-- dump date 20140620_020559 -- class Genbank::misc_feature -- table misc_feature_note -- id note 911045000001 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 911045000002 Peptidase family M23; Region: Peptidase_M23; pfam01551 911045000003 AAA domain; Region: AAA_18; pfam13238 911045000004 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 911045000005 active site 911045000006 Protein of unknown function (DUF998); Region: DUF998; pfam06197 911045000007 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 911045000008 Clp amino terminal domain; Region: Clp_N; pfam02861 911045000009 Clp amino terminal domain; Region: Clp_N; pfam02861 911045000010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045000011 Walker A motif; other site 911045000012 ATP binding site [chemical binding]; other site 911045000013 Walker B motif; other site 911045000014 arginine finger; other site 911045000015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045000016 Walker A motif; other site 911045000017 ATP binding site [chemical binding]; other site 911045000018 Walker B motif; other site 911045000019 arginine finger; other site 911045000020 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 911045000021 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 911045000022 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 911045000023 MOSC domain; Region: MOSC; pfam03473 911045000024 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 911045000025 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 911045000026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000027 S-adenosylmethionine binding site [chemical binding]; other site 911045000028 peptide chain release factor 1; Validated; Region: prfA; PRK00591 911045000029 This domain is found in peptide chain release factors; Region: PCRF; smart00937 911045000030 RF-1 domain; Region: RF-1; pfam00472 911045000031 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 911045000032 GAF domain; Region: GAF; pfam01590 911045000033 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 911045000034 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 911045000035 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 911045000036 aspartate kinase; Reviewed; Region: PRK06635 911045000037 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 911045000038 putative nucleotide binding site [chemical binding]; other site 911045000039 putative catalytic residues [active] 911045000040 putative Mg ion binding site [ion binding]; other site 911045000041 putative aspartate binding site [chemical binding]; other site 911045000042 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 911045000043 putative allosteric regulatory site; other site 911045000044 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 911045000045 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 911045000046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000047 S-adenosylmethionine binding site [chemical binding]; other site 911045000048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045000049 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 911045000050 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 911045000051 nitrilase; Region: PLN02798 911045000052 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 911045000053 putative active site [active] 911045000054 catalytic triad [active] 911045000055 dimer interface [polypeptide binding]; other site 911045000056 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 911045000057 GSH binding site [chemical binding]; other site 911045000058 catalytic residues [active] 911045000059 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 911045000060 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045000061 active site 911045000062 Methyltransferase domain; Region: Methyltransf_23; pfam13489 911045000063 Methyltransferase domain; Region: Methyltransf_11; pfam08241 911045000064 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 911045000065 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 911045000066 active site 911045000067 8-oxo-dGMP binding site [chemical binding]; other site 911045000068 nudix motif; other site 911045000069 metal binding site [ion binding]; metal-binding site 911045000070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045000071 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045000072 Coenzyme A binding pocket [chemical binding]; other site 911045000073 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 911045000074 heterotetramer interface [polypeptide binding]; other site 911045000075 active site pocket [active] 911045000076 cleavage site 911045000077 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 911045000078 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 911045000079 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 911045000080 SEC-C motif; Region: SEC-C; pfam02810 911045000081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000082 S-adenosylmethionine binding site [chemical binding]; other site 911045000083 Predicted transcriptional regulators [Transcription]; Region: COG1695 911045000084 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 911045000085 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 911045000086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 911045000087 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 911045000088 PGAP1-like protein; Region: PGAP1; pfam07819 911045000089 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045000090 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 911045000091 nucleophilic elbow; other site 911045000092 catalytic triad; other site 911045000093 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 911045000094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 911045000095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045000096 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045000097 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045000098 dimer interface [polypeptide binding]; other site 911045000099 putative CheW interface [polypeptide binding]; other site 911045000100 EamA-like transporter family; Region: EamA; pfam00892 911045000101 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045000102 EamA-like transporter family; Region: EamA; pfam00892 911045000103 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 911045000104 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045000105 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045000106 active site 911045000107 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 911045000108 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 911045000109 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 911045000110 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045000111 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 911045000112 active site 911045000113 catalytic tetrad [active] 911045000114 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 911045000115 active site 911045000116 catalytic triad [active] 911045000117 oxyanion hole [active] 911045000118 switch loop; other site 911045000119 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 911045000120 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 911045000121 Walker A/P-loop; other site 911045000122 ATP binding site [chemical binding]; other site 911045000123 Q-loop/lid; other site 911045000124 ABC transporter signature motif; other site 911045000125 Walker B; other site 911045000126 D-loop; other site 911045000127 H-loop/switch region; other site 911045000128 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 911045000129 FtsX-like permease family; Region: FtsX; pfam02687 911045000130 FtsX-like permease family; Region: FtsX; pfam02687 911045000131 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 911045000132 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 911045000133 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 911045000134 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 911045000135 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045000136 GAF domain; Region: GAF; cl17456 911045000137 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045000138 dimerization interface [polypeptide binding]; other site 911045000139 putative DNA binding site [nucleotide binding]; other site 911045000140 putative Zn2+ binding site [ion binding]; other site 911045000141 Predicted permeases [General function prediction only]; Region: COG0701 911045000142 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 911045000143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045000144 ATP binding site [chemical binding]; other site 911045000145 putative Mg++ binding site [ion binding]; other site 911045000146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045000147 nucleotide binding region [chemical binding]; other site 911045000148 ATP-binding site [chemical binding]; other site 911045000149 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 911045000150 HRDC domain; Region: HRDC; pfam00570 911045000151 Electron transfer DM13; Region: DM13; pfam10517 911045000152 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 911045000153 heme-binding site [chemical binding]; other site 911045000154 CAAX protease self-immunity; Region: Abi; pfam02517 911045000155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045000156 metabolite-proton symporter; Region: 2A0106; TIGR00883 911045000157 putative substrate translocation pore; other site 911045000158 cystathionine gamma-lyase; Validated; Region: PRK07582 911045000159 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045000160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045000161 catalytic residue [active] 911045000162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045000163 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045000164 putative substrate translocation pore; other site 911045000165 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 911045000166 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 911045000167 dimer interface [polypeptide binding]; other site 911045000168 substrate binding site [chemical binding]; other site 911045000169 metal binding sites [ion binding]; metal-binding site 911045000170 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 911045000171 Predicted membrane protein [Function unknown]; Region: COG1238 911045000172 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 911045000173 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045000174 active site 911045000175 DNA binding site [nucleotide binding] 911045000176 Int/Topo IB signature motif; other site 911045000177 shikimate kinase; Provisional; Region: PRK13946 911045000178 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 911045000179 ADP binding site [chemical binding]; other site 911045000180 magnesium binding site [ion binding]; other site 911045000181 putative shikimate binding site; other site 911045000182 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 911045000183 active site 911045000184 dimer interface [polypeptide binding]; other site 911045000185 metal binding site [ion binding]; metal-binding site 911045000186 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 911045000187 Domain of unknown function DUF21; Region: DUF21; pfam01595 911045000188 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 911045000189 Transporter associated domain; Region: CorC_HlyC; smart01091 911045000190 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 911045000191 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 911045000192 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 911045000193 HSP70 interaction site [polypeptide binding]; other site 911045000194 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 911045000195 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 911045000196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 911045000197 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 911045000198 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 911045000199 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 911045000200 metal ion-dependent adhesion site (MIDAS); other site 911045000201 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 911045000202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 911045000203 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 911045000204 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 911045000205 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 911045000206 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 911045000207 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 911045000208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 911045000209 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 911045000210 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 911045000211 Protein of unknown function (DUF429); Region: DUF429; cl12046 911045000212 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 911045000213 dimer interface [polypeptide binding]; other site 911045000214 pyridoxamine kinase; Validated; Region: PRK05756 911045000215 pyridoxal binding site [chemical binding]; other site 911045000216 ATP binding site [chemical binding]; other site 911045000217 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 911045000218 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 911045000219 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 911045000220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000221 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 911045000222 NAD(P) binding site [chemical binding]; other site 911045000223 active site 911045000224 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 911045000225 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 911045000226 active site 911045000227 nucleophile elbow; other site 911045000228 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 911045000229 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 911045000230 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 911045000231 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 911045000232 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 911045000233 Uncharacterized conserved protein [Function unknown]; Region: COG4121 911045000234 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045000235 YGGT family; Region: YGGT; pfam02325 911045000236 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 911045000237 Uncharacterized conserved protein [Function unknown]; Region: COG2835 911045000238 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 911045000239 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 911045000240 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 911045000241 catalytic residues [active] 911045000242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 911045000243 binding surface 911045000244 TPR motif; other site 911045000245 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 911045000246 putative deacylase active site [active] 911045000247 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 911045000248 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 911045000249 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 911045000250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 911045000251 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 911045000252 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 911045000253 putative active site [active] 911045000254 putative PHP Thumb interface [polypeptide binding]; other site 911045000255 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 911045000256 generic binding surface I; other site 911045000257 generic binding surface II; other site 911045000258 DNA Polymerase Y-family; Region: PolY_like; cd03468 911045000259 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 911045000260 DNA binding site [nucleotide binding] 911045000261 Uncharacterized conserved protein [Function unknown]; Region: COG4544 911045000262 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 911045000263 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 911045000264 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 911045000265 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 911045000266 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 911045000267 active site 911045000268 acyl-activating enzyme (AAE) consensus motif; other site 911045000269 putative CoA binding site [chemical binding]; other site 911045000270 AMP binding site [chemical binding]; other site 911045000271 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 911045000272 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 911045000273 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 911045000274 Walker A/P-loop; other site 911045000275 ATP binding site [chemical binding]; other site 911045000276 Q-loop/lid; other site 911045000277 ABC transporter signature motif; other site 911045000278 Walker B; other site 911045000279 D-loop; other site 911045000280 H-loop/switch region; other site 911045000281 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 911045000282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045000283 dimer interface [polypeptide binding]; other site 911045000284 conserved gate region; other site 911045000285 putative PBP binding loops; other site 911045000286 ABC-ATPase subunit interface; other site 911045000287 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 911045000288 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 911045000289 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 911045000290 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 911045000291 putative NAD(P) binding site [chemical binding]; other site 911045000292 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 911045000293 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 911045000294 B12 binding site [chemical binding]; other site 911045000295 cobalt ligand [ion binding]; other site 911045000296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045000297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045000298 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045000299 putative effector binding pocket; other site 911045000300 dimerization interface [polypeptide binding]; other site 911045000301 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 911045000302 Bacterial SH3 domain; Region: SH3_3; pfam08239 911045000303 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 911045000304 active site 911045000305 putative catalytic site [active] 911045000306 metal binding site A [ion binding]; metal-binding site 911045000307 putative phosphate binding site [ion binding]; other site 911045000308 DNA binding site [nucleotide binding] 911045000309 putative AP binding site [nucleotide binding]; other site 911045000310 putative metal binding site B [ion binding]; other site 911045000311 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 911045000312 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 911045000313 NAD(P) binding site [chemical binding]; other site 911045000314 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 911045000315 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 911045000316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045000317 FeS/SAM binding site; other site 911045000318 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 911045000319 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 911045000320 TM2 domain; Region: TM2; pfam05154 911045000321 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 911045000322 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045000323 Soluble P-type ATPase [General function prediction only]; Region: COG4087 911045000324 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045000325 MarR family; Region: MarR; pfam01047 911045000326 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 911045000327 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 911045000328 catalytic center binding site [active] 911045000329 ATP binding site [chemical binding]; other site 911045000330 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 911045000331 dihydropteroate synthase; Region: DHPS; TIGR01496 911045000332 substrate binding pocket [chemical binding]; other site 911045000333 dimer interface [polypeptide binding]; other site 911045000334 inhibitor binding site; inhibition site 911045000335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045000336 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045000337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045000338 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 911045000339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045000340 putative substrate translocation pore; other site 911045000341 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 911045000342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045000343 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045000344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045000345 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 911045000346 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 911045000347 G1 box; other site 911045000348 putative GEF interaction site [polypeptide binding]; other site 911045000349 GTP/Mg2+ binding site [chemical binding]; other site 911045000350 Switch I region; other site 911045000351 G2 box; other site 911045000352 G3 box; other site 911045000353 Switch II region; other site 911045000354 G4 box; other site 911045000355 G5 box; other site 911045000356 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 911045000357 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 911045000358 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 911045000359 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 911045000360 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 911045000361 E-class dimer interface [polypeptide binding]; other site 911045000362 P-class dimer interface [polypeptide binding]; other site 911045000363 active site 911045000364 Cu2+ binding site [ion binding]; other site 911045000365 Zn2+ binding site [ion binding]; other site 911045000366 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 911045000367 prephenate dehydrogenase; Validated; Region: PRK08507 911045000368 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 911045000369 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045000370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045000371 homodimer interface [polypeptide binding]; other site 911045000372 catalytic residue [active] 911045000373 hypothetical protein; Provisional; Region: PRK06034 911045000374 Chorismate mutase type II; Region: CM_2; cl00693 911045000375 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 911045000376 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 911045000377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000378 S-adenosylmethionine binding site [chemical binding]; other site 911045000379 Methyltransferase domain; Region: Methyltransf_11; pfam08241 911045000380 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 911045000381 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 911045000382 argininosuccinate synthase; Provisional; Region: PRK13820 911045000383 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 911045000384 ANP binding site [chemical binding]; other site 911045000385 Substrate Binding Site II [chemical binding]; other site 911045000386 Substrate Binding Site I [chemical binding]; other site 911045000387 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 911045000388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000389 S-adenosylmethionine binding site [chemical binding]; other site 911045000390 MAPEG family; Region: MAPEG; pfam01124 911045000391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 911045000392 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 911045000393 Amino acid permease; Region: AA_permease_2; pfam13520 911045000394 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 911045000395 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 911045000396 homodimer interface [polypeptide binding]; other site 911045000397 substrate-cofactor binding pocket; other site 911045000398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045000399 catalytic residue [active] 911045000400 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 911045000401 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 911045000402 trimer interface [polypeptide binding]; other site 911045000403 active site 911045000404 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 911045000405 trimer interface [polypeptide binding]; other site 911045000406 active site 911045000407 Uncharacterized conserved protein [Function unknown]; Region: COG1739 911045000408 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 911045000409 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 911045000410 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 911045000411 Domain of unknown function (DUF336); Region: DUF336; cl01249 911045000412 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 911045000413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045000414 motif II; other site 911045000415 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 911045000416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 911045000417 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 911045000418 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 911045000419 putative acyltransferase; Provisional; Region: PRK05790 911045000420 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 911045000421 dimer interface [polypeptide binding]; other site 911045000422 active site 911045000423 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 911045000424 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 911045000425 NAD(P) binding site [chemical binding]; other site 911045000426 homotetramer interface [polypeptide binding]; other site 911045000427 homodimer interface [polypeptide binding]; other site 911045000428 active site 911045000429 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045000430 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 911045000431 Transglycosylase; Region: Transgly; pfam00912 911045000432 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 911045000433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045000434 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 911045000435 dimerization interface [polypeptide binding]; other site 911045000436 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 911045000437 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 911045000438 dimer interface [polypeptide binding]; other site 911045000439 decamer (pentamer of dimers) interface [polypeptide binding]; other site 911045000440 catalytic triad [active] 911045000441 peroxidatic and resolving cysteines [active] 911045000442 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 911045000443 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 911045000444 TM2 domain; Region: TM2; cl00984 911045000445 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 911045000446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000447 S-adenosylmethionine binding site [chemical binding]; other site 911045000448 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 911045000449 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 911045000450 substrate binding pocket [chemical binding]; other site 911045000451 chain length determination region; other site 911045000452 substrate-Mg2+ binding site; other site 911045000453 catalytic residues [active] 911045000454 aspartate-rich region 1; other site 911045000455 active site lid residues [active] 911045000456 aspartate-rich region 2; other site 911045000457 Isochorismatase family; Region: Isochorismatase; pfam00857 911045000458 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 911045000459 catalytic triad [active] 911045000460 conserved cis-peptide bond; other site 911045000461 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 911045000462 putative deacylase active site [active] 911045000463 Predicted esterase [General function prediction only]; Region: COG0400 911045000464 putative hydrolase; Provisional; Region: PRK11460 911045000465 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 911045000466 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 911045000467 helix-hairpin-helix signature motif; other site 911045000468 substrate binding pocket [chemical binding]; other site 911045000469 active site 911045000470 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 911045000471 active site 911045000472 HIGH motif; other site 911045000473 nucleotide binding site [chemical binding]; other site 911045000474 active site 911045000475 KMSKS motif; other site 911045000476 Predicted permeases [General function prediction only]; Region: COG0679 911045000477 Predicted permeases [General function prediction only]; Region: COG0679 911045000478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045000479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045000480 dimer interface [polypeptide binding]; other site 911045000481 phosphorylation site [posttranslational modification] 911045000482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045000483 ATP binding site [chemical binding]; other site 911045000484 Mg2+ binding site [ion binding]; other site 911045000485 G-X-G motif; other site 911045000486 Response regulator receiver domain; Region: Response_reg; pfam00072 911045000487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045000488 active site 911045000489 phosphorylation site [posttranslational modification] 911045000490 intermolecular recognition site; other site 911045000491 dimerization interface [polypeptide binding]; other site 911045000492 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 911045000493 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 911045000494 putative catalytic residue [active] 911045000495 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 911045000496 active site 911045000497 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 911045000498 Low molecular weight phosphatase family; Region: LMWPc; cd00115 911045000499 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 911045000500 aromatic arch; other site 911045000501 DCoH dimer interaction site [polypeptide binding]; other site 911045000502 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 911045000503 DCoH tetramer interaction site [polypeptide binding]; other site 911045000504 substrate binding site [chemical binding]; other site 911045000505 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 911045000506 CPxP motif; other site 911045000507 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 911045000508 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 911045000509 Nitrogen regulatory protein P-II; Region: P-II; smart00938 911045000510 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 911045000511 SnoaL-like domain; Region: SnoaL_2; pfam12680 911045000512 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045000513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045000514 dimer interface [polypeptide binding]; other site 911045000515 conserved gate region; other site 911045000516 putative PBP binding loops; other site 911045000517 ABC-ATPase subunit interface; other site 911045000518 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 911045000519 Cation efflux family; Region: Cation_efflux; pfam01545 911045000520 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 911045000521 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 911045000522 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 911045000523 catalytic residues [active] 911045000524 central insert; other site 911045000525 heme exporter protein CcmC; Region: ccmC; TIGR01191 911045000526 heme exporter protein CcmB; Region: ccmB; TIGR01190 911045000527 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 911045000528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045000529 Walker A/P-loop; other site 911045000530 ATP binding site [chemical binding]; other site 911045000531 Q-loop/lid; other site 911045000532 ABC transporter signature motif; other site 911045000533 Walker B; other site 911045000534 D-loop; other site 911045000535 H-loop/switch region; other site 911045000536 Cupin domain; Region: Cupin_2; pfam07883 911045000537 aconitate hydratase; Validated; Region: PRK09277 911045000538 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 911045000539 substrate binding site [chemical binding]; other site 911045000540 ligand binding site [chemical binding]; other site 911045000541 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 911045000542 substrate binding site [chemical binding]; other site 911045000543 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 911045000544 active site 911045000545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045000546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045000547 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045000548 putative effector binding pocket; other site 911045000549 dimerization interface [polypeptide binding]; other site 911045000550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000551 NADH(P)-binding; Region: NAD_binding_10; pfam13460 911045000552 NAD(P) binding site [chemical binding]; other site 911045000553 active site 911045000554 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045000555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045000556 Coenzyme A binding pocket [chemical binding]; other site 911045000557 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 911045000558 active site clefts [active] 911045000559 zinc binding site [ion binding]; other site 911045000560 dimer interface [polypeptide binding]; other site 911045000561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045000562 Coenzyme A binding pocket [chemical binding]; other site 911045000563 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 911045000564 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 911045000565 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 911045000566 purine monophosphate binding site [chemical binding]; other site 911045000567 dimer interface [polypeptide binding]; other site 911045000568 putative catalytic residues [active] 911045000569 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 911045000570 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 911045000571 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 911045000572 NusB family; Region: NusB; pfam01029 911045000573 putative RNA binding site [nucleotide binding]; other site 911045000574 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 911045000575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045000576 S-adenosylmethionine binding site [chemical binding]; other site 911045000577 heat shock protein HtpX; Provisional; Region: PRK01345 911045000578 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 911045000579 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 911045000580 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 911045000581 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 911045000582 oligomer interface [polypeptide binding]; other site 911045000583 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 911045000584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045000585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045000586 homodimer interface [polypeptide binding]; other site 911045000587 catalytic residue [active] 911045000588 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 911045000589 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 911045000590 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 911045000591 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 911045000592 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 911045000593 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 911045000594 ATP-grasp domain; Region: ATP-grasp_4; cl17255 911045000595 ATP-grasp domain; Region: ATP-grasp_4; cl17255 911045000596 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 911045000597 GTP cyclohydrolase I; Provisional; Region: PLN03044 911045000598 active site 911045000599 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 911045000600 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 911045000601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045000602 Coenzyme A binding pocket [chemical binding]; other site 911045000603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 911045000604 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 911045000605 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 911045000606 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 911045000607 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 911045000608 putative acyl-acceptor binding pocket; other site 911045000609 Uncharacterized conserved protein [Function unknown]; Region: COG1434 911045000610 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 911045000611 putative active site [active] 911045000612 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 911045000613 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 911045000614 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 911045000615 Walker A/P-loop; other site 911045000616 ATP binding site [chemical binding]; other site 911045000617 Q-loop/lid; other site 911045000618 ABC transporter signature motif; other site 911045000619 Walker B; other site 911045000620 D-loop; other site 911045000621 H-loop/switch region; other site 911045000622 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 911045000623 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 911045000624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045000625 active site 911045000626 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 911045000627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045000628 active site 911045000629 phosphorylation site [posttranslational modification] 911045000630 intermolecular recognition site; other site 911045000631 dimerization interface [polypeptide binding]; other site 911045000632 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 911045000633 Active site serine [active] 911045000634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045000635 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 911045000636 diaminopimelate decarboxylase; Region: lysA; TIGR01048 911045000637 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 911045000638 active site 911045000639 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045000640 substrate binding site [chemical binding]; other site 911045000641 catalytic residues [active] 911045000642 dimer interface [polypeptide binding]; other site 911045000643 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 911045000644 argininosuccinate lyase; Provisional; Region: PRK00855 911045000645 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 911045000646 active sites [active] 911045000647 tetramer interface [polypeptide binding]; other site 911045000648 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 911045000649 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 911045000650 catalytic residues [active] 911045000651 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045000652 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 911045000653 putative dimer interface [polypeptide binding]; other site 911045000654 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 911045000655 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 911045000656 active site 911045000657 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 911045000658 catalytic triad [active] 911045000659 dimer interface [polypeptide binding]; other site 911045000660 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 911045000661 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 911045000662 short chain dehydrogenase; Provisional; Region: PRK05993 911045000663 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 911045000664 NADP binding site [chemical binding]; other site 911045000665 active site 911045000666 steroid binding site; other site 911045000667 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045000668 Sel1-like repeats; Region: SEL1; smart00671 911045000669 Sel1-like repeats; Region: SEL1; smart00671 911045000670 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045000671 Sel1-like repeats; Region: SEL1; smart00671 911045000672 Sel1-like repeats; Region: SEL1; smart00671 911045000673 Sel1-like repeats; Region: SEL1; smart00671 911045000674 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045000675 Sel1-like repeats; Region: SEL1; smart00671 911045000676 Sel1-like repeats; Region: SEL1; smart00671 911045000677 Sel1-like repeats; Region: SEL1; smart00671 911045000678 Sel1-like repeats; Region: SEL1; smart00671 911045000679 Sel1-like repeats; Region: SEL1; smart00671 911045000680 DEAD-like helicases superfamily; Region: DEXDc; smart00487 911045000681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045000682 ATP binding site [chemical binding]; other site 911045000683 putative Mg++ binding site [ion binding]; other site 911045000684 helicase superfamily c-terminal domain; Region: HELICc; smart00490 911045000685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045000686 Coenzyme A binding pocket [chemical binding]; other site 911045000687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045000688 putative substrate translocation pore; other site 911045000689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045000690 TspO/MBR family; Region: TspO_MBR; pfam03073 911045000691 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 911045000692 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 911045000693 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 911045000694 Ligand binding site [chemical binding]; other site 911045000695 Electron transfer flavoprotein domain; Region: ETF; pfam01012 911045000696 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 911045000697 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 911045000698 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 911045000699 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 911045000700 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 911045000701 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045000702 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 911045000703 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 911045000704 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 911045000705 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 911045000706 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 911045000707 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045000708 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 911045000709 putative C-terminal domain interface [polypeptide binding]; other site 911045000710 putative GSH binding site (G-site) [chemical binding]; other site 911045000711 putative dimer interface [polypeptide binding]; other site 911045000712 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 911045000713 dimer interface [polypeptide binding]; other site 911045000714 N-terminal domain interface [polypeptide binding]; other site 911045000715 substrate binding pocket (H-site) [chemical binding]; other site 911045000716 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 911045000717 acetyl-CoA synthetase; Provisional; Region: PRK00174 911045000718 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 911045000719 active site 911045000720 CoA binding site [chemical binding]; other site 911045000721 acyl-activating enzyme (AAE) consensus motif; other site 911045000722 AMP binding site [chemical binding]; other site 911045000723 acetate binding site [chemical binding]; other site 911045000724 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 911045000725 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 911045000726 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 911045000727 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 911045000728 active site 911045000729 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 911045000730 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 911045000731 substrate binding site [chemical binding]; other site 911045000732 ligand binding site [chemical binding]; other site 911045000733 phosphodiesterase YaeI; Provisional; Region: PRK11340 911045000734 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 911045000735 putative active site [active] 911045000736 putative metal binding site [ion binding]; other site 911045000737 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 911045000738 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 911045000739 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 911045000740 RimM N-terminal domain; Region: RimM; pfam01782 911045000741 PRC-barrel domain; Region: PRC; pfam05239 911045000742 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 911045000743 chorismate mutase; Provisional; Region: PRK09239 911045000744 signal recognition particle protein; Provisional; Region: PRK10867 911045000745 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 911045000746 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 911045000747 P loop; other site 911045000748 GTP binding site [chemical binding]; other site 911045000749 Signal peptide binding domain; Region: SRP_SPB; pfam02978 911045000750 Esterase/lipase [General function prediction only]; Region: COG1647 911045000751 Esterase/lipase [General function prediction only]; Region: COG1647 911045000752 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 911045000753 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045000754 catalytic residue [active] 911045000755 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 911045000756 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 911045000757 HIGH motif; other site 911045000758 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 911045000759 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045000760 active site 911045000761 KMSKS motif; other site 911045000762 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 911045000763 tRNA binding surface [nucleotide binding]; other site 911045000764 Lipopolysaccharide-assembly; Region: LptE; cl01125 911045000765 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 911045000766 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 911045000767 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 911045000768 ParB-like nuclease domain; Region: ParB; smart00470 911045000769 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 911045000770 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045000771 P-loop; other site 911045000772 Magnesium ion binding site [ion binding]; other site 911045000773 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045000774 Magnesium ion binding site [ion binding]; other site 911045000775 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 911045000776 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 911045000777 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 911045000778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 911045000779 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 911045000780 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 911045000781 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 911045000782 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 911045000783 trmE is a tRNA modification GTPase; Region: trmE; cd04164 911045000784 G1 box; other site 911045000785 GTP/Mg2+ binding site [chemical binding]; other site 911045000786 Switch I region; other site 911045000787 G2 box; other site 911045000788 Switch II region; other site 911045000789 G3 box; other site 911045000790 G4 box; other site 911045000791 G5 box; other site 911045000792 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 911045000793 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 911045000794 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 911045000795 catalytic residues [active] 911045000796 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 911045000797 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045000798 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045000799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045000800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045000801 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045000802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045000803 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045000804 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045000805 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045000806 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045000807 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045000808 transcription termination factor Rho; Provisional; Region: rho; PRK09376 911045000809 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 911045000810 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 911045000811 RNA binding site [nucleotide binding]; other site 911045000812 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 911045000813 multimer interface [polypeptide binding]; other site 911045000814 Walker A motif; other site 911045000815 ATP binding site [chemical binding]; other site 911045000816 Walker B motif; other site 911045000817 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 911045000818 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 911045000819 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 911045000820 substrate binding site [chemical binding]; other site 911045000821 active site 911045000822 PEP synthetase regulatory protein; Provisional; Region: PRK05339 911045000823 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 911045000824 active site 911045000825 dimer interface [polypeptide binding]; other site 911045000826 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 911045000827 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 911045000828 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 911045000829 shikimate binding site; other site 911045000830 NAD(P) binding site [chemical binding]; other site 911045000831 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 911045000832 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 911045000833 CoA-binding site [chemical binding]; other site 911045000834 ATP-binding [chemical binding]; other site 911045000835 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 911045000836 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 911045000837 active site 911045000838 catalytic site [active] 911045000839 substrate binding site [chemical binding]; other site 911045000840 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 911045000841 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 911045000842 dimerization interface [polypeptide binding]; other site 911045000843 ligand binding site [chemical binding]; other site 911045000844 NADP binding site [chemical binding]; other site 911045000845 catalytic site [active] 911045000846 Bacterial SH3 domain; Region: SH3_4; pfam06347 911045000847 Bacterial SH3 domain; Region: SH3_4; pfam06347 911045000848 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 911045000849 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 911045000850 NAD binding site [chemical binding]; other site 911045000851 homotetramer interface [polypeptide binding]; other site 911045000852 homodimer interface [polypeptide binding]; other site 911045000853 substrate binding site [chemical binding]; other site 911045000854 active site 911045000855 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 911045000856 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 911045000857 dimer interface [polypeptide binding]; other site 911045000858 active site 911045000859 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 911045000860 active site 1 [active] 911045000861 dimer interface [polypeptide binding]; other site 911045000862 active site 2 [active] 911045000863 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 911045000864 metal binding site 2 [ion binding]; metal-binding site 911045000865 putative DNA binding helix; other site 911045000866 metal binding site 1 [ion binding]; metal-binding site 911045000867 dimer interface [polypeptide binding]; other site 911045000868 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 911045000869 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 911045000870 minor groove reading motif; other site 911045000871 helix-hairpin-helix signature motif; other site 911045000872 substrate binding pocket [chemical binding]; other site 911045000873 active site 911045000874 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 911045000875 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 911045000876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045000877 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045000878 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 911045000879 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 911045000880 DNA binding site [nucleotide binding] 911045000881 active site 911045000882 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 911045000883 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 911045000884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045000885 catalytic residue [active] 911045000886 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 911045000887 active site 911045000888 Bacterial SH3 domain; Region: SH3_3; pfam08239 911045000889 chromosome segregation protein; Provisional; Region: PRK02224 911045000890 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 911045000891 Malic enzyme, N-terminal domain; Region: malic; pfam00390 911045000892 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 911045000893 putative NAD(P) binding site [chemical binding]; other site 911045000894 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 911045000895 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 911045000896 MutS domain I; Region: MutS_I; pfam01624 911045000897 MutS domain II; Region: MutS_II; pfam05188 911045000898 MutS domain III; Region: MutS_III; pfam05192 911045000899 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 911045000900 Walker A/P-loop; other site 911045000901 ATP binding site [chemical binding]; other site 911045000902 Q-loop/lid; other site 911045000903 ABC transporter signature motif; other site 911045000904 Walker B; other site 911045000905 D-loop; other site 911045000906 H-loop/switch region; other site 911045000907 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 911045000908 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 911045000909 putative active site [active] 911045000910 metal binding site [ion binding]; metal-binding site 911045000911 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 911045000912 trimer interface [polypeptide binding]; other site 911045000913 active site 911045000914 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 911045000915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045000916 motif II; other site 911045000917 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 911045000918 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 911045000919 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 911045000920 dimer interface [polypeptide binding]; other site 911045000921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045000922 catalytic residue [active] 911045000923 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 911045000924 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 911045000925 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 911045000926 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 911045000927 substrate binding site [chemical binding]; other site 911045000928 active site 911045000929 catalytic residues [active] 911045000930 heterodimer interface [polypeptide binding]; other site 911045000931 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 911045000932 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 911045000933 active site 911045000934 HIGH motif; other site 911045000935 dimer interface [polypeptide binding]; other site 911045000936 KMSKS motif; other site 911045000937 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045000938 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 911045000939 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 911045000940 PII uridylyl-transferase; Provisional; Region: PRK05092 911045000941 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 911045000942 metal binding triad; other site 911045000943 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 911045000944 HD domain; Region: HD; pfam01966 911045000945 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 911045000946 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 911045000947 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 911045000948 Smr domain; Region: Smr; pfam01713 911045000949 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 911045000950 MltA specific insert domain; Region: MltA; smart00925 911045000951 3D domain; Region: 3D; pfam06725 911045000952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 911045000953 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 911045000954 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 911045000955 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 911045000956 Predicted membrane protein [Function unknown]; Region: COG4763 911045000957 Acyltransferase family; Region: Acyl_transf_3; pfam01757 911045000958 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 911045000959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045000960 short chain dehydrogenase; Provisional; Region: PRK06179 911045000961 NAD(P) binding site [chemical binding]; other site 911045000962 active site 911045000963 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045000964 WHG domain; Region: WHG; pfam13305 911045000965 DNA polymerase I; Provisional; Region: PRK05755 911045000966 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 911045000967 active site 911045000968 metal binding site 1 [ion binding]; metal-binding site 911045000969 putative 5' ssDNA interaction site; other site 911045000970 metal binding site 3; metal-binding site 911045000971 metal binding site 2 [ion binding]; metal-binding site 911045000972 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 911045000973 putative DNA binding site [nucleotide binding]; other site 911045000974 putative metal binding site [ion binding]; other site 911045000975 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 911045000976 active site 911045000977 catalytic site [active] 911045000978 substrate binding site [chemical binding]; other site 911045000979 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 911045000980 active site 911045000981 DNA binding site [nucleotide binding] 911045000982 catalytic site [active] 911045000983 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 911045000984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 911045000985 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 911045000986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045000987 Coenzyme A binding pocket [chemical binding]; other site 911045000988 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 911045000989 active site 911045000990 Zn binding site [ion binding]; other site 911045000991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 911045000992 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 911045000993 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 911045000994 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 911045000995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045000996 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 911045000997 amphipathic channel; other site 911045000998 Asn-Pro-Ala signature motifs; other site 911045000999 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 911045001000 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045001001 N-terminal plug; other site 911045001002 ligand-binding site [chemical binding]; other site 911045001003 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 911045001004 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 911045001005 ATP binding site [chemical binding]; other site 911045001006 substrate interface [chemical binding]; other site 911045001007 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 911045001008 ribonuclease PH; Reviewed; Region: rph; PRK00173 911045001009 Ribonuclease PH; Region: RNase_PH_bact; cd11362 911045001010 hexamer interface [polypeptide binding]; other site 911045001011 active site 911045001012 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 911045001013 active site 911045001014 dimerization interface [polypeptide binding]; other site 911045001015 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 911045001016 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045001017 FeS/SAM binding site; other site 911045001018 HemN C-terminal domain; Region: HemN_C; pfam06969 911045001019 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 911045001020 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 911045001021 Uncharacterized conserved protein [Function unknown]; Region: COG3743 911045001022 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 911045001023 Protein of unknown function DUF45; Region: DUF45; pfam01863 911045001024 Transglycosylase; Region: Transgly; pfam00912 911045001025 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 911045001026 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 911045001027 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 911045001028 PAS domain S-box; Region: sensory_box; TIGR00229 911045001029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045001030 dimer interface [polypeptide binding]; other site 911045001031 phosphorylation site [posttranslational modification] 911045001032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001033 ATP binding site [chemical binding]; other site 911045001034 Mg2+ binding site [ion binding]; other site 911045001035 G-X-G motif; other site 911045001036 Response regulator receiver domain; Region: Response_reg; pfam00072 911045001037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045001038 active site 911045001039 phosphorylation site [posttranslational modification] 911045001040 intermolecular recognition site; other site 911045001041 dimerization interface [polypeptide binding]; other site 911045001042 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 911045001043 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 911045001044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045001045 Walker A motif; other site 911045001046 ATP binding site [chemical binding]; other site 911045001047 Walker B motif; other site 911045001048 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 911045001049 glutathione synthetase; Provisional; Region: PRK05246 911045001050 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 911045001051 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 911045001052 hypothetical protein; Reviewed; Region: PRK12497 911045001053 Predicted methyltransferases [General function prediction only]; Region: COG0313 911045001054 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 911045001055 putative SAM binding site [chemical binding]; other site 911045001056 putative homodimer interface [polypeptide binding]; other site 911045001057 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 911045001058 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 911045001059 putative ligand binding site [chemical binding]; other site 911045001060 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 911045001061 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 911045001062 Flavoprotein; Region: Flavoprotein; pfam02441 911045001063 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 911045001064 choline dehydrogenase; Validated; Region: PRK02106 911045001065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 911045001066 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 911045001067 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 911045001068 helicase 45; Provisional; Region: PTZ00424 911045001069 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 911045001070 ATP binding site [chemical binding]; other site 911045001071 Mg++ binding site [ion binding]; other site 911045001072 motif III; other site 911045001073 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045001074 nucleotide binding region [chemical binding]; other site 911045001075 ATP-binding site [chemical binding]; other site 911045001076 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045001077 putative DNA binding site [nucleotide binding]; other site 911045001078 putative Zn2+ binding site [ion binding]; other site 911045001079 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 911045001080 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 911045001081 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 911045001082 active site 911045001083 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 911045001084 LssY C-terminus; Region: LssY_C; pfam14067 911045001085 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 911045001086 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 911045001087 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 911045001088 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045001089 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 911045001090 active site 911045001091 catalytic tetrad [active] 911045001092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045001093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045001094 LysR substrate binding domain; Region: LysR_substrate; pfam03466 911045001095 dimerization interface [polypeptide binding]; other site 911045001096 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045001097 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045001098 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 911045001099 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045001100 FAD binding site [chemical binding]; other site 911045001101 substrate binding pocket [chemical binding]; other site 911045001102 catalytic base [active] 911045001103 aldehyde dehydrogenase family 7 member; Region: PLN02315 911045001104 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 911045001105 tetrameric interface [polypeptide binding]; other site 911045001106 NAD binding site [chemical binding]; other site 911045001107 catalytic residues [active] 911045001108 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045001109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045001110 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 911045001111 dimerization interface [polypeptide binding]; other site 911045001112 substrate binding pocket [chemical binding]; other site 911045001113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045001114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045001115 Coenzyme A binding pocket [chemical binding]; other site 911045001116 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 911045001117 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 911045001118 enoyl-CoA hydratase; Provisional; Region: PRK05862 911045001119 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045001120 substrate binding site [chemical binding]; other site 911045001121 oxyanion hole (OAH) forming residues; other site 911045001122 trimer interface [polypeptide binding]; other site 911045001123 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 911045001124 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 911045001125 active site residue [active] 911045001126 DnaA N-terminal domain; Region: DnaA_N; pfam11638 911045001127 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 911045001128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045001129 Walker A motif; other site 911045001130 ATP binding site [chemical binding]; other site 911045001131 Walker B motif; other site 911045001132 arginine finger; other site 911045001133 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 911045001134 DnaA box-binding interface [nucleotide binding]; other site 911045001135 DNA polymerase III subunit beta; Validated; Region: PRK05643 911045001136 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 911045001137 putative DNA binding surface [nucleotide binding]; other site 911045001138 dimer interface [polypeptide binding]; other site 911045001139 beta-clamp/clamp loader binding surface; other site 911045001140 beta-clamp/translesion DNA polymerase binding surface; other site 911045001141 recombination protein F; Reviewed; Region: recF; PRK00064 911045001142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045001143 Walker A/P-loop; other site 911045001144 ATP binding site [chemical binding]; other site 911045001145 Q-loop/lid; other site 911045001146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045001147 ABC transporter signature motif; other site 911045001148 Walker B; other site 911045001149 D-loop; other site 911045001150 H-loop/switch region; other site 911045001151 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045001152 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045001153 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045001154 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 911045001155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001156 Mg2+ binding site [ion binding]; other site 911045001157 G-X-G motif; other site 911045001158 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 911045001159 anchoring element; other site 911045001160 dimer interface [polypeptide binding]; other site 911045001161 ATP binding site [chemical binding]; other site 911045001162 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 911045001163 active site 911045001164 putative metal-binding site [ion binding]; other site 911045001165 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 911045001166 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045001167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045001168 DNA-binding site [nucleotide binding]; DNA binding site 911045001169 FCD domain; Region: FCD; pfam07729 911045001170 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 911045001171 CoenzymeA binding site [chemical binding]; other site 911045001172 subunit interaction site [polypeptide binding]; other site 911045001173 PHB binding site; other site 911045001174 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045001175 MarR family; Region: MarR; pfam01047 911045001176 MarR family; Region: MarR_2; cl17246 911045001177 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 911045001178 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 911045001179 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 911045001180 putative hemin binding site; other site 911045001181 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 911045001182 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045001183 ABC-ATPase subunit interface; other site 911045001184 dimer interface [polypeptide binding]; other site 911045001185 putative PBP binding regions; other site 911045001186 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 911045001187 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045001188 Walker A/P-loop; other site 911045001189 ATP binding site [chemical binding]; other site 911045001190 Q-loop/lid; other site 911045001191 ABC transporter signature motif; other site 911045001192 Walker B; other site 911045001193 D-loop; other site 911045001194 H-loop/switch region; other site 911045001195 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 911045001196 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045001197 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 911045001198 Walker A/P-loop; other site 911045001199 ATP binding site [chemical binding]; other site 911045001200 Q-loop/lid; other site 911045001201 ABC transporter signature motif; other site 911045001202 Walker B; other site 911045001203 D-loop; other site 911045001204 H-loop/switch region; other site 911045001205 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045001206 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045001207 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 911045001208 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 911045001209 NAD(P) binding site [chemical binding]; other site 911045001210 catalytic residues [active] 911045001211 choline dehydrogenase; Validated; Region: PRK02106 911045001212 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 911045001213 transcriptional regulator BetI; Validated; Region: PRK00767 911045001214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045001215 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 911045001216 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 911045001217 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 911045001218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001219 dimer interface [polypeptide binding]; other site 911045001220 conserved gate region; other site 911045001221 putative PBP binding loops; other site 911045001222 ABC-ATPase subunit interface; other site 911045001223 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 911045001224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045001225 Walker A/P-loop; other site 911045001226 ATP binding site [chemical binding]; other site 911045001227 Q-loop/lid; other site 911045001228 ABC transporter signature motif; other site 911045001229 Walker B; other site 911045001230 D-loop; other site 911045001231 H-loop/switch region; other site 911045001232 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 911045001233 Peptidase family M48; Region: Peptidase_M48; pfam01435 911045001234 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 911045001235 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 911045001236 putative active site [active] 911045001237 Zn binding site [ion binding]; other site 911045001238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045001239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045001240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045001241 dimerization interface [polypeptide binding]; other site 911045001242 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045001243 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 911045001244 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045001245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001246 dimer interface [polypeptide binding]; other site 911045001247 conserved gate region; other site 911045001248 putative PBP binding loops; other site 911045001249 ABC-ATPase subunit interface; other site 911045001250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 911045001251 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045001252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001253 dimer interface [polypeptide binding]; other site 911045001254 conserved gate region; other site 911045001255 putative PBP binding loops; other site 911045001256 ABC-ATPase subunit interface; other site 911045001257 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 911045001258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045001259 Walker A/P-loop; other site 911045001260 ATP binding site [chemical binding]; other site 911045001261 Q-loop/lid; other site 911045001262 ABC transporter signature motif; other site 911045001263 Walker B; other site 911045001264 D-loop; other site 911045001265 H-loop/switch region; other site 911045001266 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 911045001267 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 911045001268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045001269 Walker A/P-loop; other site 911045001270 ATP binding site [chemical binding]; other site 911045001271 Q-loop/lid; other site 911045001272 ABC transporter signature motif; other site 911045001273 Walker B; other site 911045001274 D-loop; other site 911045001275 H-loop/switch region; other site 911045001276 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 911045001277 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 911045001278 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 911045001279 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 911045001280 ligand binding site [chemical binding]; other site 911045001281 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 911045001282 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 911045001283 Walker A/P-loop; other site 911045001284 ATP binding site [chemical binding]; other site 911045001285 Q-loop/lid; other site 911045001286 ABC transporter signature motif; other site 911045001287 Walker B; other site 911045001288 D-loop; other site 911045001289 H-loop/switch region; other site 911045001290 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 911045001291 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045001292 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 911045001293 TM-ABC transporter signature motif; other site 911045001294 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 911045001295 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045001296 DNA binding residues [nucleotide binding] 911045001297 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 911045001298 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045001299 active site 911045001300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 911045001301 catalytic tetrad [active] 911045001302 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 911045001303 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 911045001304 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 911045001305 putative active site; other site 911045001306 catalytic residue [active] 911045001307 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 911045001308 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 911045001309 putative active site [active] 911045001310 putative N- and C-terminal domain interface [polypeptide binding]; other site 911045001311 putative xylulose binding site [chemical binding]; other site 911045001312 MgATP binding site [chemical binding]; other site 911045001313 choline dehydrogenase; Validated; Region: PRK02106 911045001314 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 911045001315 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 911045001316 Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434 911045001317 substrate binding site [chemical binding]; other site 911045001318 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 911045001319 substrate binding site [chemical binding]; other site 911045001320 ligand binding site [chemical binding]; other site 911045001321 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045001322 active site 911045001323 DNA binding site [nucleotide binding] 911045001324 Int/Topo IB signature motif; other site 911045001325 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 911045001326 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 911045001327 Walker A motif; other site 911045001328 ATP binding site [chemical binding]; other site 911045001329 Walker B motif; other site 911045001330 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 911045001331 active site 911045001332 catalytic residues [active] 911045001333 DNA binding site [nucleotide binding] 911045001334 Int/Topo IB signature motif; other site 911045001335 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 911045001336 Part of AAA domain; Region: AAA_19; pfam13245 911045001337 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 911045001338 AAA domain; Region: AAA_30; pfam13604 911045001339 AAA domain; Region: AAA_12; pfam13087 911045001340 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 911045001341 putative active site [active] 911045001342 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 911045001343 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 911045001344 metal binding triad [ion binding]; metal-binding site 911045001345 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 911045001346 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 911045001347 Zn2+ binding site [ion binding]; other site 911045001348 Mg2+ binding site [ion binding]; other site 911045001349 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 911045001350 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 911045001351 Imelysin; Region: Peptidase_M75; cl09159 911045001352 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 911045001353 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 911045001354 Imelysin; Region: Peptidase_M75; cl09159 911045001355 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 911045001356 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 911045001357 putative active site [active] 911045001358 catalytic site [active] 911045001359 putative metal binding site [ion binding]; other site 911045001360 Phage minor tail protein L; Region: Phage_tail_L; cl01908 911045001361 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045001362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001363 dimer interface [polypeptide binding]; other site 911045001364 conserved gate region; other site 911045001365 putative PBP binding loops; other site 911045001366 ABC-ATPase subunit interface; other site 911045001367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001368 dimer interface [polypeptide binding]; other site 911045001369 conserved gate region; other site 911045001370 putative PBP binding loops; other site 911045001371 ABC-ATPase subunit interface; other site 911045001372 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 911045001373 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045001374 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 911045001375 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045001376 Walker A/P-loop; other site 911045001377 ATP binding site [chemical binding]; other site 911045001378 Q-loop/lid; other site 911045001379 ABC transporter signature motif; other site 911045001380 Walker B; other site 911045001381 D-loop; other site 911045001382 H-loop/switch region; other site 911045001383 TOBE domain; Region: TOBE_2; pfam08402 911045001384 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 911045001385 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 911045001386 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 911045001387 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045001388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045001389 DNA-binding site [nucleotide binding]; DNA binding site 911045001390 FCD domain; Region: FCD; pfam07729 911045001391 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 911045001392 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 911045001393 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 911045001394 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 911045001395 NAD binding site [chemical binding]; other site 911045001396 dimer interface [polypeptide binding]; other site 911045001397 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 911045001398 substrate binding site [chemical binding]; other site 911045001399 tetramer (dimer of dimers) interface [polypeptide binding]; other site 911045001400 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 911045001401 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 911045001402 DNA binding site [nucleotide binding] 911045001403 catalytic residue [active] 911045001404 H2TH interface [polypeptide binding]; other site 911045001405 putative catalytic residues [active] 911045001406 turnover-facilitating residue; other site 911045001407 intercalation triad [nucleotide binding]; other site 911045001408 8OG recognition residue [nucleotide binding]; other site 911045001409 putative reading head residues; other site 911045001410 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 911045001411 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 911045001412 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 911045001413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045001414 S-adenosylmethionine binding site [chemical binding]; other site 911045001415 ABC1 family; Region: ABC1; cl17513 911045001416 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 911045001417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045001418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045001419 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 911045001420 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 911045001421 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 911045001422 active site 911045001423 FMN binding site [chemical binding]; other site 911045001424 substrate binding site [chemical binding]; other site 911045001425 3Fe-4S cluster binding site [ion binding]; other site 911045001426 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 911045001427 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 911045001428 NEF interaction site [polypeptide binding]; other site 911045001429 nucleotide binding site [chemical binding]; other site 911045001430 SBD interface [polypeptide binding]; other site 911045001431 chaperone protein DnaJ; Provisional; Region: PRK10767 911045001432 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 911045001433 HSP70 interaction site [polypeptide binding]; other site 911045001434 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 911045001435 substrate binding site [polypeptide binding]; other site 911045001436 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 911045001437 Zn binding sites [ion binding]; other site 911045001438 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 911045001439 dimer interface [polypeptide binding]; other site 911045001440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045001441 S-adenosylmethionine binding site [chemical binding]; other site 911045001442 Predicted flavoprotein [General function prediction only]; Region: COG0431 911045001443 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045001444 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 911045001445 active site 911045001446 HslU subunit interaction site [polypeptide binding]; other site 911045001447 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 911045001448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045001449 Walker A motif; other site 911045001450 ATP binding site [chemical binding]; other site 911045001451 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 911045001452 Walker B motif; other site 911045001453 arginine finger; other site 911045001454 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 911045001455 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 911045001456 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 911045001457 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 911045001458 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 911045001459 Glycoprotease family; Region: Peptidase_M22; pfam00814 911045001460 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045001461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045001462 Coenzyme A binding pocket [chemical binding]; other site 911045001463 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 911045001464 metal binding site 2 [ion binding]; metal-binding site 911045001465 putative DNA binding helix; other site 911045001466 metal binding site 1 [ion binding]; metal-binding site 911045001467 dimer interface [polypeptide binding]; other site 911045001468 structural Zn2+ binding site [ion binding]; other site 911045001469 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 911045001470 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 911045001471 putative acyl-acceptor binding pocket; other site 911045001472 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 911045001473 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 911045001474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045001475 FeS/SAM binding site; other site 911045001476 TRAM domain; Region: TRAM; cl01282 911045001477 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 911045001478 PhoH-like protein; Region: PhoH; pfam02562 911045001479 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 911045001480 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 911045001481 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 911045001482 Transporter associated domain; Region: CorC_HlyC; smart01091 911045001483 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 911045001484 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 911045001485 putative active site [active] 911045001486 catalytic triad [active] 911045001487 putative dimer interface [polypeptide binding]; other site 911045001488 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 911045001489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045001490 non-specific DNA binding site [nucleotide binding]; other site 911045001491 salt bridge; other site 911045001492 sequence-specific DNA binding site [nucleotide binding]; other site 911045001493 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 911045001494 S-adenosylmethionine synthetase; Validated; Region: PRK05250 911045001495 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 911045001496 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 911045001497 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 911045001498 ribosome maturation protein RimP; Reviewed; Region: PRK00092 911045001499 Sm and related proteins; Region: Sm_like; cl00259 911045001500 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 911045001501 putative oligomer interface [polypeptide binding]; other site 911045001502 putative RNA binding site [nucleotide binding]; other site 911045001503 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 911045001504 NusA N-terminal domain; Region: NusA_N; pfam08529 911045001505 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 911045001506 RNA binding site [nucleotide binding]; other site 911045001507 homodimer interface [polypeptide binding]; other site 911045001508 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 911045001509 G-X-X-G motif; other site 911045001510 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 911045001511 G-X-X-G motif; other site 911045001512 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 911045001513 Protein of unknown function (DUF448); Region: DUF448; pfam04296 911045001514 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 911045001515 translation initiation factor IF-2; Region: IF-2; TIGR00487 911045001516 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 911045001517 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 911045001518 G1 box; other site 911045001519 putative GEF interaction site [polypeptide binding]; other site 911045001520 GTP/Mg2+ binding site [chemical binding]; other site 911045001521 Switch I region; other site 911045001522 G2 box; other site 911045001523 G3 box; other site 911045001524 Switch II region; other site 911045001525 G4 box; other site 911045001526 G5 box; other site 911045001527 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 911045001528 Translation-initiation factor 2; Region: IF-2; pfam11987 911045001529 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 911045001530 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 911045001531 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 911045001532 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 911045001533 RNA binding site [nucleotide binding]; other site 911045001534 active site 911045001535 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 911045001536 16S/18S rRNA binding site [nucleotide binding]; other site 911045001537 S13e-L30e interaction site [polypeptide binding]; other site 911045001538 25S rRNA binding site [nucleotide binding]; other site 911045001539 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 911045001540 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 911045001541 RNase E interface [polypeptide binding]; other site 911045001542 trimer interface [polypeptide binding]; other site 911045001543 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 911045001544 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 911045001545 RNase E interface [polypeptide binding]; other site 911045001546 trimer interface [polypeptide binding]; other site 911045001547 active site 911045001548 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 911045001549 putative nucleic acid binding region [nucleotide binding]; other site 911045001550 G-X-X-G motif; other site 911045001551 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 911045001552 RNA binding site [nucleotide binding]; other site 911045001553 domain interface; other site 911045001554 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 911045001555 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045001556 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 911045001557 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 911045001558 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 911045001559 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045001560 catalytic core [active] 911045001561 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 911045001562 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045001563 catalytic core [active] 911045001564 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 911045001565 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045001566 substrate binding site [chemical binding]; other site 911045001567 ATP binding site [chemical binding]; other site 911045001568 prephenate dehydratase; Provisional; Region: PRK11899 911045001569 Prephenate dehydratase; Region: PDT; pfam00800 911045001570 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 911045001571 putative L-Phe binding site [chemical binding]; other site 911045001572 Cytochrome c2 [Energy production and conversion]; Region: COG3474 911045001573 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 911045001574 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 911045001575 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 911045001576 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 911045001577 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 911045001578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001579 dimer interface [polypeptide binding]; other site 911045001580 conserved gate region; other site 911045001581 putative PBP binding loops; other site 911045001582 ABC-ATPase subunit interface; other site 911045001583 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 911045001584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045001585 dimer interface [polypeptide binding]; other site 911045001586 conserved gate region; other site 911045001587 putative PBP binding loops; other site 911045001588 ABC-ATPase subunit interface; other site 911045001589 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 911045001590 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045001591 Walker A/P-loop; other site 911045001592 ATP binding site [chemical binding]; other site 911045001593 Q-loop/lid; other site 911045001594 ABC transporter signature motif; other site 911045001595 Walker B; other site 911045001596 D-loop; other site 911045001597 H-loop/switch region; other site 911045001598 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 911045001599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045001600 Walker A/P-loop; other site 911045001601 ATP binding site [chemical binding]; other site 911045001602 Q-loop/lid; other site 911045001603 ABC transporter signature motif; other site 911045001604 Walker B; other site 911045001605 D-loop; other site 911045001606 H-loop/switch region; other site 911045001607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045001608 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 911045001609 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045001610 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 911045001611 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 911045001612 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 911045001613 P loop; other site 911045001614 GTP binding site [chemical binding]; other site 911045001615 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 911045001616 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 911045001617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045001618 FeS/SAM binding site; other site 911045001619 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 911045001620 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 911045001621 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 911045001622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 911045001623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045001625 active site 911045001626 phosphorylation site [posttranslational modification] 911045001627 intermolecular recognition site; other site 911045001628 dimerization interface [polypeptide binding]; other site 911045001629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045001630 DNA binding site [nucleotide binding] 911045001631 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045001632 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045001633 ligand binding site [chemical binding]; other site 911045001634 flexible hinge region; other site 911045001635 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045001636 AsnC family; Region: AsnC_trans_reg; pfam01037 911045001637 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045001638 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045001639 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045001640 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 911045001641 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045001642 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 911045001643 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 911045001644 substrate binding site [chemical binding]; other site 911045001645 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 911045001646 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 911045001647 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 911045001648 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 911045001649 Uncharacterized conserved protein [Function unknown]; Region: COG4095 911045001650 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 911045001651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045001652 pantothenate kinase; Provisional; Region: PRK05439 911045001653 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 911045001654 ATP-binding site [chemical binding]; other site 911045001655 CoA-binding site [chemical binding]; other site 911045001656 Mg2+-binding site [ion binding]; other site 911045001657 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 911045001658 metal binding site [ion binding]; metal-binding site 911045001659 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 911045001660 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 911045001661 substrate binding site [chemical binding]; other site 911045001662 glutamase interaction surface [polypeptide binding]; other site 911045001663 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 911045001664 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 911045001665 catalytic residues [active] 911045001666 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 911045001667 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 911045001668 putative active site [active] 911045001669 oxyanion strand; other site 911045001670 catalytic triad [active] 911045001671 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 911045001672 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 911045001673 putative active site pocket [active] 911045001674 4-fold oligomerization interface [polypeptide binding]; other site 911045001675 metal binding residues [ion binding]; metal-binding site 911045001676 3-fold/trimer interface [polypeptide binding]; other site 911045001677 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 911045001678 active site 911045001679 dimer interface [polypeptide binding]; other site 911045001680 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 911045001681 putative substrate binding pocket [chemical binding]; other site 911045001682 AC domain interface; other site 911045001683 catalytic triad [active] 911045001684 AB domain interface; other site 911045001685 interchain disulfide; other site 911045001686 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 911045001687 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 911045001688 Nitrate and nitrite sensing; Region: NIT; pfam08376 911045001689 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 911045001690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045001691 dimerization interface [polypeptide binding]; other site 911045001692 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045001693 dimer interface [polypeptide binding]; other site 911045001694 putative CheW interface [polypeptide binding]; other site 911045001695 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 911045001696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045001697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045001698 active site 911045001699 phosphorylation site [posttranslational modification] 911045001700 intermolecular recognition site; other site 911045001701 dimerization interface [polypeptide binding]; other site 911045001702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045001703 DNA binding site [nucleotide binding] 911045001704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045001705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045001706 dimerization interface [polypeptide binding]; other site 911045001707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045001708 dimer interface [polypeptide binding]; other site 911045001709 phosphorylation site [posttranslational modification] 911045001710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001711 ATP binding site [chemical binding]; other site 911045001712 Mg2+ binding site [ion binding]; other site 911045001713 G-X-G motif; other site 911045001714 GTPase RsgA; Reviewed; Region: PRK01889 911045001715 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 911045001716 GTPase/Zn-binding domain interface [polypeptide binding]; other site 911045001717 GTP/Mg2+ binding site [chemical binding]; other site 911045001718 G4 box; other site 911045001719 G5 box; other site 911045001720 G1 box; other site 911045001721 Switch I region; other site 911045001722 G2 box; other site 911045001723 G3 box; other site 911045001724 Switch II region; other site 911045001725 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 911045001726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 911045001727 preprotein translocase subunit SecB; Validated; Region: PRK05751 911045001728 SecA binding site; other site 911045001729 Preprotein binding site; other site 911045001730 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045001731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045001732 dimer interface [polypeptide binding]; other site 911045001733 phosphorylation site [posttranslational modification] 911045001734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001735 ATP binding site [chemical binding]; other site 911045001736 Mg2+ binding site [ion binding]; other site 911045001737 G-X-G motif; other site 911045001738 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 911045001739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045001740 active site 911045001741 phosphorylation site [posttranslational modification] 911045001742 intermolecular recognition site; other site 911045001743 dimerization interface [polypeptide binding]; other site 911045001744 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 911045001745 intracellular septation protein A; Reviewed; Region: PRK00259 911045001746 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045001747 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045001748 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 911045001749 Methyltransferase domain; Region: Methyltransf_31; pfam13847 911045001750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045001751 S-adenosylmethionine binding site [chemical binding]; other site 911045001752 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 911045001753 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045001754 ABC-ATPase subunit interface; other site 911045001755 dimer interface [polypeptide binding]; other site 911045001756 putative PBP binding regions; other site 911045001757 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 911045001758 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 911045001759 putative ligand binding residues [chemical binding]; other site 911045001760 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 911045001761 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045001762 Walker A/P-loop; other site 911045001763 ATP binding site [chemical binding]; other site 911045001764 Q-loop/lid; other site 911045001765 ABC transporter signature motif; other site 911045001766 Walker B; other site 911045001767 D-loop; other site 911045001768 H-loop/switch region; other site 911045001769 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045001770 recombination protein RecR; Reviewed; Region: recR; PRK00076 911045001771 RecR protein; Region: RecR; pfam02132 911045001772 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 911045001773 putative active site [active] 911045001774 putative metal-binding site [ion binding]; other site 911045001775 tetramer interface [polypeptide binding]; other site 911045001776 hypothetical protein; Validated; Region: PRK00153 911045001777 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 911045001778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045001779 Walker A motif; other site 911045001780 ATP binding site [chemical binding]; other site 911045001781 Walker B motif; other site 911045001782 arginine finger; other site 911045001783 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 911045001784 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 911045001785 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 911045001786 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 911045001787 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 911045001788 putative NADH binding site [chemical binding]; other site 911045001789 putative active site [active] 911045001790 nudix motif; other site 911045001791 putative metal binding site [ion binding]; other site 911045001792 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045001793 catalytic core [active] 911045001794 CysZ-like protein; Reviewed; Region: PRK12768 911045001795 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 911045001796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045001797 Coenzyme A binding pocket [chemical binding]; other site 911045001798 RibD C-terminal domain; Region: RibD_C; cl17279 911045001799 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 911045001800 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 911045001801 proximal quinone binding site [chemical binding]; other site 911045001802 SdhD (CybS) interface [polypeptide binding]; other site 911045001803 proximal heme binding site [chemical binding]; other site 911045001804 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 911045001805 putative SdhC subunit interface [polypeptide binding]; other site 911045001806 putative proximal heme binding site [chemical binding]; other site 911045001807 putative Iron-sulfur protein interface [polypeptide binding]; other site 911045001808 putative proximal quinone binding site; other site 911045001809 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 911045001810 L-aspartate oxidase; Provisional; Region: PRK06175 911045001811 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 911045001812 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 911045001813 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 911045001814 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 911045001815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045001816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045001817 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 911045001818 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 911045001819 MAPEG family; Region: MAPEG; cl09190 911045001820 Protease inhibitor Inh; Region: Inh; pfam02974 911045001821 Predicted ATPase [General function prediction only]; Region: COG1485 911045001822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045001823 Walker A/P-loop; other site 911045001824 ATP binding site [chemical binding]; other site 911045001825 Q-loop/lid; other site 911045001826 ABC transporter signature motif; other site 911045001827 Walker B; other site 911045001828 D-loop; other site 911045001829 H-loop/switch region; other site 911045001830 malate dehydrogenase; Reviewed; Region: PRK06223 911045001831 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 911045001832 NAD(P) binding site [chemical binding]; other site 911045001833 dimer interface [polypeptide binding]; other site 911045001834 tetramer (dimer of dimers) interface [polypeptide binding]; other site 911045001835 substrate binding site [chemical binding]; other site 911045001836 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 911045001837 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 911045001838 CoA-ligase; Region: Ligase_CoA; pfam00549 911045001839 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 911045001840 CoA binding domain; Region: CoA_binding; smart00881 911045001841 CoA-ligase; Region: Ligase_CoA; pfam00549 911045001842 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 911045001843 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 911045001844 TPP-binding site [chemical binding]; other site 911045001845 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 911045001846 dimer interface [polypeptide binding]; other site 911045001847 PYR/PP interface [polypeptide binding]; other site 911045001848 TPP binding site [chemical binding]; other site 911045001849 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 911045001850 E3 interaction surface; other site 911045001851 lipoyl attachment site [posttranslational modification]; other site 911045001852 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 911045001853 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 911045001854 E3 interaction surface; other site 911045001855 lipoyl attachment site [posttranslational modification]; other site 911045001856 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 911045001857 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 911045001858 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 911045001859 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045001860 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 911045001861 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 911045001862 thiamine phosphate binding site [chemical binding]; other site 911045001863 active site 911045001864 pyrophosphate binding site [ion binding]; other site 911045001865 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 911045001866 substrate binding site [chemical binding]; other site 911045001867 multimerization interface [polypeptide binding]; other site 911045001868 ATP binding site [chemical binding]; other site 911045001869 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 911045001870 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045001871 active site 911045001872 DNA binding site [nucleotide binding] 911045001873 Int/Topo IB signature motif; other site 911045001874 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 911045001875 PLD-like domain; Region: PLDc_2; pfam13091 911045001876 putative active site [active] 911045001877 catalytic site [active] 911045001878 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 911045001879 PLD-like domain; Region: PLDc_2; pfam13091 911045001880 putative active site [active] 911045001881 catalytic site [active] 911045001882 Endonuclease I; Region: Endonuclease_1; pfam04231 911045001883 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 911045001884 Uncharacterized conserved protein [Function unknown]; Region: COG1683 911045001885 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 911045001886 active site 911045001887 intersubunit interactions; other site 911045001888 catalytic residue [active] 911045001889 primosome assembly protein PriA; Validated; Region: PRK05580 911045001890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045001891 ATP binding site [chemical binding]; other site 911045001892 putative Mg++ binding site [ion binding]; other site 911045001893 helicase superfamily c-terminal domain; Region: HELICc; smart00490 911045001894 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 911045001895 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 911045001896 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 911045001897 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 911045001898 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 911045001899 beta subunit interaction interface [polypeptide binding]; other site 911045001900 Walker A motif; other site 911045001901 ATP binding site [chemical binding]; other site 911045001902 Walker B motif; other site 911045001903 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 911045001904 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 911045001905 core domain interface [polypeptide binding]; other site 911045001906 delta subunit interface [polypeptide binding]; other site 911045001907 epsilon subunit interface [polypeptide binding]; other site 911045001908 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 911045001909 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 911045001910 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 911045001911 alpha subunit interaction interface [polypeptide binding]; other site 911045001912 Walker A motif; other site 911045001913 ATP binding site [chemical binding]; other site 911045001914 Walker B motif; other site 911045001915 inhibitor binding site; inhibition site 911045001916 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 911045001917 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 911045001918 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 911045001919 gamma subunit interface [polypeptide binding]; other site 911045001920 epsilon subunit interface [polypeptide binding]; other site 911045001921 LBP interface [polypeptide binding]; other site 911045001922 GcrA cell cycle regulator; Region: GcrA; cl11564 911045001923 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 911045001924 putative MPT binding site; other site 911045001925 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 911045001926 Ligand binding site; other site 911045001927 metal-binding site 911045001928 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 911045001929 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 911045001930 XdhC Rossmann domain; Region: XdhC_C; pfam13478 911045001931 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 911045001932 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 911045001933 active site 911045001934 substrate-binding site [chemical binding]; other site 911045001935 metal-binding site [ion binding] 911045001936 ATP binding site [chemical binding]; other site 911045001937 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045001938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045001939 active site 911045001940 phosphorylation site [posttranslational modification] 911045001941 intermolecular recognition site; other site 911045001942 dimerization interface [polypeptide binding]; other site 911045001943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045001944 DNA binding site [nucleotide binding] 911045001945 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 911045001946 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 911045001947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045001948 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045001949 dimerization interface [polypeptide binding]; other site 911045001950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045001951 dimer interface [polypeptide binding]; other site 911045001952 phosphorylation site [posttranslational modification] 911045001953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001954 ATP binding site [chemical binding]; other site 911045001955 Mg2+ binding site [ion binding]; other site 911045001956 G-X-G motif; other site 911045001957 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 911045001958 Hpr binding site; other site 911045001959 active site 911045001960 homohexamer subunit interaction site [polypeptide binding]; other site 911045001961 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 911045001962 active pocket/dimerization site; other site 911045001963 active site 911045001964 phosphorylation site [posttranslational modification] 911045001965 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 911045001966 dimerization domain swap beta strand [polypeptide binding]; other site 911045001967 regulatory protein interface [polypeptide binding]; other site 911045001968 active site 911045001969 regulatory phosphorylation site [posttranslational modification]; other site 911045001970 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045001971 nudix motif; other site 911045001972 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 911045001973 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 911045001974 homotetramer interface [polypeptide binding]; other site 911045001975 ligand binding site [chemical binding]; other site 911045001976 catalytic site [active] 911045001977 NAD binding site [chemical binding]; other site 911045001978 PAS fold; Region: PAS_7; pfam12860 911045001979 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 911045001980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045001981 dimer interface [polypeptide binding]; other site 911045001982 phosphorylation site [posttranslational modification] 911045001983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045001984 ATP binding site [chemical binding]; other site 911045001985 Mg2+ binding site [ion binding]; other site 911045001986 G-X-G motif; other site 911045001987 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 911045001988 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 911045001989 Phosphotransferase enzyme family; Region: APH; pfam01636 911045001990 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 911045001991 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 911045001992 Substrate binding site; other site 911045001993 metal-binding site 911045001994 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 911045001995 active site 911045001996 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 911045001997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045001998 Coenzyme A binding pocket [chemical binding]; other site 911045001999 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 911045002000 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 911045002001 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 911045002002 Family description; Region: UvrD_C_2; pfam13538 911045002003 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 911045002004 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 911045002005 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 911045002006 catalytic residues [active] 911045002007 heat shock protein GrpE; Provisional; Region: PRK14141 911045002008 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 911045002009 dimer interface [polypeptide binding]; other site 911045002010 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 911045002011 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 911045002012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045002013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045002014 Predicted membrane protein [Function unknown]; Region: COG2860 911045002015 UPF0126 domain; Region: UPF0126; pfam03458 911045002016 UPF0126 domain; Region: UPF0126; pfam03458 911045002017 ornithine cyclodeaminase; Validated; Region: PRK06141 911045002018 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 911045002019 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 911045002020 IHF dimer interface [polypeptide binding]; other site 911045002021 IHF - DNA interface [nucleotide binding]; other site 911045002022 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 911045002023 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 911045002024 tandem repeat interface [polypeptide binding]; other site 911045002025 oligomer interface [polypeptide binding]; other site 911045002026 active site residues [active] 911045002027 Chorismate mutase type II; Region: CM_2; cl00693 911045002028 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 911045002029 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 911045002030 putative NAD(P) binding site [chemical binding]; other site 911045002031 putative active site [active] 911045002032 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 911045002033 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 911045002034 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 911045002035 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 911045002036 RNA binding site [nucleotide binding]; other site 911045002037 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 911045002038 RNA binding site [nucleotide binding]; other site 911045002039 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 911045002040 RNA binding site [nucleotide binding]; other site 911045002041 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 911045002042 RNA binding site [nucleotide binding]; other site 911045002043 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 911045002044 RNA binding site [nucleotide binding]; other site 911045002045 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 911045002046 RNA binding site [nucleotide binding]; other site 911045002047 cytidylate kinase; Provisional; Region: cmk; PRK00023 911045002048 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 911045002049 CMP-binding site; other site 911045002050 The sites determining sugar specificity; other site 911045002051 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 911045002052 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 911045002053 hinge; other site 911045002054 active site 911045002055 TIGR02300 family protein; Region: FYDLN_acid 911045002056 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 911045002057 DNA photolyase; Region: DNA_photolyase; pfam00875 911045002058 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 911045002059 Fasciclin domain; Region: Fasciclin; pfam02469 911045002060 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 911045002061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045002062 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 911045002063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002064 dimer interface [polypeptide binding]; other site 911045002065 conserved gate region; other site 911045002066 putative PBP binding loops; other site 911045002067 ABC-ATPase subunit interface; other site 911045002068 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045002069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002070 dimer interface [polypeptide binding]; other site 911045002071 conserved gate region; other site 911045002072 putative PBP binding loops; other site 911045002073 ABC-ATPase subunit interface; other site 911045002074 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045002075 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045002076 Walker A/P-loop; other site 911045002077 ATP binding site [chemical binding]; other site 911045002078 Q-loop/lid; other site 911045002079 ABC transporter signature motif; other site 911045002080 Walker B; other site 911045002081 D-loop; other site 911045002082 H-loop/switch region; other site 911045002083 TOBE domain; Region: TOBE_2; pfam08402 911045002084 putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107 911045002085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045002086 FeS/SAM binding site; other site 911045002087 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 911045002088 MAPEG family; Region: MAPEG; pfam01124 911045002089 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 911045002090 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 911045002091 putative dimer interface [polypeptide binding]; other site 911045002092 Protein of unknown function (DUF1150); Region: DUF1150; cl11577 911045002093 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 911045002094 active site 911045002095 phosphorylation site [posttranslational modification] 911045002096 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 911045002097 30S subunit binding site; other site 911045002098 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 911045002099 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 911045002100 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 911045002101 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 911045002102 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 911045002103 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 911045002104 Walker A/P-loop; other site 911045002105 ATP binding site [chemical binding]; other site 911045002106 Q-loop/lid; other site 911045002107 ABC transporter signature motif; other site 911045002108 Walker B; other site 911045002109 D-loop; other site 911045002110 H-loop/switch region; other site 911045002111 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 911045002112 OstA-like protein; Region: OstA; pfam03968 911045002113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 911045002114 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 911045002115 catalytic site [active] 911045002116 putative active site [active] 911045002117 putative substrate binding site [chemical binding]; other site 911045002118 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 911045002119 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 911045002120 putative NAD(P) binding site [chemical binding]; other site 911045002121 active site 911045002122 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 911045002123 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045002124 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 911045002125 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 911045002126 N-terminal domain interface [polypeptide binding]; other site 911045002127 dimer interface [polypeptide binding]; other site 911045002128 substrate binding pocket (H-site) [chemical binding]; other site 911045002129 epoxyqueuosine reductase; Region: TIGR00276 911045002130 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 911045002131 HEAT repeat; Region: HEAT; pfam02985 911045002132 short chain dehydrogenase; Provisional; Region: PRK06197 911045002133 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 911045002134 putative NAD(P) binding site [chemical binding]; other site 911045002135 active site 911045002136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045002137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045002138 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 911045002139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045002140 non-specific DNA binding site [nucleotide binding]; other site 911045002141 salt bridge; other site 911045002142 sequence-specific DNA binding site [nucleotide binding]; other site 911045002143 2TM domain; Region: 2TM; pfam13239 911045002144 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 911045002145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045002146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045002147 homodimer interface [polypeptide binding]; other site 911045002148 catalytic residue [active] 911045002149 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045002150 MarR family; Region: MarR_2; pfam12802 911045002151 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 911045002152 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 911045002153 putative active site [active] 911045002154 Ap4A binding site [chemical binding]; other site 911045002155 nudix motif; other site 911045002156 putative metal binding site [ion binding]; other site 911045002157 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 911045002158 NodB motif; other site 911045002159 putative active site [active] 911045002160 putative catalytic site [active] 911045002161 Zn binding site [ion binding]; other site 911045002162 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 911045002163 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 911045002164 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 911045002165 protein binding site [polypeptide binding]; other site 911045002166 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 911045002167 Catalytic dyad [active] 911045002168 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 911045002169 Peptidase family M23; Region: Peptidase_M23; pfam01551 911045002170 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 911045002171 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 911045002172 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 911045002173 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 911045002174 active site 911045002175 (T/H)XGH motif; other site 911045002176 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 911045002177 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 911045002178 putative catalytic cysteine [active] 911045002179 gamma-glutamyl kinase; Provisional; Region: PRK05429 911045002180 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 911045002181 nucleotide binding site [chemical binding]; other site 911045002182 homotetrameric interface [polypeptide binding]; other site 911045002183 putative phosphate binding site [ion binding]; other site 911045002184 putative allosteric binding site; other site 911045002185 PUA domain; Region: PUA; pfam01472 911045002186 GTPase CgtA; Reviewed; Region: obgE; PRK12299 911045002187 GTP1/OBG; Region: GTP1_OBG; pfam01018 911045002188 Obg GTPase; Region: Obg; cd01898 911045002189 G1 box; other site 911045002190 GTP/Mg2+ binding site [chemical binding]; other site 911045002191 Switch I region; other site 911045002192 G2 box; other site 911045002193 G3 box; other site 911045002194 Switch II region; other site 911045002195 G4 box; other site 911045002196 G5 box; other site 911045002197 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002198 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045002199 Coenzyme A binding pocket [chemical binding]; other site 911045002200 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 911045002201 DNA-binding site [nucleotide binding]; DNA binding site 911045002202 RNA-binding motif; other site 911045002203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045002204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045002205 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 911045002206 OsmC-like protein; Region: OsmC; pfam02566 911045002207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002208 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045002209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002210 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045002211 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002212 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045002213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002214 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045002215 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002216 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045002217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045002219 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002220 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045002221 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 911045002222 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045002223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045002224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045002225 Coenzyme A binding pocket [chemical binding]; other site 911045002226 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 911045002227 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 911045002228 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 911045002229 Uncharacterized conserved protein [Function unknown]; Region: COG3743 911045002230 HAMP domain; Region: HAMP; pfam00672 911045002231 dimerization interface [polypeptide binding]; other site 911045002232 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 911045002233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045002234 dimer interface [polypeptide binding]; other site 911045002235 putative CheW interface [polypeptide binding]; other site 911045002236 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 911045002237 HsdM N-terminal domain; Region: HsdM_N; pfam12161 911045002238 Methyltransferase domain; Region: Methyltransf_26; pfam13659 911045002239 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 911045002240 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 911045002241 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 911045002242 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 911045002243 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 911045002244 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 911045002245 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045002246 ATP binding site [chemical binding]; other site 911045002247 putative Mg++ binding site [ion binding]; other site 911045002248 Protein of unknown function DUF45; Region: DUF45; pfam01863 911045002249 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045002251 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 911045002252 dimerization interface [polypeptide binding]; other site 911045002253 substrate binding pocket [chemical binding]; other site 911045002254 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 911045002255 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 911045002256 NAD binding site [chemical binding]; other site 911045002257 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 911045002258 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 911045002259 Nucleoside recognition; Region: Gate; pfam07670 911045002260 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 911045002261 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 911045002262 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 911045002263 active site 911045002264 metal binding site [ion binding]; metal-binding site 911045002265 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 911045002266 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 911045002267 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 911045002268 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 911045002269 DNA-binding interface [nucleotide binding]; DNA binding site 911045002270 Helix-turn-helix domain; Region: HTH_36; pfam13730 911045002271 integrase; Provisional; Region: PRK09692 911045002272 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 911045002273 active site 911045002274 Int/Topo IB signature motif; other site 911045002275 Methyltransferase domain; Region: Methyltransf_23; pfam13489 911045002276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045002277 S-adenosylmethionine binding site [chemical binding]; other site 911045002278 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045002279 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045002280 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 911045002281 xanthine permease; Region: pbuX; TIGR03173 911045002282 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 911045002283 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 911045002284 hypothetical protein; Provisional; Region: PRK11171 911045002285 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 911045002286 Cupin domain; Region: Cupin_2; pfam07883 911045002287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045002289 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045002290 putative effector binding pocket; other site 911045002291 dimerization interface [polypeptide binding]; other site 911045002292 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 911045002293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045002294 putative substrate translocation pore; other site 911045002295 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 911045002296 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 911045002297 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 911045002298 [4Fe-4S] binding site [ion binding]; other site 911045002299 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 911045002300 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 911045002301 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 911045002302 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 911045002303 molybdopterin cofactor binding site; other site 911045002304 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 911045002305 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 911045002306 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 911045002307 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 911045002308 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045002309 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045002310 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 911045002311 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 911045002312 putative ligand binding site [chemical binding]; other site 911045002313 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 911045002314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045002315 Walker A/P-loop; other site 911045002316 ATP binding site [chemical binding]; other site 911045002317 Q-loop/lid; other site 911045002318 ABC transporter signature motif; other site 911045002319 Walker B; other site 911045002320 D-loop; other site 911045002321 H-loop/switch region; other site 911045002322 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 911045002323 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045002324 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045002325 TM-ABC transporter signature motif; other site 911045002326 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045002327 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045002328 TM-ABC transporter signature motif; other site 911045002329 cytosine deaminase; Validated; Region: PRK07572 911045002330 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 911045002331 active site 911045002332 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 911045002333 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 911045002334 FMN binding site [chemical binding]; other site 911045002335 dimer interface [polypeptide binding]; other site 911045002336 Flagellar protein FliS; Region: FliS; cl00654 911045002337 NIPSNAP; Region: NIPSNAP; pfam07978 911045002338 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045002339 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045002340 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 911045002341 ornithine cyclodeaminase; Validated; Region: PRK07589 911045002342 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 911045002343 agmatinase; Region: agmatinase; TIGR01230 911045002344 Arginase family; Region: Arginase; cd09989 911045002345 active site 911045002346 Mn binding site [ion binding]; other site 911045002347 oligomer interface [polypeptide binding]; other site 911045002348 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045002349 AsnC family; Region: AsnC_trans_reg; pfam01037 911045002350 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 911045002351 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 911045002352 putative NAD(P) binding site [chemical binding]; other site 911045002353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045002355 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045002356 putative effector binding pocket; other site 911045002357 dimerization interface [polypeptide binding]; other site 911045002358 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 911045002359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045002360 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 911045002361 substrate binding pocket [chemical binding]; other site 911045002362 dimerization interface [polypeptide binding]; other site 911045002363 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 911045002364 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045002365 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045002366 ligand binding site [chemical binding]; other site 911045002367 flexible hinge region; other site 911045002368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045002369 S-adenosylmethionine binding site [chemical binding]; other site 911045002370 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 911045002371 Cupin; Region: Cupin_1; smart00835 911045002372 Cupin; Region: Cupin_1; smart00835 911045002373 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045002374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002375 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045002376 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 911045002377 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 911045002378 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 911045002379 cell division protein ZipA; Provisional; Region: PRK03427 911045002380 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 911045002381 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045002382 Cupin; Region: Cupin_6; pfam12852 911045002383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002384 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045002385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002386 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 911045002387 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 911045002388 MOFRL family; Region: MOFRL; pfam05161 911045002389 Proline racemase; Region: Pro_racemase; pfam05544 911045002390 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 911045002391 Predicted membrane protein [Function unknown]; Region: COG1238 911045002392 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 911045002393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045002394 DNA-binding site [nucleotide binding]; DNA binding site 911045002395 FCD domain; Region: FCD; pfam07729 911045002396 putative protease; Provisional; Region: PRK15447 911045002397 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 911045002398 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 911045002399 Peptidase family U32; Region: Peptidase_U32; pfam01136 911045002400 SCP-2 sterol transfer family; Region: SCP2; cl01225 911045002401 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 911045002402 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 911045002403 Flavoprotein; Region: Flavoprotein; pfam02441 911045002404 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 911045002405 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 911045002406 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 911045002407 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 911045002408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045002409 putative substrate translocation pore; other site 911045002410 guanine deaminase; Provisional; Region: PRK09228 911045002411 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 911045002412 active site 911045002413 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 911045002414 ACT domain; Region: ACT_6; pfam13740 911045002415 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 911045002416 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 911045002417 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 911045002418 putative active site [active] 911045002419 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 911045002420 putative active site [active] 911045002421 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 911045002422 Precorrin-8X methylmutase; Region: CbiC; pfam02570 911045002423 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 911045002424 active site 911045002425 putative homodimer interface [polypeptide binding]; other site 911045002426 SAM binding site [chemical binding]; other site 911045002427 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 911045002428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045002429 S-adenosylmethionine binding site [chemical binding]; other site 911045002430 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 911045002431 active site 911045002432 SAM binding site [chemical binding]; other site 911045002433 homodimer interface [polypeptide binding]; other site 911045002434 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 911045002435 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 911045002436 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 911045002437 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 911045002438 active site 911045002439 SAM binding site [chemical binding]; other site 911045002440 homodimer interface [polypeptide binding]; other site 911045002441 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 911045002442 active site 911045002443 SAM binding site [chemical binding]; other site 911045002444 homodimer interface [polypeptide binding]; other site 911045002445 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 911045002446 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 911045002447 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 911045002448 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 911045002449 active site 911045002450 SAM binding site [chemical binding]; other site 911045002451 homodimer interface [polypeptide binding]; other site 911045002452 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 911045002453 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 911045002454 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 911045002455 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 911045002456 RibD C-terminal domain; Region: RibD_C; pfam01872 911045002457 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 911045002458 dimer interface [polypeptide binding]; other site 911045002459 ADP-ribose binding site [chemical binding]; other site 911045002460 active site 911045002461 nudix motif; other site 911045002462 metal binding site [ion binding]; metal-binding site 911045002463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 911045002464 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045002465 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045002466 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 911045002467 active site 911045002468 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 911045002469 putative NAD(P) binding site [chemical binding]; other site 911045002470 glucosyltransferase MdoH; Provisional; Region: PRK05454 911045002471 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 911045002472 active site 911045002473 OpgC protein; Region: OpgC_C; pfam10129 911045002474 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 911045002475 Sulphur transport; Region: Sulf_transp; pfam04143 911045002476 Domain of unknown function DUF302; Region: DUF302; pfam03625 911045002477 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 911045002478 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045002479 PYR/PP interface [polypeptide binding]; other site 911045002480 dimer interface [polypeptide binding]; other site 911045002481 TPP binding site [chemical binding]; other site 911045002482 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 911045002483 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 911045002484 TPP-binding site [chemical binding]; other site 911045002485 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045002486 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045002487 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 911045002488 short chain dehydrogenase; Provisional; Region: PRK05854 911045002489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002490 NAD(P) binding site [chemical binding]; other site 911045002491 active site 911045002492 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045002493 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045002494 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045002495 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045002496 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045002497 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045002498 ligand binding site [chemical binding]; other site 911045002499 CAAX protease self-immunity; Region: Abi; pfam02517 911045002500 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045002501 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 911045002502 Walker A/P-loop; other site 911045002503 ATP binding site [chemical binding]; other site 911045002504 Q-loop/lid; other site 911045002505 ABC transporter signature motif; other site 911045002506 Walker B; other site 911045002507 D-loop; other site 911045002508 H-loop/switch region; other site 911045002509 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045002510 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 911045002511 Walker A/P-loop; other site 911045002512 ATP binding site [chemical binding]; other site 911045002513 Q-loop/lid; other site 911045002514 ABC transporter signature motif; other site 911045002515 Walker B; other site 911045002516 D-loop; other site 911045002517 H-loop/switch region; other site 911045002518 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 911045002519 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045002520 TM-ABC transporter signature motif; other site 911045002521 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045002522 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045002523 TM-ABC transporter signature motif; other site 911045002524 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045002525 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 911045002526 putative ligand binding site [chemical binding]; other site 911045002527 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 911045002528 heme-binding site [chemical binding]; other site 911045002529 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045002530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045002531 dimer interface [polypeptide binding]; other site 911045002532 putative CheW interface [polypeptide binding]; other site 911045002533 Predicted transcriptional regulator [Transcription]; Region: COG1959 911045002534 Transcriptional regulator; Region: Rrf2; cl17282 911045002535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045002536 dimerization interface [polypeptide binding]; other site 911045002537 PAS fold; Region: PAS_7; pfam12860 911045002538 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 911045002539 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045002540 metal binding site [ion binding]; metal-binding site 911045002541 active site 911045002542 I-site; other site 911045002543 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045002544 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045002545 catalytic loop [active] 911045002546 iron binding site [ion binding]; other site 911045002547 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 911045002548 FAD binding pocket [chemical binding]; other site 911045002549 conserved FAD binding motif [chemical binding]; other site 911045002550 phosphate binding motif [ion binding]; other site 911045002551 beta-alpha-beta structure motif; other site 911045002552 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 911045002553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045002554 binding surface 911045002555 TPR motif; other site 911045002556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045002557 S-adenosylmethionine binding site [chemical binding]; other site 911045002558 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 911045002559 intracellular protease, PfpI family; Region: PfpI; TIGR01382 911045002560 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 911045002561 conserved cys residue [active] 911045002562 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 911045002563 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 911045002564 active site 911045002565 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045002566 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 911045002567 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 911045002568 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045002569 homotrimer interaction site [polypeptide binding]; other site 911045002570 putative active site [active] 911045002571 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045002572 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 911045002573 conserved cys residue [active] 911045002574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002575 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 911045002576 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 911045002577 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045002578 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 911045002579 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045002580 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045002581 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045002582 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045002583 active site 911045002584 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 911045002585 active site 911045002586 substrate binding pocket [chemical binding]; other site 911045002587 dimer interface [polypeptide binding]; other site 911045002588 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 911045002589 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 911045002590 Creatinine amidohydrolase; Region: Creatininase; pfam02633 911045002591 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 911045002592 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045002593 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 911045002594 Amidinotransferase; Region: Amidinotransf; pfam02274 911045002595 Cupin domain; Region: Cupin_2; cl17218 911045002596 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045002597 NnrS protein; Region: NnrS; pfam05940 911045002598 GSCFA family; Region: GSCFA; pfam08885 911045002599 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 911045002600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045002601 binding surface 911045002602 TPR motif; other site 911045002603 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 911045002604 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 911045002605 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 911045002606 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 911045002607 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 911045002608 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 911045002609 Ethylbenzene dehydrogenase; Region: EB_dh; pfam09459 911045002610 putative ligand binding site [chemical binding]; other site 911045002611 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 911045002612 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 911045002613 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 911045002614 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 911045002615 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 911045002616 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 911045002617 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045002618 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045002619 Walker A/P-loop; other site 911045002620 ATP binding site [chemical binding]; other site 911045002621 Q-loop/lid; other site 911045002622 ABC transporter signature motif; other site 911045002623 Walker B; other site 911045002624 D-loop; other site 911045002625 H-loop/switch region; other site 911045002626 TOBE domain; Region: TOBE_2; pfam08402 911045002627 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045002628 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 911045002629 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045002630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002631 dimer interface [polypeptide binding]; other site 911045002632 conserved gate region; other site 911045002633 putative PBP binding loops; other site 911045002634 ABC-ATPase subunit interface; other site 911045002635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045002636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002637 dimer interface [polypeptide binding]; other site 911045002638 conserved gate region; other site 911045002639 putative PBP binding loops; other site 911045002640 ABC-ATPase subunit interface; other site 911045002641 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 911045002642 Trehalase; Region: Trehalase; cl17346 911045002643 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045002644 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045002645 DNA binding site [nucleotide binding] 911045002646 domain linker motif; other site 911045002647 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045002648 ligand binding site [chemical binding]; other site 911045002649 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 911045002650 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 911045002651 ATP binding site [chemical binding]; other site 911045002652 substrate interface [chemical binding]; other site 911045002653 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 911045002654 active site residue [active] 911045002655 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 911045002656 thiamine phosphate binding site [chemical binding]; other site 911045002657 active site 911045002658 pyrophosphate binding site [ion binding]; other site 911045002659 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 911045002660 ThiS interaction site; other site 911045002661 putative active site [active] 911045002662 tetramer interface [polypeptide binding]; other site 911045002663 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 911045002664 thiS-thiF/thiG interaction site; other site 911045002665 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 911045002666 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 911045002667 ThiC-associated domain; Region: ThiC-associated; pfam13667 911045002668 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 911045002669 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 911045002670 metal binding site [ion binding]; metal-binding site 911045002671 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 911045002672 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 911045002673 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 911045002674 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 911045002675 putative active site [active] 911045002676 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045002677 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045002678 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045002679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002680 dimer interface [polypeptide binding]; other site 911045002681 conserved gate region; other site 911045002682 putative PBP binding loops; other site 911045002683 ABC-ATPase subunit interface; other site 911045002684 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045002685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002686 dimer interface [polypeptide binding]; other site 911045002687 conserved gate region; other site 911045002688 putative PBP binding loops; other site 911045002689 ABC-ATPase subunit interface; other site 911045002690 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045002691 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045002692 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045002693 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045002694 Walker A/P-loop; other site 911045002695 ATP binding site [chemical binding]; other site 911045002696 Q-loop/lid; other site 911045002697 ABC transporter signature motif; other site 911045002698 Walker B; other site 911045002699 D-loop; other site 911045002700 H-loop/switch region; other site 911045002701 TOBE domain; Region: TOBE_2; pfam08402 911045002702 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 911045002703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045002704 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045002705 dimerization interface [polypeptide binding]; other site 911045002706 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 911045002707 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 911045002708 Nucleoside recognition; Region: Gate; pfam07670 911045002709 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 911045002710 Uncharacterized conserved protein [Function unknown]; Region: COG3791 911045002711 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045002712 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 911045002713 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045002714 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045002715 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045002716 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045002717 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045002718 urocanate hydratase; Provisional; Region: PRK05414 911045002719 N-formylglutamate amidohydrolase; Region: FGase; cl01522 911045002720 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 911045002721 active sites [active] 911045002722 tetramer interface [polypeptide binding]; other site 911045002723 imidazolonepropionase; Validated; Region: PRK09356 911045002724 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 911045002725 active site 911045002726 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 911045002727 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 911045002728 active site 911045002729 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 911045002730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045002731 DNA-binding site [nucleotide binding]; DNA binding site 911045002732 UTRA domain; Region: UTRA; pfam07702 911045002733 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 911045002734 NADH(P)-binding; Region: NAD_binding_10; pfam13460 911045002735 NAD(P) binding site [chemical binding]; other site 911045002736 putative active site [active] 911045002737 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 911045002738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045002739 putative PBP binding loops; other site 911045002740 ABC-ATPase subunit interface; other site 911045002741 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 911045002742 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 911045002743 Walker A/P-loop; other site 911045002744 ATP binding site [chemical binding]; other site 911045002745 Q-loop/lid; other site 911045002746 ABC transporter signature motif; other site 911045002747 Walker B; other site 911045002748 D-loop; other site 911045002749 H-loop/switch region; other site 911045002750 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 911045002751 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 911045002752 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 911045002753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045002754 DNA-binding site [nucleotide binding]; DNA binding site 911045002755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045002756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045002757 homodimer interface [polypeptide binding]; other site 911045002758 catalytic residue [active] 911045002759 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 911045002760 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045002761 inhibitor-cofactor binding pocket; inhibition site 911045002762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045002763 catalytic residue [active] 911045002764 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045002765 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045002766 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 911045002767 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 911045002768 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045002769 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 911045002770 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045002771 PYR/PP interface [polypeptide binding]; other site 911045002772 dimer interface [polypeptide binding]; other site 911045002773 TPP binding site [chemical binding]; other site 911045002774 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 911045002775 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 911045002776 TPP-binding site [chemical binding]; other site 911045002777 aminodeoxychorismate synthase; Provisional; Region: PRK07508 911045002778 chorismate binding enzyme; Region: Chorismate_bind; cl10555 911045002779 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 911045002780 hypothetical protein; Provisional; Region: PRK07546 911045002781 substrate-cofactor binding pocket; other site 911045002782 homodimer interface [polypeptide binding]; other site 911045002783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045002784 catalytic residue [active] 911045002785 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045002786 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045002787 dimer interface [polypeptide binding]; other site 911045002788 putative CheW interface [polypeptide binding]; other site 911045002789 MarR family; Region: MarR_2; pfam12802 911045002790 methionine sulfoxide reductase A; Provisional; Region: PRK00058 911045002791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045002793 LysR substrate binding domain; Region: LysR_substrate; pfam03466 911045002794 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045002795 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 911045002796 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 911045002797 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 911045002798 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045002799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002800 NAD(P) binding site [chemical binding]; other site 911045002801 active site 911045002802 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 911045002803 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 911045002804 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 911045002805 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 911045002806 dimer interface [polypeptide binding]; other site 911045002807 motif 1; other site 911045002808 active site 911045002809 motif 2; other site 911045002810 motif 3; other site 911045002811 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 911045002812 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 911045002813 putative tRNA-binding site [nucleotide binding]; other site 911045002814 B3/4 domain; Region: B3_4; pfam03483 911045002815 tRNA synthetase B5 domain; Region: B5; smart00874 911045002816 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 911045002817 dimer interface [polypeptide binding]; other site 911045002818 motif 1; other site 911045002819 motif 3; other site 911045002820 motif 2; other site 911045002821 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 911045002822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 911045002823 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 911045002824 tyrosine phenol-lyase; Provisional; Region: PRK13237 911045002825 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 911045002826 substrate binding site [chemical binding]; other site 911045002827 tetramer interface [polypeptide binding]; other site 911045002828 catalytic residue [active] 911045002829 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 911045002830 aromatic amino acid transport protein; Region: araaP; TIGR00837 911045002831 TfuA-like protein; Region: TfuA; pfam07812 911045002832 Uncharacterized conserved protein [Function unknown]; Region: COG1944 911045002833 YcaO-like family; Region: YcaO; pfam02624 911045002834 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045002835 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045002836 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 911045002837 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 911045002838 TrkA-N domain; Region: TrkA_N; pfam02254 911045002839 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 911045002840 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 911045002841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002842 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045002843 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 911045002844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045002845 protochlorophyllide reductase; Region: PLN00015 911045002846 NAD(P) binding site [chemical binding]; other site 911045002847 active site 911045002848 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002849 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045002850 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045002851 dimerization interface [polypeptide binding]; other site 911045002852 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 911045002853 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 911045002854 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 911045002855 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 911045002856 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 911045002857 PhnA protein; Region: PhnA; pfam03831 911045002858 GTP-binding protein LepA; Provisional; Region: PRK05433 911045002859 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 911045002860 G1 box; other site 911045002861 putative GEF interaction site [polypeptide binding]; other site 911045002862 GTP/Mg2+ binding site [chemical binding]; other site 911045002863 Switch I region; other site 911045002864 G2 box; other site 911045002865 G3 box; other site 911045002866 Switch II region; other site 911045002867 G4 box; other site 911045002868 G5 box; other site 911045002869 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 911045002870 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 911045002871 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 911045002872 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 911045002873 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 911045002874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045002875 Coenzyme A binding pocket [chemical binding]; other site 911045002876 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 911045002877 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 911045002878 active site 911045002879 nucleophile elbow; other site 911045002880 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 911045002881 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045002882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045002884 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 911045002885 substrate binding pocket [chemical binding]; other site 911045002886 dimerization interface [polypeptide binding]; other site 911045002887 short chain dehydrogenase; Provisional; Region: PRK08267 911045002888 classical (c) SDRs; Region: SDR_c; cd05233 911045002889 NAD(P) binding site [chemical binding]; other site 911045002890 active site 911045002891 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 911045002892 active site 911045002893 multimer interface [polypeptide binding]; other site 911045002894 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 911045002895 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045002896 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 911045002897 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045002898 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045002899 active site 911045002900 metal binding site [ion binding]; metal-binding site 911045002901 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045002902 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045002903 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045002904 dimerization interface [polypeptide binding]; other site 911045002905 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045002906 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045002907 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 911045002908 putative ADP-binding pocket [chemical binding]; other site 911045002909 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 911045002910 translation initiation factor IF-3; Region: infC; TIGR00168 911045002911 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 911045002912 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 911045002913 nucleoside/Zn binding site; other site 911045002914 dimer interface [polypeptide binding]; other site 911045002915 catalytic motif [active] 911045002916 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 911045002917 nucleoside/Zn binding site; other site 911045002918 dimer interface [polypeptide binding]; other site 911045002919 catalytic motif [active] 911045002920 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 911045002921 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 911045002922 23S rRNA binding site [nucleotide binding]; other site 911045002923 L21 binding site [polypeptide binding]; other site 911045002924 L13 binding site [polypeptide binding]; other site 911045002925 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 911045002926 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045002927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045002928 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 911045002929 substrate binding site [chemical binding]; other site 911045002930 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 911045002931 putative acetyltransferase; Provisional; Region: PRK03624 911045002932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045002933 Coenzyme A binding pocket [chemical binding]; other site 911045002934 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045002935 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045002936 dimer interface [polypeptide binding]; other site 911045002937 putative CheW interface [polypeptide binding]; other site 911045002938 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 911045002939 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 911045002940 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 911045002941 Uncharacterized conserved protein [Function unknown]; Region: COG3791 911045002942 Uncharacterized conserved protein [Function unknown]; Region: COG3791 911045002943 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045002944 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 911045002945 putative NAD(P) binding site [chemical binding]; other site 911045002946 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 911045002947 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 911045002948 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 911045002949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045002950 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 911045002951 putative hydrophobic ligand binding site [chemical binding]; other site 911045002952 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 911045002953 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 911045002954 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 911045002955 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 911045002956 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 911045002957 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045002958 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 911045002959 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 911045002960 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 911045002961 classical (c) SDRs; Region: SDR_c; cd05233 911045002962 NAD(P) binding site [chemical binding]; other site 911045002963 active site 911045002964 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 911045002965 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 911045002966 heme binding site [chemical binding]; other site 911045002967 ferroxidase pore; other site 911045002968 ferroxidase diiron center [ion binding]; other site 911045002969 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 911045002970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045002971 ATP binding site [chemical binding]; other site 911045002972 putative Mg++ binding site [ion binding]; other site 911045002973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045002974 nucleotide binding region [chemical binding]; other site 911045002975 ATP-binding site [chemical binding]; other site 911045002976 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 911045002977 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 911045002978 glucokinase; Provisional; Region: glk; PRK00292 911045002979 glucokinase, proteobacterial type; Region: glk; TIGR00749 911045002980 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 911045002981 active site 911045002982 dimer interfaces [polypeptide binding]; other site 911045002983 catalytic residues [active] 911045002984 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 911045002985 metal ion-dependent adhesion site (MIDAS); other site 911045002986 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 911045002987 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 911045002988 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 911045002989 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 911045002990 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 911045002991 ligand binding site [chemical binding]; other site 911045002992 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 911045002993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045002994 Walker A/P-loop; other site 911045002995 ATP binding site [chemical binding]; other site 911045002996 Q-loop/lid; other site 911045002997 ABC transporter signature motif; other site 911045002998 Walker B; other site 911045002999 D-loop; other site 911045003000 H-loop/switch region; other site 911045003001 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 911045003002 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045003003 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045003004 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045003005 TM-ABC transporter signature motif; other site 911045003006 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045003007 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045003008 TM-ABC transporter signature motif; other site 911045003009 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 911045003010 active site 911045003011 catalytic motif [active] 911045003012 Zn binding site [ion binding]; other site 911045003013 purine nucleoside phosphorylase; Provisional; Region: PRK08202 911045003014 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 911045003015 intersubunit interface [polypeptide binding]; other site 911045003016 active site 911045003017 catalytic residue [active] 911045003018 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 911045003019 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 911045003020 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 911045003021 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 911045003022 phosphopentomutase; Provisional; Region: PRK05362 911045003023 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 911045003024 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 911045003025 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 911045003026 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 911045003027 active site 911045003028 purine riboside binding site [chemical binding]; other site 911045003029 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 911045003030 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045003031 active site 911045003032 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 911045003033 active site 911045003034 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 911045003035 catalytic motif [active] 911045003036 Catalytic residue [active] 911045003037 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 911045003038 active site 911045003039 catalytic residues [active] 911045003040 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 911045003041 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 911045003042 active site 911045003043 Zn binding site [ion binding]; other site 911045003044 Protein of unknown function (DUF805); Region: DUF805; pfam05656 911045003045 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 911045003046 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 911045003047 metal binding site [ion binding]; metal-binding site 911045003048 dimer interface [polypeptide binding]; other site 911045003049 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 911045003050 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 911045003051 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 911045003052 dimerization interface 3.5A [polypeptide binding]; other site 911045003053 active site 911045003054 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045003055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045003056 Coenzyme A binding pocket [chemical binding]; other site 911045003057 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 911045003058 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 911045003059 putative active site [active] 911045003060 substrate binding site [chemical binding]; other site 911045003061 putative cosubstrate binding site; other site 911045003062 catalytic site [active] 911045003063 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 911045003064 substrate binding site [chemical binding]; other site 911045003065 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 911045003066 active site 911045003067 catalytic residues [active] 911045003068 metal binding site [ion binding]; metal-binding site 911045003069 RmuC family; Region: RmuC; pfam02646 911045003070 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045003071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045003072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045003073 dimerization interface [polypeptide binding]; other site 911045003074 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 911045003075 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045003076 putative metal binding site [ion binding]; other site 911045003077 Predicted amidohydrolase [General function prediction only]; Region: COG0388 911045003078 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 911045003079 putative active site [active] 911045003080 catalytic triad [active] 911045003081 putative dimer interface [polypeptide binding]; other site 911045003082 Predicted amidohydrolase [General function prediction only]; Region: COG0388 911045003083 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 911045003084 putative active site [active] 911045003085 catalytic triad [active] 911045003086 putative dimer interface [polypeptide binding]; other site 911045003087 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 911045003088 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 911045003089 putative ligand binding site [chemical binding]; other site 911045003090 NAD binding site [chemical binding]; other site 911045003091 dimerization interface [polypeptide binding]; other site 911045003092 catalytic site [active] 911045003093 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 911045003094 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 911045003095 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 911045003096 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 911045003097 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 911045003098 BON domain; Region: BON; pfam04972 911045003099 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 911045003100 Type IV pili component [Cell motility and secretion]; Region: COG5461 911045003101 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 911045003102 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 911045003103 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 911045003104 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 911045003105 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 911045003106 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 911045003107 ATP binding site [chemical binding]; other site 911045003108 Walker A motif; other site 911045003109 hexamer interface [polypeptide binding]; other site 911045003110 Walker B motif; other site 911045003111 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 911045003112 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 911045003113 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 911045003114 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 911045003115 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 911045003116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045003117 TPR motif; other site 911045003118 binding surface 911045003119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045003120 TPR motif; other site 911045003121 binding surface 911045003122 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 911045003123 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 911045003124 interface (dimer of trimers) [polypeptide binding]; other site 911045003125 Substrate-binding/catalytic site; other site 911045003126 Zn-binding sites [ion binding]; other site 911045003127 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 911045003128 NlpC/P60 family; Region: NLPC_P60; cl17555 911045003129 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 911045003130 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 911045003131 TadE-like protein; Region: TadE; pfam07811 911045003132 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 911045003133 TadE-like protein; Region: TadE; pfam07811 911045003134 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 911045003135 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 911045003136 dimer interaction site [polypeptide binding]; other site 911045003137 substrate-binding tunnel; other site 911045003138 active site 911045003139 catalytic site [active] 911045003140 substrate binding site [chemical binding]; other site 911045003141 phosphate acetyltransferase; Provisional; Region: PRK11890 911045003142 propionate/acetate kinase; Provisional; Region: PRK12379 911045003143 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 911045003144 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 911045003145 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 911045003146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045003147 motif II; other site 911045003148 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 911045003149 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 911045003150 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 911045003151 trimer interface [polypeptide binding]; other site 911045003152 active site 911045003153 substrate binding site [chemical binding]; other site 911045003154 CoA binding site [chemical binding]; other site 911045003155 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045003156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045003157 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045003158 dimerization interface [polypeptide binding]; other site 911045003159 substrate binding pocket [chemical binding]; other site 911045003160 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 911045003161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 911045003162 motif II; other site 911045003163 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 911045003164 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 911045003165 homohexameric interface [polypeptide binding]; other site 911045003166 nucleotide binding site [chemical binding]; other site 911045003167 N-acetyl-L-glutamate binding site [chemical binding]; other site 911045003168 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045003169 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 911045003170 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 911045003171 G1 box; other site 911045003172 GTP/Mg2+ binding site [chemical binding]; other site 911045003173 Switch I region; other site 911045003174 G2 box; other site 911045003175 G3 box; other site 911045003176 Switch II region; other site 911045003177 G4 box; other site 911045003178 G5 box; other site 911045003179 membrane protein insertase; Provisional; Region: PRK01318 911045003180 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 911045003181 Ribonuclease P; Region: Ribonuclease_P; cl00457 911045003182 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 911045003183 Uncharacterized conserved protein [Function unknown]; Region: COG0398 911045003184 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 911045003185 mercuric reductase; Validated; Region: PRK06370 911045003186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045003187 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 911045003188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045003189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045003190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 911045003191 dimer interface [polypeptide binding]; other site 911045003192 phosphorylation site [posttranslational modification] 911045003193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045003194 ATP binding site [chemical binding]; other site 911045003195 Mg2+ binding site [ion binding]; other site 911045003196 G-X-G motif; other site 911045003197 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 911045003198 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 911045003199 active site 911045003200 dimer interface [polypeptide binding]; other site 911045003201 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 911045003202 putative FMN binding site [chemical binding]; other site 911045003203 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 911045003204 MPT binding site; other site 911045003205 trimer interface [polypeptide binding]; other site 911045003206 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 911045003207 iron-sulfur cluster [ion binding]; other site 911045003208 [2Fe-2S] cluster binding site [ion binding]; other site 911045003209 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 911045003210 active site 911045003211 FMN binding site [chemical binding]; other site 911045003212 substrate binding site [chemical binding]; other site 911045003213 3Fe-4S cluster binding site [ion binding]; other site 911045003214 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 911045003215 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 911045003216 iron-sulfur cluster [ion binding]; other site 911045003217 [2Fe-2S] cluster binding site [ion binding]; other site 911045003218 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045003219 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 911045003220 C-terminal domain interface [polypeptide binding]; other site 911045003221 GSH binding site (G-site) [chemical binding]; other site 911045003222 dimer interface [polypeptide binding]; other site 911045003223 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 911045003224 N-terminal domain interface [polypeptide binding]; other site 911045003225 dimer interface [polypeptide binding]; other site 911045003226 substrate binding pocket (H-site) [chemical binding]; other site 911045003227 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045003228 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045003229 substrate binding pocket [chemical binding]; other site 911045003230 membrane-bound complex binding site; other site 911045003231 hinge residues; other site 911045003232 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045003233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003234 dimer interface [polypeptide binding]; other site 911045003235 conserved gate region; other site 911045003236 putative PBP binding loops; other site 911045003237 ABC-ATPase subunit interface; other site 911045003238 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 911045003239 nudix motif; other site 911045003240 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 911045003241 kynureninase; Region: kynureninase; TIGR01814 911045003242 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045003243 catalytic residue [active] 911045003244 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 911045003245 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045003246 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 911045003247 Walker A/P-loop; other site 911045003248 ATP binding site [chemical binding]; other site 911045003249 Q-loop/lid; other site 911045003250 ABC transporter signature motif; other site 911045003251 Walker B; other site 911045003252 D-loop; other site 911045003253 H-loop/switch region; other site 911045003254 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045003255 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 911045003256 Walker A/P-loop; other site 911045003257 ATP binding site [chemical binding]; other site 911045003258 Q-loop/lid; other site 911045003259 ABC transporter signature motif; other site 911045003260 Walker B; other site 911045003261 D-loop; other site 911045003262 H-loop/switch region; other site 911045003263 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045003264 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045003265 TM-ABC transporter signature motif; other site 911045003266 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045003267 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045003268 TM-ABC transporter signature motif; other site 911045003269 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 911045003270 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 911045003271 putative ligand binding site [chemical binding]; other site 911045003272 Hemin uptake protein hemP; Region: hemP; pfam10636 911045003273 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 911045003274 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 911045003275 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 911045003276 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 911045003277 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 911045003278 Transcriptional regulator; Region: Rrf2; cl17282 911045003279 Predicted transcriptional regulator [Transcription]; Region: COG1959 911045003280 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 911045003281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045003282 DNA-binding site [nucleotide binding]; DNA binding site 911045003283 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 911045003284 BCCT family transporter; Region: BCCT; cl00569 911045003285 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 911045003286 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 911045003287 active site pocket [active] 911045003288 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 911045003289 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 911045003290 SnoaL-like domain; Region: SnoaL_2; pfam12680 911045003291 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045003292 EamA-like transporter family; Region: EamA; pfam00892 911045003293 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 911045003294 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 911045003295 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 911045003296 putative dimer interface [polypeptide binding]; other site 911045003297 N-terminal domain interface [polypeptide binding]; other site 911045003298 putative substrate binding pocket (H-site) [chemical binding]; other site 911045003299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045003300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045003301 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 911045003302 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045003303 N-terminal plug; other site 911045003304 ligand-binding site [chemical binding]; other site 911045003305 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 911045003306 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 911045003307 siderophore binding site; other site 911045003308 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 911045003309 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045003310 ABC-ATPase subunit interface; other site 911045003311 dimer interface [polypeptide binding]; other site 911045003312 putative PBP binding regions; other site 911045003313 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 911045003314 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045003315 ABC-ATPase subunit interface; other site 911045003316 dimer interface [polypeptide binding]; other site 911045003317 putative PBP binding regions; other site 911045003318 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 911045003319 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045003320 Walker A/P-loop; other site 911045003321 ATP binding site [chemical binding]; other site 911045003322 Q-loop/lid; other site 911045003323 ABC transporter signature motif; other site 911045003324 Walker B; other site 911045003325 D-loop; other site 911045003326 H-loop/switch region; other site 911045003327 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 911045003328 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 911045003329 FAD binding pocket [chemical binding]; other site 911045003330 FAD binding motif [chemical binding]; other site 911045003331 phosphate binding motif [ion binding]; other site 911045003332 NAD binding pocket [chemical binding]; other site 911045003333 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 911045003334 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 911045003335 G1 box; other site 911045003336 GTP/Mg2+ binding site [chemical binding]; other site 911045003337 Switch I region; other site 911045003338 G2 box; other site 911045003339 G3 box; other site 911045003340 Switch II region; other site 911045003341 G4 box; other site 911045003342 G5 box; other site 911045003343 Nucleoside recognition; Region: Gate; pfam07670 911045003344 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 911045003345 Nucleoside recognition; Region: Gate; pfam07670 911045003346 FeoA domain; Region: FeoA; pfam04023 911045003347 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 911045003348 muropeptide transporter; Validated; Region: ampG; cl17669 911045003349 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 911045003350 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045003351 N-terminal plug; other site 911045003352 ligand-binding site [chemical binding]; other site 911045003353 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 911045003354 Carbon starvation protein CstA; Region: CstA; pfam02554 911045003355 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 911045003356 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 911045003357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045003358 active site 911045003359 phosphorylation site [posttranslational modification] 911045003360 intermolecular recognition site; other site 911045003361 dimerization interface [polypeptide binding]; other site 911045003362 LytTr DNA-binding domain; Region: LytTR; smart00850 911045003363 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 911045003364 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 911045003365 Histidine kinase; Region: His_kinase; pfam06580 911045003366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045003367 ATP binding site [chemical binding]; other site 911045003368 Mg2+ binding site [ion binding]; other site 911045003369 G-X-G motif; other site 911045003370 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045003371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045003372 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045003373 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 911045003374 metal-binding site 911045003375 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 911045003376 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 911045003377 active site 911045003378 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 911045003379 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 911045003380 putative metal binding site; other site 911045003381 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 911045003382 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045003383 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 911045003384 transcriptional activator RfaH; Region: RfaH; TIGR01955 911045003385 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 911045003386 heterodimer interface [polypeptide binding]; other site 911045003387 homodimer interface [polypeptide binding]; other site 911045003388 Bacterial sugar transferase; Region: Bac_transf; pfam02397 911045003389 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 911045003390 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 911045003391 Chain length determinant protein; Region: Wzz; pfam02706 911045003392 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045003393 P-loop; other site 911045003394 Magnesium ion binding site [ion binding]; other site 911045003395 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 911045003396 active site 911045003397 metal binding site [ion binding]; metal-binding site 911045003398 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 911045003399 O-Antigen ligase; Region: Wzy_C; pfam04932 911045003400 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 911045003401 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 911045003402 SLBB domain; Region: SLBB; pfam10531 911045003403 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 911045003404 active site 911045003405 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 911045003406 Transposase; Region: HTH_Tnp_1; pfam01527 911045003407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 911045003408 Helix-turn-helix domain; Region: HTH_28; pfam13518 911045003409 Winged helix-turn helix; Region: HTH_29; pfam13551 911045003410 Homeodomain-like domain; Region: HTH_32; pfam13565 911045003411 Integrase core domain; Region: rve; pfam00665 911045003412 Integrase core domain; Region: rve_3; pfam13683 911045003413 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 911045003414 homotrimer interaction site [polypeptide binding]; other site 911045003415 putative active site [active] 911045003416 Protein of unknown function (DUF3726); Region: DUF3726; pfam12525 911045003417 BCCT family transporter; Region: BCCT; pfam02028 911045003418 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045003419 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 911045003420 active site 911045003421 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 911045003422 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045003423 NAD(P) binding site [chemical binding]; other site 911045003424 catalytic residues [active] 911045003425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045003426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045003427 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 911045003428 putative dimerization interface [polypeptide binding]; other site 911045003429 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 911045003430 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045003431 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045003432 catalytic residue [active] 911045003433 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045003434 homotrimer interaction site [polypeptide binding]; other site 911045003435 putative active site [active] 911045003436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 911045003437 YheO-like PAS domain; Region: PAS_6; pfam08348 911045003438 HTH domain; Region: HTH_22; pfam13309 911045003439 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045003440 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045003441 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 911045003442 active site 911045003443 BCCT family transporter; Region: BCCT; pfam02028 911045003444 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 911045003445 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 911045003446 metal binding site [ion binding]; metal-binding site 911045003447 putative dimer interface [polypeptide binding]; other site 911045003448 RHS Repeat; Region: RHS_repeat; pfam05593 911045003449 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 911045003450 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 911045003451 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 911045003452 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 911045003453 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 911045003454 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 911045003455 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045003456 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045003457 ligand binding site [chemical binding]; other site 911045003458 flexible hinge region; other site 911045003459 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 911045003460 Autotransporter beta-domain; Region: Autotransporter; pfam03797 911045003461 Helix-turn-helix domain; Region: HTH_28; pfam13518 911045003462 Winged helix-turn helix; Region: HTH_29; pfam13551 911045003463 Homeodomain-like domain; Region: HTH_32; pfam13565 911045003464 Integrase core domain; Region: rve; pfam00665 911045003465 Integrase core domain; Region: rve_3; pfam13683 911045003466 Transposase; Region: HTH_Tnp_1; pfam01527 911045003467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 911045003468 Predicted flavoproteins [General function prediction only]; Region: COG2081 911045003469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 911045003470 Nitrate and nitrite sensing; Region: NIT; pfam08376 911045003471 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 911045003472 HAMP domain; Region: HAMP; pfam00672 911045003473 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045003474 dimer interface [polypeptide binding]; other site 911045003475 putative CheW interface [polypeptide binding]; other site 911045003476 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045003477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045003478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045003479 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 911045003480 DNA-binding site [nucleotide binding]; DNA binding site 911045003481 RNA-binding motif; other site 911045003482 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 911045003483 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045003484 TM-ABC transporter signature motif; other site 911045003485 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 911045003486 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045003487 TM-ABC transporter signature motif; other site 911045003488 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045003489 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 911045003490 Walker A/P-loop; other site 911045003491 ATP binding site [chemical binding]; other site 911045003492 Q-loop/lid; other site 911045003493 ABC transporter signature motif; other site 911045003494 Walker B; other site 911045003495 D-loop; other site 911045003496 H-loop/switch region; other site 911045003497 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045003498 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 911045003499 Walker A/P-loop; other site 911045003500 ATP binding site [chemical binding]; other site 911045003501 Q-loop/lid; other site 911045003502 ABC transporter signature motif; other site 911045003503 Walker B; other site 911045003504 D-loop; other site 911045003505 H-loop/switch region; other site 911045003506 bile acid transporter; Region: bass; TIGR00841 911045003507 Sodium Bile acid symporter family; Region: SBF; cl17470 911045003508 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045003509 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 911045003510 putative ligand binding site [chemical binding]; other site 911045003511 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 911045003512 active site residue [active] 911045003513 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 911045003514 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 911045003515 conserved cys residue [active] 911045003516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045003517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045003518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 911045003519 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 911045003520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045003521 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045003522 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 911045003523 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045003524 active site 911045003525 metal binding site [ion binding]; metal-binding site 911045003526 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045003527 active site 911045003528 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 911045003529 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 911045003530 putative metal binding site; other site 911045003531 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 911045003532 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 911045003533 active site 911045003534 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 911045003535 homotrimer interaction site [polypeptide binding]; other site 911045003536 putative active site [active] 911045003537 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045003538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045003539 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045003540 dimerization interface [polypeptide binding]; other site 911045003541 substrate binding pocket [chemical binding]; other site 911045003542 siroheme synthase; Provisional; Region: cysG; PRK10637 911045003543 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 911045003544 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 911045003545 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 911045003546 active site 911045003547 SAM binding site [chemical binding]; other site 911045003548 homodimer interface [polypeptide binding]; other site 911045003549 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 911045003550 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 911045003551 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 911045003552 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 911045003553 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 911045003554 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 911045003555 Active Sites [active] 911045003556 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 911045003557 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 911045003558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045003559 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 911045003560 Walker A/P-loop; other site 911045003561 ATP binding site [chemical binding]; other site 911045003562 Q-loop/lid; other site 911045003563 ABC transporter signature motif; other site 911045003564 Walker B; other site 911045003565 D-loop; other site 911045003566 H-loop/switch region; other site 911045003567 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045003568 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 911045003569 NAD(P) binding site [chemical binding]; other site 911045003570 catalytic residues [active] 911045003571 catalytic residues [active] 911045003572 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 911045003573 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 911045003574 putative NAD(P) binding site [chemical binding]; other site 911045003575 active site 911045003576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045003577 active site 911045003578 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 911045003579 phosphorylation site [posttranslational modification] 911045003580 intermolecular recognition site; other site 911045003581 dimerization interface [polypeptide binding]; other site 911045003582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045003583 active site 911045003584 phosphorylation site [posttranslational modification] 911045003585 intermolecular recognition site; other site 911045003586 dimerization interface [polypeptide binding]; other site 911045003587 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045003588 metal binding site [ion binding]; metal-binding site 911045003589 active site 911045003590 I-site; other site 911045003591 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 911045003592 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 911045003593 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 911045003594 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 911045003595 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045003596 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 911045003597 Walker A/P-loop; other site 911045003598 ATP binding site [chemical binding]; other site 911045003599 Q-loop/lid; other site 911045003600 ABC transporter signature motif; other site 911045003601 Walker B; other site 911045003602 D-loop; other site 911045003603 H-loop/switch region; other site 911045003604 TOBE domain; Region: TOBE_2; pfam08402 911045003605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003606 dimer interface [polypeptide binding]; other site 911045003607 conserved gate region; other site 911045003608 putative PBP binding loops; other site 911045003609 ABC-ATPase subunit interface; other site 911045003610 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045003611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003612 dimer interface [polypeptide binding]; other site 911045003613 conserved gate region; other site 911045003614 putative PBP binding loops; other site 911045003615 ABC-ATPase subunit interface; other site 911045003616 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 911045003617 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 911045003618 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608 911045003619 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045003620 homotrimer interaction site [polypeptide binding]; other site 911045003621 putative active site [active] 911045003622 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045003623 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 911045003624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003625 dimer interface [polypeptide binding]; other site 911045003626 conserved gate region; other site 911045003627 putative PBP binding loops; other site 911045003628 ABC-ATPase subunit interface; other site 911045003629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045003630 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 911045003631 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045003632 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045003633 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045003634 tetramer interface [polypeptide binding]; other site 911045003635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045003636 catalytic residue [active] 911045003637 PAS domain; Region: PAS_9; pfam13426 911045003638 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 911045003639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045003640 putative active site [active] 911045003641 heme pocket [chemical binding]; other site 911045003642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045003643 dimer interface [polypeptide binding]; other site 911045003644 phosphorylation site [posttranslational modification] 911045003645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045003646 ATP binding site [chemical binding]; other site 911045003647 Mg2+ binding site [ion binding]; other site 911045003648 G-X-G motif; other site 911045003649 Phasin protein; Region: Phasin_2; cl11491 911045003650 Phasin protein; Region: Phasin_2; cl11491 911045003651 Carboxylesterase family; Region: COesterase; pfam00135 911045003652 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 911045003653 substrate binding pocket [chemical binding]; other site 911045003654 catalytic triad [active] 911045003655 putative outer membrane lipoprotein; Provisional; Region: PRK10510 911045003656 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045003657 ligand binding site [chemical binding]; other site 911045003658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045003659 S-adenosylmethionine binding site [chemical binding]; other site 911045003660 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045003661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045003662 putative substrate translocation pore; other site 911045003663 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 911045003664 putative homodimer interface [polypeptide binding]; other site 911045003665 putative homotetramer interface [polypeptide binding]; other site 911045003666 putative metal binding site [ion binding]; other site 911045003667 putative homodimer-homodimer interface [polypeptide binding]; other site 911045003668 putative allosteric switch controlling residues; other site 911045003669 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 911045003670 active site 911045003671 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045003672 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 911045003673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045003674 DNA-binding site [nucleotide binding]; DNA binding site 911045003675 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045003676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045003677 homodimer interface [polypeptide binding]; other site 911045003678 catalytic residue [active] 911045003679 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 911045003680 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 911045003681 ligand binding site [chemical binding]; other site 911045003682 Transglycosylase SLT domain; Region: SLT_2; pfam13406 911045003683 murein hydrolase B; Provisional; Region: PRK10760; cl17906 911045003684 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cd00159 911045003685 GTPase interaction site; other site 911045003686 catalytic residue [active] 911045003687 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045003688 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045003689 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 911045003690 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 911045003691 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 911045003692 homodimer interface [polypeptide binding]; other site 911045003693 NADP binding site [chemical binding]; other site 911045003694 substrate binding site [chemical binding]; other site 911045003695 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 911045003696 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 911045003697 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 911045003698 putative active site [active] 911045003699 putative substrate binding site [chemical binding]; other site 911045003700 putative cosubstrate binding site; other site 911045003701 catalytic site [active] 911045003702 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045003703 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 911045003704 putative ADP-binding pocket [chemical binding]; other site 911045003705 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 911045003706 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045003707 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045003708 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045003709 multidrug efflux protein; Reviewed; Region: PRK09579 911045003710 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 911045003711 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 911045003712 FAD binding domain; Region: FAD_binding_4; pfam01565 911045003713 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 911045003714 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 911045003715 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 911045003716 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 911045003717 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 911045003718 acyl-activating enzyme (AAE) consensus motif; other site 911045003719 acyl-activating enzyme (AAE) consensus motif; other site 911045003720 putative AMP binding site [chemical binding]; other site 911045003721 putative active site [active] 911045003722 putative CoA binding site [chemical binding]; other site 911045003723 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045003724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045003725 Coenzyme A binding pocket [chemical binding]; other site 911045003726 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045003727 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 911045003728 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 911045003729 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 911045003730 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 911045003731 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 911045003732 Cupin domain; Region: Cupin_2; cl17218 911045003733 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045003734 Radical SAM superfamily; Region: Radical_SAM; pfam04055 911045003735 FeS/SAM binding site; other site 911045003736 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045003737 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045003738 Walker A/P-loop; other site 911045003739 ATP binding site [chemical binding]; other site 911045003740 Q-loop/lid; other site 911045003741 ABC transporter signature motif; other site 911045003742 Walker B; other site 911045003743 D-loop; other site 911045003744 H-loop/switch region; other site 911045003745 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 911045003746 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045003747 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045003748 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045003749 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045003750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003751 dimer interface [polypeptide binding]; other site 911045003752 conserved gate region; other site 911045003753 putative PBP binding loops; other site 911045003754 ABC-ATPase subunit interface; other site 911045003755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045003756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003757 dimer interface [polypeptide binding]; other site 911045003758 conserved gate region; other site 911045003759 putative PBP binding loops; other site 911045003760 ABC-ATPase subunit interface; other site 911045003761 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 911045003762 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 911045003763 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 911045003764 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 911045003765 active site 911045003766 intersubunit interface [polypeptide binding]; other site 911045003767 catalytic residue [active] 911045003768 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 911045003769 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 911045003770 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 911045003771 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 911045003772 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 911045003773 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 911045003774 Proline dehydrogenase; Region: Pro_dh; pfam01619 911045003775 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 911045003776 Glutamate binding site [chemical binding]; other site 911045003777 NAD binding site [chemical binding]; other site 911045003778 catalytic residues [active] 911045003779 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 911045003780 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045003781 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045003782 putative DNA binding site [nucleotide binding]; other site 911045003783 putative Zn2+ binding site [ion binding]; other site 911045003784 AsnC family; Region: AsnC_trans_reg; pfam01037 911045003785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045003786 Coenzyme A binding pocket [chemical binding]; other site 911045003787 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 911045003788 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 911045003789 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 911045003790 putative substrate binding site [chemical binding]; other site 911045003791 nucleotide binding site [chemical binding]; other site 911045003792 nucleotide binding site [chemical binding]; other site 911045003793 homodimer interface [polypeptide binding]; other site 911045003794 ornithine carbamoyltransferase; Validated; Region: PRK02102 911045003795 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 911045003796 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 911045003797 arginine deiminase; Provisional; Region: PRK01388 911045003798 Predicted membrane protein [Function unknown]; Region: COG1288 911045003799 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 911045003800 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 911045003801 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 911045003802 phosphate binding site [ion binding]; other site 911045003803 putative substrate binding pocket [chemical binding]; other site 911045003804 dimer interface [polypeptide binding]; other site 911045003805 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 911045003806 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 911045003807 acyl-activating enzyme (AAE) consensus motif; other site 911045003808 putative AMP binding site [chemical binding]; other site 911045003809 putative active site [active] 911045003810 putative CoA binding site [chemical binding]; other site 911045003811 Glucuronate isomerase; Region: UxaC; pfam02614 911045003812 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 911045003813 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 911045003814 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 911045003815 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 911045003816 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 911045003817 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 911045003818 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 911045003819 putative active site [active] 911045003820 putative catalytic site [active] 911045003821 DctM-like transporters; Region: DctM; pfam06808 911045003822 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045003823 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045003824 beta-D-glucuronidase; Provisional; Region: PRK10150 911045003825 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 911045003826 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 911045003827 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 911045003828 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 911045003829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045003830 DNA-binding site [nucleotide binding]; DNA binding site 911045003831 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 911045003832 mannonate dehydratase; Provisional; Region: PRK03906 911045003833 mannonate dehydratase; Region: uxuA; TIGR00695 911045003834 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 911045003835 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 911045003836 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 911045003837 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045003838 ABC-ATPase subunit interface; other site 911045003839 dimer interface [polypeptide binding]; other site 911045003840 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 911045003841 metal binding site 2 [ion binding]; metal-binding site 911045003842 putative DNA binding helix; other site 911045003843 metal binding site 1 [ion binding]; metal-binding site 911045003844 dimer interface [polypeptide binding]; other site 911045003845 structural Zn2+ binding site [ion binding]; other site 911045003846 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045003847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045003848 DNA binding residues [nucleotide binding] 911045003849 dimerization interface [polypeptide binding]; other site 911045003850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045003851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045003852 SCP-2 sterol transfer family; Region: SCP2; pfam02036 911045003853 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 911045003854 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 911045003855 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 911045003856 active site 911045003857 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 911045003858 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 911045003859 putative catalytic cysteine [active] 911045003860 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 911045003861 putative active site [active] 911045003862 metal binding site [ion binding]; metal-binding site 911045003863 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 911045003864 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 911045003865 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 911045003866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045003867 DNA-binding site [nucleotide binding]; DNA binding site 911045003868 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045003869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045003870 homodimer interface [polypeptide binding]; other site 911045003871 catalytic residue [active] 911045003872 EamA-like transporter family; Region: EamA; pfam00892 911045003873 Predicted deacylase [General function prediction only]; Region: COG3608 911045003874 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 911045003875 putative active site [active] 911045003876 Zn binding site [ion binding]; other site 911045003877 Methyltransferase domain; Region: Methyltransf_31; pfam13847 911045003878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045003879 S-adenosylmethionine binding site [chemical binding]; other site 911045003880 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 911045003881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045003882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045003883 Protein of unknown function (DUF418); Region: DUF418; pfam04235 911045003884 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 911045003885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045003886 motif II; other site 911045003887 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 911045003888 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 911045003889 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 911045003890 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 911045003891 GIY-YIG motif/motif A; other site 911045003892 putative active site [active] 911045003893 putative metal binding site [ion binding]; other site 911045003894 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 911045003895 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 911045003896 ATP binding site [chemical binding]; other site 911045003897 Mg++ binding site [ion binding]; other site 911045003898 motif III; other site 911045003899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045003900 nucleotide binding region [chemical binding]; other site 911045003901 ATP-binding site [chemical binding]; other site 911045003902 Cupin domain; Region: Cupin_2; cl17218 911045003903 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 911045003904 MgtE intracellular N domain; Region: MgtE_N; smart00924 911045003905 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 911045003906 Divalent cation transporter; Region: MgtE; pfam01769 911045003907 PBP superfamily domain; Region: PBP_like_2; cl17296 911045003908 BCCT family transporter; Region: BCCT; pfam02028 911045003909 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045003910 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 911045003911 active site 911045003912 catalytic tetrad [active] 911045003913 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045003914 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 911045003915 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 911045003916 Cytochrome c2 [Energy production and conversion]; Region: COG3474 911045003917 Cytochrome c; Region: Cytochrom_C; cl11414 911045003918 Cytochrome c; Region: Cytochrom_C; pfam00034 911045003919 Cytochrome c2 [Energy production and conversion]; Region: COG3474 911045003920 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 911045003921 Moco binding site; other site 911045003922 metal coordination site [ion binding]; other site 911045003923 dimerization interface [polypeptide binding]; other site 911045003924 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 911045003925 active site 911045003926 metal binding site [ion binding]; metal-binding site 911045003927 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045003928 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 911045003929 Cytochrome c [Energy production and conversion]; Region: COG3258 911045003930 Cytochrome c [Energy production and conversion]; Region: COG3258 911045003931 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 911045003932 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 911045003933 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 911045003934 Cytochrome c; Region: Cytochrom_C; pfam00034 911045003935 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 911045003936 catalytic residues [active] 911045003937 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 911045003938 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 911045003939 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045003940 Domain of unknown function (DUF336); Region: DUF336; pfam03928 911045003941 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045003942 dimerization interface [polypeptide binding]; other site 911045003943 putative DNA binding site [nucleotide binding]; other site 911045003944 putative Zn2+ binding site [ion binding]; other site 911045003945 Sulphur transport; Region: Sulf_transp; pfam04143 911045003946 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 911045003947 Isochorismatase family; Region: Isochorismatase; pfam00857 911045003948 catalytic triad [active] 911045003949 metal binding site [ion binding]; metal-binding site 911045003950 conserved cis-peptide bond; other site 911045003951 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 911045003952 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 911045003953 active site 911045003954 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 911045003955 FAD binding domain; Region: FAD_binding_4; pfam01565 911045003956 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 911045003957 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 911045003958 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 911045003959 putative N- and C-terminal domain interface [polypeptide binding]; other site 911045003960 putative active site [active] 911045003961 MgATP binding site [chemical binding]; other site 911045003962 catalytic site [active] 911045003963 metal binding site [ion binding]; metal-binding site 911045003964 putative carbohydrate binding site [chemical binding]; other site 911045003965 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 911045003966 Transcriptional activator [Transcription]; Region: ChrR; COG3806 911045003967 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 911045003968 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 911045003969 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 911045003970 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 911045003971 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 911045003972 Predicted flavoprotein [General function prediction only]; Region: COG0431 911045003973 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045003974 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045003975 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045003976 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 911045003977 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 911045003978 active site 911045003979 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 911045003980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045003981 DNA-binding site [nucleotide binding]; DNA binding site 911045003982 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 911045003983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003984 dimer interface [polypeptide binding]; other site 911045003985 conserved gate region; other site 911045003986 putative PBP binding loops; other site 911045003987 ABC-ATPase subunit interface; other site 911045003988 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045003989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045003990 dimer interface [polypeptide binding]; other site 911045003991 conserved gate region; other site 911045003992 putative PBP binding loops; other site 911045003993 ABC-ATPase subunit interface; other site 911045003994 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045003995 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045003996 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 911045003997 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045003998 Walker A/P-loop; other site 911045003999 ATP binding site [chemical binding]; other site 911045004000 Q-loop/lid; other site 911045004001 ABC transporter signature motif; other site 911045004002 Walker B; other site 911045004003 D-loop; other site 911045004004 H-loop/switch region; other site 911045004005 TOBE domain; Region: TOBE_2; pfam08402 911045004006 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045004007 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045004008 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 911045004009 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 911045004010 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 911045004011 dimer interface [polypeptide binding]; other site 911045004012 active site 911045004013 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 911045004014 dimer interface [polypeptide binding]; other site 911045004015 active site 911045004016 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 911045004017 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 911045004018 dimer interface [polypeptide binding]; other site 911045004019 active site 911045004020 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 911045004021 fructokinase; Reviewed; Region: PRK09557 911045004022 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 911045004023 nucleotide binding site [chemical binding]; other site 911045004024 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 911045004025 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 911045004026 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045004027 active site 911045004028 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045004029 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045004030 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045004031 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 911045004032 putative active site [active] 911045004033 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 911045004034 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045004035 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 911045004036 Walker A/P-loop; other site 911045004037 ATP binding site [chemical binding]; other site 911045004038 Q-loop/lid; other site 911045004039 ABC transporter signature motif; other site 911045004040 Walker B; other site 911045004041 D-loop; other site 911045004042 H-loop/switch region; other site 911045004043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045004044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045004045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045004046 dimerization interface [polypeptide binding]; other site 911045004047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004048 NAD(P) binding site [chemical binding]; other site 911045004049 active site 911045004050 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 911045004051 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 911045004052 catalytic triad [active] 911045004053 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 911045004054 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045004055 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 911045004056 classical (c) SDRs; Region: SDR_c; cd05233 911045004057 NAD(P) binding site [chemical binding]; other site 911045004058 active site 911045004059 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 911045004060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 911045004061 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 911045004062 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045004063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045004064 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 911045004065 oligomerization interface [polypeptide binding]; other site 911045004066 active site 911045004067 metal binding site [ion binding]; metal-binding site 911045004068 Isochorismatase family; Region: Isochorismatase; pfam00857 911045004069 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 911045004070 catalytic triad [active] 911045004071 conserved cis-peptide bond; other site 911045004072 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 911045004073 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045004074 active site 911045004075 metal binding site [ion binding]; metal-binding site 911045004076 hexamer interface [polypeptide binding]; other site 911045004077 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 911045004078 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 911045004079 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 911045004080 Protein of unknown function (DUF805); Region: DUF805; pfam05656 911045004081 Protein of unknown function (DUF805); Region: DUF805; pfam05656 911045004082 FeoC like transcriptional regulator; Region: FeoC; cl17677 911045004083 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 911045004084 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 911045004085 G1 box; other site 911045004086 GTP/Mg2+ binding site [chemical binding]; other site 911045004087 G2 box; other site 911045004088 Switch I region; other site 911045004089 G3 box; other site 911045004090 Switch II region; other site 911045004091 G4 box; other site 911045004092 Nucleoside recognition; Region: Gate; pfam07670 911045004093 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 911045004094 Nucleoside recognition; Region: Gate; pfam07670 911045004095 FeoA domain; Region: FeoA; pfam04023 911045004096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 911045004097 Predicted kinase [General function prediction only]; Region: COG0645 911045004098 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 911045004099 active site 911045004100 thiamine pyrophosphate protein; Validated; Region: PRK08199 911045004101 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045004102 PYR/PP interface [polypeptide binding]; other site 911045004103 dimer interface [polypeptide binding]; other site 911045004104 TPP binding site [chemical binding]; other site 911045004105 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 911045004106 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 911045004107 TPP-binding site [chemical binding]; other site 911045004108 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 911045004109 CoA binding domain; Region: CoA_binding_2; pfam13380 911045004110 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 911045004111 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 911045004112 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045004113 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045004114 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 911045004115 Ligand Binding Site [chemical binding]; other site 911045004116 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045004117 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045004118 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045004119 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045004120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045004121 Coenzyme A binding pocket [chemical binding]; other site 911045004122 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 911045004123 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 911045004124 generic binding surface II; other site 911045004125 generic binding surface I; other site 911045004126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 911045004127 RNA methyltransferase, RsmE family; Region: TIGR00046 911045004128 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 911045004129 cyclase homology domain; Region: CHD; cd07302 911045004130 nucleotidyl binding site; other site 911045004131 metal binding site [ion binding]; metal-binding site 911045004132 dimer interface [polypeptide binding]; other site 911045004133 conjugal transfer protein TraD; Provisional; Region: PRK13700 911045004134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045004135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045004136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045004137 dimerization interface [polypeptide binding]; other site 911045004138 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 911045004139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045004140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045004141 dimerization interface [polypeptide binding]; other site 911045004142 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045004143 EamA-like transporter family; Region: EamA; cl17759 911045004144 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 911045004145 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 911045004146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045004147 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045004148 substrate binding pocket [chemical binding]; other site 911045004149 membrane-bound complex binding site; other site 911045004150 hinge residues; other site 911045004151 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045004152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045004153 dimer interface [polypeptide binding]; other site 911045004154 conserved gate region; other site 911045004155 putative PBP binding loops; other site 911045004156 ABC-ATPase subunit interface; other site 911045004157 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 911045004158 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 911045004159 catalytic triad [active] 911045004160 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045004161 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045004162 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045004163 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 911045004164 N-terminal domain interface [polypeptide binding]; other site 911045004165 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045004166 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 911045004167 C-terminal domain interface [polypeptide binding]; other site 911045004168 GSH binding site (G-site) [chemical binding]; other site 911045004169 dimer interface [polypeptide binding]; other site 911045004170 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 911045004171 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045004172 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 911045004173 putative C-terminal domain interface [polypeptide binding]; other site 911045004174 putative GSH binding site (G-site) [chemical binding]; other site 911045004175 putative dimer interface [polypeptide binding]; other site 911045004176 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 911045004177 putative N-terminal domain interface [polypeptide binding]; other site 911045004178 putative dimer interface [polypeptide binding]; other site 911045004179 putative substrate binding pocket (H-site) [chemical binding]; other site 911045004180 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 911045004181 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045004182 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 911045004183 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 911045004184 catalytic residues [active] 911045004185 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045004186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045004187 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045004188 putative effector binding pocket; other site 911045004189 dimerization interface [polypeptide binding]; other site 911045004190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045004191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045004192 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045004193 dimerization interface [polypeptide binding]; other site 911045004194 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 911045004195 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 911045004196 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 911045004197 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 911045004198 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 911045004199 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 911045004200 active site 911045004201 intersubunit interface [polypeptide binding]; other site 911045004202 zinc binding site [ion binding]; other site 911045004203 Na+ binding site [ion binding]; other site 911045004204 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 911045004205 Cysteine-rich domain; Region: CCG; pfam02754 911045004206 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 911045004207 dimer interface [polypeptide binding]; other site 911045004208 FMN binding site [chemical binding]; other site 911045004209 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045004210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045004211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045004212 Coenzyme A binding pocket [chemical binding]; other site 911045004213 Cytochrome c2 [Energy production and conversion]; Region: COG3474 911045004214 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 911045004215 FAD binding domain; Region: FAD_binding_4; pfam01565 911045004216 FAD binding domain; Region: FAD_binding_4; pfam01565 911045004217 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 911045004218 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 911045004219 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 911045004220 Cysteine-rich domain; Region: CCG; pfam02754 911045004221 Cysteine-rich domain; Region: CCG; pfam02754 911045004222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 911045004223 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 911045004224 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 911045004225 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 911045004226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045004227 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045004228 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045004229 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 911045004230 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045004231 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 911045004232 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 911045004233 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 911045004234 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 911045004235 motif 1; other site 911045004236 dimer interface [polypeptide binding]; other site 911045004237 active site 911045004238 motif 2; other site 911045004239 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 911045004240 active site 911045004241 motif 3; other site 911045004242 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 911045004243 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 911045004244 dimer interface [polypeptide binding]; other site 911045004245 motif 1; other site 911045004246 active site 911045004247 motif 2; other site 911045004248 motif 3; other site 911045004249 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 911045004250 anticodon binding site; other site 911045004251 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 911045004252 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 911045004253 Ligand binding site; other site 911045004254 Putative Catalytic site; other site 911045004255 DXD motif; other site 911045004256 Predicted membrane protein [Function unknown]; Region: COG2246 911045004257 GtrA-like protein; Region: GtrA; pfam04138 911045004258 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 911045004259 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 911045004260 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 911045004261 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045004262 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045004263 ligand binding site [chemical binding]; other site 911045004264 flexible hinge region; other site 911045004265 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 911045004266 putative switch regulator; other site 911045004267 non-specific DNA interactions [nucleotide binding]; other site 911045004268 DNA binding site [nucleotide binding] 911045004269 sequence specific DNA binding site [nucleotide binding]; other site 911045004270 putative cAMP binding site [chemical binding]; other site 911045004271 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 911045004272 heme-binding site [chemical binding]; other site 911045004273 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 911045004274 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 911045004275 heme-binding site [chemical binding]; other site 911045004276 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 911045004277 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 911045004278 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 911045004279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045004280 Coenzyme A binding pocket [chemical binding]; other site 911045004281 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 911045004282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045004283 putative substrate translocation pore; other site 911045004284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045004285 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 911045004286 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 911045004287 ring oligomerisation interface [polypeptide binding]; other site 911045004288 ATP/Mg binding site [chemical binding]; other site 911045004289 stacking interactions; other site 911045004290 hinge regions; other site 911045004291 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 911045004292 oligomerisation interface [polypeptide binding]; other site 911045004293 mobile loop; other site 911045004294 roof hairpin; other site 911045004295 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 911045004296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004297 active site 911045004298 phosphorylation site [posttranslational modification] 911045004299 intermolecular recognition site; other site 911045004300 dimerization interface [polypeptide binding]; other site 911045004301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045004302 Walker A motif; other site 911045004303 ATP binding site [chemical binding]; other site 911045004304 Walker B motif; other site 911045004305 arginine finger; other site 911045004306 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 911045004307 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045004308 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045004309 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 911045004310 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045004311 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045004312 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 911045004313 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045004314 lipoprotein signal peptidase; Provisional; Region: PRK14796 911045004315 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 911045004316 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045004317 active site 911045004318 HIGH motif; other site 911045004319 nucleotide binding site [chemical binding]; other site 911045004320 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 911045004321 active site 911045004322 KMSKS motif; other site 911045004323 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 911045004324 tRNA binding surface [nucleotide binding]; other site 911045004325 anticodon binding site; other site 911045004326 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045004327 EamA-like transporter family; Region: EamA; pfam00892 911045004328 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045004329 EamA-like transporter family; Region: EamA; pfam00892 911045004330 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 911045004331 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 911045004332 active site 911045004333 Riboflavin kinase; Region: Flavokinase; smart00904 911045004334 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 911045004335 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 911045004336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004337 active site 911045004338 phosphorylation site [posttranslational modification] 911045004339 intermolecular recognition site; other site 911045004340 dimerization interface [polypeptide binding]; other site 911045004341 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 911045004342 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 911045004343 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 911045004344 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 911045004345 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 911045004346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045004347 ATP binding site [chemical binding]; other site 911045004348 Mg2+ binding site [ion binding]; other site 911045004349 G-X-G motif; other site 911045004350 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 911045004351 ATP binding site [chemical binding]; other site 911045004352 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 911045004353 Porin subfamily; Region: Porin_2; pfam02530 911045004354 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 911045004355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 911045004356 S-adenosylmethionine binding site [chemical binding]; other site 911045004357 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 911045004358 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045004359 RNA binding surface [nucleotide binding]; other site 911045004360 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 911045004361 active site 911045004362 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 911045004363 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 911045004364 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 911045004365 nucleoside/Zn binding site; other site 911045004366 dimer interface [polypeptide binding]; other site 911045004367 catalytic motif [active] 911045004368 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045004369 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 911045004370 EamA-like transporter family; Region: EamA; pfam00892 911045004371 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045004372 Cupin domain; Region: Cupin_2; cl17218 911045004373 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045004374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045004375 MarC family integral membrane protein; Region: MarC; cl00919 911045004376 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 911045004377 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 911045004378 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045004379 catalytic residue [active] 911045004380 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045004381 active site 911045004382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045004383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045004384 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045004385 dimerization interface [polypeptide binding]; other site 911045004386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004387 NAD(P) binding site [chemical binding]; other site 911045004388 active site 911045004389 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 911045004390 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 911045004391 putative molybdopterin cofactor binding site [chemical binding]; other site 911045004392 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 911045004393 putative molybdopterin cofactor binding site; other site 911045004394 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 911045004395 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 911045004396 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 911045004397 nucleophile elbow; other site 911045004398 Autoinducer binding domain; Region: Autoind_bind; pfam03472 911045004399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045004400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045004401 DNA binding residues [nucleotide binding] 911045004402 dimerization interface [polypeptide binding]; other site 911045004403 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 911045004404 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 911045004405 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 911045004406 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 911045004407 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 911045004408 UbiA prenyltransferase family; Region: UbiA; pfam01040 911045004409 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 911045004410 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 911045004411 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 911045004412 active site 911045004413 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 911045004414 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 911045004415 putative acyl-acceptor binding pocket; other site 911045004416 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 911045004417 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 911045004418 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 911045004419 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 911045004420 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 911045004421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 911045004422 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 911045004423 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045004424 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 911045004425 DNA binding residues [nucleotide binding] 911045004426 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 911045004427 dimer interface [polypeptide binding]; other site 911045004428 putative metal binding site [ion binding]; other site 911045004429 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 911045004430 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 911045004431 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 911045004432 TrkA-N domain; Region: TrkA_N; pfam02254 911045004433 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 911045004434 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 911045004435 TrkA-N domain; Region: TrkA_N; pfam02254 911045004436 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 911045004437 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 911045004438 protease TldD; Provisional; Region: tldD; PRK10735 911045004439 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045004440 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045004441 DinB family; Region: DinB; cl17821 911045004442 DinB superfamily; Region: DinB_2; pfam12867 911045004443 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 911045004444 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 911045004445 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 911045004446 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 911045004447 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 911045004448 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 911045004449 Subunit I/III interface [polypeptide binding]; other site 911045004450 D-pathway; other site 911045004451 Subunit I/VIIc interface [polypeptide binding]; other site 911045004452 Subunit I/IV interface [polypeptide binding]; other site 911045004453 Subunit I/II interface [polypeptide binding]; other site 911045004454 Low-spin heme (heme a) binding site [chemical binding]; other site 911045004455 Subunit I/VIIa interface [polypeptide binding]; other site 911045004456 Subunit I/VIa interface [polypeptide binding]; other site 911045004457 Dimer interface; other site 911045004458 Putative water exit pathway; other site 911045004459 Binuclear center (heme a3/CuB) [ion binding]; other site 911045004460 K-pathway; other site 911045004461 Subunit I/Vb interface [polypeptide binding]; other site 911045004462 Putative proton exit pathway; other site 911045004463 Subunit I/VIb interface; other site 911045004464 Subunit I/VIc interface [polypeptide binding]; other site 911045004465 Electron transfer pathway; other site 911045004466 Subunit I/VIIIb interface [polypeptide binding]; other site 911045004467 Subunit I/VIIb interface [polypeptide binding]; other site 911045004468 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 911045004469 UbiA prenyltransferase family; Region: UbiA; pfam01040 911045004470 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 911045004471 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 911045004472 Subunit III/VIIa interface [polypeptide binding]; other site 911045004473 Phospholipid binding site [chemical binding]; other site 911045004474 Subunit I/III interface [polypeptide binding]; other site 911045004475 Subunit III/VIb interface [polypeptide binding]; other site 911045004476 Subunit III/VIa interface; other site 911045004477 Subunit III/Vb interface [polypeptide binding]; other site 911045004478 Protein of unknown function (DUF983); Region: DUF983; cl02211 911045004479 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 911045004480 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 911045004481 catalytic triad [active] 911045004482 dimer interface [polypeptide binding]; other site 911045004483 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 911045004484 hypothetical protein; Validated; Region: PRK00228 911045004485 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 911045004486 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 911045004487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045004488 catalytic residue [active] 911045004489 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045004490 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 911045004491 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045004492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045004493 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 911045004494 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 911045004495 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 911045004496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045004497 PAS fold; Region: PAS_3; pfam08447 911045004498 putative active site [active] 911045004499 heme pocket [chemical binding]; other site 911045004500 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 911045004501 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045004502 metal binding site [ion binding]; metal-binding site 911045004503 active site 911045004504 I-site; other site 911045004505 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045004506 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 911045004507 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 911045004508 PilZ domain; Region: PilZ; pfam07238 911045004509 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 911045004510 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 911045004511 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 911045004512 RNA/DNA hybrid binding site [nucleotide binding]; other site 911045004513 active site 911045004514 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 911045004515 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 911045004516 putative active site [active] 911045004517 putative substrate binding site [chemical binding]; other site 911045004518 ATP binding site [chemical binding]; other site 911045004519 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 911045004520 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 911045004521 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 911045004522 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045004523 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 911045004524 lipoyl attachment site [posttranslational modification]; other site 911045004525 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 911045004526 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 911045004527 tetramer interface [polypeptide binding]; other site 911045004528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045004529 catalytic residue [active] 911045004530 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 911045004531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045004532 catalytic residue [active] 911045004533 Protein of unknown function (DUF563); Region: DUF563; pfam04577 911045004534 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 911045004535 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 911045004536 GDP-Fucose binding site [chemical binding]; other site 911045004537 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 911045004538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045004539 motif II; other site 911045004540 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 911045004541 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 911045004542 active site 911045004543 HIGH motif; other site 911045004544 dimer interface [polypeptide binding]; other site 911045004545 KMSKS motif; other site 911045004546 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045004547 RNA binding surface [nucleotide binding]; other site 911045004548 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 911045004549 active site 911045004550 catalytic motif [active] 911045004551 Zn binding site [ion binding]; other site 911045004552 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 911045004553 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 911045004554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045004555 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 911045004556 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 911045004557 putative active site [active] 911045004558 catalytic site [active] 911045004559 putative metal binding site [ion binding]; other site 911045004560 AMP nucleosidase; Provisional; Region: PRK08292 911045004561 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 911045004562 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 911045004563 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 911045004564 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 911045004565 minor groove reading motif; other site 911045004566 helix-hairpin-helix signature motif; other site 911045004567 substrate binding pocket [chemical binding]; other site 911045004568 active site 911045004569 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 911045004570 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 911045004571 DNA binding and oxoG recognition site [nucleotide binding] 911045004572 Protein of unknown function (DUF721); Region: DUF721; cl02324 911045004573 Protease inhibitor Inh; Region: Inh; pfam02974 911045004574 Thioredoxin; Region: Thioredoxin_4; pfam13462 911045004575 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 911045004576 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 911045004577 AAA domain; Region: AAA_23; pfam13476 911045004578 Walker A/P-loop; other site 911045004579 ATP binding site [chemical binding]; other site 911045004580 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 911045004581 ABC transporter signature motif; other site 911045004582 Walker B; other site 911045004583 D-loop; other site 911045004584 H-loop/switch region; other site 911045004585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 911045004586 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 911045004587 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 911045004588 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 911045004589 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 911045004590 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 911045004591 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 911045004592 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 911045004593 Predicted transcriptional regulator [Transcription]; Region: COG2378 911045004594 HTH domain; Region: HTH_11; pfam08279 911045004595 WYL domain; Region: WYL; pfam13280 911045004596 oxidoreductase; Validated; Region: PRK05717 911045004597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004598 NAD(P) binding site [chemical binding]; other site 911045004599 active site 911045004600 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 911045004601 RNA/DNA hybrid binding site [nucleotide binding]; other site 911045004602 active site 911045004603 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 911045004604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045004605 FeS/SAM binding site; other site 911045004606 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045004607 active site 911045004608 malic enzyme; Reviewed; Region: PRK12862 911045004609 Malic enzyme, N-terminal domain; Region: malic; pfam00390 911045004610 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 911045004611 putative NAD(P) binding site [chemical binding]; other site 911045004612 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 911045004613 Protein of unknown function (DUF962); Region: DUF962; cl01879 911045004614 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045004615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045004616 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045004617 dimerization interface [polypeptide binding]; other site 911045004618 substrate binding pocket [chemical binding]; other site 911045004619 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 911045004620 DALR anticodon binding domain; Region: DALR_1; pfam05746 911045004621 Probable beta-xylosidase; Provisional; Region: PLN03080 911045004622 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 911045004623 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 911045004624 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 911045004625 dimer interface [polypeptide binding]; other site 911045004626 motif 1; other site 911045004627 active site 911045004628 motif 2; other site 911045004629 motif 3; other site 911045004630 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 911045004631 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 911045004632 tandem repeat interface [polypeptide binding]; other site 911045004633 oligomer interface [polypeptide binding]; other site 911045004634 active site residues [active] 911045004635 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 911045004636 Fe-S cluster binding site [ion binding]; other site 911045004637 active site 911045004638 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 911045004639 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 911045004640 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 911045004641 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 911045004642 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 911045004643 dimerization interface [polypeptide binding]; other site 911045004644 active site 911045004645 L-aspartate oxidase; Provisional; Region: PRK07512 911045004646 L-aspartate oxidase; Provisional; Region: PRK06175 911045004647 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 911045004648 quinolinate synthetase; Provisional; Region: PRK09375 911045004649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045004650 putative substrate translocation pore; other site 911045004651 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045004652 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 911045004653 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 911045004654 NADP binding site [chemical binding]; other site 911045004655 dimer interface [polypeptide binding]; other site 911045004656 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 911045004657 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 911045004658 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 911045004659 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 911045004660 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 911045004661 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 911045004662 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 911045004663 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 911045004664 Methyltransferase domain; Region: Methyltransf_23; pfam13489 911045004665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045004666 S-adenosylmethionine binding site [chemical binding]; other site 911045004667 LysE type translocator; Region: LysE; cl00565 911045004668 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 911045004669 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 911045004670 nudix motif; other site 911045004671 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 911045004672 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 911045004673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045004674 NAD(P) binding site [chemical binding]; other site 911045004675 active site 911045004676 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 911045004677 FAD binding domain; Region: FAD_binding_4; pfam01565 911045004678 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 911045004679 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 911045004680 NAD binding site [chemical binding]; other site 911045004681 homotetramer interface [polypeptide binding]; other site 911045004682 homodimer interface [polypeptide binding]; other site 911045004683 substrate binding site [chemical binding]; other site 911045004684 active site 911045004685 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045004686 catalytic core [active] 911045004687 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 911045004688 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 911045004689 Tetramer interface [polypeptide binding]; other site 911045004690 active site 911045004691 FMN-binding site [chemical binding]; other site 911045004692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045004693 non-specific DNA binding site [nucleotide binding]; other site 911045004694 salt bridge; other site 911045004695 sequence-specific DNA binding site [nucleotide binding]; other site 911045004696 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 911045004697 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 911045004698 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 911045004699 dimerization interface [polypeptide binding]; other site 911045004700 active site 911045004701 Methyltransferase domain; Region: Methyltransf_31; pfam13847 911045004702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045004703 S-adenosylmethionine binding site [chemical binding]; other site 911045004704 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045004705 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 911045004706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 911045004707 S-adenosylmethionine binding site [chemical binding]; other site 911045004708 Cache domain; Region: Cache_1; pfam02743 911045004709 HAMP domain; Region: HAMP; pfam00672 911045004710 dimerization interface [polypeptide binding]; other site 911045004711 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045004712 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045004713 dimer interface [polypeptide binding]; other site 911045004714 putative CheW interface [polypeptide binding]; other site 911045004715 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 911045004716 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045004717 RNA binding surface [nucleotide binding]; other site 911045004718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045004719 S-adenosylmethionine binding site [chemical binding]; other site 911045004720 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 911045004721 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 911045004722 Cu(I) binding site [ion binding]; other site 911045004723 Protein of unknown function (DUF461); Region: DUF461; pfam04314 911045004724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045004725 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045004726 putative substrate translocation pore; other site 911045004727 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 911045004728 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 911045004729 TPP-binding site; other site 911045004730 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 911045004731 PYR/PP interface [polypeptide binding]; other site 911045004732 dimer interface [polypeptide binding]; other site 911045004733 TPP binding site [chemical binding]; other site 911045004734 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 911045004735 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 911045004736 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 911045004737 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 911045004738 putative active site [active] 911045004739 Zn binding site [ion binding]; other site 911045004740 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 911045004741 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 911045004742 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045004743 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045004744 active site 911045004745 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 911045004746 enoyl-CoA hydratase; Provisional; Region: PRK06688 911045004747 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045004748 substrate binding site [chemical binding]; other site 911045004749 oxyanion hole (OAH) forming residues; other site 911045004750 trimer interface [polypeptide binding]; other site 911045004751 short chain dehydrogenase; Provisional; Region: PRK08278 911045004752 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 911045004753 NAD(P) binding site [chemical binding]; other site 911045004754 homodimer interface [polypeptide binding]; other site 911045004755 active site 911045004756 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 911045004757 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045004758 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045004759 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 911045004760 HSP70 interaction site [polypeptide binding]; other site 911045004761 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 911045004762 substrate binding site [polypeptide binding]; other site 911045004763 dimer interface [polypeptide binding]; other site 911045004764 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 911045004765 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 911045004766 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 911045004767 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 911045004768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045004769 motif II; other site 911045004770 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 911045004771 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 911045004772 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045004773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045004774 homodimer interface [polypeptide binding]; other site 911045004775 catalytic residue [active] 911045004776 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045004777 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 911045004778 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 911045004779 intersubunit interface [polypeptide binding]; other site 911045004780 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 911045004781 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 911045004782 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 911045004783 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045004784 ABC-ATPase subunit interface; other site 911045004785 dimer interface [polypeptide binding]; other site 911045004786 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 911045004787 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045004788 ABC-ATPase subunit interface; other site 911045004789 dimer interface [polypeptide binding]; other site 911045004790 putative PBP binding regions; other site 911045004791 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045004792 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 911045004793 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045004794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045004795 Walker A/P-loop; other site 911045004796 ATP binding site [chemical binding]; other site 911045004797 Q-loop/lid; other site 911045004798 ABC transporter signature motif; other site 911045004799 Walker B; other site 911045004800 D-loop; other site 911045004801 H-loop/switch region; other site 911045004802 TOBE domain; Region: TOBE_2; pfam08402 911045004803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045004804 dimer interface [polypeptide binding]; other site 911045004805 conserved gate region; other site 911045004806 putative PBP binding loops; other site 911045004807 ABC-ATPase subunit interface; other site 911045004808 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045004809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045004810 dimer interface [polypeptide binding]; other site 911045004811 conserved gate region; other site 911045004812 putative PBP binding loops; other site 911045004813 ABC-ATPase subunit interface; other site 911045004814 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 911045004815 putative hydrophobic ligand binding site [chemical binding]; other site 911045004816 CLM binding site; other site 911045004817 L1 loop; other site 911045004818 DNA binding site [nucleotide binding] 911045004819 TPR repeat; Region: TPR_11; pfam13414 911045004820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045004821 binding surface 911045004822 TPR motif; other site 911045004823 Tetratricopeptide repeat; Region: TPR_16; pfam13432 911045004824 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 911045004825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045004826 dimer interface [polypeptide binding]; other site 911045004827 phosphorylation site [posttranslational modification] 911045004828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045004829 ATP binding site [chemical binding]; other site 911045004830 Mg2+ binding site [ion binding]; other site 911045004831 G-X-G motif; other site 911045004832 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 911045004833 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 911045004834 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 911045004835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045004836 dimer interface [polypeptide binding]; other site 911045004837 conserved gate region; other site 911045004838 putative PBP binding loops; other site 911045004839 ABC-ATPase subunit interface; other site 911045004840 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 911045004841 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 911045004842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045004843 dimer interface [polypeptide binding]; other site 911045004844 conserved gate region; other site 911045004845 putative PBP binding loops; other site 911045004846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045004847 ABC-ATPase subunit interface; other site 911045004848 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 911045004849 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 911045004850 Walker A/P-loop; other site 911045004851 ATP binding site [chemical binding]; other site 911045004852 Q-loop/lid; other site 911045004853 ABC transporter signature motif; other site 911045004854 Walker B; other site 911045004855 D-loop; other site 911045004856 H-loop/switch region; other site 911045004857 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 911045004858 PhoU domain; Region: PhoU; pfam01895 911045004859 PhoU domain; Region: PhoU; pfam01895 911045004860 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 911045004861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045004862 active site 911045004863 phosphorylation site [posttranslational modification] 911045004864 intermolecular recognition site; other site 911045004865 dimerization interface [polypeptide binding]; other site 911045004866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045004867 DNA binding site [nucleotide binding] 911045004868 Predicted acetyltransferase [General function prediction only]; Region: COG5628 911045004869 GcrA cell cycle regulator; Region: GcrA; cl11564 911045004870 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 911045004871 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045004872 inhibitor-cofactor binding pocket; inhibition site 911045004873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045004874 catalytic residue [active] 911045004875 ornithine carbamoyltransferase; Provisional; Region: PRK00779 911045004876 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 911045004877 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 911045004878 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 911045004879 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 911045004880 dimerization interface [polypeptide binding]; other site 911045004881 domain crossover interface; other site 911045004882 redox-dependent activation switch; other site 911045004883 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 911045004884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 911045004885 Zn2+ binding site [ion binding]; other site 911045004886 Mg2+ binding site [ion binding]; other site 911045004887 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 911045004888 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 911045004889 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 911045004890 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 911045004891 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045004892 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045004893 substrate binding pocket [chemical binding]; other site 911045004894 membrane-bound complex binding site; other site 911045004895 hinge residues; other site 911045004896 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 911045004897 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045004898 DXD motif; other site 911045004899 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 911045004900 Ion transport protein; Region: Ion_trans; pfam00520 911045004901 Ion transport protein; Region: Ion_trans; pfam00520 911045004902 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 911045004903 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 911045004904 tellurite resistance protein terB; Region: terB; cd07176 911045004905 putative metal binding site [ion binding]; other site 911045004906 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 911045004907 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045004908 active site 911045004909 nucleotide binding site [chemical binding]; other site 911045004910 HIGH motif; other site 911045004911 KMSKS motif; other site 911045004912 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 911045004913 Staphylococcal nuclease homologues; Region: SNc; smart00318 911045004914 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 911045004915 Catalytic site; other site 911045004916 Predicted transcriptional regulator [Transcription]; Region: COG2932 911045004917 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 911045004918 Catalytic site [active] 911045004919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 911045004920 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 911045004921 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 911045004922 quinone interaction residues [chemical binding]; other site 911045004923 active site 911045004924 catalytic residues [active] 911045004925 FMN binding site [chemical binding]; other site 911045004926 substrate binding site [chemical binding]; other site 911045004927 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 911045004928 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 911045004929 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 911045004930 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 911045004931 putative active site [active] 911045004932 Zn binding site [ion binding]; other site 911045004933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045004934 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 911045004935 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 911045004936 putative NAD(P) binding site [chemical binding]; other site 911045004937 substrate binding site [chemical binding]; other site 911045004938 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045004939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045004940 Coenzyme A binding pocket [chemical binding]; other site 911045004941 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045004942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045004943 Coenzyme A binding pocket [chemical binding]; other site 911045004944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045004945 Coenzyme A binding pocket [chemical binding]; other site 911045004946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045004947 Coenzyme A binding pocket [chemical binding]; other site 911045004948 Predicted permeases [General function prediction only]; Region: COG0679 911045004949 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 911045004950 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045004951 substrate binding site [chemical binding]; other site 911045004952 oxyanion hole (OAH) forming residues; other site 911045004953 trimer interface [polypeptide binding]; other site 911045004954 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 911045004955 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045004956 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 911045004957 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 911045004958 dimer interface [polypeptide binding]; other site 911045004959 active site 911045004960 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 911045004961 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045004962 putative C-terminal domain interface [polypeptide binding]; other site 911045004963 putative GSH binding site (G-site) [chemical binding]; other site 911045004964 putative dimer interface [polypeptide binding]; other site 911045004965 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 911045004966 N-terminal domain interface [polypeptide binding]; other site 911045004967 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 911045004968 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 911045004969 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 911045004970 FAD binding site [chemical binding]; other site 911045004971 substrate binding site [chemical binding]; other site 911045004972 catalytic residues [active] 911045004973 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 911045004974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045004975 dimerization interface [polypeptide binding]; other site 911045004976 putative DNA binding site [nucleotide binding]; other site 911045004977 putative Zn2+ binding site [ion binding]; other site 911045004978 NIPSNAP; Region: NIPSNAP; pfam07978 911045004979 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 911045004980 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 911045004981 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 911045004982 DNA binding residues [nucleotide binding] 911045004983 putative dimer interface [polypeptide binding]; other site 911045004984 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045004985 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045004986 Sel1-like repeats; Region: SEL1; smart00671 911045004987 Sel1-like repeats; Region: SEL1; smart00671 911045004988 Sel1-like repeats; Region: SEL1; smart00671 911045004989 Sel1-like repeats; Region: SEL1; smart00671 911045004990 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 911045004991 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 911045004992 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045004993 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 911045004994 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 911045004995 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 911045004996 putative active site [active] 911045004997 putative metal binding site [ion binding]; other site 911045004998 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 911045004999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045005000 ATP binding site [chemical binding]; other site 911045005001 putative Mg++ binding site [ion binding]; other site 911045005002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045005003 nucleotide binding region [chemical binding]; other site 911045005004 ATP-binding site [chemical binding]; other site 911045005005 DEAD/H associated; Region: DEAD_assoc; pfam08494 911045005006 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 911045005007 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 911045005008 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 911045005009 putative catalytic residue [active] 911045005010 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 911045005011 active site 2 [active] 911045005012 active site 1 [active] 911045005013 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 911045005014 active site 1 [active] 911045005015 active site 2 [active] 911045005016 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 911045005017 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 911045005018 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 911045005019 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 911045005020 Na binding site [ion binding]; other site 911045005021 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045005022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005023 active site 911045005024 phosphorylation site [posttranslational modification] 911045005025 intermolecular recognition site; other site 911045005026 dimerization interface [polypeptide binding]; other site 911045005027 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045005028 DNA binding residues [nucleotide binding] 911045005029 dimerization interface [polypeptide binding]; other site 911045005030 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 911045005031 Na binding site [ion binding]; other site 911045005032 PAS fold; Region: PAS_7; pfam12860 911045005033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045005034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045005035 dimer interface [polypeptide binding]; other site 911045005036 phosphorylation site [posttranslational modification] 911045005037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045005038 ATP binding site [chemical binding]; other site 911045005039 Mg2+ binding site [ion binding]; other site 911045005040 G-X-G motif; other site 911045005041 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 911045005042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005043 active site 911045005044 phosphorylation site [posttranslational modification] 911045005045 intermolecular recognition site; other site 911045005046 dimerization interface [polypeptide binding]; other site 911045005047 PAS domain S-box; Region: sensory_box; TIGR00229 911045005048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045005049 putative active site [active] 911045005050 heme pocket [chemical binding]; other site 911045005051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045005052 dimer interface [polypeptide binding]; other site 911045005053 phosphorylation site [posttranslational modification] 911045005054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045005055 ATP binding site [chemical binding]; other site 911045005056 Mg2+ binding site [ion binding]; other site 911045005057 G-X-G motif; other site 911045005058 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 911045005059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005060 active site 911045005061 phosphorylation site [posttranslational modification] 911045005062 intermolecular recognition site; other site 911045005063 dimerization interface [polypeptide binding]; other site 911045005064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045005065 DNA binding residues [nucleotide binding] 911045005066 dimerization interface [polypeptide binding]; other site 911045005067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005068 active site 911045005069 phosphorylation site [posttranslational modification] 911045005070 intermolecular recognition site; other site 911045005071 dimerization interface [polypeptide binding]; other site 911045005072 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045005073 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 911045005074 ligand binding site [chemical binding]; other site 911045005075 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 911045005076 putative switch regulator; other site 911045005077 non-specific DNA interactions [nucleotide binding]; other site 911045005078 DNA binding site [nucleotide binding] 911045005079 sequence specific DNA binding site [nucleotide binding]; other site 911045005080 putative cAMP binding site [chemical binding]; other site 911045005081 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 911045005082 HemN C-terminal domain; Region: HemN_C; pfam06969 911045005083 Putative ammonia monooxygenase; Region: AmoA; pfam05145 911045005084 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 911045005085 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 911045005086 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 911045005087 Low-spin heme binding site [chemical binding]; other site 911045005088 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 911045005089 Putative water exit pathway; other site 911045005090 Binuclear center (active site) [active] 911045005091 Putative proton exit pathway; other site 911045005092 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 911045005093 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 911045005094 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 911045005095 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 911045005096 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 911045005097 Cytochrome c; Region: Cytochrom_C; pfam00034 911045005098 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 911045005099 4Fe-4S binding domain; Region: Fer4_5; pfam12801 911045005100 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 911045005101 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 911045005102 FixH; Region: FixH; pfam05751 911045005103 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 911045005104 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 911045005105 metal-binding site [ion binding] 911045005106 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045005107 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 911045005108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045005109 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 911045005110 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 911045005111 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 911045005112 substrate-cofactor binding pocket; other site 911045005113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045005114 catalytic residue [active] 911045005115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005116 Response regulator receiver domain; Region: Response_reg; pfam00072 911045005117 active site 911045005118 phosphorylation site [posttranslational modification] 911045005119 intermolecular recognition site; other site 911045005120 dimerization interface [polypeptide binding]; other site 911045005121 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 911045005122 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 911045005123 hinge; other site 911045005124 active site 911045005125 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 911045005126 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 911045005127 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 911045005128 NAD binding site [chemical binding]; other site 911045005129 dimerization interface [polypeptide binding]; other site 911045005130 product binding site; other site 911045005131 substrate binding site [chemical binding]; other site 911045005132 zinc binding site [ion binding]; other site 911045005133 catalytic residues [active] 911045005134 hypothetical protein; Provisional; Region: PRK02853 911045005135 Low molecular weight phosphatase family; Region: LMWPc; cl00105 911045005136 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 911045005137 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 911045005138 rRNA binding site [nucleotide binding]; other site 911045005139 predicted 30S ribosome binding site; other site 911045005140 Maf-like protein; Region: Maf; pfam02545 911045005141 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 911045005142 active site 911045005143 dimer interface [polypeptide binding]; other site 911045005144 Domain of unknown function (DUF329); Region: DUF329; cl01144 911045005145 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 911045005146 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 911045005147 active site 911045005148 metal binding site [ion binding]; metal-binding site 911045005149 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 911045005150 PaaX-like protein; Region: PaaX; pfam07848 911045005151 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 911045005152 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 911045005153 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 911045005154 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 911045005155 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 911045005156 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 911045005157 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 911045005158 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 911045005159 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 911045005160 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 911045005161 FAD binding pocket [chemical binding]; other site 911045005162 FAD binding motif [chemical binding]; other site 911045005163 phosphate binding motif [ion binding]; other site 911045005164 beta-alpha-beta structure motif; other site 911045005165 NAD(p) ribose binding residues [chemical binding]; other site 911045005166 NAD binding pocket [chemical binding]; other site 911045005167 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 911045005168 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045005169 catalytic loop [active] 911045005170 iron binding site [ion binding]; other site 911045005171 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 911045005172 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 911045005173 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045005174 MarR family; Region: MarR_2; pfam12802 911045005175 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045005176 Sel1-like repeats; Region: SEL1; smart00671 911045005177 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045005178 active site 911045005179 ATP binding site [chemical binding]; other site 911045005180 substrate binding site [chemical binding]; other site 911045005181 activation loop (A-loop); other site 911045005182 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045005183 active site 911045005184 ATP binding site [chemical binding]; other site 911045005185 substrate binding site [chemical binding]; other site 911045005186 activation loop (A-loop); other site 911045005187 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045005188 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 911045005189 C-terminal domain interface [polypeptide binding]; other site 911045005190 GSH binding site (G-site) [chemical binding]; other site 911045005191 dimer interface [polypeptide binding]; other site 911045005192 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 911045005193 dimer interface [polypeptide binding]; other site 911045005194 substrate binding pocket (H-site) [chemical binding]; other site 911045005195 N-terminal domain interface [polypeptide binding]; other site 911045005196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045005198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045005199 dimerization interface [polypeptide binding]; other site 911045005200 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 911045005201 maltose O-acetyltransferase; Provisional; Region: PRK10092 911045005202 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 911045005203 active site 911045005204 substrate binding site [chemical binding]; other site 911045005205 trimer interface [polypeptide binding]; other site 911045005206 CoA binding site [chemical binding]; other site 911045005207 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 911045005208 NADH(P)-binding; Region: NAD_binding_10; pfam13460 911045005209 NAD binding site [chemical binding]; other site 911045005210 substrate binding site [chemical binding]; other site 911045005211 putative active site [active] 911045005212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045005214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045005216 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 911045005217 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 911045005218 active site 911045005219 AMP binding site [chemical binding]; other site 911045005220 homodimer interface [polypeptide binding]; other site 911045005221 acyl-activating enzyme (AAE) consensus motif; other site 911045005222 CoA binding site [chemical binding]; other site 911045005223 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 911045005224 CoenzymeA binding site [chemical binding]; other site 911045005225 subunit interaction site [polypeptide binding]; other site 911045005226 PHB binding site; other site 911045005227 enoyl-CoA hydratase; Provisional; Region: PRK08140 911045005228 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045005229 substrate binding site [chemical binding]; other site 911045005230 oxyanion hole (OAH) forming residues; other site 911045005231 trimer interface [polypeptide binding]; other site 911045005232 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 911045005233 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 911045005234 NAD(P) binding site [chemical binding]; other site 911045005235 catalytic residues [active] 911045005236 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045005237 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045005238 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 911045005239 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 911045005240 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 911045005241 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 911045005242 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045005243 PYR/PP interface [polypeptide binding]; other site 911045005244 dimer interface [polypeptide binding]; other site 911045005245 TPP binding site [chemical binding]; other site 911045005246 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 911045005247 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 911045005248 TPP-binding site; other site 911045005249 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045005250 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045005251 substrate binding site [chemical binding]; other site 911045005252 ATP binding site [chemical binding]; other site 911045005253 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 911045005254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 911045005255 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 911045005256 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 911045005257 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 911045005258 putative active site [active] 911045005259 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 911045005260 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 911045005261 putative ligand binding site [chemical binding]; other site 911045005262 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 911045005263 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045005264 TM-ABC transporter signature motif; other site 911045005265 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 911045005266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045005267 Walker A/P-loop; other site 911045005268 ATP binding site [chemical binding]; other site 911045005269 Q-loop/lid; other site 911045005270 ABC transporter signature motif; other site 911045005271 Walker B; other site 911045005272 D-loop; other site 911045005273 H-loop/switch region; other site 911045005274 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045005275 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045005276 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 911045005277 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 911045005278 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045005279 DNA binding residues [nucleotide binding] 911045005280 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045005281 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 911045005282 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 911045005283 Proline racemase; Region: Pro_racemase; pfam05544 911045005284 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 911045005285 Uncharacterized membrane protein [Function unknown]; Region: COG3949 911045005286 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045005287 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 911045005288 conserved cys residue [active] 911045005289 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 911045005290 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 911045005291 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 911045005292 homodimer interface [polypeptide binding]; other site 911045005293 NADP binding site [chemical binding]; other site 911045005294 substrate binding site [chemical binding]; other site 911045005295 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 911045005296 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 911045005297 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 911045005298 putative active site [active] 911045005299 putative substrate binding site [chemical binding]; other site 911045005300 putative cosubstrate binding site; other site 911045005301 catalytic site [active] 911045005302 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045005303 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045005304 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 911045005305 active site 911045005306 DctM-like transporters; Region: DctM; pfam06808 911045005307 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045005308 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045005309 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045005310 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045005311 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 911045005312 FCD domain; Region: FCD; pfam07729 911045005313 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045005314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045005315 DNA-binding site [nucleotide binding]; DNA binding site 911045005316 FCD domain; Region: FCD; cl11656 911045005317 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045005318 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045005319 tetramer interface [polypeptide binding]; other site 911045005320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045005321 catalytic residue [active] 911045005322 putative L-aspartate dehydrogenase; Provisional; Region: PRK13302 911045005323 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 911045005324 Domain of unknown function DUF108; Region: DUF108; pfam01958 911045005325 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045005326 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045005327 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 911045005328 active site 911045005329 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 911045005330 Amidase; Region: Amidase; pfam01425 911045005331 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 911045005332 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045005333 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 911045005334 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 911045005335 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 911045005336 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 911045005337 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 911045005338 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045005339 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 911045005340 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 911045005341 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 911045005342 putative DNA binding site [nucleotide binding]; other site 911045005343 putative Zn2+ binding site [ion binding]; other site 911045005344 AsnC family; Region: AsnC_trans_reg; pfam01037 911045005345 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 911045005346 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 911045005347 metal binding site [ion binding]; metal-binding site 911045005348 putative dimer interface [polypeptide binding]; other site 911045005349 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 911045005350 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 911045005351 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045005352 catalytic residue [active] 911045005353 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 911045005354 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 911045005355 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 911045005356 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 911045005357 Protein of unknown function (DUF770); Region: DUF770; pfam05591 911045005358 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 911045005359 Protein of unknown function (DUF877); Region: DUF877; pfam05943 911045005360 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 911045005361 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 911045005362 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 911045005363 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 911045005364 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 911045005365 FHA domain; Region: FHA; pfam00498 911045005366 phosphopeptide binding site; other site 911045005367 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 911045005368 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 911045005369 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 911045005370 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 911045005371 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 911045005372 Clp amino terminal domain; Region: Clp_N; pfam02861 911045005373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045005374 Walker A motif; other site 911045005375 ATP binding site [chemical binding]; other site 911045005376 Walker B motif; other site 911045005377 arginine finger; other site 911045005378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045005379 Walker A motif; other site 911045005380 ATP binding site [chemical binding]; other site 911045005381 Walker B motif; other site 911045005382 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 911045005383 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 911045005384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045005385 Walker A motif; other site 911045005386 ATP binding site [chemical binding]; other site 911045005387 Walker B motif; other site 911045005388 arginine finger; other site 911045005389 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 911045005390 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 911045005391 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 911045005392 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 911045005393 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 911045005394 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 911045005395 active site turn [active] 911045005396 phosphorylation site [posttranslational modification] 911045005397 phosphotransferase system, EIIB; Region: PTS_EIIB; pfam00367 911045005398 active site turn [active] 911045005399 phosphorylation site [posttranslational modification] 911045005400 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 911045005401 HPr interaction site; other site 911045005402 glycerol kinase (GK) interaction site [polypeptide binding]; other site 911045005403 active site 911045005404 phosphorylation site [posttranslational modification] 911045005405 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 911045005406 dimerization domain swap beta strand [polypeptide binding]; other site 911045005407 regulatory protein interface [polypeptide binding]; other site 911045005408 active site 911045005409 regulatory phosphorylation site [posttranslational modification]; other site 911045005410 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 911045005411 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 911045005412 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 911045005413 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 911045005414 putative oxidoreductase; Provisional; Region: PRK11579 911045005415 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045005416 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 911045005417 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045005418 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 911045005419 substrate binding site [chemical binding]; other site 911045005420 ATP binding site [chemical binding]; other site 911045005421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045005422 ATP binding site [chemical binding]; other site 911045005423 Mg2+ binding site [ion binding]; other site 911045005424 G-X-G motif; other site 911045005425 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045005426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005427 active site 911045005428 phosphorylation site [posttranslational modification] 911045005429 intermolecular recognition site; other site 911045005430 dimerization interface [polypeptide binding]; other site 911045005431 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045005432 DNA binding site [nucleotide binding] 911045005433 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045005434 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045005435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005436 dimer interface [polypeptide binding]; other site 911045005437 conserved gate region; other site 911045005438 putative PBP binding loops; other site 911045005439 ABC-ATPase subunit interface; other site 911045005440 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045005441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005442 dimer interface [polypeptide binding]; other site 911045005443 conserved gate region; other site 911045005444 putative PBP binding loops; other site 911045005445 ABC-ATPase subunit interface; other site 911045005446 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 911045005447 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045005448 Walker A/P-loop; other site 911045005449 ATP binding site [chemical binding]; other site 911045005450 Q-loop/lid; other site 911045005451 ABC transporter signature motif; other site 911045005452 Walker B; other site 911045005453 D-loop; other site 911045005454 H-loop/switch region; other site 911045005455 TOBE domain; Region: TOBE; pfam03459 911045005456 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 911045005457 Autotransporter beta-domain; Region: Autotransporter; pfam03797 911045005458 Transcriptional regulator; Region: Rrf2; cl17282 911045005459 Predicted transcriptional regulator [Transcription]; Region: COG1959 911045005460 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045005461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045005462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045005463 putative substrate translocation pore; other site 911045005464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045005466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045005467 dimerization interface [polypeptide binding]; other site 911045005468 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045005469 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 911045005470 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045005471 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 911045005472 DctM-like transporters; Region: DctM; pfam06808 911045005473 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045005474 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045005475 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045005476 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045005477 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 911045005478 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 911045005479 active site pocket [active] 911045005480 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 911045005481 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 911045005482 inhibitor site; inhibition site 911045005483 active site 911045005484 dimer interface [polypeptide binding]; other site 911045005485 catalytic residue [active] 911045005486 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 911045005487 classical (c) SDRs; Region: SDR_c; cd05233 911045005488 NAD(P) binding site [chemical binding]; other site 911045005489 active site 911045005490 Domain of unknown function (DUF386); Region: DUF386; cl01047 911045005491 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 911045005492 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 911045005493 active site 911045005494 intersubunit interface [polypeptide binding]; other site 911045005495 catalytic residue [active] 911045005496 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 911045005497 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 911045005498 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045005499 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 911045005500 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 911045005501 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 911045005502 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 911045005503 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 911045005504 heme binding site [chemical binding]; other site 911045005505 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 911045005506 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 911045005507 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 911045005508 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 911045005509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005510 dimer interface [polypeptide binding]; other site 911045005511 conserved gate region; other site 911045005512 putative PBP binding loops; other site 911045005513 ABC-ATPase subunit interface; other site 911045005514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045005515 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 911045005516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045005517 Walker A/P-loop; other site 911045005518 ATP binding site [chemical binding]; other site 911045005519 Q-loop/lid; other site 911045005520 ABC transporter signature motif; other site 911045005521 Walker B; other site 911045005522 D-loop; other site 911045005523 H-loop/switch region; other site 911045005524 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 911045005525 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 911045005526 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 911045005527 putative dimer interface [polypeptide binding]; other site 911045005528 N-terminal domain interface [polypeptide binding]; other site 911045005529 putative substrate binding pocket (H-site) [chemical binding]; other site 911045005530 Uncharacterized conserved protein [Function unknown]; Region: COG5470 911045005531 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045005532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045005533 DNA-binding site [nucleotide binding]; DNA binding site 911045005534 FCD domain; Region: FCD; pfam07729 911045005535 Amino acid synthesis; Region: AA_synth; pfam06684 911045005536 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045005537 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 911045005538 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 911045005539 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 911045005540 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 911045005541 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045005542 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 911045005543 NAD(P) binding site [chemical binding]; other site 911045005544 catalytic residues [active] 911045005545 BCCT family transporter; Region: BCCT; pfam02028 911045005546 succinic semialdehyde dehydrogenase; Region: PLN02278 911045005547 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 911045005548 tetramerization interface [polypeptide binding]; other site 911045005549 NAD(P) binding site [chemical binding]; other site 911045005550 catalytic residues [active] 911045005551 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045005552 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045005553 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045005554 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 911045005555 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 911045005556 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 911045005557 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 911045005558 metal-binding site [ion binding] 911045005559 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 911045005560 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 911045005561 metal-binding site [ion binding] 911045005562 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045005563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045005564 motif II; other site 911045005565 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 911045005566 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 911045005567 DNA binding residues [nucleotide binding] 911045005568 dimer interface [polypeptide binding]; other site 911045005569 copper binding site [ion binding]; other site 911045005570 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 911045005571 putative catalytic residue [active] 911045005572 DctM-like transporters; Region: DctM; pfam06808 911045005573 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045005574 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045005575 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045005576 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 911045005577 AAA domain; Region: AAA_33; pfam13671 911045005578 ATP-binding site [chemical binding]; other site 911045005579 Gluconate-6-phosphate binding site [chemical binding]; other site 911045005580 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045005581 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045005582 DNA binding site [nucleotide binding] 911045005583 domain linker motif; other site 911045005584 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 911045005585 putative ligand binding site [chemical binding]; other site 911045005586 putative dimerization interface [polypeptide binding]; other site 911045005587 D-lactate dehydrogenase; Provisional; Region: PRK11183 911045005588 FAD binding domain; Region: FAD_binding_4; pfam01565 911045005589 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 911045005590 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045005591 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 911045005592 DctM-like transporters; Region: DctM; pfam06808 911045005593 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045005594 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045005595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045005596 DNA-binding site [nucleotide binding]; DNA binding site 911045005597 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 911045005598 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 911045005599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045005600 hypothetical protein; Validated; Region: PRK08223 911045005601 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 911045005602 ATP binding site [chemical binding]; other site 911045005603 substrate interface [chemical binding]; other site 911045005604 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 911045005605 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 911045005606 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 911045005607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005608 dimer interface [polypeptide binding]; other site 911045005609 conserved gate region; other site 911045005610 putative PBP binding loops; other site 911045005611 ABC-ATPase subunit interface; other site 911045005612 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 911045005613 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 911045005614 Walker A/P-loop; other site 911045005615 ATP binding site [chemical binding]; other site 911045005616 Q-loop/lid; other site 911045005617 ABC transporter signature motif; other site 911045005618 Walker B; other site 911045005619 D-loop; other site 911045005620 H-loop/switch region; other site 911045005621 NnrS protein; Region: NnrS; pfam05940 911045005622 HAMP domain; Region: HAMP; pfam00672 911045005623 PAS fold; Region: PAS_7; pfam12860 911045005624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 911045005625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045005626 dimer interface [polypeptide binding]; other site 911045005627 phosphorylation site [posttranslational modification] 911045005628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045005629 ATP binding site [chemical binding]; other site 911045005630 Mg2+ binding site [ion binding]; other site 911045005631 G-X-G motif; other site 911045005632 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 911045005633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005634 active site 911045005635 phosphorylation site [posttranslational modification] 911045005636 intermolecular recognition site; other site 911045005637 dimerization interface [polypeptide binding]; other site 911045005638 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045005639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045005640 active site 911045005641 phosphorylation site [posttranslational modification] 911045005642 intermolecular recognition site; other site 911045005643 dimerization interface [polypeptide binding]; other site 911045005644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045005645 DNA binding site [nucleotide binding] 911045005646 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 911045005647 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045005648 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 911045005649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005650 dimer interface [polypeptide binding]; other site 911045005651 conserved gate region; other site 911045005652 putative PBP binding loops; other site 911045005653 ABC-ATPase subunit interface; other site 911045005654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005655 dimer interface [polypeptide binding]; other site 911045005656 conserved gate region; other site 911045005657 putative PBP binding loops; other site 911045005658 ABC-ATPase subunit interface; other site 911045005659 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045005660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045005661 Walker A/P-loop; other site 911045005662 ATP binding site [chemical binding]; other site 911045005663 Q-loop/lid; other site 911045005664 ABC transporter signature motif; other site 911045005665 Walker B; other site 911045005666 D-loop; other site 911045005667 H-loop/switch region; other site 911045005668 TOBE domain; Region: TOBE_2; pfam08402 911045005669 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 911045005670 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 911045005671 Cytochrome C' Region: Cytochrom_C_2; pfam01322 911045005672 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 911045005673 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 911045005674 Walker A/P-loop; other site 911045005675 ATP binding site [chemical binding]; other site 911045005676 Q-loop/lid; other site 911045005677 ABC transporter signature motif; other site 911045005678 Walker B; other site 911045005679 D-loop; other site 911045005680 H-loop/switch region; other site 911045005681 DevC protein; Region: devC; TIGR01185 911045005682 FtsX-like permease family; Region: FtsX; pfam02687 911045005683 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 911045005684 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045005685 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 911045005686 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045005687 dimer interface [polypeptide binding]; other site 911045005688 putative CheW interface [polypeptide binding]; other site 911045005689 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 911045005690 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 911045005691 Autotransporter beta-domain; Region: Autotransporter; pfam03797 911045005692 TIGR03032 family protein; Region: TIGR03032 911045005693 Dehydratase family; Region: ILVD_EDD; cl00340 911045005694 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045005695 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 911045005696 tetramerization interface [polypeptide binding]; other site 911045005697 NAD(P) binding site [chemical binding]; other site 911045005698 catalytic residues [active] 911045005699 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 911045005700 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Region: TPP_enzyme_N; pfam02776 911045005701 PYR/PP interface [polypeptide binding]; other site 911045005702 dimer interface [polypeptide binding]; other site 911045005703 TPP binding site [chemical binding]; other site 911045005704 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 911045005705 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 911045005706 TPP-binding site [chemical binding]; other site 911045005707 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045005708 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045005709 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 911045005710 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045005711 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 911045005712 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045005713 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045005714 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045005715 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 911045005716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005717 dimer interface [polypeptide binding]; other site 911045005718 conserved gate region; other site 911045005719 putative PBP binding loops; other site 911045005720 ABC-ATPase subunit interface; other site 911045005721 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045005722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005723 dimer interface [polypeptide binding]; other site 911045005724 conserved gate region; other site 911045005725 putative PBP binding loops; other site 911045005726 ABC-ATPase subunit interface; other site 911045005727 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045005728 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045005729 Walker A/P-loop; other site 911045005730 ATP binding site [chemical binding]; other site 911045005731 Q-loop/lid; other site 911045005732 ABC transporter signature motif; other site 911045005733 Walker B; other site 911045005734 D-loop; other site 911045005735 H-loop/switch region; other site 911045005736 Uncharacterized conserved protein [Function unknown]; Region: COG1633 911045005737 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 911045005738 diiron binding motif [ion binding]; other site 911045005739 Uncharacterized conserved protein [Function unknown]; Region: COG1633 911045005740 CCC1-related protein family; Region: CCC1_like_1; cd02437 911045005741 Membrane transport protein; Region: Mem_trans; cl09117 911045005742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045005743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045005745 dimerization interface [polypeptide binding]; other site 911045005746 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 911045005747 amino acid carrier protein; Region: agcS; TIGR00835 911045005748 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 911045005749 active site 911045005750 catalytic site [active] 911045005751 substrate binding site [chemical binding]; other site 911045005752 RES domain; Region: RES; smart00953 911045005753 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 911045005754 Autotransporter beta-domain; Region: Autotransporter; pfam03797 911045005755 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 911045005756 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 911045005757 conserved cys residue [active] 911045005758 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 911045005759 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 911045005760 conserved cys residue [active] 911045005761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045005762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005763 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 911045005764 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 911045005765 potential catalytic triad [active] 911045005766 conserved cys residue [active] 911045005767 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 911045005768 Prostaglandin dehydrogenases; Region: PGDH; cd05288 911045005769 NAD(P) binding site [chemical binding]; other site 911045005770 substrate binding site [chemical binding]; other site 911045005771 dimer interface [polypeptide binding]; other site 911045005772 OsmC-like protein; Region: OsmC; cl00767 911045005773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045005775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045005777 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 911045005778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045005779 S-adenosylmethionine binding site [chemical binding]; other site 911045005780 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 911045005781 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 911045005782 SnoaL-like domain; Region: SnoaL_4; pfam13577 911045005783 SnoaL-like domain; Region: SnoaL_2; pfam12680 911045005784 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 911045005785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005786 NAD(P) binding site [chemical binding]; other site 911045005787 active site 911045005788 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 911045005789 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045005790 NAD binding site [chemical binding]; other site 911045005791 putative substrate binding site 2 [chemical binding]; other site 911045005792 putative substrate binding site 1 [chemical binding]; other site 911045005793 active site 911045005794 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 911045005795 benzoate transporter; Region: benE; TIGR00843 911045005796 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 911045005797 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045005798 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045005799 Walker A/P-loop; other site 911045005800 ATP binding site [chemical binding]; other site 911045005801 Q-loop/lid; other site 911045005802 ABC transporter signature motif; other site 911045005803 Walker B; other site 911045005804 D-loop; other site 911045005805 H-loop/switch region; other site 911045005806 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045005807 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045005808 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045005809 Walker A/P-loop; other site 911045005810 ATP binding site [chemical binding]; other site 911045005811 Q-loop/lid; other site 911045005812 ABC transporter signature motif; other site 911045005813 Walker B; other site 911045005814 D-loop; other site 911045005815 H-loop/switch region; other site 911045005816 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 911045005817 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 911045005818 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045005819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005820 dimer interface [polypeptide binding]; other site 911045005821 conserved gate region; other site 911045005822 putative PBP binding loops; other site 911045005823 ABC-ATPase subunit interface; other site 911045005824 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 911045005825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005826 dimer interface [polypeptide binding]; other site 911045005827 conserved gate region; other site 911045005828 putative PBP binding loops; other site 911045005829 ABC-ATPase subunit interface; other site 911045005830 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 911045005831 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 911045005832 peptide binding site [polypeptide binding]; other site 911045005833 hypothetical protein; Validated; Region: PRK08238 911045005834 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 911045005835 Predicted membrane protein [Function unknown]; Region: COG2246 911045005836 GtrA-like protein; Region: GtrA; pfam04138 911045005837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045005838 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 911045005839 putative substrate translocation pore; other site 911045005840 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 911045005841 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045005842 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045005843 dimer interface [polypeptide binding]; other site 911045005844 putative CheW interface [polypeptide binding]; other site 911045005845 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045005846 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 911045005847 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 911045005848 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 911045005849 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 911045005850 ABC transporter; Region: ABC_tran_2; pfam12848 911045005851 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 911045005852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045005853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045005854 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 911045005855 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 911045005856 [2Fe-2S] cluster binding site [ion binding]; other site 911045005857 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 911045005858 putative alpha subunit interface [polypeptide binding]; other site 911045005859 putative active site [active] 911045005860 putative substrate binding site [chemical binding]; other site 911045005861 Fe binding site [ion binding]; other site 911045005862 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045005863 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 911045005864 FAD binding pocket [chemical binding]; other site 911045005865 FAD binding motif [chemical binding]; other site 911045005866 phosphate binding motif [ion binding]; other site 911045005867 beta-alpha-beta structure motif; other site 911045005868 NAD binding pocket [chemical binding]; other site 911045005869 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045005870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045005871 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 911045005872 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 911045005873 Beta-lactamase; Region: Beta-lactamase; pfam00144 911045005874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045005876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045005877 dimerization interface [polypeptide binding]; other site 911045005878 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 911045005879 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045005880 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 911045005881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005882 NAD(P) binding site [chemical binding]; other site 911045005883 active site 911045005884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045005885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045005886 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045005887 putative effector binding pocket; other site 911045005888 dimerization interface [polypeptide binding]; other site 911045005889 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 911045005890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045005891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045005892 Coenzyme A binding pocket [chemical binding]; other site 911045005893 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045005894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045005895 DNA-binding site [nucleotide binding]; DNA binding site 911045005896 FCD domain; Region: FCD; pfam07729 911045005897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045005898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045005899 Coenzyme A binding pocket [chemical binding]; other site 911045005900 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 911045005901 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045005902 DNA binding residues [nucleotide binding] 911045005903 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045005904 P-loop; other site 911045005905 Magnesium ion binding site [ion binding]; other site 911045005906 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045005907 Magnesium ion binding site [ion binding]; other site 911045005908 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 911045005909 ParB-like nuclease domain; Region: ParBc; pfam02195 911045005910 replication initiation protein RepC; Provisional; Region: PRK13824 911045005911 Replication protein C N-terminal domain; Region: RP-C; pfam03428 911045005912 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 911045005913 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045005914 nudix motif; other site 911045005915 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045005916 nudix motif; other site 911045005917 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 911045005918 Sodium Bile acid symporter family; Region: SBF; cl17470 911045005919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045005920 putative DNA binding site [nucleotide binding]; other site 911045005921 putative Zn2+ binding site [ion binding]; other site 911045005922 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 911045005923 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045005924 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 911045005925 Short C-terminal domain; Region: SHOCT; pfam09851 911045005926 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 911045005927 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045005928 active site 911045005929 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045005930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045005931 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 911045005932 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 911045005933 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045005934 Soluble P-type ATPase [General function prediction only]; Region: COG4087 911045005935 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 911045005936 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 911045005937 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 911045005938 NAD(P) binding site [chemical binding]; other site 911045005939 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045005940 classical (c) SDRs; Region: SDR_c; cd05233 911045005941 NAD(P) binding site [chemical binding]; other site 911045005942 active site 911045005943 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 911045005944 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 911045005945 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 911045005946 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045005947 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 911045005948 active site 911045005949 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045005950 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045005951 active site 911045005952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005953 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045005954 NAD(P) binding site [chemical binding]; other site 911045005955 active site 911045005956 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 911045005957 putative active site [active] 911045005958 putative catalytic site [active] 911045005959 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045005960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045005961 NAD(P) binding site [chemical binding]; other site 911045005962 active site 911045005963 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 911045005964 putative active site [active] 911045005965 putative substrate binding site [chemical binding]; other site 911045005966 ATP binding site [chemical binding]; other site 911045005967 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 911045005968 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045005969 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045005970 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 911045005971 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045005972 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045005973 Walker A/P-loop; other site 911045005974 ATP binding site [chemical binding]; other site 911045005975 Q-loop/lid; other site 911045005976 ABC transporter signature motif; other site 911045005977 Walker B; other site 911045005978 D-loop; other site 911045005979 H-loop/switch region; other site 911045005980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045005981 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 911045005982 Walker A/P-loop; other site 911045005983 ATP binding site [chemical binding]; other site 911045005984 Q-loop/lid; other site 911045005985 ABC transporter signature motif; other site 911045005986 Walker B; other site 911045005987 D-loop; other site 911045005988 H-loop/switch region; other site 911045005989 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 911045005990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005991 dimer interface [polypeptide binding]; other site 911045005992 conserved gate region; other site 911045005993 ABC-ATPase subunit interface; other site 911045005994 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045005995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045005996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045005997 putative PBP binding loops; other site 911045005998 dimer interface [polypeptide binding]; other site 911045005999 ABC-ATPase subunit interface; other site 911045006000 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045006001 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045006002 SprA-related family; Region: SprA-related; pfam12118 911045006003 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045006004 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045006005 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 911045006006 DNA binding residues [nucleotide binding] 911045006007 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 911045006008 dimer interface [polypeptide binding]; other site 911045006009 putative metal binding site [ion binding]; other site 911045006010 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 911045006011 topology modulation protein; Reviewed; Region: PRK08118 911045006012 AAA domain; Region: AAA_17; pfam13207 911045006013 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045006014 homotrimer interaction site [polypeptide binding]; other site 911045006015 putative active site [active] 911045006016 Predicted transcriptional regulator [Transcription]; Region: COG2378 911045006017 HTH domain; Region: HTH_11; pfam08279 911045006018 WYL domain; Region: WYL; pfam13280 911045006019 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 911045006020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045006021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045006022 Predicted periplasmic protein [Function unknown]; Region: COG3904 911045006023 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 911045006024 putative active site [active] 911045006025 putative metal binding residues [ion binding]; other site 911045006026 signature motif; other site 911045006027 putative triphosphate binding site [ion binding]; other site 911045006028 dimer interface [polypeptide binding]; other site 911045006029 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 911045006030 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045006031 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045006032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045006033 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045006034 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 911045006035 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045006036 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045006037 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 911045006038 dimer interface [polypeptide binding]; other site 911045006039 N-terminal domain interface [polypeptide binding]; other site 911045006040 substrate binding pocket (H-site) [chemical binding]; other site 911045006041 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 911045006042 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 911045006043 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 911045006044 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045006045 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045006046 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045006047 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045006048 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 911045006049 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 911045006050 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 911045006051 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045006052 substrate binding site [chemical binding]; other site 911045006053 oxyanion hole (OAH) forming residues; other site 911045006054 trimer interface [polypeptide binding]; other site 911045006055 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045006056 active site 911045006057 ATP binding site [chemical binding]; other site 911045006058 substrate binding site [chemical binding]; other site 911045006059 activation loop (A-loop); other site 911045006060 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045006061 active site 911045006062 ATP binding site [chemical binding]; other site 911045006063 substrate binding site [chemical binding]; other site 911045006064 activation loop (A-loop); other site 911045006065 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045006066 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045006067 ligand binding site [chemical binding]; other site 911045006068 flexible hinge region; other site 911045006069 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 911045006070 putative switch regulator; other site 911045006071 non-specific DNA interactions [nucleotide binding]; other site 911045006072 DNA binding site [nucleotide binding] 911045006073 sequence specific DNA binding site [nucleotide binding]; other site 911045006074 putative cAMP binding site [chemical binding]; other site 911045006075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 911045006076 Methyltransferase domain; Region: Methyltransf_23; pfam13489 911045006077 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 911045006078 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 911045006079 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 911045006080 Putative phosphatase (DUF442); Region: DUF442; cl17385 911045006081 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 911045006082 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 911045006083 high affinity sulphate transporter 1; Region: sulP; TIGR00815 911045006084 Sulfate transporter family; Region: Sulfate_transp; pfam00916 911045006085 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 911045006086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045006087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045006088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045006089 ethanolamine permease; Region: 2A0305; TIGR00908 911045006090 Methyltransferase domain; Region: Methyltransf_31; pfam13847 911045006091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045006092 S-adenosylmethionine binding site [chemical binding]; other site 911045006093 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 911045006094 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 911045006095 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 911045006096 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 911045006097 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 911045006098 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 911045006099 [4Fe-4S] binding site [ion binding]; other site 911045006100 molybdopterin cofactor binding site; other site 911045006101 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 911045006102 molybdopterin cofactor binding site; other site 911045006103 NapD protein; Region: NapD; pfam03927 911045006104 ferredoxin-type protein; Provisional; Region: PRK10194 911045006105 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 911045006106 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 911045006107 4Fe-4S binding domain; Region: Fer4; cl02805 911045006108 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 911045006109 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045006110 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045006111 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045006112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045006113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045006114 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 911045006115 CoenzymeA binding site [chemical binding]; other site 911045006116 subunit interaction site [polypeptide binding]; other site 911045006117 PHB binding site; other site 911045006118 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 911045006119 YadA-like C-terminal region; Region: YadA; pfam03895 911045006120 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045006121 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 911045006122 substrate binding site [chemical binding]; other site 911045006123 ATP binding site [chemical binding]; other site 911045006124 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 911045006125 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 911045006126 active site 911045006127 intersubunit interface [polypeptide binding]; other site 911045006128 zinc binding site [ion binding]; other site 911045006129 Na+ binding site [ion binding]; other site 911045006130 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 911045006131 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 911045006132 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 911045006133 Sulfatase; Region: Sulfatase; cl17466 911045006134 choline-sulfatase; Region: chol_sulfatase; TIGR03417 911045006135 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 911045006136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045006137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045006138 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045006139 dimerization interface [polypeptide binding]; other site 911045006140 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 911045006141 active site 911045006142 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 911045006143 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045006144 active site 911045006145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045006146 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045006147 putative substrate translocation pore; other site 911045006148 EamA-like transporter family; Region: EamA; cl17759 911045006149 glycerate dehydrogenase; Provisional; Region: PRK06932 911045006150 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 911045006151 putative ligand binding site [chemical binding]; other site 911045006152 putative NAD binding site [chemical binding]; other site 911045006153 catalytic site [active] 911045006154 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045006155 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 911045006156 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045006157 catalytic core [active] 911045006158 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045006159 extended (e) SDRs; Region: SDR_e; cd08946 911045006160 active site 911045006161 substrate binding site [chemical binding]; other site 911045006162 Protein of unknown function, DUF606; Region: DUF606; pfam04657 911045006163 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 911045006164 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045006165 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045006166 ligand binding site [chemical binding]; other site 911045006167 flexible hinge region; other site 911045006168 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 911045006169 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045006170 AAA domain; Region: AAA_33; pfam13671 911045006171 AAA domain; Region: AAA_17; pfam13207 911045006172 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 911045006173 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045006174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045006175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045006176 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 911045006177 substrate binding pocket [chemical binding]; other site 911045006178 dimerization interface [polypeptide binding]; other site 911045006179 Cupin; Region: Cupin_6; pfam12852 911045006180 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045006181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045006182 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045006183 Protein of unknown function, DUF488; Region: DUF488; pfam04343 911045006184 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 911045006185 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045006186 N-terminal plug; other site 911045006187 ligand-binding site [chemical binding]; other site 911045006188 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 911045006189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045006190 Walker A/P-loop; other site 911045006191 ATP binding site [chemical binding]; other site 911045006192 Q-loop/lid; other site 911045006193 ABC transporter signature motif; other site 911045006194 Walker B; other site 911045006195 D-loop; other site 911045006196 H-loop/switch region; other site 911045006197 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 911045006198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045006199 putative substrate translocation pore; other site 911045006200 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045006201 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 911045006202 Predicted metal-binding protein [General function prediction only]; Region: COG3019 911045006203 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 911045006204 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045006205 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045006206 active site 911045006207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045006208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045006209 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045006210 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045006211 active site 911045006212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045006213 short chain dehydrogenase; Provisional; Region: PRK06500 911045006214 classical (c) SDRs; Region: SDR_c; cd05233 911045006215 NAD(P) binding site [chemical binding]; other site 911045006216 active site 911045006217 SnoaL-like domain; Region: SnoaL_3; pfam13474 911045006218 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 911045006219 putative catalytic residues [active] 911045006220 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045006221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045006222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045006223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045006224 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045006225 dimerization interface [polypeptide binding]; other site 911045006226 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 911045006227 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 911045006228 dimer interface [polypeptide binding]; other site 911045006229 PYR/PP interface [polypeptide binding]; other site 911045006230 TPP binding site [chemical binding]; other site 911045006231 substrate binding site [chemical binding]; other site 911045006232 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 911045006233 TPP-binding site [chemical binding]; other site 911045006234 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 911045006235 Cache domain; Region: Cache_1; pfam02743 911045006236 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045006237 dimerization interface [polypeptide binding]; other site 911045006238 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045006239 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045006240 dimer interface [polypeptide binding]; other site 911045006241 putative CheW interface [polypeptide binding]; other site 911045006242 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045006243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045006244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045006245 Protein of unknown function, DUF417; Region: DUF417; cl01162 911045006246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045006247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045006248 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 911045006249 Ligand Binding Site [chemical binding]; other site 911045006250 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 911045006251 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 911045006252 Phosphotransferase enzyme family; Region: APH; pfam01636 911045006253 putative active site [active] 911045006254 putative substrate binding site [chemical binding]; other site 911045006255 ATP binding site [chemical binding]; other site 911045006256 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 911045006257 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 911045006258 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 911045006259 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 911045006260 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 911045006261 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045006262 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 911045006263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045006264 dimer interface [polypeptide binding]; other site 911045006265 phosphorylation site [posttranslational modification] 911045006266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045006267 ATP binding site [chemical binding]; other site 911045006268 Mg2+ binding site [ion binding]; other site 911045006269 G-X-G motif; other site 911045006270 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 911045006271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045006272 active site 911045006273 phosphorylation site [posttranslational modification] 911045006274 intermolecular recognition site; other site 911045006275 dimerization interface [polypeptide binding]; other site 911045006276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045006277 DNA binding residues [nucleotide binding] 911045006278 dimerization interface [polypeptide binding]; other site 911045006279 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 911045006280 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 911045006281 P-loop motif; other site 911045006282 ATP binding site [chemical binding]; other site 911045006283 Chloramphenicol (Cm) binding site [chemical binding]; other site 911045006284 catalytic residue [active] 911045006285 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 911045006286 putative trimer interface [polypeptide binding]; other site 911045006287 putative CoA binding site [chemical binding]; other site 911045006288 Ceramidase; Region: Ceramidase; pfam05875 911045006289 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045006290 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 911045006291 4Fe-4S binding domain; Region: Fer4; pfam00037 911045006292 tetrathionate reductase subunit C; Provisional; Region: PRK14992 911045006293 tetrathionate reductase subunit A; Provisional; Region: PRK14991 911045006294 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 911045006295 molybdopterin cofactor binding site; other site 911045006296 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 911045006297 putative molybdopterin cofactor binding site [chemical binding]; other site 911045006298 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 911045006299 putative molybdopterin cofactor binding site; other site 911045006300 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 911045006301 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 911045006302 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 911045006303 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045006304 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 911045006305 active site 911045006306 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 911045006307 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 911045006308 active site 911045006309 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 911045006310 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045006311 dimer interface [polypeptide binding]; other site 911045006312 putative metal binding site [ion binding]; other site 911045006313 enoyl-CoA hydratase; Provisional; Region: PRK08140 911045006314 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045006315 substrate binding site [chemical binding]; other site 911045006316 oxyanion hole (OAH) forming residues; other site 911045006317 trimer interface [polypeptide binding]; other site 911045006318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045006319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045006320 LysR substrate binding domain; Region: LysR_substrate; pfam03466 911045006321 dimerization interface [polypeptide binding]; other site 911045006322 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 911045006323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 911045006324 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045006325 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045006326 substrate binding pocket [chemical binding]; other site 911045006327 membrane-bound complex binding site; other site 911045006328 hinge residues; other site 911045006329 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045006330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006331 dimer interface [polypeptide binding]; other site 911045006332 conserved gate region; other site 911045006333 putative PBP binding loops; other site 911045006334 ABC-ATPase subunit interface; other site 911045006335 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 911045006336 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 911045006337 Multicopper oxidase; Region: Cu-oxidase; pfam00394 911045006338 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 911045006339 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 911045006340 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 911045006341 active site 911045006342 SAM binding site [chemical binding]; other site 911045006343 homodimer interface [polypeptide binding]; other site 911045006344 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 911045006345 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045006346 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045006347 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045006348 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 911045006349 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 911045006350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045006351 FeS/SAM binding site; other site 911045006352 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 911045006353 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 911045006354 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 911045006355 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 911045006356 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 911045006357 structural tetrad; other site 911045006358 hypothetical protein; Provisional; Region: PRK02395 911045006359 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 911045006360 putative active site [active] 911045006361 peroxiredoxin; Provisional; Region: PRK13189 911045006362 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 911045006363 dimer interface [polypeptide binding]; other site 911045006364 decamer (pentamer of dimers) interface [polypeptide binding]; other site 911045006365 catalytic triad [active] 911045006366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045006367 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 911045006368 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 911045006369 dimerization interface [polypeptide binding]; other site 911045006370 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045006371 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045006372 ligand binding site [chemical binding]; other site 911045006373 flexible hinge region; other site 911045006374 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 911045006375 putative switch regulator; other site 911045006376 non-specific DNA interactions [nucleotide binding]; other site 911045006377 DNA binding site [nucleotide binding] 911045006378 sequence specific DNA binding site [nucleotide binding]; other site 911045006379 putative cAMP binding site [chemical binding]; other site 911045006380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045006381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045006382 Coenzyme A binding pocket [chemical binding]; other site 911045006383 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045006384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045006385 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 911045006386 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045006387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045006388 catalytic residue [active] 911045006389 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 911045006390 Ca2+ binding site [ion binding]; other site 911045006391 Calx-beta domain; Region: Calx-beta; cl02522 911045006392 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 911045006393 generic binding surface I; other site 911045006394 generic binding surface II; other site 911045006395 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045006396 putative catalytic site [active] 911045006397 putative metal binding site [ion binding]; other site 911045006398 putative phosphate binding site [ion binding]; other site 911045006399 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045006400 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045006401 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045006402 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 911045006403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045006404 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 911045006405 Walker A/P-loop; other site 911045006406 ATP binding site [chemical binding]; other site 911045006407 Q-loop/lid; other site 911045006408 ABC transporter signature motif; other site 911045006409 Walker B; other site 911045006410 D-loop; other site 911045006411 H-loop/switch region; other site 911045006412 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 911045006413 active site 911045006414 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045006415 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 911045006416 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 911045006417 active site pocket [active] 911045006418 BCCT family transporter; Region: BCCT; pfam02028 911045006419 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 911045006420 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 911045006421 active site pocket [active] 911045006422 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 911045006423 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 911045006424 Protein of unknown function (DUF4246); Region: DUF4246; pfam14033 911045006425 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 911045006426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045006427 DNA-binding site [nucleotide binding]; DNA binding site 911045006428 FCD domain; Region: FCD; pfam07729 911045006429 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 911045006430 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 911045006431 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 911045006432 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 911045006433 Walker A/P-loop; other site 911045006434 ATP binding site [chemical binding]; other site 911045006435 Q-loop/lid; other site 911045006436 ABC transporter signature motif; other site 911045006437 Walker B; other site 911045006438 D-loop; other site 911045006439 H-loop/switch region; other site 911045006440 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 911045006441 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 911045006442 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045006443 TM-ABC transporter signature motif; other site 911045006444 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 911045006445 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 911045006446 putative ligand binding site [chemical binding]; other site 911045006447 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 911045006448 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045006449 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 911045006450 Amidase; Region: Amidase; cl11426 911045006451 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 911045006452 HTH domain; Region: HTH_11; pfam08279 911045006453 WYL domain; Region: WYL; pfam13280 911045006454 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 911045006455 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045006456 DctM-like transporters; Region: DctM; pfam06808 911045006457 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 911045006458 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 911045006459 active site 911045006460 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045006461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045006462 Walker A/P-loop; other site 911045006463 ATP binding site [chemical binding]; other site 911045006464 Q-loop/lid; other site 911045006465 ABC transporter signature motif; other site 911045006466 Walker B; other site 911045006467 D-loop; other site 911045006468 H-loop/switch region; other site 911045006469 TOBE domain; Region: TOBE_2; pfam08402 911045006470 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 911045006471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006472 dimer interface [polypeptide binding]; other site 911045006473 conserved gate region; other site 911045006474 putative PBP binding loops; other site 911045006475 ABC-ATPase subunit interface; other site 911045006476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006477 dimer interface [polypeptide binding]; other site 911045006478 conserved gate region; other site 911045006479 putative PBP binding loops; other site 911045006480 ABC-ATPase subunit interface; other site 911045006481 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045006482 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 911045006483 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045006484 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045006485 DNA binding site [nucleotide binding] 911045006486 domain linker motif; other site 911045006487 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 911045006488 putative dimerization interface [polypeptide binding]; other site 911045006489 putative ligand binding site [chemical binding]; other site 911045006490 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 911045006491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006492 NAD(P) binding site [chemical binding]; other site 911045006493 active site 911045006494 Flavoprotein; Region: Flavoprotein; pfam02441 911045006495 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 911045006496 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 911045006497 active site 911045006498 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 911045006499 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 911045006500 transmembrane helices; other site 911045006501 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 911045006502 homodimer interaction site [polypeptide binding]; other site 911045006503 cofactor binding site; other site 911045006504 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045006505 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045006506 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045006507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 911045006508 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 911045006509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006510 dimer interface [polypeptide binding]; other site 911045006511 conserved gate region; other site 911045006512 putative PBP binding loops; other site 911045006513 ABC-ATPase subunit interface; other site 911045006514 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 911045006515 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045006516 Walker A/P-loop; other site 911045006517 ATP binding site [chemical binding]; other site 911045006518 Q-loop/lid; other site 911045006519 ABC transporter signature motif; other site 911045006520 Walker B; other site 911045006521 D-loop; other site 911045006522 H-loop/switch region; other site 911045006523 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045006524 Walker A/P-loop; other site 911045006525 ATP binding site [chemical binding]; other site 911045006526 Q-loop/lid; other site 911045006527 ABC transporter signature motif; other site 911045006528 Walker B; other site 911045006529 D-loop; other site 911045006530 H-loop/switch region; other site 911045006531 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 911045006532 putative active site pocket [active] 911045006533 dimerization interface [polypeptide binding]; other site 911045006534 putative catalytic residue [active] 911045006535 Peptidase family M23; Region: Peptidase_M23; pfam01551 911045006536 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045006537 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 911045006538 active site 911045006539 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045006540 active site 911045006541 Prephenate dehydratase; Region: PDT; pfam00800 911045006542 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045006543 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045006544 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 911045006545 putative N-terminal domain interface [polypeptide binding]; other site 911045006546 putative dimer interface [polypeptide binding]; other site 911045006547 putative substrate binding pocket (H-site) [chemical binding]; other site 911045006548 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045006549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045006550 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045006551 dimerization interface [polypeptide binding]; other site 911045006552 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045006553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045006554 putative DNA binding site [nucleotide binding]; other site 911045006555 putative Zn2+ binding site [ion binding]; other site 911045006556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045006557 dimerization interface [polypeptide binding]; other site 911045006558 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045006559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045006560 substrate binding pocket [chemical binding]; other site 911045006561 membrane-bound complex binding site; other site 911045006562 hinge residues; other site 911045006563 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045006564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006565 dimer interface [polypeptide binding]; other site 911045006566 conserved gate region; other site 911045006567 putative PBP binding loops; other site 911045006568 ABC-ATPase subunit interface; other site 911045006569 Peptidase C26; Region: Peptidase_C26; pfam07722 911045006570 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 911045006571 catalytic triad [active] 911045006572 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 911045006573 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 911045006574 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 911045006575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045006576 catalytic core [active] 911045006577 DctM-like transporters; Region: DctM; pfam06808 911045006578 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045006579 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045006580 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045006581 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045006582 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 911045006583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045006584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045006585 dimerization interface [polypeptide binding]; other site 911045006586 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 911045006587 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 911045006588 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 911045006589 heterodimer interface [polypeptide binding]; other site 911045006590 multimer interface [polypeptide binding]; other site 911045006591 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 911045006592 active site 911045006593 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 911045006594 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 911045006595 heterodimer interface [polypeptide binding]; other site 911045006596 active site 911045006597 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 911045006598 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 911045006599 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 911045006600 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 911045006601 dimer interface [polypeptide binding]; other site 911045006602 active site 911045006603 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 911045006604 Lyase; Region: Lyase_1; pfam00206 911045006605 tetramer interface [polypeptide binding]; other site 911045006606 hypothetical protein; Provisional; Region: PRK07079 911045006607 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 911045006608 metal binding site [ion binding]; metal-binding site 911045006609 putative dimer interface [polypeptide binding]; other site 911045006610 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 911045006611 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 911045006612 Baseplate J-like protein; Region: Baseplate_J; cl01294 911045006613 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 911045006614 SEFIR domain; Region: SEFIR; pfam08357 911045006615 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 911045006616 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 911045006617 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 911045006618 tape measure domain; Region: tape_meas_nterm; TIGR02675 911045006619 membrane protein P6; Region: PHA01399 911045006620 Phage tail tube protein FII; Region: Phage_tube; cl01390 911045006621 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 911045006622 Gp37 protein; Region: Gp37; pfam09646 911045006623 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 911045006624 Transposase; Region: HTH_Tnp_1; cl17663 911045006625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 911045006626 Helix-turn-helix domain; Region: HTH_28; pfam13518 911045006627 Winged helix-turn helix; Region: HTH_29; pfam13551 911045006628 Homeodomain-like domain; Region: HTH_32; pfam13565 911045006629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 911045006630 Integrase core domain; Region: rve; pfam00665 911045006631 multidrug efflux protein; Reviewed; Region: PRK09579 911045006632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045006633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045006634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045006635 binding surface 911045006636 TPR motif; other site 911045006637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045006638 S-adenosylmethionine binding site [chemical binding]; other site 911045006639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006640 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045006641 NAD(P) binding site [chemical binding]; other site 911045006642 active site 911045006643 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045006644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045006645 NAD(P) binding site [chemical binding]; other site 911045006646 active site 911045006647 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045006648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045006649 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045006650 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045006651 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045006652 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045006653 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 911045006654 active site 911045006655 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 911045006656 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 911045006657 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045006658 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 911045006659 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045006660 SnoaL-like domain; Region: SnoaL_4; cl17707 911045006661 SnoaL-like domain; Region: SnoaL_4; pfam13577 911045006662 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045006663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045006664 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045006665 substrate binding pocket [chemical binding]; other site 911045006666 dimerization interface [polypeptide binding]; other site 911045006667 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 911045006668 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 911045006669 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 911045006670 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 911045006671 Class I ribonucleotide reductase; Region: RNR_I; cd01679 911045006672 active site 911045006673 dimer interface [polypeptide binding]; other site 911045006674 catalytic residues [active] 911045006675 effector binding site; other site 911045006676 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 911045006677 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 911045006678 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 911045006679 dimer interface [polypeptide binding]; other site 911045006680 putative radical transfer pathway; other site 911045006681 diiron center [ion binding]; other site 911045006682 tyrosyl radical; other site 911045006683 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045006684 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045006685 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045006686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045006687 DNA-binding site [nucleotide binding]; DNA binding site 911045006688 FCD domain; Region: FCD; pfam07729 911045006689 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 911045006690 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 911045006691 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 911045006692 DctM-like transporters; Region: DctM; pfam06808 911045006693 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045006694 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 911045006695 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 911045006696 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 911045006697 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 911045006698 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 911045006699 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045006700 substrate binding site [chemical binding]; other site 911045006701 ATP binding site [chemical binding]; other site 911045006702 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 911045006703 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 911045006704 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 911045006705 active site 911045006706 catalytic residues [active] 911045006707 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045006708 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 911045006709 intersubunit interface [polypeptide binding]; other site 911045006710 active site 911045006711 zinc binding site [ion binding]; other site 911045006712 Na+ binding site [ion binding]; other site 911045006713 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 911045006714 hexamer (dimer of trimers) interface [polypeptide binding]; other site 911045006715 trimer interface [polypeptide binding]; other site 911045006716 substrate binding site [chemical binding]; other site 911045006717 Mn binding site [ion binding]; other site 911045006718 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 911045006719 DctM-like transporters; Region: DctM; pfam06808 911045006720 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045006721 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045006722 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045006723 alpha-glucosidase; Provisional; Region: PRK10426 911045006724 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 911045006725 putative active site [active] 911045006726 putative catalytic site [active] 911045006727 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 911045006728 Dak1 domain; Region: Dak1; pfam02733 911045006729 DAK2 domain; Region: Dak2; cl03685 911045006730 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 911045006731 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 911045006732 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 911045006733 dimerization domain swap beta strand [polypeptide binding]; other site 911045006734 regulatory protein interface [polypeptide binding]; other site 911045006735 active site 911045006736 regulatory phosphorylation site [posttranslational modification]; other site 911045006737 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 911045006738 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 911045006739 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 911045006740 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 911045006741 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 911045006742 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 911045006743 dimer interface [polypeptide binding]; other site 911045006744 active site 911045006745 metal binding site [ion binding]; metal-binding site 911045006746 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 911045006747 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 911045006748 putative DNA binding site [nucleotide binding]; other site 911045006749 putative Zn2+ binding site [ion binding]; other site 911045006750 AsnC family; Region: AsnC_trans_reg; pfam01037 911045006751 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 911045006752 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 911045006753 metal binding site [ion binding]; metal-binding site 911045006754 putative dimer interface [polypeptide binding]; other site 911045006755 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 911045006756 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 911045006757 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045006758 catalytic residue [active] 911045006759 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 911045006760 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045006761 Walker A/P-loop; other site 911045006762 ATP binding site [chemical binding]; other site 911045006763 Q-loop/lid; other site 911045006764 ABC transporter signature motif; other site 911045006765 Walker B; other site 911045006766 D-loop; other site 911045006767 H-loop/switch region; other site 911045006768 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 911045006769 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045006770 ABC-ATPase subunit interface; other site 911045006771 dimer interface [polypeptide binding]; other site 911045006772 putative PBP binding regions; other site 911045006773 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 911045006774 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045006775 ABC-ATPase subunit interface; other site 911045006776 dimer interface [polypeptide binding]; other site 911045006777 putative PBP binding regions; other site 911045006778 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 911045006779 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 911045006780 siderophore binding site; other site 911045006781 putative MFS family transporter protein; Provisional; Region: PRK03633 911045006782 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 911045006783 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 911045006784 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 911045006785 Ligand binding site; other site 911045006786 Putative Catalytic site; other site 911045006787 DXD motif; other site 911045006788 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 911045006789 putative homodimer interface [polypeptide binding]; other site 911045006790 putative active site [active] 911045006791 YdjC motif; other site 911045006792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045006793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045006794 Coenzyme A binding pocket [chemical binding]; other site 911045006795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045006796 Coenzyme A binding pocket [chemical binding]; other site 911045006797 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 911045006798 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 911045006799 N- and C-terminal domain interface [polypeptide binding]; other site 911045006800 active site 911045006801 MgATP binding site [chemical binding]; other site 911045006802 catalytic site [active] 911045006803 metal binding site [ion binding]; metal-binding site 911045006804 carbohydrate binding site [chemical binding]; other site 911045006805 putative homodimer interface [polypeptide binding]; other site 911045006806 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045006807 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045006808 DNA binding site [nucleotide binding] 911045006809 domain linker motif; other site 911045006810 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045006811 SnoaL-like domain; Region: SnoaL_4; pfam13577 911045006812 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 911045006813 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 911045006814 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 911045006815 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 911045006816 G1 box; other site 911045006817 GTP/Mg2+ binding site [chemical binding]; other site 911045006818 G2 box; other site 911045006819 Switch I region; other site 911045006820 G3 box; other site 911045006821 Switch II region; other site 911045006822 G4 box; other site 911045006823 G5 box; other site 911045006824 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 911045006825 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 911045006826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045006827 S-adenosylmethionine binding site [chemical binding]; other site 911045006828 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 911045006829 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 911045006830 active site 911045006831 uracil binding [chemical binding]; other site 911045006832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045006833 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045006834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045006835 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 911045006836 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 911045006837 Ion channel; Region: Ion_trans_2; pfam07885 911045006838 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 911045006839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045006840 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 911045006841 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 911045006842 ABC transporter signature motif; other site 911045006843 Walker B; other site 911045006844 D-loop; other site 911045006845 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 911045006846 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 911045006847 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 911045006848 peptide binding site [polypeptide binding]; other site 911045006849 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 911045006850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006851 dimer interface [polypeptide binding]; other site 911045006852 conserved gate region; other site 911045006853 putative PBP binding loops; other site 911045006854 ABC-ATPase subunit interface; other site 911045006855 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045006856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045006857 dimer interface [polypeptide binding]; other site 911045006858 conserved gate region; other site 911045006859 ABC-ATPase subunit interface; other site 911045006860 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 911045006861 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045006862 Walker A/P-loop; other site 911045006863 ATP binding site [chemical binding]; other site 911045006864 Q-loop/lid; other site 911045006865 ABC transporter signature motif; other site 911045006866 Walker B; other site 911045006867 D-loop; other site 911045006868 H-loop/switch region; other site 911045006869 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 911045006870 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045006871 Walker A/P-loop; other site 911045006872 ATP binding site [chemical binding]; other site 911045006873 Q-loop/lid; other site 911045006874 ABC transporter signature motif; other site 911045006875 Walker B; other site 911045006876 D-loop; other site 911045006877 H-loop/switch region; other site 911045006878 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 911045006879 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045006880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045006881 putative DNA binding site [nucleotide binding]; other site 911045006882 putative Zn2+ binding site [ion binding]; other site 911045006883 AsnC family; Region: AsnC_trans_reg; pfam01037 911045006884 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 911045006885 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 911045006886 active site 911045006887 dimer interface [polypeptide binding]; other site 911045006888 Cupin domain; Region: Cupin_2; cl17218 911045006889 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 911045006890 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 911045006891 HerA helicase [Replication, recombination, and repair]; Region: COG0433 911045006892 AAA ATPase domain; Region: AAA_16; pfam13191 911045006893 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045006894 EamA-like transporter family; Region: EamA; pfam00892 911045006895 EamA-like transporter family; Region: EamA; pfam00892 911045006896 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 911045006897 active site 911045006898 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 911045006899 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 911045006900 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045006901 dimerization interface [polypeptide binding]; other site 911045006902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045006903 dimer interface [polypeptide binding]; other site 911045006904 phosphorylation site [posttranslational modification] 911045006905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045006906 ATP binding site [chemical binding]; other site 911045006907 Mg2+ binding site [ion binding]; other site 911045006908 G-X-G motif; other site 911045006909 osmolarity response regulator; Provisional; Region: ompR; PRK09468 911045006910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045006911 active site 911045006912 phosphorylation site [posttranslational modification] 911045006913 intermolecular recognition site; other site 911045006914 dimerization interface [polypeptide binding]; other site 911045006915 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045006916 DNA binding site [nucleotide binding] 911045006917 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 911045006918 EF-hand domain pair; Region: EF_hand_5; pfam13499 911045006919 Ca2+ binding site [ion binding]; other site 911045006920 Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; Region: FRQ1; COG5126 911045006921 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 911045006922 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 911045006923 Sulfate transporter family; Region: Sulfate_transp; pfam00916 911045006924 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 911045006925 hypothetical protein; Provisional; Region: PRK08912 911045006926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045006927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045006928 homodimer interface [polypeptide binding]; other site 911045006929 catalytic residue [active] 911045006930 L-asparaginase II; Region: Asparaginase_II; pfam06089 911045006931 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 911045006932 Right handed beta helix region; Region: Beta_helix; pfam13229 911045006933 Right handed beta helix region; Region: Beta_helix; pfam13229 911045006934 membrane ATPase/protein kinase; Provisional; Region: PRK09435 911045006935 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 911045006936 Walker A; other site 911045006937 hypothetical protein; Provisional; Region: PRK02877 911045006938 hypothetical protein; Provisional; Region: PRK06194 911045006939 classical (c) SDRs; Region: SDR_c; cd05233 911045006940 NAD(P) binding site [chemical binding]; other site 911045006941 active site 911045006942 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 911045006943 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 911045006944 active site 911045006945 substrate binding site [chemical binding]; other site 911045006946 coenzyme B12 binding site [chemical binding]; other site 911045006947 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 911045006948 B12 binding site [chemical binding]; other site 911045006949 cobalt ligand [ion binding]; other site 911045006950 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 911045006951 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 911045006952 heterodimer interface [polypeptide binding]; other site 911045006953 substrate interaction site [chemical binding]; other site 911045006954 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 911045006955 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 911045006956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045006957 DNA binding residues [nucleotide binding] 911045006958 dimerization interface [polypeptide binding]; other site 911045006959 galactokinase; Provisional; Region: PRK03817 911045006960 hypothetical protein; Validated; Region: PRK09104 911045006961 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 911045006962 metal binding site [ion binding]; metal-binding site 911045006963 putative dimer interface [polypeptide binding]; other site 911045006964 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 911045006965 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 911045006966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045006967 motif II; other site 911045006968 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 911045006969 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 911045006970 homodimer interface [polypeptide binding]; other site 911045006971 substrate-cofactor binding pocket; other site 911045006972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045006973 catalytic residue [active] 911045006974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045006975 putative substrate translocation pore; other site 911045006976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045006977 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 911045006978 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 911045006979 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 911045006980 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 911045006981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045006982 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 911045006983 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 911045006984 [2Fe-2S] cluster binding site [ion binding]; other site 911045006985 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 911045006986 alpha subunit interface [polypeptide binding]; other site 911045006987 active site 911045006988 substrate binding site [chemical binding]; other site 911045006989 Fe binding site [ion binding]; other site 911045006990 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 911045006991 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 911045006992 FAD binding pocket [chemical binding]; other site 911045006993 FAD binding motif [chemical binding]; other site 911045006994 phosphate binding motif [ion binding]; other site 911045006995 beta-alpha-beta structure motif; other site 911045006996 NAD(p) ribose binding residues [chemical binding]; other site 911045006997 NAD binding pocket [chemical binding]; other site 911045006998 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 911045006999 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045007000 catalytic loop [active] 911045007001 iron binding site [ion binding]; other site 911045007002 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 911045007003 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 911045007004 methionine sulfoxide reductase B; Provisional; Region: PRK00222 911045007005 SelR domain; Region: SelR; pfam01641 911045007006 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 911045007007 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 911045007008 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 911045007009 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 911045007010 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 911045007011 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 911045007012 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 911045007013 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 911045007014 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 911045007015 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 911045007016 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 911045007017 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 911045007018 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 911045007019 DnaA box-binding interface [nucleotide binding]; other site 911045007020 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 911045007021 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 911045007022 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 911045007023 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 911045007024 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 911045007025 Predicted integral membrane protein [Function unknown]; Region: COG5436 911045007026 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 911045007027 Transglycosylase; Region: Transgly; pfam00912 911045007028 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 911045007029 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 911045007030 Flagellin N-methylase; Region: FliB; cl00497 911045007031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045007032 Uncharacterized conserved protein [Function unknown]; Region: COG5323 911045007033 Terminase-like family; Region: Terminase_6; pfam03237 911045007034 Phage-related protein [Function unknown]; Region: COG4695 911045007035 Phage portal protein; Region: Phage_portal; pfam04860 911045007036 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 911045007037 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 911045007038 Phage capsid family; Region: Phage_capsid; pfam05065 911045007039 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 911045007040 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 911045007041 oligomerization interface [polypeptide binding]; other site 911045007042 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 911045007043 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 911045007044 Phage major tail protein 2; Region: Phage_tail_2; cl11463 911045007045 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 911045007046 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550 911045007047 Phage-related minor tail protein [Function unknown]; Region: COG5281 911045007048 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 911045007049 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 911045007050 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 911045007051 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 911045007052 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 911045007053 NlpC/P60 family; Region: NLPC_P60; cl17555 911045007054 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 911045007055 Putative phage tail protein; Region: Phage-tail_3; pfam13550 911045007056 Predicted membrane protein [Function unknown]; Region: COG3212 911045007057 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045007058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045007059 active site 911045007060 phosphorylation site [posttranslational modification] 911045007061 intermolecular recognition site; other site 911045007062 dimerization interface [polypeptide binding]; other site 911045007063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045007064 DNA binding site [nucleotide binding] 911045007065 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 911045007066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045007067 ATP binding site [chemical binding]; other site 911045007068 Mg2+ binding site [ion binding]; other site 911045007069 G-X-G motif; other site 911045007070 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 911045007071 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 911045007072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045007073 binding surface 911045007074 TPR motif; other site 911045007075 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 911045007076 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 911045007077 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 911045007078 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 911045007079 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 911045007080 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 911045007081 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045007082 protein binding site [polypeptide binding]; other site 911045007083 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045007084 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045007085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045007086 active site 911045007087 phosphorylation site [posttranslational modification] 911045007088 intermolecular recognition site; other site 911045007089 dimerization interface [polypeptide binding]; other site 911045007090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045007091 DNA binding site [nucleotide binding] 911045007092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045007093 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045007094 dimerization interface [polypeptide binding]; other site 911045007095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045007096 dimer interface [polypeptide binding]; other site 911045007097 phosphorylation site [posttranslational modification] 911045007098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045007099 ATP binding site [chemical binding]; other site 911045007100 Mg2+ binding site [ion binding]; other site 911045007101 G-X-G motif; other site 911045007102 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 911045007103 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 911045007104 metal binding triad; other site 911045007105 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 911045007106 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 911045007107 metal binding triad; other site 911045007108 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 911045007109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045007110 PAS fold; Region: PAS_3; pfam08447 911045007111 putative active site [active] 911045007112 heme pocket [chemical binding]; other site 911045007113 PAS fold; Region: PAS_7; pfam12860 911045007114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045007115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045007116 dimer interface [polypeptide binding]; other site 911045007117 phosphorylation site [posttranslational modification] 911045007118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045007119 ATP binding site [chemical binding]; other site 911045007120 Mg2+ binding site [ion binding]; other site 911045007121 G-X-G motif; other site 911045007122 aminopeptidase N; Provisional; Region: pepN; PRK14015 911045007123 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 911045007124 active site 911045007125 Zn binding site [ion binding]; other site 911045007126 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045007127 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045007128 HAMP domain; Region: HAMP; pfam00672 911045007129 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 911045007130 cyclase homology domain; Region: CHD; cd07302 911045007131 nucleotidyl binding site; other site 911045007132 metal binding site [ion binding]; metal-binding site 911045007133 dimer interface [polypeptide binding]; other site 911045007134 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 911045007135 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045007136 Walker A/P-loop; other site 911045007137 ATP binding site [chemical binding]; other site 911045007138 Q-loop/lid; other site 911045007139 ABC transporter signature motif; other site 911045007140 Walker B; other site 911045007141 D-loop; other site 911045007142 H-loop/switch region; other site 911045007143 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045007144 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045007145 Walker A/P-loop; other site 911045007146 ATP binding site [chemical binding]; other site 911045007147 Q-loop/lid; other site 911045007148 ABC transporter signature motif; other site 911045007149 Walker B; other site 911045007150 D-loop; other site 911045007151 H-loop/switch region; other site 911045007152 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 911045007153 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 911045007154 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045007155 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045007156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007157 dimer interface [polypeptide binding]; other site 911045007158 conserved gate region; other site 911045007159 putative PBP binding loops; other site 911045007160 ABC-ATPase subunit interface; other site 911045007161 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045007162 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 911045007163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007164 dimer interface [polypeptide binding]; other site 911045007165 conserved gate region; other site 911045007166 putative PBP binding loops; other site 911045007167 ABC-ATPase subunit interface; other site 911045007168 Methyltransferase domain; Region: Methyltransf_23; pfam13489 911045007169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045007170 S-adenosylmethionine binding site [chemical binding]; other site 911045007171 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 911045007172 NodB motif; other site 911045007173 putative active site [active] 911045007174 putative catalytic site [active] 911045007175 putative Zn binding site [ion binding]; other site 911045007176 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 911045007177 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 911045007178 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045007179 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045007180 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 911045007181 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 911045007182 putative ADP-binding pocket [chemical binding]; other site 911045007183 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 911045007184 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 911045007185 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 911045007186 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045007187 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 911045007188 Walker A/P-loop; other site 911045007189 ATP binding site [chemical binding]; other site 911045007190 Q-loop/lid; other site 911045007191 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 911045007192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045007193 ABC transporter signature motif; other site 911045007194 Walker B; other site 911045007195 D-loop; other site 911045007196 H-loop/switch region; other site 911045007197 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045007198 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045007199 ligand binding site [chemical binding]; other site 911045007200 flexible hinge region; other site 911045007201 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 911045007202 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 911045007203 cyclase homology domain; Region: CHD; cd07302 911045007204 nucleotidyl binding site; other site 911045007205 metal binding site [ion binding]; metal-binding site 911045007206 dimer interface [polypeptide binding]; other site 911045007207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045007208 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 911045007209 NAD(P) binding site [chemical binding]; other site 911045007210 active site 911045007211 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045007212 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 911045007213 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045007214 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045007215 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 911045007216 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 911045007217 putative peroxiredoxin; Provisional; Region: PRK13190 911045007218 decamer (pentamer of dimers) interface [polypeptide binding]; other site 911045007219 catalytic triad [active] 911045007220 dimer interface [polypeptide binding]; other site 911045007221 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 911045007222 putative hydrophobic ligand binding site [chemical binding]; other site 911045007223 CLM binding site; other site 911045007224 L1 loop; other site 911045007225 DNA binding site [nucleotide binding] 911045007226 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 911045007227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007228 dimer interface [polypeptide binding]; other site 911045007229 conserved gate region; other site 911045007230 putative PBP binding loops; other site 911045007231 ABC-ATPase subunit interface; other site 911045007232 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 911045007233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 911045007234 Walker A/P-loop; other site 911045007235 ATP binding site [chemical binding]; other site 911045007236 Q-loop/lid; other site 911045007237 ABC transporter signature motif; other site 911045007238 Walker B; other site 911045007239 D-loop; other site 911045007240 H-loop/switch region; other site 911045007241 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 911045007242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045007243 substrate binding pocket [chemical binding]; other site 911045007244 membrane-bound complex binding site; other site 911045007245 hinge residues; other site 911045007246 anthranilate synthase; Provisional; Region: PRK13566 911045007247 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 911045007248 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 911045007249 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 911045007250 glutamine binding [chemical binding]; other site 911045007251 catalytic triad [active] 911045007252 acetylornithine deacetylase; Provisional; Region: PRK07522 911045007253 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 911045007254 metal binding site [ion binding]; metal-binding site 911045007255 putative dimer interface [polypeptide binding]; other site 911045007256 fructokinase; Reviewed; Region: PRK09557 911045007257 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 911045007258 nucleotide binding site [chemical binding]; other site 911045007259 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 911045007260 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 911045007261 intersubunit interface [polypeptide binding]; other site 911045007262 active site 911045007263 Zn2+ binding site [ion binding]; other site 911045007264 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 911045007265 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045007266 Walker A/P-loop; other site 911045007267 ATP binding site [chemical binding]; other site 911045007268 Q-loop/lid; other site 911045007269 ABC transporter signature motif; other site 911045007270 Walker B; other site 911045007271 D-loop; other site 911045007272 H-loop/switch region; other site 911045007273 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045007274 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045007275 Walker A/P-loop; other site 911045007276 ATP binding site [chemical binding]; other site 911045007277 Q-loop/lid; other site 911045007278 ABC transporter signature motif; other site 911045007279 Walker B; other site 911045007280 D-loop; other site 911045007281 H-loop/switch region; other site 911045007282 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 911045007283 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 911045007284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007285 dimer interface [polypeptide binding]; other site 911045007286 conserved gate region; other site 911045007287 putative PBP binding loops; other site 911045007288 ABC-ATPase subunit interface; other site 911045007289 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045007290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007291 dimer interface [polypeptide binding]; other site 911045007292 conserved gate region; other site 911045007293 putative PBP binding loops; other site 911045007294 ABC-ATPase subunit interface; other site 911045007295 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045007296 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 911045007297 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 911045007298 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 911045007299 metal binding site [ion binding]; metal-binding site 911045007300 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 911045007301 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 911045007302 Substrate binding site; other site 911045007303 Cupin domain; Region: Cupin_2; cl17218 911045007304 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 911045007305 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 911045007306 active site 911045007307 substrate binding site [chemical binding]; other site 911045007308 metal binding site [ion binding]; metal-binding site 911045007309 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045007310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045007311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045007312 dimerization interface [polypeptide binding]; other site 911045007313 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 911045007314 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 911045007315 tetrameric interface [polypeptide binding]; other site 911045007316 NAD binding site [chemical binding]; other site 911045007317 catalytic residues [active] 911045007318 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 911045007319 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045007320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045007321 Walker A/P-loop; other site 911045007322 ATP binding site [chemical binding]; other site 911045007323 Q-loop/lid; other site 911045007324 ABC transporter signature motif; other site 911045007325 Walker B; other site 911045007326 D-loop; other site 911045007327 H-loop/switch region; other site 911045007328 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 911045007329 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 911045007330 Walker A/P-loop; other site 911045007331 ATP binding site [chemical binding]; other site 911045007332 Q-loop/lid; other site 911045007333 Walker B; other site 911045007334 D-loop; other site 911045007335 H-loop/switch region; other site 911045007336 RibD C-terminal domain; Region: RibD_C; cl17279 911045007337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045007338 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 911045007339 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 911045007340 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 911045007341 putative DNA binding site [nucleotide binding]; other site 911045007342 putative Zn2+ binding site [ion binding]; other site 911045007343 AsnC family; Region: AsnC_trans_reg; pfam01037 911045007344 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 911045007345 intersubunit interface [polypeptide binding]; other site 911045007346 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 911045007347 metal binding site [ion binding]; metal-binding site 911045007348 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045007349 MarR family; Region: MarR; pfam01047 911045007350 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045007351 EamA-like transporter family; Region: EamA; pfam00892 911045007352 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 911045007353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 911045007354 Cupin domain; Region: Cupin_2; pfam07883 911045007355 Uncharacterized conserved protein [Function unknown]; Region: COG1359 911045007356 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045007357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045007358 dimerization interface [polypeptide binding]; other site 911045007359 putative DNA binding site [nucleotide binding]; other site 911045007360 putative Zn2+ binding site [ion binding]; other site 911045007361 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 911045007362 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 911045007363 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045007364 Sel1 repeat; Region: Sel1; cl02723 911045007365 Sel1-like repeats; Region: SEL1; smart00671 911045007366 Sel1-like repeats; Region: SEL1; smart00671 911045007367 Sel1-like repeats; Region: SEL1; smart00671 911045007368 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 911045007369 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 911045007370 FMN binding site [chemical binding]; other site 911045007371 active site 911045007372 catalytic residues [active] 911045007373 substrate binding site [chemical binding]; other site 911045007374 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045007375 Predicted aspartyl protease [General function prediction only]; Region: COG3577 911045007376 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 911045007377 catalytic motif [active] 911045007378 Catalytic residue [active] 911045007379 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 911045007380 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 911045007381 cobalamin synthase; Reviewed; Region: cobS; PRK00235 911045007382 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 911045007383 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 911045007384 putative dimer interface [polypeptide binding]; other site 911045007385 active site pocket [active] 911045007386 putative cataytic base [active] 911045007387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045007388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045007389 dimer interface [polypeptide binding]; other site 911045007390 phosphorylation site [posttranslational modification] 911045007391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045007392 ATP binding site [chemical binding]; other site 911045007393 Mg2+ binding site [ion binding]; other site 911045007394 G-X-G motif; other site 911045007395 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045007396 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045007397 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 911045007398 putative N-terminal domain interface [polypeptide binding]; other site 911045007399 putative dimer interface [polypeptide binding]; other site 911045007400 putative substrate binding pocket (H-site) [chemical binding]; other site 911045007401 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 911045007402 ligand binding site [chemical binding]; other site 911045007403 active site 911045007404 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045007405 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045007406 putative DNA binding site [nucleotide binding]; other site 911045007407 putative Zn2+ binding site [ion binding]; other site 911045007408 AsnC family; Region: AsnC_trans_reg; pfam01037 911045007409 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 911045007410 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 911045007411 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045007412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007413 dimer interface [polypeptide binding]; other site 911045007414 conserved gate region; other site 911045007415 putative PBP binding loops; other site 911045007416 ABC-ATPase subunit interface; other site 911045007417 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 911045007418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007419 dimer interface [polypeptide binding]; other site 911045007420 conserved gate region; other site 911045007421 putative PBP binding loops; other site 911045007422 ABC-ATPase subunit interface; other site 911045007423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045007424 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045007425 substrate binding pocket [chemical binding]; other site 911045007426 membrane-bound complex binding site; other site 911045007427 hinge residues; other site 911045007428 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045007429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045007430 substrate binding pocket [chemical binding]; other site 911045007431 membrane-bound complex binding site; other site 911045007432 hinge residues; other site 911045007433 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045007434 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045007435 substrate binding pocket [chemical binding]; other site 911045007436 membrane-bound complex binding site; other site 911045007437 hinge residues; other site 911045007438 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 911045007439 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 911045007440 dimer interface [polypeptide binding]; other site 911045007441 putative functional site; other site 911045007442 putative MPT binding site; other site 911045007443 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 911045007444 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 911045007445 GTP binding site; other site 911045007446 Sensors of blue-light using FAD; Region: BLUF; cl04855 911045007447 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 911045007448 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 911045007449 active site 911045007450 metal binding site [ion binding]; metal-binding site 911045007451 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 911045007452 Domain of unknown function DUF59; Region: DUF59; pfam01883 911045007453 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 911045007454 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 911045007455 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045007456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045007457 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045007458 dimerization interface [polypeptide binding]; other site 911045007459 substrate binding pocket [chemical binding]; other site 911045007460 Flp/Fap pilin component; Region: Flp_Fap; cl01585 911045007461 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 911045007462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045007463 FeS/SAM binding site; other site 911045007464 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 911045007465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 911045007466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 911045007467 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 911045007468 fumarate hydratase; Provisional; Region: PRK15389 911045007469 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 911045007470 Fumarase C-terminus; Region: Fumerase_C; pfam05683 911045007471 YceI-like domain; Region: YceI; pfam04264 911045007472 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 911045007473 Uncharacterized conserved protein [Function unknown]; Region: COG2353 911045007474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045007475 S-adenosylmethionine binding site [chemical binding]; other site 911045007476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045007477 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045007478 succinic semialdehyde dehydrogenase; Region: PLN02278 911045007479 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 911045007480 tetramerization interface [polypeptide binding]; other site 911045007481 NAD(P) binding site [chemical binding]; other site 911045007482 catalytic residues [active] 911045007483 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 911045007484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 911045007485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 911045007486 Family of unknown function (DUF490); Region: DUF490; pfam04357 911045007487 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 911045007488 Surface antigen; Region: Bac_surface_Ag; pfam01103 911045007489 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 911045007490 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 911045007491 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 911045007492 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 911045007493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045007494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045007495 active site 911045007496 intermolecular recognition site; other site 911045007497 dimerization interface [polypeptide binding]; other site 911045007498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045007499 DNA binding site [nucleotide binding] 911045007500 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 911045007501 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 911045007502 Walker A motif; other site 911045007503 ATP binding site [chemical binding]; other site 911045007504 Walker B motif; other site 911045007505 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 911045007506 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 911045007507 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 911045007508 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 911045007509 flagellar motor protein MotA; Validated; Region: PRK09110 911045007510 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 911045007511 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 911045007512 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 911045007513 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 911045007514 FliG C-terminal domain; Region: FliG_C; pfam01706 911045007515 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109 911045007516 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 911045007517 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 911045007518 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 911045007519 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 911045007520 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 911045007521 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 911045007522 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 911045007523 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 911045007524 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 911045007525 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 911045007526 Flagellar P-ring protein; Region: FlgI; pfam02119 911045007527 Uncharacterized conserved protein [Function unknown]; Region: COG3334 911045007528 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 911045007529 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 911045007530 FliP family; Region: FliP; cl00593 911045007531 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 911045007532 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 911045007533 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 911045007534 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 911045007535 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 911045007536 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 911045007537 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 911045007538 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 911045007539 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 911045007540 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 911045007541 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045007542 ligand binding site [chemical binding]; other site 911045007543 chemotaxis protein; Reviewed; Region: PRK12798 911045007544 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 911045007545 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 911045007546 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 911045007547 N-acetyl-D-glucosamine binding site [chemical binding]; other site 911045007548 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 911045007549 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 911045007550 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 911045007551 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 911045007552 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 911045007553 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 911045007554 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 911045007555 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 911045007556 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 911045007557 Flagellar protein FlaF; Region: FlaF; pfam07309 911045007558 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 911045007559 Flagellar protein FlbT; Region: FlbT; cl11455 911045007560 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 911045007561 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 911045007562 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK12781 911045007563 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 911045007564 FHIPEP family; Region: FHIPEP; pfam00771 911045007565 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 911045007566 Rod binding protein; Region: Rod-binding; pfam10135 911045007567 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 911045007568 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045007569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045007570 DNA-binding site [nucleotide binding]; DNA binding site 911045007571 FCD domain; Region: FCD; pfam07729 911045007572 SlyX; Region: SlyX; pfam04102 911045007573 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 911045007574 DNA binding residues [nucleotide binding] 911045007575 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 911045007576 putative dimer interface [polypeptide binding]; other site 911045007577 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045007578 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 911045007579 peptide binding site [polypeptide binding]; other site 911045007580 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045007581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007582 dimer interface [polypeptide binding]; other site 911045007583 conserved gate region; other site 911045007584 putative PBP binding loops; other site 911045007585 ABC-ATPase subunit interface; other site 911045007586 dipeptide transporter; Provisional; Region: PRK10913 911045007587 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045007588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045007589 putative PBP binding loops; other site 911045007590 dimer interface [polypeptide binding]; other site 911045007591 ABC-ATPase subunit interface; other site 911045007592 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045007593 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045007594 Walker A/P-loop; other site 911045007595 ATP binding site [chemical binding]; other site 911045007596 Q-loop/lid; other site 911045007597 ABC transporter signature motif; other site 911045007598 Walker B; other site 911045007599 D-loop; other site 911045007600 H-loop/switch region; other site 911045007601 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045007602 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045007603 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045007604 Walker A/P-loop; other site 911045007605 ATP binding site [chemical binding]; other site 911045007606 Q-loop/lid; other site 911045007607 ABC transporter signature motif; other site 911045007608 Walker B; other site 911045007609 D-loop; other site 911045007610 H-loop/switch region; other site 911045007611 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045007612 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045007613 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 911045007614 peptide binding site [polypeptide binding]; other site 911045007615 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 911045007616 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 911045007617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045007618 catalytic residue [active] 911045007619 putative MFS family transporter protein; Provisional; Region: PRK03633 911045007620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045007621 putative substrate translocation pore; other site 911045007622 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 911045007623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045007624 motif II; other site 911045007625 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 911045007626 tetramer (dimer of dimers) interface [polypeptide binding]; other site 911045007627 active site 911045007628 dimer interface [polypeptide binding]; other site 911045007629 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 911045007630 glutathione reductase; Validated; Region: PRK06116 911045007631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 911045007632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045007633 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 911045007634 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 911045007635 putative active site pocket [active] 911045007636 dimerization interface [polypeptide binding]; other site 911045007637 putative catalytic residue [active] 911045007638 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 911045007639 Response regulator receiver domain; Region: Response_reg; pfam00072 911045007640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045007641 active site 911045007642 phosphorylation site [posttranslational modification] 911045007643 intermolecular recognition site; other site 911045007644 dimerization interface [polypeptide binding]; other site 911045007645 NAD synthetase; Provisional; Region: PRK13981 911045007646 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 911045007647 multimer interface [polypeptide binding]; other site 911045007648 active site 911045007649 catalytic triad [active] 911045007650 protein interface 1 [polypeptide binding]; other site 911045007651 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 911045007652 homodimer interface [polypeptide binding]; other site 911045007653 NAD binding pocket [chemical binding]; other site 911045007654 ATP binding pocket [chemical binding]; other site 911045007655 Mg binding site [ion binding]; other site 911045007656 active-site loop [active] 911045007657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045007658 putative substrate translocation pore; other site 911045007659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045007660 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 911045007661 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045007662 active site 911045007663 HIGH motif; other site 911045007664 nucleotide binding site [chemical binding]; other site 911045007665 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 911045007666 active site 911045007667 KMSKS motif; other site 911045007668 hypothetical protein; Provisional; Region: PRK10756 911045007669 CreA protein; Region: CreA; pfam05981 911045007670 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 911045007671 Beta-lactamase; Region: Beta-lactamase; pfam00144 911045007672 murein L,D-transpeptidase; Provisional; Region: PRK10594 911045007673 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 911045007674 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 911045007675 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 911045007676 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 911045007677 active site 911045007678 HIGH motif; other site 911045007679 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 911045007680 KMSKS motif; other site 911045007681 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 911045007682 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 911045007683 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 911045007684 active site 911045007685 catalytic residues [active] 911045007686 metal binding site [ion binding]; metal-binding site 911045007687 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 911045007688 Predicted permeases [General function prediction only]; Region: RarD; COG2962 911045007689 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 911045007690 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 911045007691 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045007692 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 911045007693 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 911045007694 Walker A/P-loop; other site 911045007695 ATP binding site [chemical binding]; other site 911045007696 Q-loop/lid; other site 911045007697 ABC transporter signature motif; other site 911045007698 Walker B; other site 911045007699 D-loop; other site 911045007700 H-loop/switch region; other site 911045007701 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 911045007702 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 911045007703 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 911045007704 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 911045007705 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045007706 Protein export membrane protein; Region: SecD_SecF; cl14618 911045007707 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045007708 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045007709 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045007710 Predicted transcriptional regulators [Transcription]; Region: COG1695 911045007711 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 911045007712 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 911045007713 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 911045007714 active site 911045007715 catalytic site [active] 911045007716 tetramer interface [polypeptide binding]; other site 911045007717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 911045007718 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 911045007719 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045007720 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045007721 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045007722 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045007723 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 911045007724 active site 911045007725 tetramer interface [polypeptide binding]; other site 911045007726 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 911045007727 active site 911045007728 Zn binding site [ion binding]; other site 911045007729 C factor cell-cell signaling protein; Provisional; Region: PRK09009 911045007730 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 911045007731 NADP binding site [chemical binding]; other site 911045007732 homodimer interface [polypeptide binding]; other site 911045007733 active site 911045007734 exopolyphosphatase; Region: exo_poly_only; TIGR03706 911045007735 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 911045007736 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 911045007737 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 911045007738 putative transporter; Provisional; Region: PRK10504 911045007739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045007740 putative substrate translocation pore; other site 911045007741 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 911045007742 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 911045007743 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 911045007744 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 911045007745 active site 911045007746 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; pfam09857 911045007747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045007748 Coenzyme A binding pocket [chemical binding]; other site 911045007749 Cache domain; Region: Cache_1; pfam02743 911045007750 HAMP domain; Region: HAMP; pfam00672 911045007751 dimerization interface [polypeptide binding]; other site 911045007752 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045007753 dimer interface [polypeptide binding]; other site 911045007754 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 911045007755 putative CheW interface [polypeptide binding]; other site 911045007756 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 911045007757 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 911045007758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045007759 binding surface 911045007760 TPR motif; other site 911045007761 TPR repeat; Region: TPR_11; pfam13414 911045007762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045007763 TPR motif; other site 911045007764 binding surface 911045007765 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045007766 MarR family; Region: MarR; pfam01047 911045007767 GMP synthase; Reviewed; Region: guaA; PRK00074 911045007768 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 911045007769 AMP/PPi binding site [chemical binding]; other site 911045007770 candidate oxyanion hole; other site 911045007771 catalytic triad [active] 911045007772 potential glutamine specificity residues [chemical binding]; other site 911045007773 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 911045007774 ATP Binding subdomain [chemical binding]; other site 911045007775 Ligand Binding sites [chemical binding]; other site 911045007776 Dimerization subdomain; other site 911045007777 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 911045007778 PilZ domain; Region: PilZ; cl01260 911045007779 NnrU protein; Region: NnrU; pfam07298 911045007780 NnrU protein; Region: NnrU; pfam07298 911045007781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 911045007782 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 911045007783 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 911045007784 Trp docking motif [polypeptide binding]; other site 911045007785 active site 911045007786 PQQ-like domain; Region: PQQ_2; pfam13360 911045007787 GTP-binding protein Der; Reviewed; Region: PRK00093 911045007788 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 911045007789 G1 box; other site 911045007790 GTP/Mg2+ binding site [chemical binding]; other site 911045007791 Switch I region; other site 911045007792 G2 box; other site 911045007793 Switch II region; other site 911045007794 G3 box; other site 911045007795 G4 box; other site 911045007796 G5 box; other site 911045007797 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 911045007798 G1 box; other site 911045007799 GTP/Mg2+ binding site [chemical binding]; other site 911045007800 Switch I region; other site 911045007801 G2 box; other site 911045007802 G3 box; other site 911045007803 Switch II region; other site 911045007804 G4 box; other site 911045007805 G5 box; other site 911045007806 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 911045007807 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 911045007808 active site 911045007809 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 911045007810 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 911045007811 classical (c) SDRs; Region: SDR_c; cd05233 911045007812 NAD(P) binding site [chemical binding]; other site 911045007813 active site 911045007814 amidophosphoribosyltransferase; Provisional; Region: PRK09123 911045007815 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 911045007816 active site 911045007817 tetramer interface [polypeptide binding]; other site 911045007818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045007819 active site 911045007820 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 911045007821 Colicin V production protein; Region: Colicin_V; pfam02674 911045007822 DNA repair protein RadA; Provisional; Region: PRK11823 911045007823 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 911045007824 Walker A motif; other site 911045007825 ATP binding site [chemical binding]; other site 911045007826 Walker B motif; other site 911045007827 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 911045007828 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 911045007829 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 911045007830 active site 911045007831 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045007832 dimer interface [polypeptide binding]; other site 911045007833 substrate binding site [chemical binding]; other site 911045007834 catalytic residues [active] 911045007835 replicative DNA helicase; Provisional; Region: PRK09165 911045007836 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 911045007837 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 911045007838 Walker A motif; other site 911045007839 ATP binding site [chemical binding]; other site 911045007840 Walker B motif; other site 911045007841 DNA binding loops [nucleotide binding] 911045007842 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 911045007843 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 911045007844 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 911045007845 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 911045007846 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 911045007847 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 911045007848 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 911045007849 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 911045007850 NAD(P) binding site [chemical binding]; other site 911045007851 homotetramer interface [polypeptide binding]; other site 911045007852 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 911045007853 homodimer interface [polypeptide binding]; other site 911045007854 active site 911045007855 acyl carrier protein; Provisional; Region: acpP; PRK00982 911045007856 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 911045007857 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 911045007858 dimer interface [polypeptide binding]; other site 911045007859 active site 911045007860 YceG-like family; Region: YceG; pfam02618 911045007861 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 911045007862 dimerization interface [polypeptide binding]; other site 911045007863 hypothetical protein; Provisional; Region: PRK11820 911045007864 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 911045007865 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 911045007866 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 911045007867 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 911045007868 catalytic site [active] 911045007869 G-X2-G-X-G-K; other site 911045007870 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 911045007871 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 911045007872 Multicopper oxidase; Region: Cu-oxidase; pfam00394 911045007873 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 911045007874 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 911045007875 putative active site [active] 911045007876 catalytic triad [active] 911045007877 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 911045007878 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 911045007879 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 911045007880 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 911045007881 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 911045007882 SurA N-terminal domain; Region: SurA_N; pfam09312 911045007883 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 911045007884 OstA-like protein; Region: OstA; cl00844 911045007885 Organic solvent tolerance protein; Region: OstA_C; pfam04453 911045007886 Predicted permeases [General function prediction only]; Region: COG0795 911045007887 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 911045007888 Predicted permeases [General function prediction only]; Region: COG0795 911045007889 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 911045007890 multifunctional aminopeptidase A; Provisional; Region: PRK00913 911045007891 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 911045007892 interface (dimer of trimers) [polypeptide binding]; other site 911045007893 Substrate-binding/catalytic site; other site 911045007894 Zn-binding sites [ion binding]; other site 911045007895 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 911045007896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045007897 S-adenosylmethionine binding site [chemical binding]; other site 911045007898 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 911045007899 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 911045007900 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 911045007901 ABC transporter; Region: ABC_tran_2; pfam12848 911045007902 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 911045007903 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045007904 EamA-like transporter family; Region: EamA; pfam00892 911045007905 EamA-like transporter family; Region: EamA; pfam00892 911045007906 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 911045007907 synthetase active site [active] 911045007908 NTP binding site [chemical binding]; other site 911045007909 metal binding site [ion binding]; metal-binding site 911045007910 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 911045007911 Predicted membrane protein [Function unknown]; Region: COG1288 911045007912 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 911045007913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 911045007914 DinB superfamily; Region: DinB_2; pfam12867 911045007915 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 911045007916 active site 911045007917 multimer interface [polypeptide binding]; other site 911045007918 Domain of unknown function (DUF336); Region: DUF336; pfam03928 911045007919 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 911045007920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045007922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045007924 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 911045007925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045007927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045007929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045007931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045007933 SnoaL-like domain; Region: SnoaL_2; pfam12680 911045007934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045007935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045007936 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 911045007937 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 911045007938 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 911045007939 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 911045007940 putative [4Fe-4S] binding site [ion binding]; other site 911045007941 putative molybdopterin cofactor binding site [chemical binding]; other site 911045007942 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 911045007943 putative molybdopterin cofactor binding site; other site 911045007944 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 911045007945 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 911045007946 active site 911045007947 substrate binding site [chemical binding]; other site 911045007948 cosubstrate binding site; other site 911045007949 catalytic site [active] 911045007950 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 911045007951 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 911045007952 dimerization interface [polypeptide binding]; other site 911045007953 putative ATP binding site [chemical binding]; other site 911045007954 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 911045007955 Domain of unknown function DUF20; Region: UPF0118; pfam01594 911045007956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 911045007957 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 911045007958 polyphosphate kinase; Provisional; Region: PRK05443 911045007959 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 911045007960 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 911045007961 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 911045007962 putative domain interface [polypeptide binding]; other site 911045007963 putative active site [active] 911045007964 catalytic site [active] 911045007965 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 911045007966 putative domain interface [polypeptide binding]; other site 911045007967 putative active site [active] 911045007968 catalytic site [active] 911045007969 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 911045007970 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 911045007971 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 911045007972 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 911045007973 catalytic site [active] 911045007974 putative active site [active] 911045007975 putative substrate binding site [chemical binding]; other site 911045007976 HRDC domain; Region: HRDC; pfam00570 911045007977 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 911045007978 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 911045007979 dimer interface [polypeptide binding]; other site 911045007980 anticodon binding site; other site 911045007981 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 911045007982 homodimer interface [polypeptide binding]; other site 911045007983 motif 1; other site 911045007984 active site 911045007985 motif 2; other site 911045007986 GAD domain; Region: GAD; pfam02938 911045007987 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 911045007988 active site 911045007989 motif 3; other site 911045007990 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 911045007991 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045007992 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 911045007993 Walker A/P-loop; other site 911045007994 ATP binding site [chemical binding]; other site 911045007995 Q-loop/lid; other site 911045007996 ABC transporter signature motif; other site 911045007997 Walker B; other site 911045007998 D-loop; other site 911045007999 H-loop/switch region; other site 911045008000 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045008001 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045008002 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 911045008003 FAD binding pocket [chemical binding]; other site 911045008004 FAD binding motif [chemical binding]; other site 911045008005 phosphate binding motif [ion binding]; other site 911045008006 beta-alpha-beta structure motif; other site 911045008007 NAD binding pocket [chemical binding]; other site 911045008008 recombination regulator RecX; Reviewed; Region: recX; PRK00117 911045008009 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 911045008010 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 911045008011 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 911045008012 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 911045008013 Potassium binding sites [ion binding]; other site 911045008014 Cesium cation binding sites [ion binding]; other site 911045008015 EamA-like transporter family; Region: EamA; pfam00892 911045008016 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 911045008017 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045008018 N-terminal plug; other site 911045008019 ligand-binding site [chemical binding]; other site 911045008020 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 911045008021 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 911045008022 intersubunit interface [polypeptide binding]; other site 911045008023 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 911045008024 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 911045008025 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045008026 ABC-ATPase subunit interface; other site 911045008027 dimer interface [polypeptide binding]; other site 911045008028 putative PBP binding regions; other site 911045008029 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 911045008030 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045008031 Walker A/P-loop; other site 911045008032 ATP binding site [chemical binding]; other site 911045008033 Q-loop/lid; other site 911045008034 ABC transporter signature motif; other site 911045008035 Walker B; other site 911045008036 D-loop; other site 911045008037 H-loop/switch region; other site 911045008038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045008039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045008040 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 911045008041 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 911045008042 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 911045008043 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 911045008044 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 911045008045 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 911045008046 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 911045008047 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 911045008048 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 911045008049 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 911045008050 phosphate binding site [ion binding]; other site 911045008051 dimer interface [polypeptide binding]; other site 911045008052 substrate binding site [chemical binding]; other site 911045008053 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551 911045008054 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045008055 FeS/SAM binding site; other site 911045008056 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045008057 FeS/SAM binding site; other site 911045008058 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 911045008059 allantoate amidohydrolase; Reviewed; Region: PRK09290 911045008060 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 911045008061 active site 911045008062 metal binding site [ion binding]; metal-binding site 911045008063 dimer interface [polypeptide binding]; other site 911045008064 phenylhydantoinase; Validated; Region: PRK08323 911045008065 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 911045008066 tetramer interface [polypeptide binding]; other site 911045008067 active site 911045008068 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 911045008069 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 911045008070 Na binding site [ion binding]; other site 911045008071 putative substrate binding site [chemical binding]; other site 911045008072 Uncharacterized conserved protein [Function unknown]; Region: COG5470 911045008073 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 911045008074 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 911045008075 acyl-activating enzyme (AAE) consensus motif; other site 911045008076 putative AMP binding site [chemical binding]; other site 911045008077 putative active site [active] 911045008078 putative CoA binding site [chemical binding]; other site 911045008079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045008080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045008081 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045008082 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045008083 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045008084 DctM-like transporters; Region: DctM; pfam06808 911045008085 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045008086 amidase; Provisional; Region: PRK07487 911045008087 Amidase; Region: Amidase; pfam01425 911045008088 alpha-galactosidase; Provisional; Region: PRK15076 911045008089 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 911045008090 NAD binding site [chemical binding]; other site 911045008091 sugar binding site [chemical binding]; other site 911045008092 divalent metal binding site [ion binding]; other site 911045008093 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 911045008094 dimer interface [polypeptide binding]; other site 911045008095 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 911045008096 classical (c) SDRs; Region: SDR_c; cd05233 911045008097 NAD(P) binding site [chemical binding]; other site 911045008098 active site 911045008099 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 911045008100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045008101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045008102 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045008103 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045008104 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045008105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008106 dimer interface [polypeptide binding]; other site 911045008107 conserved gate region; other site 911045008108 putative PBP binding loops; other site 911045008109 ABC-ATPase subunit interface; other site 911045008110 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045008111 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 911045008112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008113 dimer interface [polypeptide binding]; other site 911045008114 conserved gate region; other site 911045008115 putative PBP binding loops; other site 911045008116 ABC-ATPase subunit interface; other site 911045008117 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 911045008118 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045008119 Walker A/P-loop; other site 911045008120 ATP binding site [chemical binding]; other site 911045008121 Q-loop/lid; other site 911045008122 ABC transporter signature motif; other site 911045008123 Walker B; other site 911045008124 D-loop; other site 911045008125 H-loop/switch region; other site 911045008126 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 911045008127 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045008128 Walker A/P-loop; other site 911045008129 ATP binding site [chemical binding]; other site 911045008130 Q-loop/lid; other site 911045008131 ABC transporter signature motif; other site 911045008132 Walker B; other site 911045008133 D-loop; other site 911045008134 H-loop/switch region; other site 911045008135 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 911045008136 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 911045008137 dimer interface [polypeptide binding]; other site 911045008138 Alkaline phosphatase homologues; Region: alkPPc; smart00098 911045008139 active site 911045008140 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 911045008141 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 911045008142 Zn2+ binding site [ion binding]; other site 911045008143 Mg2+ binding site [ion binding]; other site 911045008144 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045008145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045008146 DNA binding site [nucleotide binding] 911045008147 domain linker motif; other site 911045008148 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045008149 ligand binding site [chemical binding]; other site 911045008150 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045008151 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045008152 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045008153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008154 dimer interface [polypeptide binding]; other site 911045008155 conserved gate region; other site 911045008156 putative PBP binding loops; other site 911045008157 ABC-ATPase subunit interface; other site 911045008158 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045008159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008160 dimer interface [polypeptide binding]; other site 911045008161 conserved gate region; other site 911045008162 putative PBP binding loops; other site 911045008163 ABC-ATPase subunit interface; other site 911045008164 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045008165 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045008166 Walker A/P-loop; other site 911045008167 ATP binding site [chemical binding]; other site 911045008168 Q-loop/lid; other site 911045008169 ABC transporter signature motif; other site 911045008170 Walker B; other site 911045008171 D-loop; other site 911045008172 H-loop/switch region; other site 911045008173 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045008174 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 911045008175 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 911045008176 DNA binding residues [nucleotide binding] 911045008177 dimer interface [polypeptide binding]; other site 911045008178 [2Fe-2S] cluster binding site [ion binding]; other site 911045008179 short chain dehydrogenase; Provisional; Region: PRK07577 911045008180 classical (c) SDRs; Region: SDR_c; cd05233 911045008181 NAD(P) binding site [chemical binding]; other site 911045008182 active site 911045008183 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 911045008184 short chain dehydrogenase; Validated; Region: PRK08264 911045008185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045008186 NAD(P) binding site [chemical binding]; other site 911045008187 active site 911045008188 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 911045008189 lipid-transfer protein; Provisional; Region: PRK07855 911045008190 active site 911045008191 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 911045008192 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 911045008193 acyl-activating enzyme (AAE) consensus motif; other site 911045008194 putative AMP binding site [chemical binding]; other site 911045008195 putative active site [active] 911045008196 putative CoA binding site [chemical binding]; other site 911045008197 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 911045008198 inter-subunit interface; other site 911045008199 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 911045008200 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 911045008201 iron-sulfur cluster [ion binding]; other site 911045008202 [2Fe-2S] cluster binding site [ion binding]; other site 911045008203 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 911045008204 putative alpha subunit interface [polypeptide binding]; other site 911045008205 putative active site [active] 911045008206 putative substrate binding site [chemical binding]; other site 911045008207 Fe binding site [ion binding]; other site 911045008208 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045008209 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 911045008210 FMN-binding pocket [chemical binding]; other site 911045008211 flavin binding motif; other site 911045008212 phosphate binding motif [ion binding]; other site 911045008213 beta-alpha-beta structure motif; other site 911045008214 NAD binding pocket [chemical binding]; other site 911045008215 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045008216 catalytic loop [active] 911045008217 iron binding site [ion binding]; other site 911045008218 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045008219 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045008220 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045008221 DctM-like transporters; Region: DctM; pfam06808 911045008222 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045008223 MarR family; Region: MarR_2; cl17246 911045008224 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045008225 MarR family; Region: MarR_2; cl17246 911045008226 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045008227 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 911045008228 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 911045008229 dimer interface [polypeptide binding]; other site 911045008230 PYR/PP interface [polypeptide binding]; other site 911045008231 TPP binding site [chemical binding]; other site 911045008232 substrate binding site [chemical binding]; other site 911045008233 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 911045008234 TPP-binding site; other site 911045008235 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 911045008236 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 911045008237 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 911045008238 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 911045008239 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 911045008240 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 911045008241 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 911045008242 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045008243 putative catalytic site [active] 911045008244 putative metal binding site [ion binding]; other site 911045008245 putative phosphate binding site [ion binding]; other site 911045008246 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 911045008247 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 911045008248 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 911045008249 hypothetical protein; Provisional; Region: PRK07033 911045008250 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 911045008251 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045008252 ligand binding site [chemical binding]; other site 911045008253 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 911045008254 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 911045008255 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 911045008256 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 911045008257 phosphopeptide binding site; other site 911045008258 PAAR motif; Region: PAAR_motif; cl15808 911045008259 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 911045008260 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 911045008261 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 911045008262 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 911045008263 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 911045008264 Protein of unknown function (DUF877); Region: DUF877; pfam05943 911045008265 Ion transport protein; Region: Ion_trans; pfam00520 911045008266 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 911045008267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045008268 Walker A motif; other site 911045008269 ATP binding site [chemical binding]; other site 911045008270 Walker B motif; other site 911045008271 arginine finger; other site 911045008272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045008273 Walker A motif; other site 911045008274 ATP binding site [chemical binding]; other site 911045008275 Walker B motif; other site 911045008276 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 911045008277 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 911045008278 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 911045008279 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 911045008280 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 911045008281 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 911045008282 ImpE protein; Region: ImpE; pfam07024 911045008283 Protein of unknown function (DUF796); Region: DUF796; pfam05638 911045008284 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 911045008285 Protein of unknown function (DUF877); Region: DUF877; pfam05943 911045008286 Protein of unknown function (DUF770); Region: DUF770; pfam05591 911045008287 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 911045008288 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 911045008289 Cytochrome P450; Region: p450; cl12078 911045008290 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 911045008291 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045008292 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045008293 DNA binding site [nucleotide binding] 911045008294 domain linker motif; other site 911045008295 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045008296 ligand binding site [chemical binding]; other site 911045008297 dimerization interface [polypeptide binding]; other site 911045008298 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045008299 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045008300 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 911045008301 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045008302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008303 dimer interface [polypeptide binding]; other site 911045008304 conserved gate region; other site 911045008305 putative PBP binding loops; other site 911045008306 ABC-ATPase subunit interface; other site 911045008307 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045008308 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 911045008309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008310 dimer interface [polypeptide binding]; other site 911045008311 conserved gate region; other site 911045008312 putative PBP binding loops; other site 911045008313 ABC-ATPase subunit interface; other site 911045008314 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 911045008315 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045008316 Walker A/P-loop; other site 911045008317 ATP binding site [chemical binding]; other site 911045008318 Q-loop/lid; other site 911045008319 ABC transporter signature motif; other site 911045008320 Walker B; other site 911045008321 D-loop; other site 911045008322 H-loop/switch region; other site 911045008323 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 911045008324 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 911045008325 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045008326 Walker A/P-loop; other site 911045008327 ATP binding site [chemical binding]; other site 911045008328 Q-loop/lid; other site 911045008329 ABC transporter signature motif; other site 911045008330 Walker B; other site 911045008331 D-loop; other site 911045008332 H-loop/switch region; other site 911045008333 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 911045008334 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 911045008335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045008336 active site 911045008337 motif I; other site 911045008338 motif II; other site 911045008339 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 911045008340 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 911045008341 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 911045008342 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 911045008343 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 911045008344 NADP binding site [chemical binding]; other site 911045008345 homodimer interface [polypeptide binding]; other site 911045008346 active site 911045008347 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 911045008348 D-ribose pyranase; Provisional; Region: PRK11797 911045008349 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 911045008350 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 911045008351 Walker A/P-loop; other site 911045008352 ATP binding site [chemical binding]; other site 911045008353 Q-loop/lid; other site 911045008354 ABC transporter signature motif; other site 911045008355 Walker B; other site 911045008356 D-loop; other site 911045008357 H-loop/switch region; other site 911045008358 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 911045008359 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045008360 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 911045008361 TM-ABC transporter signature motif; other site 911045008362 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 911045008363 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 911045008364 ligand binding site [chemical binding]; other site 911045008365 dimerization interface [polypeptide binding]; other site 911045008366 transcriptional repressor RbsR; Provisional; Region: PRK10423 911045008367 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045008368 DNA binding site [nucleotide binding] 911045008369 domain linker motif; other site 911045008370 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045008371 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 911045008372 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045008373 substrate binding site [chemical binding]; other site 911045008374 dimer interface [polypeptide binding]; other site 911045008375 ATP binding site [chemical binding]; other site 911045008376 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 911045008377 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 911045008378 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 911045008379 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 911045008380 active site 911045008381 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 911045008382 Ligand Binding Site [chemical binding]; other site 911045008383 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 911045008384 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 911045008385 putative NAD(P) binding site [chemical binding]; other site 911045008386 putative substrate binding site [chemical binding]; other site 911045008387 catalytic Zn binding site [ion binding]; other site 911045008388 structural Zn binding site [ion binding]; other site 911045008389 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 911045008390 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 911045008391 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 911045008392 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 911045008393 FAD binding pocket [chemical binding]; other site 911045008394 FAD binding motif [chemical binding]; other site 911045008395 phosphate binding motif [ion binding]; other site 911045008396 beta-alpha-beta structure motif; other site 911045008397 NAD binding pocket [chemical binding]; other site 911045008398 sensor protein QseC; Provisional; Region: PRK10337 911045008399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 911045008400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045008401 dimer interface [polypeptide binding]; other site 911045008402 phosphorylation site [posttranslational modification] 911045008403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045008404 ATP binding site [chemical binding]; other site 911045008405 Mg2+ binding site [ion binding]; other site 911045008406 G-X-G motif; other site 911045008407 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045008408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045008409 active site 911045008410 phosphorylation site [posttranslational modification] 911045008411 intermolecular recognition site; other site 911045008412 dimerization interface [polypeptide binding]; other site 911045008413 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045008414 DNA binding site [nucleotide binding] 911045008415 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 911045008416 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 911045008417 NADP binding site [chemical binding]; other site 911045008418 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 911045008419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045008420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045008421 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045008422 putative effector binding pocket; other site 911045008423 dimerization interface [polypeptide binding]; other site 911045008424 AAA domain; Region: AAA_33; pfam13671 911045008425 AAA domain; Region: AAA_17; pfam13207 911045008426 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 911045008427 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045008428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045008429 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 911045008430 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045008431 catalytic loop [active] 911045008432 iron binding site [ion binding]; other site 911045008433 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 911045008434 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 911045008435 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045008436 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 911045008437 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045008438 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045008439 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 911045008440 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 911045008441 hypothetical protein; Provisional; Region: PRK07475 911045008442 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 911045008443 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 911045008444 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045008445 DctM-like transporters; Region: DctM; pfam06808 911045008446 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045008447 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 911045008448 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 911045008449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045008450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045008451 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045008452 dimerization interface [polypeptide binding]; other site 911045008453 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 911045008454 Subunit I/III interface [polypeptide binding]; other site 911045008455 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045008456 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045008457 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045008458 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045008459 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045008460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045008461 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 911045008462 dimerization interface [polypeptide binding]; other site 911045008463 substrate binding pocket [chemical binding]; other site 911045008464 BCCT family transporter; Region: BCCT; pfam02028 911045008465 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 911045008466 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 911045008467 putative active site [active] 911045008468 metal binding site [ion binding]; metal-binding site 911045008469 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 911045008470 putative active site [active] 911045008471 catalytic site [active] 911045008472 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045008473 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045008474 DNA binding site [nucleotide binding] 911045008475 domain linker motif; other site 911045008476 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045008477 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045008478 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045008479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008480 dimer interface [polypeptide binding]; other site 911045008481 conserved gate region; other site 911045008482 putative PBP binding loops; other site 911045008483 ABC-ATPase subunit interface; other site 911045008484 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045008485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008486 dimer interface [polypeptide binding]; other site 911045008487 conserved gate region; other site 911045008488 putative PBP binding loops; other site 911045008489 ABC-ATPase subunit interface; other site 911045008490 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 911045008491 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045008492 Walker A/P-loop; other site 911045008493 ATP binding site [chemical binding]; other site 911045008494 Q-loop/lid; other site 911045008495 ABC transporter signature motif; other site 911045008496 Walker B; other site 911045008497 D-loop; other site 911045008498 H-loop/switch region; other site 911045008499 TOBE domain; Region: TOBE_2; pfam08402 911045008500 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 911045008501 active site 911045008502 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 911045008503 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045008504 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045008505 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 911045008506 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 911045008507 Cu(I) binding site [ion binding]; other site 911045008508 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 911045008509 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045008510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045008511 putative DNA binding site [nucleotide binding]; other site 911045008512 putative Zn2+ binding site [ion binding]; other site 911045008513 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045008514 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045008515 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 911045008516 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 911045008517 putative catalytic residue [active] 911045008518 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 911045008519 Chain length determinant protein; Region: Wzz; pfam02706 911045008520 Chain length determinant protein; Region: Wzz; cl15801 911045008521 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045008522 P-loop; other site 911045008523 Magnesium ion binding site [ion binding]; other site 911045008524 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 911045008525 Bacterial sugar transferase; Region: Bac_transf; pfam02397 911045008526 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045008527 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 911045008528 putative ADP-binding pocket [chemical binding]; other site 911045008529 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 911045008530 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 911045008531 SLBB domain; Region: SLBB; pfam10531 911045008532 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 911045008533 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 911045008534 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 911045008535 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 911045008536 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 911045008537 metal binding site [ion binding]; metal-binding site 911045008538 putative dimer interface [polypeptide binding]; other site 911045008539 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 911045008540 Amidinotransferase; Region: Amidinotransf; pfam02274 911045008541 ornithine cyclodeaminase; Validated; Region: PRK07589 911045008542 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 911045008543 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045008544 AsnC family; Region: AsnC_trans_reg; pfam01037 911045008545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045008546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045008547 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045008548 dimerization interface [polypeptide binding]; other site 911045008549 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045008550 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045008551 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045008552 DctM-like transporters; Region: DctM; pfam06808 911045008553 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045008554 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 911045008555 agmatinase; Region: agmatinase; TIGR01230 911045008556 oligomer interface [polypeptide binding]; other site 911045008557 active site 911045008558 Mn binding site [ion binding]; other site 911045008559 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045008560 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045008561 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 911045008562 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045008563 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 911045008564 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 911045008565 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 911045008566 putative active site [active] 911045008567 putative substrate binding site [chemical binding]; other site 911045008568 putative cosubstrate binding site; other site 911045008569 catalytic site [active] 911045008570 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045008571 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 911045008572 conserved cys residue [active] 911045008573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045008574 BCCT family transporter; Region: BCCT; pfam02028 911045008575 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045008576 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 911045008577 FAD binding pocket [chemical binding]; other site 911045008578 FAD binding motif [chemical binding]; other site 911045008579 phosphate binding motif [ion binding]; other site 911045008580 beta-alpha-beta structure motif; other site 911045008581 NAD binding pocket [chemical binding]; other site 911045008582 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 911045008583 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045008584 catalytic loop [active] 911045008585 iron binding site [ion binding]; other site 911045008586 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 911045008587 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 911045008588 [2Fe-2S] cluster binding site [ion binding]; other site 911045008589 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 911045008590 putative alpha subunit interface [polypeptide binding]; other site 911045008591 putative active site [active] 911045008592 putative substrate binding site [chemical binding]; other site 911045008593 Fe binding site [ion binding]; other site 911045008594 Tap, RNA-binding; Region: Tap-RNA_bind; pfam09162 911045008595 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 911045008596 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 911045008597 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 911045008598 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045008599 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 911045008600 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 911045008601 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045008602 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 911045008603 conserved cys residue [active] 911045008604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045008605 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045008606 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 911045008607 putative ligand binding site [chemical binding]; other site 911045008608 HEAT repeats; Region: HEAT_2; pfam13646 911045008609 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045008610 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045008611 TM-ABC transporter signature motif; other site 911045008612 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 911045008613 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045008614 TM-ABC transporter signature motif; other site 911045008615 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 911045008616 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 911045008617 Walker A/P-loop; other site 911045008618 ATP binding site [chemical binding]; other site 911045008619 Q-loop/lid; other site 911045008620 ABC transporter signature motif; other site 911045008621 Walker B; other site 911045008622 D-loop; other site 911045008623 H-loop/switch region; other site 911045008624 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 911045008625 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 911045008626 Walker A/P-loop; other site 911045008627 ATP binding site [chemical binding]; other site 911045008628 Q-loop/lid; other site 911045008629 ABC transporter signature motif; other site 911045008630 Walker B; other site 911045008631 D-loop; other site 911045008632 H-loop/switch region; other site 911045008633 UreD urease accessory protein; Region: UreD; cl00530 911045008634 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 911045008635 alpha-gamma subunit interface [polypeptide binding]; other site 911045008636 beta-gamma subunit interface [polypeptide binding]; other site 911045008637 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cl00533 911045008638 alpha-beta subunit interface [polypeptide binding]; other site 911045008639 urease subunit alpha; Reviewed; Region: ureC; PRK13207 911045008640 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 911045008641 subunit interactions [polypeptide binding]; other site 911045008642 active site 911045008643 flap region; other site 911045008644 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 911045008645 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 911045008646 dimer interface [polypeptide binding]; other site 911045008647 catalytic residues [active] 911045008648 UreF; Region: UreF; pfam01730 911045008649 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 911045008650 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045008651 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045008652 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 911045008653 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 911045008654 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045008655 Phosphotransferase enzyme family; Region: APH; pfam01636 911045008656 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 911045008657 active site 911045008658 substrate binding site [chemical binding]; other site 911045008659 ATP binding site [chemical binding]; other site 911045008660 dimer interface [polypeptide binding]; other site 911045008661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008662 dimer interface [polypeptide binding]; other site 911045008663 conserved gate region; other site 911045008664 ABC-ATPase subunit interface; other site 911045008665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008666 dimer interface [polypeptide binding]; other site 911045008667 conserved gate region; other site 911045008668 putative PBP binding loops; other site 911045008669 ABC-ATPase subunit interface; other site 911045008670 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 911045008671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045008672 Walker A/P-loop; other site 911045008673 ATP binding site [chemical binding]; other site 911045008674 Q-loop/lid; other site 911045008675 ABC transporter signature motif; other site 911045008676 Walker B; other site 911045008677 D-loop; other site 911045008678 H-loop/switch region; other site 911045008679 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 911045008680 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 911045008681 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 911045008682 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 911045008683 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 911045008684 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 911045008685 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045008686 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 911045008687 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 911045008688 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 911045008689 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 911045008690 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 911045008691 Cupin domain; Region: Cupin_2; cl17218 911045008692 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 911045008693 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 911045008694 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 911045008695 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 911045008696 Walker A/P-loop; other site 911045008697 ATP binding site [chemical binding]; other site 911045008698 Q-loop/lid; other site 911045008699 ABC transporter signature motif; other site 911045008700 Walker B; other site 911045008701 D-loop; other site 911045008702 H-loop/switch region; other site 911045008703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045008704 dimer interface [polypeptide binding]; other site 911045008705 conserved gate region; other site 911045008706 putative PBP binding loops; other site 911045008707 ABC-ATPase subunit interface; other site 911045008708 acetolactate synthase; Reviewed; Region: PRK08322 911045008709 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045008710 PYR/PP interface [polypeptide binding]; other site 911045008711 dimer interface [polypeptide binding]; other site 911045008712 TPP binding site [chemical binding]; other site 911045008713 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 911045008714 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 911045008715 TPP-binding site [chemical binding]; other site 911045008716 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 911045008717 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 911045008718 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 911045008719 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 911045008720 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 911045008721 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 911045008722 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 911045008723 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 911045008724 TSCPD domain; Region: TSCPD; pfam12637 911045008725 Response regulator receiver domain; Region: Response_reg; pfam00072 911045008726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045008727 active site 911045008728 phosphorylation site [posttranslational modification] 911045008729 intermolecular recognition site; other site 911045008730 dimerization interface [polypeptide binding]; other site 911045008731 NADH dehydrogenase; Validated; Region: PRK08183 911045008732 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 911045008733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 911045008734 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 911045008735 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 911045008736 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045008737 catalytic residue [active] 911045008738 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 911045008739 putative ABC transporter; Region: ycf24; CHL00085 911045008740 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 911045008741 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 911045008742 Walker A/P-loop; other site 911045008743 ATP binding site [chemical binding]; other site 911045008744 Q-loop/lid; other site 911045008745 ABC transporter signature motif; other site 911045008746 Walker B; other site 911045008747 D-loop; other site 911045008748 H-loop/switch region; other site 911045008749 FeS assembly protein SufD; Region: sufD; TIGR01981 911045008750 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 911045008751 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 911045008752 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 911045008753 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045008754 catalytic residue [active] 911045008755 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 911045008756 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 911045008757 Putative transcription activator [Transcription]; Region: TenA; COG0819 911045008758 TfoX N-terminal domain; Region: TfoX_N; pfam04993 911045008759 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 911045008760 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045008761 metal binding site [ion binding]; metal-binding site 911045008762 active site 911045008763 I-site; other site 911045008764 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 911045008765 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 911045008766 ATP binding site [chemical binding]; other site 911045008767 Mg++ binding site [ion binding]; other site 911045008768 motif III; other site 911045008769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045008770 nucleotide binding region [chemical binding]; other site 911045008771 ATP-binding site [chemical binding]; other site 911045008772 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 911045008773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045008774 ATP binding site [chemical binding]; other site 911045008775 Mg2+ binding site [ion binding]; other site 911045008776 G-X-G motif; other site 911045008777 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 911045008778 anchoring element; other site 911045008779 dimer interface [polypeptide binding]; other site 911045008780 ATP binding site [chemical binding]; other site 911045008781 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 911045008782 active site 911045008783 metal binding site [ion binding]; metal-binding site 911045008784 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 911045008785 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045008786 Sel1-like repeats; Region: SEL1; smart00671 911045008787 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 911045008788 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 911045008789 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045008790 active site 911045008791 Int/Topo IB signature motif; other site 911045008792 DNA binding site [nucleotide binding] 911045008793 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 911045008794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045008795 non-specific DNA binding site [nucleotide binding]; other site 911045008796 salt bridge; other site 911045008797 sequence-specific DNA binding site [nucleotide binding]; other site 911045008798 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 911045008799 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 911045008800 CHC2 zinc finger; Region: zf-CHC2; cl17510 911045008801 Toprim domain; Region: Toprim_3; pfam13362 911045008802 D5 N terminal like; Region: D5_N; pfam08706 911045008803 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 911045008804 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 911045008805 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 911045008806 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 911045008807 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 911045008808 oligomer interface [polypeptide binding]; other site 911045008809 active site residues [active] 911045008810 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 911045008811 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 911045008812 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 911045008813 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 911045008814 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 911045008815 Baseplate J-like protein; Region: Baseplate_J; cl01294 911045008816 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 911045008817 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 911045008818 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 911045008819 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 911045008820 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 911045008821 Phage tail tube protein FII; Region: Phage_tube; pfam04985 911045008822 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 911045008823 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 911045008824 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 911045008825 Phage Tail Protein X; Region: Phage_tail_X; cl02088 911045008826 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 911045008827 Peptidase M15; Region: Peptidase_M15_3; cl01194 911045008828 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 911045008829 Catalytic site; other site 911045008830 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045008831 AAA domain; Region: AAA_21; pfam13304 911045008832 Prophage antirepressor [Transcription]; Region: COG3617 911045008833 BRO family, N-terminal domain; Region: Bro-N; smart01040 911045008834 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045008835 putative catalytic site [active] 911045008836 putative metal binding site [ion binding]; other site 911045008837 putative phosphate binding site [ion binding]; other site 911045008838 biotin synthase; Region: bioB; TIGR00433 911045008839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045008840 FeS/SAM binding site; other site 911045008841 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 911045008842 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 911045008843 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 911045008844 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045008845 catalytic residue [active] 911045008846 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 911045008847 AAA domain; Region: AAA_26; pfam13500 911045008848 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 911045008849 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045008850 inhibitor-cofactor binding pocket; inhibition site 911045008851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045008852 catalytic residue [active] 911045008853 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 911045008854 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 911045008855 dimer interface [polypeptide binding]; other site 911045008856 active site 911045008857 CoA binding pocket [chemical binding]; other site 911045008858 YceI-like domain; Region: YceI; pfam04264 911045008859 Cytochrome c2 [Energy production and conversion]; Region: COG3474 911045008860 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 911045008861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045008862 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045008863 DNA binding residues [nucleotide binding] 911045008864 Transcriptional regulators [Transcription]; Region: MarR; COG1846 911045008865 MarR family; Region: MarR_2; pfam12802 911045008866 MarR family; Region: MarR_2; cl17246 911045008867 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 911045008868 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045008869 N-terminal plug; other site 911045008870 ligand-binding site [chemical binding]; other site 911045008871 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 911045008872 Ferritin-like domain; Region: Ferritin; pfam00210 911045008873 ferroxidase diiron center [ion binding]; other site 911045008874 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045008875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045008876 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 911045008877 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045008878 N-terminal plug; other site 911045008879 ligand-binding site [chemical binding]; other site 911045008880 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 911045008881 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 911045008882 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 911045008883 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 911045008884 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 911045008885 putative ligand binding residues [chemical binding]; other site 911045008886 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 911045008887 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 911045008888 ABC-ATPase subunit interface; other site 911045008889 dimer interface [polypeptide binding]; other site 911045008890 putative PBP binding regions; other site 911045008891 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 911045008892 ABC-ATPase subunit interface; other site 911045008893 dimer interface [polypeptide binding]; other site 911045008894 putative PBP binding regions; other site 911045008895 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 911045008896 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 911045008897 Walker A/P-loop; other site 911045008898 ATP binding site [chemical binding]; other site 911045008899 Q-loop/lid; other site 911045008900 ABC transporter signature motif; other site 911045008901 Walker B; other site 911045008902 D-loop; other site 911045008903 H-loop/switch region; other site 911045008904 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 911045008905 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 911045008906 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 911045008907 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 911045008908 Na binding site [ion binding]; other site 911045008909 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 911045008910 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045008911 ligand binding site [chemical binding]; other site 911045008912 flexible hinge region; other site 911045008913 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 911045008914 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 911045008915 metal binding triad; other site 911045008916 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 911045008917 active site 911045008918 catalytic site [active] 911045008919 substrate binding site [chemical binding]; other site 911045008920 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 911045008921 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045008922 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045008923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045008924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045008925 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045008926 dimerization interface [polypeptide binding]; other site 911045008927 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045008928 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045008929 DctM-like transporters; Region: DctM; pfam06808 911045008930 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045008931 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 911045008932 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 911045008933 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045008934 catalytic residue [active] 911045008935 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 911045008936 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045008937 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 911045008938 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 911045008939 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045008940 Transposase; Region: HTH_Tnp_1; pfam01527 911045008941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 911045008942 Helix-turn-helix domain; Region: HTH_28; pfam13518 911045008943 Winged helix-turn helix; Region: HTH_29; pfam13551 911045008944 Homeodomain-like domain; Region: HTH_32; pfam13565 911045008945 Integrase core domain; Region: rve; pfam00665 911045008946 Integrase core domain; Region: rve_3; pfam13683 911045008947 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 911045008948 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 911045008949 4Fe-4S binding domain; Region: Fer4_5; pfam12801 911045008950 nitrous-oxide reductase; Validated; Region: PRK02888 911045008951 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 911045008952 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 911045008953 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 911045008954 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 911045008955 Walker A/P-loop; other site 911045008956 ATP binding site [chemical binding]; other site 911045008957 Q-loop/lid; other site 911045008958 ABC transporter signature motif; other site 911045008959 Walker B; other site 911045008960 D-loop; other site 911045008961 H-loop/switch region; other site 911045008962 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 911045008963 NosL; Region: NosL; pfam05573 911045008964 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 911045008965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045008966 non-specific DNA binding site [nucleotide binding]; other site 911045008967 salt bridge; other site 911045008968 sequence-specific DNA binding site [nucleotide binding]; other site 911045008969 arginine decarboxylase; Provisional; Region: PRK05354 911045008970 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 911045008971 dimer interface [polypeptide binding]; other site 911045008972 active site 911045008973 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045008974 catalytic residues [active] 911045008975 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 911045008976 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 911045008977 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 911045008978 NAD(P) binding pocket [chemical binding]; other site 911045008979 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 911045008980 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 911045008981 dimer interface [polypeptide binding]; other site 911045008982 active site 911045008983 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045008984 catalytic residues [active] 911045008985 substrate binding site [chemical binding]; other site 911045008986 agmatinase; Region: agmatinase; TIGR01230 911045008987 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 911045008988 putative active site [active] 911045008989 Mn binding site [ion binding]; other site 911045008990 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 911045008991 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 911045008992 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 911045008993 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 911045008994 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 911045008995 thymidylate kinase; Validated; Region: tmk; PRK00698 911045008996 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 911045008997 TMP-binding site; other site 911045008998 ATP-binding site [chemical binding]; other site 911045008999 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 911045009000 DNA polymerase III subunit delta'; Validated; Region: PRK08485 911045009001 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 911045009002 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 911045009003 active site 911045009004 HIGH motif; other site 911045009005 KMSKS motif; other site 911045009006 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 911045009007 tRNA binding surface [nucleotide binding]; other site 911045009008 anticodon binding site; other site 911045009009 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 911045009010 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 911045009011 active site 911045009012 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 911045009013 putative hydrolase; Provisional; Region: PRK02113 911045009014 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 911045009015 hypothetical protein; Provisional; Region: PRK07236 911045009016 hypothetical protein; Provisional; Region: PRK07236 911045009017 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 911045009018 active site 911045009019 FMN binding site [chemical binding]; other site 911045009020 substrate binding site [chemical binding]; other site 911045009021 homotetramer interface [polypeptide binding]; other site 911045009022 catalytic residue [active] 911045009023 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 911045009024 classical (c) SDRs; Region: SDR_c; cd05233 911045009025 NAD(P) binding site [chemical binding]; other site 911045009026 active site 911045009027 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045009028 MarR family; Region: MarR_2; pfam12802 911045009029 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 911045009030 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045009031 substrate binding site [chemical binding]; other site 911045009032 oxyanion hole (OAH) forming residues; other site 911045009033 trimer interface [polypeptide binding]; other site 911045009034 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045009035 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 911045009036 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045009037 active site 911045009038 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 911045009039 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 911045009040 acyl-activating enzyme (AAE) consensus motif; other site 911045009041 AMP binding site [chemical binding]; other site 911045009042 active site 911045009043 CoA binding site [chemical binding]; other site 911045009044 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045009045 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 911045009046 putative ligand binding site [chemical binding]; other site 911045009047 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045009048 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045009049 TM-ABC transporter signature motif; other site 911045009050 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045009051 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045009052 TM-ABC transporter signature motif; other site 911045009053 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045009054 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 911045009055 Walker A/P-loop; other site 911045009056 ATP binding site [chemical binding]; other site 911045009057 Q-loop/lid; other site 911045009058 ABC transporter signature motif; other site 911045009059 Walker B; other site 911045009060 D-loop; other site 911045009061 H-loop/switch region; other site 911045009062 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045009063 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 911045009064 Walker A/P-loop; other site 911045009065 ATP binding site [chemical binding]; other site 911045009066 Q-loop/lid; other site 911045009067 ABC transporter signature motif; other site 911045009068 Walker B; other site 911045009069 D-loop; other site 911045009070 H-loop/switch region; other site 911045009071 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045009072 active site 911045009073 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045009074 homotrimer interaction site [polypeptide binding]; other site 911045009075 putative active site [active] 911045009076 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 911045009077 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 911045009078 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045009079 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045009080 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 911045009081 active site 911045009082 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 911045009083 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 911045009084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045009085 binding surface 911045009086 TPR motif; other site 911045009087 Protein of unknown function, DUF480; Region: DUF480; cl01209 911045009088 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 911045009089 hypothetical protein; Provisional; Region: PRK09936 911045009090 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 911045009091 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 911045009092 active site 911045009093 homodimer interface [polypeptide binding]; other site 911045009094 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 911045009095 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 911045009096 NAD binding site [chemical binding]; other site 911045009097 substrate binding site [chemical binding]; other site 911045009098 catalytic Zn binding site [ion binding]; other site 911045009099 tetramer interface [polypeptide binding]; other site 911045009100 structural Zn binding site [ion binding]; other site 911045009101 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 911045009102 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 911045009103 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 911045009104 phosphate binding site [ion binding]; other site 911045009105 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 911045009106 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 911045009107 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 911045009108 active site 2 [active] 911045009109 active site 1 [active] 911045009110 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 911045009111 active site 2 [active] 911045009112 active site 1 [active] 911045009113 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045009114 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045009115 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 911045009116 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 911045009117 metal binding site [ion binding]; metal-binding site 911045009118 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 911045009119 Protein of unknown function (DUF989); Region: DUF989; pfam06181 911045009120 Predicted membrane protein [Function unknown]; Region: COG3748 911045009121 Cytochrome c; Region: Cytochrom_C; pfam00034 911045009122 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 911045009123 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 911045009124 putative ligand binding site [chemical binding]; other site 911045009125 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045009126 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045009127 TM-ABC transporter signature motif; other site 911045009128 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045009129 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 911045009130 TM-ABC transporter signature motif; other site 911045009131 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 911045009132 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 911045009133 Walker A/P-loop; other site 911045009134 ATP binding site [chemical binding]; other site 911045009135 Q-loop/lid; other site 911045009136 ABC transporter signature motif; other site 911045009137 Walker B; other site 911045009138 D-loop; other site 911045009139 H-loop/switch region; other site 911045009140 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 911045009141 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 911045009142 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 911045009143 XdhC Rossmann domain; Region: XdhC_C; pfam13478 911045009144 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 911045009145 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 911045009146 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045009147 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 911045009148 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045009149 catalytic loop [active] 911045009150 iron binding site [ion binding]; other site 911045009151 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 911045009152 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 911045009153 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 911045009154 active site 911045009155 homotetramer interface [polypeptide binding]; other site 911045009156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045009157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045009158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045009159 dimerization interface [polypeptide binding]; other site 911045009160 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 911045009161 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 911045009162 NADP binding site [chemical binding]; other site 911045009163 dimer interface [polypeptide binding]; other site 911045009164 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 911045009165 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 911045009166 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 911045009167 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 911045009168 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 911045009169 Predicted permeases [General function prediction only]; Region: COG0679 911045009170 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 911045009171 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 911045009172 putative acyl-acceptor binding pocket; other site 911045009173 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 911045009174 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 911045009175 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 911045009176 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 911045009177 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 911045009178 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 911045009179 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 911045009180 acyl-activating enzyme (AAE) consensus motif; other site 911045009181 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 911045009182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045009183 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 911045009184 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 911045009185 catalytic residues [active] 911045009186 enolase; Provisional; Region: eno; PRK00077 911045009187 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 911045009188 dimer interface [polypeptide binding]; other site 911045009189 metal binding site [ion binding]; metal-binding site 911045009190 substrate binding pocket [chemical binding]; other site 911045009191 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 911045009192 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 911045009193 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 911045009194 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 911045009195 CysD dimerization site [polypeptide binding]; other site 911045009196 G1 box; other site 911045009197 putative GEF interaction site [polypeptide binding]; other site 911045009198 GTP/Mg2+ binding site [chemical binding]; other site 911045009199 Switch I region; other site 911045009200 G2 box; other site 911045009201 G3 box; other site 911045009202 Switch II region; other site 911045009203 G4 box; other site 911045009204 G5 box; other site 911045009205 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 911045009206 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 911045009207 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 911045009208 ligand-binding site [chemical binding]; other site 911045009209 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 911045009210 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 911045009211 Active Sites [active] 911045009212 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 911045009213 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 911045009214 active site 911045009215 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 911045009216 active site 911045009217 tetramer interface; other site 911045009218 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045009219 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 911045009220 putative NAD(P) binding site [chemical binding]; other site 911045009221 active site 911045009222 putative substrate binding site [chemical binding]; other site 911045009223 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 911045009224 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 911045009225 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 911045009226 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 911045009227 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 911045009228 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 911045009229 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 911045009230 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 911045009231 active site 911045009232 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 911045009233 active site 911045009234 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 911045009235 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 911045009236 active site 911045009237 (T/H)XGH motif; other site 911045009238 DNA gyrase subunit A; Validated; Region: PRK05560 911045009239 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 911045009240 CAP-like domain; other site 911045009241 active site 911045009242 primary dimer interface [polypeptide binding]; other site 911045009243 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045009244 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045009245 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045009246 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045009247 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 911045009248 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 911045009249 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 911045009250 Cation efflux family; Region: Cation_efflux; pfam01545 911045009251 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 911045009252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045009253 NAD(P) binding site [chemical binding]; other site 911045009254 active site 911045009255 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 911045009256 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 911045009257 DNA-binding site [nucleotide binding]; DNA binding site 911045009258 RNA-binding motif; other site 911045009259 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 911045009260 DNA-binding site [nucleotide binding]; DNA binding site 911045009261 RNA-binding motif; other site 911045009262 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045009263 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 911045009264 dimer interface [polypeptide binding]; other site 911045009265 active site 911045009266 metal binding site [ion binding]; metal-binding site 911045009267 glutathione binding site [chemical binding]; other site 911045009268 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 911045009269 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 911045009270 dimer interface [polypeptide binding]; other site 911045009271 ssDNA binding site [nucleotide binding]; other site 911045009272 tetramer (dimer of dimers) interface [polypeptide binding]; other site 911045009273 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 911045009274 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 911045009275 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 911045009276 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 911045009277 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 911045009278 Glucose inhibited division protein A; Region: GIDA; pfam01134 911045009279 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 911045009280 substrate binding pocket [chemical binding]; other site 911045009281 substrate-Mg2+ binding site; other site 911045009282 aspartate-rich region 1; other site 911045009283 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 911045009284 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 911045009285 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 911045009286 Protein export membrane protein; Region: SecD_SecF; pfam02355 911045009287 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 911045009288 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 911045009289 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 911045009290 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 911045009291 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 911045009292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045009293 Walker A motif; other site 911045009294 ATP binding site [chemical binding]; other site 911045009295 Walker B motif; other site 911045009296 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 911045009297 cell division protein DamX; Validated; Region: PRK10905 911045009298 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 911045009299 Peptidase family M23; Region: Peptidase_M23; pfam01551 911045009300 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 911045009301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045009302 S-adenosylmethionine binding site [chemical binding]; other site 911045009303 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 911045009304 seryl-tRNA synthetase; Provisional; Region: PRK05431 911045009305 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 911045009306 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 911045009307 dimer interface [polypeptide binding]; other site 911045009308 active site 911045009309 motif 1; other site 911045009310 motif 2; other site 911045009311 motif 3; other site 911045009312 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 911045009313 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 911045009314 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 911045009315 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045009316 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 911045009317 Walker A/P-loop; other site 911045009318 ATP binding site [chemical binding]; other site 911045009319 Q-loop/lid; other site 911045009320 ABC transporter signature motif; other site 911045009321 Walker B; other site 911045009322 D-loop; other site 911045009323 H-loop/switch region; other site 911045009324 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 911045009325 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 911045009326 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 911045009327 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 911045009328 Sporulation related domain; Region: SPOR; pfam05036 911045009329 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 911045009330 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 911045009331 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 911045009332 active site 911045009333 HIGH motif; other site 911045009334 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 911045009335 KMSK motif region; other site 911045009336 tRNA binding surface [nucleotide binding]; other site 911045009337 DALR anticodon binding domain; Region: DALR_1; smart00836 911045009338 anticodon binding site; other site 911045009339 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 911045009340 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 911045009341 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 911045009342 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 911045009343 putative catalytic site [active] 911045009344 putative phosphate binding site [ion binding]; other site 911045009345 active site 911045009346 metal binding site A [ion binding]; metal-binding site 911045009347 DNA binding site [nucleotide binding] 911045009348 putative AP binding site [nucleotide binding]; other site 911045009349 putative metal binding site B [ion binding]; other site 911045009350 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045009351 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 911045009352 active site 911045009353 catalytic tetrad [active] 911045009354 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 911045009355 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 911045009356 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 911045009357 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045009358 catalytic residue [active] 911045009359 Pyruvate formate lyase 1; Region: PFL1; cd01678 911045009360 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 911045009361 coenzyme A binding site [chemical binding]; other site 911045009362 active site 911045009363 catalytic residues [active] 911045009364 glycine loop; other site 911045009365 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 911045009366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045009367 FeS/SAM binding site; other site 911045009368 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 911045009369 hypothetical protein; Provisional; Region: PRK07483 911045009370 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045009371 inhibitor-cofactor binding pocket; inhibition site 911045009372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045009373 catalytic residue [active] 911045009374 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045009375 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 911045009376 TetR family transcriptional regulator; Provisional; Region: PRK14996 911045009377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045009378 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 911045009379 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 911045009380 Dehydroquinase class II; Region: DHquinase_II; pfam01220 911045009381 active site 911045009382 trimer interface [polypeptide binding]; other site 911045009383 dimer interface [polypeptide binding]; other site 911045009384 Methyltransferase domain; Region: Methyltransf_23; pfam13489 911045009385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045009386 S-adenosylmethionine binding site [chemical binding]; other site 911045009387 hypothetical protein; Provisional; Region: PRK09256 911045009388 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 911045009389 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 911045009390 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045009391 inhibitor-cofactor binding pocket; inhibition site 911045009392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045009393 catalytic residue [active] 911045009394 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 911045009395 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 911045009396 homodimer interface [polypeptide binding]; other site 911045009397 metal binding site [ion binding]; metal-binding site 911045009398 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 911045009399 homodimer interface [polypeptide binding]; other site 911045009400 active site 911045009401 putative chemical substrate binding site [chemical binding]; other site 911045009402 metal binding site [ion binding]; metal-binding site 911045009403 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 911045009404 putative active site [active] 911045009405 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 911045009406 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 911045009407 HflX GTPase family; Region: HflX; cd01878 911045009408 G1 box; other site 911045009409 GTP/Mg2+ binding site [chemical binding]; other site 911045009410 Switch I region; other site 911045009411 G2 box; other site 911045009412 G3 box; other site 911045009413 Switch II region; other site 911045009414 G4 box; other site 911045009415 G5 box; other site 911045009416 bacterial Hfq-like; Region: Hfq; cd01716 911045009417 hexamer interface [polypeptide binding]; other site 911045009418 Sm1 motif; other site 911045009419 RNA binding site [nucleotide binding]; other site 911045009420 Sm2 motif; other site 911045009421 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 911045009422 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 911045009423 homodimer interface [polypeptide binding]; other site 911045009424 substrate-cofactor binding pocket; other site 911045009425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045009426 catalytic residue [active] 911045009427 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 911045009428 TrkA-N domain; Region: TrkA_N; pfam02254 911045009429 TrkA-C domain; Region: TrkA_C; pfam02080 911045009430 TrkA-N domain; Region: TrkA_N; pfam02254 911045009431 TrkA-C domain; Region: TrkA_C; pfam02080 911045009432 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 911045009433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045009434 active site 911045009435 phosphorylation site [posttranslational modification] 911045009436 intermolecular recognition site; other site 911045009437 dimerization interface [polypeptide binding]; other site 911045009438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045009439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045009440 Walker A motif; other site 911045009441 Walker A/P-loop; other site 911045009442 ATP binding site [chemical binding]; other site 911045009443 ATP binding site [chemical binding]; other site 911045009444 Walker B motif; other site 911045009445 arginine finger; other site 911045009446 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 911045009447 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 911045009448 HAMP domain; Region: HAMP; pfam00672 911045009449 dimerization interface [polypeptide binding]; other site 911045009450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045009451 dimer interface [polypeptide binding]; other site 911045009452 phosphorylation site [posttranslational modification] 911045009453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045009454 ATP binding site [chemical binding]; other site 911045009455 Mg2+ binding site [ion binding]; other site 911045009456 G-X-G motif; other site 911045009457 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 911045009458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045009459 active site 911045009460 phosphorylation site [posttranslational modification] 911045009461 intermolecular recognition site; other site 911045009462 dimerization interface [polypeptide binding]; other site 911045009463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045009464 Walker A motif; other site 911045009465 ATP binding site [chemical binding]; other site 911045009466 Walker B motif; other site 911045009467 arginine finger; other site 911045009468 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 911045009469 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 911045009470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045009471 dimer interface [polypeptide binding]; other site 911045009472 phosphorylation site [posttranslational modification] 911045009473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045009474 ATP binding site [chemical binding]; other site 911045009475 Mg2+ binding site [ion binding]; other site 911045009476 G-X-G motif; other site 911045009477 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 911045009478 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 911045009479 FMN binding site [chemical binding]; other site 911045009480 active site 911045009481 catalytic residues [active] 911045009482 substrate binding site [chemical binding]; other site 911045009483 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 911045009484 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 911045009485 substrate binding site; other site 911045009486 dimer interface; other site 911045009487 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 911045009488 homotrimer interaction site [polypeptide binding]; other site 911045009489 zinc binding site [ion binding]; other site 911045009490 CDP-binding sites; other site 911045009491 Competence-damaged protein; Region: CinA; pfam02464 911045009492 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 911045009493 nudix motif; other site 911045009494 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 911045009495 putative coenzyme Q binding site [chemical binding]; other site 911045009496 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045009497 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 911045009498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045009499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045009500 enoyl-CoA hydratase; Provisional; Region: PRK05980 911045009501 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045009502 substrate binding site [chemical binding]; other site 911045009503 oxyanion hole (OAH) forming residues; other site 911045009504 trimer interface [polypeptide binding]; other site 911045009505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045009506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045009507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045009508 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 911045009509 EamA-like transporter family; Region: EamA; pfam00892 911045009510 lipoyl synthase; Provisional; Region: PRK05481 911045009511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045009512 FeS/SAM binding site; other site 911045009513 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 911045009514 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 911045009515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045009516 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 911045009517 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 911045009518 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 911045009519 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 911045009520 E3 interaction surface; other site 911045009521 lipoyl attachment site [posttranslational modification]; other site 911045009522 e3 binding domain; Region: E3_binding; pfam02817 911045009523 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 911045009524 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 911045009525 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 911045009526 E3 interaction surface; other site 911045009527 lipoyl attachment site [posttranslational modification]; other site 911045009528 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 911045009529 alpha subunit interface [polypeptide binding]; other site 911045009530 TPP binding site [chemical binding]; other site 911045009531 heterodimer interface [polypeptide binding]; other site 911045009532 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 911045009533 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 911045009534 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 911045009535 tetramer interface [polypeptide binding]; other site 911045009536 TPP-binding site [chemical binding]; other site 911045009537 heterodimer interface [polypeptide binding]; other site 911045009538 phosphorylation loop region [posttranslational modification] 911045009539 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 911045009540 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 911045009541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045009542 ATP binding site [chemical binding]; other site 911045009543 putative Mg++ binding site [ion binding]; other site 911045009544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045009545 nucleotide binding region [chemical binding]; other site 911045009546 ATP-binding site [chemical binding]; other site 911045009547 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 911045009548 Uncharacterized conserved protein [Function unknown]; Region: COG2938 911045009549 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 911045009550 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 911045009551 generic binding surface II; other site 911045009552 ssDNA binding site; other site 911045009553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045009554 ATP binding site [chemical binding]; other site 911045009555 putative Mg++ binding site [ion binding]; other site 911045009556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045009557 nucleotide binding region [chemical binding]; other site 911045009558 ATP-binding site [chemical binding]; other site 911045009559 Uncharacterized conserved protein [Function unknown]; Region: COG2928 911045009560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 911045009561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045009562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045009563 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045009564 putative effector binding pocket; other site 911045009565 dimerization interface [polypeptide binding]; other site 911045009566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045009567 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045009568 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 911045009569 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 911045009570 dimer interface [polypeptide binding]; other site 911045009571 substrate binding pocket (H-site) [chemical binding]; other site 911045009572 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 911045009573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045009574 putative substrate translocation pore; other site 911045009575 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 911045009576 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 911045009577 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 911045009578 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 911045009579 Autotransporter beta-domain; Region: Autotransporter; pfam03797 911045009580 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 911045009581 putative peroxiredoxin; Provisional; Region: PRK13190 911045009582 decamer (pentamer of dimers) interface [polypeptide binding]; other site 911045009583 catalytic triad [active] 911045009584 dimer interface [polypeptide binding]; other site 911045009585 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 911045009586 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 911045009587 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 911045009588 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 911045009589 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 911045009590 Beta-lactamase; Region: Beta-lactamase; pfam00144 911045009591 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045009592 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 911045009593 active site 911045009594 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009595 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 911045009596 FtsX-like permease family; Region: FtsX; pfam02687 911045009597 FtsX-like permease family; Region: FtsX; pfam02687 911045009598 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 911045009599 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 911045009600 Walker A/P-loop; other site 911045009601 ATP binding site [chemical binding]; other site 911045009602 Q-loop/lid; other site 911045009603 ABC transporter signature motif; other site 911045009604 Walker B; other site 911045009605 D-loop; other site 911045009606 H-loop/switch region; other site 911045009607 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045009608 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045009609 Condensation domain; Region: Condensation; pfam00668 911045009610 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 911045009611 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 911045009612 acyl-activating enzyme (AAE) consensus motif; other site 911045009613 AMP binding site [chemical binding]; other site 911045009614 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009615 Condensation domain; Region: Condensation; pfam00668 911045009616 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 911045009617 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045009618 amidase; Provisional; Region: PRK06170 911045009619 Amidase; Region: Amidase; cl11426 911045009620 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045009621 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 911045009622 active site 911045009623 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009624 Condensation domain; Region: Condensation; pfam00668 911045009625 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 911045009626 Nonribosomal peptide synthase; Region: NRPS; pfam08415 911045009627 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 911045009628 acyl-activating enzyme (AAE) consensus motif; other site 911045009629 AMP binding site [chemical binding]; other site 911045009630 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 911045009631 putative FMN binding site [chemical binding]; other site 911045009632 NADPH bind site [chemical binding]; other site 911045009633 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 911045009634 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009635 Condensation domain; Region: Condensation; pfam00668 911045009636 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 911045009637 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 911045009638 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 911045009639 acyl-activating enzyme (AAE) consensus motif; other site 911045009640 AMP binding site [chemical binding]; other site 911045009641 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009642 Condensation domain; Region: Condensation; pfam00668 911045009643 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 911045009644 Nonribosomal peptide synthase; Region: NRPS; pfam08415 911045009645 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 911045009646 acyl-activating enzyme (AAE) consensus motif; other site 911045009647 AMP binding site [chemical binding]; other site 911045009648 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009649 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045009650 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 911045009651 active site 911045009652 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 911045009653 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 911045009654 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009655 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 911045009656 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 911045009657 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 911045009658 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 911045009659 acyl-activating enzyme (AAE) consensus motif; other site 911045009660 AMP binding site [chemical binding]; other site 911045009661 Condensation domain; Region: Condensation; pfam00668 911045009662 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 911045009663 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 911045009664 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 911045009665 acyl-activating enzyme (AAE) consensus motif; other site 911045009666 AMP binding site [chemical binding]; other site 911045009667 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009668 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045009669 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045009670 active site 911045009671 Phosphopantetheine attachment site; Region: PP-binding; cl09936 911045009672 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 911045009673 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 911045009674 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045009675 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 911045009676 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045009677 active site 911045009678 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009679 Condensation domain; Region: Condensation; pfam00668 911045009680 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 911045009681 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 911045009682 acyl-activating enzyme (AAE) consensus motif; other site 911045009683 AMP binding site [chemical binding]; other site 911045009684 active site 911045009685 CoA binding site [chemical binding]; other site 911045009686 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009687 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 911045009688 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045009689 active site 911045009690 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 911045009691 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 911045009692 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 911045009693 NADP binding site [chemical binding]; other site 911045009694 active site 911045009695 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 911045009696 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 911045009697 Enoylreductase; Region: PKS_ER; smart00829 911045009698 NAD(P) binding site [chemical binding]; other site 911045009699 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 911045009700 Transposase; Region: HTH_Tnp_1; cl17663 911045009701 Winged helix-turn helix; Region: HTH_29; pfam13551 911045009702 Homeodomain-like domain; Region: HTH_32; pfam13565 911045009703 Integrase core domain; Region: rve; pfam00665 911045009704 Integrase core domain; Region: rve_3; pfam13683 911045009705 TniQ; Region: TniQ; pfam06527 911045009706 Integrase core domain; Region: rve; pfam00665 911045009707 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 911045009708 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 911045009709 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 911045009710 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 911045009711 glutaminase active site [active] 911045009712 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 911045009713 dimer interface [polypeptide binding]; other site 911045009714 active site 911045009715 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 911045009716 dimer interface [polypeptide binding]; other site 911045009717 active site 911045009718 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 911045009719 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 911045009720 Substrate binding site; other site 911045009721 Mg++ binding site; other site 911045009722 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 911045009723 active site 911045009724 substrate binding site [chemical binding]; other site 911045009725 CoA binding site [chemical binding]; other site 911045009726 EamA-like transporter family; Region: EamA; pfam00892 911045009727 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045009728 EamA-like transporter family; Region: EamA; cl17759 911045009729 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 911045009730 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 911045009731 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 911045009732 Ligand Binding Site [chemical binding]; other site 911045009733 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 911045009734 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045009735 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 911045009736 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 911045009737 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 911045009738 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 911045009739 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 911045009740 Ferritin-like; Region: Ferritin-like; pfam12902 911045009741 hypothetical protein; Provisional; Region: PRK05409 911045009742 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 911045009743 Transposase; Region: HTH_Tnp_1; pfam01527 911045009744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 911045009745 Helix-turn-helix domain; Region: HTH_28; pfam13518 911045009746 Winged helix-turn helix; Region: HTH_29; pfam13551 911045009747 Homeodomain-like domain; Region: HTH_32; pfam13565 911045009748 Integrase core domain; Region: rve; pfam00665 911045009749 Integrase core domain; Region: rve_3; pfam13683 911045009750 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045009751 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 911045009752 hypothetical protein; Provisional; Region: PRK07208 911045009753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 911045009754 UDP-galactopyranose mutase; Region: GLF; pfam03275 911045009755 Iron permease FTR1 family; Region: FTR1; cl00475 911045009756 Uncharacterized conserved protein [Function unknown]; Region: COG3391 911045009757 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 911045009758 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 911045009759 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 911045009760 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 911045009761 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 911045009762 dimer interface [polypeptide binding]; other site 911045009763 active site 911045009764 metal binding site [ion binding]; metal-binding site 911045009765 ornithine cyclodeaminase; Validated; Region: PRK06141 911045009766 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 911045009767 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 911045009768 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045009769 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045009770 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045009771 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 911045009772 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 911045009773 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045009774 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 911045009775 Walker A/P-loop; other site 911045009776 ATP binding site [chemical binding]; other site 911045009777 Q-loop/lid; other site 911045009778 ABC transporter signature motif; other site 911045009779 Walker B; other site 911045009780 D-loop; other site 911045009781 H-loop/switch region; other site 911045009782 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 911045009783 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045009784 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 911045009785 CTP synthetase; Validated; Region: pyrG; PRK05380 911045009786 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 911045009787 Catalytic site [active] 911045009788 active site 911045009789 UTP binding site [chemical binding]; other site 911045009790 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 911045009791 active site 911045009792 putative oxyanion hole; other site 911045009793 catalytic triad [active] 911045009794 Preprotein translocase SecG subunit; Region: SecG; pfam03840 911045009795 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 911045009796 triosephosphate isomerase; Provisional; Region: PRK14565 911045009797 substrate binding site [chemical binding]; other site 911045009798 dimer interface [polypeptide binding]; other site 911045009799 catalytic triad [active] 911045009800 periplasmic folding chaperone; Provisional; Region: PRK10788 911045009801 SurA N-terminal domain; Region: SurA_N_3; cl07813 911045009802 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 911045009803 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 911045009804 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 911045009805 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 911045009806 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 911045009807 active site 911045009808 ribulose/triose binding site [chemical binding]; other site 911045009809 phosphate binding site [ion binding]; other site 911045009810 substrate (anthranilate) binding pocket [chemical binding]; other site 911045009811 product (indole) binding pocket [chemical binding]; other site 911045009812 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 911045009813 trimer interface [polypeptide binding]; other site 911045009814 dimer interface [polypeptide binding]; other site 911045009815 putative active site [active] 911045009816 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 911045009817 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 911045009818 dimer interface [polypeptide binding]; other site 911045009819 putative functional site; other site 911045009820 putative MPT binding site; other site 911045009821 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 911045009822 Competence protein; Region: Competence; pfam03772 911045009823 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 911045009824 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 911045009825 active site 911045009826 HIGH motif; other site 911045009827 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 911045009828 active site 911045009829 KMSKS motif; other site 911045009830 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 911045009831 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 911045009832 dimer interface [polypeptide binding]; other site 911045009833 active site 911045009834 citrylCoA binding site [chemical binding]; other site 911045009835 NADH binding [chemical binding]; other site 911045009836 cationic pore residues; other site 911045009837 oxalacetate/citrate binding site [chemical binding]; other site 911045009838 coenzyme A binding site [chemical binding]; other site 911045009839 catalytic triad [active] 911045009840 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045009841 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 911045009842 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 911045009843 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 911045009844 acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Region: lipid_A_lpxA; TIGR01852 911045009845 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 911045009846 active site 911045009847 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 911045009848 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 911045009849 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 911045009850 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 911045009851 trimer interface [polypeptide binding]; other site 911045009852 active site 911045009853 UDP-GlcNAc binding site [chemical binding]; other site 911045009854 lipid binding site [chemical binding]; lipid-binding site 911045009855 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 911045009856 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 911045009857 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 911045009858 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 911045009859 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 911045009860 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 911045009861 Surface antigen; Region: Bac_surface_Ag; pfam01103 911045009862 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 911045009863 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 911045009864 active site 911045009865 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 911045009866 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 911045009867 putative substrate binding region [chemical binding]; other site 911045009868 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 911045009869 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 911045009870 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 911045009871 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 911045009872 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 911045009873 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 911045009874 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 911045009875 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 911045009876 catalytic residue [active] 911045009877 putative FPP diphosphate binding site; other site 911045009878 putative FPP binding hydrophobic cleft; other site 911045009879 dimer interface [polypeptide binding]; other site 911045009880 putative IPP diphosphate binding site; other site 911045009881 ribosome recycling factor; Reviewed; Region: frr; PRK00083 911045009882 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 911045009883 hinge region; other site 911045009884 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 911045009885 putative nucleotide binding site [chemical binding]; other site 911045009886 uridine monophosphate binding site [chemical binding]; other site 911045009887 homohexameric interface [polypeptide binding]; other site 911045009888 elongation factor Ts; Provisional; Region: tsf; PRK09377 911045009889 UBA/TS-N domain; Region: UBA; pfam00627 911045009890 Elongation factor TS; Region: EF_TS; pfam00889 911045009891 Elongation factor TS; Region: EF_TS; pfam00889 911045009892 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 911045009893 rRNA interaction site [nucleotide binding]; other site 911045009894 S8 interaction site; other site 911045009895 putative laminin-1 binding site; other site 911045009896 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 911045009897 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 911045009898 putative active site [active] 911045009899 putative PHP Thumb interface [polypeptide binding]; other site 911045009900 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 911045009901 generic binding surface II; other site 911045009902 generic binding surface I; other site 911045009903 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 911045009904 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 911045009905 Walker A/P-loop; other site 911045009906 ATP binding site [chemical binding]; other site 911045009907 Q-loop/lid; other site 911045009908 ABC transporter signature motif; other site 911045009909 Walker B; other site 911045009910 D-loop; other site 911045009911 H-loop/switch region; other site 911045009912 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 911045009913 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 911045009914 FtsX-like permease family; Region: FtsX; pfam02687 911045009915 prolyl-tRNA synthetase; Provisional; Region: PRK12325 911045009916 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 911045009917 dimer interface [polypeptide binding]; other site 911045009918 motif 1; other site 911045009919 active site 911045009920 motif 2; other site 911045009921 motif 3; other site 911045009922 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 911045009923 anticodon binding site; other site 911045009924 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 911045009925 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045009926 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 911045009927 dimer interface [polypeptide binding]; other site 911045009928 substrate binding site [chemical binding]; other site 911045009929 metal binding site [ion binding]; metal-binding site 911045009930 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 911045009931 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045009932 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 911045009933 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 911045009934 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 911045009935 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 911045009936 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 911045009937 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 911045009938 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 911045009939 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 911045009940 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 911045009941 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 911045009942 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 911045009943 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 911045009944 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 911045009945 NADH dehydrogenase subunit 6; Validated; Region: ND6; MTH00021 911045009946 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 911045009947 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 911045009948 4Fe-4S binding domain; Region: Fer4; pfam00037 911045009949 4Fe-4S binding domain; Region: Fer4; pfam00037 911045009950 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 911045009951 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 911045009952 NADH dehydrogenase subunit G; Validated; Region: PRK09130 911045009953 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045009954 catalytic loop [active] 911045009955 iron binding site [ion binding]; other site 911045009956 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 911045009957 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 911045009958 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 911045009959 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 911045009960 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 911045009961 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 911045009962 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 911045009963 SLBB domain; Region: SLBB; pfam10531 911045009964 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 911045009965 NADH dehydrogenase subunit E; Validated; Region: PRK07539 911045009966 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 911045009967 putative dimer interface [polypeptide binding]; other site 911045009968 [2Fe-2S] cluster binding site [ion binding]; other site 911045009969 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 911045009970 NADH dehydrogenase subunit D; Validated; Region: PRK06075 911045009971 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 911045009972 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 911045009973 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 911045009974 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 911045009975 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 911045009976 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 911045009977 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 911045009978 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 911045009979 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 911045009980 IHF dimer interface [polypeptide binding]; other site 911045009981 IHF - DNA interface [nucleotide binding]; other site 911045009982 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 911045009983 Found in ATP-dependent protease La (LON); Region: LON; smart00464 911045009984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045009985 Walker A motif; other site 911045009986 ATP binding site [chemical binding]; other site 911045009987 Walker B motif; other site 911045009988 arginine finger; other site 911045009989 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 911045009990 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 911045009991 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 911045009992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045009993 Walker A motif; other site 911045009994 ATP binding site [chemical binding]; other site 911045009995 Walker B motif; other site 911045009996 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 911045009997 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 911045009998 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 911045009999 oligomer interface [polypeptide binding]; other site 911045010000 active site residues [active] 911045010001 trigger factor; Provisional; Region: tig; PRK01490 911045010002 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 911045010003 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 911045010004 Transcriptional regulators [Transcription]; Region: MarR; COG1846 911045010005 Uncharacterized conserved protein [Function unknown]; Region: COG0062 911045010006 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 911045010007 putative substrate binding site [chemical binding]; other site 911045010008 putative ATP binding site [chemical binding]; other site 911045010009 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045010010 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045010011 active site 911045010012 ATP binding site [chemical binding]; other site 911045010013 substrate binding site [chemical binding]; other site 911045010014 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045010015 substrate binding site [chemical binding]; other site 911045010016 activation loop (A-loop); other site 911045010017 activation loop (A-loop); other site 911045010018 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045010019 active site 911045010020 ATP binding site [chemical binding]; other site 911045010021 substrate binding site [chemical binding]; other site 911045010022 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 911045010023 substrate binding site [chemical binding]; other site 911045010024 activation loop (A-loop); other site 911045010025 activation loop (A-loop); other site 911045010026 Catalytic domain of Protein Kinases; Region: PKc; cd00180 911045010027 active site 911045010028 ATP binding site [chemical binding]; other site 911045010029 substrate binding site [chemical binding]; other site 911045010030 activation loop (A-loop); other site 911045010031 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045010032 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 911045010033 dimer interface [polypeptide binding]; other site 911045010034 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 911045010035 Nitrogen regulatory protein P-II; Region: P-II; smart00938 911045010036 glutamine synthetase; Provisional; Region: glnA; PRK09469 911045010037 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 911045010038 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 911045010039 YceI-like domain; Region: YceI; smart00867 911045010040 MarR family; Region: MarR_2; pfam12802 911045010041 Transcriptional regulators [Transcription]; Region: MarR; COG1846 911045010042 MarR family; Region: MarR_2; cl17246 911045010043 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 911045010044 dimer interface [polypeptide binding]; other site 911045010045 ligand binding site [chemical binding]; other site 911045010046 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 911045010047 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 911045010048 active site 911045010049 HIGH motif; other site 911045010050 dimer interface [polypeptide binding]; other site 911045010051 KMSKS motif; other site 911045010052 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045010053 RNA binding surface [nucleotide binding]; other site 911045010054 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 911045010055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045010056 S-adenosylmethionine binding site [chemical binding]; other site 911045010057 Protein of unknown function; Region: DUF3971; pfam13116 911045010058 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 911045010059 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 911045010060 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 911045010061 catalytic triad [active] 911045010062 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 911045010063 dinuclear metal binding motif [ion binding]; other site 911045010064 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 911045010065 Peptidase family M23; Region: Peptidase_M23; pfam01551 911045010066 peptide chain release factor 2; Provisional; Region: PRK07342 911045010067 This domain is found in peptide chain release factors; Region: PCRF; smart00937 911045010068 RF-1 domain; Region: RF-1; pfam00472 911045010069 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 911045010070 Transglycosylase; Region: Transgly; pfam00912 911045010071 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 911045010072 AMIN domain; Region: AMIN; pfam11741 911045010073 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 911045010074 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 911045010075 active site 911045010076 metal binding site [ion binding]; metal-binding site 911045010077 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 911045010078 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 911045010079 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 911045010080 aspartate aminotransferase; Provisional; Region: PRK05764 911045010081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045010082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045010083 homodimer interface [polypeptide binding]; other site 911045010084 catalytic residue [active] 911045010085 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 911045010086 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 911045010087 catalytic residues [active] 911045010088 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 911045010089 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 911045010090 carboxyltransferase (CT) interaction site; other site 911045010091 biotinylation site [posttranslational modification]; other site 911045010092 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 911045010093 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045010094 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 911045010095 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 911045010096 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 911045010097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 911045010098 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 911045010099 Mechanosensitive ion channel; Region: MS_channel; pfam00924 911045010100 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 911045010101 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 911045010102 HIGH motif; other site 911045010103 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 911045010104 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 911045010105 active site 911045010106 KMSKS motif; other site 911045010107 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 911045010108 tRNA binding surface [nucleotide binding]; other site 911045010109 anticodon binding site; other site 911045010110 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 911045010111 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 911045010112 Outer membrane efflux protein; Region: OEP; pfam02321 911045010113 Outer membrane efflux protein; Region: OEP; pfam02321 911045010114 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 911045010115 Methyltransferase domain; Region: Methyltransf_18; pfam12847 911045010116 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 911045010117 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 911045010118 Fatty acid desaturase; Region: FA_desaturase; pfam00487 911045010119 Di-iron ligands [ion binding]; other site 911045010120 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045010121 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 911045010122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045010123 catalytic residue [active] 911045010124 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 911045010125 cobyric acid synthase; Provisional; Region: PRK00784 911045010126 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 911045010127 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 911045010128 catalytic triad [active] 911045010129 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 911045010130 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 911045010131 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 911045010132 homodimer interface [polypeptide binding]; other site 911045010133 Walker A motif; other site 911045010134 ATP binding site [chemical binding]; other site 911045010135 hydroxycobalamin binding site [chemical binding]; other site 911045010136 Walker B motif; other site 911045010137 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 911045010138 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 911045010139 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 911045010140 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 911045010141 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 911045010142 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 911045010143 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 911045010144 Walker B motif; other site 911045010145 homotrimer interface [polypeptide binding]; other site 911045010146 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 911045010147 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 911045010148 dimer interface [polypeptide binding]; other site 911045010149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045010150 catalytic residue [active] 911045010151 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 911045010152 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 911045010153 putative active site [active] 911045010154 catalytic site [active] 911045010155 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 911045010156 putative active site [active] 911045010157 catalytic site [active] 911045010158 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045010159 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 911045010160 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 911045010161 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 911045010162 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 911045010163 active site residue [active] 911045010164 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 911045010165 active site residue [active] 911045010166 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 911045010167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045010168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045010169 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 911045010170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045010171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045010172 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 911045010173 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 911045010174 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 911045010175 Walker A/P-loop; other site 911045010176 ATP binding site [chemical binding]; other site 911045010177 Q-loop/lid; other site 911045010178 ABC transporter signature motif; other site 911045010179 Walker B; other site 911045010180 D-loop; other site 911045010181 H-loop/switch region; other site 911045010182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010183 dimer interface [polypeptide binding]; other site 911045010184 conserved gate region; other site 911045010185 putative PBP binding loops; other site 911045010186 ABC-ATPase subunit interface; other site 911045010187 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 911045010188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010189 conserved gate region; other site 911045010190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010191 dimer interface [polypeptide binding]; other site 911045010192 conserved gate region; other site 911045010193 putative PBP binding loops; other site 911045010194 ABC-ATPase subunit interface; other site 911045010195 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 911045010196 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045010197 substrate binding pocket [chemical binding]; other site 911045010198 membrane-bound complex binding site; other site 911045010199 hinge residues; other site 911045010200 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 911045010201 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 911045010202 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 911045010203 Ligand binding site; other site 911045010204 Putative Catalytic site; other site 911045010205 DXD motif; other site 911045010206 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 911045010207 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 911045010208 active site 911045010209 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 911045010210 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 911045010211 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 911045010212 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 911045010213 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 911045010214 active site 911045010215 Zn binding site [ion binding]; other site 911045010216 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 911045010217 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 911045010218 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 911045010219 active site 911045010220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045010221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045010222 Coenzyme A binding pocket [chemical binding]; other site 911045010223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045010224 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 911045010225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045010226 Coenzyme A binding pocket [chemical binding]; other site 911045010227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045010228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045010229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045010230 Coenzyme A binding pocket [chemical binding]; other site 911045010231 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 911045010232 DHH family; Region: DHH; pfam01368 911045010233 DHHA1 domain; Region: DHHA1; pfam02272 911045010234 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 911045010235 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 911045010236 putative active site [active] 911045010237 homoserine dehydrogenase; Provisional; Region: PRK06349 911045010238 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 911045010239 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 911045010240 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 911045010241 aminotransferase; Validated; Region: PRK09148 911045010242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045010243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045010244 homodimer interface [polypeptide binding]; other site 911045010245 catalytic residue [active] 911045010246 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 911045010247 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 911045010248 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 911045010249 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 911045010250 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 911045010251 23S rRNA interface [nucleotide binding]; other site 911045010252 L3 interface [polypeptide binding]; other site 911045010253 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 911045010254 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 911045010255 Leucine-rich repeats; other site 911045010256 Leucine rich repeat; Region: LRR_8; pfam13855 911045010257 Substrate binding site [chemical binding]; other site 911045010258 Leucine rich repeat; Region: LRR_8; pfam13855 911045010259 Leucine rich repeat; Region: LRR_8; pfam13855 911045010260 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045010261 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 911045010262 conserved cys residue [active] 911045010263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045010264 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 911045010265 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 911045010266 conserved cys residue [active] 911045010267 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 911045010268 CoenzymeA binding site [chemical binding]; other site 911045010269 subunit interaction site [polypeptide binding]; other site 911045010270 PHB binding site; other site 911045010271 enoyl-CoA hydratase; Validated; Region: PRK08139 911045010272 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045010273 substrate binding site [chemical binding]; other site 911045010274 oxyanion hole (OAH) forming residues; other site 911045010275 trimer interface [polypeptide binding]; other site 911045010276 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 911045010277 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 911045010278 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 911045010279 homodimer interface [polypeptide binding]; other site 911045010280 substrate-cofactor binding pocket; other site 911045010281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045010282 catalytic residue [active] 911045010283 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 911045010284 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 911045010285 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 911045010286 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 911045010287 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 911045010288 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 911045010289 putative active site [active] 911045010290 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 911045010291 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 911045010292 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 911045010293 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 911045010294 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 911045010295 SLBB domain; Region: SLBB; pfam10531 911045010296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045010297 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 911045010298 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 911045010299 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 911045010300 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 911045010301 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 911045010302 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 911045010303 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 911045010304 hypothetical protein; Provisional; Region: PRK06148 911045010305 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 911045010306 active site 911045010307 ATP binding site [chemical binding]; other site 911045010308 Peptidase family M23; Region: Peptidase_M23; pfam01551 911045010309 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045010310 inhibitor-cofactor binding pocket; inhibition site 911045010311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045010312 catalytic residue [active] 911045010313 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045010314 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 911045010315 putative DNA binding site [nucleotide binding]; other site 911045010316 putative Zn2+ binding site [ion binding]; other site 911045010317 AsnC family; Region: AsnC_trans_reg; pfam01037 911045010318 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 911045010319 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 911045010320 DNA binding residues [nucleotide binding] 911045010321 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 911045010322 IHF dimer interface [polypeptide binding]; other site 911045010323 IHF - DNA interface [nucleotide binding]; other site 911045010324 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 911045010325 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 911045010326 dimer interface [polypeptide binding]; other site 911045010327 active site 911045010328 CoA binding pocket [chemical binding]; other site 911045010329 putative phosphate acyltransferase; Provisional; Region: PRK05331 911045010330 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 911045010331 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981 911045010332 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 911045010333 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 911045010334 Protein of unknown function, DUF417; Region: DUF417; cl01162 911045010335 Protein of unknown function, DUF417; Region: DUF417; cl01162 911045010336 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045010337 active site 911045010338 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 911045010339 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 911045010340 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 911045010341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045010342 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045010343 putative substrate translocation pore; other site 911045010344 thiamine monophosphate kinase; Provisional; Region: PRK05731 911045010345 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 911045010346 ATP binding site [chemical binding]; other site 911045010347 dimerization interface [polypeptide binding]; other site 911045010348 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 911045010349 putative RNA binding site [nucleotide binding]; other site 911045010350 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 911045010351 homopentamer interface [polypeptide binding]; other site 911045010352 active site 911045010353 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 911045010354 Lumazine binding domain; Region: Lum_binding; pfam00677 911045010355 Lumazine binding domain; Region: Lum_binding; pfam00677 911045010356 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 911045010357 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 911045010358 catalytic motif [active] 911045010359 Zn binding site [ion binding]; other site 911045010360 RibD C-terminal domain; Region: RibD_C; cl17279 911045010361 ATP cone domain; Region: ATP-cone; pfam03477 911045010362 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 911045010363 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 911045010364 dimer interface [polypeptide binding]; other site 911045010365 active site 911045010366 glycine-pyridoxal phosphate binding site [chemical binding]; other site 911045010367 folate binding site [chemical binding]; other site 911045010368 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 911045010369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 911045010370 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 911045010371 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 911045010372 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 911045010373 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 911045010374 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 911045010375 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 911045010376 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 911045010377 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045010378 substrate binding site [chemical binding]; other site 911045010379 oxyanion hole (OAH) forming residues; other site 911045010380 trimer interface [polypeptide binding]; other site 911045010381 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 911045010382 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045010383 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 911045010384 substrate binding pocket [chemical binding]; other site 911045010385 FAD binding site [chemical binding]; other site 911045010386 catalytic base [active] 911045010387 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 911045010388 dimer interface [polypeptide binding]; other site 911045010389 allosteric magnesium binding site [ion binding]; other site 911045010390 active site 911045010391 aspartate-rich active site metal binding site; other site 911045010392 Schiff base residues; other site 911045010393 threonine dehydratase; Provisional; Region: PRK07334 911045010394 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045010395 tetramer interface [polypeptide binding]; other site 911045010396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045010397 catalytic residue [active] 911045010398 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 911045010399 RDD family; Region: RDD; pfam06271 911045010400 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 911045010401 transmembrane helices; other site 911045010402 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 911045010403 TrkA-C domain; Region: TrkA_C; pfam02080 911045010404 TrkA-C domain; Region: TrkA_C; pfam02080 911045010405 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 911045010406 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 911045010407 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 911045010408 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 911045010409 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 911045010410 ligand binding site [chemical binding]; other site 911045010411 active site 911045010412 Uncharacterized conserved protein [Function unknown]; Region: COG1432 911045010413 LabA_like proteins; Region: LabA; cd10911 911045010414 putative metal binding site [ion binding]; other site 911045010415 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 911045010416 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 911045010417 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 911045010418 Zn2+ binding site [ion binding]; other site 911045010419 Mg2+ binding site [ion binding]; other site 911045010420 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 911045010421 synthetase active site [active] 911045010422 NTP binding site [chemical binding]; other site 911045010423 metal binding site [ion binding]; metal-binding site 911045010424 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 911045010425 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 911045010426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045010427 active site 911045010428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 911045010429 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 911045010430 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 911045010431 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 911045010432 Catalytic site [active] 911045010433 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 911045010434 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 911045010435 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 911045010436 dimerization interface [polypeptide binding]; other site 911045010437 active site 911045010438 metal binding site [ion binding]; metal-binding site 911045010439 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 911045010440 dsRNA binding site [nucleotide binding]; other site 911045010441 GTPase Era; Reviewed; Region: era; PRK00089 911045010442 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 911045010443 G1 box; other site 911045010444 GTP/Mg2+ binding site [chemical binding]; other site 911045010445 Switch I region; other site 911045010446 G2 box; other site 911045010447 Switch II region; other site 911045010448 G3 box; other site 911045010449 G4 box; other site 911045010450 G5 box; other site 911045010451 KH domain; Region: KH_2; pfam07650 911045010452 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 911045010453 Recombination protein O N terminal; Region: RecO_N; pfam11967 911045010454 Recombination protein O C terminal; Region: RecO_C; pfam02565 911045010455 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 911045010456 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 911045010457 CAP-like domain; other site 911045010458 active site 911045010459 primary dimer interface [polypeptide binding]; other site 911045010460 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 911045010461 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045010462 active site 911045010463 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 911045010464 SmpB-tmRNA interface; other site 911045010465 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 911045010466 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 911045010467 dimer interface [polypeptide binding]; other site 911045010468 active site 911045010469 catalytic residue [active] 911045010470 Tetratricopeptide repeat; Region: TPR_12; pfam13424 911045010471 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 911045010472 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 911045010473 N-acetyl-D-glucosamine binding site [chemical binding]; other site 911045010474 catalytic residue [active] 911045010475 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 911045010476 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 911045010477 Porin subfamily; Region: Porin_2; pfam02530 911045010478 Porin subfamily; Region: Porin_2; pfam02530 911045010479 Porin subfamily; Region: Porin_2; pfam02530 911045010480 Porin subfamily; Region: Porin_2; pfam02530 911045010481 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 911045010482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010483 dimer interface [polypeptide binding]; other site 911045010484 conserved gate region; other site 911045010485 ABC-ATPase subunit interface; other site 911045010486 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 911045010487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010488 dimer interface [polypeptide binding]; other site 911045010489 conserved gate region; other site 911045010490 putative PBP binding loops; other site 911045010491 ABC-ATPase subunit interface; other site 911045010492 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 911045010493 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 911045010494 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 911045010495 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 911045010496 Walker A/P-loop; other site 911045010497 ATP binding site [chemical binding]; other site 911045010498 Q-loop/lid; other site 911045010499 ABC transporter signature motif; other site 911045010500 Walker B; other site 911045010501 D-loop; other site 911045010502 H-loop/switch region; other site 911045010503 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045010504 Coenzyme A binding pocket [chemical binding]; other site 911045010505 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 911045010506 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 911045010507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045010508 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 911045010509 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045010510 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045010511 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 911045010512 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 911045010513 Walker A/P-loop; other site 911045010514 ATP binding site [chemical binding]; other site 911045010515 Q-loop/lid; other site 911045010516 ABC transporter signature motif; other site 911045010517 Walker B; other site 911045010518 D-loop; other site 911045010519 H-loop/switch region; other site 911045010520 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 911045010521 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 911045010522 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 911045010523 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 911045010524 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 911045010525 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 911045010526 nucleotide binding site [chemical binding]; other site 911045010527 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 911045010528 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045010529 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045010530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010531 dimer interface [polypeptide binding]; other site 911045010532 conserved gate region; other site 911045010533 putative PBP binding loops; other site 911045010534 ABC-ATPase subunit interface; other site 911045010535 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045010536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010537 dimer interface [polypeptide binding]; other site 911045010538 conserved gate region; other site 911045010539 putative PBP binding loops; other site 911045010540 ABC-ATPase subunit interface; other site 911045010541 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 911045010542 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 911045010543 active sites [active] 911045010544 tetramer interface [polypeptide binding]; other site 911045010545 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045010546 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045010547 Walker A/P-loop; other site 911045010548 ATP binding site [chemical binding]; other site 911045010549 Q-loop/lid; other site 911045010550 ABC transporter signature motif; other site 911045010551 Walker B; other site 911045010552 D-loop; other site 911045010553 H-loop/switch region; other site 911045010554 TOBE domain; Region: TOBE_2; pfam08402 911045010555 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045010556 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045010557 substrate binding site [chemical binding]; other site 911045010558 ATP binding site [chemical binding]; other site 911045010559 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045010560 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045010561 DNA binding site [nucleotide binding] 911045010562 domain linker motif; other site 911045010563 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045010564 ligand binding site [chemical binding]; other site 911045010565 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045010566 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045010567 substrate binding pocket [chemical binding]; other site 911045010568 membrane-bound complex binding site; other site 911045010569 hinge residues; other site 911045010570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010571 dimer interface [polypeptide binding]; other site 911045010572 conserved gate region; other site 911045010573 putative PBP binding loops; other site 911045010574 ABC-ATPase subunit interface; other site 911045010575 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 911045010576 beta-galactosidase; Region: BGL; TIGR03356 911045010577 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 911045010578 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045010579 putative aminotransferase; Validated; Region: PRK07480 911045010580 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 911045010581 inhibitor-cofactor binding pocket; inhibition site 911045010582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045010583 catalytic residue [active] 911045010584 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045010585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045010586 DNA-binding site [nucleotide binding]; DNA binding site 911045010587 FCD domain; Region: FCD; pfam07729 911045010588 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 911045010589 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 911045010590 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045010591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045010592 Walker A/P-loop; other site 911045010593 ATP binding site [chemical binding]; other site 911045010594 Q-loop/lid; other site 911045010595 ABC transporter signature motif; other site 911045010596 Walker B; other site 911045010597 D-loop; other site 911045010598 H-loop/switch region; other site 911045010599 TOBE domain; Region: TOBE_2; pfam08402 911045010600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010601 dimer interface [polypeptide binding]; other site 911045010602 conserved gate region; other site 911045010603 putative PBP binding loops; other site 911045010604 ABC-ATPase subunit interface; other site 911045010605 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045010606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045010607 dimer interface [polypeptide binding]; other site 911045010608 conserved gate region; other site 911045010609 putative PBP binding loops; other site 911045010610 ABC-ATPase subunit interface; other site 911045010611 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 911045010612 oligomer interface [polypeptide binding]; other site 911045010613 putative active site [active] 911045010614 Mn binding site [ion binding]; other site 911045010615 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 911045010616 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 911045010617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045010618 NAD(P) binding site [chemical binding]; other site 911045010619 active site 911045010620 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045010621 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 911045010622 putative NAD(P) binding site [chemical binding]; other site 911045010623 active site 911045010624 putative substrate binding site [chemical binding]; other site 911045010625 bile acid transporter; Region: bass; TIGR00841 911045010626 Sodium Bile acid symporter family; Region: SBF; cl17470 911045010627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 911045010628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045010629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045010630 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045010631 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045010632 DctM-like transporters; Region: DctM; pfam06808 911045010633 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045010634 enoyl-CoA hydratase; Provisional; Region: PRK07511 911045010635 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045010636 substrate binding site [chemical binding]; other site 911045010637 oxyanion hole (OAH) forming residues; other site 911045010638 trimer interface [polypeptide binding]; other site 911045010639 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 911045010640 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 911045010641 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 911045010642 active site 911045010643 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 911045010644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045010645 active site 911045010646 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045010647 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 911045010648 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045010649 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 911045010650 Walker A/P-loop; other site 911045010651 ATP binding site [chemical binding]; other site 911045010652 Q-loop/lid; other site 911045010653 ABC transporter signature motif; other site 911045010654 Walker B; other site 911045010655 D-loop; other site 911045010656 H-loop/switch region; other site 911045010657 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045010658 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 911045010659 Walker A/P-loop; other site 911045010660 ATP binding site [chemical binding]; other site 911045010661 Q-loop/lid; other site 911045010662 ABC transporter signature motif; other site 911045010663 Walker B; other site 911045010664 D-loop; other site 911045010665 H-loop/switch region; other site 911045010666 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045010667 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045010668 TM-ABC transporter signature motif; other site 911045010669 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045010670 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045010671 TM-ABC transporter signature motif; other site 911045010672 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045010673 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 911045010674 putative ligand binding site [chemical binding]; other site 911045010675 Tir chaperone protein (CesT) family; Region: CesT; cl08444 911045010676 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 911045010677 FHIPEP family; Region: FHIPEP; pfam00771 911045010678 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045010679 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 911045010680 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 911045010681 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 911045010682 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 911045010683 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 911045010684 type III secretion system protein YscR; Provisional; Region: PRK12797 911045010685 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 911045010686 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 911045010687 type III secretion system ATPase; Provisional; Region: PRK06936 911045010688 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 911045010689 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 911045010690 Walker A motif/ATP binding site; other site 911045010691 Walker B motif; other site 911045010692 type III secretion system protein; Reviewed; Region: PRK06937 911045010693 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 911045010694 Type III secretion needle MxiH like; Region: MxiH; cl09641 911045010695 type II secretion system protein D; Region: type_II_gspD; TIGR02517 911045010696 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 911045010697 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 911045010698 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 911045010699 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 911045010700 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 911045010701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045010702 TPR motif; other site 911045010703 binding surface 911045010704 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 911045010705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045010706 TPR motif; other site 911045010707 binding surface 911045010708 HrpJ-like domain; Region: HrpJ; cl15454 911045010709 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 911045010710 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045010711 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045010712 ligand binding site [chemical binding]; other site 911045010713 flexible hinge region; other site 911045010714 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 911045010715 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 911045010716 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010717 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010718 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010719 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010720 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 911045010721 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010722 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010723 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010724 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 911045010725 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045010726 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 911045010727 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045010728 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045010729 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045010730 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 911045010731 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 911045010732 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045010733 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 911045010734 Walker A/P-loop; other site 911045010735 ATP binding site [chemical binding]; other site 911045010736 Q-loop/lid; other site 911045010737 ABC transporter signature motif; other site 911045010738 Walker B; other site 911045010739 D-loop; other site 911045010740 H-loop/switch region; other site 911045010741 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 911045010742 DctM-like transporters; Region: DctM; pfam06808 911045010743 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045010744 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045010745 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045010746 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045010747 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 911045010748 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 911045010749 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 911045010750 putative active site [active] 911045010751 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 911045010752 Predicted amidohydrolase [General function prediction only]; Region: COG0388 911045010753 active site 911045010754 catalytic triad [active] 911045010755 dimer interface [polypeptide binding]; other site 911045010756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045010757 enoyl-CoA hydratase; Provisional; Region: PRK09245 911045010758 substrate binding site [chemical binding]; other site 911045010759 oxyanion hole (OAH) forming residues; other site 911045010760 trimer interface [polypeptide binding]; other site 911045010761 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 911045010762 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 911045010763 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045010764 catalytic loop [active] 911045010765 iron binding site [ion binding]; other site 911045010766 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 911045010767 4Fe-4S binding domain; Region: Fer4; pfam00037 911045010768 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 911045010769 [4Fe-4S] binding site [ion binding]; other site 911045010770 molybdopterin cofactor binding site; other site 911045010771 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 911045010772 molybdopterin cofactor binding site; other site 911045010773 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045010774 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 911045010775 SLBB domain; Region: SLBB; pfam10531 911045010776 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 911045010777 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 911045010778 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 911045010779 putative dimer interface [polypeptide binding]; other site 911045010780 [2Fe-2S] cluster binding site [ion binding]; other site 911045010781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045010782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045010783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 911045010784 dimerization interface [polypeptide binding]; other site 911045010785 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 911045010786 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 911045010787 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 911045010788 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 911045010789 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 911045010790 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 911045010791 Sulfatase; Region: Sulfatase; pfam00884 911045010792 beta-lactamase TEM; Provisional; Region: PRK15442 911045010793 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 911045010794 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045010795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045010796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045010797 dimerization interface [polypeptide binding]; other site 911045010798 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 911045010799 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 911045010800 multidrug resistance protein MdtN; Provisional; Region: PRK10476 911045010801 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045010802 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045010803 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 911045010804 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 911045010805 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 911045010806 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 911045010807 catalytic residues [active] 911045010808 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 911045010809 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 911045010810 C-terminal domain interface [polypeptide binding]; other site 911045010811 GSH binding site (G-site) [chemical binding]; other site 911045010812 dimer interface [polypeptide binding]; other site 911045010813 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 911045010814 N-terminal domain interface [polypeptide binding]; other site 911045010815 putative dimer interface [polypeptide binding]; other site 911045010816 active site 911045010817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045010818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045010819 Coenzyme A binding pocket [chemical binding]; other site 911045010820 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 911045010821 glucosyltransferase MdoH; Provisional; Region: PRK05454 911045010822 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045010823 active site 911045010824 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 911045010825 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 911045010826 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045010827 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045010828 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 911045010829 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 911045010830 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 911045010831 GatB domain; Region: GatB_Yqey; smart00845 911045010832 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; pfam09857 911045010833 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045010834 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045010835 dimerization interface [polypeptide binding]; other site 911045010836 putative DNA binding site [nucleotide binding]; other site 911045010837 putative Zn2+ binding site [ion binding]; other site 911045010838 laccase, plant; Region: laccase; TIGR03389 911045010839 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 911045010840 Multicopper oxidase; Region: Cu-oxidase; pfam00394 911045010841 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 911045010842 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045010843 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045010844 Isochorismatase family; Region: Isochorismatase; pfam00857 911045010845 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 911045010846 catalytic triad [active] 911045010847 conserved cis-peptide bond; other site 911045010848 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 911045010849 NADH(P)-binding; Region: NAD_binding_10; pfam13460 911045010850 putative NAD(P) binding site [chemical binding]; other site 911045010851 active site 911045010852 DoxX-like family; Region: DoxX_3; pfam13781 911045010853 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 911045010854 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 911045010855 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 911045010856 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 911045010857 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045010858 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 911045010859 conserved cys residue [active] 911045010860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045010861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045010862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045010863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045010864 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 911045010865 YHS domain; Region: YHS; pfam04945 911045010866 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 911045010867 metal-dependent hydrolase; Provisional; Region: PRK00685 911045010868 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 911045010869 ligand binding site [chemical binding]; other site 911045010870 active site 911045010871 UGI interface [polypeptide binding]; other site 911045010872 catalytic site [active] 911045010873 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 911045010874 Predicted permeases [General function prediction only]; Region: COG0679 911045010875 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045010876 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045010877 active site 911045010878 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 911045010879 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 911045010880 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 911045010881 dihydroorotase; Validated; Region: PRK09059 911045010882 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045010883 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 911045010884 active site 911045010885 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 911045010886 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 911045010887 DNA protecting protein DprA; Region: dprA; TIGR00732 911045010888 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 911045010889 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 911045010890 active site 911045010891 interdomain interaction site; other site 911045010892 putative metal-binding site [ion binding]; other site 911045010893 nucleotide binding site [chemical binding]; other site 911045010894 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 911045010895 domain I; other site 911045010896 DNA binding groove [nucleotide binding] 911045010897 phosphate binding site [ion binding]; other site 911045010898 domain II; other site 911045010899 domain III; other site 911045010900 nucleotide binding site [chemical binding]; other site 911045010901 catalytic site [active] 911045010902 domain IV; other site 911045010903 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 911045010904 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 911045010905 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 911045010906 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 911045010907 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 911045010908 ribonuclease R; Region: RNase_R; TIGR02063 911045010909 RNB domain; Region: RNB; pfam00773 911045010910 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 911045010911 RNA binding site [nucleotide binding]; other site 911045010912 Protein of unknown function (DUF983); Region: DUF983; cl02211 911045010913 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045010914 NUDIX domain; Region: NUDIX; pfam00293 911045010915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045010916 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045010917 putative substrate translocation pore; other site 911045010918 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 911045010919 Response regulator receiver domain; Region: Response_reg; pfam00072 911045010920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045010921 active site 911045010922 phosphorylation site [posttranslational modification] 911045010923 intermolecular recognition site; other site 911045010924 dimerization interface [polypeptide binding]; other site 911045010925 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 911045010926 hypothetical protein; Provisional; Region: 30.2; PHA02597 911045010927 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 911045010928 DNA polymerase IV; Provisional; Region: PRK02794 911045010929 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 911045010930 active site 911045010931 DNA binding site [nucleotide binding] 911045010932 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 911045010933 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 911045010934 homotrimer interaction site [polypeptide binding]; other site 911045010935 putative active site [active] 911045010936 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 911045010937 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 911045010938 active site 911045010939 catalytic site [active] 911045010940 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 911045010941 Protein of unknown function, DUF482; Region: DUF482; pfam04339 911045010942 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 911045010943 HIT family signature motif; other site 911045010944 catalytic residue [active] 911045010945 YoaP-like; Region: YoaP; pfam14268 911045010946 AzlC protein; Region: AzlC; cl00570 911045010947 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 911045010948 Clp amino terminal domain; Region: Clp_N; pfam02861 911045010949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045010950 Walker A motif; other site 911045010951 ATP binding site [chemical binding]; other site 911045010952 Walker B motif; other site 911045010953 arginine finger; other site 911045010954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045010955 Walker A motif; other site 911045010956 ATP binding site [chemical binding]; other site 911045010957 Walker B motif; other site 911045010958 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 911045010959 Uncharacterized conserved protein [Function unknown]; Region: COG2127 911045010960 Phasin protein; Region: Phasin_2; pfam09361 911045010961 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 911045010962 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 911045010963 Sporulation related domain; Region: SPOR; pfam05036 911045010964 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 911045010965 HSP70 interaction site [polypeptide binding]; other site 911045010966 von Willebrand factor type A domain; Region: VWA_2; pfam13519 911045010967 pantoate--beta-alanine ligase; Region: panC; TIGR00018 911045010968 Pantoate-beta-alanine ligase; Region: PanC; cd00560 911045010969 active site 911045010970 ATP-binding site [chemical binding]; other site 911045010971 pantoate-binding site; other site 911045010972 HXXH motif; other site 911045010973 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 911045010974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045010975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045010976 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 911045010977 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 911045010978 putative NAD(P) binding site [chemical binding]; other site 911045010979 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 911045010980 cyclase homology domain; Region: CHD; cd07302 911045010981 nucleotidyl binding site; other site 911045010982 metal binding site [ion binding]; metal-binding site 911045010983 dimer interface [polypeptide binding]; other site 911045010984 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 911045010985 thiamine phosphate binding site [chemical binding]; other site 911045010986 active site 911045010987 pyrophosphate binding site [ion binding]; other site 911045010988 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 911045010989 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 911045010990 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 911045010991 oligomer interface [polypeptide binding]; other site 911045010992 active site residues [active] 911045010993 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 911045010994 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045010995 metal binding site [ion binding]; metal-binding site 911045010996 active site 911045010997 I-site; other site 911045010998 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045010999 ACT domain; Region: ACT_3; pfam10000 911045011000 Family description; Region: ACT_7; pfam13840 911045011001 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045011002 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 911045011003 putative metal binding site [ion binding]; other site 911045011004 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 911045011005 MgtE intracellular N domain; Region: MgtE_N; smart00924 911045011006 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 911045011007 Divalent cation transporter; Region: MgtE; cl00786 911045011008 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 911045011009 lipoate-protein ligase B; Provisional; Region: PRK14341 911045011010 Acylphosphatase; Region: Acylphosphatase; pfam00708 911045011011 EamA-like transporter family; Region: EamA; pfam00892 911045011012 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 911045011013 putative active site pocket [active] 911045011014 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 911045011015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045011016 motif II; other site 911045011017 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 911045011018 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045011019 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 911045011020 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 911045011021 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 911045011022 carboxyltransferase (CT) interaction site; other site 911045011023 biotinylation site [posttranslational modification]; other site 911045011024 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 911045011025 homooctamer interface [polypeptide binding]; other site 911045011026 active site 911045011027 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 911045011028 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 911045011029 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 911045011030 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 911045011031 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 911045011032 heme binding site [chemical binding]; other site 911045011033 ferroxidase pore; other site 911045011034 ferroxidase diiron center [ion binding]; other site 911045011035 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 911045011036 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 911045011037 heme binding site [chemical binding]; other site 911045011038 ferroxidase pore; other site 911045011039 ferroxidase diiron center [ion binding]; other site 911045011040 ATP12 chaperone protein; Region: ATP12; cl02228 911045011041 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 911045011042 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 911045011043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045011044 motif II; other site 911045011045 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 911045011046 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 911045011047 active site 911045011048 CrcB-like protein; Region: CRCB; cl09114 911045011049 patatin-related protein; Region: TIGR03607 911045011050 recombination factor protein RarA; Reviewed; Region: PRK13342 911045011051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045011052 Walker A motif; other site 911045011053 ATP binding site [chemical binding]; other site 911045011054 Walker B motif; other site 911045011055 arginine finger; other site 911045011056 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 911045011057 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 911045011058 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 911045011059 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045011060 protein binding site [polypeptide binding]; other site 911045011061 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045011062 protein binding site [polypeptide binding]; other site 911045011063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045011064 dimerization interface [polypeptide binding]; other site 911045011065 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045011066 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045011067 dimer interface [polypeptide binding]; other site 911045011068 putative CheW interface [polypeptide binding]; other site 911045011069 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 911045011070 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 911045011071 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 911045011072 alphaNTD - beta interaction site [polypeptide binding]; other site 911045011073 alphaNTD homodimer interface [polypeptide binding]; other site 911045011074 alphaNTD - beta' interaction site [polypeptide binding]; other site 911045011075 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 911045011076 30S ribosomal protein S11; Validated; Region: PRK05309 911045011077 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 911045011078 30S ribosomal protein S13; Region: bact_S13; TIGR03631 911045011079 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 911045011080 adenylate kinase; Reviewed; Region: adk; PRK00279 911045011081 AMP-binding site [chemical binding]; other site 911045011082 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 911045011083 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 911045011084 SecY translocase; Region: SecY; pfam00344 911045011085 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 911045011086 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 911045011087 23S rRNA binding site [nucleotide binding]; other site 911045011088 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 911045011089 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 911045011090 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 911045011091 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 911045011092 23S rRNA interface [nucleotide binding]; other site 911045011093 L21e interface [polypeptide binding]; other site 911045011094 5S rRNA interface [nucleotide binding]; other site 911045011095 L27 interface [polypeptide binding]; other site 911045011096 L5 interface [polypeptide binding]; other site 911045011097 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 911045011098 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 911045011099 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 911045011100 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 911045011101 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 911045011102 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 911045011103 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 911045011104 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 911045011105 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 911045011106 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 911045011107 RNA binding site [nucleotide binding]; other site 911045011108 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 911045011109 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 911045011110 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 911045011111 23S rRNA interface [nucleotide binding]; other site 911045011112 putative translocon interaction site; other site 911045011113 signal recognition particle (SRP54) interaction site; other site 911045011114 L23 interface [polypeptide binding]; other site 911045011115 trigger factor interaction site; other site 911045011116 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 911045011117 23S rRNA interface [nucleotide binding]; other site 911045011118 5S rRNA interface [nucleotide binding]; other site 911045011119 putative antibiotic binding site [chemical binding]; other site 911045011120 L25 interface [polypeptide binding]; other site 911045011121 L27 interface [polypeptide binding]; other site 911045011122 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 911045011123 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 911045011124 G-X-X-G motif; other site 911045011125 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 911045011126 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 911045011127 putative translocon binding site; other site 911045011128 protein-rRNA interface [nucleotide binding]; other site 911045011129 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 911045011130 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 911045011131 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 911045011132 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 911045011133 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 911045011134 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 911045011135 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 911045011136 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 911045011137 elongation factor Tu; Reviewed; Region: PRK00049 911045011138 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 911045011139 G1 box; other site 911045011140 GEF interaction site [polypeptide binding]; other site 911045011141 GTP/Mg2+ binding site [chemical binding]; other site 911045011142 Switch I region; other site 911045011143 G2 box; other site 911045011144 G3 box; other site 911045011145 Switch II region; other site 911045011146 G4 box; other site 911045011147 G5 box; other site 911045011148 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 911045011149 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 911045011150 Antibiotic Binding Site [chemical binding]; other site 911045011151 elongation factor G; Reviewed; Region: PRK00007 911045011152 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 911045011153 G1 box; other site 911045011154 putative GEF interaction site [polypeptide binding]; other site 911045011155 GTP/Mg2+ binding site [chemical binding]; other site 911045011156 Switch I region; other site 911045011157 G2 box; other site 911045011158 G3 box; other site 911045011159 Switch II region; other site 911045011160 G4 box; other site 911045011161 G5 box; other site 911045011162 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 911045011163 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 911045011164 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 911045011165 30S ribosomal protein S7; Validated; Region: PRK05302 911045011166 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 911045011167 S17 interaction site [polypeptide binding]; other site 911045011168 S8 interaction site; other site 911045011169 16S rRNA interaction site [nucleotide binding]; other site 911045011170 streptomycin interaction site [chemical binding]; other site 911045011171 23S rRNA interaction site [nucleotide binding]; other site 911045011172 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 911045011173 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 911045011174 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 911045011175 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 911045011176 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 911045011177 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 911045011178 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 911045011179 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 911045011180 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 911045011181 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 911045011182 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 911045011183 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 911045011184 DNA binding site [nucleotide binding] 911045011185 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 911045011186 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 911045011187 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 911045011188 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 911045011189 RPB11 interaction site [polypeptide binding]; other site 911045011190 RPB12 interaction site [polypeptide binding]; other site 911045011191 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 911045011192 RPB3 interaction site [polypeptide binding]; other site 911045011193 RPB1 interaction site [polypeptide binding]; other site 911045011194 RPB11 interaction site [polypeptide binding]; other site 911045011195 RPB10 interaction site [polypeptide binding]; other site 911045011196 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 911045011197 core dimer interface [polypeptide binding]; other site 911045011198 peripheral dimer interface [polypeptide binding]; other site 911045011199 L10 interface [polypeptide binding]; other site 911045011200 L11 interface [polypeptide binding]; other site 911045011201 putative EF-Tu interaction site [polypeptide binding]; other site 911045011202 putative EF-G interaction site [polypeptide binding]; other site 911045011203 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 911045011204 23S rRNA interface [nucleotide binding]; other site 911045011205 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 911045011206 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 911045011207 mRNA/rRNA interface [nucleotide binding]; other site 911045011208 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 911045011209 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 911045011210 23S rRNA interface [nucleotide binding]; other site 911045011211 L7/L12 interface [polypeptide binding]; other site 911045011212 putative thiostrepton binding site; other site 911045011213 L25 interface [polypeptide binding]; other site 911045011214 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 911045011215 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 911045011216 putative homodimer interface [polypeptide binding]; other site 911045011217 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 911045011218 heterodimer interface [polypeptide binding]; other site 911045011219 homodimer interface [polypeptide binding]; other site 911045011220 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 911045011221 elongation factor Tu; Reviewed; Region: PRK00049 911045011222 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 911045011223 G1 box; other site 911045011224 GEF interaction site [polypeptide binding]; other site 911045011225 GTP/Mg2+ binding site [chemical binding]; other site 911045011226 Switch I region; other site 911045011227 G2 box; other site 911045011228 G3 box; other site 911045011229 Switch II region; other site 911045011230 G4 box; other site 911045011231 G5 box; other site 911045011232 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 911045011233 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 911045011234 Antibiotic Binding Site [chemical binding]; other site 911045011235 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 911045011236 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 911045011237 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 911045011238 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 911045011239 active site 911045011240 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011241 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045011242 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 911045011243 active site 911045011244 metal binding site [ion binding]; metal-binding site 911045011245 interdomain interaction site; other site 911045011246 hypothetical protein; Validated; Region: PRK07078 911045011247 Helix-turn-helix domain; Region: HTH_17; pfam12728 911045011248 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 911045011249 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 911045011250 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 911045011251 active site 911045011252 intersubunit interface [polypeptide binding]; other site 911045011253 catalytic residue [active] 911045011254 Major royal jelly protein; Region: MRJP; pfam03022 911045011255 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045011256 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045011257 substrate binding site [chemical binding]; other site 911045011258 ATP binding site [chemical binding]; other site 911045011259 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 911045011260 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 911045011261 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 911045011262 ligand binding site [chemical binding]; other site 911045011263 NAD binding site [chemical binding]; other site 911045011264 catalytic site [active] 911045011265 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045011266 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 911045011267 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 911045011268 DctM-like transporters; Region: DctM; pfam06808 911045011269 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045011270 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045011271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045011272 DNA-binding site [nucleotide binding]; DNA binding site 911045011273 FCD domain; Region: FCD; pfam07729 911045011274 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045011275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045011276 LysR substrate binding domain; Region: LysR_substrate; pfam03466 911045011277 dimerization interface [polypeptide binding]; other site 911045011278 Major royal jelly protein; Region: MRJP; pfam03022 911045011279 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 911045011280 putative catalytic residue [active] 911045011281 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045011282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045011283 dimer interface [polypeptide binding]; other site 911045011284 conserved gate region; other site 911045011285 putative PBP binding loops; other site 911045011286 ABC-ATPase subunit interface; other site 911045011287 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 911045011288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045011289 dimer interface [polypeptide binding]; other site 911045011290 conserved gate region; other site 911045011291 putative PBP binding loops; other site 911045011292 ABC-ATPase subunit interface; other site 911045011293 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 911045011294 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045011295 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 911045011296 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 911045011297 active site 911045011298 catalytic site [active] 911045011299 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045011300 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045011301 DNA binding site [nucleotide binding] 911045011302 domain linker motif; other site 911045011303 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045011304 ligand binding site [chemical binding]; other site 911045011305 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045011306 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045011307 Walker A/P-loop; other site 911045011308 ATP binding site [chemical binding]; other site 911045011309 Q-loop/lid; other site 911045011310 ABC transporter signature motif; other site 911045011311 Walker B; other site 911045011312 D-loop; other site 911045011313 H-loop/switch region; other site 911045011314 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 911045011315 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 911045011316 Part of AAA domain; Region: AAA_19; pfam13245 911045011317 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 911045011318 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 911045011319 putative active site [active] 911045011320 putative metal-binding site [ion binding]; other site 911045011321 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045011322 active site 911045011323 DNA binding site [nucleotide binding] 911045011324 Int/Topo IB signature motif; other site 911045011325 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 911045011326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045011327 dimer interface [polypeptide binding]; other site 911045011328 phosphorylation site [posttranslational modification] 911045011329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045011330 ATP binding site [chemical binding]; other site 911045011331 Mg2+ binding site [ion binding]; other site 911045011332 G-X-G motif; other site 911045011333 Response regulator receiver domain; Region: Response_reg; pfam00072 911045011334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045011335 active site 911045011336 phosphorylation site [posttranslational modification] 911045011337 intermolecular recognition site; other site 911045011338 dimerization interface [polypeptide binding]; other site 911045011339 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 911045011340 putative binding surface; other site 911045011341 active site 911045011342 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 911045011343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045011344 active site 911045011345 phosphorylation site [posttranslational modification] 911045011346 intermolecular recognition site; other site 911045011347 dimerization interface [polypeptide binding]; other site 911045011348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045011349 DNA binding site [nucleotide binding] 911045011350 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 911045011351 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 911045011352 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 911045011353 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 911045011354 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 911045011355 molybdopterin cofactor binding site [chemical binding]; other site 911045011356 substrate binding site [chemical binding]; other site 911045011357 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 911045011358 molybdopterin cofactor binding site; other site 911045011359 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 911045011360 Na2 binding site [ion binding]; other site 911045011361 putative substrate binding site 1 [chemical binding]; other site 911045011362 Na binding site 1 [ion binding]; other site 911045011363 putative substrate binding site 2 [chemical binding]; other site 911045011364 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 911045011365 Na2 binding site [ion binding]; other site 911045011366 putative substrate binding site 1 [chemical binding]; other site 911045011367 Na binding site 1 [ion binding]; other site 911045011368 putative substrate binding site 2 [chemical binding]; other site 911045011369 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 911045011370 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 911045011371 FMN binding site [chemical binding]; other site 911045011372 substrate binding site [chemical binding]; other site 911045011373 putative catalytic residue [active] 911045011374 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045011375 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 911045011376 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045011377 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045011378 DNA binding site [nucleotide binding] 911045011379 domain linker motif; other site 911045011380 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045011381 ligand binding site [chemical binding]; other site 911045011382 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045011383 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045011384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045011385 dimer interface [polypeptide binding]; other site 911045011386 conserved gate region; other site 911045011387 putative PBP binding loops; other site 911045011388 ABC-ATPase subunit interface; other site 911045011389 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045011390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045011391 dimer interface [polypeptide binding]; other site 911045011392 conserved gate region; other site 911045011393 putative PBP binding loops; other site 911045011394 ABC-ATPase subunit interface; other site 911045011395 alpha-glucosidase; Provisional; Region: PRK10137 911045011396 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 911045011397 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045011398 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045011399 Walker A/P-loop; other site 911045011400 ATP binding site [chemical binding]; other site 911045011401 Q-loop/lid; other site 911045011402 ABC transporter signature motif; other site 911045011403 Walker B; other site 911045011404 D-loop; other site 911045011405 H-loop/switch region; other site 911045011406 TOBE domain; Region: TOBE_2; pfam08402 911045011407 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 911045011408 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 911045011409 ATP-NAD kinase; Region: NAD_kinase; pfam01513 911045011410 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 911045011411 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 911045011412 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 911045011413 N-acetyl-D-glucosamine binding site [chemical binding]; other site 911045011414 catalytic residue [active] 911045011415 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 911045011416 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 911045011417 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 911045011418 putative FMN binding site [chemical binding]; other site 911045011419 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 911045011420 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 911045011421 putative acyl-acceptor binding pocket; other site 911045011422 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 911045011423 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 911045011424 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 911045011425 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 911045011426 active site 911045011427 dimer interface [polypeptide binding]; other site 911045011428 motif 1; other site 911045011429 motif 2; other site 911045011430 motif 3; other site 911045011431 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 911045011432 anticodon binding site; other site 911045011433 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 911045011434 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045011435 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 911045011436 hypothetical protein; Provisional; Region: PRK11281 911045011437 hypothetical protein; Validated; Region: PRK00041 911045011438 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 911045011439 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 911045011440 trimerization site [polypeptide binding]; other site 911045011441 active site 911045011442 GTP cyclohydrolase I; Provisional; Region: PLN03044 911045011443 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 911045011444 active site 911045011445 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 911045011446 hypothetical protein; Provisional; Region: PRK10279 911045011447 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 911045011448 nucleophile elbow; other site 911045011449 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 911045011450 FOG: CBS domain [General function prediction only]; Region: COG0517 911045011451 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 911045011452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 911045011453 PAS domain; Region: PAS_5; pfam07310 911045011454 PilZ domain; Region: PilZ; pfam07238 911045011455 PilZ domain; Region: PilZ; pfam07238 911045011456 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 911045011457 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 911045011458 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 911045011459 trimer interface [polypeptide binding]; other site 911045011460 putative metal binding site [ion binding]; other site 911045011461 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 911045011462 serine acetyltransferase; Provisional; Region: cysE; PRK11132 911045011463 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 911045011464 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 911045011465 trimer interface [polypeptide binding]; other site 911045011466 active site 911045011467 substrate binding site [chemical binding]; other site 911045011468 CoA binding site [chemical binding]; other site 911045011469 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 911045011470 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045011471 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 911045011472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 911045011473 salicylate hydroxylase; Provisional; Region: PRK08163 911045011474 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 911045011475 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 911045011476 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 911045011477 putative MPT binding site; other site 911045011478 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045011479 active site 911045011480 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 911045011481 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 911045011482 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 911045011483 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 911045011484 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 911045011485 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 911045011486 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 911045011487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045011488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045011489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045011490 dimerization interface [polypeptide binding]; other site 911045011491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 911045011492 methionine aminopeptidase; Provisional; Region: PRK12318 911045011493 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 911045011494 active site 911045011495 hypothetical protein; Reviewed; Region: PRK00024 911045011496 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 911045011497 MPN+ (JAMM) motif; other site 911045011498 Zinc-binding site [ion binding]; other site 911045011499 CHASE4 domain; Region: CHASE4; cl01308 911045011500 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045011501 metal binding site [ion binding]; metal-binding site 911045011502 active site 911045011503 I-site; other site 911045011504 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045011505 ArgK protein; Region: ArgK; pfam03308 911045011506 Protein of unknown function, DUF258; Region: DUF258; pfam03193 911045011507 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 911045011508 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 911045011509 G4 box; other site 911045011510 G5 box; other site 911045011511 pyruvate phosphate dikinase; Provisional; Region: PRK09279 911045011512 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 911045011513 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 911045011514 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 911045011515 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 911045011516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045011517 binding surface 911045011518 TPR motif; other site 911045011519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045011520 binding surface 911045011521 TPR motif; other site 911045011522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045011523 binding surface 911045011524 TPR motif; other site 911045011525 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 911045011526 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 911045011527 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 911045011528 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 911045011529 tetramer interface [polypeptide binding]; other site 911045011530 heme binding pocket [chemical binding]; other site 911045011531 NADPH binding site [chemical binding]; other site 911045011532 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 911045011533 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 911045011534 substrate binding pocket [chemical binding]; other site 911045011535 chain length determination region; other site 911045011536 substrate-Mg2+ binding site; other site 911045011537 catalytic residues [active] 911045011538 aspartate-rich region 1; other site 911045011539 active site lid residues [active] 911045011540 aspartate-rich region 2; other site 911045011541 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 911045011542 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 911045011543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045011544 S-adenosylmethionine binding site [chemical binding]; other site 911045011545 MoxR-like ATPases [General function prediction only]; Region: COG0714 911045011546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045011547 Walker A motif; other site 911045011548 ATP binding site [chemical binding]; other site 911045011549 Walker B motif; other site 911045011550 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 911045011551 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 911045011552 metal ion-dependent adhesion site (MIDAS); other site 911045011553 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 911045011554 metal binding site [ion binding]; metal-binding site 911045011555 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 911045011556 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 911045011557 active site 1 [active] 911045011558 dimer interface [polypeptide binding]; other site 911045011559 hexamer interface [polypeptide binding]; other site 911045011560 active site 2 [active] 911045011561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045011562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045011563 dimerization interface [polypeptide binding]; other site 911045011564 Protease inhibitor Inh; Region: Inh; pfam02974 911045011565 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 911045011566 putative hydrophobic ligand binding site [chemical binding]; other site 911045011567 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 911045011568 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 911045011569 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 911045011570 dimerization interface [polypeptide binding]; other site 911045011571 ligand binding site [chemical binding]; other site 911045011572 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045011573 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 911045011574 Walker A/P-loop; other site 911045011575 ATP binding site [chemical binding]; other site 911045011576 Q-loop/lid; other site 911045011577 ABC transporter signature motif; other site 911045011578 Walker B; other site 911045011579 D-loop; other site 911045011580 H-loop/switch region; other site 911045011581 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045011582 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 911045011583 Walker A/P-loop; other site 911045011584 ATP binding site [chemical binding]; other site 911045011585 Q-loop/lid; other site 911045011586 ABC transporter signature motif; other site 911045011587 Walker B; other site 911045011588 D-loop; other site 911045011589 H-loop/switch region; other site 911045011590 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 911045011591 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 911045011592 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045011593 TM-ABC transporter signature motif; other site 911045011594 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045011595 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045011596 TM-ABC transporter signature motif; other site 911045011597 Flavin Reductases; Region: FlaRed; cl00801 911045011598 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 911045011599 putative active site pocket [active] 911045011600 cleavage site 911045011601 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045011602 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045011603 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045011604 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045011605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045011606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045011607 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 911045011608 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 911045011609 dimer interface [polypeptide binding]; other site 911045011610 PYR/PP interface [polypeptide binding]; other site 911045011611 TPP binding site [chemical binding]; other site 911045011612 substrate binding site [chemical binding]; other site 911045011613 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 911045011614 TPP-binding site; other site 911045011615 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 911045011616 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045011617 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045011618 putative DNA binding site [nucleotide binding]; other site 911045011619 putative Zn2+ binding site [ion binding]; other site 911045011620 AsnC family; Region: AsnC_trans_reg; pfam01037 911045011621 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 911045011622 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 911045011623 substrate binding site [chemical binding]; other site 911045011624 hexamer interface [polypeptide binding]; other site 911045011625 metal binding site [ion binding]; metal-binding site 911045011626 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 911045011627 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 911045011628 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 911045011629 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 911045011630 ATP binding site [chemical binding]; other site 911045011631 active site 911045011632 substrate binding site [chemical binding]; other site 911045011633 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 911045011634 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 911045011635 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 911045011636 putative active site [active] 911045011637 catalytic triad [active] 911045011638 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 911045011639 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 911045011640 Chromate transporter; Region: Chromate_transp; pfam02417 911045011641 Cupin; Region: Cupin_6; pfam12852 911045011642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045011643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045011644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045011645 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 911045011646 putative catalytic residues [active] 911045011647 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 911045011648 HlyD family secretion protein; Region: HlyD; pfam00529 911045011649 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 911045011650 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045011651 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 911045011652 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 911045011653 dimerization interface [polypeptide binding]; other site 911045011654 ATP binding site [chemical binding]; other site 911045011655 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 911045011656 dimerization interface [polypeptide binding]; other site 911045011657 ATP binding site [chemical binding]; other site 911045011658 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 911045011659 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 911045011660 putative GSH binding site [chemical binding]; other site 911045011661 catalytic residues [active] 911045011662 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 911045011663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045011664 motif II; other site 911045011665 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 911045011666 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 911045011667 Ligand Binding Site [chemical binding]; other site 911045011668 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 911045011669 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 911045011670 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045011671 RNA binding surface [nucleotide binding]; other site 911045011672 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 911045011673 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 911045011674 glutamate racemase; Provisional; Region: PRK00865 911045011675 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 911045011676 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 911045011677 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 911045011678 Protein of unknown function (DUF2585); Region: DUF2585; pfam10755 911045011679 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 911045011680 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 911045011681 dimer interface [polypeptide binding]; other site 911045011682 active site 911045011683 isocitrate dehydrogenase; Validated; Region: PRK08299 911045011684 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 911045011685 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 911045011686 putative active site [active] 911045011687 catalytic site [active] 911045011688 putative metal binding site [ion binding]; other site 911045011689 Ion transport protein; Region: Ion_trans; pfam00520 911045011690 Ion channel; Region: Ion_trans_2; pfam07885 911045011691 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045011692 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045011693 ligand binding site [chemical binding]; other site 911045011694 flexible hinge region; other site 911045011695 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 911045011696 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 911045011697 motif 1; other site 911045011698 active site 911045011699 motif 2; other site 911045011700 motif 3; other site 911045011701 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 911045011702 recombinase A; Provisional; Region: recA; PRK09354 911045011703 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 911045011704 hexamer interface [polypeptide binding]; other site 911045011705 Walker A motif; other site 911045011706 ATP binding site [chemical binding]; other site 911045011707 Walker B motif; other site 911045011708 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045011709 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 911045011710 substrate binding site [chemical binding]; other site 911045011711 ATP binding site [chemical binding]; other site 911045011712 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 911045011713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045011714 PAS domain; Region: PAS_9; pfam13426 911045011715 putative active site [active] 911045011716 heme pocket [chemical binding]; other site 911045011717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045011718 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 911045011719 putative active site [active] 911045011720 heme pocket [chemical binding]; other site 911045011721 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 911045011722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045011723 dimer interface [polypeptide binding]; other site 911045011724 phosphorylation site [posttranslational modification] 911045011725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045011726 ATP binding site [chemical binding]; other site 911045011727 Mg2+ binding site [ion binding]; other site 911045011728 G-X-G motif; other site 911045011729 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 911045011730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045011731 active site 911045011732 phosphorylation site [posttranslational modification] 911045011733 intermolecular recognition site; other site 911045011734 dimerization interface [polypeptide binding]; other site 911045011735 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 911045011736 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 911045011737 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 911045011738 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 911045011739 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 911045011740 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 911045011741 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 911045011742 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 911045011743 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 911045011744 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 911045011745 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 911045011746 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 911045011747 Uncharacterized conserved protein [Function unknown]; Region: COG3334 911045011748 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 911045011749 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 911045011750 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785 911045011751 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 911045011752 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 911045011753 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 911045011754 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 911045011755 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 911045011756 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 911045011757 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 911045011758 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 911045011759 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 911045011760 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 911045011761 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 911045011762 Protein of unknown function (DUF3292); Region: DUF3292; pfam11696 911045011763 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 911045011764 Class II flagellar assembly regulator; Region: FliX; pfam10768 911045011765 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 911045011766 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 911045011767 Rod binding protein; Region: Rod-binding; cl01626 911045011768 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 911045011769 Flagellar protein FlbT; Region: FlbT; cl11455 911045011770 Flagellar protein FlaF; Region: FlaF; cl11454 911045011771 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 911045011772 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 911045011773 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 911045011774 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 911045011775 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 911045011776 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 911045011777 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 911045011778 Ubiquitin-activating enzyme e1 C-terminal domain; Region: UBA_e1_C; cl09615 911045011779 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 911045011780 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 911045011781 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 911045011782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045011783 Walker A motif; other site 911045011784 ATP binding site [chemical binding]; other site 911045011785 Walker B motif; other site 911045011786 arginine finger; other site 911045011787 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045011788 catalytic core [active] 911045011789 YcjX-like family, DUF463; Region: DUF463; pfam04317 911045011790 hypothetical protein; Provisional; Region: PRK05415 911045011791 Domain of unknown function (DUF697); Region: DUF697; cl12064 911045011792 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 911045011793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 911045011794 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 911045011795 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045011796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045011797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045011798 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045011799 putative substrate translocation pore; other site 911045011800 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 911045011801 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045011802 catalytic loop [active] 911045011803 iron binding site [ion binding]; other site 911045011804 Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513 911045011805 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 911045011806 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 911045011807 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 911045011808 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045011809 Protein of unknown function (DUF330); Region: DUF330; cl01135 911045011810 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 911045011811 mce related protein; Region: MCE; pfam02470 911045011812 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 911045011813 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 911045011814 Walker A/P-loop; other site 911045011815 ATP binding site [chemical binding]; other site 911045011816 Q-loop/lid; other site 911045011817 ABC transporter signature motif; other site 911045011818 Walker B; other site 911045011819 D-loop; other site 911045011820 H-loop/switch region; other site 911045011821 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 911045011822 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 911045011823 Permease; Region: Permease; pfam02405 911045011824 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 911045011825 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 911045011826 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 911045011827 active site 911045011828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045011829 sugar efflux transporter; Region: 2A0120; TIGR00899 911045011830 putative substrate translocation pore; other site 911045011831 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 911045011832 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045011833 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045011834 tetramer interface [polypeptide binding]; other site 911045011835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045011836 catalytic residue [active] 911045011837 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 911045011838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045011839 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 911045011840 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045011841 putative active site [active] 911045011842 putative metal binding site [ion binding]; other site 911045011843 short chain dehydrogenase; Provisional; Region: PRK08339 911045011844 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 911045011845 putative NAD(P) binding site [chemical binding]; other site 911045011846 putative active site [active] 911045011847 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 911045011848 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045011849 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045011850 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 911045011851 dimer interface [polypeptide binding]; other site 911045011852 substrate binding site [chemical binding]; other site 911045011853 ATP binding site [chemical binding]; other site 911045011854 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 911045011855 substrate binding site [chemical binding]; other site 911045011856 multimerization interface [polypeptide binding]; other site 911045011857 ATP binding site [chemical binding]; other site 911045011858 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045011859 AsnC family; Region: AsnC_trans_reg; pfam01037 911045011860 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 911045011861 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 911045011862 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045011863 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045011864 EamA-like transporter family; Region: EamA; pfam00892 911045011865 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 911045011866 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 911045011867 acyl-activating enzyme (AAE) consensus motif; other site 911045011868 putative AMP binding site [chemical binding]; other site 911045011869 putative active site [active] 911045011870 putative CoA binding site [chemical binding]; other site 911045011871 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 911045011872 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045011873 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 911045011874 active site 911045011875 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 911045011876 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 911045011877 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 911045011878 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 911045011879 phosphogluconate dehydratase; Validated; Region: PRK09054 911045011880 6-phosphogluconate dehydratase; Region: edd; TIGR01196 911045011881 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 911045011882 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 911045011883 active site 911045011884 intersubunit interface [polypeptide binding]; other site 911045011885 catalytic residue [active] 911045011886 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 911045011887 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 911045011888 active site 911045011889 dimer interface [polypeptide binding]; other site 911045011890 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 911045011891 dimer interface [polypeptide binding]; other site 911045011892 active site 911045011893 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 911045011894 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 911045011895 hexamer interface [polypeptide binding]; other site 911045011896 ligand binding site [chemical binding]; other site 911045011897 putative active site [active] 911045011898 NAD(P) binding site [chemical binding]; other site 911045011899 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045011900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045011901 putative DNA binding site [nucleotide binding]; other site 911045011902 putative Zn2+ binding site [ion binding]; other site 911045011903 AsnC family; Region: AsnC_trans_reg; pfam01037 911045011904 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 911045011905 hypothetical protein; Validated; Region: PRK01415 911045011906 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 911045011907 active site residue [active] 911045011908 Killing trait; Region: RebB; pfam11747 911045011909 Killing trait; Region: RebB; pfam11747 911045011910 Killing trait; Region: RebB; pfam11747 911045011911 Killing trait; Region: RebB; pfam11747 911045011912 Killing trait; Region: RebB; pfam11747 911045011913 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 911045011914 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045011915 DNA binding residues [nucleotide binding] 911045011916 Predicted ATPase [General function prediction only]; Region: COG3911 911045011917 AAA domain; Region: AAA_28; pfam13521 911045011918 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 911045011919 active site 911045011920 DNA binding site [nucleotide binding] 911045011921 Int/Topo IB signature motif; other site 911045011922 BCCT family transporter; Region: BCCT; pfam02028 911045011923 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 911045011924 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 911045011925 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 911045011926 NAD(P) binding site [chemical binding]; other site 911045011927 catalytic residues [active] 911045011928 catalytic residues [active] 911045011929 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 911045011930 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 911045011931 [2Fe-2S] cluster binding site [ion binding]; other site 911045011932 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 911045011933 alpha subunit interface [polypeptide binding]; other site 911045011934 active site 911045011935 substrate binding site [chemical binding]; other site 911045011936 Fe binding site [ion binding]; other site 911045011937 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045011938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045011939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045011940 dimerization interface [polypeptide binding]; other site 911045011941 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 911045011942 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045011943 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045011944 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 911045011945 FMN-binding pocket [chemical binding]; other site 911045011946 flavin binding motif; other site 911045011947 phosphate binding motif [ion binding]; other site 911045011948 beta-alpha-beta structure motif; other site 911045011949 NAD binding pocket [chemical binding]; other site 911045011950 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045011951 catalytic loop [active] 911045011952 iron binding site [ion binding]; other site 911045011953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045011954 sequence-specific DNA binding site [nucleotide binding]; other site 911045011955 Acylphosphatase; Region: Acylphosphatase; cl00551 911045011956 salt bridge; other site 911045011957 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 911045011958 active site 911045011959 catalytic triad [active] 911045011960 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 911045011961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045011962 Walker A motif; other site 911045011963 ATP binding site [chemical binding]; other site 911045011964 Walker B motif; other site 911045011965 arginine finger; other site 911045011966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 911045011967 Integrase core domain; Region: rve; pfam00665 911045011968 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 911045011969 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 911045011970 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 911045011971 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 911045011972 Ion channel; Region: Ion_trans_2; pfam07885 911045011973 TrkA-N domain; Region: TrkA_N; pfam02254 911045011974 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 911045011975 Predicted membrane protein [Function unknown]; Region: COG3766 911045011976 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 911045011977 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 911045011978 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 911045011979 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 911045011980 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045011981 PYR/PP interface [polypeptide binding]; other site 911045011982 dimer interface [polypeptide binding]; other site 911045011983 TPP binding site [chemical binding]; other site 911045011984 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 911045011985 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 911045011986 TPP-binding site [chemical binding]; other site 911045011987 dimer interface [polypeptide binding]; other site 911045011988 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 911045011989 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 911045011990 putative valine binding site [chemical binding]; other site 911045011991 dimer interface [polypeptide binding]; other site 911045011992 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 911045011993 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 911045011994 hydrophilic channel; other site 911045011995 active site 911045011996 catalytic residues [active] 911045011997 active site lid [active] 911045011998 dimerization interface [polypeptide binding]; other site 911045011999 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 911045012000 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 911045012001 Omptin family; Region: Omptin; cl01886 911045012002 intracellular protease, PfpI family; Region: PfpI; TIGR01382 911045012003 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 911045012004 conserved cys residue [active] 911045012005 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 911045012006 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 911045012007 nucleophilic elbow; other site 911045012008 catalytic triad; other site 911045012009 Sulphur transport; Region: Sulf_transp; pfam04143 911045012010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045012011 ketol-acid reductoisomerase; Provisional; Region: PRK05479 911045012012 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 911045012013 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 911045012014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045012015 sugar efflux transporter; Region: 2A0120; TIGR00899 911045012016 putative substrate translocation pore; other site 911045012017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045012018 sugar efflux transporter; Region: 2A0120; TIGR00899 911045012019 putative substrate translocation pore; other site 911045012020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045012021 Coenzyme A binding pocket [chemical binding]; other site 911045012022 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045012023 Sel1-like repeats; Region: SEL1; smart00671 911045012024 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045012025 Sel1-like repeats; Region: SEL1; smart00671 911045012026 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045012027 Sel1-like repeats; Region: SEL1; smart00671 911045012028 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045012029 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045012030 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 911045012031 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045012032 Sel1-like repeats; Region: SEL1; smart00671 911045012033 Sel1-like repeats; Region: SEL1; smart00671 911045012034 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045012035 Sel1-like repeats; Region: SEL1; smart00671 911045012036 Sel1-like repeats; Region: SEL1; smart00671 911045012037 Sel1-like repeats; Region: SEL1; smart00671 911045012038 Sel1-like repeats; Region: SEL1; smart00671 911045012039 Sel1-like repeats; Region: SEL1; smart00671 911045012040 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045012041 Sel1-like repeats; Region: SEL1; smart00671 911045012042 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045012043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045012044 Coenzyme A binding pocket [chemical binding]; other site 911045012045 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 911045012046 nudix motif; other site 911045012047 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 911045012048 2-isopropylmalate synthase; Validated; Region: PRK00915 911045012049 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 911045012050 active site 911045012051 catalytic residues [active] 911045012052 metal binding site [ion binding]; metal-binding site 911045012053 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 911045012054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045012055 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045012056 Coenzyme A binding pocket [chemical binding]; other site 911045012057 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 911045012058 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 911045012059 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 911045012060 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 911045012061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045012062 motif II; other site 911045012063 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 911045012064 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 911045012065 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045012066 protein binding site [polypeptide binding]; other site 911045012067 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 911045012068 protein binding site [polypeptide binding]; other site 911045012069 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 911045012070 HflC protein; Region: hflC; TIGR01932 911045012071 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 911045012072 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 911045012073 HflK protein; Region: hflK; TIGR01933 911045012074 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 911045012075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045012076 Coenzyme A binding pocket [chemical binding]; other site 911045012077 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 911045012078 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 911045012079 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 911045012080 folate binding site [chemical binding]; other site 911045012081 NADP+ binding site [chemical binding]; other site 911045012082 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 911045012083 catalytic core [active] 911045012084 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 911045012085 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045012086 active site 911045012087 thymidylate synthase; Reviewed; Region: thyA; PRK01827 911045012088 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 911045012089 dimerization interface [polypeptide binding]; other site 911045012090 active site 911045012091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 911045012092 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 911045012093 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 911045012094 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 911045012095 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 911045012096 FAD binding domain; Region: FAD_binding_4; pfam01565 911045012097 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 911045012098 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 911045012099 Cl- selectivity filter; other site 911045012100 Cl- binding residues [ion binding]; other site 911045012101 pore gating glutamate residue; other site 911045012102 dimer interface [polypeptide binding]; other site 911045012103 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 911045012104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045012105 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045012106 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045012107 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 911045012108 Predicted membrane protein [Function unknown]; Region: COG4541 911045012109 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045012110 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045012111 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045012112 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 911045012113 active site 911045012114 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 911045012115 Methyltransferase domain; Region: Methyltransf_18; pfam12847 911045012116 S-adenosylmethionine binding site [chemical binding]; other site 911045012117 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 911045012118 TrkA-N domain; Region: TrkA_N; pfam02254 911045012119 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 911045012120 Part of AAA domain; Region: AAA_19; pfam13245 911045012121 Family description; Region: UvrD_C_2; pfam13538 911045012122 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 911045012123 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 911045012124 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 911045012125 nucleotide binding pocket [chemical binding]; other site 911045012126 K-X-D-G motif; other site 911045012127 catalytic site [active] 911045012128 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 911045012129 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 911045012130 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 911045012131 Dimer interface [polypeptide binding]; other site 911045012132 BRCT sequence motif; other site 911045012133 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 911045012134 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045012135 dimerization interface [polypeptide binding]; other site 911045012136 putative DNA binding site [nucleotide binding]; other site 911045012137 putative Zn2+ binding site [ion binding]; other site 911045012138 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 911045012139 putative hydrophobic ligand binding site [chemical binding]; other site 911045012140 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 911045012141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045012142 Walker A/P-loop; other site 911045012143 ATP binding site [chemical binding]; other site 911045012144 Q-loop/lid; other site 911045012145 ABC transporter signature motif; other site 911045012146 Walker B; other site 911045012147 D-loop; other site 911045012148 H-loop/switch region; other site 911045012149 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 911045012150 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 911045012151 active site 911045012152 ATP binding site [chemical binding]; other site 911045012153 Phosphotransferase enzyme family; Region: APH; pfam01636 911045012154 antibiotic binding site [chemical binding]; other site 911045012155 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 911045012156 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 911045012157 Walker A/P-loop; other site 911045012158 ATP binding site [chemical binding]; other site 911045012159 Q-loop/lid; other site 911045012160 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 911045012161 Q-loop/lid; other site 911045012162 ABC transporter signature motif; other site 911045012163 Walker B; other site 911045012164 D-loop; other site 911045012165 H-loop/switch region; other site 911045012166 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 911045012167 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 911045012168 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 911045012169 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 911045012170 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 911045012171 nucleotide binding site [chemical binding]; other site 911045012172 SulA interaction site; other site 911045012173 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 911045012174 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 911045012175 Cell division protein FtsA; Region: FtsA; smart00842 911045012176 Cell division protein FtsA; Region: FtsA; pfam14450 911045012177 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 911045012178 Cell division protein FtsQ; Region: FtsQ; pfam03799 911045012179 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 911045012180 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 911045012181 ATP-grasp domain; Region: ATP-grasp_4; cl17255 911045012182 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 911045012183 FAD binding domain; Region: FAD_binding_4; pfam01565 911045012184 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 911045012185 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 911045012186 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 911045012187 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 911045012188 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 911045012189 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 911045012190 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 911045012191 active site 911045012192 homodimer interface [polypeptide binding]; other site 911045012193 cell division protein FtsW; Region: ftsW; TIGR02614 911045012194 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 911045012195 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 911045012196 NAD(P) binding pocket [chemical binding]; other site 911045012197 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 911045012198 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 911045012199 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 911045012200 Mg++ binding site [ion binding]; other site 911045012201 putative catalytic motif [active] 911045012202 putative substrate binding site [chemical binding]; other site 911045012203 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 911045012204 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 911045012205 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 911045012206 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 911045012207 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 911045012208 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 911045012209 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 911045012210 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 911045012211 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 911045012212 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 911045012213 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 911045012214 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 911045012215 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 911045012216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045012217 S-adenosylmethionine binding site [chemical binding]; other site 911045012218 cell division protein MraZ; Reviewed; Region: PRK00326 911045012219 MraZ protein; Region: MraZ; pfam02381 911045012220 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 911045012221 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 911045012222 Metal-binding active site; metal-binding site 911045012223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045012224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045012225 putative substrate translocation pore; other site 911045012226 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 911045012227 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 911045012228 DNA binding residues [nucleotide binding] 911045012229 putative dimer interface [polypeptide binding]; other site 911045012230 putative metal binding residues [ion binding]; other site 911045012231 peptidase T; Region: peptidase-T; TIGR01882 911045012232 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 911045012233 metal binding site [ion binding]; metal-binding site 911045012234 dimer interface [polypeptide binding]; other site 911045012235 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045012236 Uncharacterized conserved protein [Function unknown]; Region: COG1262 911045012237 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 911045012238 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 911045012239 classical (c) SDRs; Region: SDR_c; cd05233 911045012240 NAD(P) binding site [chemical binding]; other site 911045012241 active site 911045012242 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 911045012243 putative hydrophobic ligand binding site [chemical binding]; other site 911045012244 protein interface [polypeptide binding]; other site 911045012245 gate; other site 911045012246 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 911045012247 Prostaglandin dehydrogenases; Region: PGDH; cd05288 911045012248 NAD(P) binding site [chemical binding]; other site 911045012249 substrate binding site [chemical binding]; other site 911045012250 dimer interface [polypeptide binding]; other site 911045012251 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 911045012252 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 911045012253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045012254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045012255 homodimer interface [polypeptide binding]; other site 911045012256 catalytic residue [active] 911045012257 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 911045012258 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 911045012259 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 911045012260 N-acetyl-D-glucosamine binding site [chemical binding]; other site 911045012261 catalytic residue [active] 911045012262 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 911045012263 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 911045012264 amidase catalytic site [active] 911045012265 Zn binding residues [ion binding]; other site 911045012266 substrate binding site [chemical binding]; other site 911045012267 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 911045012268 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 911045012269 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 911045012270 putative metal binding site [ion binding]; other site 911045012271 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 911045012272 HSP70 interaction site [polypeptide binding]; other site 911045012273 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 911045012274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045012275 metal binding site [ion binding]; metal-binding site 911045012276 active site 911045012277 I-site; other site 911045012278 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045012279 5-oxoprolinase; Region: PLN02666 911045012280 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 911045012281 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 911045012282 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 911045012283 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 911045012284 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 911045012285 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 911045012286 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045012287 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045012288 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045012289 active site 911045012290 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045012291 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045012292 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 911045012293 putative N-terminal domain interface [polypeptide binding]; other site 911045012294 putative dimer interface [polypeptide binding]; other site 911045012295 putative substrate binding pocket (H-site) [chemical binding]; other site 911045012296 Methyltransferase domain; Region: Methyltransf_31; pfam13847 911045012297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045012298 S-adenosylmethionine binding site [chemical binding]; other site 911045012299 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 911045012300 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 911045012301 BA14K-like protein; Region: BA14K; pfam07886 911045012302 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 911045012303 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 911045012304 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045012305 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 911045012306 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 911045012307 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 911045012308 substrate binding pocket [chemical binding]; other site 911045012309 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 911045012310 B12 binding site [chemical binding]; other site 911045012311 cobalt ligand [ion binding]; other site 911045012312 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 911045012313 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 911045012314 FAD binding site [chemical binding]; other site 911045012315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045012316 putative DNA binding site [nucleotide binding]; other site 911045012317 putative Zn2+ binding site [ion binding]; other site 911045012318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045012319 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 911045012320 Mechanosensitive ion channel; Region: MS_channel; pfam00924 911045012321 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 911045012322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045012323 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 911045012324 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 911045012325 dimerization interface [polypeptide binding]; other site 911045012326 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045012327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045012328 DNA binding residues [nucleotide binding] 911045012329 dimerization interface [polypeptide binding]; other site 911045012330 Predicted transcriptional regulator [Transcription]; Region: COG2345 911045012331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045012332 metal binding site [ion binding]; metal-binding site 911045012333 active site 911045012334 I-site; other site 911045012335 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045012336 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 911045012337 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 911045012338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045012339 Walker A/P-loop; other site 911045012340 ATP binding site [chemical binding]; other site 911045012341 Q-loop/lid; other site 911045012342 ABC transporter signature motif; other site 911045012343 Walker B; other site 911045012344 D-loop; other site 911045012345 H-loop/switch region; other site 911045012346 ABC transporter; Region: ABC_tran_2; pfam12848 911045012347 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 911045012348 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 911045012349 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 911045012350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045012351 PAS domain; Region: PAS_9; pfam13426 911045012352 putative active site [active] 911045012353 heme pocket [chemical binding]; other site 911045012354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 911045012355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045012356 metal binding site [ion binding]; metal-binding site 911045012357 active site 911045012358 I-site; other site 911045012359 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045012360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045012361 AAA domain; Region: AAA_23; pfam13476 911045012362 Walker A/P-loop; other site 911045012363 ATP binding site [chemical binding]; other site 911045012364 Q-loop/lid; other site 911045012365 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 911045012366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045012367 ABC transporter signature motif; other site 911045012368 Walker B; other site 911045012369 D-loop; other site 911045012370 H-loop/switch region; other site 911045012371 exonuclease subunit SbcD; Provisional; Region: PRK10966 911045012372 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 911045012373 active site 911045012374 metal binding site [ion binding]; metal-binding site 911045012375 DNA binding site [nucleotide binding] 911045012376 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 911045012377 Pirin; Region: Pirin; pfam02678 911045012378 Pirin-related protein [General function prediction only]; Region: COG1741 911045012379 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045012380 putative DNA binding site [nucleotide binding]; other site 911045012381 putative Zn2+ binding site [ion binding]; other site 911045012382 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 911045012383 ArsC family; Region: ArsC; pfam03960 911045012384 catalytic residues [active] 911045012385 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 911045012386 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 911045012387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045012388 Coenzyme A binding pocket [chemical binding]; other site 911045012389 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 911045012390 nucleotide binding site [chemical binding]; other site 911045012391 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 911045012392 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; pfam10614 911045012393 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 911045012394 Domain of unknown function DUF20; Region: UPF0118; pfam01594 911045012395 Uncharacterized conserved protein [Function unknown]; Region: COG2968 911045012396 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 911045012397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045012398 putative substrate translocation pore; other site 911045012399 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 911045012400 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045012401 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 911045012402 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 911045012403 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 911045012404 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 911045012405 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 911045012406 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 911045012407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045012408 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 911045012409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045012410 DNA binding residues [nucleotide binding] 911045012411 CHC2 zinc finger; Region: zf-CHC2; cl17510 911045012412 DNA primase; Validated; Region: dnaG; PRK05667 911045012413 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 911045012414 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 911045012415 active site 911045012416 metal binding site [ion binding]; metal-binding site 911045012417 interdomain interaction site; other site 911045012418 Yqey-like protein; Region: YqeY; cl17540 911045012419 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 911045012420 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 911045012421 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 911045012422 catalytic site [active] 911045012423 subunit interface [polypeptide binding]; other site 911045012424 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045012425 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 911045012426 DNA binding residues [nucleotide binding] 911045012427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045012428 sequence-specific DNA binding site [nucleotide binding]; other site 911045012429 salt bridge; other site 911045012430 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 911045012431 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045012432 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 911045012433 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 911045012434 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045012435 ATP-grasp domain; Region: ATP-grasp_4; cl17255 911045012436 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 911045012437 IMP binding site; other site 911045012438 dimer interface [polypeptide binding]; other site 911045012439 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 911045012440 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 911045012441 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 911045012442 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 911045012443 heme-binding site [chemical binding]; other site 911045012444 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045012445 dimer interface [polypeptide binding]; other site 911045012446 putative CheW interface [polypeptide binding]; other site 911045012447 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045012448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045012449 putative DNA binding site [nucleotide binding]; other site 911045012450 dimerization interface [polypeptide binding]; other site 911045012451 putative Zn2+ binding site [ion binding]; other site 911045012452 AsnC family; Region: AsnC_trans_reg; pfam01037 911045012453 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 911045012454 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 911045012455 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 911045012456 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 911045012457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 911045012458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045012459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045012460 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045012461 putative effector binding pocket; other site 911045012462 dimerization interface [polypeptide binding]; other site 911045012463 TMAO/DMSO reductase; Reviewed; Region: PRK05363 911045012464 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 911045012465 Moco binding site; other site 911045012466 metal coordination site [ion binding]; other site 911045012467 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 911045012468 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 911045012469 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 911045012470 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045012471 active site 911045012472 metal binding site [ion binding]; metal-binding site 911045012473 hexamer interface [polypeptide binding]; other site 911045012474 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 911045012475 nucleotide binding site/active site [active] 911045012476 HIT family signature motif; other site 911045012477 catalytic residue [active] 911045012478 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 911045012479 elongation factor G; Reviewed; Region: PRK12740 911045012480 G1 box; other site 911045012481 putative GEF interaction site [polypeptide binding]; other site 911045012482 GTP/Mg2+ binding site [chemical binding]; other site 911045012483 Switch I region; other site 911045012484 G2 box; other site 911045012485 G3 box; other site 911045012486 Switch II region; other site 911045012487 G4 box; other site 911045012488 G5 box; other site 911045012489 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 911045012490 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 911045012491 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 911045012492 Protein of unknown function (DUF992); Region: DUF992; pfam06186 911045012493 aspartate aminotransferase; Provisional; Region: PRK05764 911045012494 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045012495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045012496 homodimer interface [polypeptide binding]; other site 911045012497 catalytic residue [active] 911045012498 Predicted membrane protein [Function unknown]; Region: COG2246 911045012499 GtrA-like protein; Region: GtrA; pfam04138 911045012500 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 911045012501 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045012502 EamA-like transporter family; Region: EamA; pfam00892 911045012503 EamA-like transporter family; Region: EamA; pfam00892 911045012504 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 911045012505 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 911045012506 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 911045012507 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 911045012508 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 911045012509 excinuclease ABC subunit B; Provisional; Region: PRK05298 911045012510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045012511 ATP binding site [chemical binding]; other site 911045012512 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045012513 nucleotide binding region [chemical binding]; other site 911045012514 ATP-binding site [chemical binding]; other site 911045012515 Ultra-violet resistance protein B; Region: UvrB; pfam12344 911045012516 UvrB/uvrC motif; Region: UVR; pfam02151 911045012517 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 911045012518 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 911045012519 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 911045012520 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 911045012521 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 911045012522 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 911045012523 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 911045012524 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 911045012525 DNA-binding site [nucleotide binding]; DNA binding site 911045012526 RNA-binding motif; other site 911045012527 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 911045012528 Flavodoxin domain; Region: Flavodoxin_5; cl17428 911045012529 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045012530 putative glutathione S-transferase; Provisional; Region: PRK10357 911045012531 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 911045012532 dimer interface [polypeptide binding]; other site 911045012533 N-terminal domain interface [polypeptide binding]; other site 911045012534 putative substrate binding pocket (H-site) [chemical binding]; other site 911045012535 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045012536 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045012537 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 911045012538 dimer interface [polypeptide binding]; other site 911045012539 N-terminal domain interface [polypeptide binding]; other site 911045012540 putative substrate binding pocket (H-site) [chemical binding]; other site 911045012541 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 911045012542 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 911045012543 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 911045012544 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 911045012545 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 911045012546 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 911045012547 GIY-YIG motif/motif A; other site 911045012548 active site 911045012549 catalytic site [active] 911045012550 putative DNA binding site [nucleotide binding]; other site 911045012551 metal binding site [ion binding]; metal-binding site 911045012552 UvrB/uvrC motif; Region: UVR; pfam02151 911045012553 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 911045012554 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045012555 putative catalytic site [active] 911045012556 putative metal binding site [ion binding]; other site 911045012557 putative phosphate binding site [ion binding]; other site 911045012558 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 911045012559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045012560 motif II; other site 911045012561 thymidine kinase; Provisional; Region: PRK04296 911045012562 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 911045012563 ATP binding site [chemical binding]; other site 911045012564 Walker A motif; other site 911045012565 Walker B motif; other site 911045012566 Transcriptional activator HlyU; Region: HlyU; pfam10115 911045012567 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 911045012568 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 911045012569 MoaE interaction surface [polypeptide binding]; other site 911045012570 MoeB interaction surface [polypeptide binding]; other site 911045012571 thiocarboxylated glycine; other site 911045012572 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 911045012573 MoaE homodimer interface [polypeptide binding]; other site 911045012574 MoaD interaction [polypeptide binding]; other site 911045012575 active site residues [active] 911045012576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045012577 putative substrate translocation pore; other site 911045012578 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 911045012579 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 911045012580 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 911045012581 homodimer interface [polypeptide binding]; other site 911045012582 substrate-cofactor binding pocket; other site 911045012583 catalytic residue [active] 911045012584 Transcriptional regulators [Transcription]; Region: MarR; COG1846 911045012585 MarR family; Region: MarR_2; pfam12802 911045012586 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 911045012587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012588 active site 911045012589 phosphorylation site [posttranslational modification] 911045012590 intermolecular recognition site; other site 911045012591 dimerization interface [polypeptide binding]; other site 911045012592 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045012593 DNA binding site [nucleotide binding] 911045012594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045012595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045012596 dimerization interface [polypeptide binding]; other site 911045012597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045012598 dimer interface [polypeptide binding]; other site 911045012599 phosphorylation site [posttranslational modification] 911045012600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045012601 ATP binding site [chemical binding]; other site 911045012602 Mg2+ binding site [ion binding]; other site 911045012603 G-X-G motif; other site 911045012604 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 911045012605 dimer interface [polypeptide binding]; other site 911045012606 putative tRNA-binding site [nucleotide binding]; other site 911045012607 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 911045012608 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 911045012609 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 911045012610 Membrane fusogenic activity; Region: BMFP; pfam04380 911045012611 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 911045012612 Uncharacterized conserved protein [Function unknown]; Region: COG1565 911045012613 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 911045012614 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 911045012615 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045012616 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045012617 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 911045012618 active site 911045012619 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 911045012620 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 911045012621 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045012622 active site 911045012623 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 911045012624 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 911045012625 5S rRNA interface [nucleotide binding]; other site 911045012626 CTC domain interface [polypeptide binding]; other site 911045012627 L16 interface [polypeptide binding]; other site 911045012628 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 911045012629 putative active site [active] 911045012630 catalytic residue [active] 911045012631 GTP-binding protein YchF; Reviewed; Region: PRK09601 911045012632 YchF GTPase; Region: YchF; cd01900 911045012633 G1 box; other site 911045012634 GTP/Mg2+ binding site [chemical binding]; other site 911045012635 Switch I region; other site 911045012636 G2 box; other site 911045012637 Switch II region; other site 911045012638 G3 box; other site 911045012639 G4 box; other site 911045012640 G5 box; other site 911045012641 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 911045012642 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 911045012643 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 911045012644 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 911045012645 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 911045012646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045012647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045012648 Coenzyme A binding pocket [chemical binding]; other site 911045012649 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 911045012650 putative FMN binding site [chemical binding]; other site 911045012651 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 911045012652 active site 911045012653 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 911045012654 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 911045012655 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 911045012656 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 911045012657 cytochrome b; Provisional; Region: CYTB; MTH00156 911045012658 Qi binding site; other site 911045012659 intrachain domain interface; other site 911045012660 interchain domain interface [polypeptide binding]; other site 911045012661 heme bH binding site [chemical binding]; other site 911045012662 heme bL binding site [chemical binding]; other site 911045012663 Qo binding site; other site 911045012664 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 911045012665 interchain domain interface [polypeptide binding]; other site 911045012666 intrachain domain interface; other site 911045012667 Qi binding site; other site 911045012668 Qo binding site; other site 911045012669 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 911045012670 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 911045012671 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 911045012672 [2Fe-2S] cluster binding site [ion binding]; other site 911045012673 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 911045012674 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045012675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045012676 Walker A/P-loop; other site 911045012677 ATP binding site [chemical binding]; other site 911045012678 Q-loop/lid; other site 911045012679 ABC transporter signature motif; other site 911045012680 Walker B; other site 911045012681 D-loop; other site 911045012682 H-loop/switch region; other site 911045012683 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 911045012684 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 911045012685 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 911045012686 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 911045012687 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 911045012688 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 911045012689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045012690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045012691 fumarate hydratase; Reviewed; Region: fumC; PRK00485 911045012692 Class II fumarases; Region: Fumarase_classII; cd01362 911045012693 active site 911045012694 tetramer interface [polypeptide binding]; other site 911045012695 Predicted ATPase [General function prediction only]; Region: COG4637 911045012696 PAS domain S-box; Region: sensory_box; TIGR00229 911045012697 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045012698 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045012699 putative Zn2+ binding site [ion binding]; other site 911045012700 putative DNA binding site [nucleotide binding]; other site 911045012701 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 911045012702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 911045012703 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 911045012704 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 911045012705 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 911045012706 active site 911045012707 NTP binding site [chemical binding]; other site 911045012708 metal binding triad [ion binding]; metal-binding site 911045012709 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 911045012710 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 911045012711 putative active site [active] 911045012712 putative CoA binding site [chemical binding]; other site 911045012713 nudix motif; other site 911045012714 metal binding site [ion binding]; metal-binding site 911045012715 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 911045012716 MoxR-like ATPases [General function prediction only]; Region: COG0714 911045012717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 911045012718 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 911045012719 Protein of unknown function DUF58; Region: DUF58; pfam01882 911045012720 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 911045012721 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 911045012722 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 911045012723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045012724 Coenzyme A binding pocket [chemical binding]; other site 911045012725 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 911045012726 nudix motif; other site 911045012727 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 911045012728 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 911045012729 active site 911045012730 metal binding site [ion binding]; metal-binding site 911045012731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045012732 Coenzyme A binding pocket [chemical binding]; other site 911045012733 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 911045012734 FHIPEP family; Region: FHIPEP; pfam00771 911045012735 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 911045012736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045012737 Walker A motif; other site 911045012738 ATP binding site [chemical binding]; other site 911045012739 Walker B motif; other site 911045012740 arginine finger; other site 911045012741 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 911045012742 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 911045012743 flagellar assembly protein H; Validated; Region: fliH; PRK06032 911045012744 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 911045012745 FliG C-terminal domain; Region: FliG_C; pfam01706 911045012746 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 911045012747 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 911045012748 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 911045012749 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 911045012750 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 911045012751 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 911045012752 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 911045012753 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 911045012754 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 911045012755 Ligand Binding Site [chemical binding]; other site 911045012756 Protein of unknown function, DUF399; Region: DUF399; cl01139 911045012757 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 911045012758 Protein export membrane protein; Region: SecD_SecF; cl14618 911045012759 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045012760 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045012761 Outer membrane efflux protein; Region: OEP; pfam02321 911045012762 Outer membrane efflux protein; Region: OEP; pfam02321 911045012763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045012764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045012765 dimer interface [polypeptide binding]; other site 911045012766 phosphorylation site [posttranslational modification] 911045012767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045012768 ATP binding site [chemical binding]; other site 911045012769 Mg2+ binding site [ion binding]; other site 911045012770 G-X-G motif; other site 911045012771 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045012772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012773 active site 911045012774 phosphorylation site [posttranslational modification] 911045012775 intermolecular recognition site; other site 911045012776 dimerization interface [polypeptide binding]; other site 911045012777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045012778 DNA binding site [nucleotide binding] 911045012779 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045012780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045012781 dimer interface [polypeptide binding]; other site 911045012782 conserved gate region; other site 911045012783 putative PBP binding loops; other site 911045012784 ABC-ATPase subunit interface; other site 911045012785 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 911045012786 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045012787 hypothetical protein; Provisional; Region: PRK11622 911045012788 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045012789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045012790 Walker A/P-loop; other site 911045012791 ATP binding site [chemical binding]; other site 911045012792 Q-loop/lid; other site 911045012793 ABC transporter signature motif; other site 911045012794 Walker B; other site 911045012795 D-loop; other site 911045012796 H-loop/switch region; other site 911045012797 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045012798 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045012799 domain linker motif; other site 911045012800 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045012801 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 911045012802 putative active site [active] 911045012803 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 911045012804 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 911045012805 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045012806 Predicted membrane protein [Function unknown]; Region: COG4267 911045012807 TM1410 hypothetical-related protein; Region: DUF297; cl00997 911045012808 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 911045012809 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 911045012810 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 911045012811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045012812 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045012813 DNA binding residues [nucleotide binding] 911045012814 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 911045012815 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 911045012816 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 911045012817 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 911045012818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045012819 S-adenosylmethionine binding site [chemical binding]; other site 911045012820 SnoaL-like domain; Region: SnoaL_2; pfam12680 911045012821 short chain dehydrogenase; Provisional; Region: PRK07024 911045012822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012823 NAD(P) binding site [chemical binding]; other site 911045012824 active site 911045012825 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 911045012826 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 911045012827 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 911045012828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045012829 dimerization interface [polypeptide binding]; other site 911045012830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045012831 dimer interface [polypeptide binding]; other site 911045012832 phosphorylation site [posttranslational modification] 911045012833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045012834 ATP binding site [chemical binding]; other site 911045012835 Mg2+ binding site [ion binding]; other site 911045012836 G-X-G motif; other site 911045012837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012838 active site 911045012839 phosphorylation site [posttranslational modification] 911045012840 intermolecular recognition site; other site 911045012841 dimerization interface [polypeptide binding]; other site 911045012842 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 911045012843 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045012844 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 911045012845 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 911045012846 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 911045012847 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 911045012848 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 911045012849 molybdopterin cofactor binding site [chemical binding]; other site 911045012850 substrate binding site [chemical binding]; other site 911045012851 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 911045012852 molybdopterin cofactor binding site; other site 911045012853 enoyl-CoA hydratase; Validated; Region: PRK08788 911045012854 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045012855 substrate binding site [chemical binding]; other site 911045012856 oxyanion hole (OAH) forming residues; other site 911045012857 trimer interface [polypeptide binding]; other site 911045012858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045012859 dimer interface [polypeptide binding]; other site 911045012860 phosphorylation site [posttranslational modification] 911045012861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045012862 ATP binding site [chemical binding]; other site 911045012863 Mg2+ binding site [ion binding]; other site 911045012864 G-X-G motif; other site 911045012865 The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of...; Region: ML; cl00274 911045012866 Response regulator receiver domain; Region: Response_reg; pfam00072 911045012867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012868 active site 911045012869 phosphorylation site [posttranslational modification] 911045012870 intermolecular recognition site; other site 911045012871 dimerization interface [polypeptide binding]; other site 911045012872 Hpt domain; Region: Hpt; pfam01627 911045012873 Response regulator receiver domain; Region: Response_reg; pfam00072 911045012874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045012875 active site 911045012876 phosphorylation site [posttranslational modification] 911045012877 intermolecular recognition site; other site 911045012878 dimerization interface [polypeptide binding]; other site 911045012879 PAS fold; Region: PAS_4; pfam08448 911045012880 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045012881 metal binding site [ion binding]; metal-binding site 911045012882 active site 911045012883 I-site; other site 911045012884 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045012885 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045012886 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 911045012887 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045012888 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 911045012889 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 911045012890 Walker A/P-loop; other site 911045012891 ATP binding site [chemical binding]; other site 911045012892 Q-loop/lid; other site 911045012893 ABC transporter signature motif; other site 911045012894 Walker B; other site 911045012895 D-loop; other site 911045012896 H-loop/switch region; other site 911045012897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045012898 short chain dehydrogenase; Provisional; Region: PRK07024 911045012899 NAD(P) binding site [chemical binding]; other site 911045012900 active site 911045012901 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 911045012902 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 911045012903 N-terminal plug; other site 911045012904 ligand-binding site [chemical binding]; other site 911045012905 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 911045012906 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 911045012907 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 911045012908 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 911045012909 4Fe-4S binding domain; Region: Fer4_5; pfam12801 911045012910 4Fe-4S binding domain; Region: Fer4_5; pfam12801 911045012911 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 911045012912 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 911045012913 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 911045012914 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 911045012915 [4Fe-4S] binding site [ion binding]; other site 911045012916 molybdopterin cofactor binding site; other site 911045012917 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 911045012918 molybdopterin cofactor binding site; other site 911045012919 NapD protein; Region: NapD; pfam03927 911045012920 4Fe-4S binding domain; Region: Fer4; cl02805 911045012921 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 911045012922 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 911045012923 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 911045012924 metal ion-dependent adhesion site (MIDAS); other site 911045012925 MoxR-like ATPases [General function prediction only]; Region: COG0714 911045012926 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 911045012927 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 911045012928 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 911045012929 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 911045012930 Binuclear center (active site) [active] 911045012931 K-pathway; other site 911045012932 Putative proton exit pathway; other site 911045012933 Cytochrome c; Region: Cytochrom_C; pfam00034 911045012934 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045012935 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 911045012936 ligand binding site [chemical binding]; other site 911045012937 flexible hinge region; other site 911045012938 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 911045012939 putative switch regulator; other site 911045012940 non-specific DNA interactions [nucleotide binding]; other site 911045012941 DNA binding site [nucleotide binding] 911045012942 sequence specific DNA binding site [nucleotide binding]; other site 911045012943 putative cAMP binding site [chemical binding]; other site 911045012944 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 911045012945 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 911045012946 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045012947 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045012948 Walker A/P-loop; other site 911045012949 ATP binding site [chemical binding]; other site 911045012950 Q-loop/lid; other site 911045012951 ABC transporter signature motif; other site 911045012952 Walker B; other site 911045012953 D-loop; other site 911045012954 H-loop/switch region; other site 911045012955 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 911045012956 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045012957 Walker A/P-loop; other site 911045012958 ATP binding site [chemical binding]; other site 911045012959 Q-loop/lid; other site 911045012960 ABC transporter signature motif; other site 911045012961 Walker B; other site 911045012962 D-loop; other site 911045012963 H-loop/switch region; other site 911045012964 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045012965 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 911045012966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045012967 dimer interface [polypeptide binding]; other site 911045012968 conserved gate region; other site 911045012969 ABC-ATPase subunit interface; other site 911045012970 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045012971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045012972 dimer interface [polypeptide binding]; other site 911045012973 conserved gate region; other site 911045012974 putative PBP binding loops; other site 911045012975 ABC-ATPase subunit interface; other site 911045012976 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 911045012977 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045012978 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045012979 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045012980 Walker A/P-loop; other site 911045012981 ATP binding site [chemical binding]; other site 911045012982 Q-loop/lid; other site 911045012983 ABC transporter signature motif; other site 911045012984 Walker B; other site 911045012985 D-loop; other site 911045012986 H-loop/switch region; other site 911045012987 TOBE domain; Region: TOBE_2; pfam08402 911045012988 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 911045012989 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 911045012990 active site 911045012991 catalytic site [active] 911045012992 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 911045012993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045012994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045012995 dimer interface [polypeptide binding]; other site 911045012996 conserved gate region; other site 911045012997 putative PBP binding loops; other site 911045012998 ABC-ATPase subunit interface; other site 911045012999 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045013000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013001 dimer interface [polypeptide binding]; other site 911045013002 conserved gate region; other site 911045013003 putative PBP binding loops; other site 911045013004 ABC-ATPase subunit interface; other site 911045013005 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045013006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045013007 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045013008 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045013009 DNA binding site [nucleotide binding] 911045013010 domain linker motif; other site 911045013011 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 911045013012 ligand binding site [chemical binding]; other site 911045013013 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 911045013014 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 911045013015 Walker A/P-loop; other site 911045013016 ATP binding site [chemical binding]; other site 911045013017 Q-loop/lid; other site 911045013018 ABC transporter signature motif; other site 911045013019 Walker B; other site 911045013020 D-loop; other site 911045013021 H-loop/switch region; other site 911045013022 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 911045013023 FtsX-like permease family; Region: FtsX; pfam02687 911045013024 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 911045013025 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 911045013026 FtsX-like permease family; Region: FtsX; pfam02687 911045013027 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 911045013028 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045013029 Predicted transcriptional regulator [Transcription]; Region: COG2378 911045013030 HTH domain; Region: HTH_11; pfam08279 911045013031 WYL domain; Region: WYL; pfam13280 911045013032 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045013033 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045013034 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 911045013035 putative N-terminal domain interface [polypeptide binding]; other site 911045013036 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 911045013037 catalytic triad [active] 911045013038 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 911045013039 DctM-like transporters; Region: DctM; pfam06808 911045013040 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 911045013041 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 911045013042 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 911045013043 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045013044 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 911045013045 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 911045013046 active site 911045013047 dimerization interface [polypeptide binding]; other site 911045013048 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 911045013049 Putative phosphatase (DUF442); Region: DUF442; cl17385 911045013050 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 911045013051 Predicted transporter component [General function prediction only]; Region: COG2391 911045013052 Sulphur transport; Region: Sulf_transp; pfam04143 911045013053 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 911045013054 Predicted transporter component [General function prediction only]; Region: COG2391 911045013055 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045013056 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045013057 active site 911045013058 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 911045013059 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 911045013060 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 911045013061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 911045013062 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 911045013063 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045013064 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045013065 active site 911045013066 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 911045013067 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045013068 ATP-grasp domain; Region: ATP-grasp_4; cl17255 911045013069 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 911045013070 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 911045013071 carboxyltransferase (CT) interaction site; other site 911045013072 biotinylation site [posttranslational modification]; other site 911045013073 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 911045013074 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 911045013075 active site 911045013076 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 911045013077 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 911045013078 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 911045013079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013080 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045013081 NAD(P) binding site [chemical binding]; other site 911045013082 active site 911045013083 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 911045013084 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 911045013085 acyl-activating enzyme (AAE) consensus motif; other site 911045013086 putative AMP binding site [chemical binding]; other site 911045013087 putative active site [active] 911045013088 putative CoA binding site [chemical binding]; other site 911045013089 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 911045013090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045013091 substrate binding site [chemical binding]; other site 911045013092 oxyanion hole (OAH) forming residues; other site 911045013093 trimer interface [polypeptide binding]; other site 911045013094 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 911045013095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045013096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045013097 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 911045013098 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 911045013099 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 911045013100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045013101 Soluble P-type ATPase [General function prediction only]; Region: COG4087 911045013102 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 911045013103 putative FMN binding site [chemical binding]; other site 911045013104 putative dimer interface [polypeptide binding]; other site 911045013105 Cupin domain; Region: Cupin_2; pfam07883 911045013106 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 911045013107 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 911045013108 active site 911045013109 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 911045013110 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 911045013111 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 911045013112 Na binding site [ion binding]; other site 911045013113 Predicted membrane protein [Function unknown]; Region: COG3152 911045013114 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 911045013115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045013116 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 911045013117 transmembrane helices; other site 911045013118 TrkA-C domain; Region: TrkA_C; pfam02080 911045013119 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 911045013120 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 911045013121 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 911045013122 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045013123 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045013124 active site 911045013125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045013126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045013127 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045013128 putative effector binding pocket; other site 911045013129 dimerization interface [polypeptide binding]; other site 911045013130 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 911045013131 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 911045013132 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045013133 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045013134 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 911045013135 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 911045013136 inhibitor site; inhibition site 911045013137 active site 911045013138 dimer interface [polypeptide binding]; other site 911045013139 catalytic residue [active] 911045013140 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 911045013141 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 911045013142 N- and C-terminal domain interface [polypeptide binding]; other site 911045013143 active site 911045013144 MgATP binding site [chemical binding]; other site 911045013145 catalytic site [active] 911045013146 metal binding site [ion binding]; metal-binding site 911045013147 glycerol binding site [chemical binding]; other site 911045013148 homotetramer interface [polypeptide binding]; other site 911045013149 homodimer interface [polypeptide binding]; other site 911045013150 FBP binding site [chemical binding]; other site 911045013151 protein IIAGlc interface [polypeptide binding]; other site 911045013152 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 911045013153 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045013154 putative mechanosensitive channel protein; Provisional; Region: PRK11465 911045013155 Mechanosensitive ion channel; Region: MS_channel; pfam00924 911045013156 Paraquat-inducible protein A; Region: PqiA; pfam04403 911045013157 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 911045013158 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 911045013159 ATP binding site [chemical binding]; other site 911045013160 Walker B motif; other site 911045013161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045013162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045013163 active site 911045013164 phosphorylation site [posttranslational modification] 911045013165 intermolecular recognition site; other site 911045013166 dimerization interface [polypeptide binding]; other site 911045013167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045013168 DNA binding site [nucleotide binding] 911045013169 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 911045013170 homodimer interaction site [polypeptide binding]; other site 911045013171 cofactor binding site; other site 911045013172 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045013173 EamA-like transporter family; Region: EamA; pfam00892 911045013174 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045013175 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 911045013176 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 911045013177 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 911045013178 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 911045013179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045013180 active site 911045013181 phosphorylation site [posttranslational modification] 911045013182 intermolecular recognition site; other site 911045013183 dimerization interface [polypeptide binding]; other site 911045013184 CheB methylesterase; Region: CheB_methylest; pfam01339 911045013185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045013186 Response regulator receiver domain; Region: Response_reg; pfam00072 911045013187 active site 911045013188 phosphorylation site [posttranslational modification] 911045013189 intermolecular recognition site; other site 911045013190 dimerization interface [polypeptide binding]; other site 911045013191 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 911045013192 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 911045013193 putative binding surface; other site 911045013194 active site 911045013195 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 911045013196 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 911045013197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045013198 ATP binding site [chemical binding]; other site 911045013199 Mg2+ binding site [ion binding]; other site 911045013200 G-X-G motif; other site 911045013201 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 911045013202 CheW-like domain; Region: CheW; pfam01584 911045013203 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 911045013204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045013205 active site 911045013206 phosphorylation site [posttranslational modification] 911045013207 intermolecular recognition site; other site 911045013208 dimerization interface [polypeptide binding]; other site 911045013209 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 911045013210 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 911045013211 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 911045013212 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 911045013213 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 911045013214 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 911045013215 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 911045013216 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045013217 RNA binding surface [nucleotide binding]; other site 911045013218 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 911045013219 active site 911045013220 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 911045013221 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 911045013222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045013223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045013224 DNA binding residues [nucleotide binding] 911045013225 CHASE2 domain; Region: CHASE2; cl01732 911045013226 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 911045013227 cyclase homology domain; Region: CHD; cd07302 911045013228 nucleotidyl binding site; other site 911045013229 metal binding site [ion binding]; metal-binding site 911045013230 dimer interface [polypeptide binding]; other site 911045013231 NMT1/THI5 like; Region: NMT1; pfam09084 911045013232 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045013233 membrane-bound complex binding site; other site 911045013234 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 911045013235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013236 dimer interface [polypeptide binding]; other site 911045013237 conserved gate region; other site 911045013238 putative PBP binding loops; other site 911045013239 ABC-ATPase subunit interface; other site 911045013240 DNA topoisomerase 2; Provisional; Region: PLN03237 911045013241 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 911045013242 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 911045013243 GDP-binding site [chemical binding]; other site 911045013244 ACT binding site; other site 911045013245 IMP binding site; other site 911045013246 EamA-like transporter family; Region: EamA; pfam00892 911045013247 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045013248 EamA-like transporter family; Region: EamA; pfam00892 911045013249 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 911045013250 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 911045013251 oligomer interface [polypeptide binding]; other site 911045013252 active site 911045013253 metal binding site [ion binding]; metal-binding site 911045013254 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 911045013255 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 911045013256 ligand binding site [chemical binding]; other site 911045013257 NAD binding site [chemical binding]; other site 911045013258 dimerization interface [polypeptide binding]; other site 911045013259 catalytic site [active] 911045013260 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 911045013261 putative L-serine binding site [chemical binding]; other site 911045013262 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 911045013263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045013264 catalytic residue [active] 911045013265 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 911045013266 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 911045013267 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 911045013268 active site 911045013269 substrate binding site [chemical binding]; other site 911045013270 metal binding site [ion binding]; metal-binding site 911045013271 FtsH Extracellular; Region: FtsH_ext; pfam06480 911045013272 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 911045013273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045013274 Walker A motif; other site 911045013275 ATP binding site [chemical binding]; other site 911045013276 Walker B motif; other site 911045013277 arginine finger; other site 911045013278 Peptidase family M41; Region: Peptidase_M41; pfam01434 911045013279 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 911045013280 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 911045013281 Ligand Binding Site [chemical binding]; other site 911045013282 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 911045013283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 911045013284 TPR motif; other site 911045013285 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 911045013286 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045013287 ligand binding site [chemical binding]; other site 911045013288 translocation protein TolB; Provisional; Region: tolB; PRK05137 911045013289 TolB amino-terminal domain; Region: TolB_N; pfam04052 911045013290 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 911045013291 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 911045013292 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 911045013293 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 911045013294 TolR protein; Region: tolR; TIGR02801 911045013295 TolQ protein; Region: tolQ; TIGR02796 911045013296 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045013297 active site 911045013298 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 911045013299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045013300 Walker A motif; other site 911045013301 ATP binding site [chemical binding]; other site 911045013302 Walker B motif; other site 911045013303 arginine finger; other site 911045013304 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 911045013305 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 911045013306 RuvA N terminal domain; Region: RuvA_N; pfam01330 911045013307 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 911045013308 active site 911045013309 putative DNA-binding cleft [nucleotide binding]; other site 911045013310 dimer interface [polypeptide binding]; other site 911045013311 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045013312 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045013313 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045013314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045013315 putative DNA binding site [nucleotide binding]; other site 911045013316 putative Zn2+ binding site [ion binding]; other site 911045013317 AsnC family; Region: AsnC_trans_reg; pfam01037 911045013318 hypothetical protein; Validated; Region: PRK00110 911045013319 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 911045013320 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045013321 putative active site [active] 911045013322 metal binding site [ion binding]; metal-binding site 911045013323 homodimer binding site [polypeptide binding]; other site 911045013324 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 911045013325 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 911045013326 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 911045013327 nucleotide binding site/active site [active] 911045013328 HIT family signature motif; other site 911045013329 catalytic residue [active] 911045013330 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 911045013331 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 911045013332 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 911045013333 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 911045013334 TPP-binding site [chemical binding]; other site 911045013335 dimer interface [polypeptide binding]; other site 911045013336 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 911045013337 PYR/PP interface [polypeptide binding]; other site 911045013338 dimer interface [polypeptide binding]; other site 911045013339 TPP binding site [chemical binding]; other site 911045013340 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 911045013341 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 911045013342 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 911045013343 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 911045013344 Phosphoglycerate kinase; Region: PGK; pfam00162 911045013345 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 911045013346 substrate binding site [chemical binding]; other site 911045013347 hinge regions; other site 911045013348 ADP binding site [chemical binding]; other site 911045013349 catalytic site [active] 911045013350 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 911045013351 thiamine phosphate binding site [chemical binding]; other site 911045013352 active site 911045013353 pyrophosphate binding site [ion binding]; other site 911045013354 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 911045013355 Sel1-like repeats; Region: SEL1; smart00671 911045013356 Sel1-like repeats; Region: SEL1; smart00671 911045013357 elongation factor P; Validated; Region: PRK00529 911045013358 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 911045013359 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 911045013360 RNA binding site [nucleotide binding]; other site 911045013361 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 911045013362 RNA binding site [nucleotide binding]; other site 911045013363 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 911045013364 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 911045013365 active site 911045013366 dimerization interface [polypeptide binding]; other site 911045013367 Uncharacterized conserved protein [Function unknown]; Region: COG1359 911045013368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045013369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045013370 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 911045013371 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045013372 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 911045013373 active site 911045013374 metal binding site [ion binding]; metal-binding site 911045013375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 911045013376 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 911045013377 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 911045013378 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045013379 P-loop; other site 911045013380 Magnesium ion binding site [ion binding]; other site 911045013381 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045013382 Magnesium ion binding site [ion binding]; other site 911045013383 hypothetical protein; Validated; Region: PRK09039 911045013384 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045013385 ligand binding site [chemical binding]; other site 911045013386 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 911045013387 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 911045013388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 911045013389 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 911045013390 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 911045013391 NAD(P) binding site [chemical binding]; other site 911045013392 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 911045013393 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 911045013394 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 911045013395 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 911045013396 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045013397 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 911045013398 Walker A/P-loop; other site 911045013399 ATP binding site [chemical binding]; other site 911045013400 Q-loop/lid; other site 911045013401 ABC transporter signature motif; other site 911045013402 Walker B; other site 911045013403 D-loop; other site 911045013404 H-loop/switch region; other site 911045013405 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 911045013406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013407 NAD(P) binding site [chemical binding]; other site 911045013408 active site 911045013409 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 911045013410 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 911045013411 acyl-activating enzyme (AAE) consensus motif; other site 911045013412 putative AMP binding site [chemical binding]; other site 911045013413 putative active site [active] 911045013414 putative CoA binding site [chemical binding]; other site 911045013415 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045013416 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 911045013417 acyl-CoA synthetase; Validated; Region: PRK08162 911045013418 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 911045013419 acyl-activating enzyme (AAE) consensus motif; other site 911045013420 putative active site [active] 911045013421 AMP binding site [chemical binding]; other site 911045013422 putative CoA binding site [chemical binding]; other site 911045013423 Uncharacterized small protein [Function unknown]; Region: COG5570 911045013424 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 911045013425 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 911045013426 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 911045013427 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 911045013428 ATP-grasp domain; Region: ATP-grasp; pfam02222 911045013429 multidrug efflux protein; Reviewed; Region: PRK01766 911045013430 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 911045013431 cation binding site [ion binding]; other site 911045013432 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 911045013433 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 911045013434 putative dimer interface [polypeptide binding]; other site 911045013435 putative active site [active] 911045013436 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 911045013437 TPR repeat; Region: TPR_11; pfam13414 911045013438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045013439 binding surface 911045013440 TPR motif; other site 911045013441 TPR repeat; Region: TPR_11; pfam13414 911045013442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045013443 binding surface 911045013444 TPR motif; other site 911045013445 TPR repeat; Region: TPR_11; pfam13414 911045013446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045013447 binding surface 911045013448 Tetratricopeptide repeat; Region: TPR_16; pfam13432 911045013449 TPR motif; other site 911045013450 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 911045013451 acetoacetate decarboxylase; Provisional; Region: PRK02265 911045013452 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 911045013453 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 911045013454 ABC1 family; Region: ABC1; cl17513 911045013455 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 911045013456 active site 911045013457 ATP binding site [chemical binding]; other site 911045013458 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 911045013459 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045013460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045013461 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 911045013462 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 911045013463 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045013464 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 911045013465 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 911045013466 active site 911045013467 metal binding site [ion binding]; metal-binding site 911045013468 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045013469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045013470 active site 911045013471 adenylosuccinate lyase; Provisional; Region: PRK07492 911045013472 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 911045013473 tetramer interface [polypeptide binding]; other site 911045013474 active site 911045013475 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 911045013476 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045013477 active site 911045013478 metal binding site [ion binding]; metal-binding site 911045013479 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045013480 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045013481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045013482 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 911045013483 CoenzymeA binding site [chemical binding]; other site 911045013484 subunit interaction site [polypeptide binding]; other site 911045013485 PHB binding site; other site 911045013486 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 911045013487 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 911045013488 active site 911045013489 Zn binding site [ion binding]; other site 911045013490 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 911045013491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045013492 active site 911045013493 phosphorylation site [posttranslational modification] 911045013494 intermolecular recognition site; other site 911045013495 dimerization interface [polypeptide binding]; other site 911045013496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045013497 Walker A motif; other site 911045013498 ATP binding site [chemical binding]; other site 911045013499 Walker B motif; other site 911045013500 arginine finger; other site 911045013501 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 911045013502 DNA-binding interface [nucleotide binding]; DNA binding site 911045013503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 911045013504 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 911045013505 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 911045013506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 911045013507 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 911045013508 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 911045013509 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 911045013510 pyruvate kinase; Provisional; Region: PRK06247 911045013511 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 911045013512 domain interfaces; other site 911045013513 active site 911045013514 short chain dehydrogenase; Provisional; Region: PRK06197 911045013515 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 911045013516 putative NAD(P) binding site [chemical binding]; other site 911045013517 active site 911045013518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045013519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045013520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 911045013521 TPR repeat; Region: TPR_11; pfam13414 911045013522 binding surface 911045013523 TPR motif; other site 911045013524 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 911045013525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045013526 Response regulator receiver domain; Region: Response_reg; pfam00072 911045013527 active site 911045013528 phosphorylation site [posttranslational modification] 911045013529 intermolecular recognition site; other site 911045013530 dimerization interface [polypeptide binding]; other site 911045013531 N-formylglutamate amidohydrolase; Region: FGase; cl01522 911045013532 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 911045013533 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 911045013534 trimer interface [polypeptide binding]; other site 911045013535 active site 911045013536 substrate binding site [chemical binding]; other site 911045013537 CoA binding site [chemical binding]; other site 911045013538 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 911045013539 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 911045013540 active site 911045013541 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 911045013542 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 911045013543 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 911045013544 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 911045013545 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 911045013546 putative dimer interface [polypeptide binding]; other site 911045013547 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 911045013548 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 911045013549 tetramer interface [polypeptide binding]; other site 911045013550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045013551 catalytic residue [active] 911045013552 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045013553 putative catalytic site [active] 911045013554 putative metal binding site [ion binding]; other site 911045013555 putative phosphate binding site [ion binding]; other site 911045013556 Predicted membrane protein [Function unknown]; Region: COG2259 911045013557 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 911045013558 hypothetical protein; Provisional; Region: PRK05409 911045013559 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 911045013560 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 911045013561 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 911045013562 active site 911045013563 dimer interface [polypeptide binding]; other site 911045013564 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 911045013565 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 911045013566 active site 911045013567 FMN binding site [chemical binding]; other site 911045013568 substrate binding site [chemical binding]; other site 911045013569 3Fe-4S cluster binding site [ion binding]; other site 911045013570 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 911045013571 domain interface; other site 911045013572 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 911045013573 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045013574 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045013575 dimer interface [polypeptide binding]; other site 911045013576 putative CheW interface [polypeptide binding]; other site 911045013577 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 911045013578 active site 911045013579 catalytic triad [active] 911045013580 oxyanion hole [active] 911045013581 Transglycosylase SLT domain; Region: SLT_2; pfam13406 911045013582 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 911045013583 N-acetyl-D-glucosamine binding site [chemical binding]; other site 911045013584 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 911045013585 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 911045013586 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 911045013587 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 911045013588 putative active site [active] 911045013589 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 911045013590 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 911045013591 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 911045013592 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 911045013593 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 911045013594 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 911045013595 ligand binding site [chemical binding]; other site 911045013596 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 911045013597 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 911045013598 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 911045013599 ferrochelatase; Reviewed; Region: hemH; PRK00035 911045013600 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 911045013601 active site 911045013602 C-terminal domain interface [polypeptide binding]; other site 911045013603 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 911045013604 active site 911045013605 N-terminal domain interface [polypeptide binding]; other site 911045013606 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 911045013607 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 911045013608 acyl-activating enzyme (AAE) consensus motif; other site 911045013609 active site 911045013610 AMP binding site [chemical binding]; other site 911045013611 CoA binding site [chemical binding]; other site 911045013612 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 911045013613 B1 nucleotide binding pocket [chemical binding]; other site 911045013614 B2 nucleotide binding pocket [chemical binding]; other site 911045013615 CAS motifs; other site 911045013616 active site 911045013617 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 911045013618 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 911045013619 Walker A/P-loop; other site 911045013620 ATP binding site [chemical binding]; other site 911045013621 Q-loop/lid; other site 911045013622 ABC transporter signature motif; other site 911045013623 Walker B; other site 911045013624 D-loop; other site 911045013625 H-loop/switch region; other site 911045013626 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 911045013627 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 911045013628 putative ligand binding site [chemical binding]; other site 911045013629 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 911045013630 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 911045013631 TM-ABC transporter signature motif; other site 911045013632 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 911045013633 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045013634 TM-ABC transporter signature motif; other site 911045013635 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 911045013636 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 911045013637 Walker A/P-loop; other site 911045013638 ATP binding site [chemical binding]; other site 911045013639 Q-loop/lid; other site 911045013640 ABC transporter signature motif; other site 911045013641 Walker B; other site 911045013642 D-loop; other site 911045013643 H-loop/switch region; other site 911045013644 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 911045013645 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 911045013646 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 911045013647 acyl-activating enzyme (AAE) consensus motif; other site 911045013648 putative AMP binding site [chemical binding]; other site 911045013649 putative active site [active] 911045013650 putative CoA binding site [chemical binding]; other site 911045013651 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045013652 DctM-like transporters; Region: DctM; pfam06808 911045013653 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045013654 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045013655 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 911045013656 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045013657 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 911045013658 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 911045013659 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 911045013660 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 911045013661 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 911045013662 NAD binding site [chemical binding]; other site 911045013663 Phe binding site; other site 911045013664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045013665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045013666 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 911045013667 putative effector binding pocket; other site 911045013668 dimerization interface [polypeptide binding]; other site 911045013669 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 911045013670 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 911045013671 structural tetrad; other site 911045013672 FOG: WD40 repeat [General function prediction only]; Region: COG2319 911045013673 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 911045013674 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 911045013675 P-loop, Walker A motif; other site 911045013676 Base recognition motif; other site 911045013677 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 911045013678 aspartate aminotransferase; Provisional; Region: PRK05764 911045013679 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045013680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045013681 homodimer interface [polypeptide binding]; other site 911045013682 catalytic residue [active] 911045013683 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045013684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045013685 DNA binding site [nucleotide binding] 911045013686 domain linker motif; other site 911045013687 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045013688 DinB family; Region: DinB; cl17821 911045013689 DinB superfamily; Region: DinB_2; pfam12867 911045013690 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045013691 MarR family; Region: MarR_2; pfam12802 911045013692 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 911045013693 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 911045013694 Walker A/P-loop; other site 911045013695 ATP binding site [chemical binding]; other site 911045013696 Q-loop/lid; other site 911045013697 ABC transporter signature motif; other site 911045013698 Walker B; other site 911045013699 D-loop; other site 911045013700 H-loop/switch region; other site 911045013701 Creatinine amidohydrolase; Region: Creatininase; pfam02633 911045013702 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 911045013703 B12 binding site [chemical binding]; other site 911045013704 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 911045013705 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045013706 FeS/SAM binding site; other site 911045013707 ArsC family; Region: ArsC; pfam03960 911045013708 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 911045013709 putative catalytic residues [active] 911045013710 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045013711 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 911045013712 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045013713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013714 putative PBP binding loops; other site 911045013715 dimer interface [polypeptide binding]; other site 911045013716 ABC-ATPase subunit interface; other site 911045013717 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 911045013718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013719 dimer interface [polypeptide binding]; other site 911045013720 conserved gate region; other site 911045013721 ABC-ATPase subunit interface; other site 911045013722 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 911045013723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045013724 Walker A/P-loop; other site 911045013725 ATP binding site [chemical binding]; other site 911045013726 Q-loop/lid; other site 911045013727 ABC transporter signature motif; other site 911045013728 Walker B; other site 911045013729 D-loop; other site 911045013730 H-loop/switch region; other site 911045013731 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 911045013732 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045013733 Walker A/P-loop; other site 911045013734 ATP binding site [chemical binding]; other site 911045013735 Q-loop/lid; other site 911045013736 ABC transporter signature motif; other site 911045013737 Walker B; other site 911045013738 D-loop; other site 911045013739 H-loop/switch region; other site 911045013740 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045013741 Uncharacterized conserved protein [Function unknown]; Region: COG4278 911045013742 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 911045013743 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045013744 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045013745 catalytic residue [active] 911045013746 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045013747 putative catalytic site [active] 911045013748 putative metal binding site [ion binding]; other site 911045013749 putative phosphate binding site [ion binding]; other site 911045013750 Methyltransferase domain; Region: Methyltransf_23; pfam13489 911045013751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045013752 S-adenosylmethionine binding site [chemical binding]; other site 911045013753 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045013754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045013755 LysR substrate binding domain; Region: LysR_substrate; pfam03466 911045013756 dimerization interface [polypeptide binding]; other site 911045013757 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 911045013758 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 911045013759 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 911045013760 catalytic residue [active] 911045013761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045013762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045013763 dimerization interface [polypeptide binding]; other site 911045013764 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 911045013765 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 911045013766 metal-binding site [ion binding] 911045013767 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 911045013768 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 911045013769 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045013770 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 911045013771 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 911045013772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045013773 DNA-binding site [nucleotide binding]; DNA binding site 911045013774 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 911045013775 Uncharacterized conserved protein [Function unknown]; Region: COG3025 911045013776 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 911045013777 putative active site [active] 911045013778 putative metal binding residues [ion binding]; other site 911045013779 signature motif; other site 911045013780 putative triphosphate binding site [ion binding]; other site 911045013781 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 911045013782 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 911045013783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045013784 DNA-binding site [nucleotide binding]; DNA binding site 911045013785 UTRA domain; Region: UTRA; pfam07702 911045013786 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 911045013787 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 911045013788 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 911045013789 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 911045013790 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 911045013791 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045013792 Walker A/P-loop; other site 911045013793 ATP binding site [chemical binding]; other site 911045013794 Q-loop/lid; other site 911045013795 ABC transporter signature motif; other site 911045013796 Walker B; other site 911045013797 D-loop; other site 911045013798 H-loop/switch region; other site 911045013799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045013800 Walker A/P-loop; other site 911045013801 ATP binding site [chemical binding]; other site 911045013802 ABC transporter; Region: ABC_tran; pfam00005 911045013803 Q-loop/lid; other site 911045013804 ABC transporter signature motif; other site 911045013805 Walker B; other site 911045013806 D-loop; other site 911045013807 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 911045013808 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 911045013809 trimer interface [polypeptide binding]; other site 911045013810 active site 911045013811 substrate binding site [chemical binding]; other site 911045013812 CoA binding site [chemical binding]; other site 911045013813 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 911045013814 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 911045013815 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 911045013816 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 911045013817 active site 911045013818 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 911045013819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045013820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045013821 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 911045013822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045013823 catalytic loop [active] 911045013824 iron binding site [ion binding]; other site 911045013825 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 911045013826 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 911045013827 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 911045013828 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 911045013829 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 911045013830 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 911045013831 tellurium resistance terB-like protein; Region: terB_like; cl11965 911045013832 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 911045013833 metal binding site [ion binding]; metal-binding site 911045013834 putative metal binding site [ion binding]; other site 911045013835 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 911045013836 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 911045013837 catalytic triad [active] 911045013838 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 911045013839 pyruvate carboxylase; Reviewed; Region: PRK12999 911045013840 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045013841 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 911045013842 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 911045013843 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 911045013844 active site 911045013845 catalytic residues [active] 911045013846 metal binding site [ion binding]; metal-binding site 911045013847 homodimer binding site [polypeptide binding]; other site 911045013848 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 911045013849 carboxyltransferase (CT) interaction site; other site 911045013850 biotinylation site [posttranslational modification]; other site 911045013851 Autoinducer binding domain; Region: Autoind_bind; pfam03472 911045013852 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045013853 DNA binding residues [nucleotide binding] 911045013854 dimerization interface [polypeptide binding]; other site 911045013855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 911045013856 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 911045013857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045013858 nucleotide binding region [chemical binding]; other site 911045013859 ATP-binding site [chemical binding]; other site 911045013860 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 911045013861 RNA binding surface [nucleotide binding]; other site 911045013862 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 911045013863 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 911045013864 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 911045013865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045013866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045013867 DNA binding residues [nucleotide binding] 911045013868 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 911045013869 Peptidase family M48; Region: Peptidase_M48; pfam01435 911045013870 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 911045013871 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 911045013872 Ca2+ binding site [ion binding]; other site 911045013873 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 911045013874 Ca2+ binding site [ion binding]; other site 911045013875 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 911045013876 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 911045013877 phosphate binding site [ion binding]; other site 911045013878 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045013879 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045013880 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 911045013881 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 911045013882 dimerization interface [polypeptide binding]; other site 911045013883 putative active cleft [active] 911045013884 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 911045013885 HemY protein N-terminus; Region: HemY_N; pfam07219 911045013886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 911045013887 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 911045013888 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 911045013889 active site 911045013890 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 911045013891 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 911045013892 domain interfaces; other site 911045013893 active site 911045013894 UGMP family protein; Validated; Region: PRK09604 911045013895 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 911045013896 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 911045013897 nudix motif; other site 911045013898 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 911045013899 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 911045013900 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 911045013901 YciI-like protein; Reviewed; Region: PRK12863 911045013902 EVE domain; Region: EVE; cl00728 911045013903 Predicted methyltransferase [General function prediction only]; Region: COG3897 911045013904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045013905 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045013906 DNA binding residues [nucleotide binding] 911045013907 dimerization interface [polypeptide binding]; other site 911045013908 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 911045013909 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 911045013910 metal binding site [ion binding]; metal-binding site 911045013911 putative dimer interface [polypeptide binding]; other site 911045013912 hypothetical protein; Provisional; Region: PRK06815 911045013913 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045013914 tetramer interface [polypeptide binding]; other site 911045013915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045013916 catalytic residue [active] 911045013917 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 911045013918 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 911045013919 Walker A/P-loop; other site 911045013920 ATP binding site [chemical binding]; other site 911045013921 Q-loop/lid; other site 911045013922 ABC transporter signature motif; other site 911045013923 Walker B; other site 911045013924 D-loop; other site 911045013925 H-loop/switch region; other site 911045013926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045013927 dimer interface [polypeptide binding]; other site 911045013928 conserved gate region; other site 911045013929 putative PBP binding loops; other site 911045013930 ABC-ATPase subunit interface; other site 911045013931 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 911045013932 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 911045013933 substrate binding pocket [chemical binding]; other site 911045013934 membrane-bound complex binding site; other site 911045013935 hinge residues; other site 911045013936 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 911045013937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045013938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045013939 Coenzyme A binding pocket [chemical binding]; other site 911045013940 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 911045013941 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 911045013942 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 911045013943 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 911045013944 putative acetyltransferase; Provisional; Region: PRK03624 911045013945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045013946 Coenzyme A binding pocket [chemical binding]; other site 911045013947 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 911045013948 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 911045013949 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 911045013950 active site 911045013951 tartrate dehydrogenase; Region: TTC; TIGR02089 911045013952 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 911045013953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045013954 NAD(P) binding site [chemical binding]; other site 911045013955 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045013956 active site 911045013957 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 911045013958 dimer interface [polypeptide binding]; other site 911045013959 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045013960 active site 911045013961 metal binding site [ion binding]; metal-binding site 911045013962 glutathione binding site [chemical binding]; other site 911045013963 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045013964 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 911045013965 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 911045013966 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045013967 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 911045013968 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 911045013969 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 911045013970 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 911045013971 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 911045013972 active site clefts [active] 911045013973 zinc binding site [ion binding]; other site 911045013974 dimer interface [polypeptide binding]; other site 911045013975 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 911045013976 homotrimer interaction site [polypeptide binding]; other site 911045013977 putative active site [active] 911045013978 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 911045013979 putative active site [active] 911045013980 putative catalytic site [active] 911045013981 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 911045013982 putative active site [active] 911045013983 putative catalytic site [active] 911045013984 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045013985 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045013986 dimer interface [polypeptide binding]; other site 911045013987 putative CheW interface [polypeptide binding]; other site 911045013988 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 911045013989 putative protease; Provisional; Region: PRK15452 911045013990 Peptidase family U32; Region: Peptidase_U32; pfam01136 911045013991 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 911045013992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045013993 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045013994 dimerization interface [polypeptide binding]; other site 911045013995 Helix-turn-helix domain; Region: HTH_17; pfam12728 911045013996 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 911045013997 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 911045013998 Citrate synthase; Region: Citrate_synt; pfam00285 911045013999 dimer interface [polypeptide binding]; other site 911045014000 active site 911045014001 oxalacetate/citrate binding site [chemical binding]; other site 911045014002 citrylCoA binding site [chemical binding]; other site 911045014003 coenzyme A binding site [chemical binding]; other site 911045014004 catalytic triad [active] 911045014005 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045014006 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 911045014007 DctM-like transporters; Region: DctM; pfam06808 911045014008 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045014009 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 911045014010 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045014011 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 911045014012 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 911045014013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045014014 active site 911045014015 phosphorylation site [posttranslational modification] 911045014016 intermolecular recognition site; other site 911045014017 dimerization interface [polypeptide binding]; other site 911045014018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 911045014019 Walker A motif; other site 911045014020 ATP binding site [chemical binding]; other site 911045014021 Walker B motif; other site 911045014022 arginine finger; other site 911045014023 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 911045014024 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 911045014025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045014026 dimer interface [polypeptide binding]; other site 911045014027 phosphorylation site [posttranslational modification] 911045014028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045014029 ATP binding site [chemical binding]; other site 911045014030 Mg2+ binding site [ion binding]; other site 911045014031 G-X-G motif; other site 911045014032 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 911045014033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 911045014034 Walker A/P-loop; other site 911045014035 ATP binding site [chemical binding]; other site 911045014036 Q-loop/lid; other site 911045014037 ABC transporter signature motif; other site 911045014038 Walker B; other site 911045014039 D-loop; other site 911045014040 H-loop/switch region; other site 911045014041 TOBE domain; Region: TOBE; pfam03459 911045014042 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 911045014043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014044 dimer interface [polypeptide binding]; other site 911045014045 conserved gate region; other site 911045014046 putative PBP binding loops; other site 911045014047 ABC-ATPase subunit interface; other site 911045014048 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 911045014049 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 911045014050 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 911045014051 putative hydrophobic ligand binding site [chemical binding]; other site 911045014052 protein interface [polypeptide binding]; other site 911045014053 gate; other site 911045014054 Predicted transcriptional regulator [Transcription]; Region: COG2378 911045014055 HTH domain; Region: HTH_11; pfam08279 911045014056 WYL domain; Region: WYL; pfam13280 911045014057 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045014058 dimerization interface [polypeptide binding]; other site 911045014059 putative DNA binding site [nucleotide binding]; other site 911045014060 putative Zn2+ binding site [ion binding]; other site 911045014061 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 911045014062 putative hydrophobic ligand binding site [chemical binding]; other site 911045014063 Uncharacterized conserved protein [Function unknown]; Region: COG3791 911045014064 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 911045014065 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045014066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045014067 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045014068 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045014069 choline dehydrogenase; Validated; Region: PRK02106 911045014070 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 911045014071 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 911045014072 Protein of unknown function (DUF533); Region: DUF533; pfam04391 911045014073 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 911045014074 putative metal binding site [ion binding]; other site 911045014075 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045014076 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 911045014077 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 911045014078 AsnC family; Region: AsnC_trans_reg; pfam01037 911045014079 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 911045014080 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 911045014081 dimer interface [polypeptide binding]; other site 911045014082 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 911045014083 active site 911045014084 Fe binding site [ion binding]; other site 911045014085 FG-GAP repeat; Region: FG-GAP_2; pfam14312 911045014086 FG-GAP repeat; Region: FG-GAP_2; pfam14312 911045014087 FG-GAP repeat; Region: FG-GAP_2; pfam14312 911045014088 topology modulation protein; Reviewed; Region: PRK08118 911045014089 AAA domain; Region: AAA_17; pfam13207 911045014090 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045014091 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045014092 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045014093 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 911045014094 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 911045014095 transmembrane helices; other site 911045014096 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 911045014097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045014098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045014099 putative substrate translocation pore; other site 911045014100 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 911045014101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 911045014102 BioY family; Region: BioY; pfam02632 911045014103 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 911045014104 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 911045014105 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 911045014106 Walker A/P-loop; other site 911045014107 ATP binding site [chemical binding]; other site 911045014108 Q-loop/lid; other site 911045014109 ABC transporter signature motif; other site 911045014110 Walker B; other site 911045014111 D-loop; other site 911045014112 H-loop/switch region; other site 911045014113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 911045014114 Helix-turn-helix domain; Region: HTH_18; pfam12833 911045014115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045014116 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 911045014117 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 911045014118 Autotransporter beta-domain; Region: Autotransporter; smart00869 911045014119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045014120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045014121 enoyl-CoA hydratase; Provisional; Region: PRK12478 911045014122 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045014123 substrate binding site [chemical binding]; other site 911045014124 oxyanion hole (OAH) forming residues; other site 911045014125 trimer interface [polypeptide binding]; other site 911045014126 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 911045014127 Beta-lactamase; Region: Beta-lactamase; pfam00144 911045014128 reductive dehalogenase; Region: RDH; TIGR02486 911045014129 reductive dehalogenase; Region: RDH; TIGR02486 911045014130 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 911045014131 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 911045014132 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 911045014133 FMN-binding pocket [chemical binding]; other site 911045014134 flavin binding motif; other site 911045014135 phosphate binding motif [ion binding]; other site 911045014136 beta-alpha-beta structure motif; other site 911045014137 NAD binding pocket [chemical binding]; other site 911045014138 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045014139 catalytic loop [active] 911045014140 iron binding site [ion binding]; other site 911045014141 AAA domain; Region: AAA_17; cl17253 911045014142 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045014143 DNA binding residues [nucleotide binding] 911045014144 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045014145 dimerization interface [polypeptide binding]; other site 911045014146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045014147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045014148 DNA binding residues [nucleotide binding] 911045014149 dimerization interface [polypeptide binding]; other site 911045014150 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045014151 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045014152 DNA binding residues [nucleotide binding] 911045014153 dimerization interface [polypeptide binding]; other site 911045014154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045014155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045014156 dimer interface [polypeptide binding]; other site 911045014157 phosphorylation site [posttranslational modification] 911045014158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045014159 ATP binding site [chemical binding]; other site 911045014160 Mg2+ binding site [ion binding]; other site 911045014161 G-X-G motif; other site 911045014162 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045014163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045014164 active site 911045014165 phosphorylation site [posttranslational modification] 911045014166 intermolecular recognition site; other site 911045014167 dimerization interface [polypeptide binding]; other site 911045014168 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045014169 DNA binding site [nucleotide binding] 911045014170 OsmC-like protein; Region: OsmC; pfam02566 911045014171 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 911045014172 Prostaglandin dehydrogenases; Region: PGDH; cd05288 911045014173 NAD(P) binding site [chemical binding]; other site 911045014174 substrate binding site [chemical binding]; other site 911045014175 dimer interface [polypeptide binding]; other site 911045014176 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 911045014177 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045014178 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045014179 putative DNA binding site [nucleotide binding]; other site 911045014180 putative Zn2+ binding site [ion binding]; other site 911045014181 AsnC family; Region: AsnC_trans_reg; pfam01037 911045014182 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 911045014183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045014184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045014185 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 911045014186 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 911045014187 isovaleryl-CoA dehydrogenase; Region: PLN02519 911045014188 substrate binding site [chemical binding]; other site 911045014189 FAD binding site [chemical binding]; other site 911045014190 catalytic base [active] 911045014191 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 911045014192 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 911045014193 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 911045014194 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 911045014195 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 911045014196 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 911045014197 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 911045014198 carboxyltransferase (CT) interaction site; other site 911045014199 biotinylation site [posttranslational modification]; other site 911045014200 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 911045014201 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 911045014202 active site 911045014203 acyl-activating enzyme (AAE) consensus motif; other site 911045014204 putative CoA binding site [chemical binding]; other site 911045014205 AMP binding site [chemical binding]; other site 911045014206 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 911045014207 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 911045014208 active site 911045014209 catalytic residues [active] 911045014210 metal binding site [ion binding]; metal-binding site 911045014211 enoyl-CoA hydratase; Provisional; Region: PRK07468 911045014212 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045014213 substrate binding site [chemical binding]; other site 911045014214 oxyanion hole (OAH) forming residues; other site 911045014215 trimer interface [polypeptide binding]; other site 911045014216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045014217 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045014218 putative substrate translocation pore; other site 911045014219 Isochorismatase family; Region: Isochorismatase; pfam00857 911045014220 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 911045014221 catalytic triad [active] 911045014222 conserved cis-peptide bond; other site 911045014223 Isochorismatase family; Region: Isochorismatase; pfam00857 911045014224 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 911045014225 catalytic triad [active] 911045014226 conserved cis-peptide bond; other site 911045014227 Isochorismatase family; Region: Isochorismatase; pfam00857 911045014228 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 911045014229 catalytic triad [active] 911045014230 conserved cis-peptide bond; other site 911045014231 Isochorismatase family; Region: Isochorismatase; pfam00857 911045014232 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 911045014233 catalytic triad [active] 911045014234 conserved cis-peptide bond; other site 911045014235 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 911045014236 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 911045014237 conserved cys residue [active] 911045014238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045014239 Isochorismatase family; Region: Isochorismatase; pfam00857 911045014240 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 911045014241 catalytic triad [active] 911045014242 conserved cis-peptide bond; other site 911045014243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 911045014244 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 911045014245 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 911045014246 catalytic loop [active] 911045014247 iron binding site [ion binding]; other site 911045014248 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 911045014249 FAD binding pocket [chemical binding]; other site 911045014250 FAD binding motif [chemical binding]; other site 911045014251 phosphate binding motif [ion binding]; other site 911045014252 beta-alpha-beta structure motif; other site 911045014253 NAD binding pocket [chemical binding]; other site 911045014254 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 911045014255 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 911045014256 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 911045014257 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 911045014258 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 911045014259 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 911045014260 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 911045014261 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 911045014262 ApbE family; Region: ApbE; pfam02424 911045014263 Protein of unknown function (DUF539); Region: DUF539; cl01129 911045014264 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 911045014265 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 911045014266 ATP binding site [chemical binding]; other site 911045014267 Mg++ binding site [ion binding]; other site 911045014268 motif III; other site 911045014269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 911045014270 nucleotide binding region [chemical binding]; other site 911045014271 ATP-binding site [chemical binding]; other site 911045014272 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 911045014273 RNA binding site [nucleotide binding]; other site 911045014274 hypothetical protein; Validated; Region: PRK00124 911045014275 amidase; Provisional; Region: PRK07056 911045014276 Amidase; Region: Amidase; cl11426 911045014277 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 911045014278 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 911045014279 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 911045014280 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 911045014281 RNA binding site [nucleotide binding]; other site 911045014282 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045014283 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 911045014284 EamA-like transporter family; Region: EamA; pfam00892 911045014285 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 911045014286 EamA-like transporter family; Region: EamA; pfam00892 911045014287 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045014288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045014289 dimerization interface [polypeptide binding]; other site 911045014290 putative DNA binding site [nucleotide binding]; other site 911045014291 putative Zn2+ binding site [ion binding]; other site 911045014292 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045014293 active site 911045014294 AAA domain; Region: AAA_30; pfam13604 911045014295 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 911045014296 Family description; Region: UvrD_C_2; pfam13538 911045014297 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 911045014298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045014299 catalytic residue [active] 911045014300 Phosphotransferase enzyme family; Region: APH; pfam01636 911045014301 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 911045014302 active site 911045014303 ATP binding site [chemical binding]; other site 911045014304 substrate binding site [chemical binding]; other site 911045014305 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 911045014306 homodimer interface [polypeptide binding]; other site 911045014307 homotetramer interface [polypeptide binding]; other site 911045014308 active site pocket [active] 911045014309 cleavage site 911045014310 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045014311 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045014312 substrate binding site [chemical binding]; other site 911045014313 ATP binding site [chemical binding]; other site 911045014314 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045014315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014316 DNA-binding site [nucleotide binding]; DNA binding site 911045014317 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 911045014318 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 911045014319 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 911045014320 putative ligand binding site [chemical binding]; other site 911045014321 NAD binding site [chemical binding]; other site 911045014322 catalytic site [active] 911045014323 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045014324 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045014325 domain linker motif; other site 911045014326 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 911045014327 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045014328 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 911045014329 active site 911045014330 catalytic tetrad [active] 911045014331 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 911045014332 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 911045014333 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 911045014334 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 911045014335 molybdopterin cofactor binding site; other site 911045014336 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 911045014337 molybdopterin cofactor binding site; other site 911045014338 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 911045014339 iron-sulfur cluster [ion binding]; other site 911045014340 [2Fe-2S] cluster binding site [ion binding]; other site 911045014341 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 911045014342 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 911045014343 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 911045014344 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 911045014345 ligand binding site [chemical binding]; other site 911045014346 flexible hinge region; other site 911045014347 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 911045014348 putative switch regulator; other site 911045014349 non-specific DNA interactions [nucleotide binding]; other site 911045014350 DNA binding site [nucleotide binding] 911045014351 sequence specific DNA binding site [nucleotide binding]; other site 911045014352 putative cAMP binding site [chemical binding]; other site 911045014353 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 911045014354 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 911045014355 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 911045014356 Predicted transcriptional regulator [Transcription]; Region: COG2378 911045014357 HTH domain; Region: HTH_11; pfam08279 911045014358 WYL domain; Region: WYL; pfam13280 911045014359 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 911045014360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045014361 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 911045014362 Predicted transcriptional regulators [Transcription]; Region: COG1733 911045014363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045014364 dimerization interface [polypeptide binding]; other site 911045014365 putative DNA binding site [nucleotide binding]; other site 911045014366 putative Zn2+ binding site [ion binding]; other site 911045014367 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 911045014368 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045014369 substrate binding site [chemical binding]; other site 911045014370 oxyanion hole (OAH) forming residues; other site 911045014371 trimer interface [polypeptide binding]; other site 911045014372 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 911045014373 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045014374 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045014375 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045014376 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 911045014377 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045014378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014379 dimer interface [polypeptide binding]; other site 911045014380 conserved gate region; other site 911045014381 putative PBP binding loops; other site 911045014382 ABC-ATPase subunit interface; other site 911045014383 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 911045014384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014385 dimer interface [polypeptide binding]; other site 911045014386 conserved gate region; other site 911045014387 putative PBP binding loops; other site 911045014388 ABC-ATPase subunit interface; other site 911045014389 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 911045014390 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 911045014391 Walker A/P-loop; other site 911045014392 ATP binding site [chemical binding]; other site 911045014393 Q-loop/lid; other site 911045014394 ABC transporter signature motif; other site 911045014395 Walker B; other site 911045014396 D-loop; other site 911045014397 H-loop/switch region; other site 911045014398 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 911045014399 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 911045014400 Walker A/P-loop; other site 911045014401 ATP binding site [chemical binding]; other site 911045014402 Q-loop/lid; other site 911045014403 ABC transporter signature motif; other site 911045014404 Walker B; other site 911045014405 D-loop; other site 911045014406 H-loop/switch region; other site 911045014407 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 911045014408 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 911045014409 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 911045014410 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 911045014411 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 911045014412 DNA binding site [nucleotide binding] 911045014413 active site 911045014414 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 911045014415 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 911045014416 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 911045014417 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 911045014418 NAD binding site [chemical binding]; other site 911045014419 homotetramer interface [polypeptide binding]; other site 911045014420 homodimer interface [polypeptide binding]; other site 911045014421 active site 911045014422 Transcriptional regulator [Transcription]; Region: IclR; COG1414 911045014423 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 911045014424 Bacterial transcriptional regulator; Region: IclR; pfam01614 911045014425 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 911045014426 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 911045014427 active site 911045014428 catalytic tetrad [active] 911045014429 Amidohydrolase; Region: Amidohydro_2; pfam04909 911045014430 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 911045014431 galactarate dehydratase; Region: galactar-dH20; TIGR03248 911045014432 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 911045014433 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 911045014434 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 911045014435 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 911045014436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045014437 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 911045014438 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045014439 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045014440 active site 911045014441 metal binding site [ion binding]; metal-binding site 911045014442 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045014443 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 911045014444 DNA binding residues [nucleotide binding] 911045014445 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 911045014446 putative NAD(P) binding site [chemical binding]; other site 911045014447 homodimer interface [polypeptide binding]; other site 911045014448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045014449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045014450 LysR substrate binding domain; Region: LysR_substrate; pfam03466 911045014451 dimerization interface [polypeptide binding]; other site 911045014452 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 911045014453 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 911045014454 PYR/PP interface [polypeptide binding]; other site 911045014455 dimer interface [polypeptide binding]; other site 911045014456 TPP binding site [chemical binding]; other site 911045014457 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 911045014458 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 911045014459 TPP-binding site [chemical binding]; other site 911045014460 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045014461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014462 DNA-binding site [nucleotide binding]; DNA binding site 911045014463 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 911045014464 hypothetical protein; Provisional; Region: PRK07475 911045014465 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 911045014466 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 911045014467 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045014468 dimerization interface [polypeptide binding]; other site 911045014469 putative DNA binding site [nucleotide binding]; other site 911045014470 putative Zn2+ binding site [ion binding]; other site 911045014471 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 911045014472 putative hydrophobic ligand binding site [chemical binding]; other site 911045014473 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045014474 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045014475 dimer interface [polypeptide binding]; other site 911045014476 putative CheW interface [polypeptide binding]; other site 911045014477 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 911045014478 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045014479 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 911045014480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045014481 FeS/SAM binding site; other site 911045014482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 911045014483 Methyltransferase domain; Region: Methyltransf_23; pfam13489 911045014484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045014485 S-adenosylmethionine binding site [chemical binding]; other site 911045014486 SCP-2 sterol transfer family; Region: SCP2; pfam02036 911045014487 S-formylglutathione hydrolase; Region: PLN02442 911045014488 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 911045014489 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 911045014490 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 911045014491 substrate binding site [chemical binding]; other site 911045014492 catalytic Zn binding site [ion binding]; other site 911045014493 NAD binding site [chemical binding]; other site 911045014494 structural Zn binding site [ion binding]; other site 911045014495 dimer interface [polypeptide binding]; other site 911045014496 Predicted membrane protein [Function unknown]; Region: COG2855 911045014497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045014498 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045014499 putative substrate translocation pore; other site 911045014500 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045014501 dimerization interface [polypeptide binding]; other site 911045014502 putative DNA binding site [nucleotide binding]; other site 911045014503 putative Zn2+ binding site [ion binding]; other site 911045014504 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045014505 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 911045014506 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045014507 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 911045014508 active site 911045014509 metal binding site [ion binding]; metal-binding site 911045014510 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 911045014511 putative transcriptional regulator; Provisional; Region: PRK11640 911045014512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045014513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 911045014514 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 911045014515 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 911045014516 active site 1 [active] 911045014517 dimer interface [polypeptide binding]; other site 911045014518 hexamer interface [polypeptide binding]; other site 911045014519 active site 2 [active] 911045014520 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 911045014521 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 911045014522 active site pocket [active] 911045014523 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045014524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014525 DNA-binding site [nucleotide binding]; DNA binding site 911045014526 FCD domain; Region: FCD; pfam07729 911045014527 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045014528 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045014529 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 911045014530 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 911045014531 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 911045014532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045014533 non-specific DNA binding site [nucleotide binding]; other site 911045014534 salt bridge; other site 911045014535 sequence-specific DNA binding site [nucleotide binding]; other site 911045014536 Cupin domain; Region: Cupin_2; pfam07883 911045014537 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045014538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 911045014539 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 911045014540 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 911045014541 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 911045014542 NAD binding site [chemical binding]; other site 911045014543 homotetramer interface [polypeptide binding]; other site 911045014544 homodimer interface [polypeptide binding]; other site 911045014545 substrate binding site [chemical binding]; other site 911045014546 active site 911045014547 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 911045014548 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 911045014549 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 911045014550 dimer interaction site [polypeptide binding]; other site 911045014551 substrate-binding tunnel; other site 911045014552 active site 911045014553 catalytic site [active] 911045014554 substrate binding site [chemical binding]; other site 911045014555 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 911045014556 Acetokinase family; Region: Acetate_kinase; cl17229 911045014557 propionate/acetate kinase; Provisional; Region: PRK12379 911045014558 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045014559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045014560 Coenzyme A binding pocket [chemical binding]; other site 911045014561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045014562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045014563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045014564 dimerization interface [polypeptide binding]; other site 911045014565 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 911045014566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045014567 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 911045014568 DNA-binding interface [nucleotide binding]; DNA binding site 911045014569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045014570 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 911045014571 active site 911045014572 dimer interface [polypeptide binding]; other site 911045014573 catalytic nucleophile [active] 911045014574 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 911045014575 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 911045014576 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045014577 putative DNA binding site [nucleotide binding]; other site 911045014578 putative Zn2+ binding site [ion binding]; other site 911045014579 AsnC family; Region: AsnC_trans_reg; pfam01037 911045014580 polysaccharide export protein Wza; Provisional; Region: PRK15078 911045014581 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 911045014582 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045014583 homotrimer interaction site [polypeptide binding]; other site 911045014584 putative active site [active] 911045014585 pyridoxamine kinase; Validated; Region: PRK05756 911045014586 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 911045014587 pyridoxal binding site [chemical binding]; other site 911045014588 dimer interface [polypeptide binding]; other site 911045014589 ATP binding site [chemical binding]; other site 911045014590 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 911045014591 aromatic amino acid transport protein; Region: araaP; TIGR00837 911045014592 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 911045014593 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 911045014594 substrate binding site [chemical binding]; other site 911045014595 tetramer interface [polypeptide binding]; other site 911045014596 catalytic residue [active] 911045014597 Superfamily II helicase [General function prediction only]; Region: COG1204 911045014598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 911045014599 ATP binding site [chemical binding]; other site 911045014600 putative Mg++ binding site [ion binding]; other site 911045014601 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 911045014602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045014603 Major Facilitator Superfamily; Region: MFS_1; pfam07690 911045014604 putative substrate translocation pore; other site 911045014605 Salmonella virulence-associated 28kDa protein; Region: VRP3; cl04142 911045014606 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 911045014607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045014608 substrate binding site [chemical binding]; other site 911045014609 oxyanion hole (OAH) forming residues; other site 911045014610 trimer interface [polypeptide binding]; other site 911045014611 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 911045014612 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045014613 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 911045014614 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 911045014615 dimer interface [polypeptide binding]; other site 911045014616 active site 911045014617 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 911045014618 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 911045014619 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 911045014620 acyl-activating enzyme (AAE) consensus motif; other site 911045014621 putative AMP binding site [chemical binding]; other site 911045014622 putative active site [active] 911045014623 acyl-activating enzyme (AAE) consensus motif; other site 911045014624 putative CoA binding site [chemical binding]; other site 911045014625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045014626 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 911045014627 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 911045014628 putative ligand binding site [chemical binding]; other site 911045014629 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 911045014630 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 911045014631 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 911045014632 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 911045014633 putative ligand binding site [chemical binding]; other site 911045014634 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 911045014635 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 911045014636 Walker A/P-loop; other site 911045014637 ATP binding site [chemical binding]; other site 911045014638 Q-loop/lid; other site 911045014639 ABC transporter signature motif; other site 911045014640 Walker B; other site 911045014641 D-loop; other site 911045014642 H-loop/switch region; other site 911045014643 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 911045014644 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 911045014645 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 911045014646 TM-ABC transporter signature motif; other site 911045014647 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045014648 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045014649 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 911045014650 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045014651 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045014652 Walker A/P-loop; other site 911045014653 ATP binding site [chemical binding]; other site 911045014654 Q-loop/lid; other site 911045014655 ABC transporter signature motif; other site 911045014656 Walker B; other site 911045014657 D-loop; other site 911045014658 H-loop/switch region; other site 911045014659 TOBE domain; Region: TOBE_2; pfam08402 911045014660 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045014661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014662 dimer interface [polypeptide binding]; other site 911045014663 conserved gate region; other site 911045014664 putative PBP binding loops; other site 911045014665 ABC-ATPase subunit interface; other site 911045014666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014667 dimer interface [polypeptide binding]; other site 911045014668 conserved gate region; other site 911045014669 putative PBP binding loops; other site 911045014670 ABC-ATPase subunit interface; other site 911045014671 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045014672 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045014673 hypothetical protein; Provisional; Region: PRK05968 911045014674 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 911045014675 homodimer interface [polypeptide binding]; other site 911045014676 substrate-cofactor binding pocket; other site 911045014677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045014678 catalytic residue [active] 911045014679 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045014680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014681 DNA-binding site [nucleotide binding]; DNA binding site 911045014682 FCD domain; Region: FCD; pfam07729 911045014683 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045014684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045014685 DNA binding site [nucleotide binding] 911045014686 domain linker motif; other site 911045014687 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045014688 dimerization interface [polypeptide binding]; other site 911045014689 ligand binding site [chemical binding]; other site 911045014690 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045014691 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045014692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014693 dimer interface [polypeptide binding]; other site 911045014694 conserved gate region; other site 911045014695 putative PBP binding loops; other site 911045014696 ABC-ATPase subunit interface; other site 911045014697 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045014698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014699 dimer interface [polypeptide binding]; other site 911045014700 conserved gate region; other site 911045014701 putative PBP binding loops; other site 911045014702 ABC-ATPase subunit interface; other site 911045014703 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045014704 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045014705 Walker A/P-loop; other site 911045014706 ATP binding site [chemical binding]; other site 911045014707 Q-loop/lid; other site 911045014708 ABC transporter signature motif; other site 911045014709 Walker B; other site 911045014710 D-loop; other site 911045014711 H-loop/switch region; other site 911045014712 TOBE domain; Region: TOBE_2; pfam08402 911045014713 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 911045014714 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 911045014715 dimer interface [polypeptide binding]; other site 911045014716 active site 911045014717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 911045014718 substrate binding site [chemical binding]; other site 911045014719 catalytic residue [active] 911045014720 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 911045014721 TPP-binding site [chemical binding]; other site 911045014722 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 911045014723 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 911045014724 PYR/PP interface [polypeptide binding]; other site 911045014725 dimer interface [polypeptide binding]; other site 911045014726 TPP binding site [chemical binding]; other site 911045014727 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 911045014728 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 911045014729 Putative ammonia monooxygenase; Region: AmoA; pfam05145 911045014730 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 911045014731 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 911045014732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 911045014733 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045014734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045014735 active site 911045014736 phosphorylation site [posttranslational modification] 911045014737 intermolecular recognition site; other site 911045014738 dimerization interface [polypeptide binding]; other site 911045014739 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045014740 DNA binding site [nucleotide binding] 911045014741 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 911045014742 HAMP domain; Region: HAMP; pfam00672 911045014743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045014744 dimer interface [polypeptide binding]; other site 911045014745 phosphorylation site [posttranslational modification] 911045014746 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 911045014747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045014748 ATP binding site [chemical binding]; other site 911045014749 Mg2+ binding site [ion binding]; other site 911045014750 G-X-G motif; other site 911045014751 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 911045014752 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045014753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045014754 Coenzyme A binding pocket [chemical binding]; other site 911045014755 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045014756 Transcriptional regulators [Transcription]; Region: FadR; COG2186 911045014757 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014758 DNA-binding site [nucleotide binding]; DNA binding site 911045014759 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 911045014760 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045014761 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 911045014762 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 911045014763 DctM-like transporters; Region: DctM; pfam06808 911045014764 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045014765 galactarate dehydratase; Region: galactar-dH20; TIGR03248 911045014766 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 911045014767 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 911045014768 altronate oxidoreductase; Provisional; Region: PRK03643 911045014769 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 911045014770 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 911045014771 Glucuronate isomerase; Region: UxaC; pfam02614 911045014772 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 911045014773 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045014774 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045014775 substrate binding site [chemical binding]; other site 911045014776 ATP binding site [chemical binding]; other site 911045014777 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014778 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045014779 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045014780 DctM-like transporters; Region: DctM; pfam06808 911045014781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014782 Transcriptional regulators [Transcription]; Region: GntR; COG1802 911045014783 DNA-binding site [nucleotide binding]; DNA binding site 911045014784 FCD domain; Region: FCD; pfam07729 911045014785 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 911045014786 BCCT family transporter; Region: BCCT; pfam02028 911045014787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 911045014788 DNA-binding site [nucleotide binding]; DNA binding site 911045014789 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 911045014790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045014791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045014792 homodimer interface [polypeptide binding]; other site 911045014793 catalytic residue [active] 911045014794 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 911045014795 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045014796 substrate binding site [chemical binding]; other site 911045014797 oxyanion hole (OAH) forming residues; other site 911045014798 trimer interface [polypeptide binding]; other site 911045014799 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 911045014800 Coenzyme A transferase; Region: CoA_trans; smart00882 911045014801 Coenzyme A transferase; Region: CoA_trans; cl17247 911045014802 Uncharacterized conserved protein [Function unknown]; Region: COG4104 911045014803 D123; Region: D123; pfam07065 911045014804 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 911045014805 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 911045014806 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 911045014807 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 911045014808 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 911045014809 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 911045014810 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 911045014811 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 911045014812 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 911045014813 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045014814 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 911045014815 enoyl-CoA hydratase; Provisional; Region: PRK08138 911045014816 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045014817 substrate binding site [chemical binding]; other site 911045014818 oxyanion hole (OAH) forming residues; other site 911045014819 trimer interface [polypeptide binding]; other site 911045014820 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 911045014821 CoA-transferase family III; Region: CoA_transf_3; pfam02515 911045014822 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045014823 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045014824 DNA binding site [nucleotide binding] 911045014825 domain linker motif; other site 911045014826 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045014827 dimerization interface [polypeptide binding]; other site 911045014828 ligand binding site [chemical binding]; other site 911045014829 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045014830 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045014831 DctM-like transporters; Region: DctM; pfam06808 911045014832 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045014833 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 911045014834 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 911045014835 classical (c) SDRs; Region: SDR_c; cd05233 911045014836 NAD(P) binding site [chemical binding]; other site 911045014837 active site 911045014838 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 911045014839 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 911045014840 putative NAD(P) binding site [chemical binding]; other site 911045014841 catalytic Zn binding site [ion binding]; other site 911045014842 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 911045014843 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 911045014844 substrate binding site [chemical binding]; other site 911045014845 ATP binding site [chemical binding]; other site 911045014846 BCCT family transporter; Region: BCCT; pfam02028 911045014847 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 911045014848 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 911045014849 protein-splicing catalytic site; other site 911045014850 thioester formation/cholesterol transfer; other site 911045014851 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 911045014852 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 911045014853 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 911045014854 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 911045014855 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 911045014856 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 911045014857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045014858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045014859 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 911045014860 Protein of unknown function (DUF962); Region: DUF962; pfam06127 911045014861 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 911045014862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045014863 Coenzyme A binding pocket [chemical binding]; other site 911045014864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 911045014865 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 911045014866 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045014867 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 911045014868 DNA binding residues [nucleotide binding] 911045014869 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 911045014870 FecR protein; Region: FecR; pfam04773 911045014871 Secretin and TonB N terminus short domain; Region: STN; smart00965 911045014872 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 911045014873 malonyl-CoA synthase; Validated; Region: PRK07514 911045014874 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 911045014875 acyl-activating enzyme (AAE) consensus motif; other site 911045014876 active site 911045014877 AMP binding site [chemical binding]; other site 911045014878 CoA binding site [chemical binding]; other site 911045014879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045014880 S-adenosylmethionine binding site [chemical binding]; other site 911045014881 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 911045014882 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 911045014883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045014884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045014885 DNA binding residues [nucleotide binding] 911045014886 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 911045014887 Uncharacterized conserved protein [Function unknown]; Region: COG2128 911045014888 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045014889 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045014890 putative S-transferase; Provisional; Region: PRK11752 911045014891 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 911045014892 C-terminal domain interface [polypeptide binding]; other site 911045014893 GSH binding site (G-site) [chemical binding]; other site 911045014894 dimer interface [polypeptide binding]; other site 911045014895 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 911045014896 dimer interface [polypeptide binding]; other site 911045014897 N-terminal domain interface [polypeptide binding]; other site 911045014898 active site 911045014899 hypothetical protein; Provisional; Region: PRK10977 911045014900 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 911045014901 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 911045014902 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 911045014903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 911045014904 FeS/SAM binding site; other site 911045014905 Cupin; Region: Cupin_6; pfam12852 911045014906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045014907 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045014908 Isochorismatase family; Region: Isochorismatase; pfam00857 911045014909 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 911045014910 catalytic triad [active] 911045014911 conserved cis-peptide bond; other site 911045014912 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 911045014913 classical (c) SDRs; Region: SDR_c; cd05233 911045014914 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 911045014915 NAD(P) binding site [chemical binding]; other site 911045014916 active site 911045014917 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 911045014918 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045014919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014920 dimer interface [polypeptide binding]; other site 911045014921 conserved gate region; other site 911045014922 putative PBP binding loops; other site 911045014923 ABC-ATPase subunit interface; other site 911045014924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045014925 dimer interface [polypeptide binding]; other site 911045014926 conserved gate region; other site 911045014927 putative PBP binding loops; other site 911045014928 ABC-ATPase subunit interface; other site 911045014929 hypothetical protein; Provisional; Region: PRK11622 911045014930 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045014931 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 911045014932 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 911045014933 Walker A/P-loop; other site 911045014934 ATP binding site [chemical binding]; other site 911045014935 Q-loop/lid; other site 911045014936 ABC transporter signature motif; other site 911045014937 Walker B; other site 911045014938 D-loop; other site 911045014939 H-loop/switch region; other site 911045014940 TOBE domain; Region: TOBE_2; pfam08402 911045014941 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 911045014942 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 911045014943 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 911045014944 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 911045014945 PhoU domain; Region: PhoU; pfam01895 911045014946 PhoU domain; Region: PhoU; pfam01895 911045014947 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 911045014948 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 911045014949 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 911045014950 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 911045014951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 911045014952 non-specific DNA binding site [nucleotide binding]; other site 911045014953 salt bridge; other site 911045014954 sequence-specific DNA binding site [nucleotide binding]; other site 911045014955 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 911045014956 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 911045014957 active site 911045014958 8-oxo-dGMP binding site [chemical binding]; other site 911045014959 nudix motif; other site 911045014960 metal binding site [ion binding]; metal-binding site 911045014961 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 911045014962 RF-1 domain; Region: RF-1; cl17422 911045014963 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 911045014964 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045014965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045014966 NAD(P) binding site [chemical binding]; other site 911045014967 active site 911045014968 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 911045014969 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 911045014970 nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; Region: SLC-NCS1sbd_Mhp1-like; cd11483 911045014971 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 911045014972 Na binding site [ion binding]; other site 911045014973 substrate binding site [chemical binding]; other site 911045014974 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045014975 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045014976 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 911045014977 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 911045014978 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 911045014979 malonyl-CoA binding site [chemical binding]; other site 911045014980 dimer interface [polypeptide binding]; other site 911045014981 active site 911045014982 product binding site; other site 911045014983 Phospholipid methyltransferase; Region: PEMT; cl17370 911045014984 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 911045014985 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 911045014986 dimer interface [polypeptide binding]; other site 911045014987 NADP binding site [chemical binding]; other site 911045014988 catalytic residues [active] 911045014989 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 911045014990 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 911045014991 Walker A/P-loop; other site 911045014992 ATP binding site [chemical binding]; other site 911045014993 Q-loop/lid; other site 911045014994 ABC transporter signature motif; other site 911045014995 Walker B; other site 911045014996 D-loop; other site 911045014997 H-loop/switch region; other site 911045014998 TOBE domain; Region: TOBE_2; pfam08402 911045014999 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 911045015000 putative catalytic site [active] 911045015001 putative metal binding site [ion binding]; other site 911045015002 putative phosphate binding site [ion binding]; other site 911045015003 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045015004 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045015005 DNA binding site [nucleotide binding] 911045015006 domain linker motif; other site 911045015007 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045015008 dimerization interface [polypeptide binding]; other site 911045015009 ligand binding site [chemical binding]; other site 911045015010 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 911045015011 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 911045015012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045015013 dimer interface [polypeptide binding]; other site 911045015014 conserved gate region; other site 911045015015 putative PBP binding loops; other site 911045015016 ABC-ATPase subunit interface; other site 911045015017 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 911045015018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045015019 dimer interface [polypeptide binding]; other site 911045015020 conserved gate region; other site 911045015021 putative PBP binding loops; other site 911045015022 ABC-ATPase subunit interface; other site 911045015023 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 911045015024 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 911045015025 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 911045015026 Fic family protein [Function unknown]; Region: COG3177 911045015027 Fic/DOC family; Region: Fic; pfam02661 911045015028 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 911045015029 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 911045015030 active site 911045015031 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 911045015032 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 911045015033 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 911045015034 Enoylreductase; Region: PKS_ER; smart00829 911045015035 NAD(P) binding site [chemical binding]; other site 911045015036 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 911045015037 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 911045015038 putative NADP binding site [chemical binding]; other site 911045015039 active site 911045015040 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 911045015041 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 911045015042 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 911045015043 substrate-cofactor binding pocket; other site 911045015044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045015045 catalytic residue [active] 911045015046 short chain dehydrogenase; Provisional; Region: PRK07024 911045015047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045015048 NAD(P) binding site [chemical binding]; other site 911045015049 active site 911045015050 Vi polysaccharide export protein VexA; Provisional; Region: PRK15175 911045015051 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 911045015052 SLBB domain; Region: SLBB; pfam10531 911045015053 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 911045015054 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 911045015055 Walker A/P-loop; other site 911045015056 ATP binding site [chemical binding]; other site 911045015057 ABC transporter; Region: ABC_tran; pfam00005 911045015058 Q-loop/lid; other site 911045015059 ABC transporter signature motif; other site 911045015060 Walker B; other site 911045015061 D-loop; other site 911045015062 H-loop/switch region; other site 911045015063 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 911045015064 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 911045015065 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 911045015066 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 911045015067 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 911045015068 active site 911045015069 cosubstrate binding site; other site 911045015070 substrate binding site [chemical binding]; other site 911045015071 catalytic site [active] 911045015072 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045015073 EamA-like transporter family; Region: EamA; pfam00892 911045015074 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 911045015075 Cytochrome P450; Region: p450; cl12078 911045015076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045015077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045015078 Coenzyme A binding pocket [chemical binding]; other site 911045015079 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 911045015080 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 911045015081 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 911045015082 probable polyamine oxidase; Region: PLN02268 911045015083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 911045015084 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 911045015085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 911045015086 active site 911045015087 motif I; other site 911045015088 motif II; other site 911045015089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045015090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045015091 DNA binding site [nucleotide binding] 911045015092 domain linker motif; other site 911045015093 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045015094 dimerization interface [polypeptide binding]; other site 911045015095 ligand binding site [chemical binding]; other site 911045015096 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 911045015097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045015098 Walker A/P-loop; other site 911045015099 ATP binding site [chemical binding]; other site 911045015100 Q-loop/lid; other site 911045015101 ABC transporter signature motif; other site 911045015102 Walker B; other site 911045015103 D-loop; other site 911045015104 H-loop/switch region; other site 911045015105 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045015106 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045015107 Walker A/P-loop; other site 911045015108 ATP binding site [chemical binding]; other site 911045015109 Q-loop/lid; other site 911045015110 ABC transporter signature motif; other site 911045015111 Walker B; other site 911045015112 D-loop; other site 911045015113 H-loop/switch region; other site 911045015114 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 911045015115 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 911045015116 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 911045015117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045015118 dimer interface [polypeptide binding]; other site 911045015119 conserved gate region; other site 911045015120 putative PBP binding loops; other site 911045015121 ABC-ATPase subunit interface; other site 911045015122 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045015123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045015124 dimer interface [polypeptide binding]; other site 911045015125 conserved gate region; other site 911045015126 putative PBP binding loops; other site 911045015127 ABC-ATPase subunit interface; other site 911045015128 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045015129 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 911045015130 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 911045015131 Transcriptional regulators [Transcription]; Region: PurR; COG1609 911045015132 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 911045015133 DNA binding site [nucleotide binding] 911045015134 domain linker motif; other site 911045015135 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 911045015136 dimerization interface [polypeptide binding]; other site 911045015137 ligand binding site [chemical binding]; other site 911045015138 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 911045015139 conserved cys residue [active] 911045015140 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 911045015141 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 911045015142 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 911045015143 PAS domain; Region: PAS_9; pfam13426 911045015144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045015145 putative active site [active] 911045015146 heme pocket [chemical binding]; other site 911045015147 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 911045015148 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 911045015149 metal binding site [ion binding]; metal-binding site 911045015150 active site 911045015151 I-site; other site 911045015152 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 911045015153 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 911045015154 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 911045015155 EamA-like transporter family; Region: EamA; pfam00892 911045015156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 911045015157 putative DNA binding site [nucleotide binding]; other site 911045015158 putative Zn2+ binding site [ion binding]; other site 911045015159 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 911045015160 putative hydrophobic ligand binding site [chemical binding]; other site 911045015161 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 911045015162 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 911045015163 putative metal binding site; other site 911045015164 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 911045015165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 911045015166 active site 911045015167 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 911045015168 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 911045015169 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 911045015170 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045015171 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 911045015172 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 911045015173 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 911045015174 Sulfatase; Region: Sulfatase; cl17466 911045015175 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 911045015176 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045015177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045015178 dimer interface [polypeptide binding]; other site 911045015179 putative CheW interface [polypeptide binding]; other site 911045015180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 911045015181 PAS fold; Region: PAS_3; pfam08447 911045015182 putative active site [active] 911045015183 heme pocket [chemical binding]; other site 911045015184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 911045015185 dimerization interface [polypeptide binding]; other site 911045015186 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 911045015187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 911045015188 dimer interface [polypeptide binding]; other site 911045015189 putative CheW interface [polypeptide binding]; other site 911045015190 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 911045015191 active site 911045015192 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 911045015193 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 911045015194 putative active site [active] 911045015195 metal binding site [ion binding]; metal-binding site 911045015196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045015197 putative substrate translocation pore; other site 911045015198 H+ Antiporter protein; Region: 2A0121; TIGR00900 911045015199 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608 911045015200 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 911045015201 Coenzyme A transferase; Region: CoA_trans; smart00882 911045015202 Coenzyme A transferase; Region: CoA_trans; cl17247 911045015203 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 911045015204 homotrimer interaction site [polypeptide binding]; other site 911045015205 putative active site [active] 911045015206 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 911045015207 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 911045015208 NADP binding site [chemical binding]; other site 911045015209 active site 911045015210 putative substrate binding site [chemical binding]; other site 911045015211 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 911045015212 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 911045015213 NADP-binding site; other site 911045015214 homotetramer interface [polypeptide binding]; other site 911045015215 substrate binding site [chemical binding]; other site 911045015216 homodimer interface [polypeptide binding]; other site 911045015217 active site 911045015218 putative chaperone; Provisional; Region: PRK11678 911045015219 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 911045015220 nucleotide binding site [chemical binding]; other site 911045015221 putative NEF/HSP70 interaction site [polypeptide binding]; other site 911045015222 SBD interface [polypeptide binding]; other site 911045015223 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045015224 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045015225 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045015226 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 911045015227 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 911045015228 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 911045015229 N-terminal domain interface [polypeptide binding]; other site 911045015230 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 911045015231 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 911045015232 tetramer interface [polypeptide binding]; other site 911045015233 active site 911045015234 Mg2+/Mn2+ binding site [ion binding]; other site 911045015235 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 911045015236 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 911045015237 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 911045015238 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 911045015239 DNA binding site [nucleotide binding] 911045015240 active site 911045015241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045015242 Coenzyme A binding pocket [chemical binding]; other site 911045015243 Replication protein C N-terminal domain; Region: RP-C; pfam03428 911045015244 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 911045015245 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 911045015246 ParB-like nuclease domain; Region: ParBc; pfam02195 911045015247 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 911045015248 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 911045015249 DNA binding residues [nucleotide binding] 911045015250 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 911045015251 P-loop; other site 911045015252 Magnesium ion binding site [ion binding]; other site 911045015253 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 911045015254 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 911045015255 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 911045015256 classical (c) SDRs; Region: SDR_c; cd05233 911045015257 NAD(P) binding site [chemical binding]; other site 911045015258 active site 911045015259 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 911045015260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 911045015261 Coenzyme A binding pocket [chemical binding]; other site 911045015262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045015263 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 911045015264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045015265 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 911045015266 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 911045015267 tetramer interface [polypeptide binding]; other site 911045015268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045015269 catalytic residue [active] 911045015270 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 911045015271 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 911045015272 short chain dehydrogenase; Validated; Region: PRK06182 911045015273 NADP binding site [chemical binding]; other site 911045015274 active site 911045015275 steroid binding site; other site 911045015276 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 911045015277 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 911045015278 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 911045015279 dimer interface [polypeptide binding]; other site 911045015280 PYR/PP interface [polypeptide binding]; other site 911045015281 TPP binding site [chemical binding]; other site 911045015282 substrate binding site [chemical binding]; other site 911045015283 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 911045015284 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 911045015285 TPP-binding site [chemical binding]; other site 911045015286 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 911045015287 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 911045015288 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 911045015289 DNA binding residues [nucleotide binding] 911045015290 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 911045015291 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 911045015292 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 911045015293 N-terminal domain interface [polypeptide binding]; other site 911045015294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 911045015295 S-adenosylmethionine binding site [chemical binding]; other site 911045015296 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 911045015297 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 911045015298 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 911045015299 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 911045015300 NnrS protein; Region: NnrS; pfam05940 911045015301 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 911045015302 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 911045015303 DNA binding residues [nucleotide binding] 911045015304 dimerization interface [polypeptide binding]; other site 911045015305 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 911045015306 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 911045015307 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045015308 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 911045015309 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045015310 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045015311 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 911045015312 homotrimer interaction site [polypeptide binding]; other site 911045015313 putative active site [active] 911045015314 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 911045015315 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 911045015316 homodimer interface [polypeptide binding]; other site 911045015317 ligand binding site [chemical binding]; other site 911045015318 NAD(P) binding site [chemical binding]; other site 911045015319 trimer interface B [polypeptide binding]; other site 911045015320 trimer interface A [polypeptide binding]; other site 911045015321 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 911045015322 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 911045015323 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 911045015324 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 911045015325 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 911045015326 acyl-activating enzyme (AAE) consensus motif; other site 911045015327 AMP binding site [chemical binding]; other site 911045015328 enoyl-CoA hydratase; Provisional; Region: PRK05862 911045015329 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 911045015330 substrate binding site [chemical binding]; other site 911045015331 oxyanion hole (OAH) forming residues; other site 911045015332 trimer interface [polypeptide binding]; other site 911045015333 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045015334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045015335 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 911045015336 putative effector binding pocket; other site 911045015337 putative dimerization interface [polypeptide binding]; other site 911045015338 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 911045015339 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 911045015340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 911045015341 SnoaL-like domain; Region: SnoaL_2; pfam12680 911045015342 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 911045015343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 911045015344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045015345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 911045015346 dimerization interface [polypeptide binding]; other site 911045015347 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045015348 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045015349 DctM-like transporters; Region: DctM; pfam06808 911045015350 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045015351 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045015352 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 911045015353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 911045015354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 911045015355 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 911045015356 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045015357 hydroxyglutarate oxidase; Provisional; Region: PRK11728 911045015358 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 911045015359 homotrimer interaction site [polypeptide binding]; other site 911045015360 putative active site [active] 911045015361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 911045015362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 911045015363 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 911045015364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 911045015365 active site 911045015366 phosphorylation site [posttranslational modification] 911045015367 intermolecular recognition site; other site 911045015368 dimerization interface [polypeptide binding]; other site 911045015369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 911045015370 DNA binding site [nucleotide binding] 911045015371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 911045015372 HAMP domain; Region: HAMP; pfam00672 911045015373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 911045015374 dimer interface [polypeptide binding]; other site 911045015375 phosphorylation site [posttranslational modification] 911045015376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 911045015377 ATP binding site [chemical binding]; other site 911045015378 Mg2+ binding site [ion binding]; other site 911045015379 G-X-G motif; other site 911045015380 intracellular protease, PfpI family; Region: PfpI; TIGR01382 911045015381 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 911045015382 conserved cys residue [active] 911045015383 tyramine oxidase; Provisional; Region: tynA; PRK11504 911045015384 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 911045015385 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 911045015386 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 911045015387 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 911045015388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 911045015389 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 911045015390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 911045015391 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 911045015392 putative dimerization interface [polypeptide binding]; other site 911045015393 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 911045015394 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 911045015395 gating phenylalanine in ion channel; other site 911045015396 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 911045015397 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 911045015398 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 911045015399 putative active site [active] 911045015400 N-formylglutamate amidohydrolase; Region: FGase; cl01522 911045015401 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 911045015402 DctM-like transporters; Region: DctM; pfam06808 911045015403 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045015404 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045015405 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 911045015406 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 911045015407 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 911045015408 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 911045015409 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 911045015410 NAD(P) binding site [chemical binding]; other site 911045015411 catalytic residues [active] 911045015412 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 911045015413 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 911045015414 putative active site [active] 911045015415 metal binding site [ion binding]; metal-binding site 911045015416 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 911045015417 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 911045015418 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 911045015419 active site 911045015420 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 911045015421 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045015422 Walker A/P-loop; other site 911045015423 ATP binding site [chemical binding]; other site 911045015424 Q-loop/lid; other site 911045015425 ABC transporter signature motif; other site 911045015426 Walker B; other site 911045015427 D-loop; other site 911045015428 H-loop/switch region; other site 911045015429 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 911045015430 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 911045015431 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 911045015432 Walker A/P-loop; other site 911045015433 ATP binding site [chemical binding]; other site 911045015434 Q-loop/lid; other site 911045015435 ABC transporter signature motif; other site 911045015436 Walker B; other site 911045015437 D-loop; other site 911045015438 H-loop/switch region; other site 911045015439 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 911045015440 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 911045015441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045015442 dimer interface [polypeptide binding]; other site 911045015443 conserved gate region; other site 911045015444 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 911045015445 ABC-ATPase subunit interface; other site 911045015446 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 911045015447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 911045015448 dimer interface [polypeptide binding]; other site 911045015449 conserved gate region; other site 911045015450 putative PBP binding loops; other site 911045015451 ABC-ATPase subunit interface; other site 911045015452 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 911045015453 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 911045015454 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 911045015455 maleylacetoacetate isomerase; Region: maiA; TIGR01262 911045015456 C-terminal domain interface [polypeptide binding]; other site 911045015457 GSH binding site (G-site) [chemical binding]; other site 911045015458 putative dimer interface [polypeptide binding]; other site 911045015459 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 911045015460 dimer interface [polypeptide binding]; other site 911045015461 N-terminal domain interface [polypeptide binding]; other site 911045015462 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 911045015463 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 911045015464 MarR family; Region: MarR_2; pfam12802 911045015465 MarR family; Region: MarR_2; cl17246 911045015466 fumarylacetoacetase; Region: PLN02856 911045015467 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 911045015468 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 911045015469 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 911045015470 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 911045015471 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 911045015472 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 911045015473 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 911045015474 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 911045015475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 911045015476 Zn binding site [ion binding]; other site 911045015477 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045015478 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045015479 DctM-like transporters; Region: DctM; pfam06808 911045015480 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045015481 FAD dependent oxidoreductase; Region: DAO; pfam01266 911045015482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 911045015483 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 911045015484 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 911045015485 active site 911045015486 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 911045015487 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 911045015488 tetramer interface [polypeptide binding]; other site 911045015489 active site 911045015490 Mg2+/Mn2+ binding site [ion binding]; other site 911045015491 DctM-like transporters; Region: DctM; pfam06808 911045015492 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 911045015493 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045015494 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045015495 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045015496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 911045015497 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 911045015498 NAD(P) binding site [chemical binding]; other site 911045015499 active site 911045015500 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 911045015501 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 911045015502 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 911045015503 Subunit I/III interface [polypeptide binding]; other site 911045015504 Subunit III/IV interface [polypeptide binding]; other site 911045015505 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 911045015506 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 911045015507 D-pathway; other site 911045015508 Putative ubiquinol binding site [chemical binding]; other site 911045015509 Low-spin heme (heme b) binding site [chemical binding]; other site 911045015510 Putative water exit pathway; other site 911045015511 Binuclear center (heme o3/CuB) [ion binding]; other site 911045015512 K-pathway; other site 911045015513 Putative proton exit pathway; other site 911045015514 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 911045015515 Serpentine type 7TM GPCR chemoreceptor Srv; Region: 7TM_GPCR_Srv; pfam10323 911045015516 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 911045015517 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 911045015518 SnoaL-like domain; Region: SnoaL_2; pfam12680 911045015519 Cytochrome P450; Region: p450; cl12078 911045015520 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 911045015521 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 911045015522 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 911045015523 active site 911045015524 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045015525 TAP-like protein; Region: Abhydrolase_4; pfam08386 911045015526 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 911045015527 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 911045015528 active site 911045015529 nucleophile elbow; other site 911045015530 Patatin phospholipase; Region: DUF3734; pfam12536 911045015531 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 911045015532 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 911045015533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 911045015534 putative substrate translocation pore; other site 911045015535 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 911045015536 homotrimer interaction site [polypeptide binding]; other site 911045015537 putative active site [active] 911045015538 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 911045015539 Beta-lactamase; Region: Beta-lactamase; pfam00144 911045015540 aspartate aminotransferase; Provisional; Region: PRK06108 911045015541 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 911045015542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 911045015543 homodimer interface [polypeptide binding]; other site 911045015544 catalytic residue [active] 911045015545 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 911045015546 HlyD family secretion protein; Region: HlyD_3; pfam13437 911045015547 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 911045015548 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 911045015549 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 911045015550 Walker A/P-loop; other site 911045015551 ATP binding site [chemical binding]; other site 911045015552 Q-loop/lid; other site 911045015553 ABC transporter signature motif; other site 911045015554 Walker B; other site 911045015555 D-loop; other site 911045015556 H-loop/switch region; other site 911045015557 DctM-like transporters; Region: DctM; pfam06808 911045015558 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 911045015559 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 911045015560 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 911045015561 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 911045015562 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 911045015563 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 911045015564 substrate binding pocket [chemical binding]; other site