-- dump date 20140620_020644 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1045855000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1045855000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1045855000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855000004 Walker A motif; other site 1045855000005 ATP binding site [chemical binding]; other site 1045855000006 Walker B motif; other site 1045855000007 arginine finger; other site 1045855000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1045855000009 DnaA box-binding interface [nucleotide binding]; other site 1045855000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1045855000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1045855000012 putative DNA binding surface [nucleotide binding]; other site 1045855000013 dimer interface [polypeptide binding]; other site 1045855000014 beta-clamp/clamp loader binding surface; other site 1045855000015 beta-clamp/translesion DNA polymerase binding surface; other site 1045855000016 recombination protein F; Reviewed; Region: recF; PRK00064 1045855000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855000018 Walker A/P-loop; other site 1045855000019 ATP binding site [chemical binding]; other site 1045855000020 Q-loop/lid; other site 1045855000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855000022 ABC transporter signature motif; other site 1045855000023 Walker B; other site 1045855000024 D-loop; other site 1045855000025 H-loop/switch region; other site 1045855000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1045855000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855000028 Mg2+ binding site [ion binding]; other site 1045855000029 G-X-G motif; other site 1045855000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1045855000031 anchoring element; other site 1045855000032 dimer interface [polypeptide binding]; other site 1045855000033 ATP binding site [chemical binding]; other site 1045855000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1045855000035 active site 1045855000036 putative metal-binding site [ion binding]; other site 1045855000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1045855000038 CAAX protease self-immunity; Region: Abi; pfam02517 1045855000039 Peptidase family M48; Region: Peptidase_M48; pfam01435 1045855000040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855000041 binding surface 1045855000042 TPR motif; other site 1045855000043 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1045855000044 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1045855000045 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1045855000046 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1045855000047 TolR protein; Region: tolR; TIGR02801 1045855000048 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1045855000049 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1045855000050 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1045855000051 active site 1045855000052 hydrophilic channel; other site 1045855000053 dimerization interface [polypeptide binding]; other site 1045855000054 catalytic residues [active] 1045855000055 active site lid [active] 1045855000056 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1045855000057 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1045855000058 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1045855000059 putative active site [active] 1045855000060 catalytic site [active] 1045855000061 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1045855000062 putative active site [active] 1045855000063 catalytic site [active] 1045855000064 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1045855000065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045855000066 FeS/SAM binding site; other site 1045855000067 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1045855000068 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1045855000069 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1045855000070 serine racemase; Region: PLN02970 1045855000071 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1045855000072 tetramer interface [polypeptide binding]; other site 1045855000073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855000074 catalytic residue [active] 1045855000075 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1045855000076 putative active site [active] 1045855000077 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1045855000078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855000079 S-adenosylmethionine binding site [chemical binding]; other site 1045855000080 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1045855000081 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1045855000082 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855000083 catalytic residue [active] 1045855000084 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1045855000085 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1045855000086 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1045855000087 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1045855000088 UbiA prenyltransferase family; Region: UbiA; pfam01040 1045855000089 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1045855000090 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855000091 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045855000092 ligand-binding site [chemical binding]; other site 1045855000093 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1045855000094 dimer interface [polypeptide binding]; other site 1045855000095 FMN binding site [chemical binding]; other site 1045855000096 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1045855000097 catalytic residues [active] 1045855000098 dimer interface [polypeptide binding]; other site 1045855000099 VacJ like lipoprotein; Region: VacJ; cl01073 1045855000100 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1045855000101 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1045855000102 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1045855000103 mce related protein; Region: MCE; pfam02470 1045855000104 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1045855000105 Permease; Region: Permease; pfam02405 1045855000106 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1045855000107 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1045855000108 Walker A/P-loop; other site 1045855000109 ATP binding site [chemical binding]; other site 1045855000110 Q-loop/lid; other site 1045855000111 ABC transporter signature motif; other site 1045855000112 Walker B; other site 1045855000113 D-loop; other site 1045855000114 H-loop/switch region; other site 1045855000115 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1045855000116 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1045855000117 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1045855000118 Family description; Region: UvrD_C_2; pfam13538 1045855000119 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1045855000120 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1045855000121 AAA domain; Region: AAA_30; pfam13604 1045855000122 Family description; Region: UvrD_C_2; pfam13538 1045855000123 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1045855000124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855000125 active site 1045855000126 phosphorylation site [posttranslational modification] 1045855000127 intermolecular recognition site; other site 1045855000128 dimerization interface [polypeptide binding]; other site 1045855000129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855000130 DNA binding site [nucleotide binding] 1045855000131 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1045855000132 HAMP domain; Region: HAMP; pfam00672 1045855000133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855000134 dimer interface [polypeptide binding]; other site 1045855000135 phosphorylation site [posttranslational modification] 1045855000136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855000137 ATP binding site [chemical binding]; other site 1045855000138 Mg2+ binding site [ion binding]; other site 1045855000139 G-X-G motif; other site 1045855000140 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1045855000141 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1045855000142 putative NAD(P) binding site [chemical binding]; other site 1045855000143 dimer interface [polypeptide binding]; other site 1045855000144 RmuC family; Region: RmuC; pfam02646 1045855000145 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1045855000146 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 1045855000147 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1045855000148 allophanate hydrolase; Provisional; Region: PRK08186 1045855000149 Amidase; Region: Amidase; cl11426 1045855000150 urea carboxylase; Region: urea_carbox; TIGR02712 1045855000151 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045855000152 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045855000153 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1045855000154 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1045855000155 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1045855000156 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1045855000157 carboxyltransferase (CT) interaction site; other site 1045855000158 biotinylation site [posttranslational modification]; other site 1045855000159 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1045855000160 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1045855000161 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1045855000162 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1045855000163 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1045855000164 Walker A/P-loop; other site 1045855000165 ATP binding site [chemical binding]; other site 1045855000166 Q-loop/lid; other site 1045855000167 ABC transporter signature motif; other site 1045855000168 Walker B; other site 1045855000169 D-loop; other site 1045855000170 H-loop/switch region; other site 1045855000171 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1045855000172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855000173 putative PBP binding loops; other site 1045855000174 dimer interface [polypeptide binding]; other site 1045855000175 ABC-ATPase subunit interface; other site 1045855000176 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1045855000177 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1045855000178 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1045855000179 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1045855000180 trimer interface [polypeptide binding]; other site 1045855000181 putative metal binding site [ion binding]; other site 1045855000182 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1045855000183 putative catalytic site [active] 1045855000184 putative phosphate binding site [ion binding]; other site 1045855000185 active site 1045855000186 metal binding site A [ion binding]; metal-binding site 1045855000187 DNA binding site [nucleotide binding] 1045855000188 putative AP binding site [nucleotide binding]; other site 1045855000189 putative metal binding site B [ion binding]; other site 1045855000190 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1045855000191 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1045855000192 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1045855000193 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1045855000194 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1045855000195 P-loop; other site 1045855000196 Magnesium ion binding site [ion binding]; other site 1045855000197 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045855000198 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1045855000199 Magnesium ion binding site [ion binding]; other site 1045855000200 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1045855000201 ParB-like nuclease domain; Region: ParBc; pfam02195 1045855000202 KorB domain; Region: KorB; pfam08535 1045855000203 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045855000204 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045855000205 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 1045855000206 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1045855000207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045855000208 DNA-binding site [nucleotide binding]; DNA binding site 1045855000209 UTRA domain; Region: UTRA; pfam07702 1045855000210 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1045855000211 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1045855000212 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1045855000213 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1045855000214 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1045855000215 putative active site [active] 1045855000216 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1045855000217 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1045855000218 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1045855000219 Di-iron ligands [ion binding]; other site 1045855000220 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1045855000221 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1045855000222 Walker A/P-loop; other site 1045855000223 ATP binding site [chemical binding]; other site 1045855000224 Q-loop/lid; other site 1045855000225 ABC transporter signature motif; other site 1045855000226 Walker B; other site 1045855000227 D-loop; other site 1045855000228 H-loop/switch region; other site 1045855000229 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1045855000230 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1045855000231 DNA binding site [nucleotide binding] 1045855000232 catalytic residue [active] 1045855000233 H2TH interface [polypeptide binding]; other site 1045855000234 putative catalytic residues [active] 1045855000235 turnover-facilitating residue; other site 1045855000236 intercalation triad [nucleotide binding]; other site 1045855000237 8OG recognition residue [nucleotide binding]; other site 1045855000238 putative reading head residues; other site 1045855000239 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1045855000240 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1045855000241 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 1045855000242 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1045855000243 DNA binding residues [nucleotide binding] 1045855000244 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1045855000245 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1045855000246 active site 1045855000247 ATP binding site [chemical binding]; other site 1045855000248 substrate binding site [chemical binding]; other site 1045855000249 activation loop (A-loop); other site 1045855000250 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045855000251 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045855000252 thymidine kinase; Provisional; Region: PRK04296 1045855000253 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1045855000254 Part of AAA domain; Region: AAA_19; pfam13245 1045855000255 Family description; Region: UvrD_C_2; pfam13538 1045855000256 Integrase core domain; Region: rve_3; cl15866 1045855000257 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1045855000258 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1045855000259 Protein of unknown function, DUF480; Region: DUF480; cl01209 1045855000260 hypothetical protein; Provisional; Region: PRK11239 1045855000261 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1045855000262 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1045855000263 active site 1045855000264 dimer interface [polypeptide binding]; other site 1045855000265 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1045855000266 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1045855000267 putative acyl-acceptor binding pocket; other site 1045855000268 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 1045855000269 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1045855000270 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1045855000271 Ligand Binding Site [chemical binding]; other site 1045855000272 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1045855000273 Protein of unknown function DUF45; Region: DUF45; pfam01863 1045855000274 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045855000275 ferrochelatase; Reviewed; Region: hemH; PRK00035 1045855000276 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1045855000277 C-terminal domain interface [polypeptide binding]; other site 1045855000278 active site 1045855000279 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1045855000280 active site 1045855000281 N-terminal domain interface [polypeptide binding]; other site 1045855000282 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 1045855000283 putative amphipathic alpha helix; other site 1045855000284 twin arginine translocase protein A; Provisional; Region: tatA; PRK04561 1045855000285 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1045855000286 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1045855000287 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1045855000288 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1045855000289 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1045855000290 Walker A motif; other site 1045855000291 ATP binding site [chemical binding]; other site 1045855000292 Walker B motif; other site 1045855000293 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1045855000294 dimer interface [polypeptide binding]; other site 1045855000295 motif 1; other site 1045855000296 active site 1045855000297 motif 2; other site 1045855000298 motif 3; other site 1045855000299 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1045855000300 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1045855000301 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1045855000302 dimer interface [polypeptide binding]; other site 1045855000303 N-terminal domain interface [polypeptide binding]; other site 1045855000304 putative substrate binding pocket (H-site) [chemical binding]; other site 1045855000305 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1045855000306 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1045855000307 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045855000308 Surface antigen; Region: Bac_surface_Ag; pfam01103 1045855000309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1045855000310 Family of unknown function (DUF490); Region: DUF490; pfam04357 1045855000311 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1045855000312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855000313 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045855000314 putative substrate translocation pore; other site 1045855000315 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1045855000316 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1045855000317 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1045855000318 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1045855000319 RNA binding site [nucleotide binding]; other site 1045855000320 Transposase IS200 like; Region: Y1_Tnp; cl00848 1045855000321 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1045855000322 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 1045855000323 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1045855000324 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1045855000325 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1045855000326 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1045855000327 active site 1045855000328 catalytic residue [active] 1045855000329 dimer interface [polypeptide binding]; other site 1045855000330 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1045855000331 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1045855000332 BON domain; Region: BON; pfam04972 1045855000333 BON domain; Region: BON; pfam04972 1045855000334 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1045855000335 Amidinotransferase; Region: Amidinotransf; cl12043 1045855000336 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1045855000337 HTH domain; Region: HTH_11; cl17392 1045855000338 AsnC family; Region: AsnC_trans_reg; pfam01037 1045855000339 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1045855000340 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045855000341 Walker A/P-loop; other site 1045855000342 ATP binding site [chemical binding]; other site 1045855000343 Q-loop/lid; other site 1045855000344 ABC transporter signature motif; other site 1045855000345 Walker B; other site 1045855000346 D-loop; other site 1045855000347 H-loop/switch region; other site 1045855000348 Predicted transcriptional regulators [Transcription]; Region: COG1725 1045855000349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045855000350 DNA-binding site [nucleotide binding]; DNA binding site 1045855000351 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1045855000352 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1045855000353 AMP binding site [chemical binding]; other site 1045855000354 metal binding site [ion binding]; metal-binding site 1045855000355 active site 1045855000356 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1045855000357 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1045855000358 active site 1045855000359 substrate binding site [chemical binding]; other site 1045855000360 FMN binding site [chemical binding]; other site 1045855000361 putative catalytic residues [active] 1045855000362 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1045855000363 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045855000364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855000365 homodimer interface [polypeptide binding]; other site 1045855000366 catalytic residue [active] 1045855000367 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1045855000368 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1045855000369 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045855000370 N-terminal plug; other site 1045855000371 ligand-binding site [chemical binding]; other site 1045855000372 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1045855000373 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1045855000374 NAD(P) binding site [chemical binding]; other site 1045855000375 catalytic residues [active] 1045855000376 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1045855000377 GAF domain; Region: GAF; pfam01590 1045855000378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855000379 Walker A motif; other site 1045855000380 ATP binding site [chemical binding]; other site 1045855000381 Walker B motif; other site 1045855000382 arginine finger; other site 1045855000383 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1045855000384 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1045855000385 cofactor binding site; other site 1045855000386 metal binding site [ion binding]; metal-binding site 1045855000387 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1045855000388 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1045855000389 putative DNA binding site [nucleotide binding]; other site 1045855000390 putative Zn2+ binding site [ion binding]; other site 1045855000391 AsnC family; Region: AsnC_trans_reg; pfam01037 1045855000392 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1045855000393 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1045855000394 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1045855000395 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1045855000396 putative RNA binding site [nucleotide binding]; other site 1045855000397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855000398 S-adenosylmethionine binding site [chemical binding]; other site 1045855000399 integron integrase; Region: integrase_gron; TIGR02249 1045855000400 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 1045855000401 Int/Topo IB signature motif; other site 1045855000402 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1045855000403 SnoaL-like domain; Region: SnoaL_3; pfam13474 1045855000404 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 1045855000405 CAAX protease self-immunity; Region: Abi; pfam02517 1045855000406 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1045855000407 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 1045855000408 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1045855000409 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1045855000410 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1045855000411 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1045855000412 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1045855000413 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1045855000414 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1045855000415 active site 1045855000416 metal binding site [ion binding]; metal-binding site 1045855000417 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1045855000418 amino acid transporter; Region: 2A0306; TIGR00909 1045855000419 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 1045855000420 putative metal binding site [ion binding]; other site 1045855000421 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1045855000422 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1045855000423 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1045855000424 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1045855000425 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045855000426 catalytic residues [active] 1045855000427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855000428 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1045855000429 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1045855000430 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1045855000431 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1045855000432 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1045855000433 NAD(P) binding site [chemical binding]; other site 1045855000434 shikimate binding site; other site 1045855000435 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1045855000436 dimer interface [polypeptide binding]; other site 1045855000437 allosteric magnesium binding site [ion binding]; other site 1045855000438 active site 1045855000439 aspartate-rich active site metal binding site; other site 1045855000440 Schiff base residues; other site 1045855000441 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1045855000442 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1045855000443 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045855000444 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1045855000445 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1045855000446 C-terminal domain interface [polypeptide binding]; other site 1045855000447 GSH binding site (G-site) [chemical binding]; other site 1045855000448 dimer interface [polypeptide binding]; other site 1045855000449 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1045855000450 N-terminal domain interface [polypeptide binding]; other site 1045855000451 putative dimer interface [polypeptide binding]; other site 1045855000452 active site 1045855000453 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1045855000454 cardiolipin synthase 2; Provisional; Region: PRK11263 1045855000455 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1045855000456 putative active site [active] 1045855000457 catalytic site [active] 1045855000458 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1045855000459 putative active site [active] 1045855000460 catalytic site [active] 1045855000461 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1045855000462 putative catalytic site [active] 1045855000463 putative metal binding site [ion binding]; other site 1045855000464 putative phosphate binding site [ion binding]; other site 1045855000465 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1045855000466 Part of AAA domain; Region: AAA_19; pfam13245 1045855000467 Family description; Region: UvrD_C_2; pfam13538 1045855000468 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1045855000469 Ligand Binding Site [chemical binding]; other site 1045855000470 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1045855000471 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1045855000472 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045855000473 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1045855000474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855000475 motif II; other site 1045855000476 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1045855000477 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1045855000478 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1045855000479 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1045855000480 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1045855000481 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045855000482 extended (e) SDRs; Region: SDR_e; cd08946 1045855000483 NAD(P) binding site [chemical binding]; other site 1045855000484 active site 1045855000485 substrate binding site [chemical binding]; other site 1045855000486 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1045855000487 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1045855000488 substrate binding site; other site 1045855000489 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1045855000490 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1045855000491 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1045855000492 CHASE3 domain; Region: CHASE3; pfam05227 1045855000493 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1045855000494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855000495 dimer interface [polypeptide binding]; other site 1045855000496 phosphorylation site [posttranslational modification] 1045855000497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855000498 ATP binding site [chemical binding]; other site 1045855000499 Mg2+ binding site [ion binding]; other site 1045855000500 G-X-G motif; other site 1045855000501 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855000502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855000503 active site 1045855000504 phosphorylation site [posttranslational modification] 1045855000505 intermolecular recognition site; other site 1045855000506 dimerization interface [polypeptide binding]; other site 1045855000507 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045855000508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855000509 active site 1045855000510 phosphorylation site [posttranslational modification] 1045855000511 intermolecular recognition site; other site 1045855000512 dimerization interface [polypeptide binding]; other site 1045855000513 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1045855000514 dimer interface [polypeptide binding]; other site 1045855000515 phosphorylation site [posttranslational modification] 1045855000516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855000517 ATP binding site [chemical binding]; other site 1045855000518 Mg2+ binding site [ion binding]; other site 1045855000519 G-X-G motif; other site 1045855000520 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045855000521 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1045855000522 nucleophilic elbow; other site 1045855000523 catalytic triad; other site 1045855000524 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1045855000525 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045855000526 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045855000527 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1045855000528 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1045855000529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855000530 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1045855000531 Walker A/P-loop; other site 1045855000532 ATP binding site [chemical binding]; other site 1045855000533 Q-loop/lid; other site 1045855000534 ABC transporter signature motif; other site 1045855000535 Walker B; other site 1045855000536 D-loop; other site 1045855000537 H-loop/switch region; other site 1045855000538 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1045855000539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855000540 dimer interface [polypeptide binding]; other site 1045855000541 conserved gate region; other site 1045855000542 ABC-ATPase subunit interface; other site 1045855000543 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1045855000544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045855000545 salt bridge; other site 1045855000546 non-specific DNA binding site [nucleotide binding]; other site 1045855000547 sequence-specific DNA binding site [nucleotide binding]; other site 1045855000548 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1045855000549 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045855000550 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855000551 catalytic residue [active] 1045855000552 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1045855000553 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1045855000554 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1045855000555 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1045855000556 threonine dehydratase; Reviewed; Region: PRK09224 1045855000557 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1045855000558 tetramer interface [polypeptide binding]; other site 1045855000559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855000560 catalytic residue [active] 1045855000561 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1045855000562 putative Ile/Val binding site [chemical binding]; other site 1045855000563 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1045855000564 putative Ile/Val binding site [chemical binding]; other site 1045855000565 Membrane transport protein; Region: Mem_trans; pfam03547 1045855000566 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1045855000567 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1045855000568 P-loop; other site 1045855000569 Magnesium ion binding site [ion binding]; other site 1045855000570 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1045855000571 catalytic core [active] 1045855000572 YceI-like domain; Region: YceI; cl01001 1045855000573 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1045855000574 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1045855000575 putative active site [active] 1045855000576 catalytic site [active] 1045855000577 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1045855000578 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1045855000579 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1045855000580 putative active site [active] 1045855000581 catalytic site [active] 1045855000582 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1045855000583 CoenzymeA binding site [chemical binding]; other site 1045855000584 subunit interaction site [polypeptide binding]; other site 1045855000585 PHB binding site; other site 1045855000586 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1045855000587 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1045855000588 putative acyl-acceptor binding pocket; other site 1045855000589 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045855000590 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1045855000591 substrate binding site [chemical binding]; other site 1045855000592 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1045855000593 glutamine synthetase; Provisional; Region: glnA; PRK09469 1045855000594 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1045855000595 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1045855000596 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1045855000597 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1045855000598 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1045855000599 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1045855000600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855000601 ATP binding site [chemical binding]; other site 1045855000602 Mg2+ binding site [ion binding]; other site 1045855000603 G-X-G motif; other site 1045855000604 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1045855000605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855000606 active site 1045855000607 phosphorylation site [posttranslational modification] 1045855000608 intermolecular recognition site; other site 1045855000609 dimerization interface [polypeptide binding]; other site 1045855000610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855000611 Walker A motif; other site 1045855000612 ATP binding site [chemical binding]; other site 1045855000613 Walker B motif; other site 1045855000614 arginine finger; other site 1045855000615 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1045855000616 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1045855000617 E-class dimer interface [polypeptide binding]; other site 1045855000618 P-class dimer interface [polypeptide binding]; other site 1045855000619 active site 1045855000620 Cu2+ binding site [ion binding]; other site 1045855000621 Zn2+ binding site [ion binding]; other site 1045855000622 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1045855000623 E-class dimer interface [polypeptide binding]; other site 1045855000624 P-class dimer interface [polypeptide binding]; other site 1045855000625 active site 1045855000626 Cu2+ binding site [ion binding]; other site 1045855000627 Zn2+ binding site [ion binding]; other site 1045855000628 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1045855000629 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1045855000630 dimer interface [polypeptide binding]; other site 1045855000631 active site 1045855000632 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 1045855000633 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1045855000634 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1045855000635 active site 1045855000636 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1045855000637 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1045855000638 active site residue [active] 1045855000639 preprotein translocase subunit SecB; Validated; Region: PRK05751 1045855000640 SecA binding site; other site 1045855000641 Preprotein binding site; other site 1045855000642 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1045855000643 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1045855000644 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1045855000645 KilA-N domain; Region: KilA-N; pfam04383 1045855000646 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1045855000647 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1045855000648 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1045855000649 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1045855000650 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1045855000651 putative active site [active] 1045855000652 catalytic site [active] 1045855000653 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1045855000654 putative active site [active] 1045855000655 catalytic site [active] 1045855000656 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1045855000657 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1045855000658 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1045855000659 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1045855000660 active site 1045855000661 catalytic residues [active] 1045855000662 metal binding site [ion binding]; metal-binding site 1045855000663 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1045855000664 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045855000665 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1045855000666 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1045855000667 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1045855000668 carboxyltransferase (CT) interaction site; other site 1045855000669 biotinylation site [posttranslational modification]; other site 1045855000670 enoyl-CoA hydratase; Provisional; Region: PRK05995 1045855000671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045855000672 substrate binding site [chemical binding]; other site 1045855000673 oxyanion hole (OAH) forming residues; other site 1045855000674 trimer interface [polypeptide binding]; other site 1045855000675 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1045855000676 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1045855000677 isovaleryl-CoA dehydrogenase; Region: PLN02519 1045855000678 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1045855000679 substrate binding site [chemical binding]; other site 1045855000680 FAD binding site [chemical binding]; other site 1045855000681 catalytic base [active] 1045855000682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045855000683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855000684 Domain of unknown function, B. Theta Gene description (DUF3876); Region: DUF3876; pfam12992 1045855000685 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1045855000686 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1045855000687 dimer interface [polypeptide binding]; other site 1045855000688 TPP-binding site [chemical binding]; other site 1045855000689 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1045855000690 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1045855000691 putative active site [active] 1045855000692 putative NTP binding site [chemical binding]; other site 1045855000693 putative nucleic acid binding site [nucleotide binding]; other site 1045855000694 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1045855000695 AAA domain; Region: AAA_22; pfam13401 1045855000696 AAA ATPase domain; Region: AAA_16; pfam13191 1045855000697 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1045855000698 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 1045855000699 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1045855000700 dimer interface [polypeptide binding]; other site 1045855000701 acyl-activating enzyme (AAE) consensus motif; other site 1045855000702 putative active site [active] 1045855000703 AMP binding site [chemical binding]; other site 1045855000704 putative CoA binding site [chemical binding]; other site 1045855000705 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1045855000706 GTP cyclohydrolase I; Provisional; Region: PLN03044 1045855000707 active site 1045855000708 Predicted membrane protein [Function unknown]; Region: COG1971 1045855000709 Domain of unknown function DUF; Region: DUF204; pfam02659 1045855000710 Domain of unknown function DUF; Region: DUF204; pfam02659 1045855000711 hypothetical protein; Provisional; Region: PRK04233 1045855000712 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1045855000713 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1045855000714 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1045855000715 putative NAD(P) binding site [chemical binding]; other site 1045855000716 putative substrate binding site [chemical binding]; other site 1045855000717 catalytic Zn binding site [ion binding]; other site 1045855000718 structural Zn binding site [ion binding]; other site 1045855000719 dimer interface [polypeptide binding]; other site 1045855000720 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1045855000721 active site 1045855000722 phosphate binding residues; other site 1045855000723 catalytic residues [active] 1045855000724 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1045855000725 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1045855000726 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 1045855000727 heme ligand [chemical binding]; other site 1045855000728 PAS fold; Region: PAS_2; pfam08446 1045855000729 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045855000730 GAF domain; Region: GAF; pfam01590 1045855000731 Phytochrome region; Region: PHY; pfam00360 1045855000732 PAS domain; Region: PAS_9; pfam13426 1045855000733 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1045855000734 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1045855000735 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1045855000736 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1045855000737 Benzoate membrane transport protein; Region: BenE; pfam03594 1045855000738 benzoate transporter; Region: benE; TIGR00843 1045855000739 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1045855000740 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045855000741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045855000742 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1045855000743 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1045855000744 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1045855000745 active site 1045855000746 dimer interface [polypeptide binding]; other site 1045855000747 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1045855000748 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1045855000749 active site 1045855000750 FMN binding site [chemical binding]; other site 1045855000751 substrate binding site [chemical binding]; other site 1045855000752 3Fe-4S cluster binding site [ion binding]; other site 1045855000753 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1045855000754 domain interface; other site 1045855000755 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1045855000756 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1045855000757 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1045855000758 active site 1045855000759 DNA binding site [nucleotide binding] 1045855000760 Int/Topo IB signature motif; other site 1045855000761 catalytic residues [active] 1045855000762 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1045855000763 active site 1045855000764 ribulose/triose binding site [chemical binding]; other site 1045855000765 phosphate binding site [ion binding]; other site 1045855000766 substrate (anthranilate) binding pocket [chemical binding]; other site 1045855000767 product (indole) binding pocket [chemical binding]; other site 1045855000768 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1045855000769 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1045855000770 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045855000771 ligand binding site [chemical binding]; other site 1045855000772 flexible hinge region; other site 1045855000773 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1045855000774 putative switch regulator; other site 1045855000775 non-specific DNA interactions [nucleotide binding]; other site 1045855000776 DNA binding site [nucleotide binding] 1045855000777 sequence specific DNA binding site [nucleotide binding]; other site 1045855000778 putative cAMP binding site [chemical binding]; other site 1045855000779 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1045855000780 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1045855000781 diiron binding motif [ion binding]; other site 1045855000782 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1045855000783 23S rRNA interface [nucleotide binding]; other site 1045855000784 L3 interface [polypeptide binding]; other site 1045855000785 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1045855000786 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1045855000787 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1045855000788 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1045855000789 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1045855000790 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1045855000791 C-terminal domain interface [polypeptide binding]; other site 1045855000792 GSH binding site (G-site) [chemical binding]; other site 1045855000793 putative dimer interface [polypeptide binding]; other site 1045855000794 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1045855000795 dimer interface [polypeptide binding]; other site 1045855000796 N-terminal domain interface [polypeptide binding]; other site 1045855000797 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1045855000798 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1045855000799 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1045855000800 ATP binding site [chemical binding]; other site 1045855000801 Walker B motif; other site 1045855000802 Protein of unknown function (DUF465); Region: DUF465; pfam04325 1045855000803 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1045855000804 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1045855000805 dimer interface [polypeptide binding]; other site 1045855000806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855000807 catalytic residue [active] 1045855000808 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1045855000809 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1045855000810 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1045855000811 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1045855000812 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1045855000813 homodimer interface [polypeptide binding]; other site 1045855000814 substrate-cofactor binding pocket; other site 1045855000815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855000816 catalytic residue [active] 1045855000817 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1045855000818 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1045855000819 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1045855000820 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1045855000821 Walker A/P-loop; other site 1045855000822 ATP binding site [chemical binding]; other site 1045855000823 Q-loop/lid; other site 1045855000824 ABC transporter signature motif; other site 1045855000825 Walker B; other site 1045855000826 D-loop; other site 1045855000827 H-loop/switch region; other site 1045855000828 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1045855000829 putative carbohydrate binding site [chemical binding]; other site 1045855000830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1045855000831 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1045855000832 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1045855000833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855000834 NAD(P) binding site [chemical binding]; other site 1045855000835 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045855000836 active site 1045855000837 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1045855000838 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1045855000839 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1045855000840 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1045855000841 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1045855000842 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1045855000843 AAA domain; Region: AAA_14; pfam13173 1045855000844 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1045855000845 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1045855000846 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1045855000847 Antitoxin ParD; Region: ParD; pfam09386 1045855000848 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1045855000849 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1045855000850 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1045855000851 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1045855000852 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1045855000853 Ligand binding site [chemical binding]; other site 1045855000854 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1045855000855 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1045855000856 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1045855000857 NAD binding site [chemical binding]; other site 1045855000858 substrate binding site [chemical binding]; other site 1045855000859 homodimer interface [polypeptide binding]; other site 1045855000860 active site 1045855000861 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1045855000862 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1045855000863 substrate binding site; other site 1045855000864 tetramer interface; other site 1045855000865 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1045855000866 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1045855000867 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1045855000868 NADP binding site [chemical binding]; other site 1045855000869 active site 1045855000870 putative substrate binding site [chemical binding]; other site 1045855000871 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1045855000872 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1045855000873 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1045855000874 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1045855000875 phosphomannomutase CpsG; Provisional; Region: PRK15414 1045855000876 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1045855000877 active site 1045855000878 substrate binding site [chemical binding]; other site 1045855000879 metal binding site [ion binding]; metal-binding site 1045855000880 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1045855000881 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1045855000882 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 1045855000883 putative ligand binding site [chemical binding]; other site 1045855000884 putative catalytic site [active] 1045855000885 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1045855000886 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1045855000887 Protein of unknown function (DUF330); Region: DUF330; cl01135 1045855000888 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1045855000889 mce related protein; Region: MCE; pfam02470 1045855000890 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1045855000891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855000892 Walker A/P-loop; other site 1045855000893 ATP binding site [chemical binding]; other site 1045855000894 Q-loop/lid; other site 1045855000895 ABC transporter signature motif; other site 1045855000896 Walker B; other site 1045855000897 D-loop; other site 1045855000898 H-loop/switch region; other site 1045855000899 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1045855000900 Permease; Region: Permease; pfam02405 1045855000901 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1045855000902 EamA-like transporter family; Region: EamA; pfam00892 1045855000903 EamA-like transporter family; Region: EamA; pfam00892 1045855000904 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1045855000905 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1045855000906 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1045855000907 H-NS histone family; Region: Histone_HNS; pfam00816 1045855000908 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1045855000909 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1045855000910 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1045855000911 dimer interface [polypeptide binding]; other site 1045855000912 motif 1; other site 1045855000913 active site 1045855000914 motif 2; other site 1045855000915 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1045855000916 putative deacylase active site [active] 1045855000917 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1045855000918 active site 1045855000919 motif 3; other site 1045855000920 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1045855000921 anticodon binding site; other site 1045855000922 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1045855000923 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1045855000924 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1045855000925 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1045855000926 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1045855000927 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045855000928 active site 1045855000929 HIGH motif; other site 1045855000930 nucleotide binding site [chemical binding]; other site 1045855000931 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1045855000932 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1045855000933 active site 1045855000934 KMSKS motif; other site 1045855000935 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1045855000936 tRNA binding surface [nucleotide binding]; other site 1045855000937 anticodon binding site; other site 1045855000938 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1045855000939 DNA polymerase III subunit chi; Validated; Region: PRK05728 1045855000940 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1045855000941 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1045855000942 interface (dimer of trimers) [polypeptide binding]; other site 1045855000943 Substrate-binding/catalytic site; other site 1045855000944 Zn-binding sites [ion binding]; other site 1045855000945 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1045855000946 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1045855000947 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1045855000948 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1045855000949 RDD family; Region: RDD; pfam06271 1045855000950 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1045855000951 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1045855000952 active site 1045855000953 Int/Topo IB signature motif; other site 1045855000954 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1045855000955 dimerization domain [polypeptide binding]; other site 1045855000956 dimer interface [polypeptide binding]; other site 1045855000957 catalytic residues [active] 1045855000958 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1045855000959 dimerization interface [polypeptide binding]; other site 1045855000960 ATP binding site [chemical binding]; other site 1045855000961 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1045855000962 dimerization interface [polypeptide binding]; other site 1045855000963 ATP binding site [chemical binding]; other site 1045855000964 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1045855000965 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 1045855000966 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1045855000967 putative active site [active] 1045855000968 catalytic triad [active] 1045855000969 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1045855000970 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1045855000971 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1045855000972 Walker A motif; other site 1045855000973 ATP binding site [chemical binding]; other site 1045855000974 Walker B motif; other site 1045855000975 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1045855000976 GIY-YIG motif/motif A; other site 1045855000977 putative active site [active] 1045855000978 putative metal binding site [ion binding]; other site 1045855000979 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1045855000980 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1045855000981 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1045855000982 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1045855000983 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1045855000984 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1045855000985 Type II transport protein GspH; Region: GspH; pfam12019 1045855000986 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1045855000987 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1045855000988 general secretion pathway protein J; Validated; Region: PRK08808 1045855000989 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1045855000990 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1045855000991 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 1045855000992 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1045855000993 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045855000994 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045855000995 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045855000996 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1045855000997 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1045855000998 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1045855000999 Probable Catalytic site; other site 1045855001000 metal-binding site 1045855001001 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1045855001002 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1045855001003 active site 1045855001004 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1045855001005 active site 1045855001006 catalytic residues [active] 1045855001007 metal binding site [ion binding]; metal-binding site 1045855001008 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1045855001009 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045855001010 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045855001011 ABC transporter; Region: ABC_tran_2; pfam12848 1045855001012 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045855001013 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1045855001014 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1045855001015 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1045855001016 dimer interface [polypeptide binding]; other site 1045855001017 active site 1045855001018 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1045855001019 folate binding site [chemical binding]; other site 1045855001020 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1045855001021 ATP cone domain; Region: ATP-cone; pfam03477 1045855001022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045855001023 Coenzyme A binding pocket [chemical binding]; other site 1045855001024 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1045855001025 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1045855001026 catalytic motif [active] 1045855001027 Zn binding site [ion binding]; other site 1045855001028 RibD C-terminal domain; Region: RibD_C; cl17279 1045855001029 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1045855001030 Lumazine binding domain; Region: Lum_binding; pfam00677 1045855001031 Lumazine binding domain; Region: Lum_binding; pfam00677 1045855001032 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1045855001033 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1045855001034 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1045855001035 dimerization interface [polypeptide binding]; other site 1045855001036 active site 1045855001037 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1045855001038 homopentamer interface [polypeptide binding]; other site 1045855001039 active site 1045855001040 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1045855001041 thiamine monophosphate kinase; Provisional; Region: PRK05731 1045855001042 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1045855001043 dimerization interface [polypeptide binding]; other site 1045855001044 ATP binding site [chemical binding]; other site 1045855001045 hypothetical protein; Reviewed; Region: PRK12497 1045855001046 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1045855001047 putative ligand binding site [chemical binding]; other site 1045855001048 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1045855001049 Predicted methyltransferases [General function prediction only]; Region: COG0313 1045855001050 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1045855001051 putative SAM binding site [chemical binding]; other site 1045855001052 putative homodimer interface [polypeptide binding]; other site 1045855001053 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1045855001054 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1045855001055 putative NAD(P) binding site [chemical binding]; other site 1045855001056 putative substrate binding site [chemical binding]; other site 1045855001057 catalytic Zn binding site [ion binding]; other site 1045855001058 structural Zn binding site [ion binding]; other site 1045855001059 NRDE protein; Region: NRDE; cl01315 1045855001060 cell division protein MraZ; Reviewed; Region: PRK00326 1045855001061 MraZ protein; Region: MraZ; pfam02381 1045855001062 MraZ protein; Region: MraZ; pfam02381 1045855001063 MraW methylase family; Region: Methyltransf_5; cl17771 1045855001064 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1045855001065 Cell division protein FtsL; Region: FtsL; pfam04999 1045855001066 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1045855001067 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1045855001068 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1045855001069 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1045855001070 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045855001071 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045855001072 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045855001073 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045855001074 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1045855001075 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045855001076 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1045855001077 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1045855001078 Mg++ binding site [ion binding]; other site 1045855001079 putative catalytic motif [active] 1045855001080 putative substrate binding site [chemical binding]; other site 1045855001081 cell division protein FtsW; Region: ftsW; TIGR02614 1045855001082 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1045855001083 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1045855001084 active site 1045855001085 homodimer interface [polypeptide binding]; other site 1045855001086 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1045855001087 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045855001088 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045855001089 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045855001090 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1045855001091 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1045855001092 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045855001093 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1045855001094 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1045855001095 Cell division protein FtsQ; Region: FtsQ; pfam03799 1045855001096 cell division protein FtsA; Region: ftsA; TIGR01174 1045855001097 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1045855001098 nucleotide binding site [chemical binding]; other site 1045855001099 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1045855001100 Cell division protein FtsA; Region: FtsA; pfam14450 1045855001101 cell division protein FtsZ; Validated; Region: PRK09330 1045855001102 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1045855001103 nucleotide binding site [chemical binding]; other site 1045855001104 SulA interaction site; other site 1045855001105 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1045855001106 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1045855001107 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1045855001108 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045855001109 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045855001110 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1045855001111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1045855001112 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1045855001113 SEC-C motif; Region: SEC-C; pfam02810 1045855001114 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1045855001115 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045855001116 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1045855001117 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045855001118 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1045855001119 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1045855001120 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1045855001121 Protein of unknown function, DUF484; Region: DUF484; cl17449 1045855001122 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1045855001123 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1045855001124 active site 1045855001125 Int/Topo IB signature motif; other site 1045855001126 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 1045855001127 active site 1045855001128 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1045855001129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855001130 Walker A motif; other site 1045855001131 ATP binding site [chemical binding]; other site 1045855001132 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1045855001133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855001134 ATP binding site [chemical binding]; other site 1045855001135 Walker A motif; other site 1045855001136 Walker B motif; other site 1045855001137 arginine finger; other site 1045855001138 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1045855001139 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1045855001140 nucleoside/Zn binding site; other site 1045855001141 dimer interface [polypeptide binding]; other site 1045855001142 catalytic motif [active] 1045855001143 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1045855001144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855001145 putative substrate translocation pore; other site 1045855001146 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1045855001147 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045855001148 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855001149 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045855001150 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1045855001151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855001152 S-adenosylmethionine binding site [chemical binding]; other site 1045855001153 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1045855001154 putative deacylase active site [active] 1045855001155 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 1045855001156 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 1045855001157 active site 1045855001158 Zn binding site [ion binding]; other site 1045855001159 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 1045855001160 HDOD domain; Region: HDOD; pfam08668 1045855001161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1045855001162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855001163 ATP binding site [chemical binding]; other site 1045855001164 Mg2+ binding site [ion binding]; other site 1045855001165 G-X-G motif; other site 1045855001166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855001167 metal binding site [ion binding]; metal-binding site 1045855001168 active site 1045855001169 I-site; other site 1045855001170 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045855001171 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1045855001172 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1045855001173 P-loop; other site 1045855001174 Magnesium ion binding site [ion binding]; other site 1045855001175 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1045855001176 Magnesium ion binding site [ion binding]; other site 1045855001177 flagellar motor protein MotD; Reviewed; Region: PRK09038 1045855001178 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1045855001179 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045855001180 ligand binding site [chemical binding]; other site 1045855001181 flagellar motor protein MotA; Validated; Region: PRK08124 1045855001182 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1045855001183 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1045855001184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045855001185 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1045855001186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045855001187 DNA binding residues [nucleotide binding] 1045855001188 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1045855001189 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045855001190 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1045855001191 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1045855001192 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045855001193 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1045855001194 FHIPEP family; Region: FHIPEP; pfam00771 1045855001195 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1045855001196 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1045855001197 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1045855001198 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1045855001199 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1045855001200 putative active site [active] 1045855001201 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1045855001202 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1045855001203 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1045855001204 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1045855001205 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1045855001206 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1045855001207 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1045855001208 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1045855001209 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1045855001210 Walker A motif; other site 1045855001211 ATP binding site [chemical binding]; other site 1045855001212 Walker B motif; other site 1045855001213 Flagellar assembly protein FliH; Region: FliH; pfam02108 1045855001214 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1045855001215 FliG C-terminal domain; Region: FliG_C; pfam01706 1045855001216 flagellar MS-ring protein; Reviewed; Region: fliF; PRK12800 1045855001217 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1045855001218 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1045855001219 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1045855001220 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1045855001221 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1045855001222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855001223 Walker A motif; other site 1045855001224 ATP binding site [chemical binding]; other site 1045855001225 Walker B motif; other site 1045855001226 arginine finger; other site 1045855001227 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1045855001228 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1045855001229 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1045855001230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045855001231 sequence-specific DNA binding site [nucleotide binding]; other site 1045855001232 salt bridge; other site 1045855001233 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045855001234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855001235 active site 1045855001236 phosphorylation site [posttranslational modification] 1045855001237 intermolecular recognition site; other site 1045855001238 dimerization interface [polypeptide binding]; other site 1045855001239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045855001240 DNA binding residues [nucleotide binding] 1045855001241 dimerization interface [polypeptide binding]; other site 1045855001242 Flagellar protein FliS; Region: FliS; cl00654 1045855001243 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 1045855001244 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1045855001245 flagellin; Reviewed; Region: PRK08869 1045855001246 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1045855001247 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1045855001248 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1045855001249 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1045855001250 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1045855001251 flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12714 1045855001252 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045855001253 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045855001254 flagellar rod assembly protein/muramidase FlgJ; Reviewed; Region: flgJ; PRK12711 1045855001255 Rod binding protein; Region: Rod-binding; cl01626 1045855001256 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1045855001257 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1045855001258 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1045855001259 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1045855001260 Flagellar L-ring protein; Region: FlgH; pfam02107 1045855001261 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1045855001262 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045855001263 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045855001264 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1045855001265 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045855001266 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045855001267 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1045855001268 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045855001269 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1045855001270 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045855001271 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1045855001272 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1045855001273 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12629 1045855001274 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045855001275 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045855001276 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12620 1045855001277 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1045855001278 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1045855001279 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1045855001280 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 1045855001281 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1045855001282 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1045855001283 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1045855001284 active site 1045855001285 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1045855001286 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1045855001287 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1045855001288 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045855001289 substrate binding site [chemical binding]; other site 1045855001290 ATP binding site [chemical binding]; other site 1045855001291 rod shape-determining protein MreB; Provisional; Region: PRK13927 1045855001292 MreB and similar proteins; Region: MreB_like; cd10225 1045855001293 nucleotide binding site [chemical binding]; other site 1045855001294 Mg binding site [ion binding]; other site 1045855001295 putative protofilament interaction site [polypeptide binding]; other site 1045855001296 RodZ interaction site [polypeptide binding]; other site 1045855001297 rod shape-determining protein MreC; Provisional; Region: PRK13922 1045855001298 rod shape-determining protein MreC; Region: MreC; pfam04085 1045855001299 rod shape-determining protein MreD; Region: MreD; cl01087 1045855001300 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1045855001301 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1045855001302 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1045855001303 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1045855001304 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1045855001305 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1045855001306 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045855001307 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045855001308 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1045855001309 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1045855001310 Sporulation related domain; Region: SPOR; pfam05036 1045855001311 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1045855001312 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1045855001313 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1045855001314 Protein of unknown function (DUF493); Region: DUF493; cl01102 1045855001315 lipoate-protein ligase B; Provisional; Region: PRK14342 1045855001316 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1045855001317 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1045855001318 metal binding triad; other site 1045855001319 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1045855001320 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1045855001321 metal binding triad; other site 1045855001322 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 1045855001323 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 1045855001324 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1045855001325 putative FMN binding site [chemical binding]; other site 1045855001326 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1045855001327 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1045855001328 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1045855001329 homodimer interface [polypeptide binding]; other site 1045855001330 substrate-cofactor binding pocket; other site 1045855001331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855001332 catalytic residue [active] 1045855001333 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1045855001334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855001335 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855001336 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855001337 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1045855001338 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1045855001339 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1045855001340 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1045855001341 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1045855001342 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1045855001343 metal binding site [ion binding]; metal-binding site 1045855001344 putative dimer interface [polypeptide binding]; other site 1045855001345 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045855001346 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045855001347 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045855001348 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045855001349 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045855001350 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045855001351 Amidohydrolase; Region: Amidohydro_4; pfam13147 1045855001352 active site 1045855001353 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1045855001354 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045855001355 active site 1045855001356 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 1045855001357 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855001358 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1045855001359 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855001360 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1045855001361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045855001362 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1045855001363 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1045855001364 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 1045855001365 homotrimer interaction site [polypeptide binding]; other site 1045855001366 putative active site [active] 1045855001367 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1045855001368 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045855001369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855001370 homodimer interface [polypeptide binding]; other site 1045855001371 catalytic residue [active] 1045855001372 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1045855001373 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045855001374 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045855001375 dimerization interface [polypeptide binding]; other site 1045855001376 DNA binding residues [nucleotide binding] 1045855001377 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1045855001378 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045855001379 inhibitor-cofactor binding pocket; inhibition site 1045855001380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855001381 catalytic residue [active] 1045855001382 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1045855001383 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855001384 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1045855001385 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1045855001386 active site 1045855001387 dimer interface [polypeptide binding]; other site 1045855001388 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1045855001389 thiamine phosphate binding site [chemical binding]; other site 1045855001390 active site 1045855001391 pyrophosphate binding site [ion binding]; other site 1045855001392 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1045855001393 Rubredoxin; Region: Rubredoxin; pfam00301 1045855001394 iron binding site [ion binding]; other site 1045855001395 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1045855001396 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1045855001397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855001398 active site 1045855001399 phosphorylation site [posttranslational modification] 1045855001400 intermolecular recognition site; other site 1045855001401 dimerization interface [polypeptide binding]; other site 1045855001402 LytTr DNA-binding domain; Region: LytTR; pfam04397 1045855001403 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1045855001404 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1045855001405 domain interfaces; other site 1045855001406 active site 1045855001407 Predicted transcriptional regulator [Transcription]; Region: COG2378 1045855001408 HTH domain; Region: HTH_11; pfam08279 1045855001409 WYL domain; Region: WYL; pfam13280 1045855001410 hypothetical protein; Provisional; Region: PRK08999 1045855001411 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1045855001412 active site 1045855001413 8-oxo-dGMP binding site [chemical binding]; other site 1045855001414 nudix motif; other site 1045855001415 metal binding site [ion binding]; metal-binding site 1045855001416 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1045855001417 active site 1045855001418 thiamine phosphate binding site [chemical binding]; other site 1045855001419 pyrophosphate binding site [ion binding]; other site 1045855001420 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1045855001421 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1045855001422 CoA-binding site [chemical binding]; other site 1045855001423 ATP-binding [chemical binding]; other site 1045855001424 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1045855001425 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1045855001426 active site 1045855001427 Isochorismatase family; Region: Isochorismatase; pfam00857 1045855001428 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1045855001429 catalytic triad [active] 1045855001430 conserved cis-peptide bond; other site 1045855001431 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1045855001432 pyruvate kinase; Validated; Region: PRK08187 1045855001433 active site 1045855001434 domain interfaces; other site 1045855001435 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1045855001436 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1045855001437 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1045855001438 dimer interface [polypeptide binding]; other site 1045855001439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855001440 catalytic residue [active] 1045855001441 siroheme synthase; Provisional; Region: cysG; PRK10637 1045855001442 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1045855001443 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1045855001444 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1045855001445 homodimer interface [polypeptide binding]; other site 1045855001446 active site 1045855001447 SAM binding site [chemical binding]; other site 1045855001448 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12680 1045855001449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855001450 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045855001451 dimerization interface [polypeptide binding]; other site 1045855001452 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1045855001453 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045855001454 N-terminal plug; other site 1045855001455 ligand-binding site [chemical binding]; other site 1045855001456 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1045855001457 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1045855001458 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045855001459 acyl-activating enzyme (AAE) consensus motif; other site 1045855001460 AMP binding site [chemical binding]; other site 1045855001461 active site 1045855001462 CoA binding site [chemical binding]; other site 1045855001463 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1045855001464 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1045855001465 Active Sites [active] 1045855001466 sulfite reductase subunit beta; Provisional; Region: PRK13504 1045855001467 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1045855001468 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1045855001469 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1045855001470 Flavodoxin; Region: Flavodoxin_1; pfam00258 1045855001471 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1045855001472 FAD binding pocket [chemical binding]; other site 1045855001473 conserved FAD binding motif [chemical binding]; other site 1045855001474 phosphate binding motif [ion binding]; other site 1045855001475 beta-alpha-beta structure motif; other site 1045855001476 NAD binding pocket [chemical binding]; other site 1045855001477 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1045855001478 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1045855001479 Active Sites [active] 1045855001480 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1045855001481 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1045855001482 CysD dimerization site [polypeptide binding]; other site 1045855001483 G1 box; other site 1045855001484 putative GEF interaction site [polypeptide binding]; other site 1045855001485 GTP/Mg2+ binding site [chemical binding]; other site 1045855001486 Switch I region; other site 1045855001487 G2 box; other site 1045855001488 G3 box; other site 1045855001489 Switch II region; other site 1045855001490 G4 box; other site 1045855001491 G5 box; other site 1045855001492 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1045855001493 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1045855001494 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1045855001495 ligand-binding site [chemical binding]; other site 1045855001496 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1045855001497 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1045855001498 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1045855001499 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1045855001500 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1045855001501 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1045855001502 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1045855001503 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1045855001504 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1045855001505 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1045855001506 iron-sulfur cluster [ion binding]; other site 1045855001507 [2Fe-2S] cluster binding site [ion binding]; other site 1045855001508 Uncharacterized conserved protein [Function unknown]; Region: COG3603 1045855001509 Family description; Region: ACT_7; pfam13840 1045855001510 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1045855001511 transmembrane helices; other site 1045855001512 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1045855001513 TrkA-C domain; Region: TrkA_C; pfam02080 1045855001514 TrkA-C domain; Region: TrkA_C; pfam02080 1045855001515 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1045855001516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855001517 S-adenosylmethionine binding site [chemical binding]; other site 1045855001518 integrase; Provisional; Region: PRK09692 1045855001519 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1045855001520 active site 1045855001521 Int/Topo IB signature motif; other site 1045855001522 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045855001523 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1045855001524 substrate binding pocket [chemical binding]; other site 1045855001525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045855001526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855001527 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1045855001528 dimerization interface [polypeptide binding]; other site 1045855001529 substrate binding pocket [chemical binding]; other site 1045855001530 Copper resistance protein D; Region: CopD; pfam05425 1045855001531 CopC domain; Region: CopC; pfam04234 1045855001532 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1045855001533 Domain of unknown function (DUF305); Region: DUF305; cl17794 1045855001534 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 1045855001535 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1045855001536 FAD binding pocket [chemical binding]; other site 1045855001537 FAD binding motif [chemical binding]; other site 1045855001538 phosphate binding motif [ion binding]; other site 1045855001539 beta-alpha-beta structure motif; other site 1045855001540 NAD binding pocket [chemical binding]; other site 1045855001541 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045855001542 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1045855001543 catalytic loop [active] 1045855001544 iron binding site [ion binding]; other site 1045855001545 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1045855001546 heme-binding residues [chemical binding]; other site 1045855001547 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1045855001548 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045855001549 metal-binding site [ion binding] 1045855001550 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1045855001551 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045855001552 metal-binding site [ion binding] 1045855001553 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045855001554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855001555 motif II; other site 1045855001556 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1045855001557 DNA binding residues [nucleotide binding] 1045855001558 dimer interface [polypeptide binding]; other site 1045855001559 copper binding site [ion binding]; other site 1045855001560 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1045855001561 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1045855001562 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1045855001563 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1045855001564 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1045855001565 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045855001566 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045855001567 active site 1045855001568 catalytic tetrad [active] 1045855001569 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1045855001570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855001571 NAD(P) binding site [chemical binding]; other site 1045855001572 active site 1045855001573 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045855001574 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045855001575 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045855001576 active site 1045855001577 catalytic tetrad [active] 1045855001578 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045855001579 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855001580 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1045855001581 putative effector binding pocket; other site 1045855001582 putative dimerization interface [polypeptide binding]; other site 1045855001583 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045855001584 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045855001585 active site 1045855001586 catalytic tetrad [active] 1045855001587 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1045855001588 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1045855001589 NAD(P) binding site [chemical binding]; other site 1045855001590 putative active site [active] 1045855001591 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1045855001592 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 1045855001593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045855001594 catalytic site [active] 1045855001595 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1045855001596 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1045855001597 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 1045855001598 thymidine phosphorylase; Provisional; Region: PRK04350 1045855001599 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1045855001600 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1045855001601 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1045855001602 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1045855001603 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045855001604 Beta-Casp domain; Region: Beta-Casp; pfam10996 1045855001605 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1045855001606 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 1045855001607 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1045855001608 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045855001609 active site 1045855001610 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1045855001611 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045855001612 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1045855001613 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1045855001614 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1045855001615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855001616 active site 1045855001617 phosphorylation site [posttranslational modification] 1045855001618 intermolecular recognition site; other site 1045855001619 dimerization interface [polypeptide binding]; other site 1045855001620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855001621 DNA binding site [nucleotide binding] 1045855001622 sensor kinase CusS; Provisional; Region: PRK09835 1045855001623 HAMP domain; Region: HAMP; pfam00672 1045855001624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855001625 dimer interface [polypeptide binding]; other site 1045855001626 phosphorylation site [posttranslational modification] 1045855001627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855001628 ATP binding site [chemical binding]; other site 1045855001629 Mg2+ binding site [ion binding]; other site 1045855001630 G-X-G motif; other site 1045855001631 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1045855001632 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1045855001633 NAD binding site [chemical binding]; other site 1045855001634 tetramer interface [polypeptide binding]; other site 1045855001635 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1045855001636 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1045855001637 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1045855001638 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1045855001639 DNA binding site [nucleotide binding] 1045855001640 dimer interface [polypeptide binding]; other site 1045855001641 active site 1045855001642 Int/Topo IB signature motif; other site 1045855001643 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1045855001644 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1045855001645 DNA binding residues [nucleotide binding] 1045855001646 dimer interface [polypeptide binding]; other site 1045855001647 putative metal binding site [ion binding]; other site 1045855001648 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1045855001649 putative metal dependent hydrolase; Provisional; Region: PRK11598 1045855001650 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1045855001651 Sulfatase; Region: Sulfatase; pfam00884 1045855001652 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1045855001653 Outer membrane efflux protein; Region: OEP; pfam02321 1045855001654 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1045855001655 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855001656 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1045855001657 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1045855001658 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045855001659 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1045855001660 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1045855001661 DNA binding site [nucleotide binding] 1045855001662 dimer interface [polypeptide binding]; other site 1045855001663 active site 1045855001664 Int/Topo IB signature motif; other site 1045855001665 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1045855001666 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1045855001667 DNA binding residues [nucleotide binding] 1045855001668 dimer interface [polypeptide binding]; other site 1045855001669 putative metal binding site [ion binding]; other site 1045855001670 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1045855001671 Outer membrane efflux protein; Region: OEP; pfam02321 1045855001672 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1045855001673 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855001674 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1045855001675 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1045855001676 Cation efflux family; Region: Cation_efflux; cl00316 1045855001677 arsenical pump membrane protein; Provisional; Region: PRK15445 1045855001678 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1045855001679 transmembrane helices; other site 1045855001680 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045855001681 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045855001682 ArsC family; Region: ArsC; pfam03960 1045855001683 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1045855001684 catalytic residues [active] 1045855001685 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1045855001686 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1045855001687 active site 1045855001688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045855001689 putative DNA binding site [nucleotide binding]; other site 1045855001690 dimerization interface [polypeptide binding]; other site 1045855001691 putative Zn2+ binding site [ion binding]; other site 1045855001692 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1045855001693 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045855001694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855001695 AAA domain; Region: AAA_21; pfam13304 1045855001696 Walker A/P-loop; other site 1045855001697 ATP binding site [chemical binding]; other site 1045855001698 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1045855001699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855001700 ABC transporter signature motif; other site 1045855001701 Walker B; other site 1045855001702 D-loop; other site 1045855001703 H-loop/switch region; other site 1045855001704 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1045855001705 putative active site [active] 1045855001706 putative metal-binding site [ion binding]; other site 1045855001707 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1045855001708 SEC-C motif; Region: SEC-C; pfam02810 1045855001709 Putative helicase; Region: TraI_2; pfam07514 1045855001710 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1045855001711 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1045855001712 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1045855001713 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1045855001714 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 1045855001715 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1045855001716 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1045855001717 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1045855001718 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1045855001719 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1045855001720 catalytic residues [active] 1045855001721 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1045855001722 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1045855001723 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1045855001724 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1045855001725 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1045855001726 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1045855001727 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1045855001728 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1045855001729 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 1045855001730 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1045855001731 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1045855001732 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1045855001733 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 1045855001734 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1045855001735 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1045855001736 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 1045855001737 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1045855001738 Active Sites [active] 1045855001739 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1045855001740 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1045855001741 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1045855001742 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1045855001743 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1045855001744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1045855001745 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1045855001746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855001747 nucleotide binding region [chemical binding]; other site 1045855001748 ATP-binding site [chemical binding]; other site 1045855001749 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1045855001750 S-adenosylmethionine binding site [chemical binding]; other site 1045855001751 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 1045855001752 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1045855001753 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1045855001754 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1045855001755 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 1045855001756 DNA topoisomerase III; Provisional; Region: PRK07726 1045855001757 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1045855001758 active site 1045855001759 putative interdomain interaction site [polypeptide binding]; other site 1045855001760 putative metal-binding site [ion binding]; other site 1045855001761 putative nucleotide binding site [chemical binding]; other site 1045855001762 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1045855001763 domain I; other site 1045855001764 DNA binding groove [nucleotide binding] 1045855001765 phosphate binding site [ion binding]; other site 1045855001766 domain II; other site 1045855001767 domain III; other site 1045855001768 nucleotide binding site [chemical binding]; other site 1045855001769 catalytic site [active] 1045855001770 domain IV; other site 1045855001771 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1045855001772 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1045855001773 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1045855001774 dimer interface [polypeptide binding]; other site 1045855001775 ssDNA binding site [nucleotide binding]; other site 1045855001776 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045855001777 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 1045855001778 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 1045855001779 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1045855001780 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1045855001781 ParB-like nuclease domain; Region: ParBc; pfam02195 1045855001782 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1045855001783 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045855001784 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1045855001785 Magnesium ion binding site [ion binding]; other site 1045855001786 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 1045855001787 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1045855001788 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1045855001789 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045855001790 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1045855001791 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855001792 Outer membrane efflux protein; Region: OEP; pfam02321 1045855001793 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1045855001794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855001795 active site 1045855001796 phosphorylation site [posttranslational modification] 1045855001797 intermolecular recognition site; other site 1045855001798 dimerization interface [polypeptide binding]; other site 1045855001799 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855001800 DNA binding site [nucleotide binding] 1045855001801 sensor protein QseC; Provisional; Region: PRK10337 1045855001802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855001803 ATP binding site [chemical binding]; other site 1045855001804 Mg2+ binding site [ion binding]; other site 1045855001805 G-X-G motif; other site 1045855001806 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1045855001807 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1045855001808 DNA binding residues [nucleotide binding] 1045855001809 dimer interface [polypeptide binding]; other site 1045855001810 copper binding site [ion binding]; other site 1045855001811 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045855001812 metal-binding site [ion binding] 1045855001813 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1045855001814 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045855001815 metal-binding site [ion binding] 1045855001816 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045855001817 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1045855001818 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045855001819 metal-binding site [ion binding] 1045855001820 RES domain; Region: RES; pfam08808 1045855001821 Formaldehyde dehydrogenases; Region: FDH_like; cd05278 1045855001822 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1045855001823 catalytic Zn binding site [ion binding]; other site 1045855001824 NAD(P) binding site [chemical binding]; other site 1045855001825 structural Zn binding site [ion binding]; other site 1045855001826 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1045855001827 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045855001828 catalytic loop [active] 1045855001829 iron binding site [ion binding]; other site 1045855001830 Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190 1045855001831 FAD binding pocket [chemical binding]; other site 1045855001832 FAD binding motif [chemical binding]; other site 1045855001833 phosphate binding motif [ion binding]; other site 1045855001834 beta-alpha-beta structure motif; other site 1045855001835 NAD binding pocket [chemical binding]; other site 1045855001836 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 1045855001837 dimerization interface [polypeptide binding]; other site 1045855001838 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1045855001839 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 1045855001840 [2Fe-2S] cluster binding site [ion binding]; other site 1045855001841 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 1045855001842 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 1045855001843 dimerization interface [polypeptide binding]; other site 1045855001844 putative path to active site cavity [active] 1045855001845 diiron center [ion binding]; other site 1045855001846 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1045855001847 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 1045855001848 tetramer interface [polypeptide binding]; other site 1045855001849 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1045855001850 active site 1045855001851 metal binding site [ion binding]; metal-binding site 1045855001852 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1045855001853 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045855001854 catalytic loop [active] 1045855001855 iron binding site [ion binding]; other site 1045855001856 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 1045855001857 FAD binding pocket [chemical binding]; other site 1045855001858 FAD binding motif [chemical binding]; other site 1045855001859 phosphate binding motif [ion binding]; other site 1045855001860 beta-alpha-beta structure motif; other site 1045855001861 NAD binding pocket [chemical binding]; other site 1045855001862 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 1045855001863 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 1045855001864 dimerization interface [polypeptide binding]; other site 1045855001865 putative path to active site cavity [active] 1045855001866 diiron center [ion binding]; other site 1045855001867 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1045855001868 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 1045855001869 dimerization interface [polypeptide binding]; other site 1045855001870 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 1045855001871 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1045855001872 V4R domain; Region: V4R; pfam02830 1045855001873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855001874 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1045855001875 Walker A motif; other site 1045855001876 ATP binding site [chemical binding]; other site 1045855001877 Walker B motif; other site 1045855001878 arginine finger; other site 1045855001879 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1045855001880 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1045855001881 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1045855001882 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045855001883 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045855001884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855001885 active site 1045855001886 phosphorylation site [posttranslational modification] 1045855001887 intermolecular recognition site; other site 1045855001888 dimerization interface [polypeptide binding]; other site 1045855001889 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855001890 DNA binding site [nucleotide binding] 1045855001891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855001892 HAMP domain; Region: HAMP; pfam00672 1045855001893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855001894 dimer interface [polypeptide binding]; other site 1045855001895 phosphorylation site [posttranslational modification] 1045855001896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855001897 ATP binding site [chemical binding]; other site 1045855001898 Mg2+ binding site [ion binding]; other site 1045855001899 G-X-G motif; other site 1045855001900 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1045855001901 FAD binding site [chemical binding]; other site 1045855001902 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855001903 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855001904 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1045855001905 putative active site [active] 1045855001906 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 1045855001907 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1045855001908 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1045855001909 FAD binding pocket [chemical binding]; other site 1045855001910 FAD binding motif [chemical binding]; other site 1045855001911 phosphate binding motif [ion binding]; other site 1045855001912 beta-alpha-beta structure motif; other site 1045855001913 NAD binding pocket [chemical binding]; other site 1045855001914 hypothetical protein; Provisional; Region: PRK09272 1045855001915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1045855001916 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1045855001917 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1045855001918 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1045855001919 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1045855001920 NAD(P) binding site [chemical binding]; other site 1045855001921 GAF domain; Region: GAF; pfam01590 1045855001922 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045855001923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855001924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855001925 ATP binding site [chemical binding]; other site 1045855001926 Mg2+ binding site [ion binding]; other site 1045855001927 G-X-G motif; other site 1045855001928 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1045855001929 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1045855001930 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1045855001931 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1045855001932 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855001933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855001934 metal binding site [ion binding]; metal-binding site 1045855001935 active site 1045855001936 I-site; other site 1045855001937 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1045855001938 putative metal binding site [ion binding]; other site 1045855001939 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1045855001940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045855001941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045855001942 DNA binding residues [nucleotide binding] 1045855001943 primosome assembly protein PriA; Validated; Region: PRK05580 1045855001944 RecX family; Region: RecX; cl00936 1045855001945 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855001946 ATP binding site [chemical binding]; other site 1045855001947 putative Mg++ binding site [ion binding]; other site 1045855001948 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1045855001949 multidrug efflux protein; Reviewed; Region: PRK01766 1045855001950 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1045855001951 cation binding site [ion binding]; other site 1045855001952 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1045855001953 tandem repeat interface [polypeptide binding]; other site 1045855001954 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1045855001955 oligomer interface [polypeptide binding]; other site 1045855001956 active site residues [active] 1045855001957 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1045855001958 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1045855001959 tandem repeat interface [polypeptide binding]; other site 1045855001960 oligomer interface [polypeptide binding]; other site 1045855001961 active site residues [active] 1045855001962 tropinone reductase; Provisional; Region: PRK09242 1045855001963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855001964 NAD(P) binding site [chemical binding]; other site 1045855001965 active site 1045855001966 Predicted membrane protein [Function unknown]; Region: COG3174 1045855001967 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1045855001968 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1045855001969 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1045855001970 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1045855001971 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1045855001972 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1045855001973 tetrameric interface [polypeptide binding]; other site 1045855001974 NAD binding site [chemical binding]; other site 1045855001975 catalytic residues [active] 1045855001976 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1045855001977 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1045855001978 active site 1045855001979 enoyl-CoA hydratase; Provisional; Region: PRK09076 1045855001980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045855001981 substrate binding site [chemical binding]; other site 1045855001982 oxyanion hole (OAH) forming residues; other site 1045855001983 trimer interface [polypeptide binding]; other site 1045855001984 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1045855001985 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1045855001986 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045855001987 substrate binding site [chemical binding]; other site 1045855001988 oxyanion hole (OAH) forming residues; other site 1045855001989 trimer interface [polypeptide binding]; other site 1045855001990 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1045855001991 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1045855001992 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1045855001993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1045855001994 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1045855001995 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1045855001996 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1045855001997 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1045855001998 DNA topoisomerase I; Provisional; Region: PRK08780 1045855001999 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1045855002000 active site 1045855002001 interdomain interaction site; other site 1045855002002 putative metal-binding site [ion binding]; other site 1045855002003 nucleotide binding site [chemical binding]; other site 1045855002004 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1045855002005 domain I; other site 1045855002006 DNA binding groove [nucleotide binding] 1045855002007 phosphate binding site [ion binding]; other site 1045855002008 domain II; other site 1045855002009 domain III; other site 1045855002010 nucleotide binding site [chemical binding]; other site 1045855002011 catalytic site [active] 1045855002012 domain IV; other site 1045855002013 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1045855002014 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1045855002015 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1045855002016 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1045855002017 YcfA-like protein; Region: YcfA; pfam07927 1045855002018 Protein of unknown function (DUF494); Region: DUF494; cl01103 1045855002019 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1045855002020 DNA protecting protein DprA; Region: dprA; TIGR00732 1045855002021 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045855002022 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1045855002023 active site 1045855002024 catalytic residues [active] 1045855002025 metal binding site [ion binding]; metal-binding site 1045855002026 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1045855002027 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1045855002028 putative active site [active] 1045855002029 substrate binding site [chemical binding]; other site 1045855002030 putative cosubstrate binding site; other site 1045855002031 catalytic site [active] 1045855002032 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1045855002033 substrate binding site [chemical binding]; other site 1045855002034 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1045855002035 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1045855002036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855002037 S-adenosylmethionine binding site [chemical binding]; other site 1045855002038 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1045855002039 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1045855002040 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1045855002041 O-Antigen ligase; Region: Wzy_C; pfam04932 1045855002042 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1045855002043 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1045855002044 putative metal binding site; other site 1045855002045 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1045855002046 Bacterial PH domain; Region: DUF304; cl01348 1045855002047 Predicted membrane protein [Function unknown]; Region: COG3428 1045855002048 Bacterial PH domain; Region: DUF304; pfam03703 1045855002049 Bacterial PH domain; Region: DUF304; pfam03703 1045855002050 Bacterial PH domain; Region: DUF304; pfam03703 1045855002051 GTP cyclohydrolase; Provisional; Region: PRK08815 1045855002052 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1045855002053 dimerization interface [polypeptide binding]; other site 1045855002054 active site 1045855002055 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1045855002056 putative active site [active] 1045855002057 dimerization interface [polypeptide binding]; other site 1045855002058 putative tRNAtyr binding site [nucleotide binding]; other site 1045855002059 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1045855002060 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1045855002061 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1045855002062 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1045855002063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045855002064 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1045855002065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045855002066 DNA binding residues [nucleotide binding] 1045855002067 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1045855002068 Ligand binding site; other site 1045855002069 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1045855002070 DXD motif; other site 1045855002071 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1045855002072 H-NS histone family; Region: Histone_HNS; pfam00816 1045855002073 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1045855002074 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1045855002075 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1045855002076 homotetramer interface [polypeptide binding]; other site 1045855002077 ligand binding site [chemical binding]; other site 1045855002078 catalytic site [active] 1045855002079 NAD binding site [chemical binding]; other site 1045855002080 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1045855002081 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1045855002082 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1045855002083 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1045855002084 putative dimer interface [polypeptide binding]; other site 1045855002085 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045855002086 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045855002087 active site 1045855002088 catalytic tetrad [active] 1045855002089 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1045855002090 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1045855002091 ABC transporter ATPase component; Reviewed; Region: PRK11147 1045855002092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855002093 Walker A/P-loop; other site 1045855002094 ATP binding site [chemical binding]; other site 1045855002095 Q-loop/lid; other site 1045855002096 ABC transporter signature motif; other site 1045855002097 Walker B; other site 1045855002098 D-loop; other site 1045855002099 H-loop/switch region; other site 1045855002100 ABC transporter; Region: ABC_tran_2; pfam12848 1045855002101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045855002102 putative MFS family transporter protein; Provisional; Region: PRK03633 1045855002103 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1045855002104 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 1045855002105 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1045855002106 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1045855002107 dimer interface [polypeptide binding]; other site 1045855002108 anticodon binding site; other site 1045855002109 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1045855002110 homodimer interface [polypeptide binding]; other site 1045855002111 motif 1; other site 1045855002112 active site 1045855002113 motif 2; other site 1045855002114 GAD domain; Region: GAD; pfam02938 1045855002115 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1045855002116 active site 1045855002117 motif 3; other site 1045855002118 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1045855002119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045855002120 Coenzyme A binding pocket [chemical binding]; other site 1045855002121 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1045855002122 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1045855002123 hypothetical protein; Validated; Region: PRK00110 1045855002124 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1045855002125 active site 1045855002126 putative DNA-binding cleft [nucleotide binding]; other site 1045855002127 dimer interface [polypeptide binding]; other site 1045855002128 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1045855002129 RuvA N terminal domain; Region: RuvA_N; pfam01330 1045855002130 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1045855002131 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1045855002132 potassium uptake protein; Region: kup; TIGR00794 1045855002133 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1045855002134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855002135 Walker A motif; other site 1045855002136 ATP binding site [chemical binding]; other site 1045855002137 Walker B motif; other site 1045855002138 arginine finger; other site 1045855002139 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1045855002140 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1045855002141 active site 1045855002142 TolQ protein; Region: tolQ; TIGR02796 1045855002143 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1045855002144 TolR protein; Region: tolR; TIGR02801 1045855002145 TolA protein; Region: tolA_full; TIGR02794 1045855002146 TonB C terminal; Region: TonB_2; pfam13103 1045855002147 translocation protein TolB; Provisional; Region: tolB; PRK04922 1045855002148 TolB amino-terminal domain; Region: TolB_N; pfam04052 1045855002149 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045855002150 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045855002151 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045855002152 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1045855002153 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045855002154 ligand binding site [chemical binding]; other site 1045855002155 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1045855002156 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1045855002157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045855002158 FeS/SAM binding site; other site 1045855002159 C2 domain; Region: C2; cl14603 1045855002160 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1045855002161 Ligand Binding Site [chemical binding]; other site 1045855002162 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1045855002163 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1045855002164 dimerization interface [polypeptide binding]; other site 1045855002165 domain crossover interface; other site 1045855002166 redox-dependent activation switch; other site 1045855002167 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1045855002168 Transglycosylase; Region: Transgly; cl17702 1045855002169 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1045855002170 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1045855002171 Ligand binding site; other site 1045855002172 Putative Catalytic site; other site 1045855002173 DXD motif; other site 1045855002174 FOG: CBS domain [General function prediction only]; Region: COG0517 1045855002175 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1045855002176 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1045855002177 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1045855002178 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1045855002179 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1045855002180 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1045855002181 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1045855002182 G1 box; other site 1045855002183 putative GEF interaction site [polypeptide binding]; other site 1045855002184 GTP/Mg2+ binding site [chemical binding]; other site 1045855002185 Switch I region; other site 1045855002186 G2 box; other site 1045855002187 G3 box; other site 1045855002188 Switch II region; other site 1045855002189 G4 box; other site 1045855002190 G5 box; other site 1045855002191 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1045855002192 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1045855002193 Transglycosylase; Region: Transgly; pfam00912 1045855002194 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1045855002195 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1045855002196 Competence protein A; Region: Competence_A; pfam11104 1045855002197 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1045855002198 nucleotide binding site [chemical binding]; other site 1045855002199 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1045855002200 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1045855002201 Pilus assembly protein, PilO; Region: PilO; cl01234 1045855002202 Pilus assembly protein, PilP; Region: PilP; pfam04351 1045855002203 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1045855002204 Secretin and TonB N terminus short domain; Region: STN; pfam07660 1045855002205 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045855002206 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1045855002207 MoxR-like ATPases [General function prediction only]; Region: COG0714 1045855002208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855002209 Walker A motif; other site 1045855002210 ATP binding site [chemical binding]; other site 1045855002211 Walker B motif; other site 1045855002212 arginine finger; other site 1045855002213 Protein of unknown function DUF58; Region: DUF58; pfam01882 1045855002214 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1045855002215 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1045855002216 metal ion-dependent adhesion site (MIDAS); other site 1045855002217 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1045855002218 metal ion-dependent adhesion site (MIDAS); other site 1045855002219 Oxygen tolerance; Region: BatD; pfam13584 1045855002220 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045855002221 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1045855002222 transketolase; Reviewed; Region: PRK12753 1045855002223 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1045855002224 TPP-binding site [chemical binding]; other site 1045855002225 dimer interface [polypeptide binding]; other site 1045855002226 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1045855002227 PYR/PP interface [polypeptide binding]; other site 1045855002228 dimer interface [polypeptide binding]; other site 1045855002229 TPP binding site [chemical binding]; other site 1045855002230 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1045855002231 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1045855002232 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1045855002233 Probable Catalytic site; other site 1045855002234 metal-binding site 1045855002235 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1045855002236 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1045855002237 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1045855002238 Transglycosylase; Region: Transgly; pfam00912 1045855002239 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1045855002240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855002241 binding surface 1045855002242 TPR repeat; Region: TPR_11; pfam13414 1045855002243 TPR motif; other site 1045855002244 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1045855002245 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1045855002246 ATP binding site [chemical binding]; other site 1045855002247 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1045855002248 NAD synthetase; Provisional; Region: PRK13981 1045855002249 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1045855002250 multimer interface [polypeptide binding]; other site 1045855002251 active site 1045855002252 catalytic triad [active] 1045855002253 protein interface 1 [polypeptide binding]; other site 1045855002254 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1045855002255 homodimer interface [polypeptide binding]; other site 1045855002256 NAD binding pocket [chemical binding]; other site 1045855002257 ATP binding pocket [chemical binding]; other site 1045855002258 Mg binding site [ion binding]; other site 1045855002259 active-site loop [active] 1045855002260 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1045855002261 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1045855002262 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045855002263 RNA binding surface [nucleotide binding]; other site 1045855002264 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1045855002265 active site 1045855002266 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1045855002267 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1045855002268 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1045855002269 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 1045855002270 glutathione s-transferase; Provisional; Region: PTZ00057 1045855002271 GSH binding site (G-site) [chemical binding]; other site 1045855002272 C-terminal domain interface [polypeptide binding]; other site 1045855002273 dimer interface [polypeptide binding]; other site 1045855002274 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 1045855002275 dimer interface [polypeptide binding]; other site 1045855002276 N-terminal domain interface [polypeptide binding]; other site 1045855002277 substrate binding pocket (H-site) [chemical binding]; other site 1045855002278 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1045855002279 GIY-YIG motif/motif A; other site 1045855002280 putative active site [active] 1045855002281 putative metal binding site [ion binding]; other site 1045855002282 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1045855002283 Clp amino terminal domain; Region: Clp_N; pfam02861 1045855002284 Clp amino terminal domain; Region: Clp_N; pfam02861 1045855002285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855002286 Walker A motif; other site 1045855002287 ATP binding site [chemical binding]; other site 1045855002288 Walker B motif; other site 1045855002289 arginine finger; other site 1045855002290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855002291 Walker A motif; other site 1045855002292 ATP binding site [chemical binding]; other site 1045855002293 Walker B motif; other site 1045855002294 arginine finger; other site 1045855002295 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1045855002296 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1045855002297 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1045855002298 homodimer interface [polypeptide binding]; other site 1045855002299 substrate-cofactor binding pocket; other site 1045855002300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855002301 catalytic residue [active] 1045855002302 putative cation:proton antiport protein; Provisional; Region: PRK10669 1045855002303 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1045855002304 TrkA-N domain; Region: TrkA_N; pfam02254 1045855002305 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 1045855002306 catalytic triad [active] 1045855002307 putative active site [active] 1045855002308 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045855002309 N-terminal plug; other site 1045855002310 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855002311 ligand-binding site [chemical binding]; other site 1045855002312 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1045855002313 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045855002314 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045855002315 ABC transporter; Region: ABC_tran_2; pfam12848 1045855002316 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045855002317 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1045855002318 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1045855002319 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1045855002320 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1045855002321 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1045855002322 putative acyl-acceptor binding pocket; other site 1045855002323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1045855002324 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1045855002325 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1045855002326 putative active site [active] 1045855002327 putative metal binding site [ion binding]; other site 1045855002328 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1045855002329 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1045855002330 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1045855002331 FMN binding site [chemical binding]; other site 1045855002332 active site 1045855002333 catalytic residues [active] 1045855002334 substrate binding site [chemical binding]; other site 1045855002335 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1045855002336 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1045855002337 putative metal binding site [ion binding]; other site 1045855002338 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1045855002339 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1045855002340 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1045855002341 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045855002342 substrate binding site [chemical binding]; other site 1045855002343 dimer interface [polypeptide binding]; other site 1045855002344 ATP binding site [chemical binding]; other site 1045855002345 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1045855002346 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1045855002347 Nucleoside recognition; Region: Gate; pfam07670 1045855002348 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1045855002349 Hemin uptake protein hemP; Region: hemP; pfam10636 1045855002350 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1045855002351 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1045855002352 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1045855002353 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1045855002354 POPLD (NUC188) domain; Region: POPLD; pfam08170 1045855002355 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1045855002356 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1045855002357 lipoyl attachment site [posttranslational modification]; other site 1045855002358 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1045855002359 Beta-lactamase; Region: Beta-lactamase; pfam00144 1045855002360 EamA-like transporter family; Region: EamA; pfam00892 1045855002361 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1045855002362 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1045855002363 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1045855002364 active site 1045855002365 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1045855002366 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1045855002367 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045855002368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045855002369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855002370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855002371 TPR motif; other site 1045855002372 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1045855002373 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1045855002374 oligomeric interface; other site 1045855002375 putative active site [active] 1045855002376 homodimer interface [polypeptide binding]; other site 1045855002377 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1045855002378 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1045855002379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855002380 active site 1045855002381 phosphorylation site [posttranslational modification] 1045855002382 intermolecular recognition site; other site 1045855002383 dimerization interface [polypeptide binding]; other site 1045855002384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855002385 Walker A motif; other site 1045855002386 ATP binding site [chemical binding]; other site 1045855002387 Walker B motif; other site 1045855002388 arginine finger; other site 1045855002389 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1045855002390 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1045855002391 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1045855002392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855002393 dimer interface [polypeptide binding]; other site 1045855002394 phosphorylation site [posttranslational modification] 1045855002395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855002396 ATP binding site [chemical binding]; other site 1045855002397 Mg2+ binding site [ion binding]; other site 1045855002398 G-X-G motif; other site 1045855002399 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1045855002400 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1045855002401 CoA-ligase; Region: Ligase_CoA; pfam00549 1045855002402 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1045855002403 CoA binding domain; Region: CoA_binding; smart00881 1045855002404 CoA-ligase; Region: Ligase_CoA; pfam00549 1045855002405 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1045855002406 Glycoprotease family; Region: Peptidase_M22; pfam00814 1045855002407 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1045855002408 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1045855002409 glutathione synthetase; Provisional; Region: PRK05246 1045855002410 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1045855002411 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1045855002412 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855002413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855002414 active site 1045855002415 phosphorylation site [posttranslational modification] 1045855002416 intermolecular recognition site; other site 1045855002417 dimerization interface [polypeptide binding]; other site 1045855002418 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1045855002419 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1045855002420 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045855002421 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045855002422 dimer interface [polypeptide binding]; other site 1045855002423 putative CheW interface [polypeptide binding]; other site 1045855002424 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1045855002425 putative binding surface; other site 1045855002426 active site 1045855002427 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1045855002428 putative binding surface; other site 1045855002429 active site 1045855002430 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1045855002431 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1045855002432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855002433 ATP binding site [chemical binding]; other site 1045855002434 G-X-G motif; other site 1045855002435 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1045855002436 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855002437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855002438 active site 1045855002439 phosphorylation site [posttranslational modification] 1045855002440 intermolecular recognition site; other site 1045855002441 dimerization interface [polypeptide binding]; other site 1045855002442 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1045855002443 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1045855002444 EF-hand domain pair; Region: EF_hand_5; pfam13499 1045855002445 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1045855002446 Ca2+ binding site [ion binding]; other site 1045855002447 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1045855002448 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1045855002449 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1045855002450 dimer interface [polypeptide binding]; other site 1045855002451 ADP-ribose binding site [chemical binding]; other site 1045855002452 active site 1045855002453 nudix motif; other site 1045855002454 metal binding site [ion binding]; metal-binding site 1045855002455 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1045855002456 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1045855002457 active site 1045855002458 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1045855002459 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1045855002460 homodimer interface [polypeptide binding]; other site 1045855002461 metal binding site [ion binding]; metal-binding site 1045855002462 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1045855002463 homodimer interface [polypeptide binding]; other site 1045855002464 active site 1045855002465 putative chemical substrate binding site [chemical binding]; other site 1045855002466 metal binding site [ion binding]; metal-binding site 1045855002467 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1045855002468 Protein of unknown function, DUF486; Region: DUF486; cl01236 1045855002469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045855002470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855002471 active site 1045855002472 phosphorylation site [posttranslational modification] 1045855002473 intermolecular recognition site; other site 1045855002474 dimerization interface [polypeptide binding]; other site 1045855002475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855002476 DNA binding site [nucleotide binding] 1045855002477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855002478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855002479 dimer interface [polypeptide binding]; other site 1045855002480 phosphorylation site [posttranslational modification] 1045855002481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855002482 ATP binding site [chemical binding]; other site 1045855002483 Mg2+ binding site [ion binding]; other site 1045855002484 G-X-G motif; other site 1045855002485 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1045855002486 catalytic nucleophile [active] 1045855002487 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 1045855002488 active site 1045855002489 catalytic triad [active] 1045855002490 oxyanion hole [active] 1045855002491 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1045855002492 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1045855002493 LemA family; Region: LemA; pfam04011 1045855002494 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1045855002495 Repair protein; Region: Repair_PSII; pfam04536 1045855002496 Repair protein; Region: Repair_PSII; cl01535 1045855002497 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1045855002498 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1045855002499 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1045855002500 dimerization interface [polypeptide binding]; other site 1045855002501 active site 1045855002502 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1045855002503 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1045855002504 folate binding site [chemical binding]; other site 1045855002505 NADP+ binding site [chemical binding]; other site 1045855002506 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1045855002507 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1045855002508 active site 1045855002509 metal binding site [ion binding]; metal-binding site 1045855002510 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1045855002511 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1045855002512 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1045855002513 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1045855002514 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1045855002515 SurA N-terminal domain; Region: SurA_N; pfam09312 1045855002516 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1045855002517 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1045855002518 organic solvent tolerance protein; Provisional; Region: PRK04423 1045855002519 OstA-like protein; Region: OstA; cl00844 1045855002520 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1045855002521 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1045855002522 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1045855002523 putative active site [active] 1045855002524 Zn binding site [ion binding]; other site 1045855002525 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1045855002526 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1045855002527 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1045855002528 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Validated; Region: PRK08773 1045855002529 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1045855002530 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1045855002531 Protein of unknown function (DUF497); Region: DUF497; cl01108 1045855002532 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1045855002533 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1045855002534 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1045855002535 nucleoside/Zn binding site; other site 1045855002536 dimer interface [polypeptide binding]; other site 1045855002537 catalytic motif [active] 1045855002538 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1045855002539 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045855002540 active site 1045855002541 HIGH motif; other site 1045855002542 nucleotide binding site [chemical binding]; other site 1045855002543 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045855002544 active site 1045855002545 KMSKS motif; other site 1045855002546 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1045855002547 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1045855002548 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1045855002549 hypothetical protein; Validated; Region: PRK00228 1045855002550 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1045855002551 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1045855002552 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1045855002553 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1045855002554 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1045855002555 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1045855002556 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1045855002557 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855002558 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855002559 metal binding site [ion binding]; metal-binding site 1045855002560 active site 1045855002561 I-site; other site 1045855002562 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1045855002563 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1045855002564 DXD motif; other site 1045855002565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1045855002566 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1045855002567 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1045855002568 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1045855002569 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1045855002570 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1045855002571 catalytic triad [active] 1045855002572 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1045855002573 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1045855002574 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1045855002575 MgtE intracellular N domain; Region: MgtE_N; smart00924 1045855002576 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1045855002577 Divalent cation transporter; Region: MgtE; cl00786 1045855002578 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1045855002579 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1045855002580 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1045855002581 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1045855002582 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1045855002583 dimerization domain swap beta strand [polypeptide binding]; other site 1045855002584 regulatory protein interface [polypeptide binding]; other site 1045855002585 active site 1045855002586 regulatory phosphorylation site [posttranslational modification]; other site 1045855002587 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1045855002588 active pocket/dimerization site; other site 1045855002589 active site 1045855002590 phosphorylation site [posttranslational modification] 1045855002591 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1045855002592 AAA domain; Region: AAA_33; pfam13671 1045855002593 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1045855002594 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1045855002595 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1045855002596 Hpr binding site; other site 1045855002597 active site 1045855002598 homohexamer subunit interaction site [polypeptide binding]; other site 1045855002599 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1045855002600 30S subunit binding site; other site 1045855002601 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1045855002602 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1045855002603 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1045855002604 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1045855002605 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1045855002606 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1045855002607 Walker A/P-loop; other site 1045855002608 ATP binding site [chemical binding]; other site 1045855002609 Q-loop/lid; other site 1045855002610 ABC transporter signature motif; other site 1045855002611 Walker B; other site 1045855002612 D-loop; other site 1045855002613 H-loop/switch region; other site 1045855002614 OstA-like protein; Region: OstA; cl00844 1045855002615 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1045855002616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1045855002617 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1045855002618 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1045855002619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855002620 active site 1045855002621 motif I; other site 1045855002622 motif II; other site 1045855002623 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1045855002624 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1045855002625 putative active site [active] 1045855002626 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1045855002627 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1045855002628 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1045855002629 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1045855002630 hinge; other site 1045855002631 active site 1045855002632 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1045855002633 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1045855002634 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1045855002635 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1045855002636 active site 1045855002637 substrate binding site [chemical binding]; other site 1045855002638 cosubstrate binding site; other site 1045855002639 catalytic site [active] 1045855002640 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1045855002641 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1045855002642 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1045855002643 dimerization interface [polypeptide binding]; other site 1045855002644 putative ATP binding site [chemical binding]; other site 1045855002645 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1045855002646 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1045855002647 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1045855002648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1045855002649 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1045855002650 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1045855002651 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1045855002652 Substrate binding site; other site 1045855002653 metal-binding site 1045855002654 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1045855002655 Phosphotransferase enzyme family; Region: APH; pfam01636 1045855002656 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1045855002657 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1045855002658 Substrate binding site; other site 1045855002659 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1045855002660 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1045855002661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855002662 putative substrate translocation pore; other site 1045855002663 Predicted membrane protein [Function unknown]; Region: COG2261 1045855002664 hypothetical protein; Provisional; Region: PRK07907 1045855002665 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 1045855002666 metal binding site [ion binding]; metal-binding site 1045855002667 putative dimer interface [polypeptide binding]; other site 1045855002668 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1045855002669 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1045855002670 Flavodoxin; Region: Flavodoxin_1; pfam00258 1045855002671 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1045855002672 FAD binding pocket [chemical binding]; other site 1045855002673 FAD binding motif [chemical binding]; other site 1045855002674 catalytic residues [active] 1045855002675 NAD binding pocket [chemical binding]; other site 1045855002676 phosphate binding motif [ion binding]; other site 1045855002677 beta-alpha-beta structure motif; other site 1045855002678 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1045855002679 ApbE family; Region: ApbE; pfam02424 1045855002680 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1045855002681 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856 1045855002682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 1045855002683 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1045855002684 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1045855002685 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 1045855002686 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045855002687 N-terminal plug; other site 1045855002688 ligand-binding site [chemical binding]; other site 1045855002689 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1045855002690 [2Fe-2S] cluster binding site [ion binding]; other site 1045855002691 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1045855002692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045855002693 Coenzyme A binding pocket [chemical binding]; other site 1045855002694 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1045855002695 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1045855002696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855002697 catalytic residue [active] 1045855002698 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1045855002699 FeS assembly protein SufD; Region: sufD; TIGR01981 1045855002700 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1045855002701 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1045855002702 Walker A/P-loop; other site 1045855002703 ATP binding site [chemical binding]; other site 1045855002704 Q-loop/lid; other site 1045855002705 ABC transporter signature motif; other site 1045855002706 Walker B; other site 1045855002707 D-loop; other site 1045855002708 H-loop/switch region; other site 1045855002709 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1045855002710 putative ABC transporter; Region: ycf24; CHL00085 1045855002711 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1045855002712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045855002713 putative Zn2+ binding site [ion binding]; other site 1045855002714 putative DNA binding site [nucleotide binding]; other site 1045855002715 dimerization interface [polypeptide binding]; other site 1045855002716 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 1045855002717 Proteins containing SET domain [General function prediction only]; Region: COG2940 1045855002718 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1045855002719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855002720 NAD(P) binding site [chemical binding]; other site 1045855002721 active site 1045855002722 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1045855002723 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1045855002724 proposed catalytic triad [active] 1045855002725 conserved cys residue [active] 1045855002726 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 1045855002727 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 1045855002728 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045855002729 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045855002730 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 1045855002731 IHF dimer interface [polypeptide binding]; other site 1045855002732 IHF - DNA interface [nucleotide binding]; other site 1045855002733 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1045855002734 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1045855002735 Bacterial transcriptional regulator; Region: IclR; pfam01614 1045855002736 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1045855002737 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1045855002738 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 1045855002739 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1045855002740 nucleotide binding site [chemical binding]; other site 1045855002741 substrate binding site [chemical binding]; other site 1045855002742 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 1045855002743 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1045855002744 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1045855002745 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045855002746 catalytic residue [active] 1045855002747 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 1045855002748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045855002749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045855002750 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1045855002751 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1045855002752 active site 1045855002753 dimerization interface [polypeptide binding]; other site 1045855002754 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1045855002755 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1045855002756 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1045855002757 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1045855002758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045855002759 dimerization interface [polypeptide binding]; other site 1045855002760 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855002761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855002762 metal binding site [ion binding]; metal-binding site 1045855002763 active site 1045855002764 I-site; other site 1045855002765 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045855002766 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1045855002767 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1045855002768 Domain of unknown function DUF21; Region: DUF21; pfam01595 1045855002769 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1045855002770 Transporter associated domain; Region: CorC_HlyC; smart01091 1045855002771 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1045855002772 nucleophilic elbow; other site 1045855002773 catalytic triad; other site 1045855002774 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1045855002775 active site 1045855002776 DNA binding site [nucleotide binding] 1045855002777 SpoVR family protein; Provisional; Region: PRK11767 1045855002778 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1045855002779 hypothetical protein; Provisional; Region: PRK05325 1045855002780 PrkA family serine protein kinase; Provisional; Region: PRK15455 1045855002781 AAA ATPase domain; Region: AAA_16; pfam13191 1045855002782 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1045855002783 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1045855002784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1045855002785 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1045855002786 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1045855002787 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1045855002788 active site 1045855002789 Zn binding site [ion binding]; other site 1045855002790 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1045855002791 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1045855002792 active site 1045855002793 Zn binding site [ion binding]; other site 1045855002794 CHASE2 domain; Region: CHASE2; pfam05226 1045855002795 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855002796 active site 1045855002797 I-site; other site 1045855002798 metal binding site [ion binding]; metal-binding site 1045855002799 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1045855002800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045855002801 hypothetical protein; Provisional; Region: PRK06132 1045855002802 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1045855002803 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1045855002804 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1045855002805 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1045855002806 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1045855002807 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1045855002808 putative catalytic residues [active] 1045855002809 putative nucleotide binding site [chemical binding]; other site 1045855002810 putative aspartate binding site [chemical binding]; other site 1045855002811 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1045855002812 dimer interface [polypeptide binding]; other site 1045855002813 putative threonine allosteric regulatory site; other site 1045855002814 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1045855002815 putative threonine allosteric regulatory site; other site 1045855002816 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1045855002817 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1045855002818 homoserine kinase; Provisional; Region: PRK01212 1045855002819 threonine synthase; Validated; Region: PRK09225 1045855002820 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1045855002821 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855002822 catalytic residue [active] 1045855002823 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1045855002824 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045855002825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1045855002826 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1045855002827 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045855002828 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1045855002829 putative hydrophobic ligand binding site [chemical binding]; other site 1045855002830 rhodanese superfamily protein; Provisional; Region: PRK05320 1045855002831 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1045855002832 active site residue [active] 1045855002833 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855002834 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855002835 metal binding site [ion binding]; metal-binding site 1045855002836 active site 1045855002837 I-site; other site 1045855002838 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1045855002839 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1045855002840 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1045855002841 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1045855002842 Zn binding site [ion binding]; other site 1045855002843 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608 1045855002844 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1045855002845 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1045855002846 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1045855002847 Switch I; other site 1045855002848 Switch II; other site 1045855002849 septum formation inhibitor; Reviewed; Region: minC; PRK04596 1045855002850 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1045855002851 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1045855002852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1045855002853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1045855002854 Histidine kinase; Region: HisKA_3; pfam07730 1045855002855 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1045855002856 Mg2+ binding site [ion binding]; other site 1045855002857 G-X-G motif; other site 1045855002858 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045855002859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855002860 active site 1045855002861 phosphorylation site [posttranslational modification] 1045855002862 intermolecular recognition site; other site 1045855002863 dimerization interface [polypeptide binding]; other site 1045855002864 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045855002865 DNA binding residues [nucleotide binding] 1045855002866 dimerization interface [polypeptide binding]; other site 1045855002867 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1045855002868 hydrophobic ligand binding site; other site 1045855002869 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1045855002870 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045855002871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855002872 TPR motif; other site 1045855002873 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1045855002874 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1045855002875 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1045855002876 NAD binding site [chemical binding]; other site 1045855002877 ATP-grasp domain; Region: ATP-grasp; pfam02222 1045855002878 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1045855002879 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1045855002880 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1045855002881 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1045855002882 EF-hand domain pair; Region: EF_hand_5; pfam13499 1045855002883 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1045855002884 Ca2+ binding site [ion binding]; other site 1045855002885 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1045855002886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045855002887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045855002888 DNA binding residues [nucleotide binding] 1045855002889 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1045855002890 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1045855002891 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1045855002892 active site 1045855002893 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1045855002894 catalytic triad [active] 1045855002895 dimer interface [polypeptide binding]; other site 1045855002896 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1045855002897 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1045855002898 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1045855002899 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1045855002900 active site 1045855002901 dimer interface [polypeptide binding]; other site 1045855002902 motif 1; other site 1045855002903 motif 2; other site 1045855002904 motif 3; other site 1045855002905 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1045855002906 anticodon binding site; other site 1045855002907 translation initiation factor IF-3; Region: infC; TIGR00168 1045855002908 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1045855002909 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1045855002910 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1045855002911 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1045855002912 23S rRNA binding site [nucleotide binding]; other site 1045855002913 L21 binding site [polypeptide binding]; other site 1045855002914 L13 binding site [polypeptide binding]; other site 1045855002915 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1045855002916 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1045855002917 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1045855002918 dimer interface [polypeptide binding]; other site 1045855002919 motif 1; other site 1045855002920 active site 1045855002921 motif 2; other site 1045855002922 motif 3; other site 1045855002923 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1045855002924 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1045855002925 putative tRNA-binding site [nucleotide binding]; other site 1045855002926 B3/4 domain; Region: B3_4; pfam03483 1045855002927 tRNA synthetase B5 domain; Region: B5; smart00874 1045855002928 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1045855002929 dimer interface [polypeptide binding]; other site 1045855002930 motif 1; other site 1045855002931 motif 3; other site 1045855002932 motif 2; other site 1045855002933 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1045855002934 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1045855002935 IHF dimer interface [polypeptide binding]; other site 1045855002936 IHF - DNA interface [nucleotide binding]; other site 1045855002937 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1045855002938 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1045855002939 DNA binding residues [nucleotide binding] 1045855002940 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1045855002941 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1045855002942 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1045855002943 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1045855002944 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1045855002945 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1045855002946 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1045855002947 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1045855002948 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1045855002949 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1045855002950 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1045855002951 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1045855002952 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1045855002953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1045855002954 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1045855002955 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1045855002956 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1045855002957 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1045855002958 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 1045855002959 TraB family; Region: TraB; pfam01963 1045855002960 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1045855002961 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1045855002962 TPP-binding site; other site 1045855002963 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1045855002964 PYR/PP interface [polypeptide binding]; other site 1045855002965 dimer interface [polypeptide binding]; other site 1045855002966 TPP binding site [chemical binding]; other site 1045855002967 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1045855002968 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1045855002969 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1045855002970 active site 1045855002971 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1045855002972 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1045855002973 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1045855002974 active site 1045855002975 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1045855002976 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1045855002977 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1045855002978 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1045855002979 oxidative damage protection protein; Provisional; Region: PRK05408 1045855002980 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1045855002981 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1045855002982 minor groove reading motif; other site 1045855002983 helix-hairpin-helix signature motif; other site 1045855002984 substrate binding pocket [chemical binding]; other site 1045855002985 active site 1045855002986 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1045855002987 DNA binding and oxoG recognition site [nucleotide binding] 1045855002988 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1045855002989 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1045855002990 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045855002991 heat shock protein 90; Provisional; Region: PRK05218 1045855002992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855002993 ATP binding site [chemical binding]; other site 1045855002994 Mg2+ binding site [ion binding]; other site 1045855002995 G-X-G motif; other site 1045855002996 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1045855002997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855002998 S-adenosylmethionine binding site [chemical binding]; other site 1045855002999 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1045855003000 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1045855003001 active site 1045855003002 (T/H)XGH motif; other site 1045855003003 ferredoxin; Validated; Region: PRK07118 1045855003004 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1045855003005 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1045855003006 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1045855003007 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045855003008 active site 1045855003009 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045855003010 N-terminal plug; other site 1045855003011 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855003012 ligand-binding site [chemical binding]; other site 1045855003013 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045855003014 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1045855003015 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855003016 catalytic residue [active] 1045855003017 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1045855003018 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1045855003019 putative DNA binding site [nucleotide binding]; other site 1045855003020 putative Zn2+ binding site [ion binding]; other site 1045855003021 AsnC family; Region: AsnC_trans_reg; pfam01037 1045855003022 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1045855003023 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1045855003024 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1045855003025 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1045855003026 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1045855003027 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1045855003028 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1045855003029 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1045855003030 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1045855003031 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1045855003032 Protein export membrane protein; Region: SecD_SecF; pfam02355 1045855003033 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1045855003034 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1045855003035 substrate binding pocket [chemical binding]; other site 1045855003036 chain length determination region; other site 1045855003037 substrate-Mg2+ binding site; other site 1045855003038 catalytic residues [active] 1045855003039 aspartate-rich region 1; other site 1045855003040 active site lid residues [active] 1045855003041 aspartate-rich region 2; other site 1045855003042 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1045855003043 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1045855003044 dimer interface [polypeptide binding]; other site 1045855003045 ssDNA binding site [nucleotide binding]; other site 1045855003046 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045855003047 Predicted membrane protein [Function unknown]; Region: COG1297 1045855003048 putative oligopeptide transporter, OPT family; Region: TIGR00733 1045855003049 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1045855003050 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045855003051 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045855003052 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045855003053 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045855003054 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1045855003055 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1045855003056 carbon starvation protein A; Provisional; Region: PRK15015 1045855003057 Carbon starvation protein CstA; Region: CstA; pfam02554 1045855003058 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1045855003059 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1045855003060 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1045855003061 oligomer interface [polypeptide binding]; other site 1045855003062 metal binding site [ion binding]; metal-binding site 1045855003063 metal binding site [ion binding]; metal-binding site 1045855003064 putative Cl binding site [ion binding]; other site 1045855003065 basic sphincter; other site 1045855003066 hydrophobic gate; other site 1045855003067 periplasmic entrance; other site 1045855003068 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 1045855003069 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1045855003070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1045855003071 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1045855003072 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1045855003073 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1045855003074 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1045855003075 dimer interface [polypeptide binding]; other site 1045855003076 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1045855003077 active site 1045855003078 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045855003079 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1045855003080 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1045855003081 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1045855003082 NlpC/P60 family; Region: NLPC_P60; pfam00877 1045855003083 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1045855003084 NlpC/P60 family; Region: NLPC_P60; pfam00877 1045855003085 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1045855003086 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045855003087 Predicted membrane protein [Function unknown]; Region: COG2311 1045855003088 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1045855003089 glutathione reductase; Validated; Region: PRK06116 1045855003090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045855003091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045855003092 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1045855003093 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1045855003094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855003095 putative substrate translocation pore; other site 1045855003096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855003097 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1045855003098 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045855003099 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855003100 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1045855003101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1045855003102 MarR family; Region: MarR_2; cl17246 1045855003103 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1045855003104 signal recognition particle protein; Provisional; Region: PRK10867 1045855003105 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1045855003106 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1045855003107 P loop; other site 1045855003108 GTP binding site [chemical binding]; other site 1045855003109 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1045855003110 Nitronate monooxygenase; Region: NMO; pfam03060 1045855003111 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1045855003112 FMN binding site [chemical binding]; other site 1045855003113 substrate binding site [chemical binding]; other site 1045855003114 putative catalytic residue [active] 1045855003115 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1045855003116 homodimer interface [polypeptide binding]; other site 1045855003117 substrate-cofactor binding pocket; other site 1045855003118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855003119 catalytic residue [active] 1045855003120 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1045855003121 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1045855003122 RimM N-terminal domain; Region: RimM; pfam01782 1045855003123 PRC-barrel domain; Region: PRC; pfam05239 1045855003124 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1045855003125 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1045855003126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045855003127 RNA binding surface [nucleotide binding]; other site 1045855003128 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1045855003129 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1045855003130 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045855003131 N-terminal plug; other site 1045855003132 ligand-binding site [chemical binding]; other site 1045855003133 Phosphotransferase enzyme family; Region: APH; pfam01636 1045855003134 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1045855003135 active site 1045855003136 ATP binding site [chemical binding]; other site 1045855003137 substrate binding site [chemical binding]; other site 1045855003138 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1045855003139 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1045855003140 dimer interface [polypeptide binding]; other site 1045855003141 active site 1045855003142 heme binding site [chemical binding]; other site 1045855003143 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1045855003144 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1045855003145 MutS domain I; Region: MutS_I; pfam01624 1045855003146 MutS domain II; Region: MutS_II; pfam05188 1045855003147 MutS domain III; Region: MutS_III; pfam05192 1045855003148 MutS domain V; Region: MutS_V; pfam00488 1045855003149 Walker A/P-loop; other site 1045855003150 ATP binding site [chemical binding]; other site 1045855003151 Q-loop/lid; other site 1045855003152 ABC transporter signature motif; other site 1045855003153 Walker B; other site 1045855003154 D-loop; other site 1045855003155 H-loop/switch region; other site 1045855003156 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1045855003157 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045855003158 dimerization interface [polypeptide binding]; other site 1045855003159 putative DNA binding site [nucleotide binding]; other site 1045855003160 putative Zn2+ binding site [ion binding]; other site 1045855003161 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1045855003162 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1045855003163 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1045855003164 Predicted transporter component [General function prediction only]; Region: COG2391 1045855003165 Predicted transporter component [General function prediction only]; Region: COG2391 1045855003166 Sulphur transport; Region: Sulf_transp; pfam04143 1045855003167 Putative phosphatase (DUF442); Region: DUF442; cl17385 1045855003168 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1045855003169 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1045855003170 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1045855003171 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1045855003172 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1045855003173 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1045855003174 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1045855003175 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 1045855003176 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1045855003177 DsrE/DsrF-like family; Region: DrsE; cl00672 1045855003178 Peptidase propeptide and YPEB domain; Region: PepSY_2; cl17877 1045855003179 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1045855003180 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1045855003181 dimerization domain [polypeptide binding]; other site 1045855003182 dimer interface [polypeptide binding]; other site 1045855003183 catalytic residues [active] 1045855003184 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1045855003185 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045855003186 catalytic residues [active] 1045855003187 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1045855003188 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1045855003189 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045855003190 DsbD alpha interface [polypeptide binding]; other site 1045855003191 catalytic residues [active] 1045855003192 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045855003193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855003194 active site 1045855003195 dimerization interface [polypeptide binding]; other site 1045855003196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855003197 DNA binding site [nucleotide binding] 1045855003198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855003199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855003200 phosphorylation site [posttranslational modification] 1045855003201 dimer interface [polypeptide binding]; other site 1045855003202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855003203 ATP binding site [chemical binding]; other site 1045855003204 Mg2+ binding site [ion binding]; other site 1045855003205 G-X-G motif; other site 1045855003206 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1045855003207 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1045855003208 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1045855003209 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1045855003210 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1045855003211 ABC1 family; Region: ABC1; cl17513 1045855003212 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1045855003213 LexA repressor; Validated; Region: PRK00215 1045855003214 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1045855003215 Catalytic site [active] 1045855003216 recombinase A; Provisional; Region: recA; PRK09354 1045855003217 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1045855003218 hexamer interface [polypeptide binding]; other site 1045855003219 Walker A motif; other site 1045855003220 ATP binding site [chemical binding]; other site 1045855003221 Walker B motif; other site 1045855003222 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1045855003223 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1045855003224 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1045855003225 motif 1; other site 1045855003226 active site 1045855003227 motif 2; other site 1045855003228 motif 3; other site 1045855003229 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1045855003230 DHHA1 domain; Region: DHHA1; pfam02272 1045855003231 carbon storage regulator; Provisional; Region: PRK01712 1045855003232 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045855003233 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1045855003234 putative NAD(P) binding site [chemical binding]; other site 1045855003235 active site 1045855003236 putative substrate binding site [chemical binding]; other site 1045855003237 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1045855003238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855003239 NAD(P) binding site [chemical binding]; other site 1045855003240 active site 1045855003241 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1045855003242 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1045855003243 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1045855003244 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1045855003245 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1045855003246 putative active site [active] 1045855003247 PhoH-like protein; Region: PhoH; pfam02562 1045855003248 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1045855003249 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1045855003250 catalytic triad [active] 1045855003251 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1045855003252 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1045855003253 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1045855003254 Class I aldolases; Region: Aldolase_Class_I; cl17187 1045855003255 Ferredoxin [Energy production and conversion]; Region: COG1146 1045855003256 4Fe-4S binding domain; Region: Fer4; cl02805 1045855003257 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1045855003258 poly(A) polymerase; Region: pcnB; TIGR01942 1045855003259 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1045855003260 active site 1045855003261 NTP binding site [chemical binding]; other site 1045855003262 metal binding triad [ion binding]; metal-binding site 1045855003263 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1045855003264 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1045855003265 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1045855003266 catalytic center binding site [active] 1045855003267 ATP binding site [chemical binding]; other site 1045855003268 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1045855003269 oligomerization interface [polypeptide binding]; other site 1045855003270 active site 1045855003271 metal binding site [ion binding]; metal-binding site 1045855003272 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1045855003273 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1045855003274 active site 1045855003275 ATP-binding site [chemical binding]; other site 1045855003276 pantoate-binding site; other site 1045855003277 HXXH motif; other site 1045855003278 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1045855003279 tetramerization interface [polypeptide binding]; other site 1045855003280 active site 1045855003281 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1045855003282 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1045855003283 active site 1045855003284 dimer interface [polypeptide binding]; other site 1045855003285 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1045855003286 dimer interface [polypeptide binding]; other site 1045855003287 active site 1045855003288 epoxyqueuosine reductase; Region: TIGR00276 1045855003289 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1045855003290 putative carbohydrate kinase; Provisional; Region: PRK10565 1045855003291 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1045855003292 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1045855003293 putative substrate binding site [chemical binding]; other site 1045855003294 putative ATP binding site [chemical binding]; other site 1045855003295 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1045855003296 AMIN domain; Region: AMIN; pfam11741 1045855003297 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1045855003298 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1045855003299 active site 1045855003300 metal binding site [ion binding]; metal-binding site 1045855003301 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1045855003302 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1045855003303 ATP binding site [chemical binding]; other site 1045855003304 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1045855003305 Uncharacterized conserved protein [Function unknown]; Region: COG3358 1045855003306 TraB family; Region: TraB; pfam01963 1045855003307 ferredoxin; Provisional; Region: PRK08764 1045855003308 Putative Fe-S cluster; Region: FeS; pfam04060 1045855003309 4Fe-4S binding domain; Region: Fer4; cl02805 1045855003310 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1045855003311 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1045855003312 active site 1045855003313 HIGH motif; other site 1045855003314 KMSKS motif; other site 1045855003315 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1045855003316 anticodon binding site; other site 1045855003317 tRNA binding surface [nucleotide binding]; other site 1045855003318 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1045855003319 dimer interface [polypeptide binding]; other site 1045855003320 putative tRNA-binding site [nucleotide binding]; other site 1045855003321 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1045855003322 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1045855003323 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855003324 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1045855003325 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1045855003326 trimer interface [polypeptide binding]; other site 1045855003327 active site 1045855003328 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1045855003329 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1045855003330 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1045855003331 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1045855003332 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1045855003333 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045855003334 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045855003335 catalytic residue [active] 1045855003336 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045855003337 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1045855003338 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045855003339 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1045855003340 Protein export membrane protein; Region: SecD_SecF; cl14618 1045855003341 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045855003342 Protein export membrane protein; Region: SecD_SecF; cl14618 1045855003343 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1045855003344 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1045855003345 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1045855003346 Cu(I) binding site [ion binding]; other site 1045855003347 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1045855003348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855003349 S-adenosylmethionine binding site [chemical binding]; other site 1045855003350 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1045855003351 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1045855003352 Tetramer interface [polypeptide binding]; other site 1045855003353 active site 1045855003354 FMN-binding site [chemical binding]; other site 1045855003355 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1045855003356 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1045855003357 dimerization interface [polypeptide binding]; other site 1045855003358 ligand binding site [chemical binding]; other site 1045855003359 NADP binding site [chemical binding]; other site 1045855003360 catalytic site [active] 1045855003361 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1045855003362 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1045855003363 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1045855003364 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1045855003365 active site 1045855003366 substrate binding site [chemical binding]; other site 1045855003367 metal binding site [ion binding]; metal-binding site 1045855003368 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1045855003369 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1045855003370 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1045855003371 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1045855003372 classical (c) SDRs; Region: SDR_c; cd05233 1045855003373 NAD(P) binding site [chemical binding]; other site 1045855003374 active site 1045855003375 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1045855003376 substrate binding site [chemical binding]; other site 1045855003377 dimer interface [polypeptide binding]; other site 1045855003378 catalytic triad [active] 1045855003379 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1045855003380 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1045855003381 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1045855003382 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1045855003383 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1045855003384 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1045855003385 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1045855003386 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1045855003387 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1045855003388 putative dimer interface [polypeptide binding]; other site 1045855003389 [2Fe-2S] cluster binding site [ion binding]; other site 1045855003390 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1045855003391 SLBB domain; Region: SLBB; pfam10531 1045855003392 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1045855003393 NADH dehydrogenase subunit G; Validated; Region: PRK09129 1045855003394 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045855003395 catalytic loop [active] 1045855003396 iron binding site [ion binding]; other site 1045855003397 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1045855003398 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045855003399 molybdopterin cofactor binding site; other site 1045855003400 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1045855003401 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1045855003402 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1045855003403 4Fe-4S binding domain; Region: Fer4; cl02805 1045855003404 4Fe-4S binding domain; Region: Fer4; cl02805 1045855003405 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1045855003406 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1045855003407 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1045855003408 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1045855003409 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1045855003410 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1045855003411 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1045855003412 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1045855003413 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1045855003414 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1045855003415 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1045855003416 dihydropteroate synthase; Region: DHPS; TIGR01496 1045855003417 substrate binding pocket [chemical binding]; other site 1045855003418 dimer interface [polypeptide binding]; other site 1045855003419 inhibitor binding site; inhibition site 1045855003420 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1045855003421 AAA domain; Region: AAA_33; pfam13671 1045855003422 ATP-binding site [chemical binding]; other site 1045855003423 Gluconate-6-phosphate binding site [chemical binding]; other site 1045855003424 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1045855003425 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1045855003426 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1045855003427 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1045855003428 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1045855003429 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1045855003430 HflK protein; Region: hflK; TIGR01933 1045855003431 HflC protein; Region: hflC; TIGR01932 1045855003432 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1045855003433 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1045855003434 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1045855003435 GDP-binding site [chemical binding]; other site 1045855003436 ACT binding site; other site 1045855003437 IMP binding site; other site 1045855003438 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1045855003439 aspartate aminotransferase; Provisional; Region: PRK06108 1045855003440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045855003441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855003442 homodimer interface [polypeptide binding]; other site 1045855003443 catalytic residue [active] 1045855003444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045855003445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855003446 active site 1045855003447 phosphorylation site [posttranslational modification] 1045855003448 intermolecular recognition site; other site 1045855003449 dimerization interface [polypeptide binding]; other site 1045855003450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855003451 DNA binding site [nucleotide binding] 1045855003452 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1045855003453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855003454 Mg2+ binding site [ion binding]; other site 1045855003455 G-X-G motif; other site 1045855003456 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045855003457 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1045855003458 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855003459 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1045855003460 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 1045855003461 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1045855003462 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1045855003463 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855003464 ATP binding site [chemical binding]; other site 1045855003465 putative Mg++ binding site [ion binding]; other site 1045855003466 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1045855003467 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1045855003468 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1045855003469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1045855003470 AAA domain; Region: AAA_33; pfam13671 1045855003471 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1045855003472 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1045855003473 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1045855003474 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1045855003475 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1045855003476 putative active site [active] 1045855003477 FtsH Extracellular; Region: FtsH_ext; pfam06480 1045855003478 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1045855003479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855003480 Walker A motif; other site 1045855003481 ATP binding site [chemical binding]; other site 1045855003482 Walker B motif; other site 1045855003483 arginine finger; other site 1045855003484 Peptidase family M41; Region: Peptidase_M41; pfam01434 1045855003485 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045855003486 Protein of unknown function (DUF763); Region: DUF763; pfam05559 1045855003487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855003488 putative transporter; Provisional; Region: PRK10504 1045855003489 putative substrate translocation pore; other site 1045855003490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1045855003491 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1045855003492 putative addiction module antidote; Region: doc_partner; TIGR02609 1045855003493 LexA repressor; Provisional; Region: PRK12423 1045855003494 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1045855003495 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1045855003496 Catalytic site [active] 1045855003497 Cell division inhibitor SulA; Region: SulA; cl01880 1045855003498 DNA Polymerase Y-family; Region: PolY_like; cd03468 1045855003499 active site 1045855003500 DNA binding site [nucleotide binding] 1045855003501 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1045855003502 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1045855003503 putative active site [active] 1045855003504 putative PHP Thumb interface [polypeptide binding]; other site 1045855003505 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1045855003506 active site 1045855003507 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1045855003508 generic binding surface I; other site 1045855003509 generic binding surface II; other site 1045855003510 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 1045855003511 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1045855003512 PAS fold; Region: PAS_3; pfam08447 1045855003513 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1045855003514 PAS domain S-box; Region: sensory_box; TIGR00229 1045855003515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855003516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855003517 dimer interface [polypeptide binding]; other site 1045855003518 phosphorylation site [posttranslational modification] 1045855003519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855003520 ATP binding site [chemical binding]; other site 1045855003521 Mg2+ binding site [ion binding]; other site 1045855003522 G-X-G motif; other site 1045855003523 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855003524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855003525 active site 1045855003526 phosphorylation site [posttranslational modification] 1045855003527 intermolecular recognition site; other site 1045855003528 dimerization interface [polypeptide binding]; other site 1045855003529 hydroperoxidase II; Provisional; Region: katE; PRK11249 1045855003530 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1045855003531 heme binding pocket [chemical binding]; other site 1045855003532 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1045855003533 domain interactions; other site 1045855003534 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855003535 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855003536 metal binding site [ion binding]; metal-binding site 1045855003537 active site 1045855003538 I-site; other site 1045855003539 glycine dehydrogenase; Provisional; Region: PRK05367 1045855003540 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045855003541 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855003542 catalytic residue [active] 1045855003543 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1045855003544 tetramer interface [polypeptide binding]; other site 1045855003545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855003546 catalytic residue [active] 1045855003547 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1045855003548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855003549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855003550 HI0933-like protein; Region: HI0933_like; pfam03486 1045855003551 YaeQ protein; Region: YaeQ; pfam07152 1045855003552 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1045855003553 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1045855003554 probable active site [active] 1045855003555 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1045855003556 DNA-binding site [nucleotide binding]; DNA binding site 1045855003557 RNA-binding motif; other site 1045855003558 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1045855003559 hypothetical protein; Validated; Region: PRK00029 1045855003560 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045855003561 active site 1045855003562 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1045855003563 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1045855003564 ATP binding site [chemical binding]; other site 1045855003565 Mg++ binding site [ion binding]; other site 1045855003566 motif III; other site 1045855003567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855003568 nucleotide binding region [chemical binding]; other site 1045855003569 ATP-binding site [chemical binding]; other site 1045855003570 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1045855003571 putative RNA binding site [nucleotide binding]; other site 1045855003572 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1045855003573 putative RNAase interaction site [polypeptide binding]; other site 1045855003574 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 1045855003575 putative active site [active] 1045855003576 Zn binding site [ion binding]; other site 1045855003577 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1045855003578 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1045855003579 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1045855003580 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1045855003581 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1045855003582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1045855003583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855003584 S-adenosylmethionine binding site [chemical binding]; other site 1045855003585 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 1045855003586 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1045855003587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855003588 ATP binding site [chemical binding]; other site 1045855003589 putative Mg++ binding site [ion binding]; other site 1045855003590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855003591 nucleotide binding region [chemical binding]; other site 1045855003592 ATP-binding site [chemical binding]; other site 1045855003593 DEAD/H associated; Region: DEAD_assoc; pfam08494 1045855003594 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1045855003595 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1045855003596 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855003597 ATP binding site [chemical binding]; other site 1045855003598 putative Mg++ binding site [ion binding]; other site 1045855003599 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855003600 nucleotide binding region [chemical binding]; other site 1045855003601 ATP-binding site [chemical binding]; other site 1045855003602 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1045855003603 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1045855003604 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1045855003605 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1045855003606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855003607 active site 1045855003608 dimerization interface [polypeptide binding]; other site 1045855003609 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855003610 DNA binding site [nucleotide binding] 1045855003611 sensory histidine kinase CreC; Provisional; Region: PRK11100 1045855003612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045855003613 dimerization interface [polypeptide binding]; other site 1045855003614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855003615 dimer interface [polypeptide binding]; other site 1045855003616 phosphorylation site [posttranslational modification] 1045855003617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855003618 ATP binding site [chemical binding]; other site 1045855003619 Mg2+ binding site [ion binding]; other site 1045855003620 G-X-G motif; other site 1045855003621 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1045855003622 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045855003623 inhibitor-cofactor binding pocket; inhibition site 1045855003624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855003625 catalytic residue [active] 1045855003626 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1045855003627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045855003628 non-specific DNA binding site [nucleotide binding]; other site 1045855003629 salt bridge; other site 1045855003630 sequence-specific DNA binding site [nucleotide binding]; other site 1045855003631 Cupin domain; Region: Cupin_2; pfam07883 1045855003632 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1045855003633 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1045855003634 NAD(P) binding site [chemical binding]; other site 1045855003635 catalytic residues [active] 1045855003636 PIN domain; Region: PIN_3; cl17397 1045855003637 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1045855003638 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1045855003639 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1045855003640 dimer interface [polypeptide binding]; other site 1045855003641 active site 1045855003642 catalytic residue [active] 1045855003643 metabolite-proton symporter; Region: 2A0106; TIGR00883 1045855003644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855003645 putative substrate translocation pore; other site 1045855003646 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1045855003647 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1045855003648 active site 1045855003649 NTP binding site [chemical binding]; other site 1045855003650 metal binding triad [ion binding]; metal-binding site 1045855003651 antibiotic binding site [chemical binding]; other site 1045855003652 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1045855003653 Hemerythrin; Region: Hemerythrin; cd12107 1045855003654 Fe binding site [ion binding]; other site 1045855003655 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1045855003656 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1045855003657 NAD binding site [chemical binding]; other site 1045855003658 homodimer interface [polypeptide binding]; other site 1045855003659 active site 1045855003660 substrate binding site [chemical binding]; other site 1045855003661 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1045855003662 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1045855003663 NADP binding site [chemical binding]; other site 1045855003664 active site 1045855003665 putative substrate binding site [chemical binding]; other site 1045855003666 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1045855003667 active site 1045855003668 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1045855003669 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 1045855003670 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1045855003671 putative active site [active] 1045855003672 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1045855003673 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1045855003674 putative trimer interface [polypeptide binding]; other site 1045855003675 putative active site [active] 1045855003676 putative substrate binding site [chemical binding]; other site 1045855003677 putative CoA binding site [chemical binding]; other site 1045855003678 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1045855003679 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1045855003680 trimer interface [polypeptide binding]; other site 1045855003681 active site 1045855003682 substrate binding site [chemical binding]; other site 1045855003683 CoA binding site [chemical binding]; other site 1045855003684 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1045855003685 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1045855003686 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1045855003687 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1045855003688 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1045855003689 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1045855003690 NADP-binding site; other site 1045855003691 homotetramer interface [polypeptide binding]; other site 1045855003692 substrate binding site [chemical binding]; other site 1045855003693 homodimer interface [polypeptide binding]; other site 1045855003694 active site 1045855003695 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1045855003696 putative glycosyl transferase; Provisional; Region: PRK10307 1045855003697 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1045855003698 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1045855003699 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1045855003700 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1045855003701 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1045855003702 polysaccharide export protein Wza; Provisional; Region: PRK15078 1045855003703 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1045855003704 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1045855003705 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1045855003706 active site 1045855003707 tyrosine kinase; Provisional; Region: PRK11519 1045855003708 Chain length determinant protein; Region: Wzz; pfam02706 1045855003709 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1045855003710 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045855003711 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1045855003712 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1045855003713 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1045855003714 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1045855003715 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1045855003716 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1045855003717 catalytic triad [active] 1045855003718 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1045855003719 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1045855003720 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1045855003721 putative aminotransferase; Validated; Region: PRK07480 1045855003722 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045855003723 inhibitor-cofactor binding pocket; inhibition site 1045855003724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855003725 catalytic residue [active] 1045855003726 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1045855003727 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1045855003728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855003729 spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187 1045855003730 Walker A/P-loop; other site 1045855003731 ATP binding site [chemical binding]; other site 1045855003732 Q-loop/lid; other site 1045855003733 ABC transporter signature motif; other site 1045855003734 Walker B; other site 1045855003735 D-loop; other site 1045855003736 H-loop/switch region; other site 1045855003737 TOBE domain; Region: TOBE_2; pfam08402 1045855003738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855003739 dimer interface [polypeptide binding]; other site 1045855003740 conserved gate region; other site 1045855003741 putative PBP binding loops; other site 1045855003742 ABC-ATPase subunit interface; other site 1045855003743 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1045855003744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855003745 dimer interface [polypeptide binding]; other site 1045855003746 conserved gate region; other site 1045855003747 putative PBP binding loops; other site 1045855003748 ABC-ATPase subunit interface; other site 1045855003749 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1045855003750 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045855003751 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855003752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855003753 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1045855003754 putative substrate translocation pore; other site 1045855003755 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1045855003756 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1045855003757 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1045855003758 NAD(P) binding site [chemical binding]; other site 1045855003759 catalytic residues [active] 1045855003760 ATP-dependent DNA ligase; Validated; Region: PRK09247 1045855003761 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1045855003762 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1045855003763 active site 1045855003764 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1045855003765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855003766 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1045855003767 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1045855003768 FAD binding pocket [chemical binding]; other site 1045855003769 FAD binding motif [chemical binding]; other site 1045855003770 phosphate binding motif [ion binding]; other site 1045855003771 beta-alpha-beta structure motif; other site 1045855003772 NAD binding pocket [chemical binding]; other site 1045855003773 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045855003774 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1045855003775 catalytic loop [active] 1045855003776 iron binding site [ion binding]; other site 1045855003777 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1045855003778 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1045855003779 putative di-iron ligands [ion binding]; other site 1045855003780 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1045855003781 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1045855003782 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1045855003783 active site 1045855003784 Zn binding site [ion binding]; other site 1045855003785 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1045855003786 catalytic residues [active] 1045855003787 dimer interface [polypeptide binding]; other site 1045855003788 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1045855003789 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1045855003790 FAD binding pocket [chemical binding]; other site 1045855003791 FAD binding motif [chemical binding]; other site 1045855003792 phosphate binding motif [ion binding]; other site 1045855003793 beta-alpha-beta structure motif; other site 1045855003794 NAD binding pocket [chemical binding]; other site 1045855003795 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1045855003796 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045855003797 RNA binding surface [nucleotide binding]; other site 1045855003798 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1045855003799 active site 1045855003800 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1045855003801 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1045855003802 YciI-like protein; Reviewed; Region: PRK11370 1045855003803 BolA-like protein; Region: BolA; pfam01722 1045855003804 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045855003805 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045855003806 DNA binding site [nucleotide binding] 1045855003807 domain linker motif; other site 1045855003808 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1045855003809 dimerization interface [polypeptide binding]; other site 1045855003810 ligand binding site [chemical binding]; other site 1045855003811 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1045855003812 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855003813 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855003814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 1045855003815 Putative glucoamylase; Region: Glycoamylase; pfam10091 1045855003816 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1045855003817 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1045855003818 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1045855003819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855003820 putative PBP binding loops; other site 1045855003821 dimer interface [polypeptide binding]; other site 1045855003822 ABC-ATPase subunit interface; other site 1045855003823 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1045855003824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855003825 dimer interface [polypeptide binding]; other site 1045855003826 conserved gate region; other site 1045855003827 putative PBP binding loops; other site 1045855003828 ABC-ATPase subunit interface; other site 1045855003829 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1045855003830 sugar binding site [chemical binding]; other site 1045855003831 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1045855003832 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1045855003833 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1045855003834 active site 1045855003835 intersubunit interface [polypeptide binding]; other site 1045855003836 catalytic residue [active] 1045855003837 phosphogluconate dehydratase; Validated; Region: PRK09054 1045855003838 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1045855003839 glucokinase, proteobacterial type; Region: glk; TIGR00749 1045855003840 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1045855003841 nucleotide binding site [chemical binding]; other site 1045855003842 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1045855003843 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1045855003844 Walker A/P-loop; other site 1045855003845 ATP binding site [chemical binding]; other site 1045855003846 Q-loop/lid; other site 1045855003847 ABC transporter signature motif; other site 1045855003848 Walker B; other site 1045855003849 D-loop; other site 1045855003850 H-loop/switch region; other site 1045855003851 TOBE domain; Region: TOBE_2; pfam08402 1045855003852 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1045855003853 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1045855003854 Walker A/P-loop; other site 1045855003855 ATP binding site [chemical binding]; other site 1045855003856 Q-loop/lid; other site 1045855003857 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1045855003858 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1045855003859 ABC transporter signature motif; other site 1045855003860 Walker B; other site 1045855003861 D-loop; other site 1045855003862 H-loop/switch region; other site 1045855003863 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1045855003864 FtsZ protein binding site [polypeptide binding]; other site 1045855003865 Ligase N family; Region: LIGANc; smart00532 1045855003866 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1045855003867 nucleotide binding pocket [chemical binding]; other site 1045855003868 K-X-D-G motif; other site 1045855003869 catalytic site [active] 1045855003870 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1045855003871 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1045855003872 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1045855003873 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1045855003874 Dimer interface [polypeptide binding]; other site 1045855003875 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1045855003876 putative active site [active] 1045855003877 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1045855003878 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1045855003879 motif 1; other site 1045855003880 dimer interface [polypeptide binding]; other site 1045855003881 active site 1045855003882 motif 2; other site 1045855003883 motif 3; other site 1045855003884 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 1045855003885 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1045855003886 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1045855003887 DNA gyrase subunit A; Validated; Region: PRK05560 1045855003888 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1045855003889 CAP-like domain; other site 1045855003890 active site 1045855003891 primary dimer interface [polypeptide binding]; other site 1045855003892 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045855003893 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045855003894 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045855003895 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045855003896 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045855003897 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045855003898 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1045855003899 MG2 domain; Region: A2M_N; pfam01835 1045855003900 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1045855003901 surface patch; other site 1045855003902 thioester region; other site 1045855003903 specificity defining residues; other site 1045855003904 penicillin-binding protein 1C; Provisional; Region: PRK11240 1045855003905 Transglycosylase; Region: Transgly; pfam00912 1045855003906 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1045855003907 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1045855003908 Ferritin-like domain; Region: Ferritin; pfam00210 1045855003909 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1045855003910 dinuclear metal binding motif [ion binding]; other site 1045855003911 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1045855003912 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1045855003913 catalytic triad [active] 1045855003914 dimer interface [polypeptide binding]; other site 1045855003915 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1045855003916 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1045855003917 putative dimer interface [polypeptide binding]; other site 1045855003918 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1045855003919 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1045855003920 HSP70 interaction site [polypeptide binding]; other site 1045855003921 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1045855003922 substrate binding site [polypeptide binding]; other site 1045855003923 dimer interface [polypeptide binding]; other site 1045855003924 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855003925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855003926 active site 1045855003927 phosphorylation site [posttranslational modification] 1045855003928 intermolecular recognition site; other site 1045855003929 dimerization interface [polypeptide binding]; other site 1045855003930 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1045855003931 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1045855003932 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1045855003933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045855003934 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1045855003935 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1045855003936 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045855003937 E3 interaction surface; other site 1045855003938 lipoyl attachment site [posttranslational modification]; other site 1045855003939 e3 binding domain; Region: E3_binding; pfam02817 1045855003940 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1045855003941 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1045855003942 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1045855003943 TPP-binding site [chemical binding]; other site 1045855003944 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1045855003945 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045855003946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045855003947 Coenzyme A binding pocket [chemical binding]; other site 1045855003948 Cupin superfamily protein; Region: Cupin_4; pfam08007 1045855003949 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1045855003950 adenylosuccinate lyase; Provisional; Region: PRK09285 1045855003951 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1045855003952 tetramer interface [polypeptide binding]; other site 1045855003953 active site 1045855003954 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1045855003955 Class II fumarases; Region: Fumarase_classII; cd01362 1045855003956 active site 1045855003957 tetramer interface [polypeptide binding]; other site 1045855003958 Penicillin amidase; Region: Penicil_amidase; pfam01804 1045855003959 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1045855003960 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1045855003961 active site 1045855003962 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1045855003963 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1045855003964 Cytochrome c; Region: Cytochrom_C; cl11414 1045855003965 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1045855003966 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1045855003967 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1045855003968 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045855003969 Walker A/P-loop; other site 1045855003970 ATP binding site [chemical binding]; other site 1045855003971 Q-loop/lid; other site 1045855003972 ABC transporter signature motif; other site 1045855003973 Walker B; other site 1045855003974 D-loop; other site 1045855003975 H-loop/switch region; other site 1045855003976 Predicted transcriptional regulators [Transcription]; Region: COG1725 1045855003977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045855003978 DNA-binding site [nucleotide binding]; DNA binding site 1045855003979 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1045855003980 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1045855003981 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1045855003982 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045855003983 hypothetical protein; Provisional; Region: PRK00846 1045855003984 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 1045855003985 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1045855003986 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1045855003987 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1045855003988 active site 1045855003989 HIGH motif; other site 1045855003990 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1045855003991 KMSKS motif; other site 1045855003992 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1045855003993 tRNA binding surface [nucleotide binding]; other site 1045855003994 anticodon binding site; other site 1045855003995 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 1045855003996 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1045855003997 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1045855003998 argininosuccinate synthase; Provisional; Region: PRK13820 1045855003999 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1045855004000 ANP binding site [chemical binding]; other site 1045855004001 Substrate Binding Site II [chemical binding]; other site 1045855004002 Substrate Binding Site I [chemical binding]; other site 1045855004003 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1045855004004 acetylornithine deacetylase; Provisional; Region: PRK08737 1045855004005 metal binding site [ion binding]; metal-binding site 1045855004006 acetylglutamate kinase; Provisional; Region: PRK04531 1045855004007 AAK_NAGK-fArgBP: N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-terminal...; Region: AAK_NAGK-fArgBP; cd04252 1045855004008 putative nucleotide binding site [chemical binding]; other site 1045855004009 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 1045855004010 DUF619 domain of various N-acetylglutamate Synthases (NAGS) of the urea (U) cycle of humans and fish; Region: DUF619-NAGS-U; cd04265 1045855004011 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1045855004012 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1045855004013 argininosuccinate lyase; Provisional; Region: PRK00855 1045855004014 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1045855004015 active sites [active] 1045855004016 tetramer interface [polypeptide binding]; other site 1045855004017 gamma-glutamyl kinase; Provisional; Region: PRK05429 1045855004018 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1045855004019 nucleotide binding site [chemical binding]; other site 1045855004020 substrate binding site [chemical binding]; other site 1045855004021 PUA domain; Region: PUA; pfam01472 1045855004022 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1045855004023 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1045855004024 putative catalytic cysteine [active] 1045855004025 Predicted acyl esterases [General function prediction only]; Region: COG2936 1045855004026 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1045855004027 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1045855004028 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1045855004029 seryl-tRNA synthetase; Provisional; Region: PRK05431 1045855004030 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1045855004031 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1045855004032 dimer interface [polypeptide binding]; other site 1045855004033 active site 1045855004034 motif 1; other site 1045855004035 motif 2; other site 1045855004036 motif 3; other site 1045855004037 LysR family transcriptional regulator; Provisional; Region: PRK14997 1045855004038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855004039 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1045855004040 putative dimerization interface [polypeptide binding]; other site 1045855004041 putative effector binding pocket; other site 1045855004042 FaeA-like protein; Region: FaeA; pfam04703 1045855004043 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1045855004044 Protein of unknown function DUF262; Region: DUF262; pfam03235 1045855004045 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1045855004046 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1045855004047 Protein of unknown function (DUF511); Region: DUF511; cl01114 1045855004048 Predicted acyl esterases [General function prediction only]; Region: COG2936 1045855004049 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1045855004050 ribonuclease D; Region: rnd; TIGR01388 1045855004051 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1045855004052 catalytic site [active] 1045855004053 putative active site [active] 1045855004054 putative substrate binding site [chemical binding]; other site 1045855004055 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1045855004056 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1045855004057 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1045855004058 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1045855004059 NAD(P) binding site [chemical binding]; other site 1045855004060 homotetramer interface [polypeptide binding]; other site 1045855004061 homodimer interface [polypeptide binding]; other site 1045855004062 active site 1045855004063 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 1045855004064 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1045855004065 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1045855004066 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1045855004067 active site 1045855004068 KMSKS motif; other site 1045855004069 heat shock protein HtpX; Provisional; Region: PRK05457 1045855004070 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1045855004071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1045855004072 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045855004073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1045855004074 active site 1045855004075 phosphorylation site [posttranslational modification] 1045855004076 intermolecular recognition site; other site 1045855004077 dimerization interface [polypeptide binding]; other site 1045855004078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045855004079 putative active site [active] 1045855004080 heme pocket [chemical binding]; other site 1045855004081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855004082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855004083 metal binding site [ion binding]; metal-binding site 1045855004084 active site 1045855004085 I-site; other site 1045855004086 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045855004087 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1045855004088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045855004089 FeS/SAM binding site; other site 1045855004090 elongation factor P; Validated; Region: PRK00529 1045855004091 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1045855004092 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1045855004093 RNA binding site [nucleotide binding]; other site 1045855004094 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1045855004095 RNA binding site [nucleotide binding]; other site 1045855004096 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1045855004097 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1045855004098 active site 1045855004099 putative substrate binding pocket [chemical binding]; other site 1045855004100 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1045855004101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855004102 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 1045855004103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855004104 motif II; other site 1045855004105 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1045855004106 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1045855004107 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1045855004108 Low-spin heme binding site [chemical binding]; other site 1045855004109 Putative water exit pathway; other site 1045855004110 Binuclear center (active site) [active] 1045855004111 Putative proton exit pathway; other site 1045855004112 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1045855004113 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1045855004114 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 1045855004115 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1045855004116 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1045855004117 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1045855004118 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1045855004119 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1045855004120 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1045855004121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1045855004122 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1045855004123 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1045855004124 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045855004125 metal-binding site [ion binding] 1045855004126 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045855004127 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1045855004128 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1045855004129 Family description; Region: DsbD_2; pfam13386 1045855004130 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1045855004131 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1045855004132 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1045855004133 ethanolamine permease; Region: 2A0305; TIGR00908 1045855004134 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1045855004135 activation loop (A-loop); other site 1045855004136 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045855004137 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045855004138 dihydroorotase; Reviewed; Region: PRK09236 1045855004139 Haemolytic domain; Region: Haemolytic; pfam01809 1045855004140 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1045855004141 Fic/DOC family; Region: Fic; pfam02661 1045855004142 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 1045855004143 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1045855004144 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1045855004145 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1045855004146 HlyD family secretion protein; Region: HlyD; pfam00529 1045855004147 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045855004148 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855004149 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045855004150 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1045855004151 Walker A/P-loop; other site 1045855004152 ATP binding site [chemical binding]; other site 1045855004153 Q-loop/lid; other site 1045855004154 ABC transporter signature motif; other site 1045855004155 Walker B; other site 1045855004156 D-loop; other site 1045855004157 H-loop/switch region; other site 1045855004158 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045855004159 Walker A/P-loop; other site 1045855004160 ATP binding site [chemical binding]; other site 1045855004161 Q-loop/lid; other site 1045855004162 ABC transporter signature motif; other site 1045855004163 Walker B; other site 1045855004164 D-loop; other site 1045855004165 H-loop/switch region; other site 1045855004166 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1045855004167 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1045855004168 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1045855004169 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1045855004170 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1045855004171 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1045855004172 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1045855004173 NAD(P) binding site [chemical binding]; other site 1045855004174 homotetramer interface [polypeptide binding]; other site 1045855004175 homodimer interface [polypeptide binding]; other site 1045855004176 active site 1045855004177 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1045855004178 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 1045855004179 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1045855004180 dimer interaction site [polypeptide binding]; other site 1045855004181 substrate-binding tunnel; other site 1045855004182 active site 1045855004183 catalytic site [active] 1045855004184 substrate binding site [chemical binding]; other site 1045855004185 phosphate acetyltransferase; Provisional; Region: PRK11890 1045855004186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855004187 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045855004188 NAD(P) binding site [chemical binding]; other site 1045855004189 active site 1045855004190 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1045855004191 propionate/acetate kinase; Provisional; Region: PRK12379 1045855004192 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1045855004193 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1045855004194 substrate binding pocket [chemical binding]; other site 1045855004195 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1045855004196 B12 binding site [chemical binding]; other site 1045855004197 cobalt ligand [ion binding]; other site 1045855004198 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1045855004199 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045855004200 dimerization interface [polypeptide binding]; other site 1045855004201 putative DNA binding site [nucleotide binding]; other site 1045855004202 putative Zn2+ binding site [ion binding]; other site 1045855004203 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1045855004204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855004205 S-adenosylmethionine binding site [chemical binding]; other site 1045855004206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1045855004207 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1045855004208 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1045855004209 active site 1045855004210 Bacterial Ig-like domain; Region: Big_5; pfam13205 1045855004211 Endonuclease I; Region: Endonuclease_1; pfam04231 1045855004212 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1045855004213 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1045855004214 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855004215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045855004216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855004217 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1045855004218 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1045855004219 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 1045855004220 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 1045855004221 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1045855004222 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1045855004223 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 1045855004224 TIGR02453 family protein; Region: TIGR02453 1045855004225 exonuclease I; Provisional; Region: sbcB; PRK11779 1045855004226 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1045855004227 active site 1045855004228 catalytic site [active] 1045855004229 substrate binding site [chemical binding]; other site 1045855004230 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1045855004231 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1045855004232 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1045855004233 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045855004234 kynureninase; Region: kynureninase; TIGR01814 1045855004235 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855004236 catalytic residue [active] 1045855004237 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 1045855004238 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1045855004239 active site clefts [active] 1045855004240 zinc binding site [ion binding]; other site 1045855004241 dimer interface [polypeptide binding]; other site 1045855004242 short chain dehydrogenase; Provisional; Region: PRK08339 1045855004243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855004244 NAD(P) binding site [chemical binding]; other site 1045855004245 active site 1045855004246 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1045855004247 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1045855004248 putative dimer interface [polypeptide binding]; other site 1045855004249 putative anticodon binding site; other site 1045855004250 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1045855004251 homodimer interface [polypeptide binding]; other site 1045855004252 motif 1; other site 1045855004253 motif 2; other site 1045855004254 active site 1045855004255 motif 3; other site 1045855004256 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1045855004257 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1045855004258 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1045855004259 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1045855004260 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1045855004261 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1045855004262 replicative DNA helicase; Provisional; Region: PRK08760 1045855004263 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1045855004264 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1045855004265 Walker A motif; other site 1045855004266 ATP binding site [chemical binding]; other site 1045855004267 Walker B motif; other site 1045855004268 DNA binding loops [nucleotide binding] 1045855004269 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1045855004270 DNA photolyase; Region: DNA_photolyase; pfam00875 1045855004271 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1045855004272 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045855004273 ligand binding site [chemical binding]; other site 1045855004274 Outer membrane efflux protein; Region: OEP; pfam02321 1045855004275 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1045855004276 carboxyltransferase (CT) interaction site; other site 1045855004277 biotinylation site [posttranslational modification]; other site 1045855004278 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1045855004279 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1045855004280 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045855004281 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045855004282 active site 1045855004283 catalytic tetrad [active] 1045855004284 MarR family; Region: MarR; pfam01047 1045855004285 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1045855004286 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1045855004287 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 1045855004288 putative C-terminal domain interface [polypeptide binding]; other site 1045855004289 putative GSH binding site (G-site) [chemical binding]; other site 1045855004290 putative dimer interface [polypeptide binding]; other site 1045855004291 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 1045855004292 putative N-terminal domain interface [polypeptide binding]; other site 1045855004293 putative dimer interface [polypeptide binding]; other site 1045855004294 putative substrate binding pocket (H-site) [chemical binding]; other site 1045855004295 Transcriptional activator [Transcription]; Region: ChrR; COG3806 1045855004296 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1045855004297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045855004298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855004299 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1045855004300 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1045855004301 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1045855004302 classical (c) SDRs; Region: SDR_c; cd05233 1045855004303 NAD(P) binding site [chemical binding]; other site 1045855004304 active site 1045855004305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855004306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045855004307 putative substrate translocation pore; other site 1045855004308 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1045855004309 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1045855004310 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1045855004311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1045855004312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1045855004313 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1045855004314 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1045855004315 active site 1045855004316 catalytic triad [active] 1045855004317 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1045855004318 SmpB-tmRNA interface; other site 1045855004319 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1045855004320 putative coenzyme Q binding site [chemical binding]; other site 1045855004321 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 1045855004322 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1045855004323 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1045855004324 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1045855004325 metal binding site 2 [ion binding]; metal-binding site 1045855004326 putative DNA binding helix; other site 1045855004327 metal binding site 1 [ion binding]; metal-binding site 1045855004328 dimer interface [polypeptide binding]; other site 1045855004329 structural Zn2+ binding site [ion binding]; other site 1045855004330 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1045855004331 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1045855004332 Walker A/P-loop; other site 1045855004333 ATP binding site [chemical binding]; other site 1045855004334 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1045855004335 ABC transporter signature motif; other site 1045855004336 Walker B; other site 1045855004337 D-loop; other site 1045855004338 H-loop/switch region; other site 1045855004339 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1045855004340 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 1045855004341 GrpE; Region: GrpE; pfam01025 1045855004342 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1045855004343 dimer interface [polypeptide binding]; other site 1045855004344 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1045855004345 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 1045855004346 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1045855004347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1045855004348 nucleotide binding site [chemical binding]; other site 1045855004349 chaperone protein DnaJ; Provisional; Region: PRK10767 1045855004350 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1045855004351 HSP70 interaction site [polypeptide binding]; other site 1045855004352 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1045855004353 Zn binding sites [ion binding]; other site 1045855004354 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1045855004355 dimer interface [polypeptide binding]; other site 1045855004356 prephenate dehydrogenase; Provisional; Region: PRK08818 1045855004357 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1045855004358 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1045855004359 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1045855004360 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1045855004361 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1045855004362 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1045855004363 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1045855004364 catalytic site [active] 1045855004365 subunit interface [polypeptide binding]; other site 1045855004366 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1045855004367 four helix bundle protein; Region: TIGR02436 1045855004368 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1045855004369 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045855004370 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1045855004371 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1045855004372 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045855004373 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045855004374 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1045855004375 IMP binding site; other site 1045855004376 dimer interface [polypeptide binding]; other site 1045855004377 interdomain contacts; other site 1045855004378 partial ornithine binding site; other site 1045855004379 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1045855004380 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1045855004381 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1045855004382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 1045855004383 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1045855004384 DHH family; Region: DHH; pfam01368 1045855004385 DHHA1 domain; Region: DHHA1; pfam02272 1045855004386 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1045855004387 inter-subunit interface; other site 1045855004388 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1045855004389 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1045855004390 iron-sulfur cluster [ion binding]; other site 1045855004391 [2Fe-2S] cluster binding site [ion binding]; other site 1045855004392 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1045855004393 beta subunit interface [polypeptide binding]; other site 1045855004394 alpha subunit interface [polypeptide binding]; other site 1045855004395 active site 1045855004396 substrate binding site [chemical binding]; other site 1045855004397 Fe binding site [ion binding]; other site 1045855004398 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1045855004399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855004400 S-adenosylmethionine binding site [chemical binding]; other site 1045855004401 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1045855004402 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1045855004403 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1045855004404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1045855004405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855004406 S-adenosylmethionine binding site [chemical binding]; other site 1045855004407 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1045855004408 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1045855004409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045855004410 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1045855004411 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1045855004412 Di-iron ligands [ion binding]; other site 1045855004413 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1045855004414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 1045855004415 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1045855004416 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1045855004417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045855004418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045855004419 DNA binding residues [nucleotide binding] 1045855004420 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1045855004421 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1045855004422 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1045855004423 substrate binding site [chemical binding]; other site 1045855004424 ligand binding site [chemical binding]; other site 1045855004425 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1045855004426 substrate binding site [chemical binding]; other site 1045855004427 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1045855004428 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 1045855004429 putative active site [active] 1045855004430 Zn binding site [ion binding]; other site 1045855004431 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 1045855004432 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1045855004433 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1045855004434 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1045855004435 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1045855004436 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1045855004437 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1045855004438 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1045855004439 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1045855004440 NAD binding site [chemical binding]; other site 1045855004441 homodimer interface [polypeptide binding]; other site 1045855004442 active site 1045855004443 substrate binding site [chemical binding]; other site 1045855004444 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1045855004445 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045855004446 NAD binding site [chemical binding]; other site 1045855004447 putative substrate binding site 2 [chemical binding]; other site 1045855004448 putative substrate binding site 1 [chemical binding]; other site 1045855004449 active site 1045855004450 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1045855004451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1045855004452 active site 1045855004453 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1045855004454 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045855004455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855004456 Walker A/P-loop; other site 1045855004457 ATP binding site [chemical binding]; other site 1045855004458 Q-loop/lid; other site 1045855004459 ABC transporter signature motif; other site 1045855004460 Walker B; other site 1045855004461 D-loop; other site 1045855004462 H-loop/switch region; other site 1045855004463 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045855004464 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1045855004465 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045855004466 active site 1045855004467 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1045855004468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855004469 S-adenosylmethionine binding site [chemical binding]; other site 1045855004470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1045855004471 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1045855004472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1045855004473 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 1045855004474 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1045855004475 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1045855004476 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1045855004477 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1045855004478 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1045855004479 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1045855004480 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045855004481 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1045855004482 catalytic site [active] 1045855004483 putative active site [active] 1045855004484 putative substrate binding site [chemical binding]; other site 1045855004485 dimer interface [polypeptide binding]; other site 1045855004486 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1045855004487 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1045855004488 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1045855004489 nucleoside/Zn binding site; other site 1045855004490 dimer interface [polypeptide binding]; other site 1045855004491 catalytic motif [active] 1045855004492 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 1045855004493 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1045855004494 dimer interface [polypeptide binding]; other site 1045855004495 motif 1; other site 1045855004496 active site 1045855004497 motif 2; other site 1045855004498 motif 3; other site 1045855004499 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1045855004500 anticodon binding site; other site 1045855004501 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1045855004502 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1045855004503 hinge; other site 1045855004504 active site 1045855004505 choline dehydrogenase; Validated; Region: PRK02106 1045855004506 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1045855004507 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1045855004508 NAD(P) binding site [chemical binding]; other site 1045855004509 catalytic residues [active] 1045855004510 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1045855004511 Rubredoxin; Region: Rubredoxin; pfam00301 1045855004512 iron binding site [ion binding]; other site 1045855004513 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1045855004514 Rubredoxin; Region: Rubredoxin; pfam00301 1045855004515 iron binding site [ion binding]; other site 1045855004516 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1045855004517 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1045855004518 Di-iron ligands [ion binding]; other site 1045855004519 Chorismate mutase type II; Region: CM_2; pfam01817 1045855004520 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1045855004521 Prephenate dehydratase; Region: PDT; pfam00800 1045855004522 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1045855004523 putative L-Phe binding site [chemical binding]; other site 1045855004524 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1045855004525 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1045855004526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855004527 catalytic residue [active] 1045855004528 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1045855004529 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1045855004530 Moco binding site; other site 1045855004531 metal coordination site [ion binding]; other site 1045855004532 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1045855004533 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1045855004534 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 1045855004535 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1045855004536 Restriction endonuclease; Region: Mrr_cat; pfam04471 1045855004537 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855004538 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855004539 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1045855004540 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045855004541 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1045855004542 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1045855004543 NADP binding site [chemical binding]; other site 1045855004544 substrate binding site [chemical binding]; other site 1045855004545 active site 1045855004546 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1045855004547 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 1045855004548 tetramer interface [polypeptide binding]; other site 1045855004549 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1045855004550 active site 1045855004551 metal binding site [ion binding]; metal-binding site 1045855004552 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1045855004553 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1045855004554 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1045855004555 FAD binding site [chemical binding]; other site 1045855004556 substrate binding pocket [chemical binding]; other site 1045855004557 catalytic base [active] 1045855004558 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1045855004559 active site 1045855004560 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1045855004561 putative FMN binding site [chemical binding]; other site 1045855004562 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1045855004563 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1045855004564 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1045855004565 GIY-YIG motif/motif A; other site 1045855004566 active site 1045855004567 catalytic site [active] 1045855004568 putative DNA binding site [nucleotide binding]; other site 1045855004569 metal binding site [ion binding]; metal-binding site 1045855004570 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1045855004571 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1045855004572 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045855004573 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1045855004574 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1045855004575 Ligand binding site; other site 1045855004576 oligomer interface; other site 1045855004577 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1045855004578 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1045855004579 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1045855004580 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045855004581 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1045855004582 Walker A/P-loop; other site 1045855004583 ATP binding site [chemical binding]; other site 1045855004584 Q-loop/lid; other site 1045855004585 ABC transporter signature motif; other site 1045855004586 Walker B; other site 1045855004587 D-loop; other site 1045855004588 H-loop/switch region; other site 1045855004589 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1045855004590 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1045855004591 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1045855004592 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1045855004593 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1045855004594 Competence protein; Region: Competence; pfam03772 1045855004595 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 1045855004596 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1045855004597 homotrimer interaction site [polypeptide binding]; other site 1045855004598 putative active site [active] 1045855004599 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1045855004600 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1045855004601 NAD(P) binding site [chemical binding]; other site 1045855004602 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1045855004603 iron-sulfur cluster [ion binding]; other site 1045855004604 [2Fe-2S] cluster binding site [ion binding]; other site 1045855004605 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1045855004606 [2Fe-2S] cluster binding site [ion binding]; other site 1045855004607 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045855004608 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1045855004609 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1045855004610 acyl-activating enzyme (AAE) consensus motif; other site 1045855004611 acyl-activating enzyme (AAE) consensus motif; other site 1045855004612 putative AMP binding site [chemical binding]; other site 1045855004613 putative active site [active] 1045855004614 putative CoA binding site [chemical binding]; other site 1045855004615 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1045855004616 CoenzymeA binding site [chemical binding]; other site 1045855004617 subunit interaction site [polypeptide binding]; other site 1045855004618 PHB binding site; other site 1045855004619 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1045855004620 [2Fe-2S] cluster binding site [ion binding]; other site 1045855004621 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1045855004622 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045855004623 catalytic loop [active] 1045855004624 iron binding site [ion binding]; other site 1045855004625 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1045855004626 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 1045855004627 tetramer interface [polypeptide binding]; other site 1045855004628 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1045855004629 active site 1045855004630 metal binding site [ion binding]; metal-binding site 1045855004631 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 1045855004632 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1045855004633 NAD binding site [chemical binding]; other site 1045855004634 catalytic residues [active] 1045855004635 2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220 1045855004636 4-oxalocrotonate decarboxylase; Region: catechol_dmpH; TIGR03218 1045855004637 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1045855004638 active site 1 [active] 1045855004639 dimer interface [polypeptide binding]; other site 1045855004640 hexamer interface [polypeptide binding]; other site 1045855004641 active site 2 [active] 1045855004642 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1045855004643 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1045855004644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855004645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045855004646 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1045855004647 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1045855004648 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1045855004649 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1045855004650 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1045855004651 FMN binding site [chemical binding]; other site 1045855004652 active site 1045855004653 substrate binding site [chemical binding]; other site 1045855004654 catalytic residue [active] 1045855004655 Putative methyltransferase; Region: Methyltransf_16; pfam10294 1045855004656 Flagellin N-methylase; Region: FliB; cl00497 1045855004657 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1045855004658 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1045855004659 PhnA protein; Region: PhnA; pfam03831 1045855004660 Cation efflux family; Region: Cation_efflux; pfam01545 1045855004661 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1045855004662 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045855004663 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1045855004664 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045855004665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855004666 Walker A/P-loop; other site 1045855004667 ATP binding site [chemical binding]; other site 1045855004668 Q-loop/lid; other site 1045855004669 ABC transporter signature motif; other site 1045855004670 Walker B; other site 1045855004671 D-loop; other site 1045855004672 H-loop/switch region; other site 1045855004673 C-N hydrolase family amidase; Provisional; Region: PRK10438 1045855004674 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1045855004675 putative active site [active] 1045855004676 catalytic triad [active] 1045855004677 dimer interface [polypeptide binding]; other site 1045855004678 multimer interface [polypeptide binding]; other site 1045855004679 methionine aminotransferase; Validated; Region: PRK09082 1045855004680 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045855004681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855004682 homodimer interface [polypeptide binding]; other site 1045855004683 catalytic residue [active] 1045855004684 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 1045855004685 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13543 1045855004686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855004687 Walker A/P-loop; other site 1045855004688 ATP binding site [chemical binding]; other site 1045855004689 Q-loop/lid; other site 1045855004690 ABC transporter signature motif; other site 1045855004691 Walker B; other site 1045855004692 D-loop; other site 1045855004693 H-loop/switch region; other site 1045855004694 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 1045855004695 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1045855004696 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 1045855004697 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 1045855004698 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 1045855004699 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1045855004700 Cytochrome c; Region: Cytochrom_C; cl11414 1045855004701 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1045855004702 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1045855004703 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1045855004704 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1045855004705 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1045855004706 catalytic residues [active] 1045855004707 central insert; other site 1045855004708 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1045855004709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045855004710 TPR motif; other site 1045855004711 TPR repeat; Region: TPR_11; pfam13414 1045855004712 binding surface 1045855004713 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1045855004714 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1045855004715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045855004716 DNA-binding site [nucleotide binding]; DNA binding site 1045855004717 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1045855004718 FCD domain; Region: FCD; pfam07729 1045855004719 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1045855004720 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1045855004721 iron-sulfur cluster [ion binding]; other site 1045855004722 [2Fe-2S] cluster binding site [ion binding]; other site 1045855004723 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1045855004724 beta subunit interface [polypeptide binding]; other site 1045855004725 alpha subunit interface [polypeptide binding]; other site 1045855004726 active site 1045855004727 substrate binding site [chemical binding]; other site 1045855004728 Fe binding site [ion binding]; other site 1045855004729 potential frameshift: common BLAST hit: gi|91781201|ref|YP_556408.1| biphenyl 2,3-dioxygenase small subunit (BphA2) 1045855004730 BphX-like; Region: BphX; pfam06139 1045855004731 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1045855004732 [2Fe-2S] cluster binding site [ion binding]; other site 1045855004733 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1045855004734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045855004735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045855004736 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase; Region: BphB_TodD; TIGR03325 1045855004737 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 1045855004738 NAD binding site [chemical binding]; other site 1045855004739 active site 1045855004740 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1045855004741 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1045855004742 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1045855004743 active site 1045855004744 Fe binding site [ion binding]; other site 1045855004745 glutathionine S-transferase; Provisional; Region: PRK10542 1045855004746 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1045855004747 C-terminal domain interface [polypeptide binding]; other site 1045855004748 GSH binding site (G-site) [chemical binding]; other site 1045855004749 dimer interface [polypeptide binding]; other site 1045855004750 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1045855004751 dimer interface [polypeptide binding]; other site 1045855004752 N-terminal domain interface [polypeptide binding]; other site 1045855004753 substrate binding pocket (H-site) [chemical binding]; other site 1045855004754 2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220 1045855004755 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1045855004756 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1045855004757 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1045855004758 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1045855004759 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1045855004760 active site 1045855004761 catalytic residues [active] 1045855004762 metal binding site [ion binding]; metal-binding site 1045855004763 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1045855004764 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1045855004765 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045855004766 acyl-activating enzyme (AAE) consensus motif; other site 1045855004767 AMP binding site [chemical binding]; other site 1045855004768 active site 1045855004769 CoA binding site [chemical binding]; other site 1045855004770 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1045855004771 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1045855004772 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 1045855004773 CrcB-like protein; Region: CRCB; cl09114 1045855004774 recombination factor protein RarA; Reviewed; Region: PRK13342 1045855004775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855004776 Walker A motif; other site 1045855004777 ATP binding site [chemical binding]; other site 1045855004778 Walker B motif; other site 1045855004779 arginine finger; other site 1045855004780 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1045855004781 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1045855004782 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1045855004783 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1045855004784 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1045855004785 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1045855004786 thioredoxin reductase; Provisional; Region: PRK10262 1045855004787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045855004788 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045855004789 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1045855004790 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1045855004791 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1045855004792 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1045855004793 rRNA binding site [nucleotide binding]; other site 1045855004794 predicted 30S ribosome binding site; other site 1045855004795 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1045855004796 Clp amino terminal domain; Region: Clp_N; pfam02861 1045855004797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855004798 Walker A motif; other site 1045855004799 ATP binding site [chemical binding]; other site 1045855004800 Walker B motif; other site 1045855004801 arginine finger; other site 1045855004802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855004803 Walker A motif; other site 1045855004804 ATP binding site [chemical binding]; other site 1045855004805 Walker B motif; other site 1045855004806 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1045855004807 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1045855004808 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1045855004809 nudix motif; other site 1045855004810 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1045855004811 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1045855004812 putative lysogenization regulator; Reviewed; Region: PRK00218 1045855004813 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1045855004814 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1045855004815 substrate binding site [chemical binding]; other site 1045855004816 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1045855004817 substrate binding site [chemical binding]; other site 1045855004818 ligand binding site [chemical binding]; other site 1045855004819 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 1045855004820 putative active site [active] 1045855004821 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1045855004822 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1045855004823 aconitate hydratase; Validated; Region: PRK09277 1045855004824 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1045855004825 substrate binding site [chemical binding]; other site 1045855004826 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1045855004827 ligand binding site [chemical binding]; other site 1045855004828 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1045855004829 substrate binding site [chemical binding]; other site 1045855004830 putative long-chain fatty acyl CoA ligase; Provisional; Region: PRK08751 1045855004831 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1045855004832 acyl-activating enzyme (AAE) consensus motif; other site 1045855004833 putative AMP binding site [chemical binding]; other site 1045855004834 putative active site [active] 1045855004835 putative CoA binding site [chemical binding]; other site 1045855004836 enoyl-CoA hydratase; Validated; Region: PRK08788 1045855004837 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045855004838 substrate binding site [chemical binding]; other site 1045855004839 oxyanion hole (OAH) forming residues; other site 1045855004840 trimer interface [polypeptide binding]; other site 1045855004841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855004842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855004843 dimer interface [polypeptide binding]; other site 1045855004844 phosphorylation site [posttranslational modification] 1045855004845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855004846 ATP binding site [chemical binding]; other site 1045855004847 Mg2+ binding site [ion binding]; other site 1045855004848 G-X-G motif; other site 1045855004849 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855004850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855004851 active site 1045855004852 phosphorylation site [posttranslational modification] 1045855004853 intermolecular recognition site; other site 1045855004854 dimerization interface [polypeptide binding]; other site 1045855004855 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1045855004856 putative binding surface; other site 1045855004857 active site 1045855004858 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1045855004859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855004860 active site 1045855004861 phosphorylation site [posttranslational modification] 1045855004862 intermolecular recognition site; other site 1045855004863 dimerization interface [polypeptide binding]; other site 1045855004864 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045855004865 Zn2+ binding site [ion binding]; other site 1045855004866 Mg2+ binding site [ion binding]; other site 1045855004867 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1045855004868 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1045855004869 dimer interface [polypeptide binding]; other site 1045855004870 putative anticodon binding site; other site 1045855004871 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1045855004872 motif 1; other site 1045855004873 active site 1045855004874 motif 2; other site 1045855004875 motif 3; other site 1045855004876 peptide chain release factor 2; Provisional; Region: PRK08787 1045855004877 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1045855004878 RF-1 domain; Region: RF-1; pfam00472 1045855004879 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855004880 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855004881 metal binding site [ion binding]; metal-binding site 1045855004882 active site 1045855004883 I-site; other site 1045855004884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1045855004885 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1045855004886 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1045855004887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1045855004888 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1045855004889 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1045855004890 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1045855004891 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1045855004892 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1045855004893 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1045855004894 Putative addiction module component; Region: Unstab_antitox; pfam09720 1045855004895 DNA methylase; Region: N6_N4_Mtase; cl17433 1045855004896 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1045855004897 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045855004898 Walker A/P-loop; other site 1045855004899 ATP binding site [chemical binding]; other site 1045855004900 Q-loop/lid; other site 1045855004901 ABC transporter signature motif; other site 1045855004902 Walker B; other site 1045855004903 D-loop; other site 1045855004904 H-loop/switch region; other site 1045855004905 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1045855004906 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045855004907 FtsX-like permease family; Region: FtsX; pfam02687 1045855004908 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1045855004909 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1045855004910 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1045855004911 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 1045855004912 L-aspartate oxidase; Provisional; Region: PRK06175 1045855004913 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1045855004914 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 1045855004915 putative SdhC subunit interface [polypeptide binding]; other site 1045855004916 putative proximal heme binding site [chemical binding]; other site 1045855004917 putative Iron-sulfur protein interface [polypeptide binding]; other site 1045855004918 putative proximal quinone binding site; other site 1045855004919 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1045855004920 Iron-sulfur protein interface; other site 1045855004921 proximal quinone binding site [chemical binding]; other site 1045855004922 SdhD (CybS) interface [polypeptide binding]; other site 1045855004923 proximal heme binding site [chemical binding]; other site 1045855004924 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 1045855004925 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 1045855004926 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1045855004927 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1045855004928 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1045855004929 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1045855004930 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1045855004931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1045855004932 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1045855004933 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1045855004934 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1045855004935 active site 1045855004936 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1045855004937 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1045855004938 putative ATP binding site [chemical binding]; other site 1045855004939 putative substrate interface [chemical binding]; other site 1045855004940 Cytochrome C' Region: Cytochrom_C_2; cl01610 1045855004941 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1045855004942 DNA-binding site [nucleotide binding]; DNA binding site 1045855004943 RNA-binding motif; other site 1045855004944 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1045855004945 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1045855004946 dimerization interface [polypeptide binding]; other site 1045855004947 substrate binding site [chemical binding]; other site 1045855004948 active site 1045855004949 calcium binding site [ion binding]; other site 1045855004950 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1045855004951 ArsC family; Region: ArsC; pfam03960 1045855004952 catalytic residues [active] 1045855004953 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1045855004954 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1045855004955 C-terminal domain interface [polypeptide binding]; other site 1045855004956 GSH binding site (G-site) [chemical binding]; other site 1045855004957 dimer interface [polypeptide binding]; other site 1045855004958 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1045855004959 N-terminal domain interface [polypeptide binding]; other site 1045855004960 dimer interface [polypeptide binding]; other site 1045855004961 substrate binding pocket (H-site) [chemical binding]; other site 1045855004962 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1045855004963 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1045855004964 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1045855004965 hypothetical protein; Provisional; Region: PRK11019 1045855004966 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1045855004967 Zn binding site [ion binding]; other site 1045855004968 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1045855004969 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 1045855004970 putative metal binding site [ion binding]; other site 1045855004971 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1045855004972 Interdomain contacts; other site 1045855004973 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1045855004974 ATP binding site [chemical binding]; other site 1045855004975 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1045855004976 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1045855004977 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1045855004978 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1045855004979 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1045855004980 NAD binding site [chemical binding]; other site 1045855004981 Phe binding site; other site 1045855004982 putative acyltransferase; Provisional; Region: PRK05790 1045855004983 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1045855004984 dimer interface [polypeptide binding]; other site 1045855004985 active site 1045855004986 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1045855004987 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1045855004988 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1045855004989 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1045855004990 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1045855004991 G1 box; other site 1045855004992 GTP/Mg2+ binding site [chemical binding]; other site 1045855004993 Switch I region; other site 1045855004994 G2 box; other site 1045855004995 G3 box; other site 1045855004996 Switch II region; other site 1045855004997 G4 box; other site 1045855004998 G5 box; other site 1045855004999 Nucleoside recognition; Region: Gate; pfam07670 1045855005000 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1045855005001 Nucleoside recognition; Region: Gate; pfam07670 1045855005002 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1045855005003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045855005004 Coenzyme A binding pocket [chemical binding]; other site 1045855005005 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1045855005006 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1045855005007 NAD binding site [chemical binding]; other site 1045855005008 homodimer interface [polypeptide binding]; other site 1045855005009 homotetramer interface [polypeptide binding]; other site 1045855005010 active site 1045855005011 elongation factor P; Provisional; Region: PRK04542 1045855005012 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1045855005013 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1045855005014 RNA binding site [nucleotide binding]; other site 1045855005015 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1045855005016 RNA binding site [nucleotide binding]; other site 1045855005017 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1045855005018 FAD binding domain; Region: FAD_binding_4; pfam01565 1045855005019 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1045855005020 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1045855005021 ligand binding site [chemical binding]; other site 1045855005022 NAD binding site [chemical binding]; other site 1045855005023 tetramer interface [polypeptide binding]; other site 1045855005024 catalytic site [active] 1045855005025 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1045855005026 L-serine binding site [chemical binding]; other site 1045855005027 ACT domain interface; other site 1045855005028 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1045855005029 nudix motif; other site 1045855005030 amino acid transporter; Region: 2A0306; TIGR00909 1045855005031 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1045855005032 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1045855005033 intersubunit interface [polypeptide binding]; other site 1045855005034 active site 1045855005035 Zn2+ binding site [ion binding]; other site 1045855005036 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1045855005037 Cupin domain; Region: Cupin_2; cl17218 1045855005038 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 1045855005039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1045855005040 motif II; other site 1045855005041 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1045855005042 active site 1045855005043 homotetramer interface [polypeptide binding]; other site 1045855005044 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1045855005045 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1045855005046 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1045855005047 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1045855005048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855005049 catalytic residue [active] 1045855005050 allantoate amidohydrolase; Reviewed; Region: PRK09290 1045855005051 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1045855005052 active site 1045855005053 metal binding site [ion binding]; metal-binding site 1045855005054 dimer interface [polypeptide binding]; other site 1045855005055 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1045855005056 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1045855005057 amidase; Provisional; Region: PRK09201 1045855005058 Amidase; Region: Amidase; cl11426 1045855005059 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1045855005060 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1045855005061 FMN-binding pocket [chemical binding]; other site 1045855005062 flavin binding motif; other site 1045855005063 phosphate binding motif [ion binding]; other site 1045855005064 beta-alpha-beta structure motif; other site 1045855005065 NAD binding pocket [chemical binding]; other site 1045855005066 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045855005067 catalytic loop [active] 1045855005068 iron binding site [ion binding]; other site 1045855005069 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1045855005070 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1045855005071 [2Fe-2S] cluster binding site [ion binding]; other site 1045855005072 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1045855005073 hydrophobic ligand binding site; other site 1045855005074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045855005075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855005076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045855005077 dimerization interface [polypeptide binding]; other site 1045855005078 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1045855005079 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1045855005080 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1045855005081 potential frameshift: common BLAST hit: gi|78060581|ref|YP_367156.1| LysR family transcriptional regulator 1045855005082 LysE type translocator; Region: LysE; cl00565 1045855005083 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1045855005084 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1045855005085 active site 1045855005086 catalytic site [active] 1045855005087 tetramer interface [polypeptide binding]; other site 1045855005088 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 1045855005089 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1045855005090 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1045855005091 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1045855005092 metal binding site [ion binding]; metal-binding site 1045855005093 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1045855005094 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1045855005095 substrate binding site [chemical binding]; other site 1045855005096 glutamase interaction surface [polypeptide binding]; other site 1045855005097 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1045855005098 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1045855005099 catalytic residues [active] 1045855005100 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1045855005101 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1045855005102 putative active site [active] 1045855005103 oxyanion strand; other site 1045855005104 catalytic triad [active] 1045855005105 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1045855005106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855005107 active site 1045855005108 motif I; other site 1045855005109 motif II; other site 1045855005110 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1045855005111 putative active site pocket [active] 1045855005112 4-fold oligomerization interface [polypeptide binding]; other site 1045855005113 metal binding residues [ion binding]; metal-binding site 1045855005114 3-fold/trimer interface [polypeptide binding]; other site 1045855005115 histidinol-phosphate aminotransferase; Provisional; Region: PRK04781 1045855005116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045855005117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855005118 homodimer interface [polypeptide binding]; other site 1045855005119 catalytic residue [active] 1045855005120 histidinol dehydrogenase; Region: hisD; TIGR00069 1045855005121 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1045855005122 NAD binding site [chemical binding]; other site 1045855005123 dimerization interface [polypeptide binding]; other site 1045855005124 product binding site; other site 1045855005125 substrate binding site [chemical binding]; other site 1045855005126 zinc binding site [ion binding]; other site 1045855005127 catalytic residues [active] 1045855005128 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1045855005129 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1045855005130 HisG, C-terminal domain; Region: HisG_C; cl06867 1045855005131 Trp repressor protein; Region: Trp_repressor; pfam01371 1045855005132 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 1045855005133 Domain interface; other site 1045855005134 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 1045855005135 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1045855005136 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1045855005137 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1045855005138 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1045855005139 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1045855005140 putative dimer interface [polypeptide binding]; other site 1045855005141 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1045855005142 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1045855005143 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045855005144 active site 1045855005145 potential frameshift: common BLAST hit: gi|120612020|ref|YP_971698.1| phage integrase family protein 1045855005146 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1045855005147 Part of AAA domain; Region: AAA_19; pfam13245 1045855005148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855005149 AAA domain; Region: AAA_21; pfam13304 1045855005150 Walker A/P-loop; other site 1045855005151 ATP binding site [chemical binding]; other site 1045855005152 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1045855005153 active site 1045855005154 metal binding site [ion binding]; metal-binding site 1045855005155 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 1045855005156 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1045855005157 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1045855005158 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1045855005159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855005160 AAA domain; Region: AAA_21; pfam13304 1045855005161 Walker A/P-loop; other site 1045855005162 ATP binding site [chemical binding]; other site 1045855005163 AAA domain; Region: AAA_21; pfam13304 1045855005164 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1045855005165 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1045855005166 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1045855005167 ParB-like nuclease domain; Region: ParBc; pfam02195 1045855005168 Uncharacterized conserved protein [Function unknown]; Region: COG5489 1045855005169 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1045855005170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045855005171 non-specific DNA binding site [nucleotide binding]; other site 1045855005172 salt bridge; other site 1045855005173 sequence-specific DNA binding site [nucleotide binding]; other site 1045855005174 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 1045855005175 Uncharacterized conserved protein [Function unknown]; Region: COG5419 1045855005176 Helix-turn-helix domain; Region: HTH_17; cl17695 1045855005177 Replication initiator protein A; Region: RPA; cl17860 1045855005178 ParA-like protein; Provisional; Region: PHA02518 1045855005179 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1045855005180 P-loop; other site 1045855005181 Magnesium ion binding site [ion binding]; other site 1045855005182 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 1045855005183 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1045855005184 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 1045855005185 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 1045855005186 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 1045855005187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045855005188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855005189 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1045855005190 putative effector binding pocket; other site 1045855005191 dimerization interface [polypeptide binding]; other site 1045855005192 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1045855005193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855005194 Integrase core domain; Region: rve; pfam00665 1045855005195 Integrase core domain; Region: rve_3; pfam13683 1045855005196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045855005197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855005198 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1045855005199 dimerization interface [polypeptide binding]; other site 1045855005200 substrate binding pocket [chemical binding]; other site 1045855005201 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 1045855005202 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1045855005203 Walker A motif; other site 1045855005204 ATP binding site [chemical binding]; other site 1045855005205 Walker B motif; other site 1045855005206 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1045855005207 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1045855005208 ATP binding site [chemical binding]; other site 1045855005209 Walker A motif; other site 1045855005210 hexamer interface [polypeptide binding]; other site 1045855005211 Walker B motif; other site 1045855005212 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1045855005213 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 1045855005214 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 1045855005215 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1045855005216 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1045855005217 Walker A motif; other site 1045855005218 ATP binding site [chemical binding]; other site 1045855005219 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1045855005220 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 1045855005221 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 1045855005222 conjugal transfer protein TrbL; Provisional; Region: PRK13875 1045855005223 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 1045855005224 conjugal transfer protein TrbF; Provisional; Region: PRK13872 1045855005225 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1045855005226 VirB7 interaction site; other site 1045855005227 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 1045855005228 Uncharacterized conserved small protein [Function unknown]; Region: COG5639 1045855005229 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 1045855005230 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1045855005231 integrase; Provisional; Region: PRK09692 1045855005232 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1045855005233 active site 1045855005234 Int/Topo IB signature motif; other site 1045855005235 GMP synthase; Reviewed; Region: guaA; PRK00074 1045855005236 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1045855005237 AMP/PPi binding site [chemical binding]; other site 1045855005238 candidate oxyanion hole; other site 1045855005239 catalytic triad [active] 1045855005240 potential glutamine specificity residues [chemical binding]; other site 1045855005241 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1045855005242 ATP Binding subdomain [chemical binding]; other site 1045855005243 Ligand Binding sites [chemical binding]; other site 1045855005244 Dimerization subdomain; other site 1045855005245 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1045855005246 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1045855005247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1045855005248 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1045855005249 active site 1045855005250 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1045855005251 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1045855005252 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1045855005253 homodimer interface [polypeptide binding]; other site 1045855005254 NADP binding site [chemical binding]; other site 1045855005255 substrate binding site [chemical binding]; other site 1045855005256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1045855005257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1045855005258 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1045855005259 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1045855005260 TrkA-N domain; Region: TrkA_N; pfam02254 1045855005261 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 1045855005262 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1045855005263 active site residue [active] 1045855005264 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1045855005265 ATP binding site [chemical binding]; other site 1045855005266 substrate interface [chemical binding]; other site 1045855005267 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1045855005268 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1045855005269 dimer interface [polypeptide binding]; other site 1045855005270 putative functional site; other site 1045855005271 putative MPT binding site; other site 1045855005272 GTP-binding protein Der; Reviewed; Region: PRK00093 1045855005273 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1045855005274 G1 box; other site 1045855005275 GTP/Mg2+ binding site [chemical binding]; other site 1045855005276 Switch I region; other site 1045855005277 G2 box; other site 1045855005278 Switch II region; other site 1045855005279 G3 box; other site 1045855005280 G4 box; other site 1045855005281 G5 box; other site 1045855005282 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1045855005283 G1 box; other site 1045855005284 GTP/Mg2+ binding site [chemical binding]; other site 1045855005285 Switch I region; other site 1045855005286 G2 box; other site 1045855005287 G3 box; other site 1045855005288 Switch II region; other site 1045855005289 G4 box; other site 1045855005290 G5 box; other site 1045855005291 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1045855005292 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1045855005293 Trp docking motif [polypeptide binding]; other site 1045855005294 active site 1045855005295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1045855005296 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1045855005297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045855005298 non-specific DNA binding site [nucleotide binding]; other site 1045855005299 salt bridge; other site 1045855005300 sequence-specific DNA binding site [nucleotide binding]; other site 1045855005301 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1045855005302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855005303 binding surface 1045855005304 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045855005305 TPR motif; other site 1045855005306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855005307 TPR motif; other site 1045855005308 binding surface 1045855005309 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1045855005310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045855005311 FeS/SAM binding site; other site 1045855005312 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1045855005313 active site 1045855005314 multimer interface [polypeptide binding]; other site 1045855005315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045855005316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855005317 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1045855005318 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1045855005319 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1045855005320 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1045855005321 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1045855005322 dimer interface [polypeptide binding]; other site 1045855005323 active site 1045855005324 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1045855005325 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1045855005326 active site 1045855005327 tetramer interface; other site 1045855005328 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1045855005329 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1045855005330 NAD(P) binding site [chemical binding]; other site 1045855005331 homodimer interface [polypeptide binding]; other site 1045855005332 substrate binding site [chemical binding]; other site 1045855005333 active site 1045855005334 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1045855005335 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1045855005336 Mg++ binding site [ion binding]; other site 1045855005337 putative catalytic motif [active] 1045855005338 putative substrate binding site [chemical binding]; other site 1045855005339 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1045855005340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855005341 binding surface 1045855005342 TPR motif; other site 1045855005343 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1045855005344 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1045855005345 IHF dimer interface [polypeptide binding]; other site 1045855005346 IHF - DNA interface [nucleotide binding]; other site 1045855005347 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1045855005348 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1045855005349 RNA binding site [nucleotide binding]; other site 1045855005350 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1045855005351 RNA binding site [nucleotide binding]; other site 1045855005352 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1045855005353 RNA binding site [nucleotide binding]; other site 1045855005354 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1045855005355 RNA binding site [nucleotide binding]; other site 1045855005356 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1045855005357 RNA binding site [nucleotide binding]; other site 1045855005358 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1045855005359 RNA binding site [nucleotide binding]; other site 1045855005360 cytidylate kinase; Provisional; Region: cmk; PRK00023 1045855005361 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1045855005362 CMP-binding site; other site 1045855005363 The sites determining sugar specificity; other site 1045855005364 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1045855005365 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1045855005366 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1045855005367 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1045855005368 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1045855005369 putative active site; other site 1045855005370 catalytic triad [active] 1045855005371 putative dimer interface [polypeptide binding]; other site 1045855005372 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 1045855005373 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1045855005374 Cytochrome c; Region: Cytochrom_C; cl11414 1045855005375 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1045855005376 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1045855005377 NifU-like domain; Region: NifU; cl00484 1045855005378 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1045855005379 aromatic arch; other site 1045855005380 DCoH dimer interaction site [polypeptide binding]; other site 1045855005381 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1045855005382 DCoH tetramer interaction site [polypeptide binding]; other site 1045855005383 substrate binding site [chemical binding]; other site 1045855005384 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1045855005385 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1045855005386 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1045855005387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045855005388 RNA binding surface [nucleotide binding]; other site 1045855005389 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1045855005390 active site 1045855005391 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1045855005392 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1045855005393 homodimer interface [polypeptide binding]; other site 1045855005394 oligonucleotide binding site [chemical binding]; other site 1045855005395 response regulator; Provisional; Region: PRK09483 1045855005396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855005397 active site 1045855005398 phosphorylation site [posttranslational modification] 1045855005399 intermolecular recognition site; other site 1045855005400 dimerization interface [polypeptide binding]; other site 1045855005401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045855005402 DNA binding residues [nucleotide binding] 1045855005403 dimerization interface [polypeptide binding]; other site 1045855005404 Predicted membrane protein [Function unknown]; Region: COG2323 1045855005405 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855005406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855005407 active site 1045855005408 phosphorylation site [posttranslational modification] 1045855005409 intermolecular recognition site; other site 1045855005410 dimerization interface [polypeptide binding]; other site 1045855005411 GAF domain; Region: GAF_2; pfam13185 1045855005412 GAF domain; Region: GAF_3; pfam13492 1045855005413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855005414 dimer interface [polypeptide binding]; other site 1045855005415 phosphorylation site [posttranslational modification] 1045855005416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855005417 ATP binding site [chemical binding]; other site 1045855005418 Mg2+ binding site [ion binding]; other site 1045855005419 G-X-G motif; other site 1045855005420 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855005421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855005422 active site 1045855005423 phosphorylation site [posttranslational modification] 1045855005424 intermolecular recognition site; other site 1045855005425 dimerization interface [polypeptide binding]; other site 1045855005426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855005427 active site 1045855005428 phosphorylation site [posttranslational modification] 1045855005429 intermolecular recognition site; other site 1045855005430 dimerization interface [polypeptide binding]; other site 1045855005431 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855005432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855005433 active site 1045855005434 phosphorylation site [posttranslational modification] 1045855005435 intermolecular recognition site; other site 1045855005436 dimerization interface [polypeptide binding]; other site 1045855005437 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1045855005438 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1045855005439 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1045855005440 CheB methylesterase; Region: CheB_methylest; pfam01339 1045855005441 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855005442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855005443 active site 1045855005444 phosphorylation site [posttranslational modification] 1045855005445 intermolecular recognition site; other site 1045855005446 dimerization interface [polypeptide binding]; other site 1045855005447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855005448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855005449 dimer interface [polypeptide binding]; other site 1045855005450 phosphorylation site [posttranslational modification] 1045855005451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855005452 ATP binding site [chemical binding]; other site 1045855005453 Mg2+ binding site [ion binding]; other site 1045855005454 G-X-G motif; other site 1045855005455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045855005456 active site 1045855005457 Putative glucoamylase; Region: Glycoamylase; pfam10091 1045855005458 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1045855005459 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1045855005460 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1045855005461 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1045855005462 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1045855005463 active site 1045855005464 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1045855005465 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1045855005466 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1045855005467 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1045855005468 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1045855005469 generic binding surface II; other site 1045855005470 generic binding surface I; other site 1045855005471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045855005472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855005473 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1045855005474 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1045855005475 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 1045855005476 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1045855005477 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1045855005478 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1045855005479 putative active site [active] 1045855005480 nucleotide binding site [chemical binding]; other site 1045855005481 nudix motif; other site 1045855005482 putative metal binding site [ion binding]; other site 1045855005483 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1045855005484 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1045855005485 RNase E interface [polypeptide binding]; other site 1045855005486 trimer interface [polypeptide binding]; other site 1045855005487 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1045855005488 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1045855005489 RNase E interface [polypeptide binding]; other site 1045855005490 trimer interface [polypeptide binding]; other site 1045855005491 active site 1045855005492 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1045855005493 putative nucleic acid binding region [nucleotide binding]; other site 1045855005494 G-X-X-G motif; other site 1045855005495 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1045855005496 RNA binding site [nucleotide binding]; other site 1045855005497 domain interface; other site 1045855005498 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1045855005499 16S/18S rRNA binding site [nucleotide binding]; other site 1045855005500 S13e-L30e interaction site [polypeptide binding]; other site 1045855005501 25S rRNA binding site [nucleotide binding]; other site 1045855005502 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04642 1045855005503 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1045855005504 RNA binding site [nucleotide binding]; other site 1045855005505 active site 1045855005506 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1045855005507 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1045855005508 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1045855005509 translation initiation factor IF-2; Region: IF-2; TIGR00487 1045855005510 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1045855005511 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1045855005512 G1 box; other site 1045855005513 putative GEF interaction site [polypeptide binding]; other site 1045855005514 GTP/Mg2+ binding site [chemical binding]; other site 1045855005515 Switch I region; other site 1045855005516 G2 box; other site 1045855005517 G3 box; other site 1045855005518 Switch II region; other site 1045855005519 G4 box; other site 1045855005520 G5 box; other site 1045855005521 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1045855005522 Translation-initiation factor 2; Region: IF-2; pfam11987 1045855005523 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1045855005524 NusA N-terminal domain; Region: NusA_N; pfam08529 1045855005525 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1045855005526 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1045855005527 RNA binding site [nucleotide binding]; other site 1045855005528 homodimer interface [polypeptide binding]; other site 1045855005529 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1045855005530 G-X-X-G motif; other site 1045855005531 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1045855005532 G-X-X-G motif; other site 1045855005533 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1045855005534 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1045855005535 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1045855005536 Sm and related proteins; Region: Sm_like; cl00259 1045855005537 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1045855005538 putative oligomer interface [polypeptide binding]; other site 1045855005539 putative RNA binding site [nucleotide binding]; other site 1045855005540 FtsH Extracellular; Region: FtsH_ext; pfam06480 1045855005541 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1045855005542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855005543 Walker A motif; other site 1045855005544 ATP binding site [chemical binding]; other site 1045855005545 Walker B motif; other site 1045855005546 arginine finger; other site 1045855005547 Peptidase family M41; Region: Peptidase_M41; pfam01434 1045855005548 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1045855005549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855005550 S-adenosylmethionine binding site [chemical binding]; other site 1045855005551 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1045855005552 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 1045855005553 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045855005554 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1045855005555 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045855005556 Predicted membrane protein [Function unknown]; Region: COG1238 1045855005557 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1045855005558 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1045855005559 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1045855005560 Smr domain; Region: Smr; pfam01713 1045855005561 sensor protein QseC; Provisional; Region: PRK10337 1045855005562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855005563 dimer interface [polypeptide binding]; other site 1045855005564 phosphorylation site [posttranslational modification] 1045855005565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855005566 ATP binding site [chemical binding]; other site 1045855005567 Mg2+ binding site [ion binding]; other site 1045855005568 G-X-G motif; other site 1045855005569 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045855005570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855005571 active site 1045855005572 phosphorylation site [posttranslational modification] 1045855005573 intermolecular recognition site; other site 1045855005574 dimerization interface [polypeptide binding]; other site 1045855005575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855005576 DNA binding site [nucleotide binding] 1045855005577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855005578 TPR motif; other site 1045855005579 binding surface 1045855005580 short chain dehydrogenase; Provisional; Region: PRK09072 1045855005581 classical (c) SDRs; Region: SDR_c; cd05233 1045855005582 NAD(P) binding site [chemical binding]; other site 1045855005583 active site 1045855005584 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1045855005585 heme binding pocket [chemical binding]; other site 1045855005586 heme ligand [chemical binding]; other site 1045855005587 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914 1045855005588 AMP-binding enzyme; Region: AMP-binding; pfam00501 1045855005589 acyl-activating enzyme (AAE) consensus motif; other site 1045855005590 putative AMP binding site [chemical binding]; other site 1045855005591 putative active site [active] 1045855005592 putative CoA binding site [chemical binding]; other site 1045855005593 Thermostable hemolysin; Region: T_hemolysin; pfam12261 1045855005594 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1045855005595 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1045855005596 Permutation of conserved domain; other site 1045855005597 active site 1045855005598 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1045855005599 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1045855005600 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1045855005601 substrate binding site; other site 1045855005602 dimer interface; other site 1045855005603 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1045855005604 homotrimer interaction site [polypeptide binding]; other site 1045855005605 zinc binding site [ion binding]; other site 1045855005606 CDP-binding sites; other site 1045855005607 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1045855005608 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1045855005609 enolase; Provisional; Region: eno; PRK00077 1045855005610 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1045855005611 dimer interface [polypeptide binding]; other site 1045855005612 metal binding site [ion binding]; metal-binding site 1045855005613 substrate binding pocket [chemical binding]; other site 1045855005614 CTP synthetase; Validated; Region: pyrG; PRK05380 1045855005615 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1045855005616 Catalytic site [active] 1045855005617 active site 1045855005618 UTP binding site [chemical binding]; other site 1045855005619 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1045855005620 active site 1045855005621 putative oxyanion hole; other site 1045855005622 catalytic triad [active] 1045855005623 Glucokinase; Region: Glucokinase; cl17310 1045855005624 glucokinase, proteobacterial type; Region: glk; TIGR00749 1045855005625 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1045855005626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855005627 Mg2+ binding site [ion binding]; other site 1045855005628 G-X-G motif; other site 1045855005629 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1045855005630 anchoring element; other site 1045855005631 dimer interface [polypeptide binding]; other site 1045855005632 ATP binding site [chemical binding]; other site 1045855005633 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1045855005634 active site 1045855005635 metal binding site [ion binding]; metal-binding site 1045855005636 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1045855005637 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1045855005638 putative nucleotide binding site [chemical binding]; other site 1045855005639 uridine monophosphate binding site [chemical binding]; other site 1045855005640 homohexameric interface [polypeptide binding]; other site 1045855005641 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1045855005642 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1045855005643 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1045855005644 hinge region; other site 1045855005645 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1045855005646 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1045855005647 catalytic residue [active] 1045855005648 putative FPP diphosphate binding site; other site 1045855005649 putative FPP binding hydrophobic cleft; other site 1045855005650 dimer interface [polypeptide binding]; other site 1045855005651 putative IPP diphosphate binding site; other site 1045855005652 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1045855005653 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1045855005654 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1045855005655 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1045855005656 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1045855005657 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1045855005658 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1045855005659 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1045855005660 active site 1045855005661 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1045855005662 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1045855005663 protein binding site [polypeptide binding]; other site 1045855005664 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1045855005665 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1045855005666 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045855005667 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045855005668 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045855005669 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045855005670 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045855005671 Surface antigen; Region: Bac_surface_Ag; pfam01103 1045855005672 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1045855005673 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1045855005674 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1045855005675 trimer interface [polypeptide binding]; other site 1045855005676 active site 1045855005677 UDP-GlcNAc binding site [chemical binding]; other site 1045855005678 lipid binding site [chemical binding]; lipid-binding site 1045855005679 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1045855005680 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1045855005681 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1045855005682 active site 1045855005683 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1045855005684 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1045855005685 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1045855005686 RNA/DNA hybrid binding site [nucleotide binding]; other site 1045855005687 active site 1045855005688 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1045855005689 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1045855005690 putative active site [active] 1045855005691 putative PHP Thumb interface [polypeptide binding]; other site 1045855005692 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1045855005693 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1045855005694 generic binding surface II; other site 1045855005695 generic binding surface I; other site 1045855005696 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1045855005697 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1045855005698 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1045855005699 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1045855005700 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1045855005701 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1045855005702 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1045855005703 Subunit I/III interface [polypeptide binding]; other site 1045855005704 Subunit III/IV interface [polypeptide binding]; other site 1045855005705 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1045855005706 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1045855005707 D-pathway; other site 1045855005708 Putative ubiquinol binding site [chemical binding]; other site 1045855005709 Low-spin heme (heme b) binding site [chemical binding]; other site 1045855005710 Putative water exit pathway; other site 1045855005711 Binuclear center (heme o3/CuB) [ion binding]; other site 1045855005712 K-pathway; other site 1045855005713 Putative proton exit pathway; other site 1045855005714 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1045855005715 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1045855005716 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1045855005717 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1045855005718 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1045855005719 NAD binding site [chemical binding]; other site 1045855005720 catalytic Zn binding site [ion binding]; other site 1045855005721 structural Zn binding site [ion binding]; other site 1045855005722 Hemerythrin-like domain; Region: Hr-like; cd12108 1045855005723 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1045855005724 dimanganese center [ion binding]; other site 1045855005725 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1045855005726 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1045855005727 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1045855005728 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1045855005729 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045855005730 active site 1045855005731 HIGH motif; other site 1045855005732 nucleotide binding site [chemical binding]; other site 1045855005733 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1045855005734 active site 1045855005735 KMSKS motif; other site 1045855005736 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1045855005737 tRNA binding surface [nucleotide binding]; other site 1045855005738 anticodon binding site; other site 1045855005739 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1045855005740 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1045855005741 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1045855005742 active site 1045855005743 Riboflavin kinase; Region: Flavokinase; smart00904 1045855005744 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1045855005745 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1045855005746 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1045855005747 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1045855005748 GTP1/OBG; Region: GTP1_OBG; pfam01018 1045855005749 Obg GTPase; Region: Obg; cd01898 1045855005750 G1 box; other site 1045855005751 GTP/Mg2+ binding site [chemical binding]; other site 1045855005752 Switch I region; other site 1045855005753 G2 box; other site 1045855005754 G3 box; other site 1045855005755 Switch II region; other site 1045855005756 G4 box; other site 1045855005757 G5 box; other site 1045855005758 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1045855005759 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1045855005760 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1045855005761 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1045855005762 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1045855005763 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1045855005764 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1045855005765 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1045855005766 active site 1045855005767 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1045855005768 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045855005769 substrate binding site [chemical binding]; other site 1045855005770 oxyanion hole (OAH) forming residues; other site 1045855005771 trimer interface [polypeptide binding]; other site 1045855005772 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1045855005773 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1045855005774 active site residue [active] 1045855005775 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1045855005776 active site residue [active] 1045855005777 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1045855005778 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1045855005779 putative active site [active] 1045855005780 putative CoA binding site [chemical binding]; other site 1045855005781 nudix motif; other site 1045855005782 metal binding site [ion binding]; metal-binding site 1045855005783 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1045855005784 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1045855005785 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045855005786 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1045855005787 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045855005788 substrate binding site [chemical binding]; other site 1045855005789 oxyanion hole (OAH) forming residues; other site 1045855005790 trimer interface [polypeptide binding]; other site 1045855005791 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1045855005792 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1045855005793 minor groove reading motif; other site 1045855005794 helix-hairpin-helix signature motif; other site 1045855005795 substrate binding pocket [chemical binding]; other site 1045855005796 active site 1045855005797 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1045855005798 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045855005799 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045855005800 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1045855005801 arsenical-resistance protein; Region: acr3; TIGR00832 1045855005802 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1045855005803 ArsC family; Region: ArsC; pfam03960 1045855005804 catalytic residues [active] 1045855005805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045855005806 dimerization interface [polypeptide binding]; other site 1045855005807 putative DNA binding site [nucleotide binding]; other site 1045855005808 putative Zn2+ binding site [ion binding]; other site 1045855005809 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1045855005810 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855005811 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855005812 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1045855005813 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045855005814 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1045855005815 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045855005816 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045855005817 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1045855005818 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1045855005819 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1045855005820 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1045855005821 Walker A motif; other site 1045855005822 ATP binding site [chemical binding]; other site 1045855005823 Walker B motif; other site 1045855005824 type II secretion system protein F; Region: GspF; TIGR02120 1045855005825 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1045855005826 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1045855005827 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1045855005828 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1045855005829 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1045855005830 type II secretion system protein I; Region: gspI; TIGR01707 1045855005831 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1045855005832 type II secretion system protein J; Region: gspJ; TIGR01711 1045855005833 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1045855005834 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1045855005835 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1045855005836 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1045855005837 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 1045855005838 PBP superfamily domain; Region: PBP_like_2; cl17296 1045855005839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855005840 dimer interface [polypeptide binding]; other site 1045855005841 conserved gate region; other site 1045855005842 putative PBP binding loops; other site 1045855005843 ABC-ATPase subunit interface; other site 1045855005844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855005845 dimer interface [polypeptide binding]; other site 1045855005846 conserved gate region; other site 1045855005847 putative PBP binding loops; other site 1045855005848 ABC-ATPase subunit interface; other site 1045855005849 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1045855005850 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1045855005851 Walker A/P-loop; other site 1045855005852 ATP binding site [chemical binding]; other site 1045855005853 Q-loop/lid; other site 1045855005854 ABC transporter signature motif; other site 1045855005855 Walker B; other site 1045855005856 D-loop; other site 1045855005857 H-loop/switch region; other site 1045855005858 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1045855005859 PhoU domain; Region: PhoU; pfam01895 1045855005860 PhoU domain; Region: PhoU; pfam01895 1045855005861 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1045855005862 ribonuclease T; Provisional; Region: PRK05168 1045855005863 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1045855005864 active site 1045855005865 catalytic site [active] 1045855005866 substrate binding site [chemical binding]; other site 1045855005867 acyl-CoA synthetase; Validated; Region: PRK08316 1045855005868 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045855005869 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1045855005870 acyl-activating enzyme (AAE) consensus motif; other site 1045855005871 acyl-activating enzyme (AAE) consensus motif; other site 1045855005872 putative AMP binding site [chemical binding]; other site 1045855005873 putative active site [active] 1045855005874 putative CoA binding site [chemical binding]; other site 1045855005875 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1045855005876 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1045855005877 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1045855005878 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1045855005879 ribonuclease R; Region: RNase_R; TIGR02063 1045855005880 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1045855005881 RNB domain; Region: RNB; pfam00773 1045855005882 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1045855005883 RNA binding site [nucleotide binding]; other site 1045855005884 Integrase core domain; Region: rve_3; cl15866 1045855005885 Homeodomain-like domain; Region: HTH_23; pfam13384 1045855005886 Winged helix-turn helix; Region: HTH_29; pfam13551 1045855005887 Homeodomain-like domain; Region: HTH_32; pfam13565 1045855005888 PemK-like protein; Region: PemK; pfam02452 1045855005889 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1045855005890 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1045855005891 transmembrane helices; other site 1045855005892 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1045855005893 TrkA-C domain; Region: TrkA_C; pfam02080 1045855005894 TrkA-C domain; Region: TrkA_C; pfam02080 1045855005895 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1045855005896 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1045855005897 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1045855005898 CAP-like domain; other site 1045855005899 active site 1045855005900 primary dimer interface [polypeptide binding]; other site 1045855005901 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 1045855005902 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1045855005903 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1045855005904 active site 1045855005905 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855005906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855005907 active site 1045855005908 phosphorylation site [posttranslational modification] 1045855005909 intermolecular recognition site; other site 1045855005910 dimerization interface [polypeptide binding]; other site 1045855005911 Right handed beta helix region; Region: Beta_helix; pfam13229 1045855005912 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1045855005913 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1045855005914 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1045855005915 active site 1045855005916 dimer interface [polypeptide binding]; other site 1045855005917 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1045855005918 Ligand Binding Site [chemical binding]; other site 1045855005919 Molecular Tunnel; other site 1045855005920 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1045855005921 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1045855005922 metal binding site [ion binding]; metal-binding site 1045855005923 dimer interface [polypeptide binding]; other site 1045855005924 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1045855005925 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1045855005926 ArsC family; Region: ArsC; pfam03960 1045855005927 putative catalytic residues [active] 1045855005928 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1045855005929 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1045855005930 active site 1045855005931 substrate binding site [chemical binding]; other site 1045855005932 trimer interface [polypeptide binding]; other site 1045855005933 CoA binding site [chemical binding]; other site 1045855005934 PII uridylyl-transferase; Provisional; Region: PRK04374 1045855005935 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1045855005936 metal binding triad; other site 1045855005937 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1045855005938 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045855005939 Zn2+ binding site [ion binding]; other site 1045855005940 Mg2+ binding site [ion binding]; other site 1045855005941 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1045855005942 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1045855005943 methionine aminopeptidase; Provisional; Region: PRK08671 1045855005944 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1045855005945 active site 1045855005946 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1045855005947 rRNA interaction site [nucleotide binding]; other site 1045855005948 S8 interaction site; other site 1045855005949 putative laminin-1 binding site; other site 1045855005950 elongation factor Ts; Provisional; Region: tsf; PRK09377 1045855005951 UBA/TS-N domain; Region: UBA; pfam00627 1045855005952 Elongation factor TS; Region: EF_TS; pfam00889 1045855005953 Elongation factor TS; Region: EF_TS; pfam00889 1045855005954 Transposase IS200 like; Region: Y1_Tnp; cl00848 1045855005955 DNA repair protein RadA; Provisional; Region: PRK11823 1045855005956 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1045855005957 Walker A motif; other site 1045855005958 ATP binding site [chemical binding]; other site 1045855005959 Walker B motif; other site 1045855005960 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1045855005961 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045855005962 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045855005963 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1045855005964 Ligand Binding Site [chemical binding]; other site 1045855005965 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1045855005966 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1045855005967 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1045855005968 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1045855005969 substrate binding pocket [chemical binding]; other site 1045855005970 chain length determination region; other site 1045855005971 substrate-Mg2+ binding site; other site 1045855005972 catalytic residues [active] 1045855005973 aspartate-rich region 1; other site 1045855005974 active site lid residues [active] 1045855005975 aspartate-rich region 2; other site 1045855005976 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1045855005977 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 1045855005978 putative ligand binding site [chemical binding]; other site 1045855005979 NAD binding site [chemical binding]; other site 1045855005980 dimer interface [polypeptide binding]; other site 1045855005981 putative catalytic site [active] 1045855005982 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1045855005983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1045855005984 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1045855005985 Tic20-like protein; Region: Tic20; pfam09685 1045855005986 peptidase PmbA; Provisional; Region: PRK11040 1045855005987 hypothetical protein; Provisional; Region: PRK05255 1045855005988 protease TldD; Provisional; Region: tldD; PRK10735 1045855005989 TIGR02099 family protein; Region: TIGR02099 1045855005990 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1045855005991 ribonuclease G; Provisional; Region: PRK11712 1045855005992 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1045855005993 homodimer interface [polypeptide binding]; other site 1045855005994 oligonucleotide binding site [chemical binding]; other site 1045855005995 Maf-like protein; Region: Maf; pfam02545 1045855005996 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1045855005997 active site 1045855005998 dimer interface [polypeptide binding]; other site 1045855005999 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1045855006000 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1045855006001 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1045855006002 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855006003 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855006004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045855006005 TPR motif; other site 1045855006006 binding surface 1045855006007 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1045855006008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855006009 TPR motif; other site 1045855006010 TPR repeat; Region: TPR_11; pfam13414 1045855006011 binding surface 1045855006012 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1045855006013 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 1045855006014 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1045855006015 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1045855006016 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1045855006017 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1045855006018 active site 1045855006019 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1045855006020 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1045855006021 Lipopolysaccharide-assembly; Region: LptE; cl01125 1045855006022 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1045855006023 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1045855006024 HIGH motif; other site 1045855006025 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1045855006026 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045855006027 active site 1045855006028 KMSKS motif; other site 1045855006029 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1045855006030 tRNA binding surface [nucleotide binding]; other site 1045855006031 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1045855006032 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1045855006033 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1045855006034 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1045855006035 proposed catalytic triad [active] 1045855006036 active site nucleophile [active] 1045855006037 cyanophycin synthetase; Provisional; Region: PRK14016 1045855006038 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045855006039 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045855006040 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045855006041 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045855006042 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045855006043 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045855006044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855006045 S-adenosylmethionine binding site [chemical binding]; other site 1045855006046 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1045855006047 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1045855006048 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1045855006049 quinone interaction residues [chemical binding]; other site 1045855006050 active site 1045855006051 catalytic residues [active] 1045855006052 FMN binding site [chemical binding]; other site 1045855006053 substrate binding site [chemical binding]; other site 1045855006054 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1045855006055 FAD binding domain; Region: FAD_binding_4; pfam01565 1045855006056 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1045855006057 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1045855006058 EamA-like transporter family; Region: EamA; pfam00892 1045855006059 EamA-like transporter family; Region: EamA; cl17759 1045855006060 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1045855006061 aspartate racemase; Region: asp_race; TIGR00035 1045855006062 Protein of unknown function DUF45; Region: DUF45; pfam01863 1045855006063 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1045855006064 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1045855006065 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1045855006066 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045855006067 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855006068 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1045855006069 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1045855006070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045855006071 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 1045855006072 Walker A/P-loop; other site 1045855006073 ATP binding site [chemical binding]; other site 1045855006074 Q-loop/lid; other site 1045855006075 ABC transporter signature motif; other site 1045855006076 Walker B; other site 1045855006077 D-loop; other site 1045855006078 H-loop/switch region; other site 1045855006079 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1045855006080 aspartate racemase; Region: asp_race; TIGR00035 1045855006081 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1045855006082 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1045855006083 Phage-related protein [Function unknown]; Region: COG4695 1045855006084 Phage portal protein; Region: Phage_portal; pfam04860 1045855006085 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1045855006086 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1045855006087 Phage capsid family; Region: Phage_capsid; pfam05065 1045855006088 AAA domain; Region: AAA_25; pfam13481 1045855006089 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1045855006090 Walker A motif; other site 1045855006091 ATP binding site [chemical binding]; other site 1045855006092 Walker B motif; other site 1045855006093 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1045855006094 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1045855006095 active site 1045855006096 DNA binding site [nucleotide binding] 1045855006097 Int/Topo IB signature motif; other site 1045855006098 von Willebrand factor; Region: vWF_A; pfam12450 1045855006099 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1045855006100 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1045855006101 metal ion-dependent adhesion site (MIDAS); other site 1045855006102 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1045855006103 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045855006104 GAF domain; Region: GAF; pfam01590 1045855006105 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045855006106 GAF domain; Region: GAF_3; pfam13492 1045855006107 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855006108 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855006109 metal binding site [ion binding]; metal-binding site 1045855006110 active site 1045855006111 I-site; other site 1045855006112 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045855006113 RNA polymerase sigma factor; Provisional; Region: PRK12513 1045855006114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045855006115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045855006116 DNA binding residues [nucleotide binding] 1045855006117 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1045855006118 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1045855006119 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1045855006120 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1045855006121 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045855006122 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1045855006123 Walker A/P-loop; other site 1045855006124 ATP binding site [chemical binding]; other site 1045855006125 Q-loop/lid; other site 1045855006126 ABC transporter signature motif; other site 1045855006127 Walker B; other site 1045855006128 D-loop; other site 1045855006129 H-loop/switch region; other site 1045855006130 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 1045855006131 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1045855006132 Active_site [active] 1045855006133 Pirin-related protein [General function prediction only]; Region: COG1741 1045855006134 Pirin; Region: Pirin; pfam02678 1045855006135 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1045855006136 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1045855006137 DNA-binding site [nucleotide binding]; DNA binding site 1045855006138 RNA-binding motif; other site 1045855006139 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 1045855006140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045855006141 active site 1045855006142 beta-hexosaminidase; Provisional; Region: PRK05337 1045855006143 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1045855006144 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1045855006145 putative active site [active] 1045855006146 putative metal binding residues [ion binding]; other site 1045855006147 signature motif; other site 1045855006148 putative dimer interface [polypeptide binding]; other site 1045855006149 putative phosphate binding site [ion binding]; other site 1045855006150 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1045855006151 TRAM domain; Region: TRAM; cl01282 1045855006152 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045855006153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855006154 active site 1045855006155 phosphorylation site [posttranslational modification] 1045855006156 intermolecular recognition site; other site 1045855006157 dimerization interface [polypeptide binding]; other site 1045855006158 Recombination protein O N terminal; Region: RecO_N; pfam11967 1045855006159 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1045855006160 Recombination protein O C terminal; Region: RecO_C; pfam02565 1045855006161 GTPase Era; Reviewed; Region: era; PRK00089 1045855006162 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1045855006163 G1 box; other site 1045855006164 GTP/Mg2+ binding site [chemical binding]; other site 1045855006165 Switch I region; other site 1045855006166 G2 box; other site 1045855006167 Switch II region; other site 1045855006168 G3 box; other site 1045855006169 G4 box; other site 1045855006170 G5 box; other site 1045855006171 KH domain; Region: KH_2; pfam07650 1045855006172 ribonuclease III; Reviewed; Region: rnc; PRK00102 1045855006173 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1045855006174 dimerization interface [polypeptide binding]; other site 1045855006175 active site 1045855006176 metal binding site [ion binding]; metal-binding site 1045855006177 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1045855006178 dsRNA binding site [nucleotide binding]; other site 1045855006179 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1045855006180 signal peptidase I; Provisional; Region: PRK10861 1045855006181 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1045855006182 Catalytic site [active] 1045855006183 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1045855006184 GTP-binding protein LepA; Provisional; Region: PRK05433 1045855006185 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1045855006186 G1 box; other site 1045855006187 putative GEF interaction site [polypeptide binding]; other site 1045855006188 GTP/Mg2+ binding site [chemical binding]; other site 1045855006189 Switch I region; other site 1045855006190 G2 box; other site 1045855006191 G3 box; other site 1045855006192 Switch II region; other site 1045855006193 G4 box; other site 1045855006194 G5 box; other site 1045855006195 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1045855006196 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1045855006197 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1045855006198 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1045855006199 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1045855006200 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045855006201 protein binding site [polypeptide binding]; other site 1045855006202 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045855006203 protein binding site [polypeptide binding]; other site 1045855006204 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1045855006205 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1045855006206 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045855006207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045855006208 DNA binding residues [nucleotide binding] 1045855006209 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045855006210 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1045855006211 substrate binding site [chemical binding]; other site 1045855006212 oxyanion hole (OAH) forming residues; other site 1045855006213 trimer interface [polypeptide binding]; other site 1045855006214 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1045855006215 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1045855006216 PilZ domain; Region: PilZ; cl01260 1045855006217 DNA polymerase III subunit delta'; Validated; Region: PRK08769 1045855006218 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1045855006219 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1045855006220 thymidylate kinase; Validated; Region: tmk; PRK00698 1045855006221 TMP-binding site; other site 1045855006222 ATP-binding site [chemical binding]; other site 1045855006223 YceG-like family; Region: YceG; pfam02618 1045855006224 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1045855006225 dimerization interface [polypeptide binding]; other site 1045855006226 hypothetical protein; Validated; Region: PRK09070 1045855006227 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1045855006228 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1045855006229 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1045855006230 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1045855006231 dimer interface [polypeptide binding]; other site 1045855006232 active site 1045855006233 acyl carrier protein; Provisional; Region: acpP; PRK00982 1045855006234 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1045855006235 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1045855006236 NAD(P) binding site [chemical binding]; other site 1045855006237 homotetramer interface [polypeptide binding]; other site 1045855006238 homodimer interface [polypeptide binding]; other site 1045855006239 active site 1045855006240 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1045855006241 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1045855006242 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1045855006243 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1045855006244 dimer interface [polypeptide binding]; other site 1045855006245 active site 1045855006246 CoA binding pocket [chemical binding]; other site 1045855006247 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1045855006248 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1045855006249 Maf-like protein; Region: Maf; pfam02545 1045855006250 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1045855006251 active site 1045855006252 dimer interface [polypeptide binding]; other site 1045855006253 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1045855006254 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1045855006255 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1045855006256 MoxR-like ATPases [General function prediction only]; Region: COG0714 1045855006257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1045855006258 Walker B motif; other site 1045855006259 arginine finger; other site 1045855006260 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1045855006261 Protein of unknown function DUF58; Region: DUF58; pfam01882 1045855006262 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 1045855006263 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1045855006264 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1045855006265 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 1045855006266 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1045855006267 nucleotide binding site/active site [active] 1045855006268 recombination protein RecR; Reviewed; Region: recR; PRK00076 1045855006269 RecR protein; Region: RecR; pfam02132 1045855006270 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1045855006271 putative active site [active] 1045855006272 putative metal-binding site [ion binding]; other site 1045855006273 tetramer interface [polypeptide binding]; other site 1045855006274 hypothetical protein; Validated; Region: PRK00153 1045855006275 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1045855006276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855006277 Walker A motif; other site 1045855006278 ATP binding site [chemical binding]; other site 1045855006279 Walker B motif; other site 1045855006280 arginine finger; other site 1045855006281 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1045855006282 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1045855006283 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1045855006284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855006285 ATP binding site [chemical binding]; other site 1045855006286 putative Mg++ binding site [ion binding]; other site 1045855006287 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1045855006288 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1045855006289 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1045855006290 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1045855006291 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1045855006292 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1045855006293 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1045855006294 GIY-YIG motif/motif A; other site 1045855006295 active site 1045855006296 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1045855006297 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1045855006298 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1045855006299 S-adenosylmethionine binding site [chemical binding]; other site 1045855006300 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1045855006301 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1045855006302 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 1045855006303 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1045855006304 phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299 1045855006305 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1045855006306 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1045855006307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855006308 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1045855006309 Walker A motif; other site 1045855006310 ATP binding site [chemical binding]; other site 1045855006311 Walker B motif; other site 1045855006312 arginine finger; other site 1045855006313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1045855006314 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1045855006315 DNA-binding interface [nucleotide binding]; DNA binding site 1045855006316 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 1045855006317 active site 1045855006318 catalytic triad [active] 1045855006319 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1045855006320 DNA binding residues [nucleotide binding] 1045855006321 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1045855006322 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1045855006323 Part of AAA domain; Region: AAA_19; pfam13245 1045855006324 Family description; Region: UvrD_C_2; pfam13538 1045855006325 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1045855006326 ATP binding site [chemical binding]; other site 1045855006327 substrate interface [chemical binding]; other site 1045855006328 Peptidase U49; Region: Peptidase_U49; pfam10463 1045855006329 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1045855006330 HSP70 interaction site [polypeptide binding]; other site 1045855006331 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 1045855006332 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1045855006333 nucleophilic elbow; other site 1045855006334 catalytic triad; other site 1045855006335 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1045855006336 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1045855006337 active site 1045855006338 Int/Topo IB signature motif; other site 1045855006339 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1045855006340 MoaE homodimer interface [polypeptide binding]; other site 1045855006341 MoaD interaction [polypeptide binding]; other site 1045855006342 active site residues [active] 1045855006343 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1045855006344 MoaE interaction surface [polypeptide binding]; other site 1045855006345 MoeB interaction surface [polypeptide binding]; other site 1045855006346 thiocarboxylated glycine; other site 1045855006347 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1045855006348 trimer interface [polypeptide binding]; other site 1045855006349 dimer interface [polypeptide binding]; other site 1045855006350 putative active site [active] 1045855006351 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1045855006352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045855006353 FeS/SAM binding site; other site 1045855006354 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1045855006355 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045855006356 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 1045855006357 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1045855006358 active site 1045855006359 ATP binding site [chemical binding]; other site 1045855006360 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1045855006361 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1045855006362 putative active site [active] 1045855006363 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1045855006364 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1045855006365 classical (c) SDRs; Region: SDR_c; cd05233 1045855006366 NAD(P) binding site [chemical binding]; other site 1045855006367 active site 1045855006368 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045855006369 active site 1045855006370 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045855006371 catalytic tetrad [active] 1045855006372 putative phosphoketolase; Provisional; Region: PRK05261 1045855006373 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1045855006374 TPP-binding site; other site 1045855006375 XFP C-terminal domain; Region: XFP_C; pfam09363 1045855006376 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1045855006377 Protein phosphatase 2C; Region: PP2C; pfam00481 1045855006378 active site 1045855006379 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1045855006380 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1045855006381 active site 1045855006382 catalytic site [active] 1045855006383 substrate binding site [chemical binding]; other site 1045855006384 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1045855006385 RNA/DNA hybrid binding site [nucleotide binding]; other site 1045855006386 active site 1045855006387 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1045855006388 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1045855006389 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045855006390 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045855006391 catalytic residue [active] 1045855006392 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045855006393 periplasmic folding chaperone; Provisional; Region: PRK10788 1045855006394 SurA N-terminal domain; Region: SurA_N_3; cl07813 1045855006395 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1045855006396 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1045855006397 IHF dimer interface [polypeptide binding]; other site 1045855006398 IHF - DNA interface [nucleotide binding]; other site 1045855006399 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1045855006400 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1045855006401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855006402 Walker A motif; other site 1045855006403 ATP binding site [chemical binding]; other site 1045855006404 Walker B motif; other site 1045855006405 arginine finger; other site 1045855006406 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1045855006407 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1045855006408 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1045855006409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855006410 Walker A motif; other site 1045855006411 ATP binding site [chemical binding]; other site 1045855006412 Walker B motif; other site 1045855006413 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1045855006414 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1045855006415 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1045855006416 oligomer interface [polypeptide binding]; other site 1045855006417 active site residues [active] 1045855006418 trigger factor; Provisional; Region: tig; PRK01490 1045855006419 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1045855006420 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1045855006421 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1045855006422 Protein of unknown function DUF58; Region: DUF58; pfam01882 1045855006423 MoxR-like ATPases [General function prediction only]; Region: COG0714 1045855006424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855006425 Walker A motif; other site 1045855006426 ATP binding site [chemical binding]; other site 1045855006427 Walker B motif; other site 1045855006428 arginine finger; other site 1045855006429 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1045855006430 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1045855006431 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1045855006432 isocitrate dehydrogenase; Provisional; Region: PRK08997 1045855006433 tartrate dehydrogenase; Region: TTC; TIGR02089 1045855006434 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1045855006435 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1045855006436 GSH binding site [chemical binding]; other site 1045855006437 catalytic residues [active] 1045855006438 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1045855006439 Peptidase family M48; Region: Peptidase_M48; pfam01435 1045855006440 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1045855006441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855006442 active site 1045855006443 phosphorylation site [posttranslational modification] 1045855006444 intermolecular recognition site; other site 1045855006445 dimerization interface [polypeptide binding]; other site 1045855006446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855006447 DNA binding site [nucleotide binding] 1045855006448 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1045855006449 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1045855006450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855006451 dimer interface [polypeptide binding]; other site 1045855006452 phosphorylation site [posttranslational modification] 1045855006453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855006454 ATP binding site [chemical binding]; other site 1045855006455 Mg2+ binding site [ion binding]; other site 1045855006456 G-X-G motif; other site 1045855006457 polyphosphate kinase; Provisional; Region: PRK05443 1045855006458 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1045855006459 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1045855006460 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1045855006461 putative active site [active] 1045855006462 catalytic site [active] 1045855006463 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1045855006464 putative domain interface [polypeptide binding]; other site 1045855006465 putative active site [active] 1045855006466 catalytic site [active] 1045855006467 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1045855006468 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1045855006469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1045855006470 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1045855006471 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1045855006472 active site 1045855006473 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1045855006474 M28 Zn-Peptidases; Region: M28_like_4; cd08015 1045855006475 Peptidase family M28; Region: Peptidase_M28; pfam04389 1045855006476 metal binding site [ion binding]; metal-binding site 1045855006477 inner membrane protein; Provisional; Region: PRK11715 1045855006478 Predicted membrane protein [Function unknown]; Region: COG2733 1045855006479 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1045855006480 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1045855006481 Zn binding site [ion binding]; other site 1045855006482 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1045855006483 active site 1045855006484 substrate binding pocket [chemical binding]; other site 1045855006485 dimer interface [polypeptide binding]; other site 1045855006486 DNA binding domain, excisionase family; Region: excise; TIGR01764 1045855006487 Protein of unknown function DUF262; Region: DUF262; pfam03235 1045855006488 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1045855006489 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1045855006490 Protein of unknown function DUF262; Region: DUF262; pfam03235 1045855006491 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1045855006492 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1045855006493 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1045855006494 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1045855006495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1045855006496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855006497 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1045855006498 MOSC domain; Region: MOSC; pfam03473 1045855006499 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1045855006500 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 1045855006501 substrate binding site [chemical binding]; other site 1045855006502 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1045855006503 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1045855006504 HflX GTPase family; Region: HflX; cd01878 1045855006505 G1 box; other site 1045855006506 GTP/Mg2+ binding site [chemical binding]; other site 1045855006507 Switch I region; other site 1045855006508 G2 box; other site 1045855006509 G3 box; other site 1045855006510 Switch II region; other site 1045855006511 G4 box; other site 1045855006512 G5 box; other site 1045855006513 bacterial Hfq-like; Region: Hfq; cd01716 1045855006514 hexamer interface [polypeptide binding]; other site 1045855006515 Sm1 motif; other site 1045855006516 RNA binding site [nucleotide binding]; other site 1045855006517 Sm2 motif; other site 1045855006518 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1045855006519 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1045855006520 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1045855006521 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1045855006522 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1045855006523 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1045855006524 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1045855006525 Ligand binding site; other site 1045855006526 Putative Catalytic site; other site 1045855006527 DXD motif; other site 1045855006528 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 1045855006529 excinuclease ABC subunit B; Provisional; Region: PRK05298 1045855006530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855006531 ATP binding site [chemical binding]; other site 1045855006532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855006533 nucleotide binding region [chemical binding]; other site 1045855006534 ATP-binding site [chemical binding]; other site 1045855006535 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1045855006536 UvrB/uvrC motif; Region: UVR; pfam02151 1045855006537 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1045855006538 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1045855006539 Type II transport protein GspH; Region: GspH; pfam12019 1045855006540 Type II transport protein GspH; Region: GspH; pfam12019 1045855006541 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1045855006542 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 1045855006543 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1045855006544 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 1045855006545 PilX N-terminal; Region: PilX_N; pfam14341 1045855006546 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1045855006547 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 1045855006548 Histidine kinase; Region: His_kinase; pfam06580 1045855006549 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1045855006550 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1045855006551 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1045855006552 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1045855006553 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855006554 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855006555 MarC family integral membrane protein; Region: MarC; cl00919 1045855006556 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1045855006557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855006558 NAD(P) binding site [chemical binding]; other site 1045855006559 active site 1045855006560 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1045855006561 putative GSH binding site [chemical binding]; other site 1045855006562 catalytic residues [active] 1045855006563 superoxide dismutase; Provisional; Region: PRK10543 1045855006564 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1045855006565 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1045855006566 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1045855006567 ATP-grasp domain; Region: ATP-grasp; pfam02222 1045855006568 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1045855006569 Trm112p-like protein; Region: Trm112p; cl01066 1045855006570 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1045855006571 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1045855006572 dimerization interface [polypeptide binding]; other site 1045855006573 active site 1045855006574 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 1045855006575 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1045855006576 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1045855006577 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1045855006578 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1045855006579 C-terminal domain interface [polypeptide binding]; other site 1045855006580 putative GSH binding site (G-site) [chemical binding]; other site 1045855006581 dimer interface [polypeptide binding]; other site 1045855006582 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1045855006583 N-terminal domain interface [polypeptide binding]; other site 1045855006584 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1045855006585 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1045855006586 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1045855006587 Qi binding site; other site 1045855006588 intrachain domain interface; other site 1045855006589 interchain domain interface [polypeptide binding]; other site 1045855006590 heme bH binding site [chemical binding]; other site 1045855006591 heme bL binding site [chemical binding]; other site 1045855006592 Qo binding site; other site 1045855006593 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1045855006594 interchain domain interface [polypeptide binding]; other site 1045855006595 intrachain domain interface; other site 1045855006596 Qi binding site; other site 1045855006597 Qo binding site; other site 1045855006598 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1045855006599 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1045855006600 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1045855006601 [2Fe-2S] cluster binding site [ion binding]; other site 1045855006602 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1045855006603 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045855006604 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045855006605 catalytic residue [active] 1045855006606 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1045855006607 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1045855006608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045855006609 FeS/SAM binding site; other site 1045855006610 TRAM domain; Region: TRAM; pfam01938 1045855006611 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1045855006612 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1045855006613 PhoH-like protein; Region: PhoH; pfam02562 1045855006614 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 1045855006615 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1045855006616 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1045855006617 Transporter associated domain; Region: CorC_HlyC; smart01091 1045855006618 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1045855006619 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 1045855006620 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1045855006621 active site 1045855006622 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1045855006623 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1045855006624 catalytic Zn binding site [ion binding]; other site 1045855006625 structural Zn binding site [ion binding]; other site 1045855006626 NAD(P) binding site [chemical binding]; other site 1045855006627 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1045855006628 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045855006629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855006630 Walker A/P-loop; other site 1045855006631 ATP binding site [chemical binding]; other site 1045855006632 Q-loop/lid; other site 1045855006633 ABC transporter signature motif; other site 1045855006634 Walker B; other site 1045855006635 D-loop; other site 1045855006636 H-loop/switch region; other site 1045855006637 Protein of unknown function DUF72; Region: DUF72; pfam01904 1045855006638 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1045855006639 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045855006640 RNA binding surface [nucleotide binding]; other site 1045855006641 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1045855006642 probable active site [active] 1045855006643 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1045855006644 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1045855006645 ATP binding site [chemical binding]; other site 1045855006646 Mg++ binding site [ion binding]; other site 1045855006647 motif III; other site 1045855006648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855006649 nucleotide binding region [chemical binding]; other site 1045855006650 ATP-binding site [chemical binding]; other site 1045855006651 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1045855006652 putative RNA binding site [nucleotide binding]; other site 1045855006653 S4 domain; Region: S4_2; pfam13275 1045855006654 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1045855006655 Sulfatase; Region: Sulfatase; cl17466 1045855006656 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1045855006657 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1045855006658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1045855006659 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1045855006660 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1045855006661 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1045855006662 minor groove reading motif; other site 1045855006663 helix-hairpin-helix signature motif; other site 1045855006664 substrate binding pocket [chemical binding]; other site 1045855006665 active site 1045855006666 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1045855006667 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1045855006668 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1045855006669 DNA binding site [nucleotide binding] 1045855006670 active site 1045855006671 MerC mercury resistance protein; Region: MerC; pfam03203 1045855006672 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855006673 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045855006674 N-terminal plug; other site 1045855006675 ligand-binding site [chemical binding]; other site 1045855006676 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1045855006677 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1045855006678 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1045855006679 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1045855006680 metal binding site 2 [ion binding]; metal-binding site 1045855006681 putative DNA binding helix; other site 1045855006682 metal binding site 1 [ion binding]; metal-binding site 1045855006683 dimer interface [polypeptide binding]; other site 1045855006684 structural Zn2+ binding site [ion binding]; other site 1045855006685 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1045855006686 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1045855006687 active site 1045855006688 HIGH motif; other site 1045855006689 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1045855006690 active site 1045855006691 KMSKS motif; other site 1045855006692 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1045855006693 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1045855006694 putative active site [active] 1045855006695 putative metal binding site [ion binding]; other site 1045855006696 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1045855006697 dinuclear metal binding motif [ion binding]; other site 1045855006698 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1045855006699 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1045855006700 active site 1045855006701 tetramer interface [polypeptide binding]; other site 1045855006702 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045855006703 active site 1045855006704 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1045855006705 Colicin V production protein; Region: Colicin_V; pfam02674 1045855006706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 1045855006707 Sporulation related domain; Region: SPOR; pfam05036 1045855006708 Sporulation related domain; Region: SPOR; pfam05036 1045855006709 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1045855006710 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045855006711 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045855006712 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1045855006713 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1045855006714 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1045855006715 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1045855006716 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045855006717 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1045855006718 N-terminal plug; other site 1045855006719 ligand-binding site [chemical binding]; other site 1045855006720 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1045855006721 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1045855006722 NAD(P) binding site [chemical binding]; other site 1045855006723 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1045855006724 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1045855006725 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1045855006726 Walker A/P-loop; other site 1045855006727 ATP binding site [chemical binding]; other site 1045855006728 Q-loop/lid; other site 1045855006729 ABC transporter signature motif; other site 1045855006730 Walker B; other site 1045855006731 D-loop; other site 1045855006732 H-loop/switch region; other site 1045855006733 TOBE domain; Region: TOBE_2; pfam08402 1045855006734 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1045855006735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855006736 dimer interface [polypeptide binding]; other site 1045855006737 conserved gate region; other site 1045855006738 putative PBP binding loops; other site 1045855006739 ABC-ATPase subunit interface; other site 1045855006740 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1045855006741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855006742 dimer interface [polypeptide binding]; other site 1045855006743 conserved gate region; other site 1045855006744 putative PBP binding loops; other site 1045855006745 ABC-ATPase subunit interface; other site 1045855006746 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1045855006747 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1045855006748 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1045855006749 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1045855006750 substrate-cofactor binding pocket; other site 1045855006751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855006752 catalytic residue [active] 1045855006753 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1045855006754 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1045855006755 active site 1045855006756 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1045855006757 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1045855006758 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045855006759 ligand binding site [chemical binding]; other site 1045855006760 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1045855006761 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1045855006762 active site 1045855006763 FMN binding site [chemical binding]; other site 1045855006764 2,4-decadienoyl-CoA binding site; other site 1045855006765 catalytic residue [active] 1045855006766 4Fe-4S cluster binding site [ion binding]; other site 1045855006767 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1045855006768 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045855006769 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1045855006770 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1045855006771 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1045855006772 dimer interface [polypeptide binding]; other site 1045855006773 active site 1045855006774 citrylCoA binding site [chemical binding]; other site 1045855006775 oxalacetate/citrate binding site [chemical binding]; other site 1045855006776 coenzyme A binding site [chemical binding]; other site 1045855006777 catalytic triad [active] 1045855006778 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1045855006779 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1045855006780 tetramer interface [polypeptide binding]; other site 1045855006781 active site 1045855006782 Mg2+/Mn2+ binding site [ion binding]; other site 1045855006783 Helix-turn-helix domain; Region: HTH_17; pfam12728 1045855006784 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 1045855006785 dimer interface [polypeptide binding]; other site 1045855006786 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1045855006787 active site 1045855006788 oxalacetate/citrate binding site [chemical binding]; other site 1045855006789 citrylCoA binding site [chemical binding]; other site 1045855006790 coenzyme A binding site [chemical binding]; other site 1045855006791 catalytic triad [active] 1045855006792 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1045855006793 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045855006794 acyl-activating enzyme (AAE) consensus motif; other site 1045855006795 AMP binding site [chemical binding]; other site 1045855006796 active site 1045855006797 CoA binding site [chemical binding]; other site 1045855006798 acyl-CoA synthetase; Validated; Region: PRK08162 1045855006799 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1045855006800 acyl-activating enzyme (AAE) consensus motif; other site 1045855006801 putative active site [active] 1045855006802 AMP binding site [chemical binding]; other site 1045855006803 putative CoA binding site [chemical binding]; other site 1045855006804 malate dehydrogenase; Provisional; Region: PRK05442 1045855006805 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1045855006806 NAD(P) binding site [chemical binding]; other site 1045855006807 dimer interface [polypeptide binding]; other site 1045855006808 malate binding site [chemical binding]; other site 1045855006809 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1045855006810 active site 1045855006811 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1045855006812 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1045855006813 G1 box; other site 1045855006814 putative GEF interaction site [polypeptide binding]; other site 1045855006815 GTP/Mg2+ binding site [chemical binding]; other site 1045855006816 Switch I region; other site 1045855006817 G2 box; other site 1045855006818 G3 box; other site 1045855006819 Switch II region; other site 1045855006820 G4 box; other site 1045855006821 G5 box; other site 1045855006822 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1045855006823 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1045855006824 amidase; Provisional; Region: PRK08137 1045855006825 Amidase; Region: Amidase; cl11426 1045855006826 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1045855006827 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045855006828 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1045855006829 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1045855006830 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1045855006831 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1045855006832 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1045855006833 alphaNTD homodimer interface [polypeptide binding]; other site 1045855006834 alphaNTD - beta interaction site [polypeptide binding]; other site 1045855006835 alphaNTD - beta' interaction site [polypeptide binding]; other site 1045855006836 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1045855006837 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1045855006838 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1045855006839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045855006840 RNA binding surface [nucleotide binding]; other site 1045855006841 30S ribosomal protein S11; Validated; Region: PRK05309 1045855006842 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1045855006843 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1045855006844 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1045855006845 SecY translocase; Region: SecY; pfam00344 1045855006846 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1045855006847 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1045855006848 23S rRNA binding site [nucleotide binding]; other site 1045855006849 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1045855006850 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1045855006851 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1045855006852 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1045855006853 5S rRNA interface [nucleotide binding]; other site 1045855006854 23S rRNA interface [nucleotide binding]; other site 1045855006855 L5 interface [polypeptide binding]; other site 1045855006856 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1045855006857 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1045855006858 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1045855006859 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1045855006860 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1045855006861 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1045855006862 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1045855006863 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1045855006864 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1045855006865 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1045855006866 RNA binding site [nucleotide binding]; other site 1045855006867 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1045855006868 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1045855006869 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1045855006870 putative translocon interaction site; other site 1045855006871 23S rRNA interface [nucleotide binding]; other site 1045855006872 signal recognition particle (SRP54) interaction site; other site 1045855006873 L23 interface [polypeptide binding]; other site 1045855006874 trigger factor interaction site; other site 1045855006875 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1045855006876 23S rRNA interface [nucleotide binding]; other site 1045855006877 5S rRNA interface [nucleotide binding]; other site 1045855006878 putative antibiotic binding site [chemical binding]; other site 1045855006879 L25 interface [polypeptide binding]; other site 1045855006880 L27 interface [polypeptide binding]; other site 1045855006881 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1045855006882 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1045855006883 G-X-X-G motif; other site 1045855006884 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1045855006885 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1045855006886 putative translocon binding site; other site 1045855006887 protein-rRNA interface [nucleotide binding]; other site 1045855006888 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1045855006889 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1045855006890 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1045855006891 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1045855006892 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1045855006893 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1045855006894 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1045855006895 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1045855006896 elongation factor Tu; Reviewed; Region: PRK00049 1045855006897 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1045855006898 G1 box; other site 1045855006899 GEF interaction site [polypeptide binding]; other site 1045855006900 GTP/Mg2+ binding site [chemical binding]; other site 1045855006901 Switch I region; other site 1045855006902 G2 box; other site 1045855006903 G3 box; other site 1045855006904 Switch II region; other site 1045855006905 G4 box; other site 1045855006906 G5 box; other site 1045855006907 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1045855006908 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1045855006909 Antibiotic Binding Site [chemical binding]; other site 1045855006910 elongation factor G; Reviewed; Region: PRK00007 1045855006911 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1045855006912 G1 box; other site 1045855006913 putative GEF interaction site [polypeptide binding]; other site 1045855006914 GTP/Mg2+ binding site [chemical binding]; other site 1045855006915 Switch I region; other site 1045855006916 G2 box; other site 1045855006917 G3 box; other site 1045855006918 Switch II region; other site 1045855006919 G4 box; other site 1045855006920 G5 box; other site 1045855006921 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1045855006922 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1045855006923 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1045855006924 30S ribosomal protein S7; Validated; Region: PRK05302 1045855006925 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1045855006926 S17 interaction site [polypeptide binding]; other site 1045855006927 S8 interaction site; other site 1045855006928 16S rRNA interaction site [nucleotide binding]; other site 1045855006929 streptomycin interaction site [chemical binding]; other site 1045855006930 23S rRNA interaction site [nucleotide binding]; other site 1045855006931 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1045855006932 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1045855006933 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 1045855006934 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1045855006935 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1045855006936 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1045855006937 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1045855006938 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1045855006939 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1045855006940 DNA binding site [nucleotide binding] 1045855006941 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1045855006942 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1045855006943 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1045855006944 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1045855006945 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1045855006946 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1045855006947 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1045855006948 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1045855006949 RPB3 interaction site [polypeptide binding]; other site 1045855006950 RPB1 interaction site [polypeptide binding]; other site 1045855006951 RPB11 interaction site [polypeptide binding]; other site 1045855006952 RPB10 interaction site [polypeptide binding]; other site 1045855006953 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1045855006954 core dimer interface [polypeptide binding]; other site 1045855006955 peripheral dimer interface [polypeptide binding]; other site 1045855006956 L10 interface [polypeptide binding]; other site 1045855006957 L11 interface [polypeptide binding]; other site 1045855006958 putative EF-Tu interaction site [polypeptide binding]; other site 1045855006959 putative EF-G interaction site [polypeptide binding]; other site 1045855006960 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1045855006961 23S rRNA interface [nucleotide binding]; other site 1045855006962 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1045855006963 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1045855006964 mRNA/rRNA interface [nucleotide binding]; other site 1045855006965 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1045855006966 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1045855006967 23S rRNA interface [nucleotide binding]; other site 1045855006968 L7/L12 interface [polypeptide binding]; other site 1045855006969 putative thiostrepton binding site; other site 1045855006970 L25 interface [polypeptide binding]; other site 1045855006971 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1045855006972 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1045855006973 putative homodimer interface [polypeptide binding]; other site 1045855006974 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1045855006975 heterodimer interface [polypeptide binding]; other site 1045855006976 homodimer interface [polypeptide binding]; other site 1045855006977 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1045855006978 elongation factor Tu; Reviewed; Region: PRK00049 1045855006979 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1045855006980 G1 box; other site 1045855006981 GEF interaction site [polypeptide binding]; other site 1045855006982 GTP/Mg2+ binding site [chemical binding]; other site 1045855006983 Switch I region; other site 1045855006984 G2 box; other site 1045855006985 G3 box; other site 1045855006986 Switch II region; other site 1045855006987 G4 box; other site 1045855006988 G5 box; other site 1045855006989 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1045855006990 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1045855006991 Antibiotic Binding Site [chemical binding]; other site 1045855006992 GTP-binding protein YchF; Reviewed; Region: PRK09601 1045855006993 YchF GTPase; Region: YchF; cd01900 1045855006994 G1 box; other site 1045855006995 GTP/Mg2+ binding site [chemical binding]; other site 1045855006996 Switch I region; other site 1045855006997 G2 box; other site 1045855006998 Switch II region; other site 1045855006999 G3 box; other site 1045855007000 G4 box; other site 1045855007001 G5 box; other site 1045855007002 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1045855007003 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1045855007004 putative active site [active] 1045855007005 catalytic residue [active] 1045855007006 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1045855007007 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1045855007008 5S rRNA interface [nucleotide binding]; other site 1045855007009 CTC domain interface [polypeptide binding]; other site 1045855007010 L16 interface [polypeptide binding]; other site 1045855007011 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 1045855007012 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1045855007013 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045855007014 active site 1045855007015 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1045855007016 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1045855007017 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1045855007018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855007019 TPR motif; other site 1045855007020 binding surface 1045855007021 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1045855007022 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1045855007023 tRNA; other site 1045855007024 putative tRNA binding site [nucleotide binding]; other site 1045855007025 putative NADP binding site [chemical binding]; other site 1045855007026 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1045855007027 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1045855007028 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1045855007029 RF-1 domain; Region: RF-1; pfam00472 1045855007030 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1045855007031 MPT binding site; other site 1045855007032 trimer interface [polypeptide binding]; other site 1045855007033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1045855007034 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1045855007035 Acylphosphatase; Region: Acylphosphatase; pfam00708 1045855007036 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1045855007037 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045855007038 catalytic residues [active] 1045855007039 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 1045855007040 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1045855007041 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045855007042 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045855007043 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 1045855007044 active site 1045855007045 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1045855007046 active site 1045855007047 catalytic triad [active] 1045855007048 FOG: PKD repeat [General function prediction only]; Region: COG3291 1045855007049 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1045855007050 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1045855007051 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1045855007052 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1045855007053 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1045855007054 homodimer interface [polypeptide binding]; other site 1045855007055 substrate-cofactor binding pocket; other site 1045855007056 catalytic residue [active] 1045855007057 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 1045855007058 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1045855007059 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1045855007060 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1045855007061 RNA polymerase factor sigma-70; Validated; Region: PRK09047 1045855007062 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045855007063 DNA binding residues [nucleotide binding] 1045855007064 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 1045855007065 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1045855007066 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1045855007067 ligand binding site [chemical binding]; other site 1045855007068 homodimer interface [polypeptide binding]; other site 1045855007069 NAD(P) binding site [chemical binding]; other site 1045855007070 trimer interface B [polypeptide binding]; other site 1045855007071 trimer interface A [polypeptide binding]; other site 1045855007072 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 1045855007073 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1045855007074 putative FMN binding site [chemical binding]; other site 1045855007075 5'-3' exonuclease; Region: 53EXOc; smart00475 1045855007076 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1045855007077 active site 1045855007078 metal binding site 1 [ion binding]; metal-binding site 1045855007079 putative 5' ssDNA interaction site; other site 1045855007080 metal binding site 3; metal-binding site 1045855007081 metal binding site 2 [ion binding]; metal-binding site 1045855007082 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1045855007083 putative DNA binding site [nucleotide binding]; other site 1045855007084 putative metal binding site [ion binding]; other site 1045855007085 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1045855007086 dimer interface [polypeptide binding]; other site 1045855007087 active site 1045855007088 ADP-ribose binding site [chemical binding]; other site 1045855007089 nudix motif; other site 1045855007090 metal binding site [ion binding]; metal-binding site 1045855007091 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1045855007092 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1045855007093 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1045855007094 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1045855007095 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1045855007096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855007097 peroxiredoxin; Region: AhpC; TIGR03137 1045855007098 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1045855007099 dimer interface [polypeptide binding]; other site 1045855007100 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1045855007101 catalytic triad [active] 1045855007102 peroxidatic and resolving cysteines [active] 1045855007103 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1045855007104 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1045855007105 catalytic residue [active] 1045855007106 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1045855007107 catalytic residues [active] 1045855007108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045855007109 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045855007110 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1045855007111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855007112 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1045855007113 dimerization interface [polypeptide binding]; other site 1045855007114 transaldolase-like protein; Provisional; Region: PTZ00411 1045855007115 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1045855007116 active site 1045855007117 dimer interface [polypeptide binding]; other site 1045855007118 catalytic residue [active] 1045855007119 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1045855007120 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 1045855007121 active site 1045855007122 intersubunit interface [polypeptide binding]; other site 1045855007123 catalytic residue [active] 1045855007124 pyruvate kinase; Provisional; Region: PRK05826 1045855007125 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1045855007126 domain interfaces; other site 1045855007127 active site 1045855007128 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1045855007129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855007130 motif II; other site 1045855007131 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1045855007132 Phosphoglycerate kinase; Region: PGK; pfam00162 1045855007133 substrate binding site [chemical binding]; other site 1045855007134 hinge regions; other site 1045855007135 ADP binding site [chemical binding]; other site 1045855007136 catalytic site [active] 1045855007137 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1045855007138 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1045855007139 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1045855007140 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1045855007141 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1045855007142 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1045855007143 OmpW family; Region: OmpW; cl17427 1045855007144 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 1045855007145 active site 1045855007146 Zn binding site [ion binding]; other site 1045855007147 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1045855007148 thioredoxin 2; Provisional; Region: PRK10996 1045855007149 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1045855007150 catalytic residues [active] 1045855007151 OsmC-like protein; Region: OsmC; pfam02566 1045855007152 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1045855007153 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1045855007154 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1045855007155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045855007156 putative PBP binding loops; other site 1045855007157 ABC-ATPase subunit interface; other site 1045855007158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855007159 Walker A/P-loop; other site 1045855007160 ATP binding site [chemical binding]; other site 1045855007161 Q-loop/lid; other site 1045855007162 ABC transporter signature motif; other site 1045855007163 Walker B; other site 1045855007164 D-loop; other site 1045855007165 H-loop/switch region; other site 1045855007166 EcsC protein family; Region: EcsC; pfam12787 1045855007167 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1045855007168 HD domain; Region: HD_4; pfam13328 1045855007169 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1045855007170 synthetase active site [active] 1045855007171 NTP binding site [chemical binding]; other site 1045855007172 metal binding site [ion binding]; metal-binding site 1045855007173 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1045855007174 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1045855007175 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1045855007176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855007177 ATP binding site [chemical binding]; other site 1045855007178 putative Mg++ binding site [ion binding]; other site 1045855007179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855007180 nucleotide binding region [chemical binding]; other site 1045855007181 ATP-binding site [chemical binding]; other site 1045855007182 Helicase associated domain (HA2); Region: HA2; pfam04408 1045855007183 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1045855007184 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1045855007185 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1045855007186 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1045855007187 dimerization interface [polypeptide binding]; other site 1045855007188 DPS ferroxidase diiron center [ion binding]; other site 1045855007189 ion pore; other site 1045855007190 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1045855007191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855007192 ATP binding site [chemical binding]; other site 1045855007193 putative Mg++ binding site [ion binding]; other site 1045855007194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855007195 nucleotide binding region [chemical binding]; other site 1045855007196 ATP-binding site [chemical binding]; other site 1045855007197 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1045855007198 HRDC domain; Region: HRDC; pfam00570 1045855007199 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1045855007200 YHS domain; Region: YHS; pfam04945 1045855007201 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1045855007202 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045855007203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855007204 motif II; other site 1045855007205 SnoaL-like domain; Region: SnoaL_2; pfam12680 1045855007206 SnoaL-like domain; Region: SnoaL_3; pfam13474 1045855007207 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1045855007208 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1045855007209 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1045855007210 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1045855007211 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1045855007212 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1045855007213 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1045855007214 Walker A motif; other site 1045855007215 ATP binding site [chemical binding]; other site 1045855007216 Walker B motif; other site 1045855007217 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1045855007218 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1045855007219 Walker A motif; other site 1045855007220 ATP binding site [chemical binding]; other site 1045855007221 Walker B motif; other site 1045855007222 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1045855007223 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045855007224 catalytic residue [active] 1045855007225 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1045855007226 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1045855007227 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1045855007228 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1045855007229 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1045855007230 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1045855007231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855007232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045855007233 DNA binding site [nucleotide binding] 1045855007234 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1045855007235 active site 1045855007236 ATP binding site [chemical binding]; other site 1045855007237 substrate binding site [chemical binding]; other site 1045855007238 activation loop (A-loop); other site 1045855007239 shikimate kinase; Reviewed; Region: aroK; PRK00131 1045855007240 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1045855007241 ADP binding site [chemical binding]; other site 1045855007242 magnesium binding site [ion binding]; other site 1045855007243 putative shikimate binding site; other site 1045855007244 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1045855007245 active site 1045855007246 dimer interface [polypeptide binding]; other site 1045855007247 metal binding site [ion binding]; metal-binding site 1045855007248 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1045855007249 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1045855007250 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1045855007251 substrate binding site [chemical binding]; other site 1045855007252 active site 1045855007253 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1045855007254 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1045855007255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855007256 dimer interface [polypeptide binding]; other site 1045855007257 phosphorylation site [posttranslational modification] 1045855007258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855007259 ATP binding site [chemical binding]; other site 1045855007260 Mg2+ binding site [ion binding]; other site 1045855007261 G-X-G motif; other site 1045855007262 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855007263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855007264 active site 1045855007265 phosphorylation site [posttranslational modification] 1045855007266 intermolecular recognition site; other site 1045855007267 dimerization interface [polypeptide binding]; other site 1045855007268 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1045855007269 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1045855007270 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1045855007271 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1045855007272 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1045855007273 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1045855007274 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1045855007275 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1045855007276 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1045855007277 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855007278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855007279 metal binding site [ion binding]; metal-binding site 1045855007280 active site 1045855007281 I-site; other site 1045855007282 Integrase core domain; Region: rve_3; cl15866 1045855007283 Homeodomain-like domain; Region: HTH_23; pfam13384 1045855007284 Winged helix-turn helix; Region: HTH_29; pfam13551 1045855007285 Homeodomain-like domain; Region: HTH_32; pfam13565 1045855007286 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1045855007287 Sulfatase; Region: Sulfatase; cl17466 1045855007288 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045855007289 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1045855007290 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855007291 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855007292 metal binding site [ion binding]; metal-binding site 1045855007293 active site 1045855007294 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1045855007295 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045855007296 cystathionine gamma-synthase; Provisional; Region: PRK08776 1045855007297 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1045855007298 homodimer interface [polypeptide binding]; other site 1045855007299 substrate-cofactor binding pocket; other site 1045855007300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855007301 catalytic residue [active] 1045855007302 homoserine O-acetyltransferase; Provisional; Region: PRK08775 1045855007303 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1045855007304 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045855007305 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045855007306 MarR family; Region: MarR_2; cl17246 1045855007307 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1045855007308 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1045855007309 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1045855007310 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1045855007311 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045855007312 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1045855007313 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855007314 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1045855007315 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1045855007316 dimer interface [polypeptide binding]; other site 1045855007317 active site 1045855007318 citrylCoA binding site [chemical binding]; other site 1045855007319 NADH binding [chemical binding]; other site 1045855007320 cationic pore residues; other site 1045855007321 oxalacetate/citrate binding site [chemical binding]; other site 1045855007322 coenzyme A binding site [chemical binding]; other site 1045855007323 catalytic triad [active] 1045855007324 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1045855007325 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649 1045855007326 active site 1045855007327 Y-family of DNA polymerases; Region: PolY; cl12025 1045855007328 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1045855007329 generic binding surface II; other site 1045855007330 ssDNA binding site; other site 1045855007331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855007332 ATP binding site [chemical binding]; other site 1045855007333 putative Mg++ binding site [ion binding]; other site 1045855007334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855007335 nucleotide binding region [chemical binding]; other site 1045855007336 ATP-binding site [chemical binding]; other site 1045855007337 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1045855007338 homotrimer interaction site [polypeptide binding]; other site 1045855007339 putative active site [active] 1045855007340 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1045855007341 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045855007342 Zn2+ binding site [ion binding]; other site 1045855007343 Mg2+ binding site [ion binding]; other site 1045855007344 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1045855007345 synthetase active site [active] 1045855007346 NTP binding site [chemical binding]; other site 1045855007347 metal binding site [ion binding]; metal-binding site 1045855007348 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1045855007349 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1045855007350 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1045855007351 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1045855007352 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1045855007353 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1045855007354 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1045855007355 catalytic site [active] 1045855007356 G-X2-G-X-G-K; other site 1045855007357 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1045855007358 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1045855007359 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1045855007360 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1045855007361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045855007362 non-specific DNA binding site [nucleotide binding]; other site 1045855007363 salt bridge; other site 1045855007364 sequence-specific DNA binding site [nucleotide binding]; other site 1045855007365 hypothetical protein; Provisional; Region: PRK11820 1045855007366 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1045855007367 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1045855007368 ribonuclease PH; Reviewed; Region: rph; PRK00173 1045855007369 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1045855007370 hexamer interface [polypeptide binding]; other site 1045855007371 active site 1045855007372 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1045855007373 active site 1045855007374 dimerization interface [polypeptide binding]; other site 1045855007375 HemN family oxidoreductase; Provisional; Region: PRK05660 1045855007376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045855007377 FeS/SAM binding site; other site 1045855007378 HemN C-terminal domain; Region: HemN_C; pfam06969 1045855007379 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 1045855007380 PilZ domain; Region: PilZ; pfam07238 1045855007381 proline dipeptidase; Provisional; Region: PRK13607 1045855007382 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1045855007383 active site 1045855007384 glycogen branching enzyme; Provisional; Region: PRK05402 1045855007385 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1045855007386 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1045855007387 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1045855007388 active site 1045855007389 catalytic site [active] 1045855007390 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1045855007391 trehalose synthase; Region: treS_nterm; TIGR02456 1045855007392 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1045855007393 active site 1045855007394 catalytic site [active] 1045855007395 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1045855007396 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1045855007397 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1045855007398 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1045855007399 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1045855007400 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1045855007401 active site 1045855007402 homodimer interface [polypeptide binding]; other site 1045855007403 catalytic site [active] 1045855007404 acceptor binding site [chemical binding]; other site 1045855007405 proline aminopeptidase P II; Provisional; Region: PRK10879 1045855007406 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1045855007407 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1045855007408 active site 1045855007409 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1045855007410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1045855007411 PAS fold; Region: PAS_3; pfam08447 1045855007412 heme pocket [chemical binding]; other site 1045855007413 putative active site [active] 1045855007414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045855007415 PAS domain; Region: PAS_9; pfam13426 1045855007416 putative active site [active] 1045855007417 heme pocket [chemical binding]; other site 1045855007418 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855007419 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855007420 metal binding site [ion binding]; metal-binding site 1045855007421 active site 1045855007422 I-site; other site 1045855007423 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045855007424 TIGR02449 family protein; Region: TIGR02449 1045855007425 Cell division protein ZapA; Region: ZapA; pfam05164 1045855007426 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1045855007427 EVE domain; Region: EVE; cl00728 1045855007428 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1045855007429 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045855007430 active site 1045855007431 dimer interface [polypeptide binding]; other site 1045855007432 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1045855007433 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1045855007434 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1045855007435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045855007436 binding surface 1045855007437 TPR motif; other site 1045855007438 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1045855007439 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1045855007440 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1045855007441 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1045855007442 putative acyl-acceptor binding pocket; other site 1045855007443 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 1045855007444 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1045855007445 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1045855007446 putative acyl-acceptor binding pocket; other site 1045855007447 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1045855007448 O-Antigen ligase; Region: Wzy_C; pfam04932 1045855007449 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1045855007450 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1045855007451 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1045855007452 Zinc-finger domain; Region: zf-CHCC; cl01821 1045855007453 acetylornithine transaminase protein; Provisional; Region: argD; PRK04612 1045855007454 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045855007455 inhibitor-cofactor binding pocket; inhibition site 1045855007456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855007457 catalytic residue [active] 1045855007458 Ion transport protein; Region: Ion_trans; pfam00520 1045855007459 Ion channel; Region: Ion_trans_2; pfam07885 1045855007460 short chain dehydrogenase; Provisional; Region: PRK08278 1045855007461 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1045855007462 NAD(P) binding site [chemical binding]; other site 1045855007463 homodimer interface [polypeptide binding]; other site 1045855007464 active site 1045855007465 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1045855007466 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1045855007467 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1045855007468 active site 1045855007469 LssY C-terminus; Region: LssY_C; pfam14067 1045855007470 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1045855007471 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045855007472 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1045855007473 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045855007474 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045855007475 adenylate kinase; Reviewed; Region: adk; PRK00279 1045855007476 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1045855007477 AMP-binding site [chemical binding]; other site 1045855007478 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1045855007479 6-phosphofructokinase; Provisional; Region: PRK14072 1045855007480 active site 1045855007481 ADP/pyrophosphate binding site [chemical binding]; other site 1045855007482 allosteric effector site; other site 1045855007483 dimerization interface [polypeptide binding]; other site 1045855007484 fructose-1,6-bisphosphate binding site; other site 1045855007485 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1045855007486 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1045855007487 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1045855007488 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1045855007489 dimer interface [polypeptide binding]; other site 1045855007490 substrate binding site [chemical binding]; other site 1045855007491 metal binding sites [ion binding]; metal-binding site 1045855007492 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1045855007493 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1045855007494 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1045855007495 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1045855007496 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1045855007497 PYR/PP interface [polypeptide binding]; other site 1045855007498 dimer interface [polypeptide binding]; other site 1045855007499 TPP binding site [chemical binding]; other site 1045855007500 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045855007501 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1045855007502 TPP-binding site [chemical binding]; other site 1045855007503 dimer interface [polypeptide binding]; other site 1045855007504 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1045855007505 2-isopropylmalate synthase; Validated; Region: PRK00915 1045855007506 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1045855007507 active site 1045855007508 catalytic residues [active] 1045855007509 metal binding site [ion binding]; metal-binding site 1045855007510 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1045855007511 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1045855007512 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1045855007513 substrate binding site [chemical binding]; other site 1045855007514 ligand binding site [chemical binding]; other site 1045855007515 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1045855007516 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1045855007517 substrate binding site [chemical binding]; other site 1045855007518 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1045855007519 tartrate dehydrogenase; Region: TTC; TIGR02089 1045855007520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045855007521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855007522 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1045855007523 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1045855007524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855007525 S-adenosylmethionine binding site [chemical binding]; other site 1045855007526 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1045855007527 PAS fold; Region: PAS_4; pfam08448 1045855007528 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045855007529 putative active site [active] 1045855007530 heme pocket [chemical binding]; other site 1045855007531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1045855007532 dimer interface [polypeptide binding]; other site 1045855007533 phosphorylation site [posttranslational modification] 1045855007534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855007535 ATP binding site [chemical binding]; other site 1045855007536 Mg2+ binding site [ion binding]; other site 1045855007537 G-X-G motif; other site 1045855007538 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855007539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855007540 active site 1045855007541 phosphorylation site [posttranslational modification] 1045855007542 intermolecular recognition site; other site 1045855007543 dimerization interface [polypeptide binding]; other site 1045855007544 Cache domain; Region: Cache_1; pfam02743 1045855007545 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855007546 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855007547 metal binding site [ion binding]; metal-binding site 1045855007548 active site 1045855007549 I-site; other site 1045855007550 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1045855007551 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1045855007552 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855007553 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855007554 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045855007555 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045855007556 DNA binding site [nucleotide binding] 1045855007557 domain linker motif; other site 1045855007558 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1045855007559 dimerization interface [polypeptide binding]; other site 1045855007560 ligand binding site [chemical binding]; other site 1045855007561 alanine racemase; Reviewed; Region: dadX; PRK03646 1045855007562 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1045855007563 active site 1045855007564 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045855007565 substrate binding site [chemical binding]; other site 1045855007566 catalytic residues [active] 1045855007567 dimer interface [polypeptide binding]; other site 1045855007568 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1045855007569 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1045855007570 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 1045855007571 Domain of unknown function (DUF802); Region: DUF802; pfam05650 1045855007572 hypothetical protein; Provisional; Region: PRK09040 1045855007573 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045855007574 ligand binding site [chemical binding]; other site 1045855007575 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 1045855007576 Flavin Reductases; Region: FlaRed; cl00801 1045855007577 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1045855007578 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1045855007579 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1045855007580 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1045855007581 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1045855007582 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1045855007583 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1045855007584 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1045855007585 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1045855007586 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1045855007587 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1045855007588 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1045855007589 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045855007590 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1045855007591 putative molybdopterin cofactor binding site; other site 1045855007592 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045855007593 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045855007594 molybdopterin cofactor binding site; other site 1045855007595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855007596 short chain dehydrogenase; Provisional; Region: PRK06701 1045855007597 NAD(P) binding site [chemical binding]; other site 1045855007598 active site 1045855007599 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1045855007600 putative catalytic site [active] 1045855007601 putative phosphate binding site [ion binding]; other site 1045855007602 active site 1045855007603 metal binding site A [ion binding]; metal-binding site 1045855007604 DNA binding site [nucleotide binding] 1045855007605 putative AP binding site [nucleotide binding]; other site 1045855007606 putative metal binding site B [ion binding]; other site 1045855007607 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1045855007608 heme binding pocket [chemical binding]; other site 1045855007609 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1045855007610 Hemerythrin-like domain; Region: Hr-like; cd12108 1045855007611 Fe binding site [ion binding]; other site 1045855007612 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1045855007613 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1045855007614 Walker A/P-loop; other site 1045855007615 ATP binding site [chemical binding]; other site 1045855007616 Q-loop/lid; other site 1045855007617 ABC transporter signature motif; other site 1045855007618 Walker B; other site 1045855007619 D-loop; other site 1045855007620 H-loop/switch region; other site 1045855007621 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1045855007622 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1045855007623 Walker A/P-loop; other site 1045855007624 ATP binding site [chemical binding]; other site 1045855007625 Q-loop/lid; other site 1045855007626 ABC transporter signature motif; other site 1045855007627 Walker B; other site 1045855007628 D-loop; other site 1045855007629 H-loop/switch region; other site 1045855007630 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1045855007631 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1045855007632 TM-ABC transporter signature motif; other site 1045855007633 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1045855007634 TM-ABC transporter signature motif; other site 1045855007635 Porin subfamily; Region: Porin_2; pfam02530 1045855007636 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1045855007637 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1045855007638 putative ligand binding site [chemical binding]; other site 1045855007639 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1045855007640 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1045855007641 putative ligand binding site [chemical binding]; other site 1045855007642 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1045855007643 CoenzymeA binding site [chemical binding]; other site 1045855007644 subunit interaction site [polypeptide binding]; other site 1045855007645 PHB binding site; other site 1045855007646 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1045855007647 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045855007648 acyl-activating enzyme (AAE) consensus motif; other site 1045855007649 AMP binding site [chemical binding]; other site 1045855007650 active site 1045855007651 CoA binding site [chemical binding]; other site 1045855007652 DUF35 OB-fold domain; Region: DUF35; pfam01796 1045855007653 thiolase; Provisional; Region: PRK06158 1045855007654 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1045855007655 active site 1045855007656 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1045855007657 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1045855007658 [2Fe-2S] cluster binding site [ion binding]; other site 1045855007659 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1045855007660 putative alpha subunit interface [polypeptide binding]; other site 1045855007661 putative active site [active] 1045855007662 putative substrate binding site [chemical binding]; other site 1045855007663 Fe binding site [ion binding]; other site 1045855007664 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1045855007665 classical (c) SDRs; Region: SDR_c; cd05233 1045855007666 NAD(P) binding site [chemical binding]; other site 1045855007667 active site 1045855007668 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1045855007669 TSCPD domain; Region: TSCPD; pfam12637 1045855007670 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1045855007671 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1045855007672 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1045855007673 active site 1045855007674 dimer interface [polypeptide binding]; other site 1045855007675 effector binding site; other site 1045855007676 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1045855007677 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1045855007678 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1045855007679 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045855007680 protein binding site [polypeptide binding]; other site 1045855007681 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1045855007682 protein binding site [polypeptide binding]; other site 1045855007683 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1045855007684 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1045855007685 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1045855007686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855007687 motif II; other site 1045855007688 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1045855007689 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1045855007690 interface (dimer of trimers) [polypeptide binding]; other site 1045855007691 Substrate-binding/catalytic site; other site 1045855007692 Zn-binding sites [ion binding]; other site 1045855007693 CHASE3 domain; Region: CHASE3; pfam05227 1045855007694 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045855007695 GAF domain; Region: GAF_3; pfam13492 1045855007696 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855007697 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855007698 metal binding site [ion binding]; metal-binding site 1045855007699 active site 1045855007700 I-site; other site 1045855007701 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045855007702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855007703 active site 1045855007704 phosphorylation site [posttranslational modification] 1045855007705 intermolecular recognition site; other site 1045855007706 dimerization interface [polypeptide binding]; other site 1045855007707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045855007708 DNA binding residues [nucleotide binding] 1045855007709 dimerization interface [polypeptide binding]; other site 1045855007710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1045855007711 Histidine kinase; Region: HisKA_3; pfam07730 1045855007712 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045855007713 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1045855007714 Walker A/P-loop; other site 1045855007715 ATP binding site [chemical binding]; other site 1045855007716 Q-loop/lid; other site 1045855007717 ABC transporter signature motif; other site 1045855007718 Walker B; other site 1045855007719 D-loop; other site 1045855007720 H-loop/switch region; other site 1045855007721 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1045855007722 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045855007723 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855007724 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1045855007725 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045855007726 Walker A/P-loop; other site 1045855007727 ATP binding site [chemical binding]; other site 1045855007728 Q-loop/lid; other site 1045855007729 ABC transporter signature motif; other site 1045855007730 Walker B; other site 1045855007731 D-loop; other site 1045855007732 H-loop/switch region; other site 1045855007733 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045855007734 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1045855007735 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1045855007736 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045855007737 FtsX-like permease family; Region: FtsX; pfam02687 1045855007738 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045855007739 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1045855007740 Ligand binding site; other site 1045855007741 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1045855007742 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1045855007743 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1045855007744 EamA-like transporter family; Region: EamA; pfam00892 1045855007745 carboxy-terminal protease; Provisional; Region: PRK11186 1045855007746 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1045855007747 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1045855007748 protein binding site [polypeptide binding]; other site 1045855007749 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1045855007750 Catalytic dyad [active] 1045855007751 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1045855007752 lipoyl synthase; Provisional; Region: PRK05481 1045855007753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045855007754 FeS/SAM binding site; other site 1045855007755 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1045855007756 active site 1045855007757 catalytic residues [active] 1045855007758 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1045855007759 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1045855007760 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1045855007761 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1045855007762 ring oligomerisation interface [polypeptide binding]; other site 1045855007763 ATP/Mg binding site [chemical binding]; other site 1045855007764 stacking interactions; other site 1045855007765 hinge regions; other site 1045855007766 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1045855007767 oligomerisation interface [polypeptide binding]; other site 1045855007768 mobile loop; other site 1045855007769 roof hairpin; other site 1045855007770 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1045855007771 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1045855007772 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1045855007773 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1045855007774 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045855007775 DsbD alpha interface [polypeptide binding]; other site 1045855007776 catalytic residues [active] 1045855007777 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1045855007778 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045855007779 catalytic residues [active] 1045855007780 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1045855007781 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1045855007782 carboxyltransferase (CT) interaction site; other site 1045855007783 biotinylation site [posttranslational modification]; other site 1045855007784 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1045855007785 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045855007786 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1045855007787 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1045855007788 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1045855007789 putative active site [active] 1045855007790 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1045855007791 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1045855007792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855007793 NAD(P) binding site [chemical binding]; other site 1045855007794 active site 1045855007795 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1045855007796 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1045855007797 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1045855007798 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1045855007799 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1045855007800 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1045855007801 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1045855007802 purine monophosphate binding site [chemical binding]; other site 1045855007803 dimer interface [polypeptide binding]; other site 1045855007804 putative catalytic residues [active] 1045855007805 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1045855007806 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1045855007807 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1045855007808 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1045855007809 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1045855007810 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1045855007811 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1045855007812 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1045855007813 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1045855007814 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1045855007815 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1045855007816 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045855007817 classical (c) SDRs; Region: SDR_c; cd05233 1045855007818 NAD(P) binding site [chemical binding]; other site 1045855007819 active site 1045855007820 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1045855007821 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855007822 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1045855007823 putative active site [active] 1045855007824 putative metal binding site [ion binding]; other site 1045855007825 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1045855007826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855007827 putative substrate translocation pore; other site 1045855007828 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1045855007829 putative acyl-acceptor binding pocket; other site 1045855007830 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1045855007831 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1045855007832 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1045855007833 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 1045855007834 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1045855007835 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1045855007836 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1045855007837 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1045855007838 putative NADH binding site [chemical binding]; other site 1045855007839 putative active site [active] 1045855007840 nudix motif; other site 1045855007841 putative metal binding site [ion binding]; other site 1045855007842 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1045855007843 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 1045855007844 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855007845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855007846 active site 1045855007847 phosphorylation site [posttranslational modification] 1045855007848 intermolecular recognition site; other site 1045855007849 dimerization interface [polypeptide binding]; other site 1045855007850 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045855007851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855007852 dimer interface [polypeptide binding]; other site 1045855007853 phosphorylation site [posttranslational modification] 1045855007854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855007855 ATP binding site [chemical binding]; other site 1045855007856 Mg2+ binding site [ion binding]; other site 1045855007857 G-X-G motif; other site 1045855007858 Response regulator receiver domain; Region: Response_reg; pfam00072 1045855007859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855007860 active site 1045855007861 phosphorylation site [posttranslational modification] 1045855007862 intermolecular recognition site; other site 1045855007863 dimerization interface [polypeptide binding]; other site 1045855007864 Hpt domain; Region: Hpt; pfam01627 1045855007865 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1045855007866 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1045855007867 heme binding site [chemical binding]; other site 1045855007868 ferroxidase pore; other site 1045855007869 ferroxidase diiron center [ion binding]; other site 1045855007870 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1045855007871 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1045855007872 putative active site [active] 1045855007873 Ap4A binding site [chemical binding]; other site 1045855007874 nudix motif; other site 1045855007875 putative metal binding site [ion binding]; other site 1045855007876 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1045855007877 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1045855007878 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1045855007879 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1045855007880 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1045855007881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855007882 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1045855007883 Walker A/P-loop; other site 1045855007884 ATP binding site [chemical binding]; other site 1045855007885 Q-loop/lid; other site 1045855007886 ABC transporter signature motif; other site 1045855007887 Walker B; other site 1045855007888 D-loop; other site 1045855007889 H-loop/switch region; other site 1045855007890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855007891 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1045855007892 Walker A/P-loop; other site 1045855007893 ATP binding site [chemical binding]; other site 1045855007894 Q-loop/lid; other site 1045855007895 ABC transporter signature motif; other site 1045855007896 Walker B; other site 1045855007897 D-loop; other site 1045855007898 H-loop/switch region; other site 1045855007899 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045855007900 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045855007901 ligand binding site [chemical binding]; other site 1045855007902 flexible hinge region; other site 1045855007903 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1045855007904 putative switch regulator; other site 1045855007905 non-specific DNA interactions [nucleotide binding]; other site 1045855007906 DNA binding site [nucleotide binding] 1045855007907 sequence specific DNA binding site [nucleotide binding]; other site 1045855007908 putative cAMP binding site [chemical binding]; other site 1045855007909 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1045855007910 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1045855007911 ATP binding site [chemical binding]; other site 1045855007912 Mg++ binding site [ion binding]; other site 1045855007913 motif III; other site 1045855007914 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855007915 nucleotide binding region [chemical binding]; other site 1045855007916 ATP-binding site [chemical binding]; other site 1045855007917 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1045855007918 active site 1045855007919 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1045855007920 GAF domain; Region: GAF_2; pfam13185 1045855007921 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1045855007922 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 1045855007923 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1045855007924 N-terminal plug; other site 1045855007925 ligand-binding site [chemical binding]; other site 1045855007926 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1045855007927 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1045855007928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855007929 motif II; other site 1045855007930 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1045855007931 active site 1045855007932 DNA polymerase IV; Validated; Region: PRK02406 1045855007933 DNA binding site [nucleotide binding] 1045855007934 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1045855007935 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1045855007936 Ca2+ binding site [ion binding]; other site 1045855007937 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1045855007938 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1045855007939 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1045855007940 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1045855007941 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1045855007942 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 1045855007943 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1045855007944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855007945 NAD(P) binding site [chemical binding]; other site 1045855007946 active site 1045855007947 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1045855007948 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1045855007949 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1045855007950 active site 1045855007951 catalytic site [active] 1045855007952 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1045855007953 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1045855007954 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1045855007955 active site 1045855007956 catalytic site [active] 1045855007957 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1045855007958 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1045855007959 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1045855007960 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1045855007961 catalytic site [active] 1045855007962 active site 1045855007963 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1045855007964 glycogen branching enzyme; Provisional; Region: PRK05402 1045855007965 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1045855007966 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1045855007967 active site 1045855007968 catalytic site [active] 1045855007969 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1045855007970 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1045855007971 glycogen synthase; Provisional; Region: glgA; PRK00654 1045855007972 ADP-binding pocket [chemical binding]; other site 1045855007973 homodimer interface [polypeptide binding]; other site 1045855007974 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1045855007975 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1045855007976 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1045855007977 [2Fe-2S] cluster binding site [ion binding]; other site 1045855007978 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1045855007979 hydrophobic ligand binding site; other site 1045855007980 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1045855007981 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1045855007982 active site 1045855007983 nucleophile elbow; other site 1045855007984 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1045855007985 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1045855007986 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1045855007987 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1045855007988 dinuclear metal binding motif [ion binding]; other site 1045855007989 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1045855007990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045855007991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855007992 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1045855007993 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1045855007994 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1045855007995 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045855007996 Winged helix-turn helix; Region: HTH_33; pfam13592 1045855007997 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1045855007998 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1045855007999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1045855008000 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1045855008001 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1045855008002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1045855008003 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1045855008004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1045855008005 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1045855008006 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1045855008007 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1045855008008 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1045855008009 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1045855008010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045855008011 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1045855008012 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1045855008013 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1045855008014 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1045855008015 active site 1045855008016 metal binding site [ion binding]; metal-binding site 1045855008017 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1045855008018 dimer interface [polypeptide binding]; other site 1045855008019 tetramer interface [polypeptide binding]; other site 1045855008020 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1045855008021 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1045855008022 iron-sulfur cluster [ion binding]; other site 1045855008023 [2Fe-2S] cluster binding site [ion binding]; other site 1045855008024 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1045855008025 alpha subunit interface [polypeptide binding]; other site 1045855008026 active site 1045855008027 substrate binding site [chemical binding]; other site 1045855008028 Fe binding site [ion binding]; other site 1045855008029 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1045855008030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045855008031 DNA-binding site [nucleotide binding]; DNA binding site 1045855008032 FCD domain; Region: FCD; pfam07729 1045855008033 Helix-turn-helix domain; Region: HTH_18; pfam12833 1045855008034 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1045855008035 [2Fe-2S] cluster binding site [ion binding]; other site 1045855008036 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1045855008037 inter-subunit interface; other site 1045855008038 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1045855008039 iron-sulfur cluster [ion binding]; other site 1045855008040 [2Fe-2S] cluster binding site [ion binding]; other site 1045855008041 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 1045855008042 putative alpha subunit interface [polypeptide binding]; other site 1045855008043 putative active site [active] 1045855008044 putative substrate binding site [chemical binding]; other site 1045855008045 Fe binding site [ion binding]; other site 1045855008046 PAS fold; Region: PAS_4; pfam08448 1045855008047 PAS fold; Region: PAS_4; pfam08448 1045855008048 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045855008049 GAF domain; Region: GAF; pfam01590 1045855008050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855008051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855008052 dimer interface [polypeptide binding]; other site 1045855008053 phosphorylation site [posttranslational modification] 1045855008054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855008055 ATP binding site [chemical binding]; other site 1045855008056 Mg2+ binding site [ion binding]; other site 1045855008057 G-X-G motif; other site 1045855008058 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045855008059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855008060 active site 1045855008061 phosphorylation site [posttranslational modification] 1045855008062 intermolecular recognition site; other site 1045855008063 dimerization interface [polypeptide binding]; other site 1045855008064 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1045855008065 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1045855008066 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1045855008067 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1045855008068 active site 1045855008069 Zn binding site [ion binding]; other site 1045855008070 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1045855008071 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1045855008072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855008073 catalytic residue [active] 1045855008074 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045855008075 GAF domain; Region: GAF; pfam01590 1045855008076 PAS domain S-box; Region: sensory_box; TIGR00229 1045855008077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045855008078 putative active site [active] 1045855008079 heme pocket [chemical binding]; other site 1045855008080 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855008081 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855008082 metal binding site [ion binding]; metal-binding site 1045855008083 active site 1045855008084 I-site; other site 1045855008085 aldehyde dehydrogenase family 7 member; Region: PLN02315 1045855008086 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1045855008087 tetrameric interface [polypeptide binding]; other site 1045855008088 NAD binding site [chemical binding]; other site 1045855008089 catalytic residues [active] 1045855008090 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1045855008091 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1045855008092 glutaminase active site [active] 1045855008093 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1045855008094 dimer interface [polypeptide binding]; other site 1045855008095 active site 1045855008096 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1045855008097 dimer interface [polypeptide binding]; other site 1045855008098 active site 1045855008099 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1045855008100 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045855008101 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045855008102 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1045855008103 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045855008104 Walker A/P-loop; other site 1045855008105 ATP binding site [chemical binding]; other site 1045855008106 Q-loop/lid; other site 1045855008107 ABC transporter signature motif; other site 1045855008108 Walker B; other site 1045855008109 D-loop; other site 1045855008110 H-loop/switch region; other site 1045855008111 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045855008112 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1045855008113 FtsX-like permease family; Region: FtsX; pfam02687 1045855008114 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045855008115 FtsX-like permease family; Region: FtsX; pfam02687 1045855008116 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045855008117 FtsX-like permease family; Region: FtsX; pfam02687 1045855008118 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045855008119 FtsX-like permease family; Region: FtsX; pfam02687 1045855008120 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1045855008121 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1045855008122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855008123 active site 1045855008124 phosphorylation site [posttranslational modification] 1045855008125 intermolecular recognition site; other site 1045855008126 dimerization interface [polypeptide binding]; other site 1045855008127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855008128 Walker A motif; other site 1045855008129 ATP binding site [chemical binding]; other site 1045855008130 Walker B motif; other site 1045855008131 arginine finger; other site 1045855008132 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1045855008133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855008134 ATP binding site [chemical binding]; other site 1045855008135 Mg2+ binding site [ion binding]; other site 1045855008136 G-X-G motif; other site 1045855008137 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1045855008138 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1045855008139 Substrate binding site; other site 1045855008140 Mg++ binding site; other site 1045855008141 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1045855008142 active site 1045855008143 substrate binding site [chemical binding]; other site 1045855008144 CoA binding site [chemical binding]; other site 1045855008145 Predicted membrane protein [Function unknown]; Region: COG2246 1045855008146 GtrA-like protein; Region: GtrA; pfam04138 1045855008147 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1045855008148 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1045855008149 gamma subunit interface [polypeptide binding]; other site 1045855008150 epsilon subunit interface [polypeptide binding]; other site 1045855008151 LBP interface [polypeptide binding]; other site 1045855008152 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1045855008153 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1045855008154 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1045855008155 alpha subunit interaction interface [polypeptide binding]; other site 1045855008156 Walker A motif; other site 1045855008157 ATP binding site [chemical binding]; other site 1045855008158 Walker B motif; other site 1045855008159 inhibitor binding site; inhibition site 1045855008160 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1045855008161 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1045855008162 core domain interface [polypeptide binding]; other site 1045855008163 delta subunit interface [polypeptide binding]; other site 1045855008164 epsilon subunit interface [polypeptide binding]; other site 1045855008165 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1045855008166 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1045855008167 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1045855008168 beta subunit interaction interface [polypeptide binding]; other site 1045855008169 Walker A motif; other site 1045855008170 ATP binding site [chemical binding]; other site 1045855008171 Walker B motif; other site 1045855008172 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1045855008173 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1045855008174 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1045855008175 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1045855008176 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1045855008177 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1045855008178 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1045855008179 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1045855008180 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1045855008181 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045855008182 E3 interaction surface; other site 1045855008183 lipoyl attachment site [posttranslational modification]; other site 1045855008184 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045855008185 E3 interaction surface; other site 1045855008186 lipoyl attachment site [posttranslational modification]; other site 1045855008187 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1045855008188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045855008189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045855008190 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1045855008191 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1045855008192 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045855008193 E3 interaction surface; other site 1045855008194 lipoyl attachment site [posttranslational modification]; other site 1045855008195 e3 binding domain; Region: E3_binding; pfam02817 1045855008196 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1045855008197 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1045855008198 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1045855008199 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1045855008200 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1045855008201 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1045855008202 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1045855008203 active site 1045855008204 homotetramer interface [polypeptide binding]; other site 1045855008205 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1045855008206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1045855008207 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1045855008208 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1045855008209 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1045855008210 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1045855008211 beta-alpha-beta structure motif; other site 1045855008212 NAD binding pocket [chemical binding]; other site 1045855008213 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1045855008214 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1045855008215 Di-iron ligands [ion binding]; other site 1045855008216 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1045855008217 hydrophobic ligand binding site; other site 1045855008218 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1045855008219 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1045855008220 catalytic Zn binding site [ion binding]; other site 1045855008221 NAD binding site [chemical binding]; other site 1045855008222 structural Zn binding site [ion binding]; other site 1045855008223 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1045855008224 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 1045855008225 NAD(P) binding site [chemical binding]; other site 1045855008226 catalytic residues [active] 1045855008227 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1045855008228 iron-sulfur cluster [ion binding]; other site 1045855008229 [2Fe-2S] cluster binding site [ion binding]; other site 1045855008230 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 1045855008231 putative alpha subunit interface [polypeptide binding]; other site 1045855008232 putative active site [active] 1045855008233 putative substrate binding site [chemical binding]; other site 1045855008234 Fe binding site [ion binding]; other site 1045855008235 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1045855008236 inter-subunit interface; other site 1045855008237 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1045855008238 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1045855008239 Walker A/P-loop; other site 1045855008240 ATP binding site [chemical binding]; other site 1045855008241 Q-loop/lid; other site 1045855008242 ABC transporter signature motif; other site 1045855008243 Walker B; other site 1045855008244 D-loop; other site 1045855008245 H-loop/switch region; other site 1045855008246 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1045855008247 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1045855008248 Walker A/P-loop; other site 1045855008249 ATP binding site [chemical binding]; other site 1045855008250 Q-loop/lid; other site 1045855008251 ABC transporter signature motif; other site 1045855008252 Walker B; other site 1045855008253 D-loop; other site 1045855008254 H-loop/switch region; other site 1045855008255 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045855008256 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1045855008257 TM-ABC transporter signature motif; other site 1045855008258 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045855008259 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1045855008260 TM-ABC transporter signature motif; other site 1045855008261 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1045855008262 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 1045855008263 putative ligand binding site [chemical binding]; other site 1045855008264 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1045855008265 [2Fe-2S] cluster binding site [ion binding]; other site 1045855008266 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1045855008267 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1045855008268 trimer interface [polypeptide binding]; other site 1045855008269 eyelet of channel; other site 1045855008270 Benzoate membrane transport protein; Region: BenE; pfam03594 1045855008271 benzoate transporter; Region: benE; TIGR00843 1045855008272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855008273 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1045855008274 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1045855008275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855008276 NAD(P) binding site [chemical binding]; other site 1045855008277 active site 1045855008278 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1045855008279 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045855008280 catalytic loop [active] 1045855008281 iron binding site [ion binding]; other site 1045855008282 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1045855008283 FAD binding pocket [chemical binding]; other site 1045855008284 FAD binding motif [chemical binding]; other site 1045855008285 phosphate binding motif [ion binding]; other site 1045855008286 beta-alpha-beta structure motif; other site 1045855008287 NAD binding pocket [chemical binding]; other site 1045855008288 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1045855008289 inter-subunit interface; other site 1045855008290 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1045855008291 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1045855008292 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1045855008293 putative alpha subunit interface [polypeptide binding]; other site 1045855008294 putative active site [active] 1045855008295 putative substrate binding site [chemical binding]; other site 1045855008296 Fe binding site [ion binding]; other site 1045855008297 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1045855008298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855008299 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 1045855008300 dimerizarion interface [polypeptide binding]; other site 1045855008301 CrgA pocket; other site 1045855008302 substrate binding pocket [chemical binding]; other site 1045855008303 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 1045855008304 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045855008305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855008306 NAD(P) binding site [chemical binding]; other site 1045855008307 active site 1045855008308 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1045855008309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045855008310 motif II; other site 1045855008311 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1045855008312 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1045855008313 active site 1045855008314 uracil binding [chemical binding]; other site 1045855008315 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1045855008316 Methyltransferase small domain; Region: MTS; pfam05175 1045855008317 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1045855008318 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1045855008319 ABC1 family; Region: ABC1; cl17513 1045855008320 ABC1 family; Region: ABC1; cl17513 1045855008321 FtsX-like permease family; Region: FtsX; pfam02687 1045855008322 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1045855008323 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045855008324 Walker A/P-loop; other site 1045855008325 ATP binding site [chemical binding]; other site 1045855008326 Q-loop/lid; other site 1045855008327 ABC transporter signature motif; other site 1045855008328 Walker B; other site 1045855008329 D-loop; other site 1045855008330 H-loop/switch region; other site 1045855008331 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1045855008332 active site 1045855008333 catalytic triad [active] 1045855008334 oxyanion hole [active] 1045855008335 switch loop; other site 1045855008336 Protein of unknown function (DUF3247); Region: DUF3247; pfam11607 1045855008337 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1045855008338 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1045855008339 catalytic residues [active] 1045855008340 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1045855008341 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1045855008342 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1045855008343 active site 1045855008344 DNA binding site [nucleotide binding] 1045855008345 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1045855008346 DNA binding site [nucleotide binding] 1045855008347 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1045855008348 nucleotide binding site [chemical binding]; other site 1045855008349 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1045855008350 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1045855008351 putative DNA binding site [nucleotide binding]; other site 1045855008352 putative homodimer interface [polypeptide binding]; other site 1045855008353 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1045855008354 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 1045855008355 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1045855008356 SelR domain; Region: SelR; pfam01641 1045855008357 SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; Region: SPARC_EC; cd00252 1045855008358 EF-hand Ca2+ binding loops [ion binding]; other site 1045855008359 FS-domain interface [polypeptide binding]; other site 1045855008360 putative K+ binding site [ion binding]; other site 1045855008361 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1045855008362 EF-hand domain pair; Region: EF_hand_5; pfam13499 1045855008363 Ca2+ binding site [ion binding]; other site 1045855008364 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1045855008365 Ca2+ binding site [ion binding]; other site 1045855008366 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1045855008367 EF-hand domain pair; Region: EF_hand_5; pfam13499 1045855008368 Ca2+ binding site [ion binding]; other site 1045855008369 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 1045855008370 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 1045855008371 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1045855008372 PAS fold; Region: PAS_3; pfam08447 1045855008373 PAS domain S-box; Region: sensory_box; TIGR00229 1045855008374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045855008375 putative active site [active] 1045855008376 heme pocket [chemical binding]; other site 1045855008377 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855008378 metal binding site [ion binding]; metal-binding site 1045855008379 active site 1045855008380 I-site; other site 1045855008381 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1045855008382 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1045855008383 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045855008384 active site 1045855008385 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1045855008386 FAD dependent oxidoreductase; Region: DAO; pfam01266 1045855008387 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1045855008388 active site 1045855008389 catalytic residues [active] 1045855008390 DNA ligase; Provisional; Region: PRK09125 1045855008391 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 1045855008392 DNA binding site [nucleotide binding] 1045855008393 active site 1045855008394 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 1045855008395 DNA binding site [nucleotide binding] 1045855008396 Trehalase; Region: Trehalase; cl17346 1045855008397 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1045855008398 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045855008399 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1045855008400 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 1045855008401 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 1045855008402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855008403 S-adenosylmethionine binding site [chemical binding]; other site 1045855008404 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1045855008405 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1045855008406 putative acyl-acceptor binding pocket; other site 1045855008407 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1045855008408 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708 1045855008409 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1045855008410 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1045855008411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855008412 S-adenosylmethionine binding site [chemical binding]; other site 1045855008413 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1045855008414 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1045855008415 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1045855008416 putative NAD(P) binding site [chemical binding]; other site 1045855008417 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1045855008418 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1045855008419 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045855008420 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1045855008421 phosphoglycerol transferase I; Provisional; Region: PRK12363 1045855008422 Sulfatase; Region: Sulfatase; cl17466 1045855008423 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1045855008424 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 1045855008425 putative acyl-acceptor binding pocket; other site 1045855008426 hypothetical protein; Provisional; Region: PRK09256 1045855008427 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1045855008428 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1045855008429 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1045855008430 ligand binding site [chemical binding]; other site 1045855008431 active site 1045855008432 UGI interface [polypeptide binding]; other site 1045855008433 catalytic site [active] 1045855008434 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1045855008435 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1045855008436 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1045855008437 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1045855008438 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 1045855008439 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 1045855008440 CRISPR-associated protein Cas7/Csd2, subtype I-C/DVULG; Region: cas_Csd2; TIGR02589 1045855008441 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 1045855008442 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1045855008443 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1045855008444 UGMP family protein; Validated; Region: PRK09604 1045855008445 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1045855008446 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1045855008447 Yqey-like protein; Region: YqeY; pfam09424 1045855008448 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1045855008449 DNA primase; Validated; Region: dnaG; PRK05667 1045855008450 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1045855008451 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1045855008452 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1045855008453 active site 1045855008454 metal binding site [ion binding]; metal-binding site 1045855008455 interdomain interaction site; other site 1045855008456 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1045855008457 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1045855008458 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1045855008459 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1045855008460 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045855008461 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1045855008462 DNA binding site [nucleotide binding] 1045855008463 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1045855008464 putative ligand binding site [chemical binding]; other site 1045855008465 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1045855008466 UbiA prenyltransferase family; Region: UbiA; pfam01040 1045855008467 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1045855008468 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1045855008469 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1045855008470 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1045855008471 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1045855008472 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1045855008473 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1045855008474 Subunit III/VIIa interface [polypeptide binding]; other site 1045855008475 Phospholipid binding site [chemical binding]; other site 1045855008476 Subunit I/III interface [polypeptide binding]; other site 1045855008477 Subunit III/VIb interface [polypeptide binding]; other site 1045855008478 Subunit III/VIa interface; other site 1045855008479 Subunit III/Vb interface [polypeptide binding]; other site 1045855008480 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1045855008481 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1045855008482 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1045855008483 Subunit I/III interface [polypeptide binding]; other site 1045855008484 D-pathway; other site 1045855008485 Subunit I/VIIc interface [polypeptide binding]; other site 1045855008486 Subunit I/IV interface [polypeptide binding]; other site 1045855008487 Subunit I/II interface [polypeptide binding]; other site 1045855008488 Low-spin heme (heme a) binding site [chemical binding]; other site 1045855008489 Subunit I/VIIa interface [polypeptide binding]; other site 1045855008490 Subunit I/VIa interface [polypeptide binding]; other site 1045855008491 Dimer interface; other site 1045855008492 Putative water exit pathway; other site 1045855008493 Binuclear center (heme a3/CuB) [ion binding]; other site 1045855008494 K-pathway; other site 1045855008495 Subunit I/Vb interface [polypeptide binding]; other site 1045855008496 Putative proton exit pathway; other site 1045855008497 Subunit I/VIb interface; other site 1045855008498 Subunit I/VIc interface [polypeptide binding]; other site 1045855008499 Electron transfer pathway; other site 1045855008500 Subunit I/VIIIb interface [polypeptide binding]; other site 1045855008501 Subunit I/VIIb interface [polypeptide binding]; other site 1045855008502 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1045855008503 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1045855008504 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1045855008505 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 1045855008506 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045855008507 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045855008508 metal binding site [ion binding]; metal-binding site 1045855008509 active site 1045855008510 I-site; other site 1045855008511 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1045855008512 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 1045855008513 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1045855008514 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1045855008515 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1045855008516 protein binding site [polypeptide binding]; other site 1045855008517 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1045855008518 Catalytic dyad [active] 1045855008519 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1045855008520 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1045855008521 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045855008522 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1045855008523 phosphoglyceromutase; Provisional; Region: PRK05434 1045855008524 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1045855008525 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 1045855008526 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1045855008527 PA/protease or protease-like domain interface [polypeptide binding]; other site 1045855008528 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 1045855008529 metal binding site [ion binding]; metal-binding site 1045855008530 MAPEG family; Region: MAPEG; cl09190 1045855008531 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1045855008532 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1045855008533 active site 1045855008534 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1045855008535 ABC1 family; Region: ABC1; cl17513 1045855008536 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1045855008537 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1045855008538 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 1045855008539 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045855008540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855008541 NAD(P) binding site [chemical binding]; other site 1045855008542 active site 1045855008543 peptide synthase; Provisional; Region: PRK09274 1045855008544 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 1045855008545 acyl-activating enzyme (AAE) consensus motif; other site 1045855008546 putative AMP binding site [chemical binding]; other site 1045855008547 putative active site [active] 1045855008548 putative CoA binding site [chemical binding]; other site 1045855008549 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1045855008550 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 1045855008551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855008552 Walker A/P-loop; other site 1045855008553 ATP binding site [chemical binding]; other site 1045855008554 haloalkane dehalogenase; Provisional; Region: PRK00870 1045855008555 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1045855008556 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1045855008557 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1045855008558 putative active site [active] 1045855008559 Fic family protein [Function unknown]; Region: COG3177 1045855008560 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1045855008561 Fic/DOC family; Region: Fic; pfam02661 1045855008562 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 1045855008563 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1045855008564 dimer interface [polypeptide binding]; other site 1045855008565 active site 1045855008566 CoA binding pocket [chemical binding]; other site 1045855008567 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1045855008568 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1045855008569 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1045855008570 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1045855008571 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1045855008572 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1045855008573 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1045855008574 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1045855008575 MarR family; Region: MarR; pfam01047 1045855008576 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1045855008577 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1045855008578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045855008579 putative DNA binding site [nucleotide binding]; other site 1045855008580 putative Zn2+ binding site [ion binding]; other site 1045855008581 AsnC family; Region: AsnC_trans_reg; pfam01037 1045855008582 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 1045855008583 Proline dehydrogenase; Region: Pro_dh; cl03282 1045855008584 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1045855008585 Glutamate binding site [chemical binding]; other site 1045855008586 NAD binding site [chemical binding]; other site 1045855008587 catalytic residues [active] 1045855008588 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1045855008589 active site 1 [active] 1045855008590 dimer interface [polypeptide binding]; other site 1045855008591 hexamer interface [polypeptide binding]; other site 1045855008592 active site 2 [active] 1045855008593 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1045855008594 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1045855008595 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1045855008596 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1045855008597 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1045855008598 glutamine binding [chemical binding]; other site 1045855008599 catalytic triad [active] 1045855008600 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1045855008601 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045855008602 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045855008603 catalytic residue [active] 1045855008604 anthranilate synthase component I; Provisional; Region: PRK13565 1045855008605 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1045855008606 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1045855008607 lipid kinase; Reviewed; Region: PRK13054 1045855008608 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1045855008609 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1045855008610 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1045855008611 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1045855008612 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1045855008613 substrate binding site [chemical binding]; other site 1045855008614 hexamer interface [polypeptide binding]; other site 1045855008615 metal binding site [ion binding]; metal-binding site 1045855008616 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1045855008617 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1045855008618 ATP binding site [chemical binding]; other site 1045855008619 active site 1045855008620 substrate binding site [chemical binding]; other site 1045855008621 Protein of unknown function (DUF962); Region: DUF962; cl01879 1045855008622 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1045855008623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855008624 NAD(P) binding site [chemical binding]; other site 1045855008625 active site 1045855008626 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1045855008627 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1045855008628 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1045855008629 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1045855008630 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1045855008631 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1045855008632 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1045855008633 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1045855008634 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1045855008635 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1045855008636 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1045855008637 Protein of unknown function (DUF819); Region: DUF819; cl02317 1045855008638 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1045855008639 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1045855008640 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1045855008641 amidase catalytic site [active] 1045855008642 Zn binding residues [ion binding]; other site 1045855008643 substrate binding site [chemical binding]; other site 1045855008644 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1045855008645 Beta-lactamase; Region: Beta-lactamase; pfam00144 1045855008646 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1045855008647 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855008648 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855008649 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855008650 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1045855008651 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1045855008652 NlpC/P60 family; Region: NLPC_P60; cl17555 1045855008653 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1045855008654 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1045855008655 active site 1045855008656 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045855008657 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045855008658 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045855008659 putative active site [active] 1045855008660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1045855008661 amino acid transporter; Region: 2A0306; TIGR00909 1045855008662 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1045855008663 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1045855008664 putative active site [active] 1045855008665 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1045855008666 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1045855008667 dimer interface [polypeptide binding]; other site 1045855008668 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1045855008669 active site 1045855008670 Fe binding site [ion binding]; other site 1045855008671 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1045855008672 MarR family; Region: MarR_2; pfam12802 1045855008673 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1045855008674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855008675 POT family; Region: PTR2; cl17359 1045855008676 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1045855008677 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1045855008678 generic binding surface I; other site 1045855008679 generic binding surface II; other site 1045855008680 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1045855008681 putative catalytic site [active] 1045855008682 putative metal binding site [ion binding]; other site 1045855008683 putative phosphate binding site [ion binding]; other site 1045855008684 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1045855008685 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1045855008686 TPP-binding site [chemical binding]; other site 1045855008687 tetramer interface [polypeptide binding]; other site 1045855008688 heterodimer interface [polypeptide binding]; other site 1045855008689 phosphorylation loop region [posttranslational modification] 1045855008690 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1045855008691 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1045855008692 alpha subunit interface [polypeptide binding]; other site 1045855008693 TPP binding site [chemical binding]; other site 1045855008694 heterodimer interface [polypeptide binding]; other site 1045855008695 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1045855008696 Src Homology 3 domain superfamily; Region: SH3; cd00174 1045855008697 peptide ligand binding site [polypeptide binding]; other site 1045855008698 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1045855008699 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1045855008700 E3 interaction surface; other site 1045855008701 lipoyl attachment site [posttranslational modification]; other site 1045855008702 e3 binding domain; Region: E3_binding; pfam02817 1045855008703 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1045855008704 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045855008705 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1045855008706 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1045855008707 active site 1045855008708 HIGH motif; other site 1045855008709 dimer interface [polypeptide binding]; other site 1045855008710 KMSKS motif; other site 1045855008711 CsbD-like; Region: CsbD; cl17424 1045855008712 Predicted small secreted protein [Function unknown]; Region: COG5510 1045855008713 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1045855008714 HTH domain; Region: HTH_11; pfam08279 1045855008715 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1045855008716 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1045855008717 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1045855008718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855008719 dimer interface [polypeptide binding]; other site 1045855008720 phosphorylation site [posttranslational modification] 1045855008721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855008722 ATP binding site [chemical binding]; other site 1045855008723 Mg2+ binding site [ion binding]; other site 1045855008724 G-X-G motif; other site 1045855008725 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045855008726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855008727 active site 1045855008728 phosphorylation site [posttranslational modification] 1045855008729 intermolecular recognition site; other site 1045855008730 dimerization interface [polypeptide binding]; other site 1045855008731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855008732 DNA binding site [nucleotide binding] 1045855008733 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 1045855008734 Amidinotransferase; Region: Amidinotransf; cl12043 1045855008735 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1045855008736 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1045855008737 FMN binding site [chemical binding]; other site 1045855008738 active site 1045855008739 catalytic residues [active] 1045855008740 substrate binding site [chemical binding]; other site 1045855008741 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1045855008742 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1045855008743 active site 1045855008744 HIGH motif; other site 1045855008745 dimer interface [polypeptide binding]; other site 1045855008746 KMSKS motif; other site 1045855008747 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1045855008748 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045855008749 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045855008750 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1045855008751 D-lactate dehydrogenase; Provisional; Region: PRK11183 1045855008752 FAD binding domain; Region: FAD_binding_4; pfam01565 1045855008753 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1045855008754 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1045855008755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1045855008756 dimer interface [polypeptide binding]; other site 1045855008757 active site 1045855008758 metal binding site [ion binding]; metal-binding site 1045855008759 glutathione binding site [chemical binding]; other site 1045855008760 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1045855008761 muropeptide transporter; Validated; Region: ampG; cl17669 1045855008762 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1045855008763 putative active site [active] 1045855008764 putative catalytic site [active] 1045855008765 putative DNA binding site [nucleotide binding]; other site 1045855008766 putative phosphate binding site [ion binding]; other site 1045855008767 metal binding site A [ion binding]; metal-binding site 1045855008768 putative AP binding site [nucleotide binding]; other site 1045855008769 putative metal binding site B [ion binding]; other site 1045855008770 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1045855008771 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045855008772 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1045855008773 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1045855008774 active site 1045855008775 substrate binding site [chemical binding]; other site 1045855008776 metal binding site [ion binding]; metal-binding site 1045855008777 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1045855008778 trimer interface [polypeptide binding]; other site 1045855008779 active site 1045855008780 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1045855008781 Flavoprotein; Region: Flavoprotein; pfam02441 1045855008782 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1045855008783 hypothetical protein; Reviewed; Region: PRK00024 1045855008784 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1045855008785 MPN+ (JAMM) motif; other site 1045855008786 Zinc-binding site [ion binding]; other site 1045855008787 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1045855008788 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1045855008789 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1045855008790 active site 1045855008791 HIGH motif; other site 1045855008792 KMSK motif region; other site 1045855008793 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1045855008794 tRNA binding surface [nucleotide binding]; other site 1045855008795 anticodon binding site; other site 1045855008796 Sporulation related domain; Region: SPOR; pfam05036 1045855008797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855008798 malonic semialdehyde reductase; Provisional; Region: PRK10538 1045855008799 NAD(P) binding site [chemical binding]; other site 1045855008800 active site 1045855008801 Family description; Region: UvrD_C_2; pfam13538 1045855008802 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045855008803 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1045855008804 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1045855008805 putative active site [active] 1045855008806 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1045855008807 arginine decarboxylase; Provisional; Region: PRK05354 1045855008808 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1045855008809 dimer interface [polypeptide binding]; other site 1045855008810 active site 1045855008811 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045855008812 catalytic residues [active] 1045855008813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1045855008814 spermidine synthase; Provisional; Region: PRK00811 1045855008815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045855008816 S-adenosylmethionine binding site [chemical binding]; other site 1045855008817 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1045855008818 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1045855008819 putative active site [active] 1045855008820 catalytic site [active] 1045855008821 putative metal binding site [ion binding]; other site 1045855008822 Membrane fusogenic activity; Region: BMFP; pfam04380 1045855008823 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1045855008824 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1045855008825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045855008826 Walker A motif; other site 1045855008827 ATP binding site [chemical binding]; other site 1045855008828 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1045855008829 isocitrate lyase; Provisional; Region: PRK15063 1045855008830 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1045855008831 tetramer interface [polypeptide binding]; other site 1045855008832 active site 1045855008833 Mg2+/Mn2+ binding site [ion binding]; other site 1045855008834 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1045855008835 malate synthase A; Region: malate_syn_A; TIGR01344 1045855008836 active site 1045855008837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045855008838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855008839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1045855008840 dimerization interface [polypeptide binding]; other site 1045855008841 Predicted GTPases [General function prediction only]; Region: COG1162 1045855008842 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1045855008843 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1045855008844 GTP/Mg2+ binding site [chemical binding]; other site 1045855008845 G4 box; other site 1045855008846 G5 box; other site 1045855008847 G1 box; other site 1045855008848 Switch I region; other site 1045855008849 G2 box; other site 1045855008850 G3 box; other site 1045855008851 Switch II region; other site 1045855008852 aminotransferase AlaT; Validated; Region: PRK09265 1045855008853 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045855008854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045855008855 homodimer interface [polypeptide binding]; other site 1045855008856 catalytic residue [active] 1045855008857 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1045855008858 active site 1045855008859 catalytic triad [active] 1045855008860 oxyanion hole [active] 1045855008861 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1045855008862 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1045855008863 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1045855008864 NodB motif; other site 1045855008865 active site 1045855008866 catalytic site [active] 1045855008867 metal binding site [ion binding]; metal-binding site 1045855008868 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1045855008869 putative GSH binding site [chemical binding]; other site 1045855008870 catalytic residues [active] 1045855008871 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1045855008872 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1045855008873 active site residue [active] 1045855008874 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1045855008875 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1045855008876 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1045855008877 S-formylglutathione hydrolase; Region: PLN02442 1045855008878 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1045855008879 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1045855008880 substrate binding site [chemical binding]; other site 1045855008881 catalytic Zn binding site [ion binding]; other site 1045855008882 NAD binding site [chemical binding]; other site 1045855008883 structural Zn binding site [ion binding]; other site 1045855008884 dimer interface [polypeptide binding]; other site 1045855008885 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1045855008886 putative metal binding site [ion binding]; other site 1045855008887 putative homodimer interface [polypeptide binding]; other site 1045855008888 putative homotetramer interface [polypeptide binding]; other site 1045855008889 putative homodimer-homodimer interface [polypeptide binding]; other site 1045855008890 putative allosteric switch controlling residues; other site 1045855008891 glutamate--cysteine ligase; Region: PLN02611 1045855008892 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1045855008893 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1045855008894 G1 box; other site 1045855008895 GTP/Mg2+ binding site [chemical binding]; other site 1045855008896 Switch I region; other site 1045855008897 G2 box; other site 1045855008898 G3 box; other site 1045855008899 Switch II region; other site 1045855008900 G4 box; other site 1045855008901 G5 box; other site 1045855008902 Cytochrome c; Region: Cytochrom_C; cl11414 1045855008903 Cytochrome c; Region: Cytochrom_C; cl11414 1045855008904 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1045855008905 catalytic residues [active] 1045855008906 hinge region; other site 1045855008907 alpha helical domain; other site 1045855008908 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1045855008909 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1045855008910 catalytic residues [active] 1045855008911 hinge region; other site 1045855008912 alpha helical domain; other site 1045855008913 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1045855008914 putative catalytic site [active] 1045855008915 putative metal binding site [ion binding]; other site 1045855008916 putative phosphate binding site [ion binding]; other site 1045855008917 putative catalytic site [active] 1045855008918 putative phosphate binding site [ion binding]; other site 1045855008919 putative metal binding site [ion binding]; other site 1045855008920 lytic murein transglycosylase; Provisional; Region: PRK11619 1045855008921 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045855008922 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045855008923 catalytic residue [active] 1045855008924 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1045855008925 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1045855008926 active site 1045855008927 NTP binding site [chemical binding]; other site 1045855008928 metal binding triad [ion binding]; metal-binding site 1045855008929 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1045855008930 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1045855008931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045855008932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1045855008933 dimerization interface [polypeptide binding]; other site 1045855008934 Predicted membrane protein [Function unknown]; Region: COG2855 1045855008935 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1045855008936 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1045855008937 active site 1045855008938 dimer interface [polypeptide binding]; other site 1045855008939 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1045855008940 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1045855008941 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1045855008942 active site 1045855008943 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1045855008944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1045855008945 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1045855008946 pteridine reductase; Provisional; Region: PRK09135 1045855008947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855008948 NAD(P) binding site [chemical binding]; other site 1045855008949 active site 1045855008950 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1045855008951 catalytic center binding site [active] 1045855008952 ATP binding site [chemical binding]; other site 1045855008953 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1045855008954 active site 1045855008955 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045855008956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855008957 active site 1045855008958 phosphorylation site [posttranslational modification] 1045855008959 intermolecular recognition site; other site 1045855008960 dimerization interface [polypeptide binding]; other site 1045855008961 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045855008962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855008963 active site 1045855008964 phosphorylation site [posttranslational modification] 1045855008965 intermolecular recognition site; other site 1045855008966 dimerization interface [polypeptide binding]; other site 1045855008967 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1045855008968 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1045855008969 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1045855008970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045855008971 Walker A/P-loop; other site 1045855008972 ATP binding site [chemical binding]; other site 1045855008973 Q-loop/lid; other site 1045855008974 ABC transporter signature motif; other site 1045855008975 Walker B; other site 1045855008976 D-loop; other site 1045855008977 H-loop/switch region; other site 1045855008978 helicase 45; Provisional; Region: PTZ00424 1045855008979 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1045855008980 ATP binding site [chemical binding]; other site 1045855008981 Mg++ binding site [ion binding]; other site 1045855008982 motif III; other site 1045855008983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855008984 nucleotide binding region [chemical binding]; other site 1045855008985 ATP-binding site [chemical binding]; other site 1045855008986 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1045855008987 catalytic residues [active] 1045855008988 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1045855008989 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1045855008990 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1045855008991 RNA binding site [nucleotide binding]; other site 1045855008992 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1045855008993 multimer interface [polypeptide binding]; other site 1045855008994 Walker A motif; other site 1045855008995 ATP binding site [chemical binding]; other site 1045855008996 Walker B motif; other site 1045855008997 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1045855008998 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1045855008999 TrkA-N domain; Region: TrkA_N; pfam02254 1045855009000 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1045855009001 dimer interface [polypeptide binding]; other site 1045855009002 putative tRNA-binding site [nucleotide binding]; other site 1045855009003 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045855009004 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045855009005 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045855009006 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045855009007 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045855009008 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045855009009 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045855009010 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045855009011 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045855009012 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045855009013 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045855009014 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045855009015 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045855009016 YcgL domain; Region: YcgL; pfam05166 1045855009017 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1045855009018 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1045855009019 dimer interface [polypeptide binding]; other site 1045855009020 active site 1045855009021 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1045855009022 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1045855009023 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1045855009024 Ligand binding site; other site 1045855009025 Putative Catalytic site; other site 1045855009026 DXD motif; other site 1045855009027 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1045855009028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045855009029 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1045855009030 NAD(P) binding site [chemical binding]; other site 1045855009031 active site 1045855009032 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1045855009033 active site 2 [active] 1045855009034 active site 1 [active] 1045855009035 Predicted exporter [General function prediction only]; Region: COG4258 1045855009036 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1045855009037 putative acyl-acceptor binding pocket; other site 1045855009038 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 1045855009039 active site 2 [active] 1045855009040 active site 1 [active] 1045855009041 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1045855009042 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1045855009043 putative acyl-acceptor binding pocket; other site 1045855009044 acyl carrier protein; Provisional; Region: PRK09184 1045855009045 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1045855009046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045855009047 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1045855009048 homotrimer interaction site [polypeptide binding]; other site 1045855009049 putative active site [active] 1045855009050 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045855009051 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1045855009052 acyl-activating enzyme (AAE) consensus motif; other site 1045855009053 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045855009054 AMP binding site [chemical binding]; other site 1045855009055 active site 1045855009056 acyl-activating enzyme (AAE) consensus motif; other site 1045855009057 CoA binding site [chemical binding]; other site 1045855009058 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1045855009059 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045855009060 acyl-activating enzyme (AAE) consensus motif; other site 1045855009061 AMP binding site [chemical binding]; other site 1045855009062 active site 1045855009063 CoA binding site [chemical binding]; other site 1045855009064 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1045855009065 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1045855009066 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045855009067 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1045855009068 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1045855009069 DNA polymerase I; Provisional; Region: PRK05755 1045855009070 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1045855009071 active site 1045855009072 metal binding site 1 [ion binding]; metal-binding site 1045855009073 putative 5' ssDNA interaction site; other site 1045855009074 metal binding site 3; metal-binding site 1045855009075 metal binding site 2 [ion binding]; metal-binding site 1045855009076 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1045855009077 putative DNA binding site [nucleotide binding]; other site 1045855009078 putative metal binding site [ion binding]; other site 1045855009079 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1045855009080 active site 1045855009081 catalytic site [active] 1045855009082 substrate binding site [chemical binding]; other site 1045855009083 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1045855009084 active site 1045855009085 DNA binding site [nucleotide binding] 1045855009086 catalytic site [active] 1045855009087 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1045855009088 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1045855009089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045855009090 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1045855009091 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1045855009092 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1045855009093 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1045855009094 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1045855009095 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1045855009096 C-terminal domain interface [polypeptide binding]; other site 1045855009097 GSH binding site (G-site) [chemical binding]; other site 1045855009098 dimer interface [polypeptide binding]; other site 1045855009099 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1045855009100 dimer interface [polypeptide binding]; other site 1045855009101 N-terminal domain interface [polypeptide binding]; other site 1045855009102 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1045855009103 EamA-like transporter family; Region: EamA; pfam00892 1045855009104 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1045855009105 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1045855009106 DsrE/DsrF-like family; Region: DrsE; pfam02635 1045855009107 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1045855009108 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1045855009109 MAPEG family; Region: MAPEG; cl09190 1045855009110 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1045855009111 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1045855009112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045855009113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045855009114 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1045855009115 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1045855009116 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1045855009117 putative active site [active] 1045855009118 metal binding site [ion binding]; metal-binding site 1045855009119 WYL domain; Region: WYL; pfam13280 1045855009120 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321 1045855009121 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 1045855009122 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1045855009123 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1045855009124 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1045855009125 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1045855009126 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1045855009127 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1045855009128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855009129 ATP binding site [chemical binding]; other site 1045855009130 putative Mg++ binding site [ion binding]; other site 1045855009131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855009132 nucleotide binding region [chemical binding]; other site 1045855009133 ATP-binding site [chemical binding]; other site 1045855009134 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1045855009135 RNase_H superfamily; Region: RNase_H_2; pfam13482 1045855009136 active site 1045855009137 substrate binding site [chemical binding]; other site 1045855009138 catalytic site [active] 1045855009139 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1045855009140 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1045855009141 Na binding site [ion binding]; other site 1045855009142 PAS fold; Region: PAS_7; pfam12860 1045855009143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1045855009144 putative active site [active] 1045855009145 heme pocket [chemical binding]; other site 1045855009146 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855009147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855009148 dimer interface [polypeptide binding]; other site 1045855009149 phosphorylation site [posttranslational modification] 1045855009150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855009151 ATP binding site [chemical binding]; other site 1045855009152 Mg2+ binding site [ion binding]; other site 1045855009153 G-X-G motif; other site 1045855009154 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045855009155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855009156 active site 1045855009157 phosphorylation site [posttranslational modification] 1045855009158 intermolecular recognition site; other site 1045855009159 dimerization interface [polypeptide binding]; other site 1045855009160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855009161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855009162 dimer interface [polypeptide binding]; other site 1045855009163 phosphorylation site [posttranslational modification] 1045855009164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855009165 ATP binding site [chemical binding]; other site 1045855009166 Mg2+ binding site [ion binding]; other site 1045855009167 G-X-G motif; other site 1045855009168 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045855009169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855009170 active site 1045855009171 phosphorylation site [posttranslational modification] 1045855009172 intermolecular recognition site; other site 1045855009173 dimerization interface [polypeptide binding]; other site 1045855009174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855009175 DNA binding site [nucleotide binding] 1045855009176 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1045855009177 active site 1045855009178 putative metal dependent hydrolase; Provisional; Region: PRK11598 1045855009179 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1045855009180 Sulfatase; Region: Sulfatase; pfam00884 1045855009181 Predicted ATPase [General function prediction only]; Region: COG1485 1045855009182 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1045855009183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855009184 putative substrate translocation pore; other site 1045855009185 Porin subfamily; Region: Porin_2; pfam02530 1045855009186 acetyl-CoA synthetase; Provisional; Region: PRK00174 1045855009187 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1045855009188 active site 1045855009189 CoA binding site [chemical binding]; other site 1045855009190 acyl-activating enzyme (AAE) consensus motif; other site 1045855009191 AMP binding site [chemical binding]; other site 1045855009192 acetate binding site [chemical binding]; other site 1045855009193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045855009194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855009195 active site 1045855009196 phosphorylation site [posttranslational modification] 1045855009197 intermolecular recognition site; other site 1045855009198 dimerization interface [polypeptide binding]; other site 1045855009199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045855009200 DNA binding residues [nucleotide binding] 1045855009201 dimerization interface [polypeptide binding]; other site 1045855009202 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1045855009203 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1045855009204 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1045855009205 CoA binding domain; Region: CoA_binding_2; pfam13380 1045855009206 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1045855009207 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1045855009208 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1045855009209 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1045855009210 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1045855009211 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1045855009212 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1045855009213 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1045855009214 dimer interface [polypeptide binding]; other site 1045855009215 putative radical transfer pathway; other site 1045855009216 diiron center [ion binding]; other site 1045855009217 tyrosyl radical; other site 1045855009218 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 1045855009219 ATP cone domain; Region: ATP-cone; pfam03477 1045855009220 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1045855009221 active site 1045855009222 dimer interface [polypeptide binding]; other site 1045855009223 catalytic residues [active] 1045855009224 effector binding site; other site 1045855009225 R2 peptide binding site; other site 1045855009226 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1045855009227 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1045855009228 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1045855009229 Ca2+ binding site [ion binding]; other site 1045855009230 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1045855009231 EF-hand domain pair; Region: EF_hand_5; pfam13499 1045855009232 Ca2+ binding site [ion binding]; other site 1045855009233 EF-hand domain pair; Region: EF_hand_5; pfam13499 1045855009234 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1045855009235 Ca2+ binding site [ion binding]; other site 1045855009236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045855009237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045855009238 active site 1045855009239 phosphorylation site [posttranslational modification] 1045855009240 intermolecular recognition site; other site 1045855009241 dimerization interface [polypeptide binding]; other site 1045855009242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045855009243 DNA binding site [nucleotide binding] 1045855009244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045855009245 HAMP domain; Region: HAMP; pfam00672 1045855009246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045855009247 dimer interface [polypeptide binding]; other site 1045855009248 phosphorylation site [posttranslational modification] 1045855009249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045855009250 ATP binding site [chemical binding]; other site 1045855009251 Mg2+ binding site [ion binding]; other site 1045855009252 G-X-G motif; other site 1045855009253 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1045855009254 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1045855009255 substrate binding pocket [chemical binding]; other site 1045855009256 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1045855009257 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1045855009258 nucleophile elbow; other site 1045855009259 Uncharacterized conserved protein [Function unknown]; Region: COG2013 1045855009260 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1045855009261 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045855009262 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1045855009263 Isochorismatase family; Region: Isochorismatase; pfam00857 1045855009264 catalytic triad [active] 1045855009265 metal binding site [ion binding]; metal-binding site 1045855009266 conserved cis-peptide bond; other site 1045855009267 Class I aldolases; Region: Aldolase_Class_I; cl17187 1045855009268 catalytic residue [active] 1045855009269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045855009270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045855009271 putative substrate translocation pore; other site 1045855009272 NAD-dependent deacetylase; Provisional; Region: PRK05333 1045855009273 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1045855009274 NAD+ binding site [chemical binding]; other site 1045855009275 substrate binding site [chemical binding]; other site 1045855009276 Zn binding site [ion binding]; other site 1045855009277 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1045855009278 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1045855009279 active site 1045855009280 FMN binding site [chemical binding]; other site 1045855009281 substrate binding site [chemical binding]; other site 1045855009282 homotetramer interface [polypeptide binding]; other site 1045855009283 catalytic residue [active] 1045855009284 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1045855009285 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1045855009286 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1045855009287 putative active site [active] 1045855009288 putative substrate binding site [chemical binding]; other site 1045855009289 putative cosubstrate binding site; other site 1045855009290 catalytic site [active] 1045855009291 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1045855009292 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1045855009293 C-terminal domain interface [polypeptide binding]; other site 1045855009294 GSH binding site (G-site) [chemical binding]; other site 1045855009295 dimer interface [polypeptide binding]; other site 1045855009296 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1045855009297 N-terminal domain interface [polypeptide binding]; other site 1045855009298 dimer interface [polypeptide binding]; other site 1045855009299 substrate binding pocket (H-site) [chemical binding]; other site 1045855009300 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045855009301 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045855009302 active site 1045855009303 catalytic tetrad [active] 1045855009304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1045855009305 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1045855009306 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1045855009307 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1045855009308 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1045855009309 putative heme binding pocket [chemical binding]; other site 1045855009310 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1045855009311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045855009312 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045855009313 DNA binding residues [nucleotide binding] 1045855009314 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1045855009315 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1045855009316 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1045855009317 putative metal binding site [ion binding]; other site 1045855009318 putative homodimer interface [polypeptide binding]; other site 1045855009319 putative homotetramer interface [polypeptide binding]; other site 1045855009320 putative homodimer-homodimer interface [polypeptide binding]; other site 1045855009321 putative allosteric switch controlling residues; other site 1045855009322 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1045855009323 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1045855009324 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1045855009325 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1045855009326 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045855009327 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045855009328 active site 1045855009329 catalytic tetrad [active] 1045855009330 Predicted methyltransferase [General function prediction only]; Region: COG4798 1045855009331 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1045855009332 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1045855009333 pseudouridine synthase; Region: TIGR00093 1045855009334 active site 1045855009335 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1045855009336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045855009337 ATP binding site [chemical binding]; other site 1045855009338 putative Mg++ binding site [ion binding]; other site 1045855009339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045855009340 nucleotide binding region [chemical binding]; other site 1045855009341 Helicase associated domain (HA2); Region: HA2; pfam04408 1045855009342 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1045855009343 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1045855009344 active site 1045855009345 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1045855009346 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1045855009347 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1045855009348 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1045855009349 inner membrane transport permease; Provisional; Region: PRK15066 1045855009350 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1045855009351 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045855009352 Walker A/P-loop; other site 1045855009353 ATP binding site [chemical binding]; other site 1045855009354 Q-loop/lid; other site 1045855009355 ABC transporter signature motif; other site 1045855009356 Walker B; other site 1045855009357 D-loop; other site 1045855009358 H-loop/switch region; other site 1045855009359 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1045855009360 TAP-like protein; Region: Abhydrolase_4; pfam08386 1045855009361 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1045855009362 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 1045855009363 Walker A/P-loop; other site 1045855009364 ATP binding site [chemical binding]; other site 1045855009365 Q-loop/lid; other site 1045855009366 ABC transporter signature motif; other site 1045855009367 Walker B; other site 1045855009368 D-loop; other site 1045855009369 H-loop/switch region; other site 1045855009370 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1045855009371 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1045855009372 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1045855009373 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1045855009374 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1045855009375 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1045855009376 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1045855009377 G1 box; other site 1045855009378 GTP/Mg2+ binding site [chemical binding]; other site 1045855009379 Switch I region; other site 1045855009380 G2 box; other site 1045855009381 Switch II region; other site 1045855009382 G3 box; other site 1045855009383 G4 box; other site 1045855009384 G5 box; other site 1045855009385 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1045855009386 membrane protein insertase; Provisional; Region: PRK01318 1045855009387 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1045855009388 Ribonuclease P; Region: Ribonuclease_P; cl00457 1045855009389 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399