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 675635016735 AAA ATPase domain; Region: AAA_16; pfam13191 675635016736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635016737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635016738 DNA binding residues [nucleotide binding] 675635016739 dimerization interface [polypeptide binding]; other site 675635016740 Hemerythrin family; Region: Hemerythrin-like; cl15774 675635016741 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635016742 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 675635016743 substrate binding site [chemical binding]; other site 675635016744 THF binding site; other site 675635016745 zinc-binding site [ion binding]; other site 675635016746 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 675635016747 Beta-lactamase; Region: Beta-lactamase; pfam00144 675635016748 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 675635016749 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635016750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635016751 putative substrate translocation pore; other site 675635016752 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 675635016753 Cytochrome P450; Region: p450; cl12078 675635016754 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 675635016755 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635016756 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635016757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635016758 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 675635016759 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635016760 acyl-activating enzyme (AAE) consensus motif; other site 675635016761 AMP binding site [chemical binding]; other site 675635016762 active site 675635016763 CoA binding site [chemical binding]; other site 675635016764 hypothetical protein; Provisional; Region: PRK06847 675635016765 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635016766 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 675635016767 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 675635016768 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 675635016769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 675635016770 active site 675635016771 metal binding site [ion binding]; metal-binding site 675635016772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 675635016773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635016774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635016775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635016776 DNA-binding site [nucleotide binding]; DNA binding site 675635016777 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635016778 FCD domain; Region: FCD; pfam07729 675635016779 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 675635016780 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 675635016781 NAD(P) binding site [chemical binding]; other site 675635016782 catalytic residues [active] 675635016783 benzoate transport; Region: 2A0115; TIGR00895 675635016784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635016785 putative substrate translocation pore; other site 675635016786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635016787 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635016788 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635016789 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 675635016790 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635016791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635016792 substrate binding site [chemical binding]; other site 675635016793 trimer interface [polypeptide binding]; other site 675635016794 oxyanion hole (OAH) forming residues; other site 675635016795 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635016796 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 675635016797 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 675635016798 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635016799 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 675635016800 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 675635016801 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 675635016802 Protein of unknown function (DUF917); Region: DUF917; pfam06032 675635016803 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 675635016804 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 675635016805 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 675635016806 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635016807 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 675635016808 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635016809 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635016810 catalytic loop [active] 675635016811 iron binding site [ion binding]; other site 675635016812 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635016813 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635016814 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635016815 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635016816 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 675635016817 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635016818 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635016819 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 675635016820 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 675635016821 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635016822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635016823 catalytic loop [active] 675635016824 iron binding site [ion binding]; other site 675635016825 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635016826 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 675635016827 active site 675635016828 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 675635016829 active site 675635016830 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 675635016831 dimer interface [polypeptide binding]; other site 675635016832 non-prolyl cis peptide bond; other site 675635016833 insertion regions; other site 675635016834 Domain of unknown function (DUF336); Region: DUF336; pfam03928 675635016835 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 675635016836 classical (c) SDRs; Region: SDR_c; cd05233 675635016837 NAD(P) binding site [chemical binding]; other site 675635016838 active site 675635016839 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 675635016840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 675635016841 TIGR02679 family protein; Region: TIGR02679 675635016842 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 675635016843 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 675635016844 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 675635016845 TIGR02677 family protein; Region: TIGR02677 675635016846 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 675635016847 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 675635016848 Divergent AAA domain; Region: AAA_4; pfam04326 675635016849 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 675635016850 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 675635016851 DNA polymerase III subunit delta'; Validated; Region: PRK07940 675635016852 DNA polymerase III subunit delta'; Validated; Region: PRK08485 675635016853 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 675635016854 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 675635016855 Transglycosylase; Region: Transgly; pfam00912 675635016856 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 675635016857 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 675635016858 Transcription factor WhiB; Region: Whib; pfam02467 675635016859 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 675635016860 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 675635016861 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 675635016862 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 675635016863 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 675635016864 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 675635016865 P loop; other site 675635016866 Nucleotide binding site [chemical binding]; other site 675635016867 DTAP/Switch II; other site 675635016868 Switch I; other site 675635016869 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 675635016870 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 675635016871 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 675635016872 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 675635016873 homotrimer interaction site [polypeptide binding]; other site 675635016874 putative active site [active] 675635016875 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635016876 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 675635016877 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 675635016878 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 675635016879 ligand binding site [chemical binding]; other site 675635016880 flexible hinge region; other site 675635016881 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 675635016882 putative switch regulator; other site 675635016883 non-specific DNA interactions [nucleotide binding]; other site 675635016884 DNA binding site [nucleotide binding] 675635016885 sequence specific DNA binding site [nucleotide binding]; other site 675635016886 putative cAMP binding site [chemical binding]; other site 675635016887 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 675635016888 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 675635016889 minor groove reading motif; other site 675635016890 helix-hairpin-helix signature motif; other site 675635016891 substrate binding pocket [chemical binding]; other site 675635016892 active site 675635016893 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 675635016894 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 675635016895 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 675635016896 catalytic residues [active] 675635016897 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 675635016898 putative active site [active] 675635016899 putative CoA binding site [chemical binding]; other site 675635016900 nudix motif; other site 675635016901 metal binding site [ion binding]; metal-binding site 675635016902 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 675635016903 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 675635016904 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 675635016905 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 675635016906 GDP-binding site [chemical binding]; other site 675635016907 ACT binding site; other site 675635016908 IMP binding site; other site 675635016909 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 675635016910 alpha-gamma subunit interface [polypeptide binding]; other site 675635016911 beta-gamma subunit interface [polypeptide binding]; other site 675635016912 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 675635016913 alpha-beta subunit interface [polypeptide binding]; other site 675635016914 urease subunit alpha; Reviewed; Region: ureC; PRK13206 675635016915 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 675635016916 subunit interactions [polypeptide binding]; other site 675635016917 active site 675635016918 flap region; other site 675635016919 UreF; Region: UreF; pfam01730 675635016920 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 675635016921 AAA domain; Region: AAA_18; pfam13238 675635016922 UreD urease accessory protein; Region: UreD; cl00530 675635016923 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 675635016924 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 675635016925 putative acyl-acceptor binding pocket; other site 675635016926 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 675635016927 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 675635016928 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 675635016929 active site 675635016930 intersubunit interface [polypeptide binding]; other site 675635016931 zinc binding site [ion binding]; other site 675635016932 Na+ binding site [ion binding]; other site 675635016933 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635016934 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635016935 DNA binding residues [nucleotide binding] 675635016936 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635016937 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 675635016938 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 675635016939 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 675635016940 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 675635016941 hypothetical protein; Provisional; Region: PRK08204 675635016942 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635016943 active site 675635016944 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 675635016945 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 675635016946 Bacterial transcriptional regulator; Region: IclR; pfam01614 675635016947 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635016948 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635016949 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 675635016950 active site 675635016951 citrylCoA binding site [chemical binding]; other site 675635016952 oxalacetate binding site [chemical binding]; other site 675635016953 coenzyme A binding site [chemical binding]; other site 675635016954 catalytic triad [active] 675635016955 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 675635016956 active site 675635016957 Fe(II) binding site [ion binding]; other site 675635016958 dimer interface [polypeptide binding]; other site 675635016959 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 675635016960 tetramer interface [polypeptide binding]; other site 675635016961 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 675635016962 dimer interface [polypeptide binding]; other site 675635016963 tetramer interface [polypeptide binding]; other site 675635016964 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 675635016965 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 675635016966 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635016967 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635016968 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 675635016969 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 675635016970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635016971 Walker A motif; other site 675635016972 ATP binding site [chemical binding]; other site 675635016973 Walker B motif; other site 675635016974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 675635016975 Peptidase family M41; Region: Peptidase_M41; pfam01434 675635016976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 675635016977 active site 675635016978 classical (c) SDRs; Region: SDR_c; cd05233 675635016979 NAD(P) binding site [chemical binding]; other site 675635016980 active site 675635016981 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 675635016982 Clp amino terminal domain; Region: Clp_N; pfam02861 675635016983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635016984 Walker A motif; other site 675635016985 ATP binding site [chemical binding]; other site 675635016986 Walker B motif; other site 675635016987 arginine finger; other site 675635016988 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 675635016989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635016990 Walker A motif; other site 675635016991 ATP binding site [chemical binding]; other site 675635016992 Walker B motif; other site 675635016993 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 675635016994 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 675635016995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635016996 ATP binding site [chemical binding]; other site 675635016997 Walker B motif; other site 675635016998 arginine finger; other site 675635016999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 675635017000 TPR motif; other site 675635017001 Tetratricopeptide repeat; Region: TPR_16; pfam13432 675635017002 binding surface 675635017003 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 675635017004 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 675635017005 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 675635017006 heme-binding site [chemical binding]; other site 675635017007 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 675635017008 FAD binding pocket [chemical binding]; other site 675635017009 FAD binding motif [chemical binding]; other site 675635017010 phosphate binding motif [ion binding]; other site 675635017011 beta-alpha-beta structure motif; other site 675635017012 NAD binding pocket [chemical binding]; other site 675635017013 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635017014 DNA binding residues [nucleotide binding] 675635017015 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 675635017016 chaperone protein DnaJ; Provisional; Region: PRK14279 675635017017 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 675635017018 HSP70 interaction site [polypeptide binding]; other site 675635017019 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 675635017020 Zn binding sites [ion binding]; other site 675635017021 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 675635017022 dimer interface [polypeptide binding]; other site 675635017023 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 675635017024 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 675635017025 dimer interface [polypeptide binding]; other site 675635017026 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 675635017027 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 675635017028 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 675635017029 nucleotide binding site [chemical binding]; other site 675635017030 NEF interaction site [polypeptide binding]; other site 675635017031 SBD interface [polypeptide binding]; other site 675635017032 EspG family; Region: ESX-1_EspG; pfam14011 675635017033 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635017034 NlpC/P60 family; Region: NLPC_P60; pfam00877 675635017035 AAA-like domain; Region: AAA_10; pfam12846 675635017036 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 675635017037 4Fe-4S binding domain; Region: Fer4; pfam00037 675635017038 Cysteine-rich domain; Region: CCG; pfam02754 675635017039 Cysteine-rich domain; Region: CCG; pfam02754 675635017040 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635017041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635017042 active site 675635017043 phosphorylation site [posttranslational modification] 675635017044 intermolecular recognition site; other site 675635017045 dimerization interface [polypeptide binding]; other site 675635017046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635017047 DNA binding residues [nucleotide binding] 675635017048 dimerization interface [polypeptide binding]; other site 675635017049 Histidine kinase; Region: HisKA_3; pfam07730 675635017050 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 675635017051 ATP binding site [chemical binding]; other site 675635017052 Mg2+ binding site [ion binding]; other site 675635017053 G-X-G motif; other site 675635017054 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 675635017055 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 675635017056 Walker A/P-loop; other site 675635017057 ATP binding site [chemical binding]; other site 675635017058 Q-loop/lid; other site 675635017059 ABC transporter signature motif; other site 675635017060 Walker B; other site 675635017061 D-loop; other site 675635017062 H-loop/switch region; other site 675635017063 2'-deoxycytidine 5'-triphosphate deaminase (DCD); Region: DCD; pfam06559 675635017064 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 675635017065 trimer interface [polypeptide binding]; other site 675635017066 active site 675635017067 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 675635017068 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635017069 FAD binding domain; Region: FAD_binding_3; pfam01494 675635017070 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 675635017071 AAA domain; Region: AAA_18; pfam13238 675635017072 active site 675635017073 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635017074 NlpC/P60 family; Region: NLPC_P60; pfam00877 675635017075 AAA-like domain; Region: AAA_10; pfam12846 675635017076 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 675635017077 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 675635017078 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635017079 P-loop; other site 675635017080 Magnesium ion binding site [ion binding]; other site 675635017081 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 675635017082 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 675635017083 nucleotide binding site [chemical binding]; other site 675635017084 putative NEF/HSP70 interaction site [polypeptide binding]; other site 675635017085 SBD interface [polypeptide binding]; other site 675635017086 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 675635017087 Dynamin family; Region: Dynamin_N; pfam00350 675635017088 G1 box; other site 675635017089 GTP/Mg2+ binding site [chemical binding]; other site 675635017090 G2 box; other site 675635017091 Switch I region; other site 675635017092 G3 box; other site 675635017093 Switch II region; other site 675635017094 G4 box; other site 675635017095 G5 box; other site 675635017096 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 675635017097 Dynamin family; Region: Dynamin_N; pfam00350 675635017098 G1 box; other site 675635017099 GTP/Mg2+ binding site [chemical binding]; other site 675635017100 G2 box; other site 675635017101 Switch I region; other site 675635017102 G3 box; other site 675635017103 Switch II region; other site 675635017104 G4 box; other site 675635017105 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 675635017106 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635017107 catalytic loop [active] 675635017108 iron binding site [ion binding]; other site 675635017109 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 675635017110 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 675635017111 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635017112 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 675635017113 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 675635017114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635017115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635017116 DNA binding residues [nucleotide binding] 675635017117 dimerization interface [polypeptide binding]; other site 675635017118 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 675635017119 amidase catalytic site [active] 675635017120 Zn binding residues [ion binding]; other site 675635017121 substrate binding site [chemical binding]; other site 675635017122 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 675635017123 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 675635017124 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 675635017125 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635017126 active site 675635017127 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 675635017128 FOG: CBS domain [General function prediction only]; Region: COG0517 675635017129 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 675635017130 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 675635017131 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 675635017132 VanW like protein; Region: VanW; pfam04294 675635017133 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 675635017134 oligomerisation interface [polypeptide binding]; other site 675635017135 mobile loop; other site 675635017136 roof hairpin; other site 675635017137 AAA ATPase domain; Region: AAA_16; pfam13191 675635017138 AAA domain; Region: AAA_22; pfam13401 675635017139 Protein of unknown function (DUF541); Region: SIMPL; cl01077 675635017140 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 675635017141 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 675635017142 E3 interaction surface; other site 675635017143 lipoyl attachment site [posttranslational modification]; other site 675635017144 e3 binding domain; Region: E3_binding; pfam02817 675635017145 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 675635017146 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 675635017147 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 675635017148 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 675635017149 alpha subunit interface [polypeptide binding]; other site 675635017150 TPP binding site [chemical binding]; other site 675635017151 heterodimer interface [polypeptide binding]; other site 675635017152 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 675635017153 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 675635017154 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 675635017155 TPP-binding site [chemical binding]; other site 675635017156 tetramer interface [polypeptide binding]; other site 675635017157 heterodimer interface [polypeptide binding]; other site 675635017158 phosphorylation loop region [posttranslational modification] 675635017159 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 675635017160 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 675635017161 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 675635017162 substrate binding pocket [chemical binding]; other site 675635017163 membrane-bound complex binding site; other site 675635017164 hinge residues; other site 675635017165 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 675635017166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635017167 dimer interface [polypeptide binding]; other site 675635017168 conserved gate region; other site 675635017169 putative PBP binding loops; other site 675635017170 ABC-ATPase subunit interface; other site 675635017171 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 675635017172 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 675635017173 Walker A/P-loop; other site 675635017174 ATP binding site [chemical binding]; other site 675635017175 Q-loop/lid; other site 675635017176 ABC transporter signature motif; other site 675635017177 Walker B; other site 675635017178 D-loop; other site 675635017179 H-loop/switch region; other site 675635017180 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 675635017181 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 675635017182 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 675635017183 Na binding site [ion binding]; other site 675635017184 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 675635017185 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 675635017186 active site 675635017187 substrate-binding site [chemical binding]; other site 675635017188 metal-binding site [ion binding] 675635017189 GTP binding site [chemical binding]; other site 675635017190 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 675635017191 Predicted transcriptional regulator [Transcription]; Region: COG2378 675635017192 HTH domain; Region: HTH_11; pfam08279 675635017193 WYL domain; Region: WYL; pfam13280 675635017194 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 675635017195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 675635017196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 675635017197 dimerization interface [polypeptide binding]; other site 675635017198 Lysine efflux permease [General function prediction only]; Region: COG1279 675635017199 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 675635017200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635017201 putative substrate translocation pore; other site 675635017202 hypothetical protein; Provisional; Region: PRK06184 675635017203 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 675635017204 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 675635017205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 675635017206 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 675635017207 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 675635017208 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 675635017209 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 675635017210 active site 675635017211 dimer interface [polypeptide binding]; other site 675635017212 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 675635017213 CoenzymeA binding site [chemical binding]; other site 675635017214 subunit interaction site [polypeptide binding]; other site 675635017215 PHB binding site; other site 675635017216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635017217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635017218 ATP binding site [chemical binding]; other site 675635017219 Mg2+ binding site [ion binding]; other site 675635017220 G-X-G motif; other site 675635017221 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635017222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635017223 active site 675635017224 phosphorylation site [posttranslational modification] 675635017225 intermolecular recognition site; other site 675635017226 dimerization interface [polypeptide binding]; other site 675635017227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635017228 DNA binding residues [nucleotide binding] 675635017229 dimerization interface [polypeptide binding]; other site 675635017230 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 675635017231 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 675635017232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635017233 dimer interface [polypeptide binding]; other site 675635017234 conserved gate region; other site 675635017235 putative PBP binding loops; other site 675635017236 ABC-ATPase subunit interface; other site 675635017237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 675635017238 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 675635017239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 675635017240 Walker A/P-loop; other site 675635017241 ATP binding site [chemical binding]; other site 675635017242 Q-loop/lid; other site 675635017243 ABC transporter signature motif; other site 675635017244 Walker B; other site 675635017245 D-loop; other site 675635017246 H-loop/switch region; other site 675635017247 TOBE domain; Region: TOBE_2; pfam08402 675635017248 LabA_like proteins; Region: LabA_like; cd06167 675635017249 putative metal binding site [ion binding]; other site 675635017250 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 675635017251 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635017252 active site 675635017253 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 675635017254 Domain of unknown function DUF20; Region: UPF0118; pfam01594 675635017255 Coenzyme A transferase; Region: CoA_trans; cl17247 675635017256 Coenzyme A transferase; Region: CoA_trans; cl17247 675635017257 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 675635017258 replicative DNA helicase; Provisional; Region: PRK05636 675635017259 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 675635017260 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 675635017261 Walker A motif; other site 675635017262 ATP binding site [chemical binding]; other site 675635017263 Walker B motif; other site 675635017264 DNA binding loops [nucleotide binding] 675635017265 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 675635017266 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 675635017267 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 675635017268 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 675635017269 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 675635017270 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 675635017271 dimer interface [polypeptide binding]; other site 675635017272 ssDNA binding site [nucleotide binding]; other site 675635017273 tetramer (dimer of dimers) interface [polypeptide binding]; other site 675635017274 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 675635017275 endonuclease IV; Provisional; Region: PRK01060 675635017276 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 675635017277 AP (apurinic/apyrimidinic) site pocket; other site 675635017278 DNA interaction; other site 675635017279 Metal-binding active site; metal-binding site 675635017280 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 675635017281 putative active site [active] 675635017282 putative CoA binding site [chemical binding]; other site 675635017283 nudix motif; other site 675635017284 metal binding site [ion binding]; metal-binding site 675635017285 Predicted integral membrane protein [Function unknown]; Region: COG5650 675635017286 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 675635017287 Transglycosylase; Region: Transgly; pfam00912 675635017288 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 675635017289 Predicted transcriptional regulators [Transcription]; Region: COG1695 675635017290 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 675635017291 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 675635017292 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 675635017293 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635017294 NlpC/P60 family; Region: NLPC_P60; pfam00877 675635017295 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 675635017296 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 675635017297 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 675635017298 HIGH motif; other site 675635017299 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 675635017300 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635017301 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 675635017302 active site 675635017303 KMSKS motif; other site 675635017304 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 675635017305 tRNA binding surface [nucleotide binding]; other site 675635017306 hypothetical protein; Validated; Region: PRK00228 675635017307 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 675635017308 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 675635017309 active site 675635017310 NTP binding site [chemical binding]; other site 675635017311 metal binding triad [ion binding]; metal-binding site 675635017312 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 675635017313 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 675635017314 Zn2+ binding site [ion binding]; other site 675635017315 Mg2+ binding site [ion binding]; other site 675635017316 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 675635017317 active site 675635017318 Ap6A binding site [chemical binding]; other site 675635017319 nudix motif; other site 675635017320 metal binding site [ion binding]; metal-binding site 675635017321 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 675635017322 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 675635017323 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 675635017324 DNA binding residues [nucleotide binding] 675635017325 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 675635017326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 675635017327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635017328 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 675635017329 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 675635017330 catalytic residues [active] 675635017331 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 675635017332 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 675635017333 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 675635017334 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 675635017335 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 675635017336 active site 675635017337 metal binding site [ion binding]; metal-binding site 675635017338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 675635017339 Coenzyme A binding pocket [chemical binding]; other site 675635017340 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 675635017341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 675635017342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 675635017343 homodimer interface [polypeptide binding]; other site 675635017344 catalytic residue [active] 675635017345 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 675635017346 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 675635017347 ATP-grasp domain; Region: ATP-grasp_4; cl17255 675635017348 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 675635017349 ParB-like nuclease domain; Region: ParBc; pfam02195 675635017350 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635017351 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635017352 P-loop; other site 675635017353 Magnesium ion binding site [ion binding]; other site 675635017354 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635017355 Magnesium ion binding site [ion binding]; other site 675635017356 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 675635017357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635017358 S-adenosylmethionine binding site [chemical binding]; other site 675635017359 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 675635017360 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 675635017361 G-X-X-G motif; other site 675635017362 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 675635017363 RxxxH motif; other site 675635017364 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 675635017365 Haemolytic domain; Region: Haemolytic; pfam01809 675635017366 Ribonuclease P; Region: Ribonuclease_P; cl00457 675635017367 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 675635017368 D5 N terminal like; Region: D5_N; smart00885 675635017369 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 675635017370 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 675635017371 ParA-like protein; Provisional; Region: PHA02518 675635017372 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635017373 P-loop; other site 675635017374 Magnesium ion binding site [ion binding]; other site 675635017375 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 675635017376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 675635017377 Walker A motif; other site 675635017378 ATP binding site [chemical binding]; other site 675635017379 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 675635017380 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 675635017381 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635017382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635017383 S-adenosylmethionine binding site [chemical binding]; other site 675635017384 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 675635017385 ParB-like nuclease domain; Region: ParB; smart00470 675635017386 KorB domain; Region: KorB; pfam08535 675635017387 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635017388 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635017389 P-loop; other site 675635017390 Magnesium ion binding site [ion binding]; other site 675635017391 Homeodomain-like domain; Region: HTH_23; cl17451 675635017392 Winged helix-turn helix; Region: HTH_29; pfam13551 675635017393 Homeodomain-like domain; Region: HTH_32; pfam13565 675635017394 Integrase core domain; Region: rve; pfam00665 675635017395 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 675635017396 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 675635017397 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635017398 F420H2 dehydrogenase subunit FpoO; Region: FpoO; pfam10621 675635017399 MULE transposase domain; Region: MULE; pfam10551 675635017400 Cation efflux family; Region: Cation_efflux; cl00316 675635017401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635017402 dimerization interface [polypeptide binding]; other site 675635017403 putative DNA binding site [nucleotide binding]; other site 675635017404 putative Zn2+ binding site [ion binding]; other site 675635017405 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 675635017406 multiple promoter invertase; Provisional; Region: mpi; PRK13413 675635017407 catalytic residues [active] 675635017408 catalytic nucleophile [active] 675635017409 Presynaptic Site I dimer interface [polypeptide binding]; other site 675635017410 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 675635017411 Synaptic Flat tetramer interface [polypeptide binding]; other site 675635017412 Synaptic Site I dimer interface [polypeptide binding]; other site 675635017413 DNA binding site [nucleotide binding] 675635017414 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 675635017415 DNA-binding interface [nucleotide binding]; DNA binding site 675635017416 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635017417 F420H2 dehydrogenase subunit FpoO; Region: FpoO; pfam10621 675635017418 MULE transposase domain; Region: MULE; pfam10551 675635017419 mercuric reductase; Validated; Region: PRK06370 675635017420 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 675635017421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635017422 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635017423 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 675635017424 putative active site [active] 675635017425 redox center [active] 675635017426 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 675635017427 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 675635017428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635017429 dimerization interface [polypeptide binding]; other site 675635017430 putative DNA binding site [nucleotide binding]; other site 675635017431 putative Zn2+ binding site [ion binding]; other site 675635017432 mercuric reductase; Region: MerA; TIGR02053 675635017433 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635017434 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 675635017435 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635017436 active site 675635017437 DNA binding site [nucleotide binding] 675635017438 Int/Topo IB signature motif; other site 675635017439 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635017440 Amidase; Region: Amidase; pfam01425 675635017441 pyrimidine utilization protein A; Region: RutA; TIGR03612 675635017442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 675635017443 transcriptional regulator NanR; Provisional; Region: PRK03837 675635017444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635017445 DNA-binding site [nucleotide binding]; DNA binding site 675635017446 FCD domain; Region: FCD; pfam07729 675635017447 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 675635017448 putative active site [active] 675635017449 putative catalytic site [active] 675635017450 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635017451 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635017452 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 675635017453 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635017454 active site 675635017455 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 675635017456 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 675635017457 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 675635017458 Amidase; Region: Amidase; pfam01425 675635017459 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 675635017460 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 675635017461 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 675635017462 Plasma-membrane choline transporter; Region: Choline_transpo; pfam04515 675635017463 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 675635017464 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 675635017465 Walker A motif; other site 675635017466 ATP binding site [chemical binding]; other site 675635017467 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 675635017468 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635017469 NlpC/P60 family; Region: NLPC_P60; cl17555 675635017470 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 675635017471 Right handed beta helix region; Region: Beta_helix; pfam13229 675635017472 AAA-like domain; Region: AAA_10; pfam12846 675635017473 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 675635017474 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 675635017475 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 675635017476 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 675635017477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 675635017478 active site 675635017479 phosphorylation site [posttranslational modification] 675635017480 intermolecular recognition site; other site 675635017481 dimerization interface [polypeptide binding]; other site 675635017482 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 675635017483 DNA binding residues [nucleotide binding] 675635017484 dimerization interface [polypeptide binding]; other site 675635017485 PAS domain; Region: PAS; smart00091 675635017486 PAS domain S-box; Region: sensory_box; TIGR00229 675635017487 putative active site [active] 675635017488 heme pocket [chemical binding]; other site 675635017489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 675635017490 Histidine kinase; Region: HisKA_3; pfam07730 675635017491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 675635017492 ATP binding site [chemical binding]; other site 675635017493 Mg2+ binding site [ion binding]; other site 675635017494 G-X-G motif; other site 675635017495 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 675635017496 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 675635017497 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 675635017498 active site 675635017499 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 675635017500 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 675635017501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 675635017502 NAD(P) binding site [chemical binding]; other site 675635017503 active site 675635017504 enoyl-CoA hydratase; Provisional; Region: PRK06563 675635017505 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635017506 substrate binding site [chemical binding]; other site 675635017507 oxyanion hole (OAH) forming residues; other site 675635017508 trimer interface [polypeptide binding]; other site 675635017509 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635017510 substrate binding site [chemical binding]; other site 675635017511 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 675635017512 oxyanion hole (OAH) forming residues; other site 675635017513 trimer interface [polypeptide binding]; other site 675635017514 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 675635017515 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 675635017516 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 675635017517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635017518 D-galactonate transporter; Region: 2A0114; TIGR00893 675635017519 putative substrate translocation pore; other site 675635017520 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 675635017521 putative active site [active] 675635017522 putative catalytic site [active] 675635017523 AMP-binding domain protein; Validated; Region: PRK07529 675635017524 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635017525 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635017526 active site 675635017527 CoA binding site [chemical binding]; other site 675635017528 AMP binding site [chemical binding]; other site 675635017529 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 675635017530 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 675635017531 dimer interface [polypeptide binding]; other site 675635017532 active site 675635017533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 675635017534 Transposase; Region: HTH_Tnp_1; pfam01527 675635017535 putative transposase OrfB; Reviewed; Region: PHA02517 675635017536 HTH-like domain; Region: HTH_21; pfam13276 675635017537 Integrase core domain; Region: rve; pfam00665 675635017538 Integrase core domain; Region: rve_3; pfam13683 675635017539 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 675635017540 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635017541 active site 675635017542 NAD binding site [chemical binding]; other site 675635017543 metal binding site [ion binding]; metal-binding site 675635017544 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635017545 FAD binding domain; Region: FAD_binding_4; pfam01565 675635017546 Transcriptional regulators [Transcription]; Region: FadR; COG2186 675635017547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635017548 DNA-binding site [nucleotide binding]; DNA binding site 675635017549 FCD domain; Region: FCD; pfam07729 675635017550 putative CoA-transferase; Provisional; Region: PRK11430 675635017551 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635017552 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 675635017553 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 675635017554 trimer interface [polypeptide binding]; other site 675635017555 putative metal binding site [ion binding]; other site 675635017556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635017557 Walker A motif; other site 675635017558 ATP binding site [chemical binding]; other site 675635017559 Walker B motif; other site 675635017560 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 675635017561 CoA-transferase family III; Region: CoA_transf_3; pfam02515 675635017562 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 675635017563 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 675635017564 substrate binding site [chemical binding]; other site 675635017565 oxyanion hole (OAH) forming residues; other site 675635017566 trimer interface [polypeptide binding]; other site 675635017567 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 675635017568 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635017569 FAD binding domain; Region: FAD_binding_4; pfam01565 675635017570 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 675635017571 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 675635017572 active site 675635017573 DNA binding site [nucleotide binding] 675635017574 Int/Topo IB signature motif; other site 675635017575 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 675635017576 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 675635017577 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 675635017578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 675635017579 non-specific DNA binding site [nucleotide binding]; other site 675635017580 salt bridge; other site 675635017581 sequence-specific DNA binding site [nucleotide binding]; other site 675635017582 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 675635017583 Domain of unknown function (DUF955); Region: DUF955; cl01076 675635017584 ParB-like nuclease domain; Region: ParB; smart00470 675635017585 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 675635017586 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 675635017587 dimer interface [polypeptide binding]; other site 675635017588 ssDNA binding site [nucleotide binding]; other site 675635017589 tetramer (dimer of dimers) interface [polypeptide binding]; other site 675635017590 Transcription factor WhiB; Region: Whib; pfam02467 675635017591 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 675635017592 polymerase nucleotide-binding site; other site 675635017593 DNA-binding residues [nucleotide binding]; DNA binding site 675635017594 nucleotide binding site [chemical binding]; other site 675635017595 primase nucleotide-binding site [nucleotide binding]; other site 675635017596 DNA protecting protein DprA; Region: dprA; TIGR00732 675635017597 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 675635017598 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635017599 active site residue [active] 675635017600 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 675635017601 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 675635017602 Multicopper oxidase; Region: Cu-oxidase; pfam00394 675635017603 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 675635017604 Predicted membrane protein [Function unknown]; Region: COG3462 675635017605 Short C-terminal domain; Region: SHOCT; pfam09851 675635017606 Domain of unknown function DUF302; Region: DUF302; cl01364 675635017607 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 675635017608 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 675635017609 active site residue [active] 675635017610 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 675635017611 active site residue [active] 675635017612 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 675635017613 putative homodimer interface [polypeptide binding]; other site 675635017614 putative homotetramer interface [polypeptide binding]; other site 675635017615 putative allosteric switch controlling residues; other site 675635017616 putative metal binding site [ion binding]; other site 675635017617 putative homodimer-homodimer interface [polypeptide binding]; other site 675635017618 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635017619 F420H2 dehydrogenase subunit FpoO; Region: FpoO; pfam10621 675635017620 MULE transposase domain; Region: MULE; pfam10551 675635017621 Homeodomain-like domain; Region: HTH_23; cl17451 675635017622 Winged helix-turn helix; Region: HTH_29; pfam13551 675635017623 Homeodomain-like domain; Region: HTH_32; pfam13565 675635017624 Integrase core domain; Region: rve; pfam00665 675635017625 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 675635017626 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 675635017627 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 675635017628 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 675635017629 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 675635017630 NADH dehydrogenase; Region: NADHdh; cl00469 675635017631 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 675635017632 Domain of unknown function (DUF305); Region: DUF305; pfam03713 675635017633 High-affinity nickel-transport protein; Region: NicO; cl00964 675635017634 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 675635017635 putative homodimer interface [polypeptide binding]; other site 675635017636 putative homotetramer interface [polypeptide binding]; other site 675635017637 putative allosteric switch controlling residues; other site 675635017638 putative metal binding site [ion binding]; other site 675635017639 putative homodimer-homodimer interface [polypeptide binding]; other site 675635017640 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635017641 metal-binding site [ion binding] 675635017642 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 675635017643 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 675635017644 metal-binding site [ion binding] 675635017645 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 675635017646 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635017647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635017648 S-adenosylmethionine binding site [chemical binding]; other site 675635017649 S-adenosylmethionine synthetase; Validated; Region: PRK05250 675635017650 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 675635017651 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 675635017652 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 675635017653 Methyltransferase domain; Region: Methyltransf_23; pfam13489 675635017654 Methyltransferase domain; Region: Methyltransf_11; pfam08241 675635017655 S-adenosylmethionine binding site [chemical binding]; other site 675635017656 Fic/DOC family; Region: Fic; cl00960 675635017657 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 675635017658 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 675635017659 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 675635017660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635017661 sequence-specific DNA binding site [nucleotide binding]; other site 675635017662 salt bridge; other site 675635017663 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635017664 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 675635017665 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635017666 active site 675635017667 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 675635017668 Right handed beta helix region; Region: Beta_helix; pfam13229 675635017669 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635017670 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 675635017671 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 675635017672 acyl-activating enzyme (AAE) consensus motif; other site 675635017673 acyl-activating enzyme (AAE) consensus motif; other site 675635017674 AMP binding site [chemical binding]; other site 675635017675 active site 675635017676 CoA binding site [chemical binding]; other site 675635017677 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635017678 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 675635017679 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635017680 Walker A/P-loop; other site 675635017681 ATP binding site [chemical binding]; other site 675635017682 Q-loop/lid; other site 675635017683 ABC transporter signature motif; other site 675635017684 Walker B; other site 675635017685 D-loop; other site 675635017686 H-loop/switch region; other site 675635017687 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 675635017688 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 675635017689 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 675635017690 Walker A/P-loop; other site 675635017691 ATP binding site [chemical binding]; other site 675635017692 Q-loop/lid; other site 675635017693 ABC transporter signature motif; other site 675635017694 Walker B; other site 675635017695 D-loop; other site 675635017696 H-loop/switch region; other site 675635017697 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 675635017698 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 675635017699 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 675635017700 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 675635017701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635017702 putative PBP binding loops; other site 675635017703 dimer interface [polypeptide binding]; other site 675635017704 ABC-ATPase subunit interface; other site 675635017705 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 675635017706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 675635017707 dimer interface [polypeptide binding]; other site 675635017708 conserved gate region; other site 675635017709 putative PBP binding loops; other site 675635017710 ABC-ATPase subunit interface; other site 675635017711 Amidohydrolase; Region: Amidohydro_2; pfam04909 675635017712 Transcriptional regulators [Transcription]; Region: PurR; COG1609 675635017713 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 675635017714 DNA binding site [nucleotide binding] 675635017715 domain linker motif; other site 675635017716 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 675635017717 dimerization interface [polypeptide binding]; other site 675635017718 ligand binding site [chemical binding]; other site 675635017719 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 675635017720 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635017721 Protein of unknown function (DUF993); Region: DUF993; pfam06187 675635017722 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 675635017723 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 675635017724 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 675635017725 active site 675635017726 metal binding site [ion binding]; metal-binding site 675635017727 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 675635017728 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 675635017729 nucleotide binding site [chemical binding]; other site 675635017730 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 675635017731 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 675635017732 iron-sulfur cluster [ion binding]; other site 675635017733 [2Fe-2S] cluster binding site [ion binding]; other site 675635017734 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 675635017735 metabolite-proton symporter; Region: 2A0106; TIGR00883 675635017736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 675635017737 putative substrate translocation pore; other site 675635017738 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 675635017739 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 675635017740 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 675635017741 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 675635017742 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 675635017743 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 675635017744 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 675635017745 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 675635017746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 675635017747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 675635017748 Restriction endonuclease; Region: Mrr_cat; pfam04471 675635017749 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635017750 MULE transposase domain; Region: MULE; pfam10551 675635017751 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 675635017752 Helix-turn-helix; Region: HTH_3; pfam01381 675635017753 sequence-specific DNA binding site [nucleotide binding]; other site 675635017754 salt bridge; other site 675635017755 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 675635017756 NlpC/P60 family; Region: NLPC_P60; pfam00877 675635017757 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 675635017758 polymerase nucleotide-binding site; other site 675635017759 DNA-binding residues [nucleotide binding]; DNA binding site 675635017760 nucleotide binding site [chemical binding]; other site 675635017761 primase nucleotide-binding site [nucleotide binding]; other site 675635017762 Helix-turn-helix domain; Region: HTH_36; pfam13730 675635017763 replicative DNA helicase; Region: DnaB; TIGR00665 675635017764 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 675635017765 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 675635017766 Walker A motif; other site 675635017767 ATP binding site [chemical binding]; other site 675635017768 Walker B motif; other site 675635017769 DNA binding loops [nucleotide binding] 675635017770 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635017771 MULE transposase domain; Region: MULE; pfam10551 675635017772 Zeta toxin; Region: Zeta_toxin; pfam06414 675635017773 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 675635017774 active site 675635017775 catalytic residues [active] 675635017776 DNA binding site [nucleotide binding] 675635017777 Int/Topo IB signature motif; other site 675635017778 Transposase, Mutator family; Region: Transposase_mut; pfam00872 675635017779 MULE transposase domain; Region: MULE; pfam10551 675635017780 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 675635017781 FAD binding domain; Region: FAD_binding_4; pfam01565 675635017782 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 675635017783 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 675635017784 Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190 675635017785 putative active site [active] 675635017786 metal binding site [ion binding]; metal-binding site 675635017787 Transcriptional regulators [Transcription]; Region: GntR; COG1802 675635017788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 675635017789 DNA-binding site [nucleotide binding]; DNA binding site 675635017790 FCD domain; Region: FCD; pfam07729 675635017791 conserved hypothetical protein; Region: TIGR02118 675635017792 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 675635017793 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635017794 NAD(P) binding site [chemical binding]; other site 675635017795 catalytic residues [active] 675635017796 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 675635017797 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 675635017798 catalytic loop [active] 675635017799 iron binding site [ion binding]; other site 675635017800 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 675635017801 FAD binding pocket [chemical binding]; other site 675635017802 FAD binding motif [chemical binding]; other site 675635017803 phosphate binding motif [ion binding]; other site 675635017804 beta-alpha-beta structure motif; other site 675635017805 NAD binding pocket [chemical binding]; other site 675635017806 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 675635017807 dimerization interface [polypeptide binding]; other site 675635017808 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 675635017809 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 675635017810 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 675635017811 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 675635017812 NAD(P) binding site [chemical binding]; other site 675635017813 catalytic residues [active] 675635017814 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 675635017815 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 675635017816 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635017817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635017818 Vps51/Vps67; Region: Vps51; pfam08700 675635017819 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635017820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 675635017821 Integrase core domain; Region: rve; pfam00665 675635017822 transposase/IS protein; Provisional; Region: PRK09183 675635017823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 675635017824 Walker A motif; other site 675635017825 ATP binding site [chemical binding]; other site 675635017826 Walker B motif; other site 675635017827 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635017828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 675635017829 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635017830 Transposase; Region: DEDD_Tnp_IS110; pfam01548 675635017831 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 675635017832 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 675635017833 ParB-like nuclease domain; Region: ParB; smart00470 675635017834 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 675635017835 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 675635017836 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 675635017837 Magnesium ion binding site [ion binding]; other site 675635017838 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 675635017839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 675635017840 non-specific DNA binding site [nucleotide binding]; other site 675635017841 salt bridge; other site 675635017842 sequence-specific DNA binding site [nucleotide binding]; other site 675635017843 Transcription factor WhiB; Region: Whib; pfam02467 675635017844 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 675635017845 dimerization interface [polypeptide binding]; other site 675635017846 putative DNA binding site [nucleotide binding]; other site 675635017847 putative Zn2+ binding site [ion binding]; other site 675635017848 Transcription factor WhiB; Region: Whib; pfam02467 675635017849 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 675635017850 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 675635017851 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 675635017852 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 675635017853 cofactor binding site; other site 675635017854 DNA binding site [nucleotide binding] 675635017855 substrate interaction site [chemical binding]; other site 675635017856 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 675635017857 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 675635017858 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 675635017859 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 675635017860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 675635017861 S-adenosylmethionine binding site [chemical binding]; other site 675635017862 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 675635017863 DEAD-like helicases superfamily; Region: DEXDc; smart00487 675635017864 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 675635017865 helicase superfamily c-terminal domain; Region: HELICc; smart00490 675635017866 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 675635017867 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 675635017868 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 675635017869 AAA-like domain; Region: AAA_10; pfam12846