-- dump date 20140620_020719 -- class Genbank::misc_feature -- table misc_feature_note -- id note 743721000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 743721000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 743721000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721000004 ATP binding site [chemical binding]; other site 743721000005 Walker B motif; other site 743721000006 arginine finger; other site 743721000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 743721000008 DnaA box-binding interface [nucleotide binding]; other site 743721000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 743721000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 743721000011 putative DNA binding surface [nucleotide binding]; other site 743721000012 dimer interface [polypeptide binding]; other site 743721000013 beta-clamp/clamp loader binding surface; other site 743721000014 beta-clamp/translesion DNA polymerase binding surface; other site 743721000015 recombination protein F; Reviewed; Region: recF; PRK00064 743721000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721000017 Walker A/P-loop; other site 743721000018 ATP binding site [chemical binding]; other site 743721000019 Q-loop/lid; other site 743721000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721000021 ABC transporter signature motif; other site 743721000022 Walker B; other site 743721000023 D-loop; other site 743721000024 H-loop/switch region; other site 743721000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 743721000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721000027 ATP binding site [chemical binding]; other site 743721000028 Mg2+ binding site [ion binding]; other site 743721000029 G-X-G motif; other site 743721000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 743721000031 anchoring element; other site 743721000032 dimer interface [polypeptide binding]; other site 743721000033 ATP binding site [chemical binding]; other site 743721000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 743721000035 active site 743721000036 putative metal-binding site [ion binding]; other site 743721000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 743721000038 CAAX protease self-immunity; Region: Abi; pfam02517 743721000039 Peptidase family M48; Region: Peptidase_M48; pfam01435 743721000040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721000041 binding surface 743721000042 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743721000043 TPR motif; other site 743721000044 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 743721000045 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743721000046 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 743721000047 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743721000048 TolR protein; Region: tolR; TIGR02801 743721000049 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743721000050 TolR protein; Region: tolR; TIGR02801 743721000051 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 743721000052 active site 743721000053 hydrophilic channel; other site 743721000054 dimerization interface [polypeptide binding]; other site 743721000055 catalytic residues [active] 743721000056 active site lid [active] 743721000057 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 743721000058 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 743721000059 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 743721000060 putative active site [active] 743721000061 catalytic site [active] 743721000062 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 743721000063 putative active site [active] 743721000064 catalytic site [active] 743721000065 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 743721000066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721000067 FeS/SAM binding site; other site 743721000068 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 743721000069 active site 743721000070 catalytic triad [active] 743721000071 Cupin domain; Region: Cupin_2; pfam07883 743721000072 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 743721000073 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 743721000074 NADP binding site [chemical binding]; other site 743721000075 homodimer interface [polypeptide binding]; other site 743721000076 active site 743721000077 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 743721000078 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743721000079 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743721000080 DNA binding site [nucleotide binding] 743721000081 domain linker motif; other site 743721000082 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 743721000083 putative dimerization interface [polypeptide binding]; other site 743721000084 putative ligand binding site [chemical binding]; other site 743721000085 DctM-like transporters; Region: DctM; pfam06808 743721000086 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 743721000087 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 743721000088 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743721000089 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 743721000090 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 743721000091 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 743721000092 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 743721000093 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721000094 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 743721000095 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 743721000096 substrate binding pocket [chemical binding]; other site 743721000097 catalytic triad [active] 743721000098 BNR repeat-like domain; Region: BNR_2; pfam13088 743721000099 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 743721000100 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 743721000101 active site 743721000102 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 743721000103 active site 743721000104 catalytic triad [active] 743721000105 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 743721000106 Pectic acid lyase; Region: Pec_lyase; pfam09492 743721000107 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 743721000108 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 743721000109 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721000110 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721000111 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 743721000112 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721000113 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721000114 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 743721000115 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 743721000116 substrate binding site [chemical binding]; other site 743721000117 ATP binding site [chemical binding]; other site 743721000118 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743721000119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721000120 active site 743721000121 phosphorylation site [posttranslational modification] 743721000122 intermolecular recognition site; other site 743721000123 dimerization interface [polypeptide binding]; other site 743721000124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743721000125 DNA binding residues [nucleotide binding] 743721000126 dimerization interface [polypeptide binding]; other site 743721000127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721000128 ATP binding site [chemical binding]; other site 743721000129 Mg2+ binding site [ion binding]; other site 743721000130 G-X-G motif; other site 743721000131 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 743721000132 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 743721000133 putative DNA binding site [nucleotide binding]; other site 743721000134 putative homodimer interface [polypeptide binding]; other site 743721000135 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 743721000136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743721000137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721000138 homodimer interface [polypeptide binding]; other site 743721000139 catalytic residue [active] 743721000140 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721000141 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721000142 N-terminal plug; other site 743721000143 ligand-binding site [chemical binding]; other site 743721000144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 743721000145 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 743721000146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743721000147 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 743721000148 cofactor binding site; other site 743721000149 metal binding site [ion binding]; metal-binding site 743721000150 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743721000151 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 743721000152 putative DNA binding site [nucleotide binding]; other site 743721000153 putative Zn2+ binding site [ion binding]; other site 743721000154 AsnC family; Region: AsnC_trans_reg; pfam01037 743721000155 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743721000156 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 743721000157 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 743721000158 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 743721000159 active site 743721000160 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 743721000161 Rhomboid family; Region: Rhomboid; cl11446 743721000162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 743721000163 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 743721000164 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 743721000165 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 743721000166 Predicted ATPase [General function prediction only]; Region: COG1485 743721000167 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 743721000168 Class I ribonucleotide reductase; Region: RNR_I; cd01679 743721000169 active site 743721000170 dimer interface [polypeptide binding]; other site 743721000171 catalytic residues [active] 743721000172 effector binding site; other site 743721000173 R2 peptide binding site; other site 743721000174 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 743721000175 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 743721000176 dimer interface [polypeptide binding]; other site 743721000177 putative radical transfer pathway; other site 743721000178 diiron center [ion binding]; other site 743721000179 tyrosyl radical; other site 743721000180 flavodoxin; Provisional; Region: PRK09271 743721000181 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743721000182 catalytic residues [active] 743721000183 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 743721000184 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 743721000185 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743721000186 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743721000187 dimer interface [polypeptide binding]; other site 743721000188 putative CheW interface [polypeptide binding]; other site 743721000189 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 743721000190 Isochorismatase family; Region: Isochorismatase; pfam00857 743721000191 catalytic triad [active] 743721000192 metal binding site [ion binding]; metal-binding site 743721000193 conserved cis-peptide bond; other site 743721000194 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 743721000195 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 743721000196 catalytic residue [active] 743721000197 NAD-dependent deacetylase; Provisional; Region: PRK05333 743721000198 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 743721000199 NAD+ binding site [chemical binding]; other site 743721000200 substrate binding site [chemical binding]; other site 743721000201 Zn binding site [ion binding]; other site 743721000202 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 743721000203 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 743721000204 active site 743721000205 FMN binding site [chemical binding]; other site 743721000206 substrate binding site [chemical binding]; other site 743721000207 homotetramer interface [polypeptide binding]; other site 743721000208 catalytic residue [active] 743721000209 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 743721000210 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 743721000211 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 743721000212 putative substrate binding site [chemical binding]; other site 743721000213 putative active site [active] 743721000214 putative cosubstrate binding site; other site 743721000215 catalytic site [active] 743721000216 hypothetical protein; Provisional; Region: PRK10621 743721000217 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743721000218 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 743721000219 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 743721000220 metal binding site [ion binding]; metal-binding site 743721000221 putative dimer interface [polypeptide binding]; other site 743721000222 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 743721000223 generic binding surface I; other site 743721000224 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 743721000225 putative active site [active] 743721000226 putative catalytic site [active] 743721000227 putative Mg binding site IVb [ion binding]; other site 743721000228 putative phosphate binding site [ion binding]; other site 743721000229 putative DNA binding site [nucleotide binding]; other site 743721000230 putative Mg binding site IVa [ion binding]; other site 743721000231 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 743721000232 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 743721000233 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 743721000234 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 743721000235 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 743721000236 Na binding site [ion binding]; other site 743721000237 substrate binding site [chemical binding]; other site 743721000238 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743721000239 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743721000240 DNA binding site [nucleotide binding] 743721000241 domain linker motif; other site 743721000242 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 743721000243 putative dimerization interface [polypeptide binding]; other site 743721000244 putative ligand binding site [chemical binding]; other site 743721000245 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 743721000246 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 743721000247 dimer interface [polypeptide binding]; other site 743721000248 PYR/PP interface [polypeptide binding]; other site 743721000249 TPP binding site [chemical binding]; other site 743721000250 substrate binding site [chemical binding]; other site 743721000251 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 743721000252 TPP-binding site; other site 743721000253 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 743721000254 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 743721000255 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 743721000256 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 743721000257 Predicted permeases [General function prediction only]; Region: COG0679 743721000258 Ycf46; Provisional; Region: ycf46; CHL00195 743721000259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721000260 Walker A motif; other site 743721000261 ATP binding site [chemical binding]; other site 743721000262 Walker B motif; other site 743721000263 arginine finger; other site 743721000264 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743721000265 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743721000266 P-loop; other site 743721000267 Magnesium ion binding site [ion binding]; other site 743721000268 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743721000269 catalytic core [active] 743721000270 Uncharacterized conserved protein [Function unknown]; Region: COG2353 743721000271 PLD-like domain; Region: PLDc_2; pfam13091 743721000272 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 743721000273 putative active site [active] 743721000274 catalytic site [active] 743721000275 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743721000276 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743721000277 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 743721000278 putative active site [active] 743721000279 catalytic site [active] 743721000280 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 743721000281 CoenzymeA binding site [chemical binding]; other site 743721000282 subunit interaction site [polypeptide binding]; other site 743721000283 PHB binding site; other site 743721000284 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743721000285 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743721000286 putative acyl-acceptor binding pocket; other site 743721000287 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 743721000288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721000289 binding surface 743721000290 TPR motif; other site 743721000291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721000292 binding surface 743721000293 TPR motif; other site 743721000294 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 743721000295 substrate binding site [chemical binding]; other site 743721000296 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 743721000297 glutamine synthetase; Provisional; Region: glnA; PRK09469 743721000298 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 743721000299 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743721000300 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 743721000301 Nitrogen regulatory protein P-II; Region: P-II; smart00938 743721000302 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 743721000303 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 743721000304 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 743721000305 amidase catalytic site [active] 743721000306 Zn binding residues [ion binding]; other site 743721000307 substrate binding site [chemical binding]; other site 743721000308 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743721000309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 743721000310 dimer interface [polypeptide binding]; other site 743721000311 phosphorylation site [posttranslational modification] 743721000312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721000313 ATP binding site [chemical binding]; other site 743721000314 Mg2+ binding site [ion binding]; other site 743721000315 G-X-G motif; other site 743721000316 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 743721000317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721000318 active site 743721000319 phosphorylation site [posttranslational modification] 743721000320 intermolecular recognition site; other site 743721000321 dimerization interface [polypeptide binding]; other site 743721000322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721000323 Walker A motif; other site 743721000324 ATP binding site [chemical binding]; other site 743721000325 Walker B motif; other site 743721000326 arginine finger; other site 743721000327 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743721000328 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 743721000329 E-class dimer interface [polypeptide binding]; other site 743721000330 P-class dimer interface [polypeptide binding]; other site 743721000331 active site 743721000332 Cu2+ binding site [ion binding]; other site 743721000333 Zn2+ binding site [ion binding]; other site 743721000334 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 743721000335 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743721000336 dimer interface [polypeptide binding]; other site 743721000337 active site 743721000338 HemY protein N-terminus; Region: HemY_N; pfam07219 743721000339 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 743721000340 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 743721000341 active site 743721000342 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 743721000343 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 743721000344 active site residue [active] 743721000345 preprotein translocase subunit SecB; Validated; Region: PRK05751 743721000346 SecA binding site; other site 743721000347 Preprotein binding site; other site 743721000348 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 743721000349 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 743721000350 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 743721000351 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 743721000352 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743721000353 catalytic residues [active] 743721000354 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 743721000355 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 743721000356 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 743721000357 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 743721000358 DsbD alpha interface [polypeptide binding]; other site 743721000359 catalytic residues [active] 743721000360 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 743721000361 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743721000362 catalytic residues [active] 743721000363 Uncharacterized conserved protein [Function unknown]; Region: COG2353 743721000364 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 743721000365 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 743721000366 catalytic triad [active] 743721000367 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12680 743721000368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721000369 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743721000370 dimerization interface [polypeptide binding]; other site 743721000371 sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273 743721000372 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 743721000373 C factor cell-cell signaling protein; Provisional; Region: PRK09009 743721000374 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 743721000375 NADP binding site [chemical binding]; other site 743721000376 homodimer interface [polypeptide binding]; other site 743721000377 active site 743721000378 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743721000379 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 743721000380 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743721000381 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743721000382 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 743721000383 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743721000384 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 743721000385 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 743721000386 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 743721000387 dimer interface [polypeptide binding]; other site 743721000388 active site 743721000389 CoA binding pocket [chemical binding]; other site 743721000390 hypothetical protein; Provisional; Region: PRK10396 743721000391 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 743721000392 haloalkane dehalogenase; Provisional; Region: PRK00870 743721000393 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 743721000394 peptide synthase; Provisional; Region: PRK09274 743721000395 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 743721000396 acyl-activating enzyme (AAE) consensus motif; other site 743721000397 putative AMP binding site [chemical binding]; other site 743721000398 putative active site [active] 743721000399 putative CoA binding site [chemical binding]; other site 743721000400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721000401 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 743721000402 NAD(P) binding site [chemical binding]; other site 743721000403 active site 743721000404 SCP-2 sterol transfer family; Region: SCP2; pfam02036 743721000405 ABC1 family; Region: ABC1; cl17513 743721000406 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 743721000407 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743721000408 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 743721000409 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743721000410 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743721000411 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743721000412 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 743721000413 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 743721000414 active site 743721000415 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 743721000416 hypothetical protein; Provisional; Region: PRK09256 743721000417 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743721000418 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 743721000419 putative acyl-acceptor binding pocket; other site 743721000420 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 743721000421 DNA photolyase; Region: DNA_photolyase; pfam00875 743721000422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743721000423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721000424 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743721000425 dimerization interface [polypeptide binding]; other site 743721000426 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 743721000427 malate synthase A; Region: malate_syn_A; TIGR01344 743721000428 active site 743721000429 isocitrate lyase; Provisional; Region: PRK15063 743721000430 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 743721000431 tetramer interface [polypeptide binding]; other site 743721000432 active site 743721000433 Mg2+/Mn2+ binding site [ion binding]; other site 743721000434 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743721000435 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743721000436 ligand binding site [chemical binding]; other site 743721000437 flexible hinge region; other site 743721000438 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721000439 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721000440 metal binding site [ion binding]; metal-binding site 743721000441 active site 743721000442 I-site; other site 743721000443 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 743721000444 cyclase homology domain; Region: CHD; cd07302 743721000445 nucleotidyl binding site; other site 743721000446 metal binding site [ion binding]; metal-binding site 743721000447 dimer interface [polypeptide binding]; other site 743721000448 TPR repeat; Region: TPR_11; pfam13414 743721000449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721000450 binding surface 743721000451 TPR motif; other site 743721000452 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 743721000453 putative FMN binding site [chemical binding]; other site 743721000454 NADPH bind site [chemical binding]; other site 743721000455 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 743721000456 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 743721000457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721000458 Walker A motif; other site 743721000459 ATP binding site [chemical binding]; other site 743721000460 Walker B motif; other site 743721000461 arginine finger; other site 743721000462 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 743721000463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 743721000464 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 743721000465 Nitrogen regulatory protein P-II; Region: P-II; smart00938 743721000466 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 743721000467 active site 743721000468 ATP binding site [chemical binding]; other site 743721000469 spermidine synthase; Provisional; Region: PRK00811 743721000470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721000471 S-adenosylmethionine binding site [chemical binding]; other site 743721000472 arginine decarboxylase; Provisional; Region: PRK05354 743721000473 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 743721000474 dimer interface [polypeptide binding]; other site 743721000475 active site 743721000476 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743721000477 catalytic residues [active] 743721000478 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 743721000479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721000480 malonic semialdehyde reductase; Provisional; Region: PRK10538 743721000481 NAD(P) binding site [chemical binding]; other site 743721000482 active site 743721000483 Sporulation related domain; Region: SPOR; pfam05036 743721000484 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 743721000485 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 743721000486 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 743721000487 active site 743721000488 HIGH motif; other site 743721000489 KMSK motif region; other site 743721000490 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 743721000491 tRNA binding surface [nucleotide binding]; other site 743721000492 anticodon binding site; other site 743721000493 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 743721000494 hypothetical protein; Reviewed; Region: PRK00024 743721000495 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 743721000496 MPN+ (JAMM) motif; other site 743721000497 Zinc-binding site [ion binding]; other site 743721000498 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 743721000499 Flavoprotein; Region: Flavoprotein; pfam02441 743721000500 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 743721000501 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 743721000502 trimer interface [polypeptide binding]; other site 743721000503 active site 743721000504 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 743721000505 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 743721000506 active site 743721000507 substrate binding site [chemical binding]; other site 743721000508 metal binding site [ion binding]; metal-binding site 743721000509 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743721000510 active site 743721000511 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 743721000512 putative active site [active] 743721000513 putative catalytic site [active] 743721000514 putative DNA binding site [nucleotide binding]; other site 743721000515 putative phosphate binding site [ion binding]; other site 743721000516 metal binding site A [ion binding]; metal-binding site 743721000517 putative AP binding site [nucleotide binding]; other site 743721000518 putative metal binding site B [ion binding]; other site 743721000519 muropeptide transporter; Validated; Region: ampG; cl17669 743721000520 muropeptide transporter; Validated; Region: ampG; cl17669 743721000521 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 743721000522 putative ADP-ribose binding site [chemical binding]; other site 743721000523 putative active site [active] 743721000524 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 743721000525 catalytic nucleophile [active] 743721000526 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 743721000527 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 743721000528 putative peptidase; Provisional; Region: PRK11649 743721000529 Peptidase family M23; Region: Peptidase_M23; pfam01551 743721000530 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 743721000531 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 743721000532 active site 743721000533 HIGH motif; other site 743721000534 dimer interface [polypeptide binding]; other site 743721000535 KMSKS motif; other site 743721000536 CAAX protease self-immunity; Region: Abi; pfam02517 743721000537 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 743721000538 Proline dehydrogenase; Region: Pro_dh; pfam01619 743721000539 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 743721000540 Glutamate binding site [chemical binding]; other site 743721000541 NAD binding site [chemical binding]; other site 743721000542 catalytic residues [active] 743721000543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743721000544 PAS fold; Region: PAS_4; pfam08448 743721000545 putative active site [active] 743721000546 heme pocket [chemical binding]; other site 743721000547 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743721000548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743721000549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743721000550 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 743721000551 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 743721000552 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 743721000553 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 743721000554 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743721000555 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 743721000556 Subunit I/III interface [polypeptide binding]; other site 743721000557 D-pathway; other site 743721000558 Subunit I/VIIc interface [polypeptide binding]; other site 743721000559 Subunit I/IV interface [polypeptide binding]; other site 743721000560 Subunit I/II interface [polypeptide binding]; other site 743721000561 Low-spin heme (heme a) binding site [chemical binding]; other site 743721000562 Subunit I/VIIa interface [polypeptide binding]; other site 743721000563 Subunit I/VIa interface [polypeptide binding]; other site 743721000564 Dimer interface; other site 743721000565 Putative water exit pathway; other site 743721000566 Binuclear center (heme a3/CuB) [ion binding]; other site 743721000567 K-pathway; other site 743721000568 Subunit I/Vb interface [polypeptide binding]; other site 743721000569 Putative proton exit pathway; other site 743721000570 Subunit I/VIb interface; other site 743721000571 Subunit I/VIc interface [polypeptide binding]; other site 743721000572 Electron transfer pathway; other site 743721000573 Subunit I/VIIIb interface [polypeptide binding]; other site 743721000574 Subunit I/VIIb interface [polypeptide binding]; other site 743721000575 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 743721000576 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 743721000577 Subunit III/VIIa interface [polypeptide binding]; other site 743721000578 Phospholipid binding site [chemical binding]; other site 743721000579 Subunit I/III interface [polypeptide binding]; other site 743721000580 Subunit III/VIb interface [polypeptide binding]; other site 743721000581 Subunit III/VIa interface; other site 743721000582 Subunit III/Vb interface [polypeptide binding]; other site 743721000583 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 743721000584 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 743721000585 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743721000586 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 743721000587 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 743721000588 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 743721000589 UbiA prenyltransferase family; Region: UbiA; pfam01040 743721000590 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743721000591 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 743721000592 DNA primase; Validated; Region: dnaG; PRK05667 743721000593 CHC2 zinc finger; Region: zf-CHC2; pfam01807 743721000594 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 743721000595 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 743721000596 active site 743721000597 metal binding site [ion binding]; metal-binding site 743721000598 interdomain interaction site; other site 743721000599 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 743721000600 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 743721000601 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743721000602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721000603 Coenzyme A binding pocket [chemical binding]; other site 743721000604 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 743721000605 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 743721000606 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 743721000607 Yqey-like protein; Region: YqeY; pfam09424 743721000608 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 743721000609 UGMP family protein; Validated; Region: PRK09604 743721000610 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 743721000611 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 743721000612 homooctamer interface [polypeptide binding]; other site 743721000613 active site 743721000614 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743721000615 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743721000616 Uncharacterized conserved protein [Function unknown]; Region: COG2308 743721000617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 743721000618 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 743721000619 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 743721000620 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 743721000621 active site 743721000622 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 743721000623 catalytic center binding site [active] 743721000624 ATP binding site [chemical binding]; other site 743721000625 pteridine reductase; Provisional; Region: PRK09135 743721000626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721000627 NAD(P) binding site [chemical binding]; other site 743721000628 active site 743721000629 Uncharacterized conserved protein [Function unknown]; Region: COG1565 743721000630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743721000631 VanZ like family; Region: VanZ; cl01971 743721000632 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 743721000633 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 743721000634 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 743721000635 active site 743721000636 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 743721000637 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 743721000638 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 743721000639 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721000640 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721000641 ligand-binding site [chemical binding]; other site 743721000642 Glucokinase; Region: Glucokinase; cl17310 743721000643 glucokinase, proteobacterial type; Region: glk; TIGR00749 743721000644 L-fucose transporter; Provisional; Region: PRK10133; cl17665 743721000645 glucose/galactose transporter; Region: gluP; TIGR01272 743721000646 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743721000647 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743721000648 DNA binding site [nucleotide binding] 743721000649 domain linker motif; other site 743721000650 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 743721000651 putative dimerization interface [polypeptide binding]; other site 743721000652 putative ligand binding site [chemical binding]; other site 743721000653 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 743721000654 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 743721000655 dimer interface [polypeptide binding]; other site 743721000656 active site 743721000657 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 743721000658 dimer interface [polypeptide binding]; other site 743721000659 active site 743721000660 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 743721000661 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 743721000662 active site 743721000663 dimer interface [polypeptide binding]; other site 743721000664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 743721000665 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 743721000666 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743721000667 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743721000668 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 743721000669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 743721000670 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 743721000671 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 743721000672 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 743721000673 active site 743721000674 NTP binding site [chemical binding]; other site 743721000675 metal binding triad [ion binding]; metal-binding site 743721000676 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 743721000677 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 743721000678 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743721000679 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743721000680 catalytic residue [active] 743721000681 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743721000682 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 743721000683 DNA topoisomerase I; Provisional; Region: PRK08780 743721000684 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 743721000685 active site 743721000686 interdomain interaction site; other site 743721000687 putative metal-binding site [ion binding]; other site 743721000688 nucleotide binding site [chemical binding]; other site 743721000689 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 743721000690 domain I; other site 743721000691 DNA binding groove [nucleotide binding] 743721000692 phosphate binding site [ion binding]; other site 743721000693 domain II; other site 743721000694 domain III; other site 743721000695 nucleotide binding site [chemical binding]; other site 743721000696 catalytic site [active] 743721000697 domain IV; other site 743721000698 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 743721000699 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 743721000700 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 743721000701 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 743721000702 RDD family; Region: RDD; pfam06271 743721000703 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 743721000704 Pilin (bacterial filament); Region: Pilin; pfam00114 743721000705 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 743721000706 Interferon-induced transmembrane protein; Region: CD225; pfam04505 743721000707 Protein of unknown function (DUF494); Region: DUF494; cl01103 743721000708 DNA protecting protein DprA; Region: dprA; TIGR00732 743721000709 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 743721000710 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743721000711 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 743721000712 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 743721000713 active site 743721000714 catalytic residues [active] 743721000715 metal binding site [ion binding]; metal-binding site 743721000716 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 743721000717 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 743721000718 putative active site [active] 743721000719 substrate binding site [chemical binding]; other site 743721000720 putative cosubstrate binding site; other site 743721000721 catalytic site [active] 743721000722 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 743721000723 substrate binding site [chemical binding]; other site 743721000724 16S rRNA methyltransferase B; Provisional; Region: PRK10901 743721000725 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 743721000726 putative RNA binding site [nucleotide binding]; other site 743721000727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721000728 S-adenosylmethionine binding site [chemical binding]; other site 743721000729 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 743721000730 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 743721000731 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 743721000732 O-Antigen ligase; Region: Wzy_C; pfam04932 743721000733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721000734 putative substrate translocation pore; other site 743721000735 acetyl-CoA synthetase; Provisional; Region: PRK00174 743721000736 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 743721000737 active site 743721000738 CoA binding site [chemical binding]; other site 743721000739 acyl-activating enzyme (AAE) consensus motif; other site 743721000740 AMP binding site [chemical binding]; other site 743721000741 acetate binding site [chemical binding]; other site 743721000742 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743721000743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721000744 active site 743721000745 phosphorylation site [posttranslational modification] 743721000746 intermolecular recognition site; other site 743721000747 dimerization interface [polypeptide binding]; other site 743721000748 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743721000749 DNA binding residues [nucleotide binding] 743721000750 dimerization interface [polypeptide binding]; other site 743721000751 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 743721000752 Ligand binding site; other site 743721000753 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 743721000754 DXD motif; other site 743721000755 putative hydrolase; Provisional; Region: PRK11460 743721000756 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 743721000757 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 743721000758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721000759 active site 743721000760 phosphorylation site [posttranslational modification] 743721000761 intermolecular recognition site; other site 743721000762 dimerization interface [polypeptide binding]; other site 743721000763 LytTr DNA-binding domain; Region: LytTR; pfam04397 743721000764 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 743721000765 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 743721000766 domain interfaces; other site 743721000767 active site 743721000768 Predicted transcriptional regulator [Transcription]; Region: COG2378 743721000769 HTH domain; Region: HTH_11; pfam08279 743721000770 WYL domain; Region: WYL; pfam13280 743721000771 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 743721000772 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721000773 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 743721000774 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721000775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 743721000776 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 743721000777 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 743721000778 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 743721000779 Protein of unknown function, DUF484; Region: DUF484; cl17449 743721000780 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 743721000781 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 743721000782 active site 743721000783 Int/Topo IB signature motif; other site 743721000784 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 743721000785 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 743721000786 NAD binding site [chemical binding]; other site 743721000787 catalytic Zn binding site [ion binding]; other site 743721000788 structural Zn binding site [ion binding]; other site 743721000789 Nucleoside Triphosphate Pyrophosphohydrolase EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u6; cd11543 743721000790 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 743721000791 active site 743721000792 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 743721000793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721000794 Walker A motif; other site 743721000795 ATP binding site [chemical binding]; other site 743721000796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721000797 ATP binding site [chemical binding]; other site 743721000798 Walker A motif; other site 743721000799 Walker B motif; other site 743721000800 arginine finger; other site 743721000801 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 743721000802 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 743721000803 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 743721000804 putative active site [active] 743721000805 putative metal binding site [ion binding]; other site 743721000806 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 743721000807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743721000808 ATP binding site [chemical binding]; other site 743721000809 putative Mg++ binding site [ion binding]; other site 743721000810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721000811 nucleotide binding region [chemical binding]; other site 743721000812 ATP-binding site [chemical binding]; other site 743721000813 DEAD/H associated; Region: DEAD_assoc; pfam08494 743721000814 ATP-dependent DNA ligase; Validated; Region: PRK09247 743721000815 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 743721000816 active site 743721000817 DNA binding site [nucleotide binding] 743721000818 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 743721000819 DNA binding site [nucleotide binding] 743721000820 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 743721000821 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743721000822 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 743721000823 nucleoside/Zn binding site; other site 743721000824 dimer interface [polypeptide binding]; other site 743721000825 catalytic motif [active] 743721000826 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 743721000827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721000828 S-adenosylmethionine binding site [chemical binding]; other site 743721000829 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 743721000830 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 743721000831 active site 743721000832 Zn binding site [ion binding]; other site 743721000833 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 743721000834 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 743721000835 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 743721000836 substrate binding site [chemical binding]; other site 743721000837 ATP binding site [chemical binding]; other site 743721000838 rod shape-determining protein MreB; Provisional; Region: PRK13927 743721000839 MreB and similar proteins; Region: MreB_like; cd10225 743721000840 nucleotide binding site [chemical binding]; other site 743721000841 Mg binding site [ion binding]; other site 743721000842 putative protofilament interaction site [polypeptide binding]; other site 743721000843 RodZ interaction site [polypeptide binding]; other site 743721000844 rod shape-determining protein MreC; Provisional; Region: PRK13922 743721000845 rod shape-determining protein MreC; Region: MreC; pfam04085 743721000846 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 743721000847 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 743721000848 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 743721000849 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 743721000850 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 743721000851 Transglycosylase SLT domain; Region: SLT_2; pfam13406 743721000852 murein hydrolase B; Provisional; Region: PRK10760; cl17906 743721000853 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 743721000854 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 743721000855 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 743721000856 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 743721000857 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 743721000858 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 743721000859 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 743721000860 Protein of unknown function (DUF493); Region: DUF493; cl01102 743721000861 lipoate-protein ligase B; Provisional; Region: PRK14342 743721000862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 743721000863 lipoyl synthase; Provisional; Region: PRK05481 743721000864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721000865 FeS/SAM binding site; other site 743721000866 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 743721000867 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 743721000868 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 743721000869 protein binding site [polypeptide binding]; other site 743721000870 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 743721000871 Catalytic dyad [active] 743721000872 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 743721000873 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 743721000874 putative DNA binding site [nucleotide binding]; other site 743721000875 putative Zn2+ binding site [ion binding]; other site 743721000876 AsnC family; Region: AsnC_trans_reg; pfam01037 743721000877 hydroxyglutarate oxidase; Provisional; Region: PRK11728 743721000878 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 743721000879 alanine racemase; Reviewed; Region: dadX; PRK03646 743721000880 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 743721000881 active site 743721000882 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743721000883 substrate binding site [chemical binding]; other site 743721000884 catalytic residues [active] 743721000885 dimer interface [polypeptide binding]; other site 743721000886 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 743721000887 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743721000888 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 743721000889 active site 743721000890 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 743721000891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721000892 S-adenosylmethionine binding site [chemical binding]; other site 743721000893 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 743721000894 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 743721000895 active site 743721000896 uracil binding [chemical binding]; other site 743721000897 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 743721000898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721000899 motif II; other site 743721000900 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743721000901 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721000902 N-terminal plug; other site 743721000903 ligand-binding site [chemical binding]; other site 743721000904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721000905 NAD(P) binding site [chemical binding]; other site 743721000906 active site 743721000907 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 743721000908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 743721000909 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 743721000910 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 743721000911 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 743721000912 Walker A/P-loop; other site 743721000913 ATP binding site [chemical binding]; other site 743721000914 Q-loop/lid; other site 743721000915 ABC transporter signature motif; other site 743721000916 Walker B; other site 743721000917 D-loop; other site 743721000918 H-loop/switch region; other site 743721000919 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 743721000920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743721000921 dimer interface [polypeptide binding]; other site 743721000922 conserved gate region; other site 743721000923 ABC-ATPase subunit interface; other site 743721000924 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 743721000925 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 743721000926 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 743721000927 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 743721000928 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 743721000929 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743721000930 E3 interaction surface; other site 743721000931 lipoyl attachment site [posttranslational modification]; other site 743721000932 e3 binding domain; Region: E3_binding; pfam02817 743721000933 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 743721000934 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743721000935 E3 interaction surface; other site 743721000936 lipoyl attachment site [posttranslational modification]; other site 743721000937 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743721000938 E3 interaction surface; other site 743721000939 lipoyl attachment site [posttranslational modification]; other site 743721000940 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 743721000941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743721000942 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743721000943 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743721000944 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 743721000945 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 743721000946 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 743721000947 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 743721000948 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 743721000949 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 743721000950 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 743721000951 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 743721000952 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 743721000953 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 743721000954 beta subunit interaction interface [polypeptide binding]; other site 743721000955 Walker A motif; other site 743721000956 ATP binding site [chemical binding]; other site 743721000957 Walker B motif; other site 743721000958 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 743721000959 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 743721000960 core domain interface [polypeptide binding]; other site 743721000961 delta subunit interface [polypeptide binding]; other site 743721000962 epsilon subunit interface [polypeptide binding]; other site 743721000963 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 743721000964 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 743721000965 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 743721000966 alpha subunit interaction interface [polypeptide binding]; other site 743721000967 Walker A motif; other site 743721000968 ATP binding site [chemical binding]; other site 743721000969 Walker B motif; other site 743721000970 inhibitor binding site; inhibition site 743721000971 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 743721000972 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 743721000973 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 743721000974 gamma subunit interface [polypeptide binding]; other site 743721000975 epsilon subunit interface [polypeptide binding]; other site 743721000976 LBP interface [polypeptide binding]; other site 743721000977 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 743721000978 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 743721000979 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 743721000980 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 743721000981 active site 743721000982 ribulose/triose binding site [chemical binding]; other site 743721000983 phosphate binding site [ion binding]; other site 743721000984 substrate (anthranilate) binding pocket [chemical binding]; other site 743721000985 product (indole) binding pocket [chemical binding]; other site 743721000986 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 743721000987 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 743721000988 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743721000989 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 743721000990 ligand binding site [chemical binding]; other site 743721000991 flexible hinge region; other site 743721000992 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 743721000993 putative switch regulator; other site 743721000994 non-specific DNA interactions [nucleotide binding]; other site 743721000995 DNA binding site [nucleotide binding] 743721000996 sequence specific DNA binding site [nucleotide binding]; other site 743721000997 putative cAMP binding site [chemical binding]; other site 743721000998 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 743721000999 multidrug efflux system protein; Provisional; Region: PRK11431 743721001000 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 743721001001 diiron binding motif [ion binding]; other site 743721001002 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 743721001003 23S rRNA interface [nucleotide binding]; other site 743721001004 L3 interface [polypeptide binding]; other site 743721001005 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 743721001006 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 743721001007 MASE2 domain; Region: MASE2; pfam05230 743721001008 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721001009 metal binding site [ion binding]; metal-binding site 743721001010 active site 743721001011 I-site; other site 743721001012 Family description; Region: DsbD_2; pfam13386 743721001013 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 743721001014 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 743721001015 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743721001016 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743721001017 metal-binding site [ion binding] 743721001018 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743721001019 Soluble P-type ATPase [General function prediction only]; Region: COG4087 743721001020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 743721001021 FixH; Region: FixH; pfam05751 743721001022 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 743721001023 4Fe-4S binding domain; Region: Fer4_5; pfam12801 743721001024 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 743721001025 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 743721001026 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 743721001027 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 743721001028 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 743721001029 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 743721001030 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 743721001031 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 743721001032 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 743721001033 Low-spin heme binding site [chemical binding]; other site 743721001034 Putative water exit pathway; other site 743721001035 Binuclear center (active site) [active] 743721001036 Putative proton exit pathway; other site 743721001037 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 743721001038 CoA binding domain; Region: CoA_binding_2; pfam13380 743721001039 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 743721001040 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 743721001041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743721001042 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743721001043 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 743721001044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743721001045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743721001046 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 743721001047 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 743721001048 putative hydrophobic ligand binding site [chemical binding]; other site 743721001049 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 743721001050 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 743721001051 substrate binding site [chemical binding]; other site 743721001052 ligand binding site [chemical binding]; other site 743721001053 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 743721001054 substrate binding site [chemical binding]; other site 743721001055 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 743721001056 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 743721001057 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 743721001058 Cu(I) binding site [ion binding]; other site 743721001059 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 743721001060 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 743721001061 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 743721001062 Multicopper oxidase; Region: Cu-oxidase; pfam00394 743721001063 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 743721001064 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721001065 N-terminal plug; other site 743721001066 ligand-binding site [chemical binding]; other site 743721001067 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 743721001068 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 743721001069 NnrS protein; Region: NnrS; pfam05940 743721001070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721001071 S-adenosylmethionine binding site [chemical binding]; other site 743721001072 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 743721001073 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 743721001074 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 743721001075 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743721001076 ligand binding site [chemical binding]; other site 743721001077 flexible hinge region; other site 743721001078 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 743721001079 putative switch regulator; other site 743721001080 non-specific DNA interactions [nucleotide binding]; other site 743721001081 DNA binding site [nucleotide binding] 743721001082 sequence specific DNA binding site [nucleotide binding]; other site 743721001083 putative cAMP binding site [chemical binding]; other site 743721001084 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 743721001085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721001086 FeS/SAM binding site; other site 743721001087 HemN C-terminal domain; Region: HemN_C; pfam06969 743721001088 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 743721001089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721001090 active site 743721001091 phosphorylation site [posttranslational modification] 743721001092 intermolecular recognition site; other site 743721001093 dimerization interface [polypeptide binding]; other site 743721001094 ANTAR domain; Region: ANTAR; pfam03861 743721001095 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 743721001096 NMT1-like family; Region: NMT1_2; pfam13379 743721001097 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 743721001098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721001099 putative substrate translocation pore; other site 743721001100 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 743721001101 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743721001102 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 743721001103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743721001104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743721001105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743721001106 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 743721001107 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 743721001108 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743721001109 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 743721001110 [2Fe-2S] cluster binding site [ion binding]; other site 743721001111 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 743721001112 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 743721001113 molybdopterin cofactor binding site; other site 743721001114 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 743721001115 molybdopterin cofactor binding site; other site 743721001116 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 743721001117 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 743721001118 active site 743721001119 SAM binding site [chemical binding]; other site 743721001120 homodimer interface [polypeptide binding]; other site 743721001121 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 743721001122 ferredoxin-type protein; Provisional; Region: PRK10194 743721001123 NapD protein; Region: NapD; cl01163 743721001124 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 743721001125 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 743721001126 [4Fe-4S] binding site [ion binding]; other site 743721001127 molybdopterin cofactor binding site; other site 743721001128 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 743721001129 molybdopterin cofactor binding site; other site 743721001130 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 743721001131 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 743721001132 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 743721001133 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 743721001134 putative active site [active] 743721001135 Ap4A binding site [chemical binding]; other site 743721001136 nudix motif; other site 743721001137 putative metal binding site [ion binding]; other site 743721001138 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 743721001139 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 743721001140 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 743721001141 heme binding site [chemical binding]; other site 743721001142 ferroxidase pore; other site 743721001143 ferroxidase diiron center [ion binding]; other site 743721001144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721001145 dimer interface [polypeptide binding]; other site 743721001146 phosphorylation site [posttranslational modification] 743721001147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721001148 ATP binding site [chemical binding]; other site 743721001149 Mg2+ binding site [ion binding]; other site 743721001150 G-X-G motif; other site 743721001151 Response regulator receiver domain; Region: Response_reg; pfam00072 743721001152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721001153 active site 743721001154 phosphorylation site [posttranslational modification] 743721001155 intermolecular recognition site; other site 743721001156 dimerization interface [polypeptide binding]; other site 743721001157 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743721001158 putative binding surface; other site 743721001159 active site 743721001160 Response regulator receiver domain; Region: Response_reg; pfam00072 743721001161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721001162 active site 743721001163 phosphorylation site [posttranslational modification] 743721001164 intermolecular recognition site; other site 743721001165 dimerization interface [polypeptide binding]; other site 743721001166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721001167 metal binding site [ion binding]; metal-binding site 743721001168 active site 743721001169 I-site; other site 743721001170 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743721001171 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 743721001172 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 743721001173 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 743721001174 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 743721001175 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 743721001176 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 743721001177 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 743721001178 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 743721001179 putative NADH binding site [chemical binding]; other site 743721001180 putative active site [active] 743721001181 nudix motif; other site 743721001182 putative metal binding site [ion binding]; other site 743721001183 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 743721001184 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 743721001185 Carbon starvation protein CstA; Region: CstA; pfam02554 743721001186 Interferon-induced transmembrane protein; Region: CD225; pfam04505 743721001187 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743721001188 putative acyl-acceptor binding pocket; other site 743721001189 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 743721001190 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 743721001191 putative active site [active] 743721001192 metal binding site [ion binding]; metal-binding site 743721001193 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 743721001194 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 743721001195 metal binding site [ion binding]; metal-binding site 743721001196 putative dimer interface [polypeptide binding]; other site 743721001197 aspartate aminotransferase; Provisional; Region: PRK05764 743721001198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743721001199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721001200 homodimer interface [polypeptide binding]; other site 743721001201 catalytic residue [active] 743721001202 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 743721001203 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 743721001204 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 743721001205 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 743721001206 putative acetyltransferase; Provisional; Region: PRK03624 743721001207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721001208 Coenzyme A binding pocket [chemical binding]; other site 743721001209 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 743721001210 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 743721001211 purine monophosphate binding site [chemical binding]; other site 743721001212 dimer interface [polypeptide binding]; other site 743721001213 putative catalytic residues [active] 743721001214 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 743721001215 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 743721001216 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 743721001217 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 743721001218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721001219 S-adenosylmethionine binding site [chemical binding]; other site 743721001220 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 743721001221 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743721001222 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 743721001223 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 743721001224 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 743721001225 four helix bundle protein; Region: TIGR02436 743721001226 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 743721001227 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743721001228 carboxyltransferase (CT) interaction site; other site 743721001229 biotinylation site [posttranslational modification]; other site 743721001230 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 743721001231 Dehydroquinase class II; Region: DHquinase_II; pfam01220 743721001232 active site 743721001233 trimer interface [polypeptide binding]; other site 743721001234 dimer interface [polypeptide binding]; other site 743721001235 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 743721001236 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743721001237 catalytic residues [active] 743721001238 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 743721001239 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 743721001240 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 743721001241 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743721001242 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 743721001243 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 743721001244 oligomerisation interface [polypeptide binding]; other site 743721001245 mobile loop; other site 743721001246 roof hairpin; other site 743721001247 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 743721001248 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 743721001249 ring oligomerisation interface [polypeptide binding]; other site 743721001250 ATP/Mg binding site [chemical binding]; other site 743721001251 stacking interactions; other site 743721001252 hinge regions; other site 743721001253 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 743721001254 trimer interface [polypeptide binding]; other site 743721001255 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 743721001256 trimer interface [polypeptide binding]; other site 743721001257 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 743721001258 trimer interface [polypeptide binding]; other site 743721001259 Haemagglutinin; Region: HIM; pfam05662 743721001260 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 743721001261 Catalytic domain of Protein Kinases; Region: PKc; cd00180 743721001262 active site 743721001263 ATP binding site [chemical binding]; other site 743721001264 substrate binding site [chemical binding]; other site 743721001265 activation loop (A-loop); other site 743721001266 Tetratricopeptide repeat; Region: TPR_12; pfam13424 743721001267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721001268 binding surface 743721001269 TPR motif; other site 743721001270 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 743721001271 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 743721001272 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 743721001273 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 743721001274 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743721001275 metal binding triad; other site 743721001276 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 743721001277 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743721001278 metal binding triad; other site 743721001279 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 743721001280 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 743721001281 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 743721001282 putative FMN binding site [chemical binding]; other site 743721001283 Uncharacterized conserved protein [Function unknown]; Region: COG2353 743721001284 Zinc-finger domain; Region: zf-CHCC; cl01821 743721001285 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743721001286 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 743721001287 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743721001288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743721001289 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 743721001290 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743721001291 putative acyl-acceptor binding pocket; other site 743721001292 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 743721001293 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 743721001294 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743721001295 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 743721001296 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 743721001297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721001298 S-adenosylmethionine binding site [chemical binding]; other site 743721001299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743721001300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743721001301 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 743721001302 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743721001303 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721001304 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743721001305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743721001306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721001307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743721001308 dimerization interface [polypeptide binding]; other site 743721001309 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 743721001310 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 743721001311 substrate binding site [chemical binding]; other site 743721001312 ligand binding site [chemical binding]; other site 743721001313 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 743721001314 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 743721001315 substrate binding site [chemical binding]; other site 743721001316 glutamate dehydrogenase; Provisional; Region: PRK09414 743721001317 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 743721001318 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 743721001319 NAD(P) binding site [chemical binding]; other site 743721001320 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 743721001321 2-isopropylmalate synthase; Validated; Region: PRK00915 743721001322 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 743721001323 active site 743721001324 catalytic residues [active] 743721001325 metal binding site [ion binding]; metal-binding site 743721001326 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 743721001327 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 743721001328 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 743721001329 tetramer interface [polypeptide binding]; other site 743721001330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721001331 catalytic residue [active] 743721001332 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743721001333 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 743721001334 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 743721001335 PYR/PP interface [polypeptide binding]; other site 743721001336 dimer interface [polypeptide binding]; other site 743721001337 TPP binding site [chemical binding]; other site 743721001338 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 743721001339 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 743721001340 TPP-binding site [chemical binding]; other site 743721001341 dimer interface [polypeptide binding]; other site 743721001342 ketol-acid reductoisomerase; Provisional; Region: PRK05479 743721001343 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 743721001344 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 743721001345 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 743721001346 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 743721001347 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 743721001348 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 743721001349 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 743721001350 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 743721001351 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743721001352 dimer interface [polypeptide binding]; other site 743721001353 putative CheW interface [polypeptide binding]; other site 743721001354 BCCT family transporter; Region: BCCT; pfam02028 743721001355 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 743721001356 ThiC-associated domain; Region: ThiC-associated; pfam13667 743721001357 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 743721001358 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 743721001359 HDOD domain; Region: HDOD; pfam08668 743721001360 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 743721001361 dimer interface [polypeptide binding]; other site 743721001362 substrate binding site [chemical binding]; other site 743721001363 metal binding sites [ion binding]; metal-binding site 743721001364 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 743721001365 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 743721001366 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 743721001367 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 743721001368 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 743721001369 dimer interface [polypeptide binding]; other site 743721001370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721001371 catalytic residue [active] 743721001372 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 743721001373 active site 743721001374 SAM binding site [chemical binding]; other site 743721001375 homodimer interface [polypeptide binding]; other site 743721001376 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12680 743721001377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721001378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743721001379 dimerization interface [polypeptide binding]; other site 743721001380 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 743721001381 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 743721001382 Active Sites [active] 743721001383 sulfite reductase subunit beta; Provisional; Region: PRK13504 743721001384 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743721001385 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743721001386 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 743721001387 Flavodoxin; Region: Flavodoxin_1; pfam00258 743721001388 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 743721001389 FAD binding pocket [chemical binding]; other site 743721001390 FAD binding motif [chemical binding]; other site 743721001391 catalytic residues [active] 743721001392 NAD binding pocket [chemical binding]; other site 743721001393 phosphate binding motif [ion binding]; other site 743721001394 beta-alpha-beta structure motif; other site 743721001395 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 743721001396 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 743721001397 Active Sites [active] 743721001398 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 743721001399 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 743721001400 CysD dimerization site [polypeptide binding]; other site 743721001401 G1 box; other site 743721001402 putative GEF interaction site [polypeptide binding]; other site 743721001403 GTP/Mg2+ binding site [chemical binding]; other site 743721001404 Switch I region; other site 743721001405 G2 box; other site 743721001406 G3 box; other site 743721001407 Switch II region; other site 743721001408 G4 box; other site 743721001409 G5 box; other site 743721001410 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 743721001411 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 743721001412 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 743721001413 ligand-binding site [chemical binding]; other site 743721001414 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743721001415 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721001416 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743721001417 Protein export membrane protein; Region: SecD_SecF; cl14618 743721001418 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743721001419 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743721001420 Predicted membrane protein [Function unknown]; Region: COG2311 743721001421 Protein of unknown function (DUF418); Region: DUF418; pfam04235 743721001422 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 743721001423 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 743721001424 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 743721001425 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 743721001426 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 743721001427 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 743721001428 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 743721001429 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 743721001430 PA/protease or protease-like domain interface [polypeptide binding]; other site 743721001431 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 743721001432 Peptidase family M28; Region: Peptidase_M28; pfam04389 743721001433 metal binding site [ion binding]; metal-binding site 743721001434 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 743721001435 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 743721001436 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 743721001437 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743721001438 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 743721001439 iron-sulfur cluster [ion binding]; other site 743721001440 [2Fe-2S] cluster binding site [ion binding]; other site 743721001441 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 743721001442 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 743721001443 TrkA-C domain; Region: TrkA_C; pfam02080 743721001444 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 743721001445 TrkA-C domain; Region: TrkA_C; pfam02080 743721001446 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 743721001447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721001448 S-adenosylmethionine binding site [chemical binding]; other site 743721001449 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 743721001450 ThiS interaction site; other site 743721001451 putative active site [active] 743721001452 tetramer interface [polypeptide binding]; other site 743721001453 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 743721001454 thiS-thiF/thiG interaction site; other site 743721001455 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 743721001456 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 743721001457 active site 743721001458 catalytic triad [active] 743721001459 oxyanion hole [active] 743721001460 Autotransporter beta-domain; Region: Autotransporter; cl17461 743721001461 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 743721001462 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743721001463 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743721001464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721001465 active site 743721001466 phosphorylation site [posttranslational modification] 743721001467 intermolecular recognition site; other site 743721001468 dimerization interface [polypeptide binding]; other site 743721001469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743721001470 DNA binding site [nucleotide binding] 743721001471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743721001472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721001473 dimer interface [polypeptide binding]; other site 743721001474 phosphorylation site [posttranslational modification] 743721001475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721001476 ATP binding site [chemical binding]; other site 743721001477 Mg2+ binding site [ion binding]; other site 743721001478 G-X-G motif; other site 743721001479 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 743721001480 FAD binding site [chemical binding]; other site 743721001481 Protein of unknown function (DUF3228); Region: DUF3228; pfam11539 743721001482 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 743721001483 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 743721001484 homotetramer interface [polypeptide binding]; other site 743721001485 ligand binding site [chemical binding]; other site 743721001486 catalytic site [active] 743721001487 NAD binding site [chemical binding]; other site 743721001488 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 743721001489 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 743721001490 substrate binding pocket [chemical binding]; other site 743721001491 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721001492 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 743721001493 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 743721001494 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743721001495 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 743721001496 putative ADP-binding pocket [chemical binding]; other site 743721001497 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 743721001498 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 743721001499 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 743721001500 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 743721001501 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743721001502 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743721001503 putative acyl-acceptor binding pocket; other site 743721001504 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 743721001505 S-adenosylmethionine synthetase; Validated; Region: PRK05250 743721001506 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 743721001507 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 743721001508 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 743721001509 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 743721001510 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 743721001511 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 743721001512 FMN binding site [chemical binding]; other site 743721001513 active site 743721001514 catalytic residues [active] 743721001515 substrate binding site [chemical binding]; other site 743721001516 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 743721001517 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 743721001518 substrate binding site [chemical binding]; other site 743721001519 dimer interface [polypeptide binding]; other site 743721001520 ATP binding site [chemical binding]; other site 743721001521 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 743721001522 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 743721001523 Nucleoside recognition; Region: Gate; pfam07670 743721001524 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 743721001525 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743721001526 active site 743721001527 catalytic tetrad [active] 743721001528 Hemin uptake protein hemP; Region: hemP; pfam10636 743721001529 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743721001530 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743721001531 protein binding site [polypeptide binding]; other site 743721001532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743721001533 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 743721001534 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 743721001535 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 743721001536 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 743721001537 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 743721001538 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 743721001539 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 743721001540 lipoyl attachment site [posttranslational modification]; other site 743721001541 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 743721001542 Beta-lactamase; Region: Beta-lactamase; pfam00144 743721001543 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 743721001544 Peptidase family M48; Region: Peptidase_M48; cl12018 743721001545 choline dehydrogenase; Validated; Region: PRK02106 743721001546 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 743721001547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721001548 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 743721001549 CoenzymeA binding site [chemical binding]; other site 743721001550 subunit interaction site [polypeptide binding]; other site 743721001551 PHB binding site; other site 743721001552 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 743721001553 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 743721001554 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 743721001555 active site 743721001556 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 743721001557 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743721001558 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743721001559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743721001560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743721001561 proline dipeptidase; Provisional; Region: PRK13607 743721001562 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 743721001563 active site 743721001564 PilZ domain; Region: PilZ; pfam07238 743721001565 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 743721001566 HemN family oxidoreductase; Provisional; Region: PRK05660 743721001567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721001568 FeS/SAM binding site; other site 743721001569 HemN C-terminal domain; Region: HemN_C; pfam06969 743721001570 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 743721001571 active site 743721001572 dimerization interface [polypeptide binding]; other site 743721001573 ribonuclease PH; Reviewed; Region: rph; PRK00173 743721001574 Ribonuclease PH; Region: RNase_PH_bact; cd11362 743721001575 hexamer interface [polypeptide binding]; other site 743721001576 active site 743721001577 hypothetical protein; Provisional; Region: PRK11820 743721001578 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 743721001579 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 743721001580 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 743721001581 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 743721001582 catalytic site [active] 743721001583 G-X2-G-X-G-K; other site 743721001584 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 743721001585 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743721001586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721001587 NAD(P) binding site [chemical binding]; other site 743721001588 active site 743721001589 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 743721001590 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 743721001591 Probable Catalytic site; other site 743721001592 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 743721001593 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 743721001594 Ligand binding site; other site 743721001595 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 743721001596 Transglycosylase; Region: Transgly; pfam00912 743721001597 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 743721001598 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 743721001599 DEAD/DEAH box helicase; Region: DEAD; pfam00270 743721001600 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 743721001601 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 743721001602 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 743721001603 Glycoprotease family; Region: Peptidase_M22; pfam00814 743721001604 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 743721001605 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 743721001606 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 743721001607 thymidylate synthase; Reviewed; Region: thyA; PRK01827 743721001608 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 743721001609 dimerization interface [polypeptide binding]; other site 743721001610 active site 743721001611 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 743721001612 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 743721001613 folate binding site [chemical binding]; other site 743721001614 NADP+ binding site [chemical binding]; other site 743721001615 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 743721001616 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 743721001617 active site 743721001618 metal binding site [ion binding]; metal-binding site 743721001619 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 743721001620 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 743721001621 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 743721001622 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743721001623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721001624 active site 743721001625 phosphorylation site [posttranslational modification] 743721001626 intermolecular recognition site; other site 743721001627 dimerization interface [polypeptide binding]; other site 743721001628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721001629 Walker A motif; other site 743721001630 ATP binding site [chemical binding]; other site 743721001631 Walker B motif; other site 743721001632 arginine finger; other site 743721001633 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743721001634 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743721001635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721001636 dimer interface [polypeptide binding]; other site 743721001637 phosphorylation site [posttranslational modification] 743721001638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721001639 ATP binding site [chemical binding]; other site 743721001640 Mg2+ binding site [ion binding]; other site 743721001641 G-X-G motif; other site 743721001642 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 743721001643 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 743721001644 CoA-ligase; Region: Ligase_CoA; pfam00549 743721001645 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 743721001646 CoA binding domain; Region: CoA_binding; smart00881 743721001647 CoA-ligase; Region: Ligase_CoA; pfam00549 743721001648 NAD synthetase; Provisional; Region: PRK13981 743721001649 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 743721001650 multimer interface [polypeptide binding]; other site 743721001651 active site 743721001652 catalytic triad [active] 743721001653 protein interface 1 [polypeptide binding]; other site 743721001654 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 743721001655 homodimer interface [polypeptide binding]; other site 743721001656 NAD binding pocket [chemical binding]; other site 743721001657 ATP binding pocket [chemical binding]; other site 743721001658 Mg binding site [ion binding]; other site 743721001659 active-site loop [active] 743721001660 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 743721001661 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 743721001662 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743721001663 RNA binding surface [nucleotide binding]; other site 743721001664 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 743721001665 active site 743721001666 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 743721001667 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 743721001668 Protein of unknown function, DUF481; Region: DUF481; pfam04338 743721001669 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 743721001670 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 743721001671 active site 743721001672 homotetramer interface [polypeptide binding]; other site 743721001673 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 743721001674 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 743721001675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721001676 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 743721001677 active site 743721001678 motif I; other site 743721001679 motif II; other site 743721001680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 743721001681 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721001682 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721001683 N-terminal plug; other site 743721001684 ligand-binding site [chemical binding]; other site 743721001685 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 743721001686 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721001687 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721001688 N-terminal plug; other site 743721001689 ligand-binding site [chemical binding]; other site 743721001690 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 743721001691 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 743721001692 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 743721001693 GIY-YIG motif/motif A; other site 743721001694 putative active site [active] 743721001695 putative metal binding site [ion binding]; other site 743721001696 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 743721001697 Clp amino terminal domain; Region: Clp_N; pfam02861 743721001698 Clp amino terminal domain; Region: Clp_N; pfam02861 743721001699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721001700 Walker A motif; other site 743721001701 ATP binding site [chemical binding]; other site 743721001702 Walker B motif; other site 743721001703 arginine finger; other site 743721001704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721001705 Walker A motif; other site 743721001706 ATP binding site [chemical binding]; other site 743721001707 Walker B motif; other site 743721001708 arginine finger; other site 743721001709 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 743721001710 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 743721001711 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 743721001712 homodimer interface [polypeptide binding]; other site 743721001713 substrate-cofactor binding pocket; other site 743721001714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721001715 catalytic residue [active] 743721001716 putative cation:proton antiport protein; Provisional; Region: PRK10669 743721001717 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 743721001718 TrkA-N domain; Region: TrkA_N; pfam02254 743721001719 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 743721001720 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721001721 N-terminal plug; other site 743721001722 ligand-binding site [chemical binding]; other site 743721001723 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 743721001724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721001725 Walker A/P-loop; other site 743721001726 ATP binding site [chemical binding]; other site 743721001727 Q-loop/lid; other site 743721001728 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743721001729 ABC transporter signature motif; other site 743721001730 Walker B; other site 743721001731 D-loop; other site 743721001732 ABC transporter; Region: ABC_tran_2; pfam12848 743721001733 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743721001734 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743721001735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721001736 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743721001737 dimerization interface [polypeptide binding]; other site 743721001738 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 743721001739 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 743721001740 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 743721001741 phosphoglycerol transferase I; Provisional; Region: PRK12363 743721001742 Sulfatase; Region: Sulfatase; cl17466 743721001743 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 743721001744 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 743721001745 dimer interface [polypeptide binding]; other site 743721001746 anticodon binding site; other site 743721001747 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 743721001748 homodimer interface [polypeptide binding]; other site 743721001749 motif 1; other site 743721001750 active site 743721001751 motif 2; other site 743721001752 GAD domain; Region: GAD; pfam02938 743721001753 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 743721001754 active site 743721001755 motif 3; other site 743721001756 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 743721001757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721001758 Coenzyme A binding pocket [chemical binding]; other site 743721001759 Cupin; Region: Cupin_6; pfam12852 743721001760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743721001761 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743721001762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743721001763 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 743721001764 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743721001765 hypothetical protein; Validated; Region: PRK00110 743721001766 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 743721001767 active site 743721001768 putative DNA-binding cleft [nucleotide binding]; other site 743721001769 dimer interface [polypeptide binding]; other site 743721001770 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 743721001771 RuvA N terminal domain; Region: RuvA_N; pfam01330 743721001772 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 743721001773 potassium uptake protein; Region: kup; TIGR00794 743721001774 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 743721001775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721001776 Walker A motif; other site 743721001777 ATP binding site [chemical binding]; other site 743721001778 Walker B motif; other site 743721001779 arginine finger; other site 743721001780 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 743721001781 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 743721001782 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 743721001783 SurA N-terminal domain; Region: SurA_N; pfam09312 743721001784 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 743721001785 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 743721001786 organic solvent tolerance protein; Provisional; Region: PRK04423 743721001787 OstA-like protein; Region: OstA; cl00844 743721001788 Organic solvent tolerance protein; Region: OstA_C; pfam04453 743721001789 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 743721001790 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 743721001791 putative active site [active] 743721001792 Zn binding site [ion binding]; other site 743721001793 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 743721001794 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743721001795 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 743721001796 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Validated; Region: PRK08773 743721001797 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743721001798 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 743721001799 Ca2+ binding site [ion binding]; other site 743721001800 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 743721001801 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 743721001802 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 743721001803 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721001804 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721001805 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721001806 SapC; Region: SapC; pfam07277 743721001807 Cupin-like domain; Region: Cupin_8; pfam13621 743721001808 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 743721001809 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721001810 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721001811 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721001812 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 743721001813 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 743721001814 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 743721001815 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743721001816 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743721001817 ABC transporter; Region: ABC_tran_2; pfam12848 743721001818 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743721001819 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 743721001820 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 743721001821 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 743721001822 dimer interface [polypeptide binding]; other site 743721001823 active site 743721001824 glycine-pyridoxal phosphate binding site [chemical binding]; other site 743721001825 folate binding site [chemical binding]; other site 743721001826 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 743721001827 ATP cone domain; Region: ATP-cone; pfam03477 743721001828 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743721001829 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 743721001830 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 743721001831 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 743721001832 catalytic motif [active] 743721001833 Zn binding site [ion binding]; other site 743721001834 RibD C-terminal domain; Region: RibD_C; cl17279 743721001835 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 743721001836 Lumazine binding domain; Region: Lum_binding; pfam00677 743721001837 Lumazine binding domain; Region: Lum_binding; pfam00677 743721001838 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 743721001839 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 743721001840 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 743721001841 dimerization interface [polypeptide binding]; other site 743721001842 active site 743721001843 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 743721001844 homopentamer interface [polypeptide binding]; other site 743721001845 active site 743721001846 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 743721001847 thiamine monophosphate kinase; Provisional; Region: PRK05731 743721001848 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 743721001849 ATP binding site [chemical binding]; other site 743721001850 dimerization interface [polypeptide binding]; other site 743721001851 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 743721001852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743721001853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721001854 homodimer interface [polypeptide binding]; other site 743721001855 catalytic residue [active] 743721001856 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743721001857 FAD binding domain; Region: FAD_binding_4; pfam01565 743721001858 hypothetical protein; Reviewed; Region: PRK12497 743721001859 LppC putative lipoprotein; Region: LppC; pfam04348 743721001860 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 743721001861 putative ligand binding site [chemical binding]; other site 743721001862 Predicted methyltransferases [General function prediction only]; Region: COG0313 743721001863 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 743721001864 putative SAM binding site [chemical binding]; other site 743721001865 putative homodimer interface [polypeptide binding]; other site 743721001866 cell division protein MraZ; Reviewed; Region: PRK00326 743721001867 MraZ protein; Region: MraZ; pfam02381 743721001868 MraZ protein; Region: MraZ; pfam02381 743721001869 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 743721001870 MraW methylase family; Region: Methyltransf_5; cl17771 743721001871 Cell division protein FtsL; Region: FtsL; pfam04999 743721001872 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 743721001873 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 743721001874 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 743721001875 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 743721001876 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743721001877 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743721001878 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743721001879 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743721001880 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 743721001881 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743721001882 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 743721001883 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 743721001884 Mg++ binding site [ion binding]; other site 743721001885 putative catalytic motif [active] 743721001886 putative substrate binding site [chemical binding]; other site 743721001887 cell division protein FtsW; Region: ftsW; TIGR02614 743721001888 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 743721001889 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 743721001890 active site 743721001891 homodimer interface [polypeptide binding]; other site 743721001892 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 743721001893 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743721001894 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743721001895 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743721001896 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 743721001897 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 743721001898 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743721001899 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 743721001900 Cell division protein FtsQ; Region: FtsQ; pfam03799 743721001901 cell division protein FtsA; Region: ftsA; TIGR01174 743721001902 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 743721001903 nucleotide binding site [chemical binding]; other site 743721001904 Cell division protein FtsA; Region: FtsA; pfam14450 743721001905 cell division protein FtsZ; Validated; Region: PRK09330 743721001906 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 743721001907 nucleotide binding site [chemical binding]; other site 743721001908 SulA interaction site; other site 743721001909 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 743721001910 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 743721001911 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 743721001912 Peptidase family M23; Region: Peptidase_M23; pfam01551 743721001913 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 743721001914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 743721001915 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 743721001916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 743721001917 nucleotide binding region [chemical binding]; other site 743721001918 ATP-binding site [chemical binding]; other site 743721001919 SEC-C motif; Region: SEC-C; pfam02810 743721001920 hypothetical protein; Provisional; Region: PRK08999 743721001921 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 743721001922 active site 743721001923 8-oxo-dGMP binding site [chemical binding]; other site 743721001924 nudix motif; other site 743721001925 metal binding site [ion binding]; metal-binding site 743721001926 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 743721001927 thiamine phosphate binding site [chemical binding]; other site 743721001928 active site 743721001929 pyrophosphate binding site [ion binding]; other site 743721001930 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 743721001931 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 743721001932 CoA-binding site [chemical binding]; other site 743721001933 ATP-binding [chemical binding]; other site 743721001934 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 743721001935 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 743721001936 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 743721001937 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 743721001938 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743721001939 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743721001940 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 743721001941 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 743721001942 Pilin (bacterial filament); Region: Pilin; pfam00114 743721001943 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743721001944 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743721001945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721001946 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743721001947 Walker A/P-loop; other site 743721001948 ATP binding site [chemical binding]; other site 743721001949 Q-loop/lid; other site 743721001950 ABC transporter signature motif; other site 743721001951 Walker B; other site 743721001952 D-loop; other site 743721001953 H-loop/switch region; other site 743721001954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721001955 S-adenosylmethionine binding site [chemical binding]; other site 743721001956 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 743721001957 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 743721001958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743721001959 active site 743721001960 LicD family; Region: LicD; cl01378 743721001961 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 743721001962 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 743721001963 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743721001964 active site 743721001965 nucleotide binding site [chemical binding]; other site 743721001966 HIGH motif; other site 743721001967 KMSKS motif; other site 743721001968 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 743721001969 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 743721001970 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743721001971 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 743721001972 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 743721001973 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 743721001974 Ligand binding site; other site 743721001975 Putative Catalytic site; other site 743721001976 DXD motif; other site 743721001977 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 743721001978 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 743721001979 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 743721001980 Walker A motif; other site 743721001981 ATP binding site [chemical binding]; other site 743721001982 Walker B motif; other site 743721001983 Transposase IS200 like; Region: Y1_Tnp; cl00848 743721001984 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743721001985 active site 743721001986 TolQ protein; Region: tolQ; TIGR02796 743721001987 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743721001988 TolR protein; Region: tolR; TIGR02801 743721001989 TolA protein; Region: tolA_full; TIGR02794 743721001990 TonB C terminal; Region: TonB_2; pfam13103 743721001991 translocation protein TolB; Provisional; Region: tolB; PRK04922 743721001992 TolB amino-terminal domain; Region: TolB_N; pfam04052 743721001993 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743721001994 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743721001995 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743721001996 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743721001997 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743721001998 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743721001999 ligand binding site [chemical binding]; other site 743721002000 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 743721002001 Tetratricopeptide repeat; Region: TPR_6; pfam13174 743721002002 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 743721002003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721002004 FeS/SAM binding site; other site 743721002005 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 743721002006 Ligand Binding Site [chemical binding]; other site 743721002007 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 743721002008 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 743721002009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743721002010 ATP binding site [chemical binding]; other site 743721002011 putative Mg++ binding site [ion binding]; other site 743721002012 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721002013 nucleotide binding region [chemical binding]; other site 743721002014 ATP-binding site [chemical binding]; other site 743721002015 DEAD/H associated; Region: DEAD_assoc; pfam08494 743721002016 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 743721002017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743721002018 ATP binding site [chemical binding]; other site 743721002019 putative Mg++ binding site [ion binding]; other site 743721002020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721002021 nucleotide binding region [chemical binding]; other site 743721002022 ATP-binding site [chemical binding]; other site 743721002023 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 743721002024 HRDC domain; Region: HRDC; pfam00570 743721002025 DEAD-like helicases superfamily; Region: DEXDc; smart00487 743721002026 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743721002027 ATP binding site [chemical binding]; other site 743721002028 putative Mg++ binding site [ion binding]; other site 743721002029 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721002030 nucleotide binding region [chemical binding]; other site 743721002031 ATP-binding site [chemical binding]; other site 743721002032 Helicase associated domain (HA2); Region: HA2; pfam04408 743721002033 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 743721002034 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 743721002035 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 743721002036 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 743721002037 dimerization interface [polypeptide binding]; other site 743721002038 DPS ferroxidase diiron center [ion binding]; other site 743721002039 ion pore; other site 743721002040 HD domain; Region: HD_4; pfam13328 743721002041 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 743721002042 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 743721002043 synthetase active site [active] 743721002044 NTP binding site [chemical binding]; other site 743721002045 metal binding site [ion binding]; metal-binding site 743721002046 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 743721002047 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 743721002048 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 743721002049 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743721002050 Zn2+ binding site [ion binding]; other site 743721002051 Mg2+ binding site [ion binding]; other site 743721002052 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 743721002053 synthetase active site [active] 743721002054 NTP binding site [chemical binding]; other site 743721002055 metal binding site [ion binding]; metal-binding site 743721002056 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 743721002057 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 743721002058 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 743721002059 homotrimer interaction site [polypeptide binding]; other site 743721002060 putative active site [active] 743721002061 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 743721002062 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 743721002063 generic binding surface II; other site 743721002064 ssDNA binding site; other site 743721002065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743721002066 ATP binding site [chemical binding]; other site 743721002067 putative Mg++ binding site [ion binding]; other site 743721002068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721002069 nucleotide binding region [chemical binding]; other site 743721002070 ATP-binding site [chemical binding]; other site 743721002071 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649 743721002072 active site 743721002073 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 743721002074 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 743721002075 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 743721002076 dimer interface [polypeptide binding]; other site 743721002077 active site 743721002078 citrylCoA binding site [chemical binding]; other site 743721002079 NADH binding [chemical binding]; other site 743721002080 cationic pore residues; other site 743721002081 oxalacetate/citrate binding site [chemical binding]; other site 743721002082 coenzyme A binding site [chemical binding]; other site 743721002083 catalytic triad [active] 743721002084 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 743721002085 Transglycosylase; Region: Transgly; pfam00912 743721002086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 743721002087 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 743721002088 Competence protein A; Region: Competence_A; pfam11104 743721002089 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 743721002090 nucleotide binding site [chemical binding]; other site 743721002091 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 743721002092 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 743721002093 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 743721002094 Pilus assembly protein, PilP; Region: PilP; pfam04351 743721002095 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 743721002096 Secretin and TonB N terminus short domain; Region: STN; smart00965 743721002097 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 743721002098 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743721002099 MoxR-like ATPases [General function prediction only]; Region: COG0714 743721002100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721002101 Walker A motif; other site 743721002102 ATP binding site [chemical binding]; other site 743721002103 Walker B motif; other site 743721002104 arginine finger; other site 743721002105 Protein of unknown function DUF58; Region: DUF58; pfam01882 743721002106 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 743721002107 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 743721002108 metal ion-dependent adhesion site (MIDAS); other site 743721002109 von Willebrand factor type A domain; Region: VWA_2; pfam13519 743721002110 metal ion-dependent adhesion site (MIDAS); other site 743721002111 TPR repeat; Region: TPR_11; pfam13414 743721002112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721002113 binding surface 743721002114 Oxygen tolerance; Region: BatD; pfam13584 743721002115 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 743721002116 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 743721002117 transketolase; Reviewed; Region: PRK12753 743721002118 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 743721002119 TPP-binding site [chemical binding]; other site 743721002120 dimer interface [polypeptide binding]; other site 743721002121 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 743721002122 PYR/PP interface [polypeptide binding]; other site 743721002123 dimer interface [polypeptide binding]; other site 743721002124 TPP binding site [chemical binding]; other site 743721002125 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743721002126 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 743721002127 dimer interface [polypeptide binding]; other site 743721002128 ADP-ribose binding site [chemical binding]; other site 743721002129 active site 743721002130 nudix motif; other site 743721002131 metal binding site [ion binding]; metal-binding site 743721002132 BolA-like protein; Region: BolA; pfam01722 743721002133 Penicillinase repressor; Region: Pencillinase_R; pfam03965 743721002134 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 743721002135 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743721002136 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 743721002137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721002138 Walker A/P-loop; other site 743721002139 ATP binding site [chemical binding]; other site 743721002140 ABC transporter; Region: ABC_tran; pfam00005 743721002141 Q-loop/lid; other site 743721002142 ABC transporter signature motif; other site 743721002143 Walker B; other site 743721002144 D-loop; other site 743721002145 H-loop/switch region; other site 743721002146 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 743721002147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743721002148 dimer interface [polypeptide binding]; other site 743721002149 conserved gate region; other site 743721002150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743721002151 ABC-ATPase subunit interface; other site 743721002152 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 743721002153 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743721002154 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 743721002155 active site 743721002156 Zn binding site [ion binding]; other site 743721002157 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 743721002158 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 743721002159 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 743721002160 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 743721002161 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 743721002162 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 743721002163 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 743721002164 Phosphoglycerate kinase; Region: PGK; pfam00162 743721002165 substrate binding site [chemical binding]; other site 743721002166 hinge regions; other site 743721002167 ADP binding site [chemical binding]; other site 743721002168 catalytic site [active] 743721002169 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 743721002170 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 743721002171 homodimer interface [polypeptide binding]; other site 743721002172 metal binding site [ion binding]; metal-binding site 743721002173 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 743721002174 homodimer interface [polypeptide binding]; other site 743721002175 active site 743721002176 putative chemical substrate binding site [chemical binding]; other site 743721002177 metal binding site [ion binding]; metal-binding site 743721002178 hypothetical protein; Provisional; Region: PRK02237 743721002179 Protein of unknown function, DUF486; Region: DUF486; cl01236 743721002180 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 743721002181 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 743721002182 conserved cys residue [active] 743721002183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743721002184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743721002185 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 743721002186 active site residue [active] 743721002187 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743721002188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721002189 Coenzyme A binding pocket [chemical binding]; other site 743721002190 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 743721002191 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 743721002192 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 743721002193 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743721002194 Walker A/P-loop; other site 743721002195 ATP binding site [chemical binding]; other site 743721002196 Q-loop/lid; other site 743721002197 ABC transporter signature motif; other site 743721002198 Walker B; other site 743721002199 D-loop; other site 743721002200 H-loop/switch region; other site 743721002201 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 743721002202 active site 743721002203 catalytic triad [active] 743721002204 oxyanion hole [active] 743721002205 switch loop; other site 743721002206 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743721002207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721002208 active site 743721002209 phosphorylation site [posttranslational modification] 743721002210 intermolecular recognition site; other site 743721002211 dimerization interface [polypeptide binding]; other site 743721002212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743721002213 DNA binding site [nucleotide binding] 743721002214 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743721002215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721002216 dimer interface [polypeptide binding]; other site 743721002217 phosphorylation site [posttranslational modification] 743721002218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721002219 ATP binding site [chemical binding]; other site 743721002220 Mg2+ binding site [ion binding]; other site 743721002221 G-X-G motif; other site 743721002222 macrolide transporter subunit MacA; Provisional; Region: PRK11578 743721002223 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743721002224 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721002225 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743721002226 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743721002227 Walker A/P-loop; other site 743721002228 ATP binding site [chemical binding]; other site 743721002229 Q-loop/lid; other site 743721002230 ABC transporter signature motif; other site 743721002231 Walker B; other site 743721002232 D-loop; other site 743721002233 H-loop/switch region; other site 743721002234 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743721002235 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 743721002236 FtsX-like permease family; Region: FtsX; pfam02687 743721002237 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721002238 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721002239 N-terminal plug; other site 743721002240 ligand-binding site [chemical binding]; other site 743721002241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721002242 S-adenosylmethionine binding site [chemical binding]; other site 743721002243 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 743721002244 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 743721002245 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 743721002246 dimerization interface [polypeptide binding]; other site 743721002247 domain crossover interface; other site 743721002248 redox-dependent activation switch; other site 743721002249 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 743721002250 Transglycosylase; Region: Transgly; cl17702 743721002251 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 743721002252 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 743721002253 Ligand binding site; other site 743721002254 Putative Catalytic site; other site 743721002255 DXD motif; other site 743721002256 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 743721002257 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 743721002258 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 743721002259 Haemolysin-III related; Region: HlyIII; cl03831 743721002260 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 743721002261 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 743721002262 G1 box; other site 743721002263 putative GEF interaction site [polypeptide binding]; other site 743721002264 GTP/Mg2+ binding site [chemical binding]; other site 743721002265 Switch I region; other site 743721002266 G2 box; other site 743721002267 G3 box; other site 743721002268 Switch II region; other site 743721002269 G4 box; other site 743721002270 G5 box; other site 743721002271 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 743721002272 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743721002273 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 743721002274 Walker A/P-loop; other site 743721002275 ATP binding site [chemical binding]; other site 743721002276 Q-loop/lid; other site 743721002277 ABC transporter signature motif; other site 743721002278 Walker B; other site 743721002279 D-loop; other site 743721002280 H-loop/switch region; other site 743721002281 Predicted transcriptional regulators [Transcription]; Region: COG1725 743721002282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743721002283 DNA-binding site [nucleotide binding]; DNA binding site 743721002284 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 743721002285 Peptidase family M23; Region: Peptidase_M23; pfam01551 743721002286 homoserine O-acetyltransferase; Provisional; Region: PRK08775 743721002287 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 743721002288 cystathionine gamma-synthase; Provisional; Region: PRK08776 743721002289 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 743721002290 homodimer interface [polypeptide binding]; other site 743721002291 substrate-cofactor binding pocket; other site 743721002292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721002293 catalytic residue [active] 743721002294 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 743721002295 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 743721002296 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 743721002297 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 743721002298 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 743721002299 Uncharacterized conserved protein [Function unknown]; Region: COG2353 743721002300 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 743721002301 Uncharacterized conserved protein [Function unknown]; Region: COG2353 743721002302 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 743721002303 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 743721002304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721002305 dimer interface [polypeptide binding]; other site 743721002306 phosphorylation site [posttranslational modification] 743721002307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721002308 ATP binding site [chemical binding]; other site 743721002309 Mg2+ binding site [ion binding]; other site 743721002310 G-X-G motif; other site 743721002311 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743721002312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721002313 active site 743721002314 phosphorylation site [posttranslational modification] 743721002315 intermolecular recognition site; other site 743721002316 dimerization interface [polypeptide binding]; other site 743721002317 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 743721002318 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 743721002319 substrate binding site [chemical binding]; other site 743721002320 active site 743721002321 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 743721002322 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 743721002323 active site 743721002324 dimer interface [polypeptide binding]; other site 743721002325 metal binding site [ion binding]; metal-binding site 743721002326 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 743721002327 Shikimate kinase; Region: SKI; pfam01202 743721002328 ADP binding site [chemical binding]; other site 743721002329 magnesium binding site [ion binding]; other site 743721002330 putative shikimate binding site; other site 743721002331 transcriptional regulator RcsB; Provisional; Region: PRK10840 743721002332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721002333 active site 743721002334 phosphorylation site [posttranslational modification] 743721002335 intermolecular recognition site; other site 743721002336 dimerization interface [polypeptide binding]; other site 743721002337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743721002338 DNA binding residues [nucleotide binding] 743721002339 dimerization interface [polypeptide binding]; other site 743721002340 PAS fold; Region: PAS_4; pfam08448 743721002341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721002342 putative active site [active] 743721002343 heme pocket [chemical binding]; other site 743721002344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721002345 dimer interface [polypeptide binding]; other site 743721002346 phosphorylation site [posttranslational modification] 743721002347 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 743721002348 ATP binding site [chemical binding]; other site 743721002349 Mg2+ binding site [ion binding]; other site 743721002350 G-X-G motif; other site 743721002351 Response regulator receiver domain; Region: Response_reg; pfam00072 743721002352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721002353 active site 743721002354 phosphorylation site [posttranslational modification] 743721002355 intermolecular recognition site; other site 743721002356 dimerization interface [polypeptide binding]; other site 743721002357 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 743721002358 active site 743721002359 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 743721002360 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 743721002361 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 743721002362 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743721002363 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 743721002364 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 743721002365 cobalamin binding residues [chemical binding]; other site 743721002366 putative BtuC binding residues; other site 743721002367 dimer interface [polypeptide binding]; other site 743721002368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721002369 S-adenosylmethionine binding site [chemical binding]; other site 743721002370 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 743721002371 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 743721002372 Alkaline phosphatase homologues; Region: alkPPc; smart00098 743721002373 active site 743721002374 dimer interface [polypeptide binding]; other site 743721002375 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 743721002376 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 743721002377 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 743721002378 NlpC/P60 family; Region: NLPC_P60; pfam00877 743721002379 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 743721002380 NlpC/P60 family; Region: NLPC_P60; pfam00877 743721002381 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 743721002382 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743721002383 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 743721002384 RNA/DNA hybrid binding site [nucleotide binding]; other site 743721002385 active site 743721002386 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 743721002387 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 743721002388 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 743721002389 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 743721002390 active site 743721002391 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 743721002392 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 743721002393 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 743721002394 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 743721002395 trimer interface [polypeptide binding]; other site 743721002396 active site 743721002397 UDP-GlcNAc binding site [chemical binding]; other site 743721002398 lipid binding site [chemical binding]; lipid-binding site 743721002399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 743721002400 Smr domain; Region: Smr; pfam01713 743721002401 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 743721002402 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 743721002403 Methyltransferase domain; Region: Methyltransf_18; pfam12847 743721002404 Predicted membrane protein [Function unknown]; Region: COG1238 743721002405 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 743721002406 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743721002407 Peptidase family M23; Region: Peptidase_M23; pfam01551 743721002408 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 743721002409 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 743721002410 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 743721002411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721002412 S-adenosylmethionine binding site [chemical binding]; other site 743721002413 FtsH Extracellular; Region: FtsH_ext; pfam06480 743721002414 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 743721002415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721002416 Walker A motif; other site 743721002417 ATP binding site [chemical binding]; other site 743721002418 Walker B motif; other site 743721002419 arginine finger; other site 743721002420 Peptidase family M41; Region: Peptidase_M41; pfam01434 743721002421 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 743721002422 dihydropteroate synthase; Region: DHPS; TIGR01496 743721002423 substrate binding pocket [chemical binding]; other site 743721002424 dimer interface [polypeptide binding]; other site 743721002425 inhibitor binding site; inhibition site 743721002426 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 743721002427 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 743721002428 active site 743721002429 bacterial Hfq-like; Region: Hfq; cd01716 743721002430 hexamer interface [polypeptide binding]; other site 743721002431 Sm1 motif; other site 743721002432 RNA binding site [nucleotide binding]; other site 743721002433 Sm2 motif; other site 743721002434 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 743721002435 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 743721002436 HflX GTPase family; Region: HflX; cd01878 743721002437 G1 box; other site 743721002438 GTP/Mg2+ binding site [chemical binding]; other site 743721002439 Switch I region; other site 743721002440 G2 box; other site 743721002441 G3 box; other site 743721002442 Switch II region; other site 743721002443 G4 box; other site 743721002444 G5 box; other site 743721002445 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 743721002446 HflK protein; Region: hflK; TIGR01933 743721002447 HflC protein; Region: hflC; TIGR01932 743721002448 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 743721002449 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 743721002450 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 743721002451 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 743721002452 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 743721002453 nucleotide binding site [chemical binding]; other site 743721002454 substrate binding site [chemical binding]; other site 743721002455 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 743721002456 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743721002457 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 743721002458 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743721002459 catalytic residue [active] 743721002460 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743721002461 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 743721002462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743721002463 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 743721002464 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 743721002465 substrate binding pocket [chemical binding]; other site 743721002466 chain length determination region; other site 743721002467 substrate-Mg2+ binding site; other site 743721002468 catalytic residues [active] 743721002469 aspartate-rich region 1; other site 743721002470 active site lid residues [active] 743721002471 aspartate-rich region 2; other site 743721002472 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 743721002473 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 743721002474 dimer interface [polypeptide binding]; other site 743721002475 ssDNA binding site [nucleotide binding]; other site 743721002476 tetramer (dimer of dimers) interface [polypeptide binding]; other site 743721002477 Predicted membrane protein [Function unknown]; Region: COG1297 743721002478 putative oligopeptide transporter, OPT family; Region: TIGR00733 743721002479 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 743721002480 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743721002481 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721002482 Protein of unknown function (DUF819); Region: DUF819; cl02317 743721002483 Protein of unknown function (DUF466); Region: DUF466; pfam04328 743721002484 carbon starvation protein A; Provisional; Region: PRK15015 743721002485 Carbon starvation protein CstA; Region: CstA; pfam02554 743721002486 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 743721002487 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 743721002488 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 743721002489 oligomer interface [polypeptide binding]; other site 743721002490 metal binding site [ion binding]; metal-binding site 743721002491 metal binding site [ion binding]; metal-binding site 743721002492 putative Cl binding site [ion binding]; other site 743721002493 basic sphincter; other site 743721002494 hydrophobic gate; other site 743721002495 periplasmic entrance; other site 743721002496 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 743721002497 FOG: CBS domain [General function prediction only]; Region: COG0517 743721002498 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743721002499 Transporter associated domain; Region: CorC_HlyC; smart01091 743721002500 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 743721002501 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 743721002502 PhoH-like protein; Region: PhoH; pfam02562 743721002503 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 743721002504 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 743721002505 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721002506 FeS/SAM binding site; other site 743721002507 TRAM domain; Region: TRAM; pfam01938 743721002508 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 743721002509 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743721002510 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743721002511 catalytic residue [active] 743721002512 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 743721002513 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 743721002514 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 743721002515 [2Fe-2S] cluster binding site [ion binding]; other site 743721002516 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 743721002517 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 743721002518 Qi binding site; other site 743721002519 intrachain domain interface; other site 743721002520 interchain domain interface [polypeptide binding]; other site 743721002521 heme bH binding site [chemical binding]; other site 743721002522 heme bL binding site [chemical binding]; other site 743721002523 Qo binding site; other site 743721002524 interchain domain interface [polypeptide binding]; other site 743721002525 intrachain domain interface; other site 743721002526 Qi binding site; other site 743721002527 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 743721002528 Qo binding site; other site 743721002529 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 743721002530 stringent starvation protein A; Provisional; Region: sspA; PRK09481 743721002531 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 743721002532 C-terminal domain interface [polypeptide binding]; other site 743721002533 putative GSH binding site (G-site) [chemical binding]; other site 743721002534 dimer interface [polypeptide binding]; other site 743721002535 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 743721002536 N-terminal domain interface [polypeptide binding]; other site 743721002537 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 743721002538 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 743721002539 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 743721002540 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 743721002541 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 743721002542 dimerization interface [polypeptide binding]; other site 743721002543 active site 743721002544 Trm112p-like protein; Region: Trm112p; cl01066 743721002545 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 743721002546 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 743721002547 ATP-grasp domain; Region: ATP-grasp; pfam02222 743721002548 superoxide dismutase; Provisional; Region: PRK10543 743721002549 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 743721002550 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 743721002551 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 743721002552 putative GSH binding site [chemical binding]; other site 743721002553 catalytic residues [active] 743721002554 short chain dehydrogenase; Provisional; Region: PRK08703 743721002555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721002556 NAD(P) binding site [chemical binding]; other site 743721002557 active site 743721002558 MarC family integral membrane protein; Region: MarC; cl00919 743721002559 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 743721002560 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721002561 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 743721002562 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 743721002563 Histidine kinase; Region: His_kinase; pfam06580 743721002564 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 743721002565 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 743721002566 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 743721002567 Type II transport protein GspH; Region: GspH; pfam12019 743721002568 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 743721002569 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 743721002570 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 743721002571 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 743721002572 PilX N-terminal; Region: PilX_N; pfam14341 743721002573 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 743721002574 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 743721002575 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 743721002576 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 743721002577 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 743721002578 Type II transport protein GspH; Region: GspH; pfam12019 743721002579 excinuclease ABC subunit B; Provisional; Region: PRK05298 743721002580 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743721002581 ATP binding site [chemical binding]; other site 743721002582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721002583 nucleotide binding region [chemical binding]; other site 743721002584 ATP-binding site [chemical binding]; other site 743721002585 Ultra-violet resistance protein B; Region: UvrB; pfam12344 743721002586 UvrB/uvrC motif; Region: UVR; pfam02151 743721002587 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 743721002588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743721002589 non-specific DNA binding site [nucleotide binding]; other site 743721002590 salt bridge; other site 743721002591 sequence-specific DNA binding site [nucleotide binding]; other site 743721002592 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 743721002593 Bacterial transcriptional activator domain; Region: BTAD; smart01043 743721002594 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 743721002595 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 743721002596 amidase catalytic site [active] 743721002597 Zn binding residues [ion binding]; other site 743721002598 substrate binding site [chemical binding]; other site 743721002599 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 743721002600 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 743721002601 active site 743721002602 catalytic residues [active] 743721002603 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 743721002604 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 743721002605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 743721002606 dihydroxy-acid dehydratase; Validated; Region: PRK06131 743721002607 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 743721002608 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 743721002609 Sulfate transporter family; Region: Sulfate_transp; pfam00916 743721002610 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 743721002611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743721002612 putative DNA binding site [nucleotide binding]; other site 743721002613 putative Zn2+ binding site [ion binding]; other site 743721002614 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 743721002615 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743721002616 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 743721002617 Sodium Bile acid symporter family; Region: SBF; cl17470 743721002618 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 743721002619 ArsC family; Region: ArsC; pfam03960 743721002620 catalytic residues [active] 743721002621 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 743721002622 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 743721002623 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 743721002624 active site 743721002625 catalytic residues [active] 743721002626 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 743721002627 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 743721002628 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 743721002629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721002630 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743721002631 dimerization interface [polypeptide binding]; other site 743721002632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 743721002633 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743721002634 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 743721002635 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 743721002636 putative ligand binding site [chemical binding]; other site 743721002637 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 743721002638 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 743721002639 Walker A/P-loop; other site 743721002640 ATP binding site [chemical binding]; other site 743721002641 Q-loop/lid; other site 743721002642 ABC transporter signature motif; other site 743721002643 Walker B; other site 743721002644 D-loop; other site 743721002645 H-loop/switch region; other site 743721002646 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 743721002647 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 743721002648 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 743721002649 TM-ABC transporter signature motif; other site 743721002650 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 743721002651 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 743721002652 TM-ABC transporter signature motif; other site 743721002653 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 743721002654 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 743721002655 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 743721002656 active site 743721002657 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 743721002658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721002659 Mg2+ binding site [ion binding]; other site 743721002660 G-X-G motif; other site 743721002661 Calcium-activated BK potassium channel alpha subunit; Region: BK_channel_a; pfam03493 743721002662 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 743721002663 anchoring element; other site 743721002664 dimer interface [polypeptide binding]; other site 743721002665 ATP binding site [chemical binding]; other site 743721002666 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 743721002667 active site 743721002668 metal binding site [ion binding]; metal-binding site 743721002669 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 743721002670 CTP synthetase; Validated; Region: pyrG; PRK05380 743721002671 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 743721002672 Catalytic site [active] 743721002673 active site 743721002674 UTP binding site [chemical binding]; other site 743721002675 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 743721002676 active site 743721002677 putative oxyanion hole; other site 743721002678 catalytic triad [active] 743721002679 enolase; Provisional; Region: eno; PRK00077 743721002680 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 743721002681 dimer interface [polypeptide binding]; other site 743721002682 metal binding site [ion binding]; metal-binding site 743721002683 substrate binding pocket [chemical binding]; other site 743721002684 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 743721002685 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 743721002686 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 743721002687 substrate binding site; other site 743721002688 dimer interface; other site 743721002689 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 743721002690 homotrimer interaction site [polypeptide binding]; other site 743721002691 zinc binding site [ion binding]; other site 743721002692 CDP-binding sites; other site 743721002693 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 743721002694 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 743721002695 Permutation of conserved domain; other site 743721002696 active site 743721002697 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 743721002698 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 743721002699 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743721002700 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743721002701 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743721002702 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743721002703 Surface antigen; Region: Bac_surface_Ag; pfam01103 743721002704 RIP metalloprotease RseP; Region: TIGR00054 743721002705 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 743721002706 active site 743721002707 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 743721002708 protein binding site [polypeptide binding]; other site 743721002709 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 743721002710 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 743721002711 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 743721002712 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 743721002713 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 743721002714 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 743721002715 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 743721002716 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 743721002717 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 743721002718 putative FPP binding hydrophobic cleft; other site 743721002719 dimer interface [polypeptide binding]; other site 743721002720 putative IPP diphosphate binding site; other site 743721002721 ribosome recycling factor; Reviewed; Region: frr; PRK00083 743721002722 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 743721002723 hinge region; other site 743721002724 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 743721002725 putative nucleotide binding site [chemical binding]; other site 743721002726 uridine monophosphate binding site [chemical binding]; other site 743721002727 homohexameric interface [polypeptide binding]; other site 743721002728 HDOD domain; Region: HDOD; pfam08668 743721002729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 743721002730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721002731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721002732 metal binding site [ion binding]; metal-binding site 743721002733 active site 743721002734 I-site; other site 743721002735 elongation factor Ts; Provisional; Region: tsf; PRK09377 743721002736 UBA/TS-N domain; Region: UBA; pfam00627 743721002737 Elongation factor TS; Region: EF_TS; pfam00889 743721002738 Elongation factor TS; Region: EF_TS; pfam00889 743721002739 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 743721002740 rRNA interaction site [nucleotide binding]; other site 743721002741 S8 interaction site; other site 743721002742 putative laminin-1 binding site; other site 743721002743 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 743721002744 active site 743721002745 PII uridylyl-transferase; Provisional; Region: PRK04374 743721002746 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743721002747 metal binding triad; other site 743721002748 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 743721002749 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743721002750 Zn2+ binding site [ion binding]; other site 743721002751 Mg2+ binding site [ion binding]; other site 743721002752 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 743721002753 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 743721002754 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 743721002755 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 743721002756 trimer interface [polypeptide binding]; other site 743721002757 active site 743721002758 substrate binding site [chemical binding]; other site 743721002759 CoA binding site [chemical binding]; other site 743721002760 Predicted acyl esterases [General function prediction only]; Region: COG2936 743721002761 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 743721002762 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 743721002763 ArsC family; Region: ArsC; pfam03960 743721002764 putative catalytic residues [active] 743721002765 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 743721002766 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 743721002767 metal binding site [ion binding]; metal-binding site 743721002768 dimer interface [polypeptide binding]; other site 743721002769 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 743721002770 ABC1 family; Region: ABC1; cl17513 743721002771 asparagine synthetase B; Provisional; Region: asnB; PRK09431 743721002772 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 743721002773 active site 743721002774 dimer interface [polypeptide binding]; other site 743721002775 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 743721002776 Ligand Binding Site [chemical binding]; other site 743721002777 Molecular Tunnel; other site 743721002778 NAD-dependent deacetylase; Provisional; Region: PRK00481 743721002779 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 743721002780 NAD+ binding site [chemical binding]; other site 743721002781 substrate binding site [chemical binding]; other site 743721002782 Zn binding site [ion binding]; other site 743721002783 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 743721002784 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 743721002785 active site 743721002786 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 743721002787 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 743721002788 heme binding site [chemical binding]; other site 743721002789 ferroxidase pore; other site 743721002790 ferroxidase diiron center [ion binding]; other site 743721002791 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 743721002792 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 743721002793 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 743721002794 CAP-like domain; other site 743721002795 active site 743721002796 primary dimer interface [polypeptide binding]; other site 743721002797 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 743721002798 TrkA-C domain; Region: TrkA_C; pfam02080 743721002799 TrkA-C domain; Region: TrkA_C; pfam02080 743721002800 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 743721002801 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 743721002802 ribonuclease R; Region: RNase_R; TIGR02063 743721002803 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 743721002804 RNB domain; Region: RNB; pfam00773 743721002805 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 743721002806 RNA binding site [nucleotide binding]; other site 743721002807 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743721002808 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 743721002809 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 743721002810 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 743721002811 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 743721002812 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 743721002813 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721002814 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721002815 metal binding site [ion binding]; metal-binding site 743721002816 active site 743721002817 I-site; other site 743721002818 ribonuclease T; Provisional; Region: PRK05168 743721002819 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 743721002820 active site 743721002821 catalytic site [active] 743721002822 substrate binding site [chemical binding]; other site 743721002823 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 743721002824 hypothetical protein; Provisional; Region: PRK05409 743721002825 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 743721002826 PhoU domain; Region: PhoU; pfam01895 743721002827 PhoU domain; Region: PhoU; pfam01895 743721002828 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 743721002829 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 743721002830 Walker A/P-loop; other site 743721002831 ATP binding site [chemical binding]; other site 743721002832 Q-loop/lid; other site 743721002833 ABC transporter signature motif; other site 743721002834 Walker B; other site 743721002835 D-loop; other site 743721002836 H-loop/switch region; other site 743721002837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743721002838 dimer interface [polypeptide binding]; other site 743721002839 conserved gate region; other site 743721002840 putative PBP binding loops; other site 743721002841 ABC-ATPase subunit interface; other site 743721002842 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 743721002843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743721002844 dimer interface [polypeptide binding]; other site 743721002845 conserved gate region; other site 743721002846 putative PBP binding loops; other site 743721002847 ABC-ATPase subunit interface; other site 743721002848 PBP superfamily domain; Region: PBP_like_2; cl17296 743721002849 PBP superfamily domain; Region: PBP_like_2; cl17296 743721002850 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 743721002851 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 743721002852 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 743721002853 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 743721002854 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 743721002855 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 743721002856 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 743721002857 Type II transport protein GspH; Region: GspH; pfam12019 743721002858 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 743721002859 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 743721002860 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 743721002861 type II secretion system protein F; Region: GspF; TIGR02120 743721002862 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743721002863 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743721002864 type II secretion system protein E; Region: type_II_gspE; TIGR02533 743721002865 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 743721002866 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 743721002867 Walker A motif; other site 743721002868 ATP binding site [chemical binding]; other site 743721002869 Walker B motif; other site 743721002870 type II secretion system protein D; Region: type_II_gspD; TIGR02517 743721002871 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 743721002872 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 743721002873 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 743721002874 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743721002875 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 743721002876 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 743721002877 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 743721002878 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721002879 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 743721002880 tetracycline repressor protein TetR; Provisional; Region: PRK13756 743721002881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743721002882 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 743721002883 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743721002884 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743721002885 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721002886 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743721002887 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 743721002888 M28 Zn-Peptidases; Region: M28_like_4; cd08015 743721002889 Peptidase family M28; Region: Peptidase_M28; pfam04389 743721002890 metal binding site [ion binding]; metal-binding site 743721002891 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 743721002892 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743721002893 minor groove reading motif; other site 743721002894 helix-hairpin-helix signature motif; other site 743721002895 substrate binding pocket [chemical binding]; other site 743721002896 active site 743721002897 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 743721002898 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743721002899 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 743721002900 substrate binding site [chemical binding]; other site 743721002901 oxyanion hole (OAH) forming residues; other site 743721002902 trimer interface [polypeptide binding]; other site 743721002903 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 743721002904 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 743721002905 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743721002906 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 743721002907 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 743721002908 putative active site [active] 743721002909 putative CoA binding site [chemical binding]; other site 743721002910 nudix motif; other site 743721002911 metal binding site [ion binding]; metal-binding site 743721002912 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 743721002913 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 743721002914 active site residue [active] 743721002915 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 743721002916 active site residue [active] 743721002917 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 743721002918 classical (c) SDRs; Region: SDR_c; cd05233 743721002919 NAD(P) binding site [chemical binding]; other site 743721002920 active site 743721002921 transcriptional regulator; Provisional; Region: PRK10632 743721002922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721002923 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 743721002924 putative effector binding pocket; other site 743721002925 putative dimerization interface [polypeptide binding]; other site 743721002926 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743721002927 substrate binding site [chemical binding]; other site 743721002928 oxyanion hole (OAH) forming residues; other site 743721002929 trimer interface [polypeptide binding]; other site 743721002930 Protein of unknown function (DUF461); Region: DUF461; pfam04314 743721002931 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743721002932 Ligand Binding Site [chemical binding]; other site 743721002933 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743721002934 Ligand Binding Site [chemical binding]; other site 743721002935 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743721002936 active site 743721002937 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 743721002938 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 743721002939 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 743721002940 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 743721002941 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 743721002942 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 743721002943 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 743721002944 GTPase CgtA; Reviewed; Region: obgE; PRK12299 743721002945 GTP1/OBG; Region: GTP1_OBG; pfam01018 743721002946 Obg GTPase; Region: Obg; cd01898 743721002947 G1 box; other site 743721002948 GTP/Mg2+ binding site [chemical binding]; other site 743721002949 Switch I region; other site 743721002950 G2 box; other site 743721002951 G3 box; other site 743721002952 Switch II region; other site 743721002953 G4 box; other site 743721002954 G5 box; other site 743721002955 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 743721002956 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 743721002957 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 743721002958 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 743721002959 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 743721002960 active site 743721002961 Riboflavin kinase; Region: Flavokinase; pfam01687 743721002962 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 743721002963 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743721002964 active site 743721002965 HIGH motif; other site 743721002966 nucleotide binding site [chemical binding]; other site 743721002967 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 743721002968 active site 743721002969 KMSKS motif; other site 743721002970 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 743721002971 tRNA binding surface [nucleotide binding]; other site 743721002972 anticodon binding site; other site 743721002973 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 743721002974 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 743721002975 lipoprotein signal peptidase; Provisional; Region: PRK14787 743721002976 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 743721002977 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 743721002978 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 743721002979 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 743721002980 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743721002981 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 743721002982 Protein of unknown function, DUF488; Region: DUF488; pfam04343 743721002983 DNA repair protein RadA; Provisional; Region: PRK11823 743721002984 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743721002985 Walker A motif; other site 743721002986 ATP binding site [chemical binding]; other site 743721002987 Walker B motif; other site 743721002988 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 743721002989 haemagglutination activity domain; Region: Haemagg_act; smart00912 743721002990 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 743721002991 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 743721002992 Surface antigen; Region: Bac_surface_Ag; pfam01103 743721002993 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 743721002994 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 743721002995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721002996 putative substrate translocation pore; other site 743721002997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721002998 HlyD family secretion protein; Region: HlyD; pfam00529 743721002999 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743721003000 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721003001 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 743721003002 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743721003003 MarR family; Region: MarR; pfam01047 743721003004 signal recognition particle protein; Provisional; Region: PRK10867 743721003005 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 743721003006 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 743721003007 P loop; other site 743721003008 GTP binding site [chemical binding]; other site 743721003009 Signal peptide binding domain; Region: SRP_SPB; pfam02978 743721003010 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 743721003011 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 743721003012 homodimer interface [polypeptide binding]; other site 743721003013 substrate-cofactor binding pocket; other site 743721003014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721003015 catalytic residue [active] 743721003016 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 743721003017 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 743721003018 Protein export membrane protein; Region: SecD_SecF; cl14618 743721003019 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743721003020 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743721003021 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721003022 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 743721003023 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 743721003024 RimM N-terminal domain; Region: RimM; pfam01782 743721003025 PRC-barrel domain; Region: PRC; pfam05239 743721003026 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 743721003027 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 743721003028 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743721003029 RNA binding surface [nucleotide binding]; other site 743721003030 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 743721003031 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 743721003032 heme binding site [chemical binding]; other site 743721003033 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 743721003034 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 743721003035 Predicted transcriptional regulator [Transcription]; Region: COG2378 743721003036 HTH domain; Region: HTH_11; pfam08279 743721003037 WYL domain; Region: WYL; pfam13280 743721003038 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 743721003039 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743721003040 putative C-terminal domain interface [polypeptide binding]; other site 743721003041 putative GSH binding site (G-site) [chemical binding]; other site 743721003042 putative dimer interface [polypeptide binding]; other site 743721003043 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 743721003044 dimer interface [polypeptide binding]; other site 743721003045 N-terminal domain interface [polypeptide binding]; other site 743721003046 putative substrate binding pocket (H-site) [chemical binding]; other site 743721003047 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 743721003048 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 743721003049 MutS domain I; Region: MutS_I; pfam01624 743721003050 MutS domain II; Region: MutS_II; pfam05188 743721003051 MutS domain III; Region: MutS_III; pfam05192 743721003052 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 743721003053 Walker A/P-loop; other site 743721003054 ATP binding site [chemical binding]; other site 743721003055 Q-loop/lid; other site 743721003056 ABC transporter signature motif; other site 743721003057 Walker B; other site 743721003058 D-loop; other site 743721003059 H-loop/switch region; other site 743721003060 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 743721003061 heme-binding site [chemical binding]; other site 743721003062 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721003063 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721003064 metal binding site [ion binding]; metal-binding site 743721003065 active site 743721003066 I-site; other site 743721003067 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721003068 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721003069 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721003070 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 743721003071 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 743721003072 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 743721003073 ABC1 family; Region: ABC1; cl17513 743721003074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743721003075 salt bridge; other site 743721003076 non-specific DNA binding site [nucleotide binding]; other site 743721003077 sequence-specific DNA binding site [nucleotide binding]; other site 743721003078 LexA repressor; Validated; Region: PRK00215 743721003079 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 743721003080 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743721003081 Catalytic site [active] 743721003082 recombinase A; Provisional; Region: recA; PRK09354 743721003083 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 743721003084 hexamer interface [polypeptide binding]; other site 743721003085 Walker A motif; other site 743721003086 ATP binding site [chemical binding]; other site 743721003087 Walker B motif; other site 743721003088 TfoX N-terminal domain; Region: TfoX_N; pfam04993 743721003089 recombination regulator RecX; Reviewed; Region: recX; PRK00117 743721003090 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 743721003091 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 743721003092 motif 1; other site 743721003093 active site 743721003094 motif 2; other site 743721003095 motif 3; other site 743721003096 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 743721003097 carbon storage regulator; Provisional; Region: PRK01712 743721003098 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 743721003099 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 743721003100 dimer interface [polypeptide binding]; other site 743721003101 substrate binding site [chemical binding]; other site 743721003102 ATP binding site [chemical binding]; other site 743721003103 putative transporter; Provisional; Region: PRK11660 743721003104 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 743721003105 Sulfate transporter family; Region: Sulfate_transp; pfam00916 743721003106 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 743721003107 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 743721003108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 743721003109 non-specific DNA binding site [nucleotide binding]; other site 743721003110 salt bridge; other site 743721003111 sequence-specific DNA binding site [nucleotide binding]; other site 743721003112 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 743721003113 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 743721003114 putative active site [active] 743721003115 PhoH-like protein; Region: PhoH; pfam02562 743721003116 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 743721003117 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 743721003118 catalytic triad [active] 743721003119 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 743721003120 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743721003121 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 743721003122 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 743721003123 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 743721003124 dimer interface [polypeptide binding]; other site 743721003125 active site 743721003126 catalytic residue [active] 743721003127 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 743721003128 Ferredoxin [Energy production and conversion]; Region: COG1146 743721003129 4Fe-4S binding domain; Region: Fer4; cl02805 743721003130 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 743721003131 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 743721003132 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 743721003133 galactonate dehydratase; Provisional; Region: PRK14017 743721003134 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 743721003135 putative active site pocket [active] 743721003136 putative metal binding site [ion binding]; other site 743721003137 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 743721003138 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 743721003139 active site 743721003140 intersubunit interface [polypeptide binding]; other site 743721003141 catalytic residue [active] 743721003142 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 743721003143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721003144 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 743721003145 putative dimerization interface [polypeptide binding]; other site 743721003146 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 743721003147 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721003148 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721003149 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 743721003150 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721003151 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 743721003152 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721003153 BNR repeat-like domain; Region: BNR_2; pfam13088 743721003154 Domain of unknown function (DUF303); Region: DUF303; pfam03629 743721003155 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 743721003156 Domain of unknown function (DUF303); Region: DUF303; pfam03629 743721003157 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 743721003158 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 743721003159 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 743721003160 PA14 domain; Region: PA14; pfam07691 743721003161 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 743721003162 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 743721003163 putative active site [active] 743721003164 putative catalytic site [active] 743721003165 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 743721003166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721003167 putative substrate translocation pore; other site 743721003168 poly(A) polymerase; Region: pcnB; TIGR01942 743721003169 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 743721003170 active site 743721003171 NTP binding site [chemical binding]; other site 743721003172 metal binding triad [ion binding]; metal-binding site 743721003173 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 743721003174 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 743721003175 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 743721003176 catalytic center binding site [active] 743721003177 ATP binding site [chemical binding]; other site 743721003178 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 743721003179 oligomerization interface [polypeptide binding]; other site 743721003180 active site 743721003181 metal binding site [ion binding]; metal-binding site 743721003182 Pantoate-beta-alanine ligase; Region: PanC; cd00560 743721003183 pantoate--beta-alanine ligase; Region: panC; TIGR00018 743721003184 active site 743721003185 ATP-binding site [chemical binding]; other site 743721003186 pantoate-binding site; other site 743721003187 HXXH motif; other site 743721003188 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 743721003189 tetramerization interface [polypeptide binding]; other site 743721003190 active site 743721003191 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 743721003192 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 743721003193 active site 743721003194 dimer interface [polypeptide binding]; other site 743721003195 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 743721003196 dimer interface [polypeptide binding]; other site 743721003197 active site 743721003198 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 743721003199 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 743721003200 DNA binding site [nucleotide binding] 743721003201 active site 743721003202 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 743721003203 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 743721003204 DNA binding site [nucleotide binding] 743721003205 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 743721003206 MgtE intracellular N domain; Region: MgtE_N; smart00924 743721003207 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 743721003208 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 743721003209 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 743721003210 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 743721003211 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 743721003212 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 743721003213 dimerization domain swap beta strand [polypeptide binding]; other site 743721003214 regulatory protein interface [polypeptide binding]; other site 743721003215 active site 743721003216 regulatory phosphorylation site [posttranslational modification]; other site 743721003217 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 743721003218 active pocket/dimerization site; other site 743721003219 active site 743721003220 phosphorylation site [posttranslational modification] 743721003221 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 743721003222 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 743721003223 HPr kinase/phosphorylase; Provisional; Region: PRK05428 743721003224 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 743721003225 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 743721003226 Hpr binding site; other site 743721003227 active site 743721003228 homohexamer subunit interaction site [polypeptide binding]; other site 743721003229 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 743721003230 30S subunit binding site; other site 743721003231 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 743721003232 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 743721003233 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 743721003234 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 743721003235 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 743721003236 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 743721003237 Walker A/P-loop; other site 743721003238 ATP binding site [chemical binding]; other site 743721003239 Q-loop/lid; other site 743721003240 ABC transporter signature motif; other site 743721003241 Walker B; other site 743721003242 D-loop; other site 743721003243 H-loop/switch region; other site 743721003244 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 743721003245 OstA-like protein; Region: OstA; pfam03968 743721003246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 743721003247 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 743721003248 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 743721003249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721003250 active site 743721003251 motif I; other site 743721003252 motif II; other site 743721003253 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 743721003254 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 743721003255 putative active site [active] 743721003256 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 743721003257 BolA-like protein; Region: BolA; cl00386 743721003258 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 743721003259 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 743721003260 hinge; other site 743721003261 active site 743721003262 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 743721003263 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 743721003264 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 743721003265 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 743721003266 active site 743721003267 substrate binding site [chemical binding]; other site 743721003268 cosubstrate binding site; other site 743721003269 catalytic site [active] 743721003270 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 743721003271 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 743721003272 dimerization interface [polypeptide binding]; other site 743721003273 putative ATP binding site [chemical binding]; other site 743721003274 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 743721003275 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 743721003276 Domain of unknown function DUF20; Region: UPF0118; pfam01594 743721003277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 743721003278 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 743721003279 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 743721003280 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 743721003281 Substrate binding site; other site 743721003282 metal-binding site 743721003283 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 743721003284 Phosphotransferase enzyme family; Region: APH; pfam01636 743721003285 hypothetical protein; Provisional; Region: PRK08201 743721003286 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 743721003287 metal binding site [ion binding]; metal-binding site 743721003288 putative dimer interface [polypeptide binding]; other site 743721003289 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 743721003290 HutD; Region: HutD; pfam05962 743721003291 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 743721003292 Flavodoxin; Region: Flavodoxin_1; pfam00258 743721003293 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 743721003294 FAD binding pocket [chemical binding]; other site 743721003295 FAD binding motif [chemical binding]; other site 743721003296 catalytic residues [active] 743721003297 NAD binding pocket [chemical binding]; other site 743721003298 phosphate binding motif [ion binding]; other site 743721003299 beta-alpha-beta structure motif; other site 743721003300 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 743721003301 ApbE family; Region: ApbE; pfam02424 743721003302 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 743721003303 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856 743721003304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 743721003305 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 743721003306 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721003307 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721003308 N-terminal plug; other site 743721003309 ligand-binding site [chemical binding]; other site 743721003310 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 743721003311 [2Fe-2S] cluster binding site [ion binding]; other site 743721003312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743721003313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721003314 Coenzyme A binding pocket [chemical binding]; other site 743721003315 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 743721003316 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 743721003317 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743721003318 catalytic residue [active] 743721003319 FeS assembly protein SufD; Region: sufD; TIGR01981 743721003320 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 743721003321 FeS assembly ATPase SufC; Region: sufC; TIGR01978 743721003322 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 743721003323 Walker A/P-loop; other site 743721003324 ATP binding site [chemical binding]; other site 743721003325 Q-loop/lid; other site 743721003326 ABC transporter signature motif; other site 743721003327 Walker B; other site 743721003328 D-loop; other site 743721003329 H-loop/switch region; other site 743721003330 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 743721003331 putative ABC transporter; Region: ycf24; CHL00085 743721003332 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 743721003333 Transcriptional regulator; Region: Rrf2; pfam02082 743721003334 Proteins containing SET domain [General function prediction only]; Region: COG2940 743721003335 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 743721003336 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 743721003337 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 743721003338 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 743721003339 Peptidase family M23; Region: Peptidase_M23; pfam01551 743721003340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743721003341 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721003342 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 743721003343 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 743721003344 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 743721003345 active site 743721003346 catalytic site [active] 743721003347 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 743721003348 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 743721003349 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 743721003350 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 743721003351 Ca binding site [ion binding]; other site 743721003352 active site 743721003353 catalytic site [active] 743721003354 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 743721003355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721003356 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 743721003357 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 743721003358 active site 743721003359 catalytic site [active] 743721003360 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743721003361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743721003362 DNA binding site [nucleotide binding] 743721003363 domain linker motif; other site 743721003364 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 743721003365 putative dimerization interface [polypeptide binding]; other site 743721003366 putative ligand binding site [chemical binding]; other site 743721003367 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 743721003368 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 743721003369 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 743721003370 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 743721003371 active site 743721003372 dimer interface [polypeptide binding]; other site 743721003373 motif 1; other site 743721003374 motif 2; other site 743721003375 motif 3; other site 743721003376 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 743721003377 anticodon binding site; other site 743721003378 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 743721003379 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 743721003380 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 743721003381 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 743721003382 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 743721003383 23S rRNA binding site [nucleotide binding]; other site 743721003384 L21 binding site [polypeptide binding]; other site 743721003385 L13 binding site [polypeptide binding]; other site 743721003386 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 743721003387 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 743721003388 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 743721003389 dimer interface [polypeptide binding]; other site 743721003390 motif 1; other site 743721003391 active site 743721003392 motif 2; other site 743721003393 motif 3; other site 743721003394 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 743721003395 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 743721003396 putative tRNA-binding site [nucleotide binding]; other site 743721003397 B3/4 domain; Region: B3_4; pfam03483 743721003398 tRNA synthetase B5 domain; Region: B5; smart00874 743721003399 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 743721003400 dimer interface [polypeptide binding]; other site 743721003401 motif 1; other site 743721003402 motif 3; other site 743721003403 motif 2; other site 743721003404 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 743721003405 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743721003406 IHF dimer interface [polypeptide binding]; other site 743721003407 IHF - DNA interface [nucleotide binding]; other site 743721003408 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 743721003409 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 743721003410 DNA binding residues [nucleotide binding] 743721003411 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 743721003412 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 743721003413 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743721003414 active site 743721003415 DNA binding site [nucleotide binding] 743721003416 Int/Topo IB signature motif; other site 743721003417 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 743721003418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743721003419 sequence-specific DNA binding site [nucleotide binding]; other site 743721003420 salt bridge; other site 743721003421 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 743721003422 putative DNA binding helix; other site 743721003423 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 743721003424 replicative DNA helicase; Region: DnaB; TIGR00665 743721003425 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 743721003426 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 743721003427 Walker A motif; other site 743721003428 ATP binding site [chemical binding]; other site 743721003429 Walker B motif; other site 743721003430 DNA binding loops [nucleotide binding] 743721003431 Endodeoxyribonuclease RusA; Region: RusA; cl01885 743721003432 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 743721003433 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 743721003434 active site 743721003435 metal binding site [ion binding]; metal-binding site 743721003436 Phage terminase large subunit; Region: Terminase_3; cl12054 743721003437 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 743721003438 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 743721003439 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 743721003440 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 743721003441 hypothetical protein; Region: PHA00672 743721003442 Peptidase M15; Region: Peptidase_M15_3; cl01194 743721003443 TraB family; Region: TraB; pfam01963 743721003444 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 743721003445 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 743721003446 TPP-binding site; other site 743721003447 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 743721003448 PYR/PP interface [polypeptide binding]; other site 743721003449 dimer interface [polypeptide binding]; other site 743721003450 TPP binding site [chemical binding]; other site 743721003451 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743721003452 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 743721003453 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 743721003454 active site 743721003455 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 743721003456 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 743721003457 oxidative damage protection protein; Provisional; Region: PRK05408 743721003458 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 743721003459 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743721003460 minor groove reading motif; other site 743721003461 helix-hairpin-helix signature motif; other site 743721003462 substrate binding pocket [chemical binding]; other site 743721003463 active site 743721003464 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 743721003465 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 743721003466 DNA binding and oxoG recognition site [nucleotide binding] 743721003467 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 743721003468 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 743721003469 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 743721003470 GTP binding site [chemical binding]; other site 743721003471 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 743721003472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721003473 S-adenosylmethionine binding site [chemical binding]; other site 743721003474 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 743721003475 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 743721003476 active site 743721003477 (T/H)XGH motif; other site 743721003478 ferredoxin; Validated; Region: PRK07118 743721003479 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 743721003480 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 743721003481 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743721003482 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 743721003483 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 743721003484 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743721003485 active site 743721003486 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721003487 N-terminal plug; other site 743721003488 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721003489 ligand-binding site [chemical binding]; other site 743721003490 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743721003491 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 743721003492 active site 743721003493 metal binding site [ion binding]; metal-binding site 743721003494 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 743721003495 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 743721003496 dimer interface [polypeptide binding]; other site 743721003497 substrate binding site [chemical binding]; other site 743721003498 metal binding sites [ion binding]; metal-binding site 743721003499 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 743721003500 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 743721003501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743721003502 catalytic residue [active] 743721003503 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743721003504 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 743721003505 AsnC family; Region: AsnC_trans_reg; pfam01037 743721003506 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 743721003507 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 743721003508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721003509 Radical SAM superfamily; Region: Radical_SAM; pfam04055 743721003510 FeS/SAM binding site; other site 743721003511 elongation factor P; Validated; Region: PRK00529 743721003512 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 743721003513 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 743721003514 RNA binding site [nucleotide binding]; other site 743721003515 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 743721003516 RNA binding site [nucleotide binding]; other site 743721003517 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 743721003518 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 743721003519 active site 743721003520 putative substrate binding pocket [chemical binding]; other site 743721003521 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 743721003522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721003523 S-adenosylmethionine binding site [chemical binding]; other site 743721003524 phosphoglycolate phosphatase; Provisional; Region: PRK13226 743721003525 Eukaryotic phosphomannomutase; Region: PMM; cl17107 743721003526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721003527 motif II; other site 743721003528 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 743721003529 putative GTP cyclohydrolase; Provisional; Region: PRK13674 743721003530 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 743721003531 catalytic triad [active] 743721003532 putative active site [active] 743721003533 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 743721003534 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 743721003535 Autotransporter beta-domain; Region: Autotransporter; smart00869 743721003536 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 743721003537 Peptidase family M23; Region: Peptidase_M23; pfam01551 743721003538 dihydroorotase; Reviewed; Region: PRK09236 743721003539 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743721003540 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 743721003541 active site 743721003542 Haemolytic domain; Region: Haemolytic; pfam01809 743721003543 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 743721003544 H+ Antiporter protein; Region: 2A0121; TIGR00900 743721003545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721003546 putative substrate translocation pore; other site 743721003547 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 743721003548 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 743721003549 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743721003550 active site 743721003551 HIGH motif; other site 743721003552 nucleotide binding site [chemical binding]; other site 743721003553 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 743721003554 KMSKS motif; other site 743721003555 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 743721003556 tRNA binding surface [nucleotide binding]; other site 743721003557 anticodon binding site; other site 743721003558 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 743721003559 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 743721003560 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 743721003561 argininosuccinate synthase; Provisional; Region: PRK04527 743721003562 argininosuccinate synthase; Provisional; Region: PRK13820 743721003563 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743721003564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721003565 Coenzyme A binding pocket [chemical binding]; other site 743721003566 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 743721003567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721003568 Coenzyme A binding pocket [chemical binding]; other site 743721003569 acetylornithine deacetylase; Provisional; Region: PRK08737 743721003570 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 743721003571 metal binding site [ion binding]; metal-binding site 743721003572 acetylglutamate kinase; Provisional; Region: PRK04531 743721003573 AAK_NAGK-fArgBP: N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-terminal...; Region: AAK_NAGK-fArgBP; cd04252 743721003574 putative nucleotide binding site [chemical binding]; other site 743721003575 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 743721003576 DUF619 domain of various N-acetylglutamate Synthases of the fungal arginine-biosynthetic pathway and urea cycle found in humans and fish; Region: DUF619-NAGS; cd04264 743721003577 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 743721003578 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743721003579 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 743721003580 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 743721003581 argininosuccinate lyase; Provisional; Region: PRK00855 743721003582 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 743721003583 active sites [active] 743721003584 tetramer interface [polypeptide binding]; other site 743721003585 YCII-related domain; Region: YCII; cl00999 743721003586 gamma-glutamyl kinase; Provisional; Region: PRK05429 743721003587 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 743721003588 nucleotide binding site [chemical binding]; other site 743721003589 PUA domain; Region: PUA; pfam01472 743721003590 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 743721003591 putative catalytic cysteine [active] 743721003592 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 743721003593 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 743721003594 EamA-like transporter family; Region: EamA; pfam00892 743721003595 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 743721003596 FAD binding domain; Region: FAD_binding_4; pfam01565 743721003597 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 743721003598 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 743721003599 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 743721003600 quinone interaction residues [chemical binding]; other site 743721003601 active site 743721003602 catalytic residues [active] 743721003603 FMN binding site [chemical binding]; other site 743721003604 substrate binding site [chemical binding]; other site 743721003605 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 743721003606 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743721003607 active site 743721003608 metal binding site [ion binding]; metal-binding site 743721003609 aldehyde dehydrogenase family 7 member; Region: PLN02315 743721003610 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 743721003611 tetrameric interface [polypeptide binding]; other site 743721003612 NAD binding site [chemical binding]; other site 743721003613 catalytic residues [active] 743721003614 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 743721003615 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743721003616 DNA-binding site [nucleotide binding]; DNA binding site 743721003617 RNA-binding motif; other site 743721003618 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 743721003619 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 743721003620 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 743721003621 nucleotide binding site [chemical binding]; other site 743721003622 substrate binding site [chemical binding]; other site 743721003623 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 743721003624 dimer interface [polypeptide binding]; other site 743721003625 putative threonine allosteric regulatory site; other site 743721003626 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 743721003627 putative threonine allosteric regulatory site; other site 743721003628 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 743721003629 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 743721003630 homoserine kinase; Provisional; Region: PRK01212 743721003631 threonine synthase; Validated; Region: PRK09225 743721003632 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 743721003633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743721003634 catalytic residue [active] 743721003635 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 743721003636 putative active site [active] 743721003637 nucleotide binding site [chemical binding]; other site 743721003638 nudix motif; other site 743721003639 putative metal binding site [ion binding]; other site 743721003640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721003641 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 743721003642 NAD(P) binding site [chemical binding]; other site 743721003643 active site 743721003644 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 743721003645 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 743721003646 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 743721003647 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 743721003648 hypothetical protein; Provisional; Region: PRK10318 743721003649 PspC domain; Region: PspC; pfam04024 743721003650 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 743721003651 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 743721003652 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 743721003653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721003654 TPR motif; other site 743721003655 binding surface 743721003656 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 743721003657 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 743721003658 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 743721003659 catalytic residues [active] 743721003660 central insert; other site 743721003661 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 743721003662 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 743721003663 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 743721003664 CcmB protein; Region: CcmB; cl17444 743721003665 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13543 743721003666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721003667 Walker A/P-loop; other site 743721003668 ATP binding site [chemical binding]; other site 743721003669 Q-loop/lid; other site 743721003670 ABC transporter signature motif; other site 743721003671 Walker B; other site 743721003672 D-loop; other site 743721003673 H-loop/switch region; other site 743721003674 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 743721003675 methionine aminotransferase; Validated; Region: PRK09082 743721003676 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743721003677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721003678 homodimer interface [polypeptide binding]; other site 743721003679 catalytic residue [active] 743721003680 C-N hydrolase family amidase; Provisional; Region: PRK10438 743721003681 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 743721003682 putative active site [active] 743721003683 catalytic triad [active] 743721003684 dimer interface [polypeptide binding]; other site 743721003685 multimer interface [polypeptide binding]; other site 743721003686 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 743721003687 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743721003688 RNA binding surface [nucleotide binding]; other site 743721003689 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 743721003690 active site 743721003691 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 743721003692 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 743721003693 YciI-like protein; Reviewed; Region: PRK11370 743721003694 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743721003695 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743721003696 DNA binding site [nucleotide binding] 743721003697 domain linker motif; other site 743721003698 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 743721003699 dimerization interface [polypeptide binding]; other site 743721003700 ligand binding site [chemical binding]; other site 743721003701 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 743721003702 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721003703 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721003704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 743721003705 Putative glucoamylase; Region: Glycoamylase; pfam10091 743721003706 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 743721003707 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 743721003708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743721003709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743721003710 putative PBP binding loops; other site 743721003711 ABC-ATPase subunit interface; other site 743721003712 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 743721003713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743721003714 dimer interface [polypeptide binding]; other site 743721003715 conserved gate region; other site 743721003716 putative PBP binding loops; other site 743721003717 ABC-ATPase subunit interface; other site 743721003718 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 743721003719 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 743721003720 Protein of unknown function, DUF608; Region: DUF608; pfam04685 743721003721 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 743721003722 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 743721003723 active site 743721003724 intersubunit interface [polypeptide binding]; other site 743721003725 catalytic residue [active] 743721003726 phosphogluconate dehydratase; Validated; Region: PRK09054 743721003727 6-phosphogluconate dehydratase; Region: edd; TIGR01196 743721003728 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 743721003729 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 743721003730 putative active site [active] 743721003731 glucokinase, proteobacterial type; Region: glk; TIGR00749 743721003732 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 743721003733 nucleotide binding site [chemical binding]; other site 743721003734 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 743721003735 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 743721003736 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 743721003737 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 743721003738 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 743721003739 Walker A/P-loop; other site 743721003740 ATP binding site [chemical binding]; other site 743721003741 Q-loop/lid; other site 743721003742 ABC transporter signature motif; other site 743721003743 Walker B; other site 743721003744 D-loop; other site 743721003745 H-loop/switch region; other site 743721003746 TOBE domain; Region: TOBE_2; pfam08402 743721003747 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 743721003748 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 743721003749 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 743721003750 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 743721003751 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 743721003752 Iron-sulfur protein interface; other site 743721003753 proximal quinone binding site [chemical binding]; other site 743721003754 SdhD (CybS) interface [polypeptide binding]; other site 743721003755 proximal heme binding site [chemical binding]; other site 743721003756 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 743721003757 putative SdhC subunit interface [polypeptide binding]; other site 743721003758 putative proximal heme binding site [chemical binding]; other site 743721003759 putative Iron-sulfur protein interface [polypeptide binding]; other site 743721003760 putative proximal quinone binding site; other site 743721003761 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 743721003762 L-aspartate oxidase; Provisional; Region: PRK06175 743721003763 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 743721003764 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 743721003765 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 743721003766 HTH-like domain; Region: HTH_21; pfam13276 743721003767 Integrase core domain; Region: rve; pfam00665 743721003768 Integrase core domain; Region: rve_3; pfam13683 743721003769 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 743721003770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721003771 active site 743721003772 phosphorylation site [posttranslational modification] 743721003773 intermolecular recognition site; other site 743721003774 dimerization interface [polypeptide binding]; other site 743721003775 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743721003776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743721003777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721003778 dimer interface [polypeptide binding]; other site 743721003779 phosphorylation site [posttranslational modification] 743721003780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721003781 ATP binding site [chemical binding]; other site 743721003782 Mg2+ binding site [ion binding]; other site 743721003783 G-X-G motif; other site 743721003784 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 743721003785 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 743721003786 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 743721003787 Subunit I/III interface [polypeptide binding]; other site 743721003788 Subunit III/IV interface [polypeptide binding]; other site 743721003789 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743721003790 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 743721003791 D-pathway; other site 743721003792 Putative ubiquinol binding site [chemical binding]; other site 743721003793 Low-spin heme (heme b) binding site [chemical binding]; other site 743721003794 Putative water exit pathway; other site 743721003795 Binuclear center (heme o3/CuB) [ion binding]; other site 743721003796 K-pathway; other site 743721003797 Putative proton exit pathway; other site 743721003798 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 743721003799 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 743721003800 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 743721003801 metabolite-proton symporter; Region: 2A0106; TIGR00883 743721003802 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 743721003803 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 743721003804 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743721003805 FtsX-like permease family; Region: FtsX; pfam02687 743721003806 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 743721003807 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743721003808 Walker A/P-loop; other site 743721003809 ATP binding site [chemical binding]; other site 743721003810 Q-loop/lid; other site 743721003811 ABC transporter signature motif; other site 743721003812 Walker B; other site 743721003813 D-loop; other site 743721003814 H-loop/switch region; other site 743721003815 Rdx family; Region: Rdx; cl01407 743721003816 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 743721003817 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 743721003818 Competence protein; Region: Competence; pfam03772 743721003819 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743721003820 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 743721003821 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 743721003822 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743721003823 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 743721003824 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743721003825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721003826 Walker A/P-loop; other site 743721003827 ATP binding site [chemical binding]; other site 743721003828 Q-loop/lid; other site 743721003829 ABC transporter signature motif; other site 743721003830 Walker B; other site 743721003831 D-loop; other site 743721003832 H-loop/switch region; other site 743721003833 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 743721003834 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 743721003835 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 743721003836 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 743721003837 Ligand binding site; other site 743721003838 oligomer interface; other site 743721003839 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 743721003840 Low molecular weight phosphatase family; Region: LMWPc; cd00115 743721003841 active site 743721003842 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743721003843 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743721003844 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 743721003845 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 743721003846 GIY-YIG motif/motif A; other site 743721003847 active site 743721003848 catalytic site [active] 743721003849 putative DNA binding site [nucleotide binding]; other site 743721003850 metal binding site [ion binding]; metal-binding site 743721003851 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 743721003852 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 743721003853 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743721003854 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743721003855 DNA binding site [nucleotide binding] 743721003856 domain linker motif; other site 743721003857 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 743721003858 putative dimerization interface [polypeptide binding]; other site 743721003859 putative ligand binding site [chemical binding]; other site 743721003860 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 743721003861 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 743721003862 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 743721003863 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 743721003864 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 743721003865 active site 743721003866 FMN binding site [chemical binding]; other site 743721003867 substrate binding site [chemical binding]; other site 743721003868 3Fe-4S cluster binding site [ion binding]; other site 743721003869 CHASE3 domain; Region: CHASE3; pfam05227 743721003870 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743721003871 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721003872 putative active site [active] 743721003873 heme pocket [chemical binding]; other site 743721003874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721003875 dimer interface [polypeptide binding]; other site 743721003876 phosphorylation site [posttranslational modification] 743721003877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721003878 ATP binding site [chemical binding]; other site 743721003879 Mg2+ binding site [ion binding]; other site 743721003880 G-X-G motif; other site 743721003881 Response regulator receiver domain; Region: Response_reg; pfam00072 743721003882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721003883 active site 743721003884 phosphorylation site [posttranslational modification] 743721003885 intermolecular recognition site; other site 743721003886 dimerization interface [polypeptide binding]; other site 743721003887 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743721003888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721003889 active site 743721003890 phosphorylation site [posttranslational modification] 743721003891 intermolecular recognition site; other site 743721003892 dimerization interface [polypeptide binding]; other site 743721003893 sensor protein ZraS; Provisional; Region: PRK10364 743721003894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721003895 ATP binding site [chemical binding]; other site 743721003896 G-X-G motif; other site 743721003897 Response regulator receiver domain; Region: Response_reg; pfam00072 743721003898 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 743721003899 MG2 domain; Region: A2M_N; pfam01835 743721003900 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 743721003901 surface patch; other site 743721003902 thioester region; other site 743721003903 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743721003904 DNA-binding site [nucleotide binding]; DNA binding site 743721003905 RNA-binding motif; other site 743721003906 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 743721003907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743721003908 active site 743721003909 beta-hexosaminidase; Provisional; Region: PRK05337 743721003910 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 743721003911 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 743721003912 putative active site [active] 743721003913 putative metal binding residues [ion binding]; other site 743721003914 signature motif; other site 743721003915 putative dimer interface [polypeptide binding]; other site 743721003916 putative phosphate binding site [ion binding]; other site 743721003917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721003918 putative active site [active] 743721003919 heme pocket [chemical binding]; other site 743721003920 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721003921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721003922 metal binding site [ion binding]; metal-binding site 743721003923 active site 743721003924 I-site; other site 743721003925 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743721003926 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 743721003927 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743721003928 active site 743721003929 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 743721003930 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743721003931 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 743721003932 Walker A/P-loop; other site 743721003933 ATP binding site [chemical binding]; other site 743721003934 Q-loop/lid; other site 743721003935 ABC transporter signature motif; other site 743721003936 Walker B; other site 743721003937 D-loop; other site 743721003938 H-loop/switch region; other site 743721003939 Uncharacterized conserved protein [Function unknown]; Region: COG1739 743721003940 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 743721003941 RNA polymerase sigma factor; Provisional; Region: PRK12513 743721003942 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743721003943 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743721003944 DNA binding residues [nucleotide binding] 743721003945 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743721003946 GAF domain; Region: GAF; cl17456 743721003947 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743721003948 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 743721003949 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721003950 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721003951 metal binding site [ion binding]; metal-binding site 743721003952 active site 743721003953 I-site; other site 743721003954 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743721003955 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743721003956 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 743721003957 NAD(P) binding site [chemical binding]; other site 743721003958 catalytic residues [active] 743721003959 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 743721003960 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 743721003961 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 743721003962 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 743721003963 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 743721003964 active site 743721003965 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 743721003966 active site 743721003967 catalytic triad [active] 743721003968 oxyanion hole [active] 743721003969 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 743721003970 hypothetical protein; Provisional; Region: PRK09040 743721003971 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743721003972 ligand binding site [chemical binding]; other site 743721003973 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 743721003974 ribonuclease D; Region: rnd; TIGR01388 743721003975 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 743721003976 catalytic site [active] 743721003977 putative active site [active] 743721003978 putative substrate binding site [chemical binding]; other site 743721003979 Uncharacterized conserved protein [Function unknown]; Region: COG1262 743721003980 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 743721003981 Peptidase family M48; Region: Peptidase_M48; pfam01435 743721003982 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 743721003983 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 743721003984 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 743721003985 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 743721003986 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 743721003987 NAD(P) binding site [chemical binding]; other site 743721003988 homotetramer interface [polypeptide binding]; other site 743721003989 homodimer interface [polypeptide binding]; other site 743721003990 active site 743721003991 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 743721003992 active site 743721003993 HIGH motif; other site 743721003994 nucleotide binding site [chemical binding]; other site 743721003995 KMSKS motif; other site 743721003996 heat shock protein HtpX; Provisional; Region: PRK05457 743721003997 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 743721003998 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 743721003999 intracellular protease, PfpI family; Region: PfpI; TIGR01382 743721004000 proposed catalytic triad [active] 743721004001 conserved cys residue [active] 743721004002 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 743721004003 putative active site [active] 743721004004 Zn binding site [ion binding]; other site 743721004005 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 743721004006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721004007 POT family; Region: PTR2; cl17359 743721004008 Rhomboid family; Region: Rhomboid; pfam01694 743721004009 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 743721004010 Predicted acetyltransferase [General function prediction only]; Region: COG2388 743721004011 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 743721004012 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 743721004013 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 743721004014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721004015 S-adenosylmethionine binding site [chemical binding]; other site 743721004016 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 743721004017 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 743721004018 active site 743721004019 Zn binding site [ion binding]; other site 743721004020 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743721004021 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 743721004022 FAD binding pocket [chemical binding]; other site 743721004023 FAD binding motif [chemical binding]; other site 743721004024 phosphate binding motif [ion binding]; other site 743721004025 beta-alpha-beta structure motif; other site 743721004026 NAD binding pocket [chemical binding]; other site 743721004027 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 743721004028 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 743721004029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721004030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743721004031 Walker A/P-loop; other site 743721004032 ATP binding site [chemical binding]; other site 743721004033 Q-loop/lid; other site 743721004034 ABC transporter signature motif; other site 743721004035 Walker B; other site 743721004036 D-loop; other site 743721004037 H-loop/switch region; other site 743721004038 Cytochrome c553 [Energy production and conversion]; Region: COG2863 743721004039 Cytochrome c553 [Energy production and conversion]; Region: COG2863 743721004040 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743721004041 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743721004042 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721004043 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743721004044 Protein export membrane protein; Region: SecD_SecF; cl14618 743721004045 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743721004046 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 743721004047 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 743721004048 putative active site; other site 743721004049 catalytic triad [active] 743721004050 putative dimer interface [polypeptide binding]; other site 743721004051 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 743721004052 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 743721004053 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 743721004054 cytidylate kinase; Provisional; Region: cmk; PRK00023 743721004055 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 743721004056 CMP-binding site; other site 743721004057 The sites determining sugar specificity; other site 743721004058 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 743721004059 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 743721004060 RNA binding site [nucleotide binding]; other site 743721004061 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 743721004062 RNA binding site [nucleotide binding]; other site 743721004063 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 743721004064 RNA binding site [nucleotide binding]; other site 743721004065 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743721004066 RNA binding site [nucleotide binding]; other site 743721004067 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743721004068 RNA binding site [nucleotide binding]; other site 743721004069 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 743721004070 RNA binding site [nucleotide binding]; other site 743721004071 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743721004072 IHF dimer interface [polypeptide binding]; other site 743721004073 IHF - DNA interface [nucleotide binding]; other site 743721004074 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 743721004075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721004076 binding surface 743721004077 TPR motif; other site 743721004078 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 743721004079 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 743721004080 Mg++ binding site [ion binding]; other site 743721004081 putative catalytic motif [active] 743721004082 putative substrate binding site [chemical binding]; other site 743721004083 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 743721004084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721004085 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 743721004086 NAD(P) binding site [chemical binding]; other site 743721004087 homodimer interface [polypeptide binding]; other site 743721004088 substrate binding site [chemical binding]; other site 743721004089 active site 743721004090 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 743721004091 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 743721004092 active site 743721004093 tetramer interface; other site 743721004094 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 743721004095 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743721004096 dimer interface [polypeptide binding]; other site 743721004097 active site 743721004098 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 743721004099 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 743721004100 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743721004101 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 743721004102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743721004103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743721004104 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 743721004105 active site 743721004106 multimer interface [polypeptide binding]; other site 743721004107 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 743721004108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721004109 FeS/SAM binding site; other site 743721004110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721004111 TPR motif; other site 743721004112 binding surface 743721004113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743721004114 non-specific DNA binding site [nucleotide binding]; other site 743721004115 salt bridge; other site 743721004116 sequence-specific DNA binding site [nucleotide binding]; other site 743721004117 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 743721004118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 743721004119 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 743721004120 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 743721004121 Trp docking motif [polypeptide binding]; other site 743721004122 active site 743721004123 GTP-binding protein Der; Reviewed; Region: PRK00093 743721004124 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 743721004125 G1 box; other site 743721004126 GTP/Mg2+ binding site [chemical binding]; other site 743721004127 Switch I region; other site 743721004128 G2 box; other site 743721004129 Switch II region; other site 743721004130 G3 box; other site 743721004131 G4 box; other site 743721004132 G5 box; other site 743721004133 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 743721004134 G1 box; other site 743721004135 GTP/Mg2+ binding site [chemical binding]; other site 743721004136 Switch I region; other site 743721004137 G2 box; other site 743721004138 G3 box; other site 743721004139 Switch II region; other site 743721004140 G4 box; other site 743721004141 G5 box; other site 743721004142 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 743721004143 GTP binding site; other site 743721004144 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 743721004145 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 743721004146 dimer interface [polypeptide binding]; other site 743721004147 putative functional site; other site 743721004148 putative MPT binding site; other site 743721004149 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 743721004150 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 743721004151 active site residue [active] 743721004152 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 743721004153 ATP binding site [chemical binding]; other site 743721004154 substrate interface [chemical binding]; other site 743721004155 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 743721004156 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 743721004157 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 743721004158 TrkA-N domain; Region: TrkA_N; pfam02254 743721004159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 743721004160 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 743721004161 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 743721004162 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 743721004163 homodimer interface [polypeptide binding]; other site 743721004164 NADP binding site [chemical binding]; other site 743721004165 substrate binding site [chemical binding]; other site 743721004166 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 743721004167 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 743721004168 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743721004169 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 743721004170 D-pathway; other site 743721004171 Putative ubiquinol binding site [chemical binding]; other site 743721004172 Low-spin heme (heme b) binding site [chemical binding]; other site 743721004173 Putative water exit pathway; other site 743721004174 Binuclear center (heme o3/CuB) [ion binding]; other site 743721004175 K-pathway; other site 743721004176 Putative proton exit pathway; other site 743721004177 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 743721004178 Subunit I/III interface [polypeptide binding]; other site 743721004179 Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990 743721004180 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 743721004181 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 743721004182 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 743721004183 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 743721004184 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 743721004185 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 743721004186 active site 743721004187 GMP synthase; Reviewed; Region: guaA; PRK00074 743721004188 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 743721004189 AMP/PPi binding site [chemical binding]; other site 743721004190 candidate oxyanion hole; other site 743721004191 catalytic triad [active] 743721004192 potential glutamine specificity residues [chemical binding]; other site 743721004193 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 743721004194 ATP Binding subdomain [chemical binding]; other site 743721004195 Ligand Binding sites [chemical binding]; other site 743721004196 Dimerization subdomain; other site 743721004197 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 743721004198 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 743721004199 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 743721004200 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 743721004201 active site 743721004202 DNA binding site [nucleotide binding] 743721004203 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 743721004204 DNA binding site [nucleotide binding] 743721004205 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 743721004206 nucleotide binding site [chemical binding]; other site 743721004207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721004208 PAS domain; Region: PAS_9; pfam13426 743721004209 putative active site [active] 743721004210 heme pocket [chemical binding]; other site 743721004211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743721004212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721004213 ATP binding site [chemical binding]; other site 743721004214 G-X-G motif; other site 743721004215 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743721004216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721004217 active site 743721004218 phosphorylation site [posttranslational modification] 743721004219 intermolecular recognition site; other site 743721004220 dimerization interface [polypeptide binding]; other site 743721004221 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743721004222 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 743721004223 putative acyl-acceptor binding pocket; other site 743721004224 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 743721004225 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743721004226 Flagellin N-methylase; Region: FliB; pfam03692 743721004227 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 743721004228 putative active site [active] 743721004229 Zn binding site [ion binding]; other site 743721004230 HDOD domain; Region: HDOD; pfam08668 743721004231 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 743721004232 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721004233 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721004234 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743721004235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721004236 NAD(P) binding site [chemical binding]; other site 743721004237 active site 743721004238 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 743721004239 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 743721004240 Predicted membrane protein [Function unknown]; Region: COG3650 743721004241 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 743721004242 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 743721004243 PhnA protein; Region: PhnA; pfam03831 743721004244 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743721004245 active site 743721004246 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743721004247 catalytic tetrad [active] 743721004248 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 743721004249 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 743721004250 potential catalytic triad [active] 743721004251 conserved cys residue [active] 743721004252 Protease inhibitor Inh; Region: Inh; pfam02974 743721004253 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743721004254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721004255 Coenzyme A binding pocket [chemical binding]; other site 743721004256 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 743721004257 nucleoside/Zn binding site; other site 743721004258 dimer interface [polypeptide binding]; other site 743721004259 catalytic motif [active] 743721004260 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 743721004261 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 743721004262 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 743721004263 catalytic site [active] 743721004264 putative active site [active] 743721004265 putative substrate binding site [chemical binding]; other site 743721004266 dimer interface [polypeptide binding]; other site 743721004267 phosphoenolpyruvate synthase; Validated; Region: PRK06464 743721004268 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 743721004269 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 743721004270 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 743721004271 PEP synthetase regulatory protein; Provisional; Region: PRK05339 743721004272 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 743721004273 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 743721004274 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 743721004275 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743721004276 DNA-binding site [nucleotide binding]; DNA binding site 743721004277 RNA-binding motif; other site 743721004278 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743721004279 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 743721004280 putative C-terminal domain interface [polypeptide binding]; other site 743721004281 putative GSH binding site (G-site) [chemical binding]; other site 743721004282 putative dimer interface [polypeptide binding]; other site 743721004283 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 743721004284 putative N-terminal domain interface [polypeptide binding]; other site 743721004285 putative dimer interface [polypeptide binding]; other site 743721004286 putative substrate binding pocket (H-site) [chemical binding]; other site 743721004287 Uncharacterized conserved protein [Function unknown]; Region: COG0397 743721004288 hypothetical protein; Validated; Region: PRK00029 743721004289 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743721004290 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 743721004291 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743721004292 ATP binding site [chemical binding]; other site 743721004293 Mg++ binding site [ion binding]; other site 743721004294 motif III; other site 743721004295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721004296 nucleotide binding region [chemical binding]; other site 743721004297 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 743721004298 putative RNA binding site [nucleotide binding]; other site 743721004299 ABC transporter ATPase component; Reviewed; Region: PRK11147 743721004300 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 743721004301 Walker A/P-loop; other site 743721004302 ATP binding site [chemical binding]; other site 743721004303 Q-loop/lid; other site 743721004304 ABC transporter signature motif; other site 743721004305 Walker B; other site 743721004306 D-loop; other site 743721004307 H-loop/switch region; other site 743721004308 ABC transporter; Region: ABC_tran_2; pfam12848 743721004309 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743721004310 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 743721004311 putative hydrophobic ligand binding site [chemical binding]; other site 743721004312 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 743721004313 putative RNAase interaction site [polypeptide binding]; other site 743721004314 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 743721004315 active site 743721004316 barstar interaction site; other site 743721004317 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 743721004318 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 743721004319 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 743721004320 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 743721004321 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743721004322 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743721004323 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721004324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743721004325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743721004326 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 743721004327 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 743721004328 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 743721004329 ATP-NAD kinase; Region: NAD_kinase; pfam01513 743721004330 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 743721004331 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 743721004332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721004333 active site 743721004334 phosphorylation site [posttranslational modification] 743721004335 intermolecular recognition site; other site 743721004336 dimerization interface [polypeptide binding]; other site 743721004337 CheB methylesterase; Region: CheB_methylest; pfam01339 743721004338 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 743721004339 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 743721004340 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 743721004341 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 743721004342 PAS domain; Region: PAS_9; pfam13426 743721004343 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743721004344 dimer interface [polypeptide binding]; other site 743721004345 putative CheW interface [polypeptide binding]; other site 743721004346 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 743721004347 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743721004348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743721004349 dimerization interface [polypeptide binding]; other site 743721004350 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743721004351 dimer interface [polypeptide binding]; other site 743721004352 putative CheW interface [polypeptide binding]; other site 743721004353 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743721004354 HAMP domain; Region: HAMP; pfam00672 743721004355 PAS domain; Region: PAS_8; pfam13188 743721004356 PAS domain; Region: PAS_9; pfam13426 743721004357 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743721004358 dimer interface [polypeptide binding]; other site 743721004359 putative CheW interface [polypeptide binding]; other site 743721004360 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 743721004361 putative CheA interaction surface; other site 743721004362 Flagellar regulator YcgR; Region: YcgR; pfam07317 743721004363 PilZ domain; Region: PilZ; pfam07238 743721004364 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 743721004365 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743721004366 putative binding surface; other site 743721004367 active site 743721004368 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 743721004369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721004370 ATP binding site [chemical binding]; other site 743721004371 Mg2+ binding site [ion binding]; other site 743721004372 G-X-G motif; other site 743721004373 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 743721004374 Response regulator receiver domain; Region: Response_reg; pfam00072 743721004375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721004376 active site 743721004377 phosphorylation site [posttranslational modification] 743721004378 intermolecular recognition site; other site 743721004379 dimerization interface [polypeptide binding]; other site 743721004380 STAS domain; Region: STAS_2; pfam13466 743721004381 CheW-like domain; Region: CheW; pfam01584 743721004382 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743721004383 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 743721004384 P-loop; other site 743721004385 Magnesium ion binding site [ion binding]; other site 743721004386 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743721004387 Magnesium ion binding site [ion binding]; other site 743721004388 flagellar motor protein MotD; Reviewed; Region: PRK09038 743721004389 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 743721004390 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743721004391 ligand binding site [chemical binding]; other site 743721004392 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 743721004393 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 743721004394 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743721004395 putative binding surface; other site 743721004396 active site 743721004397 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 743721004398 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 743721004399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721004400 ATP binding site [chemical binding]; other site 743721004401 Mg2+ binding site [ion binding]; other site 743721004402 G-X-G motif; other site 743721004403 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 743721004404 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 743721004405 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 743721004406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721004407 active site 743721004408 phosphorylation site [posttranslational modification] 743721004409 intermolecular recognition site; other site 743721004410 dimerization interface [polypeptide binding]; other site 743721004411 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 743721004412 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743721004413 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 743721004414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743721004415 DNA binding residues [nucleotide binding] 743721004416 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 743721004417 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 743721004418 P-loop; other site 743721004419 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 743721004420 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 743721004421 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743721004422 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 743721004423 FHIPEP family; Region: FHIPEP; pfam00771 743721004424 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 743721004425 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 743721004426 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 743721004427 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 743721004428 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 743721004429 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 743721004430 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 743721004431 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 743721004432 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 743721004433 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 743721004434 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 743721004435 Flagellar FliJ protein; Region: FliJ; pfam02050 743721004436 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 743721004437 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743721004438 Walker A motif; other site 743721004439 ATP binding site [chemical binding]; other site 743721004440 Walker B motif; other site 743721004441 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 743721004442 Flagellar assembly protein FliH; Region: FliH; pfam02108 743721004443 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 743721004444 MgtE intracellular N domain; Region: MgtE_N; smart00924 743721004445 FliG C-terminal domain; Region: FliG_C; pfam01706 743721004446 flagellar MS-ring protein; Reviewed; Region: fliF; PRK12800 743721004447 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 743721004448 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 743721004449 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 743721004450 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 743721004451 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 743721004452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721004453 Walker A motif; other site 743721004454 ATP binding site [chemical binding]; other site 743721004455 Walker B motif; other site 743721004456 arginine finger; other site 743721004457 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743721004458 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743721004459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721004460 active site 743721004461 phosphorylation site [posttranslational modification] 743721004462 intermolecular recognition site; other site 743721004463 dimerization interface [polypeptide binding]; other site 743721004464 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 743721004465 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 743721004466 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 743721004467 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743721004468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721004469 active site 743721004470 phosphorylation site [posttranslational modification] 743721004471 intermolecular recognition site; other site 743721004472 dimerization interface [polypeptide binding]; other site 743721004473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743721004474 DNA binding residues [nucleotide binding] 743721004475 dimerization interface [polypeptide binding]; other site 743721004476 flagellar protein FliS; Validated; Region: fliS; PRK05685 743721004477 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 743721004478 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 743721004479 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 743721004480 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 743721004481 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743721004482 active site 743721004483 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743721004484 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 743721004485 active site 743721004486 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743721004487 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 743721004488 Probable Catalytic site; other site 743721004489 metal-binding site 743721004490 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 743721004491 flagellin; Provisional; Region: PRK12802 743721004492 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 743721004493 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 743721004494 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 743721004495 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 743721004496 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 743721004497 flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12714 743721004498 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 743721004499 flagellar rod assembly protein/muramidase FlgJ; Reviewed; Region: flgJ; PRK12711 743721004500 Rod binding protein; Region: Rod-binding; cl01626 743721004501 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 743721004502 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 743721004503 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 743721004504 Flagellar L-ring protein; Region: FlgH; pfam02107 743721004505 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 743721004506 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743721004507 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 743721004508 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 743721004509 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 743721004510 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 743721004511 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 743721004512 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 743721004513 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743721004514 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634 743721004515 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 743721004516 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 743721004517 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12629 743721004518 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 743721004519 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743721004520 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12620 743721004521 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 743721004522 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 743721004523 Response regulator receiver domain; Region: Response_reg; pfam00072 743721004524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721004525 active site 743721004526 phosphorylation site [posttranslational modification] 743721004527 intermolecular recognition site; other site 743721004528 dimerization interface [polypeptide binding]; other site 743721004529 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 743721004530 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 743721004531 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 743721004532 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743721004533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 743721004534 dimer interface [polypeptide binding]; other site 743721004535 phosphorylation site [posttranslational modification] 743721004536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721004537 ATP binding site [chemical binding]; other site 743721004538 Mg2+ binding site [ion binding]; other site 743721004539 G-X-G motif; other site 743721004540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721004541 metal binding site [ion binding]; metal-binding site 743721004542 active site 743721004543 I-site; other site 743721004544 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743721004545 Response regulator receiver domain; Region: Response_reg; pfam00072 743721004546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721004547 active site 743721004548 phosphorylation site [posttranslational modification] 743721004549 intermolecular recognition site; other site 743721004550 dimerization interface [polypeptide binding]; other site 743721004551 PAS fold; Region: PAS_4; pfam08448 743721004552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721004553 putative active site [active] 743721004554 heme pocket [chemical binding]; other site 743721004555 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743721004556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721004557 putative active site [active] 743721004558 heme pocket [chemical binding]; other site 743721004559 Histidine kinase; Region: HisKA_3; pfam07730 743721004560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721004561 ATP binding site [chemical binding]; other site 743721004562 Mg2+ binding site [ion binding]; other site 743721004563 G-X-G motif; other site 743721004564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721004565 PAS fold; Region: PAS_3; pfam08447 743721004566 putative active site [active] 743721004567 heme pocket [chemical binding]; other site 743721004568 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 743721004569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743721004570 putative active site [active] 743721004571 heme pocket [chemical binding]; other site 743721004572 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721004573 metal binding site [ion binding]; metal-binding site 743721004574 active site 743721004575 I-site; other site 743721004576 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743721004577 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743721004578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743721004579 dimer interface [polypeptide binding]; other site 743721004580 putative CheW interface [polypeptide binding]; other site 743721004581 putative lysogenization regulator; Reviewed; Region: PRK00218 743721004582 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 743721004583 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 743721004584 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 743721004585 nudix motif; other site 743721004586 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 743721004587 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 743721004588 Clp amino terminal domain; Region: Clp_N; pfam02861 743721004589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721004590 Walker A motif; other site 743721004591 ATP binding site [chemical binding]; other site 743721004592 Walker B motif; other site 743721004593 arginine finger; other site 743721004594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721004595 Walker A motif; other site 743721004596 ATP binding site [chemical binding]; other site 743721004597 Walker B motif; other site 743721004598 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 743721004599 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 743721004600 rRNA binding site [nucleotide binding]; other site 743721004601 predicted 30S ribosome binding site; other site 743721004602 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 743721004603 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 743721004604 Protein of unknown function, DUF482; Region: DUF482; pfam04339 743721004605 thioredoxin reductase; Provisional; Region: PRK10262 743721004606 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743721004607 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743721004608 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 743721004609 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 743721004610 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 743721004611 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 743721004612 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 743721004613 recombination factor protein RarA; Reviewed; Region: PRK13342 743721004614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721004615 Walker A motif; other site 743721004616 ATP binding site [chemical binding]; other site 743721004617 Walker B motif; other site 743721004618 arginine finger; other site 743721004619 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 743721004620 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743721004621 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 743721004622 Integrase core domain; Region: rve; pfam00665 743721004623 Integrase core domain; Region: rve_3; cl15866 743721004624 short chain dehydrogenase; Provisional; Region: PRK06180 743721004625 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 743721004626 NADP binding site [chemical binding]; other site 743721004627 active site 743721004628 steroid binding site; other site 743721004629 Cupin; Region: Cupin_6; pfam12852 743721004630 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743721004631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743721004632 rhodanese superfamily protein; Provisional; Region: PRK05320 743721004633 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 743721004634 active site residue [active] 743721004635 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 743721004636 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 743721004637 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743721004638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743721004639 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 743721004640 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 743721004641 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 743721004642 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 743721004643 homotrimer interaction site [polypeptide binding]; other site 743721004644 putative active site [active] 743721004645 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 743721004646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721004647 binding surface 743721004648 TPR repeat; Region: TPR_11; pfam13414 743721004649 TPR motif; other site 743721004650 TPR repeat; Region: TPR_11; pfam13414 743721004651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721004652 binding surface 743721004653 TPR motif; other site 743721004654 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743721004655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721004656 TPR repeat; Region: TPR_11; pfam13414 743721004657 binding surface 743721004658 TPR motif; other site 743721004659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721004660 binding surface 743721004661 TPR repeat; Region: TPR_11; pfam13414 743721004662 TPR motif; other site 743721004663 S4 domain; Region: S4_2; pfam13275 743721004664 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743721004665 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743721004666 hypothetical protein; Provisional; Region: PRK11019 743721004667 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 743721004668 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 743721004669 DNA binding residues [nucleotide binding] 743721004670 dimer interface [polypeptide binding]; other site 743721004671 copper binding site [ion binding]; other site 743721004672 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743721004673 metal-binding site [ion binding] 743721004674 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743721004675 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743721004676 metal-binding site [ion binding] 743721004677 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743721004678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721004679 motif II; other site 743721004680 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 743721004681 dimer interface [polypeptide binding]; other site 743721004682 catalytic triad [active] 743721004683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743721004684 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721004685 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 743721004686 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743721004687 FtsX-like permease family; Region: FtsX; pfam02687 743721004688 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743721004689 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743721004690 Walker A/P-loop; other site 743721004691 ATP binding site [chemical binding]; other site 743721004692 Q-loop/lid; other site 743721004693 ABC transporter signature motif; other site 743721004694 Walker B; other site 743721004695 D-loop; other site 743721004696 H-loop/switch region; other site 743721004697 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 743721004698 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 743721004699 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 743721004700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721004701 NAD(P) binding site [chemical binding]; other site 743721004702 active site 743721004703 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 743721004704 dimer interface [polypeptide binding]; other site 743721004705 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 743721004706 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 743721004707 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721004708 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721004709 metal binding site [ion binding]; metal-binding site 743721004710 active site 743721004711 I-site; other site 743721004712 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 743721004713 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 743721004714 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 743721004715 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 743721004716 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 743721004717 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721004718 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 743721004719 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 743721004720 nucleotide binding site [chemical binding]; other site 743721004721 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 743721004722 NIPSNAP; Region: NIPSNAP; pfam07978 743721004723 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 743721004724 helix-hairpin-helix signature motif; other site 743721004725 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 743721004726 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 743721004727 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743721004728 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 743721004729 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 743721004730 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 743721004731 FMN binding site [chemical binding]; other site 743721004732 active site 743721004733 substrate binding site [chemical binding]; other site 743721004734 catalytic residue [active] 743721004735 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 743721004736 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743721004737 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743721004738 active site 743721004739 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 743721004740 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 743721004741 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743721004742 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 743721004743 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743721004744 PhoD-like phosphatase; Region: PhoD; pfam09423 743721004745 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 743721004746 putative active site [active] 743721004747 putative metal binding site [ion binding]; other site 743721004748 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 743721004749 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 743721004750 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721004751 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721004752 Domain of unknown function (DU1801); Region: DUF1801; cl17490 743721004753 Restriction endonuclease; Region: Mrr_cat; pfam04471 743721004754 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 743721004755 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 743721004756 cofactor binding site; other site 743721004757 DNA binding site [nucleotide binding] 743721004758 substrate interaction site [chemical binding]; other site 743721004759 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 743721004760 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 743721004761 additional DNA contacts [nucleotide binding]; other site 743721004762 mismatch recognition site; other site 743721004763 active site 743721004764 zinc binding site [ion binding]; other site 743721004765 DNA intercalation site [nucleotide binding]; other site 743721004766 YhhN-like protein; Region: YhhN; pfam07947 743721004767 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 743721004768 dimer interface [polypeptide binding]; other site 743721004769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743721004770 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 743721004771 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 743721004772 active site 743721004773 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 743721004774 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 743721004775 Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662 743721004776 NOSIC (NUC001) domain; Region: NOSIC; cl06890 743721004777 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 743721004778 Transposase IS200 like; Region: Y1_Tnp; pfam01797 743721004779 Protein of unknown function DUF262; Region: DUF262; pfam03235 743721004780 Uncharacterized conserved protein [Function unknown]; Region: COG1479 743721004781 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 743721004782 DNA methylase; Region: N6_N4_Mtase; cl17433 743721004783 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 743721004784 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 743721004785 B12 binding site [chemical binding]; other site 743721004786 cobalt ligand [ion binding]; other site 743721004787 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743721004788 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 743721004789 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 743721004790 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743721004791 Serine hydrolase; Region: Ser_hydrolase; cl17834 743721004792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743721004793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743721004794 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 743721004795 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 743721004796 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 743721004797 NAD binding site [chemical binding]; other site 743721004798 Phe binding site; other site 743721004799 isovaleryl-CoA dehydrogenase; Region: PLN02519 743721004800 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 743721004801 substrate binding site [chemical binding]; other site 743721004802 FAD binding site [chemical binding]; other site 743721004803 catalytic base [active] 743721004804 Transposase domain (DUF772); Region: DUF772; pfam05598 743721004805 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 743721004806 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 743721004807 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 743721004808 catalytic triad [active] 743721004809 putative active site [active] 743721004810 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 743721004811 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 743721004812 Autotransporter beta-domain; Region: Autotransporter; pfam03797 743721004813 putative acyltransferase; Provisional; Region: PRK05790 743721004814 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743721004815 dimer interface [polypeptide binding]; other site 743721004816 active site 743721004817 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 743721004818 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 743721004819 short chain dehydrogenase; Provisional; Region: PRK06123 743721004820 classical (c) SDRs; Region: SDR_c; cd05233 743721004821 NAD(P) binding site [chemical binding]; other site 743721004822 active site 743721004823 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 743721004824 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 743721004825 ferrous iron transporter FeoB; Region: feoB; TIGR00437 743721004826 G1 box; other site 743721004827 GTP/Mg2+ binding site [chemical binding]; other site 743721004828 Switch I region; other site 743721004829 G2 box; other site 743721004830 G3 box; other site 743721004831 Switch II region; other site 743721004832 G4 box; other site 743721004833 G5 box; other site 743721004834 Nucleoside recognition; Region: Gate; pfam07670 743721004835 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 743721004836 Nucleoside recognition; Region: Gate; pfam07670 743721004837 FeoA domain; Region: FeoA; pfam04023 743721004838 enoyl-CoA hydratase; Provisional; Region: PRK05995 743721004839 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743721004840 substrate binding site [chemical binding]; other site 743721004841 oxyanion hole (OAH) forming residues; other site 743721004842 trimer interface [polypeptide binding]; other site 743721004843 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 743721004844 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743721004845 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 743721004846 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 743721004847 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743721004848 carboxyltransferase (CT) interaction site; other site 743721004849 biotinylation site [posttranslational modification]; other site 743721004850 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 743721004851 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 743721004852 active site 743721004853 catalytic residues [active] 743721004854 metal binding site [ion binding]; metal-binding site 743721004855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 743721004856 MOSC domain; Region: MOSC; pfam03473 743721004857 3-alpha domain; Region: 3-alpha; pfam03475 743721004858 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 743721004859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743721004860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721004861 homodimer interface [polypeptide binding]; other site 743721004862 catalytic residue [active] 743721004863 prephenate dehydrogenase; Provisional; Region: PRK08818 743721004864 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743721004865 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 743721004866 dimer interface [polypeptide binding]; other site 743721004867 pyridoxamine kinase; Validated; Region: PRK05756 743721004868 pyridoxal binding site [chemical binding]; other site 743721004869 ATP binding site [chemical binding]; other site 743721004870 chaperone protein DnaJ; Provisional; Region: PRK10767 743721004871 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743721004872 HSP70 interaction site [polypeptide binding]; other site 743721004873 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 743721004874 Zn binding sites [ion binding]; other site 743721004875 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 743721004876 dimer interface [polypeptide binding]; other site 743721004877 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 743721004878 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 743721004879 nucleotide binding site [chemical binding]; other site 743721004880 GrpE; Region: GrpE; pfam01025 743721004881 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 743721004882 dimer interface [polypeptide binding]; other site 743721004883 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 743721004884 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 743721004885 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 743721004886 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 743721004887 Walker A/P-loop; other site 743721004888 ATP binding site [chemical binding]; other site 743721004889 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 743721004890 ABC transporter signature motif; other site 743721004891 Walker B; other site 743721004892 D-loop; other site 743721004893 H-loop/switch region; other site 743721004894 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 743721004895 metal binding site 2 [ion binding]; metal-binding site 743721004896 putative DNA binding helix; other site 743721004897 metal binding site 1 [ion binding]; metal-binding site 743721004898 dimer interface [polypeptide binding]; other site 743721004899 structural Zn2+ binding site [ion binding]; other site 743721004900 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 743721004901 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 743721004902 hypothetical protein; Validated; Region: PRK01777 743721004903 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 743721004904 putative coenzyme Q binding site [chemical binding]; other site 743721004905 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 743721004906 SmpB-tmRNA interface; other site 743721004907 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 743721004908 Fe-S cluster binding site [ion binding]; other site 743721004909 active site 743721004910 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 743721004911 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 743721004912 MgtC family; Region: MgtC; pfam02308 743721004913 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 743721004914 glucose-1-dehydrogenase; Provisional; Region: PRK06947 743721004915 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 743721004916 NADP binding site [chemical binding]; other site 743721004917 substrate binding site [chemical binding]; other site 743721004918 active site 743721004919 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743721004920 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743721004921 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743721004922 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721004923 LysR family transcriptional regulator; Provisional; Region: PRK14997 743721004924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721004925 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743721004926 putative effector binding pocket; other site 743721004927 dimerization interface [polypeptide binding]; other site 743721004928 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743721004929 ligand binding site [chemical binding]; other site 743721004930 replicative DNA helicase; Provisional; Region: PRK08760 743721004931 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 743721004932 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 743721004933 Walker A motif; other site 743721004934 ATP binding site [chemical binding]; other site 743721004935 Walker B motif; other site 743721004936 DNA binding loops [nucleotide binding] 743721004937 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 743721004938 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 743721004939 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 743721004940 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 743721004941 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 743721004942 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 743721004943 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 743721004944 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 743721004945 putative dimer interface [polypeptide binding]; other site 743721004946 putative anticodon binding site; other site 743721004947 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 743721004948 homodimer interface [polypeptide binding]; other site 743721004949 motif 1; other site 743721004950 motif 2; other site 743721004951 active site 743721004952 motif 3; other site 743721004953 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 743721004954 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 743721004955 active site clefts [active] 743721004956 zinc binding site [ion binding]; other site 743721004957 dimer interface [polypeptide binding]; other site 743721004958 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 743721004959 kynureninase; Region: kynureninase; TIGR01814 743721004960 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 743721004961 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743721004962 catalytic residue [active] 743721004963 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 743721004964 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743721004965 exonuclease I; Provisional; Region: sbcB; PRK11779 743721004966 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 743721004967 active site 743721004968 catalytic site [active] 743721004969 substrate binding site [chemical binding]; other site 743721004970 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 743721004971 TIGR02453 family protein; Region: TIGR02453 743721004972 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 743721004973 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 743721004974 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 743721004975 active site 743721004976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743721004977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 743721004978 putative dimer interface [polypeptide binding]; other site 743721004979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743721004980 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 743721004981 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 743721004982 substrate binding site [chemical binding]; other site 743721004983 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 743721004984 substrate binding site [chemical binding]; other site 743721004985 ligand binding site [chemical binding]; other site 743721004986 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 743721004987 putative active site [active] 743721004988 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 743721004989 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 743721004990 aconitate hydratase; Validated; Region: PRK09277 743721004991 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 743721004992 substrate binding site [chemical binding]; other site 743721004993 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 743721004994 ligand binding site [chemical binding]; other site 743721004995 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 743721004996 substrate binding site [chemical binding]; other site 743721004997 putative long-chain fatty acyl CoA ligase; Provisional; Region: PRK08751 743721004998 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 743721004999 acyl-activating enzyme (AAE) consensus motif; other site 743721005000 putative AMP binding site [chemical binding]; other site 743721005001 putative active site [active] 743721005002 putative CoA binding site [chemical binding]; other site 743721005003 enoyl-CoA hydratase; Validated; Region: PRK08788 743721005004 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743721005005 substrate binding site [chemical binding]; other site 743721005006 oxyanion hole (OAH) forming residues; other site 743721005007 trimer interface [polypeptide binding]; other site 743721005008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743721005009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721005010 dimer interface [polypeptide binding]; other site 743721005011 phosphorylation site [posttranslational modification] 743721005012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721005013 ATP binding site [chemical binding]; other site 743721005014 Mg2+ binding site [ion binding]; other site 743721005015 G-X-G motif; other site 743721005016 Response regulator receiver domain; Region: Response_reg; pfam00072 743721005017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721005018 active site 743721005019 phosphorylation site [posttranslational modification] 743721005020 intermolecular recognition site; other site 743721005021 dimerization interface [polypeptide binding]; other site 743721005022 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743721005023 putative binding surface; other site 743721005024 active site 743721005025 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 743721005026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721005027 active site 743721005028 phosphorylation site [posttranslational modification] 743721005029 intermolecular recognition site; other site 743721005030 dimerization interface [polypeptide binding]; other site 743721005031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743721005032 Zn2+ binding site [ion binding]; other site 743721005033 Mg2+ binding site [ion binding]; other site 743721005034 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 743721005035 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 743721005036 dimer interface [polypeptide binding]; other site 743721005037 putative anticodon binding site; other site 743721005038 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 743721005039 motif 1; other site 743721005040 active site 743721005041 motif 2; other site 743721005042 motif 3; other site 743721005043 peptide chain release factor 2; Provisional; Region: PRK08787 743721005044 This domain is found in peptide chain release factors; Region: PCRF; smart00937 743721005045 RF-1 domain; Region: RF-1; pfam00472 743721005046 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 743721005047 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 743721005048 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 743721005049 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 743721005050 aromatic arch; other site 743721005051 DCoH dimer interaction site [polypeptide binding]; other site 743721005052 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 743721005053 DCoH tetramer interaction site [polypeptide binding]; other site 743721005054 substrate binding site [chemical binding]; other site 743721005055 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743721005056 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 743721005057 zinc transporter ZupT; Provisional; Region: PRK04201 743721005058 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 743721005059 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743721005060 RNA binding surface [nucleotide binding]; other site 743721005061 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 743721005062 active site 743721005063 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 743721005064 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 743721005065 homodimer interface [polypeptide binding]; other site 743721005066 oligonucleotide binding site [chemical binding]; other site 743721005067 response regulator; Provisional; Region: PRK09483 743721005068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721005069 active site 743721005070 phosphorylation site [posttranslational modification] 743721005071 intermolecular recognition site; other site 743721005072 dimerization interface [polypeptide binding]; other site 743721005073 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743721005074 DNA binding residues [nucleotide binding] 743721005075 dimerization interface [polypeptide binding]; other site 743721005076 LysR family transcriptional regulator; Provisional; Region: PRK14997 743721005077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721005078 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 743721005079 putative effector binding pocket; other site 743721005080 putative dimerization interface [polypeptide binding]; other site 743721005081 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 743721005082 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743721005083 seryl-tRNA synthetase; Provisional; Region: PRK05431 743721005084 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 743721005085 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 743721005086 dimer interface [polypeptide binding]; other site 743721005087 active site 743721005088 motif 1; other site 743721005089 motif 2; other site 743721005090 motif 3; other site 743721005091 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743721005092 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 743721005093 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743721005094 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 743721005095 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 743721005096 hinge; other site 743721005097 active site 743721005098 Chorismate mutase type II; Region: CM_2; pfam01817 743721005099 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 743721005100 Prephenate dehydratase; Region: PDT; pfam00800 743721005101 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 743721005102 putative L-Phe binding site [chemical binding]; other site 743721005103 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 743721005104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743721005105 catalytic residue [active] 743721005106 TMAO/DMSO reductase; Reviewed; Region: PRK05363 743721005107 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 743721005108 Moco binding site; other site 743721005109 metal coordination site [ion binding]; other site 743721005110 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 743721005111 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 743721005112 FHA domain; Region: FHA; pfam00498 743721005113 phosphopeptide binding site; other site 743721005114 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 743721005115 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 743721005116 Restriction endonuclease; Region: Mrr_cat; pfam04471 743721005117 DNA gyrase subunit A; Validated; Region: PRK05560 743721005118 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 743721005119 CAP-like domain; other site 743721005120 active site 743721005121 primary dimer interface [polypeptide binding]; other site 743721005122 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743721005123 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743721005124 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743721005125 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743721005126 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743721005127 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743721005128 Predicted transcriptional regulators [Transcription]; Region: COG1725 743721005129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743721005130 DNA-binding site [nucleotide binding]; DNA binding site 743721005131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721005132 Walker A/P-loop; other site 743721005133 ATP binding site [chemical binding]; other site 743721005134 Q-loop/lid; other site 743721005135 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 743721005136 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 743721005137 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 743721005138 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 743721005139 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 743721005140 motif 1; other site 743721005141 dimer interface [polypeptide binding]; other site 743721005142 active site 743721005143 motif 2; other site 743721005144 motif 3; other site 743721005145 Ligase N family; Region: LIGANc; smart00532 743721005146 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 743721005147 nucleotide binding pocket [chemical binding]; other site 743721005148 K-X-D-G motif; other site 743721005149 catalytic site [active] 743721005150 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 743721005151 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 743721005152 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 743721005153 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 743721005154 Dimer interface [polypeptide binding]; other site 743721005155 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 743721005156 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743721005157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721005158 homodimer interface [polypeptide binding]; other site 743721005159 catalytic residue [active] 743721005160 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 743721005161 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743721005162 active site 743721005163 metal binding site [ion binding]; metal-binding site 743721005164 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 743721005165 FtsZ protein binding site [polypeptide binding]; other site 743721005166 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743721005167 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 743721005168 Walker A/P-loop; other site 743721005169 ATP binding site [chemical binding]; other site 743721005170 Q-loop/lid; other site 743721005171 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 743721005172 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 743721005173 ABC transporter signature motif; other site 743721005174 Walker B; other site 743721005175 D-loop; other site 743721005176 H-loop/switch region; other site 743721005177 hypothetical protein; Provisional; Region: PRK09126 743721005178 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743721005179 Predicted flavoprotein [General function prediction only]; Region: COG0431 743721005180 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743721005181 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 743721005182 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 743721005183 active site 743721005184 dimer interface [polypeptide binding]; other site 743721005185 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 743721005186 Ligand Binding Site [chemical binding]; other site 743721005187 Molecular Tunnel; other site 743721005188 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 743721005189 TPP-binding site [chemical binding]; other site 743721005190 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 743721005191 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 743721005192 PYR/PP interface [polypeptide binding]; other site 743721005193 dimer interface [polypeptide binding]; other site 743721005194 TPP binding site [chemical binding]; other site 743721005195 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743721005196 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743721005197 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743721005198 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743721005199 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743721005200 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743721005201 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743721005202 active site 743721005203 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 743721005204 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 743721005205 active site 743721005206 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 743721005207 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 743721005208 putative ATP binding site [chemical binding]; other site 743721005209 putative substrate interface [chemical binding]; other site 743721005210 Cytochrome C' Region: Cytochrom_C_2; cl01610 743721005211 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743721005212 DNA-binding site [nucleotide binding]; DNA binding site 743721005213 RNA-binding motif; other site 743721005214 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 743721005215 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 743721005216 dimerization interface [polypeptide binding]; other site 743721005217 substrate binding site [chemical binding]; other site 743721005218 active site 743721005219 calcium binding site [ion binding]; other site 743721005220 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743721005221 ArsC family; Region: ArsC; pfam03960 743721005222 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743721005223 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 743721005224 C-terminal domain interface [polypeptide binding]; other site 743721005225 GSH binding site (G-site) [chemical binding]; other site 743721005226 dimer interface [polypeptide binding]; other site 743721005227 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 743721005228 dimer interface [polypeptide binding]; other site 743721005229 N-terminal domain interface [polypeptide binding]; other site 743721005230 substrate binding pocket (H-site) [chemical binding]; other site 743721005231 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 743721005232 Fumarase C-terminus; Region: Fumerase_C; pfam05683 743721005233 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 743721005234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743721005235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743721005236 DNA binding residues [nucleotide binding] 743721005237 Uncharacterized conserved protein [Function unknown]; Region: COG2128 743721005238 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 743721005239 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 743721005240 LytTr DNA-binding domain; Region: LytTR; smart00850 743721005241 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 743721005242 Acyltransferase family; Region: Acyl_transf_3; pfam01757 743721005243 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 743721005244 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 743721005245 DHH family; Region: DHH; pfam01368 743721005246 DHHA1 domain; Region: DHHA1; pfam02272 743721005247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 743721005248 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 743721005249 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 743721005250 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743721005251 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 743721005252 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743721005253 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 743721005254 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 743721005255 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743721005256 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743721005257 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 743721005258 IMP binding site; other site 743721005259 dimer interface [polypeptide binding]; other site 743721005260 interdomain contacts; other site 743721005261 partial ornithine binding site; other site 743721005262 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 743721005263 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 743721005264 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 743721005265 catalytic site [active] 743721005266 subunit interface [polypeptide binding]; other site 743721005267 dihydrodipicolinate reductase; Provisional; Region: PRK00048 743721005268 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 743721005269 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 743721005270 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 743721005271 SlyX; Region: SlyX; cl01090 743721005272 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 743721005273 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 743721005274 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 743721005275 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743721005276 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 743721005277 catalytic residues [active] 743721005278 dimer interface [polypeptide binding]; other site 743721005279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743721005280 DNA-binding site [nucleotide binding]; DNA binding site 743721005281 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743721005282 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 743721005283 Walker A/P-loop; other site 743721005284 ATP binding site [chemical binding]; other site 743721005285 Q-loop/lid; other site 743721005286 ABC transporter signature motif; other site 743721005287 Walker B; other site 743721005288 D-loop; other site 743721005289 H-loop/switch region; other site 743721005290 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 743721005291 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 743721005292 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 743721005293 fumarate hydratase; Reviewed; Region: fumC; PRK00485 743721005294 Class II fumarases; Region: Fumarase_classII; cd01362 743721005295 active site 743721005296 tetramer interface [polypeptide binding]; other site 743721005297 adenylosuccinate lyase; Provisional; Region: PRK09285 743721005298 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 743721005299 tetramer interface [polypeptide binding]; other site 743721005300 active site 743721005301 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 743721005302 Uncharacterized conserved protein [Function unknown]; Region: COG2850 743721005303 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743721005304 Autoinducer synthetase; Region: Autoind_synth; cl17404 743721005305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721005306 Coenzyme A binding pocket [chemical binding]; other site 743721005307 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 743721005308 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 743721005309 TPP-binding site [chemical binding]; other site 743721005310 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 743721005311 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 743721005312 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743721005313 E3 interaction surface; other site 743721005314 lipoyl attachment site [posttranslational modification]; other site 743721005315 e3 binding domain; Region: E3_binding; pfam02817 743721005316 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 743721005317 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 743721005318 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 743721005319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743721005320 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743721005321 Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993 743721005322 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 743721005323 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 743721005324 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 743721005325 NADP binding site [chemical binding]; other site 743721005326 dimer interface [polypeptide binding]; other site 743721005327 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 743721005328 active site 743721005329 catalytic residues [active] 743721005330 Response regulator receiver domain; Region: Response_reg; pfam00072 743721005331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721005332 active site 743721005333 phosphorylation site [posttranslational modification] 743721005334 intermolecular recognition site; other site 743721005335 dimerization interface [polypeptide binding]; other site 743721005336 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743721005337 HSP70 interaction site [polypeptide binding]; other site 743721005338 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 743721005339 substrate binding site [polypeptide binding]; other site 743721005340 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 743721005341 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 743721005342 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 743721005343 putative dimer interface [polypeptide binding]; other site 743721005344 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 743721005345 catalytic triad [active] 743721005346 dimer interface [polypeptide binding]; other site 743721005347 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 743721005348 Transglycosylase; Region: Transgly; pfam00912 743721005349 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 743721005350 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 743721005351 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743721005352 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743721005353 active site 743721005354 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743721005355 putative DNA binding site [nucleotide binding]; other site 743721005356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721005357 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743721005358 S-adenosylmethionine binding site [chemical binding]; other site 743721005359 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 743721005360 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 743721005361 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 743721005362 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 743721005363 substrate binding pocket [chemical binding]; other site 743721005364 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 743721005365 B12 binding site [chemical binding]; other site 743721005366 cobalt ligand [ion binding]; other site 743721005367 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 743721005368 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 743721005369 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 743721005370 NAD binding site [chemical binding]; other site 743721005371 homodimer interface [polypeptide binding]; other site 743721005372 homotetramer interface [polypeptide binding]; other site 743721005373 active site 743721005374 elongation factor P; Provisional; Region: PRK04542 743721005375 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 743721005376 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 743721005377 RNA binding site [nucleotide binding]; other site 743721005378 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 743721005379 RNA binding site [nucleotide binding]; other site 743721005380 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 743721005381 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 743721005382 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743721005383 FAD binding domain; Region: FAD_binding_4; pfam01565 743721005384 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 743721005385 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 743721005386 ligand binding site [chemical binding]; other site 743721005387 NAD binding site [chemical binding]; other site 743721005388 tetramer interface [polypeptide binding]; other site 743721005389 catalytic site [active] 743721005390 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 743721005391 L-serine binding site [chemical binding]; other site 743721005392 ACT domain interface; other site 743721005393 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 743721005394 nudix motif; other site 743721005395 amino acid transporter; Region: 2A0306; TIGR00909 743721005396 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 743721005397 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 743721005398 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 743721005399 intersubunit interface [polypeptide binding]; other site 743721005400 active site 743721005401 Zn2+ binding site [ion binding]; other site 743721005402 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 743721005403 Cupin domain; Region: Cupin_2; cl17218 743721005404 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 743721005405 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 743721005406 Cna protein B-type domain; Region: Cna_B_2; pfam13715 743721005407 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743721005408 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 743721005409 active site 743721005410 metal binding site [ion binding]; metal-binding site 743721005411 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 743721005412 active site 743721005413 metal binding site [ion binding]; metal-binding site 743721005414 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 743721005415 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 743721005416 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 743721005417 metal binding site [ion binding]; metal-binding site 743721005418 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 743721005419 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 743721005420 substrate binding site [chemical binding]; other site 743721005421 glutamase interaction surface [polypeptide binding]; other site 743721005422 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 743721005423 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 743721005424 catalytic residues [active] 743721005425 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 743721005426 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 743721005427 putative active site [active] 743721005428 oxyanion strand; other site 743721005429 catalytic triad [active] 743721005430 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 743721005431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721005432 active site 743721005433 motif I; other site 743721005434 motif II; other site 743721005435 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 743721005436 putative active site pocket [active] 743721005437 4-fold oligomerization interface [polypeptide binding]; other site 743721005438 metal binding residues [ion binding]; metal-binding site 743721005439 3-fold/trimer interface [polypeptide binding]; other site 743721005440 histidinol-phosphate aminotransferase; Provisional; Region: PRK04781 743721005441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743721005442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721005443 homodimer interface [polypeptide binding]; other site 743721005444 catalytic residue [active] 743721005445 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 743721005446 histidinol dehydrogenase; Region: hisD; TIGR00069 743721005447 NAD binding site [chemical binding]; other site 743721005448 dimerization interface [polypeptide binding]; other site 743721005449 product binding site; other site 743721005450 substrate binding site [chemical binding]; other site 743721005451 zinc binding site [ion binding]; other site 743721005452 catalytic residues [active] 743721005453 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 743721005454 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 743721005455 HisG, C-terminal domain; Region: HisG_C; cl06867 743721005456 Trp repressor protein; Region: Trp_repressor; cl17266 743721005457 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 743721005458 active sites [active] 743721005459 tetramer interface [polypeptide binding]; other site 743721005460 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 743721005461 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 743721005462 dimer interface [polypeptide binding]; other site 743721005463 motif 1; other site 743721005464 active site 743721005465 motif 2; other site 743721005466 motif 3; other site 743721005467 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 743721005468 anticodon binding site; other site 743721005469 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743721005470 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743721005471 ligand binding site [chemical binding]; other site 743721005472 flexible hinge region; other site 743721005473 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 743721005474 putative switch regulator; other site 743721005475 non-specific DNA interactions [nucleotide binding]; other site 743721005476 DNA binding site [nucleotide binding] 743721005477 sequence specific DNA binding site [nucleotide binding]; other site 743721005478 putative cAMP binding site [chemical binding]; other site 743721005479 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 743721005480 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 743721005481 RNase E interface [polypeptide binding]; other site 743721005482 trimer interface [polypeptide binding]; other site 743721005483 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 743721005484 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 743721005485 RNase E interface [polypeptide binding]; other site 743721005486 trimer interface [polypeptide binding]; other site 743721005487 active site 743721005488 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 743721005489 putative nucleic acid binding region [nucleotide binding]; other site 743721005490 G-X-X-G motif; other site 743721005491 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 743721005492 RNA binding site [nucleotide binding]; other site 743721005493 domain interface; other site 743721005494 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 743721005495 16S/18S rRNA binding site [nucleotide binding]; other site 743721005496 S13e-L30e interaction site [polypeptide binding]; other site 743721005497 25S rRNA binding site [nucleotide binding]; other site 743721005498 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04642 743721005499 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 743721005500 RNA binding site [nucleotide binding]; other site 743721005501 active site 743721005502 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 743721005503 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 743721005504 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 743721005505 translation initiation factor IF-2; Region: IF-2; TIGR00487 743721005506 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 743721005507 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 743721005508 G1 box; other site 743721005509 putative GEF interaction site [polypeptide binding]; other site 743721005510 GTP/Mg2+ binding site [chemical binding]; other site 743721005511 Switch I region; other site 743721005512 G2 box; other site 743721005513 G3 box; other site 743721005514 Switch II region; other site 743721005515 G4 box; other site 743721005516 G5 box; other site 743721005517 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 743721005518 Translation-initiation factor 2; Region: IF-2; pfam11987 743721005519 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 743721005520 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 743721005521 NusA N-terminal domain; Region: NusA_N; pfam08529 743721005522 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 743721005523 RNA binding site [nucleotide binding]; other site 743721005524 homodimer interface [polypeptide binding]; other site 743721005525 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 743721005526 G-X-X-G motif; other site 743721005527 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 743721005528 G-X-X-G motif; other site 743721005529 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 743721005530 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 743721005531 ribosome maturation protein RimP; Reviewed; Region: PRK00092 743721005532 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 743721005533 putative oligomer interface [polypeptide binding]; other site 743721005534 putative RNA binding site [nucleotide binding]; other site 743721005535 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 743721005536 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743721005537 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 743721005538 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743721005539 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 743721005540 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 743721005541 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743721005542 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 743721005543 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 743721005544 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 743721005545 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 743721005546 4Fe-4S binding domain; Region: Fer4; pfam00037 743721005547 4Fe-4S binding domain; Region: Fer4; pfam00037 743721005548 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 743721005549 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 743721005550 NADH dehydrogenase subunit G; Validated; Region: PRK09129 743721005551 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743721005552 catalytic loop [active] 743721005553 iron binding site [ion binding]; other site 743721005554 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 743721005555 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 743721005556 molybdopterin cofactor binding site; other site 743721005557 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 743721005558 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 743721005559 SLBB domain; Region: SLBB; pfam10531 743721005560 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 743721005561 NADH dehydrogenase subunit E; Validated; Region: PRK07539 743721005562 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 743721005563 putative dimer interface [polypeptide binding]; other site 743721005564 [2Fe-2S] cluster binding site [ion binding]; other site 743721005565 NADH dehydrogenase subunit D; Validated; Region: PRK06075 743721005566 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 743721005567 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 743721005568 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 743721005569 NADH dehydrogenase subunit B; Validated; Region: PRK06411 743721005570 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 743721005571 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 743721005572 triosephosphate isomerase; Provisional; Region: PRK14567 743721005573 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 743721005574 substrate binding site [chemical binding]; other site 743721005575 dimer interface [polypeptide binding]; other site 743721005576 catalytic triad [active] 743721005577 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 743721005578 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 743721005579 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 743721005580 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 743721005581 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 743721005582 active site 743721005583 substrate binding site [chemical binding]; other site 743721005584 metal binding site [ion binding]; metal-binding site 743721005585 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 743721005586 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 743721005587 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743721005588 active site 2 [active] 743721005589 active site 1 [active] 743721005590 Uncharacterized conserved protein [Function unknown]; Region: COG2928 743721005591 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 743721005592 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 743721005593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743721005594 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 743721005595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743721005596 Beta-Casp domain; Region: Beta-Casp; smart01027 743721005597 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 743721005598 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 743721005599 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 743721005600 active site 743721005601 Zn binding site [ion binding]; other site 743721005602 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 743721005603 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 743721005604 active site 743721005605 Zn binding site [ion binding]; other site 743721005606 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 743721005607 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 743721005608 Phosphate transporter family; Region: PHO4; pfam01384 743721005609 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 743721005610 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 743721005611 Domain of unknown function DUF21; Region: DUF21; pfam01595 743721005612 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743721005613 Transporter associated domain; Region: CorC_HlyC; smart01091 743721005614 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 743721005615 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 743721005616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743721005617 dimerization interface [polypeptide binding]; other site 743721005618 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721005619 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721005620 metal binding site [ion binding]; metal-binding site 743721005621 active site 743721005622 I-site; other site 743721005623 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743721005624 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 743721005625 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 743721005626 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 743721005627 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 743721005628 active site 743721005629 dimerization interface [polypeptide binding]; other site 743721005630 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 743721005631 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 743721005632 Protein export membrane protein; Region: SecD_SecF; pfam02355 743721005633 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 743721005634 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 743721005635 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 743721005636 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 743721005637 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 743721005638 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 743721005639 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 743721005640 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 743721005641 TRAM domain; Region: TRAM; pfam01938 743721005642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721005643 S-adenosylmethionine binding site [chemical binding]; other site 743721005644 Response regulator receiver domain; Region: Response_reg; pfam00072 743721005645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721005646 active site 743721005647 phosphorylation site [posttranslational modification] 743721005648 intermolecular recognition site; other site 743721005649 dimerization interface [polypeptide binding]; other site 743721005650 inner membrane protein; Provisional; Region: PRK11715 743721005651 sensory histidine kinase CreC; Provisional; Region: PRK11100 743721005652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721005653 dimer interface [polypeptide binding]; other site 743721005654 phosphorylation site [posttranslational modification] 743721005655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721005656 ATP binding site [chemical binding]; other site 743721005657 Mg2+ binding site [ion binding]; other site 743721005658 G-X-G motif; other site 743721005659 DNA-binding response regulator CreB; Provisional; Region: PRK11083 743721005660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721005661 active site 743721005662 phosphorylation site [posttranslational modification] 743721005663 intermolecular recognition site; other site 743721005664 dimerization interface [polypeptide binding]; other site 743721005665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743721005666 DNA binding site [nucleotide binding] 743721005667 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 743721005668 Cation efflux family; Region: Cation_efflux; pfam01545 743721005669 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743721005670 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743721005671 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 743721005672 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 743721005673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743721005674 ATP binding site [chemical binding]; other site 743721005675 putative Mg++ binding site [ion binding]; other site 743721005676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721005677 nucleotide binding region [chemical binding]; other site 743721005678 ATP-binding site [chemical binding]; other site 743721005679 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 743721005680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743721005681 Zn2+ binding site [ion binding]; other site 743721005682 Mg2+ binding site [ion binding]; other site 743721005683 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 743721005684 PLD-like domain; Region: PLDc_2; pfam13091 743721005685 putative active site [active] 743721005686 catalytic site [active] 743721005687 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 743721005688 PLD-like domain; Region: PLDc_2; pfam13091 743721005689 putative active site [active] 743721005690 catalytic site [active] 743721005691 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743721005692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721005693 Coenzyme A binding pocket [chemical binding]; other site 743721005694 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 743721005695 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 743721005696 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 743721005697 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 743721005698 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721005699 N-terminal plug; other site 743721005700 ligand-binding site [chemical binding]; other site 743721005701 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743721005702 catalytic core [active] 743721005703 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743721005704 Pirin-related protein [General function prediction only]; Region: COG1741 743721005705 Pirin; Region: Pirin; pfam02678 743721005706 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 743721005707 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 743721005708 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 743721005709 Predicted membrane protein [Function unknown]; Region: COG4709 743721005710 Putative sensor; Region: Sensor; pfam13796 743721005711 Predicted transcriptional regulators [Transcription]; Region: COG1695 743721005712 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 743721005713 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 743721005714 active site 743721005715 EamA-like transporter family; Region: EamA; pfam00892 743721005716 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 743721005717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721005718 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 743721005719 dimerization interface [polypeptide binding]; other site 743721005720 substrate binding pocket [chemical binding]; other site 743721005721 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 743721005722 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743721005723 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 743721005724 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 743721005725 Beta-lactamase; Region: Beta-lactamase; pfam00144 743721005726 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 743721005727 Protein of unknown function DUF72; Region: DUF72; pfam01904 743721005728 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 743721005729 EamA-like transporter family; Region: EamA; pfam00892 743721005730 EamA-like transporter family; Region: EamA; pfam00892 743721005731 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743721005732 GAF domain; Region: GAF; pfam01590 743721005733 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721005734 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721005735 metal binding site [ion binding]; metal-binding site 743721005736 active site 743721005737 I-site; other site 743721005738 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 743721005739 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 743721005740 RNA binding surface [nucleotide binding]; other site 743721005741 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 743721005742 probable active site [active] 743721005743 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721005744 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721005745 metal binding site [ion binding]; metal-binding site 743721005746 active site 743721005747 I-site; other site 743721005748 DEAD-like helicases superfamily; Region: DEXDc; smart00487 743721005749 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743721005750 ATP binding site [chemical binding]; other site 743721005751 Mg++ binding site [ion binding]; other site 743721005752 motif III; other site 743721005753 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721005754 nucleotide binding region [chemical binding]; other site 743721005755 ATP-binding site [chemical binding]; other site 743721005756 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 743721005757 putative RNA binding site [nucleotide binding]; other site 743721005758 Predicted periplasmic protein [Function unknown]; Region: COG3904 743721005759 MAPEG family; Region: MAPEG; cl09190 743721005760 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 743721005761 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 743721005762 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 743721005763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721005764 Coenzyme A binding pocket [chemical binding]; other site 743721005765 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 743721005766 integron integrase; Region: integrase_gron; TIGR02249 743721005767 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 743721005768 Int/Topo IB signature motif; other site 743721005769 urocanate hydratase; Provisional; Region: PRK05414 743721005770 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 743721005771 Sulfatase; Region: Sulfatase; cl17466 743721005772 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 743721005773 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 743721005774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743721005775 AlkA N-terminal domain; Region: AlkA_N; pfam06029 743721005776 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 743721005777 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743721005778 minor groove reading motif; other site 743721005779 helix-hairpin-helix signature motif; other site 743721005780 substrate binding pocket [chemical binding]; other site 743721005781 active site 743721005782 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 743721005783 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 743721005784 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 743721005785 DNA binding site [nucleotide binding] 743721005786 active site 743721005787 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 743721005788 substrate binding site [chemical binding]; other site 743721005789 active site 743721005790 catalytic residues [active] 743721005791 heterodimer interface [polypeptide binding]; other site 743721005792 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 743721005793 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 743721005794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721005795 catalytic residue [active] 743721005796 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743721005797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721005798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743721005799 dimerization interface [polypeptide binding]; other site 743721005800 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 743721005801 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 743721005802 putative active site [active] 743721005803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743721005804 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 743721005805 Walker A/P-loop; other site 743721005806 ATP binding site [chemical binding]; other site 743721005807 Q-loop/lid; other site 743721005808 ABC transporter signature motif; other site 743721005809 Walker B; other site 743721005810 D-loop; other site 743721005811 H-loop/switch region; other site 743721005812 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 743721005813 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743721005814 lipoyl-biotinyl attachment site [posttranslational modification]; other site 743721005815 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721005816 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 743721005817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743721005818 non-specific DNA binding site [nucleotide binding]; other site 743721005819 salt bridge; other site 743721005820 sequence-specific DNA binding site [nucleotide binding]; other site 743721005821 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 743721005822 active site 743721005823 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 743721005824 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 743721005825 dimerization interface 3.5A [polypeptide binding]; other site 743721005826 active site 743721005827 FimV N-terminal domain; Region: FimV_core; TIGR03505 743721005828 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 743721005829 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 743721005830 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 743721005831 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 743721005832 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 743721005833 dimerization interface [polypeptide binding]; other site 743721005834 ligand binding site [chemical binding]; other site 743721005835 NADP binding site [chemical binding]; other site 743721005836 catalytic site [active] 743721005837 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 743721005838 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 743721005839 Tetramer interface [polypeptide binding]; other site 743721005840 active site 743721005841 FMN-binding site [chemical binding]; other site 743721005842 HemK family putative methylases; Region: hemK_fam; TIGR00536 743721005843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721005844 S-adenosylmethionine binding site [chemical binding]; other site 743721005845 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 743721005846 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 743721005847 Cu(I) binding site [ion binding]; other site 743721005848 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 743721005849 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743721005850 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743721005851 catalytic residue [active] 743721005852 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743721005853 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 743721005854 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 743721005855 dimer interface [polypeptide binding]; other site 743721005856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743721005857 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 743721005858 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 743721005859 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743721005860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 743721005861 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 743721005862 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 743721005863 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 743721005864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721005865 FeS/SAM binding site; other site 743721005866 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 743721005867 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 743721005868 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 743721005869 trimer interface [polypeptide binding]; other site 743721005870 active site 743721005871 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 743721005872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721005873 TPR motif; other site 743721005874 binding surface 743721005875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721005876 binding surface 743721005877 TPR motif; other site 743721005878 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 743721005879 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721005880 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721005881 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 743721005882 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 743721005883 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721005884 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 743721005885 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 743721005886 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 743721005887 active site 743721005888 HIGH motif; other site 743721005889 KMSKS motif; other site 743721005890 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 743721005891 tRNA binding surface [nucleotide binding]; other site 743721005892 anticodon binding site; other site 743721005893 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 743721005894 putative tRNA-binding site [nucleotide binding]; other site 743721005895 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 743721005896 ferredoxin; Provisional; Region: PRK08764 743721005897 Putative Fe-S cluster; Region: FeS; pfam04060 743721005898 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 743721005899 TraB family; Region: TraB; pfam01963 743721005900 Uncharacterized conserved protein [Function unknown]; Region: COG3358 743721005901 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 743721005902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721005903 ATP binding site [chemical binding]; other site 743721005904 Mg2+ binding site [ion binding]; other site 743721005905 G-X-G motif; other site 743721005906 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 743721005907 ATP binding site [chemical binding]; other site 743721005908 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 743721005909 AMIN domain; Region: AMIN; pfam11741 743721005910 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 743721005911 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 743721005912 active site 743721005913 metal binding site [ion binding]; metal-binding site 743721005914 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 743721005915 Uncharacterized conserved protein [Function unknown]; Region: COG0062 743721005916 putative carbohydrate kinase; Provisional; Region: PRK10565 743721005917 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 743721005918 putative ATP binding site [chemical binding]; other site 743721005919 putative substrate binding site [chemical binding]; other site 743721005920 epoxyqueuosine reductase; Region: TIGR00276 743721005921 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 743721005922 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 743721005923 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 743721005924 generic binding surface II; other site 743721005925 generic binding surface I; other site 743721005926 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 743721005927 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 743721005928 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 743721005929 active site 743721005930 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 743721005931 Predicted amidohydrolase [General function prediction only]; Region: COG0388 743721005932 putative active site [active] 743721005933 catalytic triad [active] 743721005934 putative dimer interface [polypeptide binding]; other site 743721005935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 743721005936 Coenzyme A binding pocket [chemical binding]; other site 743721005937 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 743721005938 Recombination protein O N terminal; Region: RecO_N; pfam11967 743721005939 Recombination protein O C terminal; Region: RecO_C; pfam02565 743721005940 GTPase Era; Reviewed; Region: era; PRK00089 743721005941 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 743721005942 G1 box; other site 743721005943 GTP/Mg2+ binding site [chemical binding]; other site 743721005944 Switch I region; other site 743721005945 G2 box; other site 743721005946 Switch II region; other site 743721005947 G3 box; other site 743721005948 G4 box; other site 743721005949 G5 box; other site 743721005950 KH domain; Region: KH_2; pfam07650 743721005951 ribonuclease III; Reviewed; Region: rnc; PRK00102 743721005952 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 743721005953 dimerization interface [polypeptide binding]; other site 743721005954 active site 743721005955 metal binding site [ion binding]; metal-binding site 743721005956 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 743721005957 dsRNA binding site [nucleotide binding]; other site 743721005958 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 743721005959 signal peptidase I; Provisional; Region: PRK10861 743721005960 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 743721005961 Catalytic site [active] 743721005962 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 743721005963 GTP-binding protein LepA; Provisional; Region: PRK05433 743721005964 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 743721005965 G1 box; other site 743721005966 putative GEF interaction site [polypeptide binding]; other site 743721005967 GTP/Mg2+ binding site [chemical binding]; other site 743721005968 Switch I region; other site 743721005969 G2 box; other site 743721005970 G3 box; other site 743721005971 Switch II region; other site 743721005972 G4 box; other site 743721005973 G5 box; other site 743721005974 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 743721005975 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 743721005976 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 743721005977 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 743721005978 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 743721005979 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743721005980 protein binding site [polypeptide binding]; other site 743721005981 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743721005982 protein binding site [polypeptide binding]; other site 743721005983 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 743721005984 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 743721005985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743721005986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743721005987 DNA binding residues [nucleotide binding] 743721005988 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 743721005989 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743721005990 substrate binding site [chemical binding]; other site 743721005991 oxyanion hole (OAH) forming residues; other site 743721005992 trimer interface [polypeptide binding]; other site 743721005993 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 743721005994 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743721005995 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 743721005996 PilZ domain; Region: PilZ; cl01260 743721005997 DNA polymerase III subunit delta'; Validated; Region: PRK08769 743721005998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 743721005999 Walker A motif; other site 743721006000 ATP binding site [chemical binding]; other site 743721006001 DNA polymerase III subunit delta'; Validated; Region: PRK08485 743721006002 thymidylate kinase; Validated; Region: tmk; PRK00698 743721006003 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 743721006004 TMP-binding site; other site 743721006005 ATP-binding site [chemical binding]; other site 743721006006 YceG-like family; Region: YceG; pfam02618 743721006007 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 743721006008 dimerization interface [polypeptide binding]; other site 743721006009 hypothetical protein; Validated; Region: PRK09070 743721006010 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 743721006011 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 743721006012 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 743721006013 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743721006014 dimer interface [polypeptide binding]; other site 743721006015 active site 743721006016 acyl carrier protein; Provisional; Region: acpP; PRK00982 743721006017 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 743721006018 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 743721006019 NAD(P) binding site [chemical binding]; other site 743721006020 homotetramer interface [polypeptide binding]; other site 743721006021 homodimer interface [polypeptide binding]; other site 743721006022 active site 743721006023 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 743721006024 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 743721006025 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 743721006026 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 743721006027 dimer interface [polypeptide binding]; other site 743721006028 active site 743721006029 CoA binding pocket [chemical binding]; other site 743721006030 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 743721006031 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 743721006032 Maf-like protein; Region: Maf; pfam02545 743721006033 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 743721006034 active site 743721006035 dimer interface [polypeptide binding]; other site 743721006036 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 743721006037 MoxR-like ATPases [General function prediction only]; Region: COG0714 743721006038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721006039 Walker A motif; other site 743721006040 ATP binding site [chemical binding]; other site 743721006041 Walker B motif; other site 743721006042 arginine finger; other site 743721006043 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 743721006044 Protein of unknown function DUF58; Region: DUF58; pfam01882 743721006045 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 743721006046 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 743721006047 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743721006048 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 743721006049 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 743721006050 nucleotide binding site/active site [active] 743721006051 recombination protein RecR; Reviewed; Region: recR; PRK00076 743721006052 RecR protein; Region: RecR; pfam02132 743721006053 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 743721006054 putative active site [active] 743721006055 putative metal-binding site [ion binding]; other site 743721006056 tetramer interface [polypeptide binding]; other site 743721006057 hypothetical protein; Validated; Region: PRK00153 743721006058 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 743721006059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721006060 Walker A motif; other site 743721006061 ATP binding site [chemical binding]; other site 743721006062 Walker B motif; other site 743721006063 arginine finger; other site 743721006064 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 743721006065 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 743721006066 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 743721006067 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 743721006068 MoaE homodimer interface [polypeptide binding]; other site 743721006069 MoaD interaction [polypeptide binding]; other site 743721006070 active site residues [active] 743721006071 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 743721006072 MoaE interaction surface [polypeptide binding]; other site 743721006073 MoeB interaction surface [polypeptide binding]; other site 743721006074 thiocarboxylated glycine; other site 743721006075 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 743721006076 trimer interface [polypeptide binding]; other site 743721006077 dimer interface [polypeptide binding]; other site 743721006078 putative active site [active] 743721006079 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 743721006080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721006081 FeS/SAM binding site; other site 743721006082 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 743721006083 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 743721006084 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 743721006085 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 743721006086 active site 743721006087 ATP binding site [chemical binding]; other site 743721006088 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 743721006089 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 743721006090 putative active site [active] 743721006091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743721006092 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 743721006093 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 743721006094 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 743721006095 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 743721006096 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 743721006097 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 743721006098 PapC N-terminal domain; Region: PapC_N; pfam13954 743721006099 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 743721006100 PapC C-terminal domain; Region: PapC_C; pfam13953 743721006101 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 743721006102 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 743721006103 active site 743721006104 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 743721006105 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 743721006106 active site 743721006107 catalytic site [active] 743721006108 substrate binding site [chemical binding]; other site 743721006109 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 743721006110 active site 743721006111 RNA/DNA hybrid binding site [nucleotide binding]; other site 743721006112 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 743721006113 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743721006114 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743721006115 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743721006116 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 743721006117 periplasmic folding chaperone; Provisional; Region: PRK10788 743721006118 SurA N-terminal domain; Region: SurA_N_3; cl07813 743721006119 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 743721006120 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743721006121 IHF dimer interface [polypeptide binding]; other site 743721006122 IHF - DNA interface [nucleotide binding]; other site 743721006123 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 743721006124 Found in ATP-dependent protease La (LON); Region: LON; smart00464 743721006125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721006126 Walker A motif; other site 743721006127 ATP binding site [chemical binding]; other site 743721006128 Walker B motif; other site 743721006129 arginine finger; other site 743721006130 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 743721006131 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 743721006132 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 743721006133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721006134 Walker A motif; other site 743721006135 ATP binding site [chemical binding]; other site 743721006136 Walker B motif; other site 743721006137 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 743721006138 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 743721006139 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 743721006140 oligomer interface [polypeptide binding]; other site 743721006141 active site residues [active] 743721006142 trigger factor; Provisional; Region: tig; PRK01490 743721006143 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 743721006144 Bax inhibitor 1 like; Region: BaxI_1; cl17691 743721006145 isocitrate dehydrogenase; Provisional; Region: PRK08997 743721006146 tartrate dehydrogenase; Region: TTC; TIGR02089 743721006147 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 743721006148 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 743721006149 GSH binding site [chemical binding]; other site 743721006150 catalytic residues [active] 743721006151 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 743721006152 Peptidase family M48; Region: Peptidase_M48; pfam01435 743721006153 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 743721006154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721006155 active site 743721006156 phosphorylation site [posttranslational modification] 743721006157 intermolecular recognition site; other site 743721006158 dimerization interface [polypeptide binding]; other site 743721006159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743721006160 DNA binding site [nucleotide binding] 743721006161 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 743721006162 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743721006163 PAS domain; Region: PAS_8; pfam13188 743721006164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721006165 dimer interface [polypeptide binding]; other site 743721006166 phosphorylation site [posttranslational modification] 743721006167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721006168 ATP binding site [chemical binding]; other site 743721006169 Mg2+ binding site [ion binding]; other site 743721006170 G-X-G motif; other site 743721006171 polyphosphate kinase; Provisional; Region: PRK05443 743721006172 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 743721006173 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 743721006174 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743721006175 putative active site [active] 743721006176 catalytic site [active] 743721006177 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 743721006178 putative domain interface [polypeptide binding]; other site 743721006179 putative active site [active] 743721006180 catalytic site [active] 743721006181 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 743721006182 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 743721006183 von Willebrand factor; Region: vWF_A; pfam12450 743721006184 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 743721006185 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 743721006186 metal ion-dependent adhesion site (MIDAS); other site 743721006187 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 743721006188 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 743721006189 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 743721006190 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 743721006191 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 743721006192 hypothetical protein; Validated; Region: PRK00228 743721006193 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 743721006194 Protein of unknown function DUF72; Region: DUF72; pfam01904 743721006195 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 743721006196 Uncharacterized conserved protein [Function unknown]; Region: COG1284 743721006197 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 743721006198 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743721006199 Walker A motif; other site 743721006200 ATP binding site [chemical binding]; other site 743721006201 Walker B motif; other site 743721006202 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 743721006203 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 743721006204 Walker A motif; other site 743721006205 ATP binding site [chemical binding]; other site 743721006206 Walker B motif; other site 743721006207 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 743721006208 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743721006209 catalytic residue [active] 743721006210 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 743721006211 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 743721006212 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 743721006213 Pirin-related protein [General function prediction only]; Region: COG1741 743721006214 Pirin; Region: Pirin; pfam02678 743721006215 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 743721006216 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 743721006217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743721006218 dimer interface [polypeptide binding]; other site 743721006219 conserved gate region; other site 743721006220 putative PBP binding loops; other site 743721006221 ABC-ATPase subunit interface; other site 743721006222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743721006223 dimer interface [polypeptide binding]; other site 743721006224 conserved gate region; other site 743721006225 putative PBP binding loops; other site 743721006226 ABC-ATPase subunit interface; other site 743721006227 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 743721006228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721006229 Walker A/P-loop; other site 743721006230 ATP binding site [chemical binding]; other site 743721006231 Q-loop/lid; other site 743721006232 ABC transporter signature motif; other site 743721006233 Walker B; other site 743721006234 D-loop; other site 743721006235 H-loop/switch region; other site 743721006236 TOBE domain; Region: TOBE_2; pfam08402 743721006237 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743721006238 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743721006239 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743721006240 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743721006241 putative aminotransferase; Validated; Region: PRK07480 743721006242 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743721006243 inhibitor-cofactor binding pocket; inhibition site 743721006244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721006245 catalytic residue [active] 743721006246 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743721006247 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 743721006248 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743721006249 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 743721006250 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 743721006251 catalytic triad [active] 743721006252 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743721006253 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743721006254 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743721006255 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743721006256 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743721006257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721006258 active site 743721006259 phosphorylation site [posttranslational modification] 743721006260 intermolecular recognition site; other site 743721006261 dimerization interface [polypeptide binding]; other site 743721006262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721006263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721006264 metal binding site [ion binding]; metal-binding site 743721006265 active site 743721006266 I-site; other site 743721006267 Hemerythrin; Region: Hemerythrin; cd12107 743721006268 Fe binding site [ion binding]; other site 743721006269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721006270 metabolite-proton symporter; Region: 2A0106; TIGR00883 743721006271 putative substrate translocation pore; other site 743721006272 Protein of unknown function (DUF3247); Region: DUF3247; pfam11607 743721006273 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 743721006274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721006275 motif II; other site 743721006276 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 743721006277 putative catalytic site [active] 743721006278 putative phosphate binding site [ion binding]; other site 743721006279 active site 743721006280 metal binding site A [ion binding]; metal-binding site 743721006281 DNA binding site [nucleotide binding] 743721006282 putative AP binding site [nucleotide binding]; other site 743721006283 putative metal binding site B [ion binding]; other site 743721006284 Protein of unknown function DUF72; Region: DUF72; pfam01904 743721006285 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 743721006286 dihydrodipicolinate synthase; Region: dapA; TIGR00674 743721006287 dimer interface [polypeptide binding]; other site 743721006288 active site 743721006289 catalytic residue [active] 743721006290 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 743721006291 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 743721006292 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 743721006293 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 743721006294 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 743721006295 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 743721006296 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743721006297 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 743721006298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721006299 motif II; other site 743721006300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721006301 PAS domain; Region: PAS_9; pfam13426 743721006302 putative active site [active] 743721006303 heme pocket [chemical binding]; other site 743721006304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721006305 PAS domain; Region: PAS_9; pfam13426 743721006306 putative active site [active] 743721006307 heme pocket [chemical binding]; other site 743721006308 GAF domain; Region: GAF; cl17456 743721006309 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743721006310 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721006311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721006312 metal binding site [ion binding]; metal-binding site 743721006313 active site 743721006314 I-site; other site 743721006315 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743721006316 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 743721006317 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 743721006318 NAD(P) binding site [chemical binding]; other site 743721006319 catalytic residues [active] 743721006320 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 743721006321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743721006322 non-specific DNA binding site [nucleotide binding]; other site 743721006323 salt bridge; other site 743721006324 sequence-specific DNA binding site [nucleotide binding]; other site 743721006325 Cupin domain; Region: Cupin_2; pfam07883 743721006326 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 743721006327 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743721006328 inhibitor-cofactor binding pocket; inhibition site 743721006329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721006330 catalytic residue [active] 743721006331 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 743721006332 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 743721006333 hexamer interface [polypeptide binding]; other site 743721006334 ligand binding site [chemical binding]; other site 743721006335 putative active site [active] 743721006336 NAD(P) binding site [chemical binding]; other site 743721006337 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 743721006338 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 743721006339 tetrameric interface [polypeptide binding]; other site 743721006340 NAD binding site [chemical binding]; other site 743721006341 catalytic residues [active] 743721006342 Predicted membrane protein [Function unknown]; Region: COG2733 743721006343 Response regulator receiver domain; Region: Response_reg; pfam00072 743721006344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721006345 active site 743721006346 phosphorylation site [posttranslational modification] 743721006347 intermolecular recognition site; other site 743721006348 dimerization interface [polypeptide binding]; other site 743721006349 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 743721006350 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 743721006351 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 743721006352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743721006353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743721006354 Methyltransferase domain; Region: Methyltransf_26; pfam13659 743721006355 Transposase domain (DUF772); Region: DUF772; pfam05598 743721006356 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 743721006357 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 743721006358 MOSC domain; Region: MOSC; pfam03473 743721006359 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 743721006360 substrate binding site [chemical binding]; other site 743721006361 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 743721006362 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 743721006363 active site 743721006364 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 743721006365 catalytic triad [active] 743721006366 dimer interface [polypeptide binding]; other site 743721006367 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 743721006368 EF-hand domain pair; Region: EF_hand_5; pfam13499 743721006369 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 743721006370 Ca2+ binding site [ion binding]; other site 743721006371 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 743721006372 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 743721006373 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 743721006374 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 743721006375 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 743721006376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721006377 PAS fold; Region: PAS_3; pfam08447 743721006378 putative active site [active] 743721006379 heme pocket [chemical binding]; other site 743721006380 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 743721006381 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 743721006382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721006383 ATP-grasp domain; Region: ATP-grasp; pfam02222 743721006384 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 743721006385 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 743721006386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 743721006387 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 743721006388 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 743721006389 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743721006390 FAD binding domain; Region: FAD_binding_4; pfam01565 743721006391 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 743721006392 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743721006393 endonuclease III; Region: ENDO3c; smart00478 743721006394 minor groove reading motif; other site 743721006395 helix-hairpin-helix signature motif; other site 743721006396 substrate binding pocket [chemical binding]; other site 743721006397 active site 743721006398 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 743721006399 hydrophobic ligand binding site; other site 743721006400 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743721006401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721006402 active site 743721006403 phosphorylation site [posttranslational modification] 743721006404 intermolecular recognition site; other site 743721006405 dimerization interface [polypeptide binding]; other site 743721006406 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743721006407 DNA binding residues [nucleotide binding] 743721006408 dimerization interface [polypeptide binding]; other site 743721006409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 743721006410 Histidine kinase; Region: HisKA_3; pfam07730 743721006411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721006412 ATP binding site [chemical binding]; other site 743721006413 Mg2+ binding site [ion binding]; other site 743721006414 G-X-G motif; other site 743721006415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 743721006416 septum formation inhibitor; Reviewed; Region: minC; PRK04596 743721006417 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 743721006418 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 743721006419 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 743721006420 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 743721006421 Switch I; other site 743721006422 Switch II; other site 743721006423 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 743721006424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743721006425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721006426 dimer interface [polypeptide binding]; other site 743721006427 phosphorylation site [posttranslational modification] 743721006428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721006429 ATP binding site [chemical binding]; other site 743721006430 Mg2+ binding site [ion binding]; other site 743721006431 G-X-G motif; other site 743721006432 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743721006433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721006434 active site 743721006435 phosphorylation site [posttranslational modification] 743721006436 intermolecular recognition site; other site 743721006437 dimerization interface [polypeptide binding]; other site 743721006438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743721006439 DNA binding site [nucleotide binding] 743721006440 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 743721006441 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 743721006442 active site 743721006443 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 743721006444 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 743721006445 Sulfatase; Region: Sulfatase; pfam00884 743721006446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 743721006447 Transposase; Region: DDE_Tnp_ISL3; pfam01610 743721006448 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 743721006449 active site 743721006450 Zn binding site [ion binding]; other site 743721006451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743721006452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721006453 putative substrate translocation pore; other site 743721006454 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 743721006455 glycine dehydrogenase; Provisional; Region: PRK05367 743721006456 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 743721006457 tetramer interface [polypeptide binding]; other site 743721006458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721006459 catalytic residue [active] 743721006460 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 743721006461 tetramer interface [polypeptide binding]; other site 743721006462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721006463 catalytic residue [active] 743721006464 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 743721006465 T5orf172 domain; Region: T5orf172; pfam10544 743721006466 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 743721006467 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 743721006468 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 743721006469 putative active site [active] 743721006470 putative PHP Thumb interface [polypeptide binding]; other site 743721006471 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 743721006472 generic binding surface I; other site 743721006473 generic binding surface II; other site 743721006474 DNA Polymerase Y-family; Region: PolY_like; cd03468 743721006475 active site 743721006476 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 743721006477 DNA binding site [nucleotide binding] 743721006478 Uncharacterized conserved protein [Function unknown]; Region: COG4544 743721006479 LexA repressor; Provisional; Region: PRK12423 743721006480 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 743721006481 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743721006482 Catalytic site [active] 743721006483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 743721006484 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 743721006485 dimerization interface [polypeptide binding]; other site 743721006486 metal binding site [ion binding]; metal-binding site 743721006487 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 743721006488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743721006489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721006490 putative transporter; Provisional; Region: PRK10504 743721006491 putative substrate translocation pore; other site 743721006492 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 743721006493 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 743721006494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721006495 dimer interface [polypeptide binding]; other site 743721006496 phosphorylation site [posttranslational modification] 743721006497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721006498 ATP binding site [chemical binding]; other site 743721006499 Mg2+ binding site [ion binding]; other site 743721006500 G-X-G motif; other site 743721006501 Response regulator receiver domain; Region: Response_reg; pfam00072 743721006502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721006503 active site 743721006504 phosphorylation site [posttranslational modification] 743721006505 intermolecular recognition site; other site 743721006506 dimerization interface [polypeptide binding]; other site 743721006507 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 743721006508 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743721006509 Walker A motif; other site 743721006510 ATP binding site [chemical binding]; other site 743721006511 Walker B motif; other site 743721006512 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 743721006513 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743721006514 Walker A motif; other site 743721006515 ATP binding site [chemical binding]; other site 743721006516 Walker B motif; other site 743721006517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721006518 S-adenosylmethionine binding site [chemical binding]; other site 743721006519 Putative phosphatase (DUF442); Region: DUF442; cl17385 743721006520 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743721006521 catalytic residues [active] 743721006522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 743721006523 Cation efflux family; Region: Cation_efflux; cl00316 743721006524 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 743721006525 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 743721006526 additional DNA contacts [nucleotide binding]; other site 743721006527 mismatch recognition site; other site 743721006528 active site 743721006529 zinc binding site [ion binding]; other site 743721006530 DNA intercalation site [nucleotide binding]; other site 743721006531 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 743721006532 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 743721006533 cofactor binding site; other site 743721006534 DNA binding site [nucleotide binding] 743721006535 substrate interaction site [chemical binding]; other site 743721006536 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 743721006537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721006538 Walker A motif; other site 743721006539 ATP binding site [chemical binding]; other site 743721006540 Family description; Region: UvrD_C_2; pfam13538 743721006541 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 743721006542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 743721006543 ATP-binding site [chemical binding]; other site 743721006544 Nuclease-related domain; Region: NERD; pfam08378 743721006545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 743721006546 AAA domain; Region: AAA_22; pfam13401 743721006547 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 743721006548 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 743721006549 GDP-binding site [chemical binding]; other site 743721006550 ACT binding site; other site 743721006551 IMP binding site; other site 743721006552 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 743721006553 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 743721006554 active site 743721006555 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 743721006556 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 743721006557 elongation factor G; Reviewed; Region: PRK12740 743721006558 G1 box; other site 743721006559 putative GEF interaction site [polypeptide binding]; other site 743721006560 GTP/Mg2+ binding site [chemical binding]; other site 743721006561 Switch I region; other site 743721006562 G2 box; other site 743721006563 G3 box; other site 743721006564 Switch II region; other site 743721006565 G4 box; other site 743721006566 G5 box; other site 743721006567 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 743721006568 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 743721006569 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 743721006570 EamA-like transporter family; Region: EamA; pfam00892 743721006571 EamA-like transporter family; Region: EamA; pfam00892 743721006572 N-formylglutamate amidohydrolase; Region: FGase; cl01522 743721006573 glutathione reductase; Validated; Region: PRK06116 743721006574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743721006575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743721006576 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743721006577 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 743721006578 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 743721006579 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 743721006580 nucleophile elbow; other site 743721006581 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743721006582 Surface antigen; Region: Bac_surface_Ag; pfam01103 743721006583 Predicted membrane protein [Function unknown]; Region: COG2311 743721006584 Protein of unknown function (DUF418); Region: DUF418; cl12135 743721006585 Protein of unknown function (DUF418); Region: DUF418; pfam04235 743721006586 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 743721006587 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 743721006588 putative active site [active] 743721006589 putative PHP Thumb interface [polypeptide binding]; other site 743721006590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743721006591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721006592 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 743721006593 putative effector binding pocket; other site 743721006594 putative dimerization interface [polypeptide binding]; other site 743721006595 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 743721006596 homotrimer interaction site [polypeptide binding]; other site 743721006597 putative active site [active] 743721006598 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 743721006599 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 743721006600 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 743721006601 TilS substrate binding domain; Region: TilS; pfam09179 743721006602 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 743721006603 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 743721006604 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 743721006605 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 743721006606 substrate binding pocket [chemical binding]; other site 743721006607 chain length determination region; other site 743721006608 substrate-Mg2+ binding site; other site 743721006609 catalytic residues [active] 743721006610 aspartate-rich region 1; other site 743721006611 active site lid residues [active] 743721006612 aspartate-rich region 2; other site 743721006613 Tic20-like protein; Region: Tic20; pfam09685 743721006614 peptidase PmbA; Provisional; Region: PRK11040 743721006615 hypothetical protein; Provisional; Region: PRK05255 743721006616 protease TldD; Provisional; Region: tldD; PRK10735 743721006617 TIGR02099 family protein; Region: TIGR02099 743721006618 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 743721006619 ribonuclease G; Provisional; Region: PRK11712 743721006620 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 743721006621 homodimer interface [polypeptide binding]; other site 743721006622 oligonucleotide binding site [chemical binding]; other site 743721006623 Maf-like protein; Region: Maf; pfam02545 743721006624 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 743721006625 active site 743721006626 dimer interface [polypeptide binding]; other site 743721006627 Uncharacterized conserved protein [Function unknown]; Region: COG2968 743721006628 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 743721006629 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 743721006630 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721006631 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721006632 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 743721006633 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743721006634 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 743721006635 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 743721006636 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 743721006637 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 743721006638 active site 743721006639 (T/H)XGH motif; other site 743721006640 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 743721006641 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 743721006642 Lipopolysaccharide-assembly; Region: LptE; cl01125 743721006643 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 743721006644 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 743721006645 HIGH motif; other site 743721006646 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743721006647 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743721006648 active site 743721006649 KMSKS motif; other site 743721006650 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 743721006651 tRNA binding surface [nucleotide binding]; other site 743721006652 Uncharacterized conserved protein [Function unknown]; Region: COG4095 743721006653 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 743721006654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743721006655 non-specific DNA binding site [nucleotide binding]; other site 743721006656 salt bridge; other site 743721006657 sequence-specific DNA binding site [nucleotide binding]; other site 743721006658 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 743721006659 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 743721006660 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 743721006661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721006662 active site 743721006663 phosphorylation site [posttranslational modification] 743721006664 intermolecular recognition site; other site 743721006665 dimerization interface [polypeptide binding]; other site 743721006666 LytTr DNA-binding domain; Region: LytTR; smart00850 743721006667 Histidine kinase; Region: His_kinase; pfam06580 743721006668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721006669 Mg2+ binding site [ion binding]; other site 743721006670 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 743721006671 Beta-lactamase; Region: Beta-lactamase; pfam00144 743721006672 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 743721006673 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 743721006674 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 743721006675 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743721006676 active site 743721006677 imidazolonepropionase; Validated; Region: PRK09356 743721006678 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 743721006679 active site 743721006680 MerC mercury resistance protein; Region: MerC; pfam03203 743721006681 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721006682 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 743721006683 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721006684 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721006685 Transcriptional regulators [Transcription]; Region: MarR; COG1846 743721006686 MarR family; Region: MarR_2; pfam12802 743721006687 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 743721006688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721006689 putative substrate translocation pore; other site 743721006690 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 743721006691 metal binding site 2 [ion binding]; metal-binding site 743721006692 putative DNA binding helix; other site 743721006693 metal binding site 1 [ion binding]; metal-binding site 743721006694 dimer interface [polypeptide binding]; other site 743721006695 structural Zn2+ binding site [ion binding]; other site 743721006696 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 743721006697 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 743721006698 active site 743721006699 HIGH motif; other site 743721006700 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 743721006701 active site 743721006702 KMSKS motif; other site 743721006703 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721006704 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721006705 metal binding site [ion binding]; metal-binding site 743721006706 active site 743721006707 I-site; other site 743721006708 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 743721006709 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743721006710 putative active site [active] 743721006711 putative metal binding site [ion binding]; other site 743721006712 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 743721006713 dinuclear metal binding motif [ion binding]; other site 743721006714 amidophosphoribosyltransferase; Provisional; Region: PRK09246 743721006715 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 743721006716 active site 743721006717 tetramer interface [polypeptide binding]; other site 743721006718 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743721006719 active site 743721006720 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 743721006721 Colicin V production protein; Region: Colicin_V; pfam02674 743721006722 Sporulation related domain; Region: SPOR; pfam05036 743721006723 Sporulation related domain; Region: SPOR; pfam05036 743721006724 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 743721006725 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743721006726 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743721006727 catalytic core [active] 743721006728 Peptidase S46; Region: Peptidase_S46; pfam10459 743721006729 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 743721006730 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 743721006731 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 743721006732 NAD(P) binding site [chemical binding]; other site 743721006733 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 743721006734 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 743721006735 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 743721006736 Walker A/P-loop; other site 743721006737 ATP binding site [chemical binding]; other site 743721006738 Q-loop/lid; other site 743721006739 ABC transporter signature motif; other site 743721006740 Walker B; other site 743721006741 D-loop; other site 743721006742 H-loop/switch region; other site 743721006743 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 743721006744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743721006745 dimer interface [polypeptide binding]; other site 743721006746 conserved gate region; other site 743721006747 putative PBP binding loops; other site 743721006748 ABC-ATPase subunit interface; other site 743721006749 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 743721006750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743721006751 dimer interface [polypeptide binding]; other site 743721006752 conserved gate region; other site 743721006753 putative PBP binding loops; other site 743721006754 ABC-ATPase subunit interface; other site 743721006755 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 743721006756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743721006757 substrate binding pocket [chemical binding]; other site 743721006758 membrane-bound complex binding site; other site 743721006759 hinge residues; other site 743721006760 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 743721006761 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 743721006762 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 743721006763 substrate-cofactor binding pocket; other site 743721006764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721006765 catalytic residue [active] 743721006766 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 743721006767 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743721006768 RNA binding surface [nucleotide binding]; other site 743721006769 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 743721006770 active site 743721006771 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 743721006772 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743721006773 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743721006774 ligand binding site [chemical binding]; other site 743721006775 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 743721006776 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 743721006777 putative NAD(P) binding site [chemical binding]; other site 743721006778 dimer interface [polypeptide binding]; other site 743721006779 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 743721006780 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 743721006781 active site 743721006782 FMN binding site [chemical binding]; other site 743721006783 2,4-decadienoyl-CoA binding site; other site 743721006784 catalytic residue [active] 743721006785 4Fe-4S cluster binding site [ion binding]; other site 743721006786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743721006787 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 743721006788 glutathionine S-transferase; Provisional; Region: PRK10542 743721006789 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 743721006790 C-terminal domain interface [polypeptide binding]; other site 743721006791 GSH binding site (G-site) [chemical binding]; other site 743721006792 dimer interface [polypeptide binding]; other site 743721006793 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 743721006794 dimer interface [polypeptide binding]; other site 743721006795 N-terminal domain interface [polypeptide binding]; other site 743721006796 substrate binding pocket (H-site) [chemical binding]; other site 743721006797 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 743721006798 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 743721006799 dimer interface [polypeptide binding]; other site 743721006800 active site 743721006801 citrylCoA binding site [chemical binding]; other site 743721006802 oxalacetate/citrate binding site [chemical binding]; other site 743721006803 coenzyme A binding site [chemical binding]; other site 743721006804 catalytic triad [active] 743721006805 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 743721006806 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 743721006807 tetramer interface [polypeptide binding]; other site 743721006808 active site 743721006809 Mg2+/Mn2+ binding site [ion binding]; other site 743721006810 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 743721006811 Helix-turn-helix domain; Region: HTH_17; pfam12728 743721006812 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 743721006813 dimer interface [polypeptide binding]; other site 743721006814 active site 743721006815 coenzyme A binding site [chemical binding]; other site 743721006816 citrylCoA binding site [chemical binding]; other site 743721006817 Citrate synthase; Region: Citrate_synt; pfam00285 743721006818 oxalacetate/citrate binding site [chemical binding]; other site 743721006819 catalytic triad [active] 743721006820 Response regulator receiver domain; Region: Response_reg; pfam00072 743721006821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721006822 active site 743721006823 phosphorylation site [posttranslational modification] 743721006824 intermolecular recognition site; other site 743721006825 dimerization interface [polypeptide binding]; other site 743721006826 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743721006827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721006828 dimer interface [polypeptide binding]; other site 743721006829 phosphorylation site [posttranslational modification] 743721006830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721006831 ATP binding site [chemical binding]; other site 743721006832 Mg2+ binding site [ion binding]; other site 743721006833 G-X-G motif; other site 743721006834 Response regulator receiver domain; Region: Response_reg; pfam00072 743721006835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721006836 active site 743721006837 phosphorylation site [posttranslational modification] 743721006838 intermolecular recognition site; other site 743721006839 dimerization interface [polypeptide binding]; other site 743721006840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721006841 dimer interface [polypeptide binding]; other site 743721006842 phosphorylation site [posttranslational modification] 743721006843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721006844 ATP binding site [chemical binding]; other site 743721006845 Mg2+ binding site [ion binding]; other site 743721006846 G-X-G motif; other site 743721006847 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 743721006848 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 743721006849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 743721006850 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 743721006851 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 743721006852 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 743721006853 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 743721006854 substrate binding site [chemical binding]; other site 743721006855 active site 743721006856 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 743721006857 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 743721006858 Cupin domain; Region: Cupin_2; pfam07883 743721006859 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743721006860 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743721006861 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 743721006862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 743721006863 acyl-activating enzyme (AAE) consensus motif; other site 743721006864 AMP binding site [chemical binding]; other site 743721006865 active site 743721006866 CoA binding site [chemical binding]; other site 743721006867 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 743721006868 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721006869 malate dehydrogenase; Provisional; Region: PRK05442 743721006870 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 743721006871 NAD(P) binding site [chemical binding]; other site 743721006872 dimer interface [polypeptide binding]; other site 743721006873 malate binding site [chemical binding]; other site 743721006874 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 743721006875 catalytic residues [active] 743721006876 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 743721006877 active site 743721006878 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 743721006879 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 743721006880 G1 box; other site 743721006881 putative GEF interaction site [polypeptide binding]; other site 743721006882 GTP/Mg2+ binding site [chemical binding]; other site 743721006883 Switch I region; other site 743721006884 G2 box; other site 743721006885 G3 box; other site 743721006886 Switch II region; other site 743721006887 G4 box; other site 743721006888 G5 box; other site 743721006889 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 743721006890 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 743721006891 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743721006892 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743721006893 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 743721006894 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 743721006895 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 743721006896 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 743721006897 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 743721006898 alphaNTD homodimer interface [polypeptide binding]; other site 743721006899 alphaNTD - beta interaction site [polypeptide binding]; other site 743721006900 alphaNTD - beta' interaction site [polypeptide binding]; other site 743721006901 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 743721006902 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 743721006903 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 743721006904 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743721006905 RNA binding surface [nucleotide binding]; other site 743721006906 30S ribosomal protein S11; Validated; Region: PRK05309 743721006907 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 743721006908 30S ribosomal protein S13; Region: bact_S13; TIGR03631 743721006909 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 743721006910 SecY translocase; Region: SecY; pfam00344 743721006911 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 743721006912 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 743721006913 23S rRNA binding site [nucleotide binding]; other site 743721006914 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 743721006915 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 743721006916 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 743721006917 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 743721006918 5S rRNA interface [nucleotide binding]; other site 743721006919 23S rRNA interface [nucleotide binding]; other site 743721006920 L5 interface [polypeptide binding]; other site 743721006921 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 743721006922 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 743721006923 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 743721006924 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 743721006925 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 743721006926 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 743721006927 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 743721006928 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 743721006929 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 743721006930 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 743721006931 RNA binding site [nucleotide binding]; other site 743721006932 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 743721006933 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 743721006934 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 743721006935 putative translocon interaction site; other site 743721006936 23S rRNA interface [nucleotide binding]; other site 743721006937 signal recognition particle (SRP54) interaction site; other site 743721006938 L23 interface [polypeptide binding]; other site 743721006939 trigger factor interaction site; other site 743721006940 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 743721006941 23S rRNA interface [nucleotide binding]; other site 743721006942 5S rRNA interface [nucleotide binding]; other site 743721006943 putative antibiotic binding site [chemical binding]; other site 743721006944 L25 interface [polypeptide binding]; other site 743721006945 L27 interface [polypeptide binding]; other site 743721006946 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 743721006947 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 743721006948 G-X-X-G motif; other site 743721006949 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 743721006950 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 743721006951 putative translocon binding site; other site 743721006952 protein-rRNA interface [nucleotide binding]; other site 743721006953 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 743721006954 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 743721006955 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 743721006956 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 743721006957 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 743721006958 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 743721006959 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 743721006960 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 743721006961 elongation factor Tu; Reviewed; Region: PRK00049 743721006962 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 743721006963 G1 box; other site 743721006964 GEF interaction site [polypeptide binding]; other site 743721006965 GTP/Mg2+ binding site [chemical binding]; other site 743721006966 Switch I region; other site 743721006967 G2 box; other site 743721006968 G3 box; other site 743721006969 Switch II region; other site 743721006970 G4 box; other site 743721006971 G5 box; other site 743721006972 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 743721006973 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 743721006974 Antibiotic Binding Site [chemical binding]; other site 743721006975 elongation factor G; Reviewed; Region: PRK00007 743721006976 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 743721006977 G1 box; other site 743721006978 putative GEF interaction site [polypeptide binding]; other site 743721006979 GTP/Mg2+ binding site [chemical binding]; other site 743721006980 Switch I region; other site 743721006981 G2 box; other site 743721006982 G3 box; other site 743721006983 Switch II region; other site 743721006984 G4 box; other site 743721006985 G5 box; other site 743721006986 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 743721006987 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 743721006988 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 743721006989 30S ribosomal protein S7; Validated; Region: PRK05302 743721006990 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 743721006991 S17 interaction site [polypeptide binding]; other site 743721006992 S8 interaction site; other site 743721006993 16S rRNA interaction site [nucleotide binding]; other site 743721006994 streptomycin interaction site [chemical binding]; other site 743721006995 23S rRNA interaction site [nucleotide binding]; other site 743721006996 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 743721006997 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 743721006998 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 743721006999 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 743721007000 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 743721007001 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 743721007002 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 743721007003 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 743721007004 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 743721007005 DNA binding site [nucleotide binding] 743721007006 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 743721007007 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 743721007008 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 743721007009 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 743721007010 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 743721007011 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 743721007012 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 743721007013 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 743721007014 RPB3 interaction site [polypeptide binding]; other site 743721007015 RPB1 interaction site [polypeptide binding]; other site 743721007016 RPB11 interaction site [polypeptide binding]; other site 743721007017 RPB10 interaction site [polypeptide binding]; other site 743721007018 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 743721007019 core dimer interface [polypeptide binding]; other site 743721007020 peripheral dimer interface [polypeptide binding]; other site 743721007021 L10 interface [polypeptide binding]; other site 743721007022 L11 interface [polypeptide binding]; other site 743721007023 putative EF-Tu interaction site [polypeptide binding]; other site 743721007024 putative EF-G interaction site [polypeptide binding]; other site 743721007025 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 743721007026 23S rRNA interface [nucleotide binding]; other site 743721007027 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 743721007028 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 743721007029 mRNA/rRNA interface [nucleotide binding]; other site 743721007030 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 743721007031 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 743721007032 23S rRNA interface [nucleotide binding]; other site 743721007033 L7/L12 interface [polypeptide binding]; other site 743721007034 putative thiostrepton binding site; other site 743721007035 L25 interface [polypeptide binding]; other site 743721007036 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 743721007037 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 743721007038 putative homodimer interface [polypeptide binding]; other site 743721007039 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 743721007040 heterodimer interface [polypeptide binding]; other site 743721007041 homodimer interface [polypeptide binding]; other site 743721007042 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 743721007043 elongation factor Tu; Reviewed; Region: PRK00049 743721007044 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 743721007045 G1 box; other site 743721007046 GEF interaction site [polypeptide binding]; other site 743721007047 GTP/Mg2+ binding site [chemical binding]; other site 743721007048 Switch I region; other site 743721007049 G2 box; other site 743721007050 G3 box; other site 743721007051 Switch II region; other site 743721007052 G4 box; other site 743721007053 G5 box; other site 743721007054 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 743721007055 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 743721007056 Antibiotic Binding Site [chemical binding]; other site 743721007057 GTP-binding protein YchF; Reviewed; Region: PRK09601 743721007058 YchF GTPase; Region: YchF; cd01900 743721007059 G1 box; other site 743721007060 GTP/Mg2+ binding site [chemical binding]; other site 743721007061 Switch I region; other site 743721007062 G2 box; other site 743721007063 Switch II region; other site 743721007064 G3 box; other site 743721007065 G4 box; other site 743721007066 G5 box; other site 743721007067 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 743721007068 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 743721007069 putative active site [active] 743721007070 catalytic residue [active] 743721007071 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 743721007072 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 743721007073 5S rRNA interface [nucleotide binding]; other site 743721007074 CTC domain interface [polypeptide binding]; other site 743721007075 L16 interface [polypeptide binding]; other site 743721007076 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 743721007077 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 743721007078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743721007079 active site 743721007080 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 743721007081 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 743721007082 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 743721007083 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 743721007084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721007085 TPR motif; other site 743721007086 TPR repeat; Region: TPR_11; pfam13414 743721007087 binding surface 743721007088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721007089 binding surface 743721007090 TPR motif; other site 743721007091 TPR repeat; Region: TPR_11; pfam13414 743721007092 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 743721007093 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 743721007094 tRNA; other site 743721007095 putative tRNA binding site [nucleotide binding]; other site 743721007096 putative NADP binding site [chemical binding]; other site 743721007097 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 743721007098 peptide chain release factor 1; Validated; Region: prfA; PRK00591 743721007099 This domain is found in peptide chain release factors; Region: PCRF; smart00937 743721007100 RF-1 domain; Region: RF-1; pfam00472 743721007101 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 743721007102 MPT binding site; other site 743721007103 trimer interface [polypeptide binding]; other site 743721007104 Acylphosphatase; Region: Acylphosphatase; pfam00708 743721007105 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 743721007106 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743721007107 catalytic residues [active] 743721007108 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 743721007109 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 743721007110 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 743721007111 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743721007112 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 743721007113 active site 743721007114 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 743721007115 putative deacylase active site [active] 743721007116 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 743721007117 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 743721007118 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 743721007119 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 743721007120 RNA polymerase factor sigma-70; Validated; Region: PRK09047 743721007121 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743721007122 DNA binding residues [nucleotide binding] 743721007123 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 743721007124 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 743721007125 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 743721007126 ligand binding site [chemical binding]; other site 743721007127 homodimer interface [polypeptide binding]; other site 743721007128 NAD(P) binding site [chemical binding]; other site 743721007129 trimer interface B [polypeptide binding]; other site 743721007130 trimer interface A [polypeptide binding]; other site 743721007131 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 743721007132 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 743721007133 putative FMN binding site [chemical binding]; other site 743721007134 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 743721007135 active site 743721007136 metal binding site 1 [ion binding]; metal-binding site 743721007137 putative 5' ssDNA interaction site; other site 743721007138 metal binding site 3; metal-binding site 743721007139 metal binding site 2 [ion binding]; metal-binding site 743721007140 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 743721007141 putative DNA binding site [nucleotide binding]; other site 743721007142 putative metal binding site [ion binding]; other site 743721007143 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 743721007144 ADP-ribose binding site [chemical binding]; other site 743721007145 dimer interface [polypeptide binding]; other site 743721007146 active site 743721007147 nudix motif; other site 743721007148 metal binding site [ion binding]; metal-binding site 743721007149 N-formylglutamate amidohydrolase; Region: FGase; cl01522 743721007150 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 743721007151 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 743721007152 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 743721007153 TAP-like protein; Region: Abhydrolase_4; pfam08386 743721007154 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 743721007155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743721007156 peroxiredoxin; Region: AhpC; TIGR03137 743721007157 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 743721007158 dimer interface [polypeptide binding]; other site 743721007159 decamer (pentamer of dimers) interface [polypeptide binding]; other site 743721007160 catalytic triad [active] 743721007161 peroxidatic and resolving cysteines [active] 743721007162 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 743721007163 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 743721007164 catalytic residue [active] 743721007165 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 743721007166 catalytic residues [active] 743721007167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743721007168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743721007169 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 743721007170 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721007171 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 743721007172 dimerization interface [polypeptide binding]; other site 743721007173 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 743721007174 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743721007175 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 743721007176 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 743721007177 active site 743721007178 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 743721007179 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 743721007180 dimer interface [polypeptide binding]; other site 743721007181 active site 743721007182 ADP-ribose binding site [chemical binding]; other site 743721007183 nudix motif; other site 743721007184 metal binding site [ion binding]; metal-binding site 743721007185 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK08742 743721007186 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743721007187 inhibitor-cofactor binding pocket; inhibition site 743721007188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721007189 catalytic residue [active] 743721007190 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 743721007191 RNA methyltransferase, RsmE family; Region: TIGR00046 743721007192 CheW-like domain; Region: CheW; pfam01584 743721007193 CheB methylesterase; Region: CheB_methylest; pfam01339 743721007194 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743721007195 putative binding surface; other site 743721007196 active site 743721007197 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743721007198 putative binding surface; other site 743721007199 active site 743721007200 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 743721007201 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 743721007202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721007203 ATP binding site [chemical binding]; other site 743721007204 Mg2+ binding site [ion binding]; other site 743721007205 G-X-G motif; other site 743721007206 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 743721007207 Response regulator receiver domain; Region: Response_reg; pfam00072 743721007208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721007209 active site 743721007210 phosphorylation site [posttranslational modification] 743721007211 intermolecular recognition site; other site 743721007212 dimerization interface [polypeptide binding]; other site 743721007213 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 743721007214 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743721007215 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743721007216 dimer interface [polypeptide binding]; other site 743721007217 putative CheW interface [polypeptide binding]; other site 743721007218 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 743721007219 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743721007220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721007221 active site 743721007222 phosphorylation site [posttranslational modification] 743721007223 intermolecular recognition site; other site 743721007224 dimerization interface [polypeptide binding]; other site 743721007225 Response regulator receiver domain; Region: Response_reg; pfam00072 743721007226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721007227 active site 743721007228 phosphorylation site [posttranslational modification] 743721007229 intermolecular recognition site; other site 743721007230 dimerization interface [polypeptide binding]; other site 743721007231 glutathione synthetase; Provisional; Region: PRK05246 743721007232 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 743721007233 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 743721007234 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 743721007235 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743721007236 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 743721007237 active site 743721007238 intersubunit interface [polypeptide binding]; other site 743721007239 catalytic residue [active] 743721007240 pyruvate kinase; Provisional; Region: PRK05826 743721007241 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 743721007242 domain interfaces; other site 743721007243 active site 743721007244 transaldolase-like protein; Provisional; Region: PTZ00411 743721007245 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 743721007246 active site 743721007247 dimer interface [polypeptide binding]; other site 743721007248 catalytic residue [active] 743721007249 methionine sulfoxide reductase A; Provisional; Region: PRK00058 743721007250 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 743721007251 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 743721007252 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743721007253 active site 743721007254 HIGH motif; other site 743721007255 nucleotide binding site [chemical binding]; other site 743721007256 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743721007257 active site 743721007258 KMSKS motif; other site 743721007259 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 743721007260 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 743721007261 nucleoside/Zn binding site; other site 743721007262 dimer interface [polypeptide binding]; other site 743721007263 catalytic motif [active] 743721007264 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 743721007265 FtsJ-like methyltransferase; Region: FtsJ; cl17430 743721007266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721007267 binding surface 743721007268 TPR motif; other site 743721007269 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 743721007270 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 743721007271 endo-1,4-D-glucanase; Provisional; Region: PRK11097 743721007272 cellulose synthase regulator protein; Provisional; Region: PRK11114 743721007273 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 743721007274 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743721007275 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 743721007276 DXD motif; other site 743721007277 PilZ domain; Region: PilZ; pfam07238 743721007278 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 743721007279 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 743721007280 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 743721007281 active site 743721007282 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 743721007283 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 743721007284 Probable Catalytic site; other site 743721007285 metal-binding site 743721007286 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 743721007287 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 743721007288 dimerization interface [polypeptide binding]; other site 743721007289 ATP binding site [chemical binding]; other site 743721007290 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 743721007291 dimerization interface [polypeptide binding]; other site 743721007292 ATP binding site [chemical binding]; other site 743721007293 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 743721007294 putative active site [active] 743721007295 catalytic triad [active] 743721007296 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 743721007297 dimerization domain [polypeptide binding]; other site 743721007298 dimer interface [polypeptide binding]; other site 743721007299 catalytic residues [active] 743721007300 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 743721007301 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743721007302 active site 743721007303 DNA binding site [nucleotide binding] 743721007304 Int/Topo IB signature motif; other site 743721007305 RDD family; Region: RDD; pfam06271 743721007306 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 743721007307 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 743721007308 Predicted permeases [General function prediction only]; Region: COG0795 743721007309 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 743721007310 multifunctional aminopeptidase A; Provisional; Region: PRK00913 743721007311 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 743721007312 interface (dimer of trimers) [polypeptide binding]; other site 743721007313 Substrate-binding/catalytic site; other site 743721007314 Zn-binding sites [ion binding]; other site 743721007315 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 743721007316 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 743721007317 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743721007318 active site 743721007319 HIGH motif; other site 743721007320 nucleotide binding site [chemical binding]; other site 743721007321 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743721007322 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 743721007323 active site 743721007324 KMSKS motif; other site 743721007325 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 743721007326 tRNA binding surface [nucleotide binding]; other site 743721007327 anticodon binding site; other site 743721007328 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 743721007329 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 743721007330 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743721007331 Coenzyme A binding pocket [chemical binding]; other site 743721007332 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 743721007333 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 743721007334 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743721007335 prolyl-tRNA synthetase; Provisional; Region: PRK09194 743721007336 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 743721007337 dimer interface [polypeptide binding]; other site 743721007338 motif 1; other site 743721007339 active site 743721007340 motif 2; other site 743721007341 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 743721007342 putative deacylase active site [active] 743721007343 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 743721007344 active site 743721007345 motif 3; other site 743721007346 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 743721007347 anticodon binding site; other site 743721007348 H-NS histone family; Region: Histone_HNS; pfam00816 743721007349 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 743721007350 Uncharacterized conserved protein [Function unknown]; Region: COG2966 743721007351 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 743721007352 Uncharacterized conserved protein [Function unknown]; Region: COG3610 743721007353 STAS domain; Region: STAS_2; pfam13466 743721007354 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 743721007355 Permease; Region: Permease; pfam02405 743721007356 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 743721007357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721007358 Walker A/P-loop; other site 743721007359 ATP binding site [chemical binding]; other site 743721007360 Q-loop/lid; other site 743721007361 ABC transporter signature motif; other site 743721007362 Walker B; other site 743721007363 D-loop; other site 743721007364 H-loop/switch region; other site 743721007365 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 743721007366 mce related protein; Region: MCE; pfam02470 743721007367 Protein of unknown function (DUF330); Region: DUF330; cl01135 743721007368 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 743721007369 hydroxyglutarate oxidase; Provisional; Region: PRK11728 743721007370 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 743721007371 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 743721007372 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 743721007373 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 743721007374 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 743721007375 phosphomannomutase CpsG; Provisional; Region: PRK15414 743721007376 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 743721007377 active site 743721007378 substrate binding site [chemical binding]; other site 743721007379 metal binding site [ion binding]; metal-binding site 743721007380 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 743721007381 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 743721007382 Substrate binding site; other site 743721007383 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 743721007384 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 743721007385 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 743721007386 NADP binding site [chemical binding]; other site 743721007387 active site 743721007388 putative substrate binding site [chemical binding]; other site 743721007389 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 743721007390 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 743721007391 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 743721007392 substrate binding site; other site 743721007393 tetramer interface; other site 743721007394 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 743721007395 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 743721007396 NAD binding site [chemical binding]; other site 743721007397 substrate binding site [chemical binding]; other site 743721007398 homodimer interface [polypeptide binding]; other site 743721007399 active site 743721007400 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 743721007401 Ligand binding site [chemical binding]; other site 743721007402 Electron transfer flavoprotein domain; Region: ETF; pfam01012 743721007403 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 743721007404 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 743721007405 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 743721007406 Methyltransferase domain; Region: Methyltransf_23; pfam13489 743721007407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721007408 S-adenosylmethionine binding site [chemical binding]; other site 743721007409 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 743721007410 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 743721007411 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 743721007412 Walker A/P-loop; other site 743721007413 ATP binding site [chemical binding]; other site 743721007414 Q-loop/lid; other site 743721007415 ABC transporter signature motif; other site 743721007416 Walker B; other site 743721007417 D-loop; other site 743721007418 H-loop/switch region; other site 743721007419 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 743721007420 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 743721007421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743721007422 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743721007423 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 743721007424 Probable Catalytic site; other site 743721007425 metal-binding site 743721007426 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743721007427 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743721007428 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 743721007429 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 743721007430 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 743721007431 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 743721007432 homodimer interface [polypeptide binding]; other site 743721007433 substrate-cofactor binding pocket; other site 743721007434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721007435 catalytic residue [active] 743721007436 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 743721007437 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 743721007438 dimer interface [polypeptide binding]; other site 743721007439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721007440 catalytic residue [active] 743721007441 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 743721007442 Protein of unknown function (DUF465); Region: DUF465; pfam04325 743721007443 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 743721007444 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743721007445 Walker A motif; other site 743721007446 ATP binding site [chemical binding]; other site 743721007447 Walker B motif; other site 743721007448 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 743721007449 maleylacetoacetate isomerase; Region: maiA; TIGR01262 743721007450 C-terminal domain interface [polypeptide binding]; other site 743721007451 GSH binding site (G-site) [chemical binding]; other site 743721007452 putative dimer interface [polypeptide binding]; other site 743721007453 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 743721007454 dimer interface [polypeptide binding]; other site 743721007455 N-terminal domain interface [polypeptide binding]; other site 743721007456 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 743721007457 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743721007458 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743721007459 DEAD-like helicases superfamily; Region: DEXDc; smart00487 743721007460 ATP binding site [chemical binding]; other site 743721007461 Mg++ binding site [ion binding]; other site 743721007462 motif III; other site 743721007463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721007464 nucleotide binding region [chemical binding]; other site 743721007465 ATP-binding site [chemical binding]; other site 743721007466 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 743721007467 active site 743721007468 Phasin protein; Region: Phasin_2; cl11491 743721007469 AAA domain; Region: AAA_26; pfam13500 743721007470 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 743721007471 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 743721007472 GAF domain; Region: GAF_2; pfam13185 743721007473 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 743721007474 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721007475 N-terminal plug; other site 743721007476 ligand-binding site [chemical binding]; other site 743721007477 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 743721007478 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 743721007479 active site 743721007480 DNA polymerase IV; Validated; Region: PRK02406 743721007481 DNA binding site [nucleotide binding] 743721007482 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 743721007483 active site 1 [active] 743721007484 dimer interface [polypeptide binding]; other site 743721007485 active site 2 [active] 743721007486 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 743721007487 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743721007488 dimer interface [polypeptide binding]; other site 743721007489 active site 743721007490 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743721007491 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743721007492 Amidohydrolase; Region: Amidohydro_4; pfam13147 743721007493 active site 743721007494 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 743721007495 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 743721007496 active site 743721007497 Zn binding site [ion binding]; other site 743721007498 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 743721007499 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 743721007500 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743721007501 catalytic residue [active] 743721007502 P-loop containing region of AAA domain; Region: AAA_29; cl17516 743721007503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 743721007504 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 743721007505 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 743721007506 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 743721007507 THF binding site; other site 743721007508 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 743721007509 substrate binding site [chemical binding]; other site 743721007510 THF binding site; other site 743721007511 zinc-binding site [ion binding]; other site 743721007512 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 743721007513 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 743721007514 glutaminase active site [active] 743721007515 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 743721007516 dimer interface [polypeptide binding]; other site 743721007517 active site 743721007518 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 743721007519 dimer interface [polypeptide binding]; other site 743721007520 active site 743721007521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743721007522 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743721007523 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721007524 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743721007525 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743721007526 Walker A/P-loop; other site 743721007527 ATP binding site [chemical binding]; other site 743721007528 Q-loop/lid; other site 743721007529 ABC transporter signature motif; other site 743721007530 Walker B; other site 743721007531 D-loop; other site 743721007532 H-loop/switch region; other site 743721007533 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743721007534 FtsX-like permease family; Region: FtsX; pfam02687 743721007535 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743721007536 FtsX-like permease family; Region: FtsX; pfam02687 743721007537 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743721007538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721007539 active site 743721007540 phosphorylation site [posttranslational modification] 743721007541 intermolecular recognition site; other site 743721007542 dimerization interface [polypeptide binding]; other site 743721007543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721007544 Walker A motif; other site 743721007545 ATP binding site [chemical binding]; other site 743721007546 Walker B motif; other site 743721007547 arginine finger; other site 743721007548 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743721007549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743721007550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721007551 ATP binding site [chemical binding]; other site 743721007552 Mg2+ binding site [ion binding]; other site 743721007553 G-X-G motif; other site 743721007554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743721007555 Coenzyme A binding pocket [chemical binding]; other site 743721007556 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 743721007557 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 743721007558 Substrate binding site; other site 743721007559 Mg++ binding site; other site 743721007560 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 743721007561 active site 743721007562 substrate binding site [chemical binding]; other site 743721007563 CoA binding site [chemical binding]; other site 743721007564 GtrA-like protein; Region: GtrA; pfam04138 743721007565 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 743721007566 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 743721007567 glutamine binding [chemical binding]; other site 743721007568 catalytic triad [active] 743721007569 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 743721007570 anthranilate synthase component I; Provisional; Region: PRK13565 743721007571 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 743721007572 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 743721007573 lipid kinase; Reviewed; Region: PRK13054 743721007574 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 743721007575 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 743721007576 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 743721007577 substrate binding site [chemical binding]; other site 743721007578 hexamer interface [polypeptide binding]; other site 743721007579 metal binding site [ion binding]; metal-binding site 743721007580 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743721007581 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 743721007582 ATP binding site [chemical binding]; other site 743721007583 active site 743721007584 substrate binding site [chemical binding]; other site 743721007585 Protein of unknown function (DUF962); Region: DUF962; cl01879 743721007586 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 743721007587 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743721007588 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 743721007589 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 743721007590 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 743721007591 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 743721007592 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743721007593 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 743721007594 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 743721007595 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 743721007596 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 743721007597 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 743721007598 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 743721007599 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 743721007600 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 743721007601 dimer interface [polypeptide binding]; other site 743721007602 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 743721007603 active site 743721007604 Fe binding site [ion binding]; other site 743721007605 Transcriptional regulators [Transcription]; Region: MarR; COG1846 743721007606 MarR family; Region: MarR_2; pfam12802 743721007607 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743721007608 POT family; Region: PTR2; cl17359 743721007609 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 743721007610 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 743721007611 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 743721007612 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 743721007613 TPP-binding site [chemical binding]; other site 743721007614 tetramer interface [polypeptide binding]; other site 743721007615 heterodimer interface [polypeptide binding]; other site 743721007616 phosphorylation loop region [posttranslational modification] 743721007617 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 743721007618 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 743721007619 alpha subunit interface [polypeptide binding]; other site 743721007620 TPP binding site [chemical binding]; other site 743721007621 heterodimer interface [polypeptide binding]; other site 743721007622 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743721007623 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 743721007624 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743721007625 E3 interaction surface; other site 743721007626 lipoyl attachment site [posttranslational modification]; other site 743721007627 e3 binding domain; Region: E3_binding; pfam02817 743721007628 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 743721007629 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 743721007630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743721007631 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 743721007632 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 743721007633 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 743721007634 active site 743721007635 HIGH motif; other site 743721007636 dimer interface [polypeptide binding]; other site 743721007637 KMSKS motif; other site 743721007638 CsbD-like; Region: CsbD; cl17424 743721007639 Predicted small secreted protein [Function unknown]; Region: COG5510 743721007640 Arginase family; Region: Arginase; cd09989 743721007641 agmatinase; Region: agmatinase; TIGR01230 743721007642 active site 743721007643 Mn binding site [ion binding]; other site 743721007644 oligomer interface [polypeptide binding]; other site 743721007645 Sporulation related domain; Region: SPOR; pfam05036 743721007646 Sporulation related domain; Region: SPOR; cl10051 743721007647 Type III pantothenate kinase; Region: Pan_kinase; cl17198 743721007648 Biotin operon repressor [Transcription]; Region: BirA; COG1654 743721007649 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 743721007650 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 743721007651 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 743721007652 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 743721007653 Transposase domain (DUF772); Region: DUF772; pfam05598 743721007654 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 743721007655 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 743721007656 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 743721007657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721007658 dimer interface [polypeptide binding]; other site 743721007659 phosphorylation site [posttranslational modification] 743721007660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721007661 ATP binding site [chemical binding]; other site 743721007662 Mg2+ binding site [ion binding]; other site 743721007663 G-X-G motif; other site 743721007664 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743721007665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721007666 active site 743721007667 phosphorylation site [posttranslational modification] 743721007668 intermolecular recognition site; other site 743721007669 dimerization interface [polypeptide binding]; other site 743721007670 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743721007671 DNA binding site [nucleotide binding] 743721007672 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 743721007673 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 743721007674 FMN binding site [chemical binding]; other site 743721007675 active site 743721007676 catalytic residues [active] 743721007677 substrate binding site [chemical binding]; other site 743721007678 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721007679 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743721007680 N-terminal plug; other site 743721007681 ligand-binding site [chemical binding]; other site 743721007682 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 743721007683 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 743721007684 active site 743721007685 dimer interface [polypeptide binding]; other site 743721007686 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 743721007687 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743721007688 catalytic residues [active] 743721007689 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 743721007690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721007691 motif II; other site 743721007692 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 743721007693 EF-hand domain pair; Region: EF_hand_5; pfam13499 743721007694 Ca2+ binding site [ion binding]; other site 743721007695 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 743721007696 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 743721007697 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 743721007698 Beta-lactamase; Region: Beta-lactamase; pfam00144 743721007699 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 743721007700 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 743721007701 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721007702 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721007703 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 743721007704 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743721007705 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 743721007706 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 743721007707 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 743721007708 NlpC/P60 family; Region: NLPC_P60; cl17555 743721007709 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 743721007710 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 743721007711 active site 743721007712 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 743721007713 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 743721007714 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 743721007715 putative active site [active] 743721007716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 743721007717 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 743721007718 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 743721007719 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 743721007720 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 743721007721 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 743721007722 BON domain; Region: BON; pfam04972 743721007723 putative oxidoreductase; Provisional; Region: PRK11579 743721007724 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 743721007725 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 743721007726 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 743721007727 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 743721007728 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721007729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721007730 metal binding site [ion binding]; metal-binding site 743721007731 active site 743721007732 I-site; other site 743721007733 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 743721007734 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 743721007735 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743721007736 EF-hand domain pair; Region: EF_hand_5; pfam13499 743721007737 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 743721007738 Ca2+ binding site [ion binding]; other site 743721007739 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 743721007740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743721007741 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 743721007742 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 743721007743 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 743721007744 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 743721007745 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 743721007746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721007747 FeS/SAM binding site; other site 743721007748 Kelch motif; Region: Kelch_6; pfam13964 743721007749 Kelch motif; Region: Kelch_1; pfam01344 743721007750 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 743721007751 Kelch motif; Region: Kelch_6; pfam13964 743721007752 Kelch domain; Region: Kelch; smart00612 743721007753 Kelch motif; Region: Kelch_1; pfam01344 743721007754 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 743721007755 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 743721007756 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743721007757 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721007758 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 743721007759 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 743721007760 Putative esterase; Region: Esterase; pfam00756 743721007761 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 743721007762 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743721007763 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743721007764 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 743721007765 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721007766 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 743721007767 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 743721007768 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 743721007769 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 743721007770 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 743721007771 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 743721007772 Transposase, Mutator family; Region: Transposase_mut; pfam00872 743721007773 MULE transposase domain; Region: MULE; pfam10551 743721007774 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 743721007775 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 743721007776 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743721007777 RNA binding surface [nucleotide binding]; other site 743721007778 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 743721007779 active site 743721007780 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 743721007781 ATP binding site [chemical binding]; other site 743721007782 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 743721007783 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 743721007784 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 743721007785 TSCPD domain; Region: TSCPD; pfam12637 743721007786 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 743721007787 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 743721007788 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 743721007789 active site 743721007790 dimer interface [polypeptide binding]; other site 743721007791 effector binding site; other site 743721007792 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 743721007793 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 743721007794 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 743721007795 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743721007796 protein binding site [polypeptide binding]; other site 743721007797 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743721007798 protein binding site [polypeptide binding]; other site 743721007799 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 743721007800 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 743721007801 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 743721007802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721007803 motif II; other site 743721007804 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 743721007805 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 743721007806 interface (dimer of trimers) [polypeptide binding]; other site 743721007807 Substrate-binding/catalytic site; other site 743721007808 Zn-binding sites [ion binding]; other site 743721007809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743721007810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721007811 active site 743721007812 phosphorylation site [posttranslational modification] 743721007813 intermolecular recognition site; other site 743721007814 dimerization interface [polypeptide binding]; other site 743721007815 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743721007816 DNA binding residues [nucleotide binding] 743721007817 dimerization interface [polypeptide binding]; other site 743721007818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 743721007819 Histidine kinase; Region: HisKA_3; pfam07730 743721007820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721007821 ATP binding site [chemical binding]; other site 743721007822 Mg2+ binding site [ion binding]; other site 743721007823 G-X-G motif; other site 743721007824 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743721007825 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743721007826 HlyD family secretion protein; Region: HlyD_3; pfam13437 743721007827 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743721007828 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743721007829 Walker A/P-loop; other site 743721007830 ATP binding site [chemical binding]; other site 743721007831 Q-loop/lid; other site 743721007832 ABC transporter signature motif; other site 743721007833 Walker B; other site 743721007834 D-loop; other site 743721007835 H-loop/switch region; other site 743721007836 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743721007837 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 743721007838 FtsX-like permease family; Region: FtsX; pfam02687 743721007839 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 743721007840 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743721007841 FtsX-like permease family; Region: FtsX; pfam02687 743721007842 adenylate kinase; Reviewed; Region: adk; PRK00279 743721007843 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 743721007844 AMP-binding site [chemical binding]; other site 743721007845 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 743721007846 6-phosphofructokinase; Provisional; Region: PRK14072 743721007847 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 743721007848 active site 743721007849 ADP/pyrophosphate binding site [chemical binding]; other site 743721007850 allosteric effector site; other site 743721007851 dimerization interface [polypeptide binding]; other site 743721007852 fructose-1,6-bisphosphate binding site; other site 743721007853 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 743721007854 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 743721007855 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 743721007856 proline aminopeptidase P II; Provisional; Region: PRK10879 743721007857 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 743721007858 active site 743721007859 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 743721007860 TIGR02449 family protein; Region: TIGR02449 743721007861 Cell division protein ZapA; Region: ZapA; pfam05164 743721007862 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 743721007863 Uncharacterized conserved protein [Function unknown]; Region: COG2947 743721007864 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 743721007865 tetramer (dimer of dimers) interface [polypeptide binding]; other site 743721007866 active site 743721007867 dimer interface [polypeptide binding]; other site 743721007868 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 743721007869 Uncharacterized conserved protein [Function unknown]; Region: COG2912 743721007870 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 743721007871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743721007872 binding surface 743721007873 TPR motif; other site 743721007874 Rubredoxin [Energy production and conversion]; Region: COG1773 743721007875 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 743721007876 iron binding site [ion binding]; other site 743721007877 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 743721007878 thiamine phosphate binding site [chemical binding]; other site 743721007879 active site 743721007880 pyrophosphate binding site [ion binding]; other site 743721007881 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 743721007882 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743721007883 inhibitor-cofactor binding pocket; inhibition site 743721007884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721007885 catalytic residue [active] 743721007886 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 743721007887 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 743721007888 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 743721007889 HIT family signature motif; other site 743721007890 catalytic residue [active] 743721007891 acetylornithine transaminase protein; Provisional; Region: argD; PRK04612 743721007892 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743721007893 inhibitor-cofactor binding pocket; inhibition site 743721007894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721007895 catalytic residue [active] 743721007896 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 743721007897 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 743721007898 homodimer interface [polypeptide binding]; other site 743721007899 substrate-cofactor binding pocket; other site 743721007900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721007901 catalytic residue [active] 743721007902 Integral membrane protein TerC family; Region: TerC; cl10468 743721007903 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 743721007904 dimer interface [polypeptide binding]; other site 743721007905 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743721007906 active site 743721007907 metal binding site [ion binding]; metal-binding site 743721007908 glutathione binding site [chemical binding]; other site 743721007909 short chain dehydrogenase; Provisional; Region: PRK08278 743721007910 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 743721007911 NAD(P) binding site [chemical binding]; other site 743721007912 homodimer interface [polypeptide binding]; other site 743721007913 active site 743721007914 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 743721007915 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 743721007916 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 743721007917 active site 743721007918 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 743721007919 LssY C-terminus; Region: LssY_C; pfam14067 743721007920 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 743721007921 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 743721007922 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743721007923 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 743721007924 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743721007925 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743721007926 Predicted permeases [General function prediction only]; Region: RarD; COG2962 743721007927 EamA-like transporter family; Region: EamA; pfam00892 743721007928 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 743721007929 EamA-like transporter family; Region: EamA; pfam00892 743721007930 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 743721007931 Protein required for attachment to host cells; Region: Host_attach; pfam10116 743721007932 methionine sulfoxide reductase B; Provisional; Region: PRK00222 743721007933 SelR domain; Region: SelR; pfam01641 743721007934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 743721007935 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 743721007936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721007937 active site 743721007938 phosphorylation site [posttranslational modification] 743721007939 intermolecular recognition site; other site 743721007940 dimerization interface [polypeptide binding]; other site 743721007941 LytTr DNA-binding domain; Region: LytTR; smart00850 743721007942 Histidine kinase; Region: His_kinase; pfam06580 743721007943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 743721007944 ATP binding site [chemical binding]; other site 743721007945 Mg2+ binding site [ion binding]; other site 743721007946 G-X-G motif; other site 743721007947 HI0933-like protein; Region: HI0933_like; pfam03486 743721007948 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743721007949 YaeQ protein; Region: YaeQ; pfam07152 743721007950 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 743721007951 PAS fold; Region: PAS_4; pfam08448 743721007952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721007953 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 743721007954 putative active site [active] 743721007955 heme pocket [chemical binding]; other site 743721007956 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743721007957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721007958 putative active site [active] 743721007959 heme pocket [chemical binding]; other site 743721007960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721007961 dimer interface [polypeptide binding]; other site 743721007962 phosphorylation site [posttranslational modification] 743721007963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721007964 ATP binding site [chemical binding]; other site 743721007965 Mg2+ binding site [ion binding]; other site 743721007966 G-X-G motif; other site 743721007967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721007968 Response regulator receiver domain; Region: Response_reg; pfam00072 743721007969 active site 743721007970 phosphorylation site [posttranslational modification] 743721007971 intermolecular recognition site; other site 743721007972 dimerization interface [polypeptide binding]; other site 743721007973 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 743721007974 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 743721007975 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 743721007976 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 743721007977 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 743721007978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721007979 putative substrate translocation pore; other site 743721007980 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 743721007981 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_2; cd08974 743721007982 putative DNA binding site [nucleotide binding]; other site 743721007983 catalytic residue [active] 743721007984 putative H2TH interface [polypeptide binding]; other site 743721007985 putative catalytic residues [active] 743721007986 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 743721007987 Protein of unknown function, DUF479; Region: DUF479; cl01203 743721007988 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 743721007989 Trehalase; Region: Trehalase; cl17346 743721007990 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743721007991 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 743721007992 C-terminal domain interface [polypeptide binding]; other site 743721007993 GSH binding site (G-site) [chemical binding]; other site 743721007994 dimer interface [polypeptide binding]; other site 743721007995 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 743721007996 N-terminal domain interface [polypeptide binding]; other site 743721007997 dimer interface [polypeptide binding]; other site 743721007998 substrate binding pocket (H-site) [chemical binding]; other site 743721007999 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 743721008000 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 743721008001 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 743721008002 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721008003 CHASE domain; Region: CHASE; pfam03924 743721008004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721008005 PAS domain; Region: PAS_9; pfam13426 743721008006 putative active site [active] 743721008007 heme pocket [chemical binding]; other site 743721008008 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721008009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721008010 metal binding site [ion binding]; metal-binding site 743721008011 active site 743721008012 I-site; other site 743721008013 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743721008014 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 743721008015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721008016 S-adenosylmethionine binding site [chemical binding]; other site 743721008017 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 743721008018 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743721008019 Ligand Binding Site [chemical binding]; other site 743721008020 FOG: CBS domain [General function prediction only]; Region: COG0517 743721008021 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 743721008022 cardiolipin synthase 2; Provisional; Region: PRK11263 743721008023 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 743721008024 putative active site [active] 743721008025 catalytic site [active] 743721008026 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 743721008027 putative active site [active] 743721008028 catalytic site [active] 743721008029 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 743721008030 putative catalytic site [active] 743721008031 putative metal binding site [ion binding]; other site 743721008032 putative phosphate binding site [ion binding]; other site 743721008033 C factor cell-cell signaling protein; Provisional; Region: PRK09009 743721008034 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 743721008035 NADP binding site [chemical binding]; other site 743721008036 homodimer interface [polypeptide binding]; other site 743721008037 active site 743721008038 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 743721008039 active site triad [active] 743721008040 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 743721008041 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 743721008042 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743721008043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721008044 metal binding site [ion binding]; metal-binding site 743721008045 active site 743721008046 I-site; other site 743721008047 Tannase and feruloyl esterase; Region: Tannase; pfam07519 743721008048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743721008049 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 743721008050 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743721008051 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 743721008052 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743721008053 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 743721008054 C-terminal domain interface [polypeptide binding]; other site 743721008055 GSH binding site (G-site) [chemical binding]; other site 743721008056 dimer interface [polypeptide binding]; other site 743721008057 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743721008058 N-terminal domain interface [polypeptide binding]; other site 743721008059 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 743721008060 Transposase IS200 like; Region: Y1_Tnp; pfam01797 743721008061 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 743721008062 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 743721008063 dimer interface [polypeptide binding]; other site 743721008064 TPP-binding site [chemical binding]; other site 743721008065 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743721008066 anti sigma factor interaction site; other site 743721008067 regulatory phosphorylation site [posttranslational modification]; other site 743721008068 CAAX protease self-immunity; Region: Abi; pfam02517 743721008069 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 743721008070 Malic enzyme, N-terminal domain; Region: malic; pfam00390 743721008071 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 743721008072 putative NAD(P) binding site [chemical binding]; other site 743721008073 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 743721008074 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 743721008075 Predicted GTPases [General function prediction only]; Region: COG1162 743721008076 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 743721008077 GTPase/Zn-binding domain interface [polypeptide binding]; other site 743721008078 GTP/Mg2+ binding site [chemical binding]; other site 743721008079 G4 box; other site 743721008080 G5 box; other site 743721008081 G1 box; other site 743721008082 Switch I region; other site 743721008083 G2 box; other site 743721008084 G3 box; other site 743721008085 Switch II region; other site 743721008086 aminotransferase AlaT; Validated; Region: PRK09265 743721008087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743721008088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721008089 homodimer interface [polypeptide binding]; other site 743721008090 catalytic residue [active] 743721008091 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 743721008092 active site 743721008093 catalytic triad [active] 743721008094 oxyanion hole [active] 743721008095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721008096 S-adenosylmethionine binding site [chemical binding]; other site 743721008097 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 743721008098 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 743721008099 NodB motif; other site 743721008100 active site 743721008101 catalytic site [active] 743721008102 metal binding site [ion binding]; metal-binding site 743721008103 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 743721008104 putative GSH binding site [chemical binding]; other site 743721008105 catalytic residues [active] 743721008106 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 743721008107 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 743721008108 active site residue [active] 743721008109 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 743721008110 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 743721008111 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 743721008112 putative catalytic residue [active] 743721008113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 743721008114 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 743721008115 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 743721008116 Ligand Binding Site [chemical binding]; other site 743721008117 S-formylglutathione hydrolase; Region: PLN02442 743721008118 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 743721008119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721008120 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 743721008121 NAD(P) binding site [chemical binding]; other site 743721008122 active site 743721008123 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 743721008124 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 743721008125 substrate binding site [chemical binding]; other site 743721008126 catalytic Zn binding site [ion binding]; other site 743721008127 NAD binding site [chemical binding]; other site 743721008128 structural Zn binding site [ion binding]; other site 743721008129 dimer interface [polypeptide binding]; other site 743721008130 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 743721008131 putative metal binding site [ion binding]; other site 743721008132 putative homodimer interface [polypeptide binding]; other site 743721008133 putative homotetramer interface [polypeptide binding]; other site 743721008134 putative homodimer-homodimer interface [polypeptide binding]; other site 743721008135 putative allosteric switch controlling residues; other site 743721008136 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 743721008137 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 743721008138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743721008139 Zn2+ binding site [ion binding]; other site 743721008140 Mg2+ binding site [ion binding]; other site 743721008141 glutamate--cysteine ligase; Region: PLN02611 743721008142 CCC1-related family of proteins; Region: CCC1_like; cl00278 743721008143 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 743721008144 G1 box; other site 743721008145 GTP/Mg2+ binding site [chemical binding]; other site 743721008146 Switch I region; other site 743721008147 G2 box; other site 743721008148 G3 box; other site 743721008149 Switch II region; other site 743721008150 G4 box; other site 743721008151 G5 box; other site 743721008152 Cytochrome c553 [Energy production and conversion]; Region: COG2863 743721008153 Cytochrome c; Region: Cytochrom_C; cl11414 743721008154 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 743721008155 catalytic residues [active] 743721008156 hinge region; other site 743721008157 alpha helical domain; other site 743721008158 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 743721008159 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 743721008160 catalytic residues [active] 743721008161 hinge region; other site 743721008162 alpha helical domain; other site 743721008163 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 743721008164 putative catalytic site [active] 743721008165 putative metal binding site [ion binding]; other site 743721008166 putative phosphate binding site [ion binding]; other site 743721008167 tropinone reductase; Provisional; Region: PRK09242 743721008168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721008169 NAD(P) binding site [chemical binding]; other site 743721008170 active site 743721008171 protease 4; Provisional; Region: PRK10949 743721008172 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 743721008173 tandem repeat interface [polypeptide binding]; other site 743721008174 oligomer interface [polypeptide binding]; other site 743721008175 active site residues [active] 743721008176 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 743721008177 tandem repeat interface [polypeptide binding]; other site 743721008178 oligomer interface [polypeptide binding]; other site 743721008179 active site residues [active] 743721008180 multidrug efflux protein; Reviewed; Region: PRK01766 743721008181 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 743721008182 cation binding site [ion binding]; other site 743721008183 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 743721008184 primosome assembly protein PriA; Validated; Region: PRK05580 743721008185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743721008186 ATP binding site [chemical binding]; other site 743721008187 putative Mg++ binding site [ion binding]; other site 743721008188 helicase superfamily c-terminal domain; Region: HELICc; smart00490 743721008189 ATP-binding site [chemical binding]; other site 743721008190 Uncharacterized conserved protein [Function unknown]; Region: COG1432 743721008191 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 743721008192 putative metal binding site [ion binding]; other site 743721008193 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 743721008194 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 743721008195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721008196 putative substrate translocation pore; other site 743721008197 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 743721008198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743721008199 Predicted membrane protein [Function unknown]; Region: COG2860 743721008200 UPF0126 domain; Region: UPF0126; pfam03458 743721008201 UPF0126 domain; Region: UPF0126; pfam03458 743721008202 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 743721008203 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743721008204 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743721008205 DNA binding residues [nucleotide binding] 743721008206 Pirin-related protein [General function prediction only]; Region: COG1741 743721008207 Pirin; Region: Pirin; pfam02678 743721008208 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 743721008209 ligand binding site [chemical binding]; other site 743721008210 active site 743721008211 UGI interface [polypeptide binding]; other site 743721008212 catalytic site [active] 743721008213 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743721008214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721008215 active site 743721008216 phosphorylation site [posttranslational modification] 743721008217 intermolecular recognition site; other site 743721008218 dimerization interface [polypeptide binding]; other site 743721008219 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743721008220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721008221 active site 743721008222 phosphorylation site [posttranslational modification] 743721008223 intermolecular recognition site; other site 743721008224 dimerization interface [polypeptide binding]; other site 743721008225 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 743721008226 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 743721008227 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 743721008228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721008229 Walker A/P-loop; other site 743721008230 ATP binding site [chemical binding]; other site 743721008231 Q-loop/lid; other site 743721008232 ABC transporter signature motif; other site 743721008233 Walker B; other site 743721008234 D-loop; other site 743721008235 H-loop/switch region; other site 743721008236 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 743721008237 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743721008238 ATP binding site [chemical binding]; other site 743721008239 Mg++ binding site [ion binding]; other site 743721008240 motif III; other site 743721008241 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721008242 nucleotide binding region [chemical binding]; other site 743721008243 ATP-binding site [chemical binding]; other site 743721008244 Protein of unknown function (DUF3628); Region: DUF3628; pfam12300 743721008245 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743721008246 catalytic residues [active] 743721008247 transcription termination factor Rho; Provisional; Region: rho; PRK09376 743721008248 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 743721008249 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 743721008250 RNA binding site [nucleotide binding]; other site 743721008251 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 743721008252 multimer interface [polypeptide binding]; other site 743721008253 Walker A motif; other site 743721008254 ATP binding site [chemical binding]; other site 743721008255 Walker B motif; other site 743721008256 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 743721008257 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 743721008258 TrkA-N domain; Region: TrkA_N; pfam02254 743721008259 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 743721008260 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 743721008261 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 743721008262 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 743721008263 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 743721008264 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 743721008265 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 743721008266 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 743721008267 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 743721008268 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 743721008269 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 743721008270 YcgL domain; Region: YcgL; cl01189 743721008271 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 743721008272 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743721008273 dimer interface [polypeptide binding]; other site 743721008274 active site 743721008275 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 743721008276 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 743721008277 Ligand binding site; other site 743721008278 Putative Catalytic site; other site 743721008279 DXD motif; other site 743721008280 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 743721008281 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 743721008282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721008283 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743721008284 NAD(P) binding site [chemical binding]; other site 743721008285 active site 743721008286 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743721008287 active site 2 [active] 743721008288 active site 1 [active] 743721008289 Predicted exporter [General function prediction only]; Region: COG4258 743721008290 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743721008291 putative acyl-acceptor binding pocket; other site 743721008292 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743721008293 Phosphopantetheine attachment site; Region: PP-binding; cl09936 743721008294 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 743721008295 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 743721008296 homotrimer interaction site [polypeptide binding]; other site 743721008297 putative active site [active] 743721008298 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 743721008299 Beta-lactamase; Region: Beta-lactamase; pfam00144 743721008300 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 743721008301 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 743721008302 nucleophile elbow; other site 743721008303 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 743721008304 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 743721008305 acyl-activating enzyme (AAE) consensus motif; other site 743721008306 active site 743721008307 AMP binding site [chemical binding]; other site 743721008308 CoA binding site [chemical binding]; other site 743721008309 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 743721008310 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721008311 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 743721008312 nudix motif; other site 743721008313 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 743721008314 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 743721008315 DNA polymerase I; Provisional; Region: PRK05755 743721008316 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 743721008317 active site 743721008318 metal binding site 1 [ion binding]; metal-binding site 743721008319 putative 5' ssDNA interaction site; other site 743721008320 metal binding site 3; metal-binding site 743721008321 metal binding site 2 [ion binding]; metal-binding site 743721008322 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 743721008323 putative DNA binding site [nucleotide binding]; other site 743721008324 putative metal binding site [ion binding]; other site 743721008325 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 743721008326 active site 743721008327 catalytic site [active] 743721008328 substrate binding site [chemical binding]; other site 743721008329 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 743721008330 active site 743721008331 DNA binding site [nucleotide binding] 743721008332 catalytic site [active] 743721008333 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 743721008334 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 743721008335 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 743721008336 DNA binding residues [nucleotide binding] 743721008337 dimer interface [polypeptide binding]; other site 743721008338 [2Fe-2S] cluster binding site [ion binding]; other site 743721008339 Predicted flavoprotein [General function prediction only]; Region: COG0431 743721008340 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743721008341 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 743721008342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743721008343 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 743721008344 Walker A/P-loop; other site 743721008345 ATP binding site [chemical binding]; other site 743721008346 Q-loop/lid; other site 743721008347 ABC transporter signature motif; other site 743721008348 Walker B; other site 743721008349 D-loop; other site 743721008350 H-loop/switch region; other site 743721008351 TLC ATP/ADP transporter; Region: TLC; cl03940 743721008352 TLC ATP/ADP transporter; Region: TLC; cl03940 743721008353 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743721008354 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743721008355 active site 743721008356 catalytic tetrad [active] 743721008357 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 743721008358 active site 743721008359 DNA binding site [nucleotide binding] 743721008360 Predicted membrane protein [Function unknown]; Region: COG1971 743721008361 Domain of unknown function DUF; Region: DUF204; pfam02659 743721008362 Domain of unknown function DUF; Region: DUF204; pfam02659 743721008363 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743721008364 Ligand Binding Site [chemical binding]; other site 743721008365 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 743721008366 Part of AAA domain; Region: AAA_19; pfam13245 743721008367 Family description; Region: UvrD_C_2; pfam13538 743721008368 hypothetical protein; Provisional; Region: PRK05208 743721008369 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 743721008370 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 743721008371 C-terminal domain interface [polypeptide binding]; other site 743721008372 GSH binding site (G-site) [chemical binding]; other site 743721008373 dimer interface [polypeptide binding]; other site 743721008374 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743721008375 N-terminal domain interface [polypeptide binding]; other site 743721008376 dimer interface [polypeptide binding]; other site 743721008377 substrate binding pocket (H-site) [chemical binding]; other site 743721008378 Integrase core domain; Region: rve; pfam00665 743721008379 Integrase core domain; Region: rve_3; pfam13683 743721008380 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 743721008381 active site 743721008382 catalytic residues [active] 743721008383 metal binding site [ion binding]; metal-binding site 743721008384 Predicted membrane protein [Function unknown]; Region: COG4270 743721008385 aminoglycoside resistance protein; Provisional; Region: PRK13746 743721008386 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 743721008387 active site 743721008388 NTP binding site [chemical binding]; other site 743721008389 metal binding triad [ion binding]; metal-binding site 743721008390 antibiotic binding site [chemical binding]; other site 743721008391 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 743721008392 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 743721008393 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743721008394 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 743721008395 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 743721008396 dimer interface [polypeptide binding]; other site 743721008397 allosteric magnesium binding site [ion binding]; other site 743721008398 active site 743721008399 aspartate-rich active site metal binding site; other site 743721008400 Schiff base residues; other site 743721008401 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743721008402 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743721008403 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 743721008404 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 743721008405 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 743721008406 NAD(P) binding site [chemical binding]; other site 743721008407 shikimate binding site; other site 743721008408 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 743721008409 Protein of unknown function DUF58; Region: DUF58; pfam01882 743721008410 MoxR-like ATPases [General function prediction only]; Region: COG0714 743721008411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 743721008412 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 743721008413 Integral membrane protein DUF95; Region: DUF95; pfam01944 743721008414 RDD family; Region: RDD; pfam06271 743721008415 Flagellin N-methylase; Region: FliB; cl00497 743721008416 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 743721008417 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 743721008418 trimer interface [polypeptide binding]; other site 743721008419 putative metal binding site [ion binding]; other site 743721008420 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 743721008421 NAD(P) binding site [chemical binding]; other site 743721008422 catalytic residues [active] 743721008423 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 743721008424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721008425 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 743721008426 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 743721008427 dimer interface [polypeptide binding]; other site 743721008428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721008429 catalytic residue [active] 743721008430 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 743721008431 putative catalytic site [active] 743721008432 putative phosphate binding site [ion binding]; other site 743721008433 active site 743721008434 metal binding site A [ion binding]; metal-binding site 743721008435 DNA binding site [nucleotide binding] 743721008436 putative AP binding site [nucleotide binding]; other site 743721008437 putative metal binding site B [ion binding]; other site 743721008438 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 743721008439 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 743721008440 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 743721008441 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743721008442 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743721008443 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743721008444 Magnesium ion binding site [ion binding]; other site 743721008445 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 743721008446 ParB-like nuclease domain; Region: ParBc; pfam02195 743721008447 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743721008448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721008449 NAD(P) binding site [chemical binding]; other site 743721008450 active site 743721008451 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 743721008452 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 743721008453 Ligand binding site; other site 743721008454 Putative Catalytic site; other site 743721008455 DXD motif; other site 743721008456 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 743721008457 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 743721008458 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 743721008459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 743721008460 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 743721008461 AAA domain; Region: AAA_33; pfam13671 743721008462 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 743721008463 ATP-binding site [chemical binding]; other site 743721008464 Gluconate-6-phosphate binding site [chemical binding]; other site 743721008465 Glycoside hydrolase family 94 N-terminal-like domain of NdvB-like proteins; Region: GH94N_NdvB_like; cd11748 743721008466 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 743721008467 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 743721008468 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 743721008469 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 743721008470 Na binding site [ion binding]; other site 743721008471 PAS fold; Region: PAS_7; pfam12860 743721008472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721008473 putative active site [active] 743721008474 heme pocket [chemical binding]; other site 743721008475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743721008476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721008477 dimer interface [polypeptide binding]; other site 743721008478 phosphorylation site [posttranslational modification] 743721008479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721008480 ATP binding site [chemical binding]; other site 743721008481 Mg2+ binding site [ion binding]; other site 743721008482 G-X-G motif; other site 743721008483 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743721008484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 743721008485 active site 743721008486 phosphorylation site [posttranslational modification] 743721008487 intermolecular recognition site; other site 743721008488 dimerization interface [polypeptide binding]; other site 743721008489 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 743721008490 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 743721008491 Multicopper oxidase; Region: Cu-oxidase; pfam00394 743721008492 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 743721008493 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 743721008494 short chain dehydrogenase; Provisional; Region: PRK06701 743721008495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721008496 NAD(P) binding site [chemical binding]; other site 743721008497 active site 743721008498 short chain dehydrogenase; Provisional; Region: PRK06181 743721008499 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 743721008500 putative NAD(P) binding site [chemical binding]; other site 743721008501 active site 743721008502 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 743721008503 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 743721008504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721008505 NAD(P) binding site [chemical binding]; other site 743721008506 active site 743721008507 DoxX-like family; Region: DoxX_3; pfam13781 743721008508 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743721008509 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743721008510 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 743721008511 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 743721008512 iron-sulfur cluster [ion binding]; other site 743721008513 [2Fe-2S] cluster binding site [ion binding]; other site 743721008514 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743721008515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721008516 active site 743721008517 phosphorylation site [posttranslational modification] 743721008518 intermolecular recognition site; other site 743721008519 dimerization interface [polypeptide binding]; other site 743721008520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 743721008521 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743721008522 Isochorismatase family; Region: Isochorismatase; pfam00857 743721008523 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 743721008524 catalytic triad [active] 743721008525 conserved cis-peptide bond; other site 743721008526 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 743721008527 dimanganese center [ion binding]; other site 743721008528 Domain of unknown function (DUF892); Region: DUF892; pfam05974 743721008529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743721008530 PAS domain; Region: PAS_9; pfam13426 743721008531 putative active site [active] 743721008532 heme pocket [chemical binding]; other site 743721008533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 743721008534 HWE histidine kinase; Region: HWE_HK; pfam07536 743721008535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721008536 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743721008537 active site 743721008538 phosphorylation site [posttranslational modification] 743721008539 intermolecular recognition site; other site 743721008540 dimerization interface [polypeptide binding]; other site 743721008541 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 743721008542 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 743721008543 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 743721008544 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 743721008545 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743721008546 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 743721008547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743721008548 DNA binding residues [nucleotide binding] 743721008549 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 743721008550 putative active site [active] 743721008551 dimerization interface [polypeptide binding]; other site 743721008552 putative tRNAtyr binding site [nucleotide binding]; other site 743721008553 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 743721008554 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743721008555 putative acyl-acceptor binding pocket; other site 743721008556 Bacterial PH domain; Region: DUF304; pfam03703 743721008557 Predicted membrane protein [Function unknown]; Region: COG3428 743721008558 Bacterial PH domain; Region: DUF304; pfam03703 743721008559 Bacterial PH domain; Region: DUF304; pfam03703 743721008560 Bacterial PH domain; Region: DUF304; pfam03703 743721008561 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 743721008562 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 743721008563 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 743721008564 putative metal binding site; other site 743721008565 EF-hand domain pair; Region: EF_hand_5; pfam13499 743721008566 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 743721008567 Ca2+ binding site [ion binding]; other site 743721008568 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 743721008569 Ca2+ binding site [ion binding]; other site 743721008570 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 743721008571 Fatty acid desaturase; Region: FA_desaturase; pfam00487 743721008572 Di-iron ligands [ion binding]; other site 743721008573 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 743721008574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721008575 Walker A/P-loop; other site 743721008576 ATP binding site [chemical binding]; other site 743721008577 Q-loop/lid; other site 743721008578 ABC transporter signature motif; other site 743721008579 Walker B; other site 743721008580 D-loop; other site 743721008581 H-loop/switch region; other site 743721008582 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 743721008583 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 743721008584 DNA binding site [nucleotide binding] 743721008585 catalytic residue [active] 743721008586 H2TH interface [polypeptide binding]; other site 743721008587 putative catalytic residues [active] 743721008588 turnover-facilitating residue; other site 743721008589 intercalation triad [nucleotide binding]; other site 743721008590 8OG recognition residue [nucleotide binding]; other site 743721008591 putative reading head residues; other site 743721008592 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 743721008593 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 743721008594 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 743721008595 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 743721008596 Response regulator receiver domain; Region: Response_reg; pfam00072 743721008597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721008598 active site 743721008599 phosphorylation site [posttranslational modification] 743721008600 intermolecular recognition site; other site 743721008601 dimerization interface [polypeptide binding]; other site 743721008602 GAF domain; Region: GAF_3; pfam13492 743721008603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721008604 dimer interface [polypeptide binding]; other site 743721008605 phosphorylation site [posttranslational modification] 743721008606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721008607 ATP binding site [chemical binding]; other site 743721008608 Mg2+ binding site [ion binding]; other site 743721008609 G-X-G motif; other site 743721008610 Response regulator receiver domain; Region: Response_reg; pfam00072 743721008611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721008612 active site 743721008613 phosphorylation site [posttranslational modification] 743721008614 intermolecular recognition site; other site 743721008615 dimerization interface [polypeptide binding]; other site 743721008616 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743721008617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721008618 active site 743721008619 phosphorylation site [posttranslational modification] 743721008620 intermolecular recognition site; other site 743721008621 dimerization interface [polypeptide binding]; other site 743721008622 Response regulator receiver domain; Region: Response_reg; pfam00072 743721008623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721008624 active site 743721008625 phosphorylation site [posttranslational modification] 743721008626 intermolecular recognition site; other site 743721008627 dimerization interface [polypeptide binding]; other site 743721008628 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 743721008629 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 743721008630 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 743721008631 CheB methylesterase; Region: CheB_methylest; pfam01339 743721008632 Response regulator receiver domain; Region: Response_reg; pfam00072 743721008633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743721008634 active site 743721008635 phosphorylation site [posttranslational modification] 743721008636 intermolecular recognition site; other site 743721008637 dimerization interface [polypeptide binding]; other site 743721008638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743721008639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743721008640 dimer interface [polypeptide binding]; other site 743721008641 phosphorylation site [posttranslational modification] 743721008642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721008643 ATP binding site [chemical binding]; other site 743721008644 Mg2+ binding site [ion binding]; other site 743721008645 G-X-G motif; other site 743721008646 thymidine kinase; Provisional; Region: PRK04296 743721008647 Sel1 repeat; Region: Sel1; cl02723 743721008648 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 743721008649 Part of AAA domain; Region: AAA_19; pfam13245 743721008650 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 743721008651 Family description; Region: UvrD_C_2; pfam13538 743721008652 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 743721008653 active site 743721008654 catalytic residues [active] 743721008655 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 743721008656 substrate binding site [chemical binding]; other site 743721008657 active site 743721008658 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 743721008659 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 743721008660 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 743721008661 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721008662 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721008663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721008664 D-galactonate transporter; Region: 2A0114; TIGR00893 743721008665 putative substrate translocation pore; other site 743721008666 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 743721008667 glucuronate isomerase; Reviewed; Region: PRK02925 743721008668 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 743721008669 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 743721008670 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 743721008671 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 743721008672 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 743721008673 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 743721008674 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 743721008675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743721008676 ATP binding site [chemical binding]; other site 743721008677 putative Mg++ binding site [ion binding]; other site 743721008678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721008679 nucleotide binding region [chemical binding]; other site 743721008680 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 743721008681 RNase_H superfamily; Region: RNase_H_2; pfam13482 743721008682 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 743721008683 GntP family permease; Region: GntP_permease; pfam02447 743721008684 fructuronate transporter; Provisional; Region: PRK10034; cl15264 743721008685 putative dehydratase; Provisional; Region: PRK08211 743721008686 Dehydratase family; Region: ILVD_EDD; cl00340 743721008687 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 743721008688 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 743721008689 dimer interface [polypeptide binding]; other site 743721008690 NADP binding site [chemical binding]; other site 743721008691 catalytic residues [active] 743721008692 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743721008693 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 743721008694 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 743721008695 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 743721008696 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 743721008697 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 743721008698 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 743721008699 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 743721008700 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 743721008701 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 743721008702 inhibitor binding site; inhibition site 743721008703 active site 743721008704 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 743721008705 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 743721008706 putative active site pocket [active] 743721008707 putative metal binding site [ion binding]; other site 743721008708 Domain of unknown function (DUF303); Region: DUF303; pfam03629 743721008709 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 743721008710 Domain of unknown function (DUF303); Region: DUF303; pfam03629 743721008711 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 743721008712 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 743721008713 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 743721008714 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743721008715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743721008716 DNA binding site [nucleotide binding] 743721008717 domain linker motif; other site 743721008718 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 743721008719 putative dimerization interface [polypeptide binding]; other site 743721008720 putative ligand binding site [chemical binding]; other site 743721008721 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 743721008722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721008723 putative substrate translocation pore; other site 743721008724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721008725 xylose isomerase; Provisional; Region: PRK05474 743721008726 xylose isomerase; Region: xylose_isom_A; TIGR02630 743721008727 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 743721008728 N- and C-terminal domain interface [polypeptide binding]; other site 743721008729 active site 743721008730 MgATP binding site [chemical binding]; other site 743721008731 catalytic site [active] 743721008732 metal binding site [ion binding]; metal-binding site 743721008733 xylulose binding site [chemical binding]; other site 743721008734 putative homodimer interface [polypeptide binding]; other site 743721008735 DinB family; Region: DinB; cl17821 743721008736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743721008737 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 743721008738 active site 743721008739 motif I; other site 743721008740 motif II; other site 743721008741 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 743721008742 active site 743721008743 dimer interface [polypeptide binding]; other site 743721008744 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 743721008745 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 743721008746 putative acyl-acceptor binding pocket; other site 743721008747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 743721008748 DNA binding site [nucleotide binding] 743721008749 Catalytic domain of Protein Kinases; Region: PKc; cd00180 743721008750 active site 743721008751 ATP binding site [chemical binding]; other site 743721008752 substrate binding site [chemical binding]; other site 743721008753 activation loop (A-loop); other site 743721008754 Tetratricopeptide repeat; Region: TPR_12; pfam13424 743721008755 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 743721008756 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 743721008757 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 743721008758 Ligand Binding Site [chemical binding]; other site 743721008759 recombination associated protein; Reviewed; Region: rdgC; PRK00321 743721008760 Protein of unknown function DUF45; Region: DUF45; pfam01863 743721008761 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 743721008762 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 743721008763 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 743721008764 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 743721008765 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 743721008766 C-terminal peptidase (prc); Region: prc; TIGR00225 743721008767 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 743721008768 protein binding site [polypeptide binding]; other site 743721008769 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 743721008770 Catalytic dyad [active] 743721008771 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 743721008772 Peptidase family M23; Region: Peptidase_M23; pfam01551 743721008773 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 743721008774 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 743721008775 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 743721008776 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 743721008777 PA/protease or protease-like domain interface [polypeptide binding]; other site 743721008778 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 743721008779 metal binding site [ion binding]; metal-binding site 743721008780 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 743721008781 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 743721008782 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 743721008783 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 743721008784 ferrochelatase; Reviewed; Region: hemH; PRK00035 743721008785 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 743721008786 C-terminal domain interface [polypeptide binding]; other site 743721008787 active site 743721008788 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 743721008789 active site 743721008790 N-terminal domain interface [polypeptide binding]; other site 743721008791 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 743721008792 putative amphipathic alpha helix; other site 743721008793 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 743721008794 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 743721008795 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 743721008796 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 743721008797 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 743721008798 catalytic triad [active] 743721008799 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 743721008800 dimer interface [polypeptide binding]; other site 743721008801 motif 1; other site 743721008802 active site 743721008803 motif 2; other site 743721008804 motif 3; other site 743721008805 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 743721008806 DALR anticodon binding domain; Region: DALR_1; pfam05746 743721008807 anticodon binding site; other site 743721008808 tRNA binding surface [nucleotide binding]; other site 743721008809 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 743721008810 Surface antigen; Region: Bac_surface_Ag; pfam01103 743721008811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 743721008812 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 743721008813 nucleotide binding site [chemical binding]; other site 743721008814 Family of unknown function (DUF490); Region: DUF490; pfam04357 743721008815 Peptidase S46; Region: Peptidase_S46; pfam10459 743721008816 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 743721008817 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 743721008818 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 743721008819 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 743721008820 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 743721008821 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 743721008822 RNA binding site [nucleotide binding]; other site 743721008823 Cation efflux family; Region: Cation_efflux; cl00316 743721008824 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 743721008825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743721008826 dimerization interface [polypeptide binding]; other site 743721008827 putative DNA binding site [nucleotide binding]; other site 743721008828 putative Zn2+ binding site [ion binding]; other site 743721008829 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 743721008830 active site residue [active] 743721008831 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 743721008832 putative C-terminal domain interface [polypeptide binding]; other site 743721008833 putative GSH binding site (G-site) [chemical binding]; other site 743721008834 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743721008835 putative dimer interface [polypeptide binding]; other site 743721008836 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 743721008837 putative N-terminal domain interface [polypeptide binding]; other site 743721008838 putative dimer interface [polypeptide binding]; other site 743721008839 putative substrate binding pocket (H-site) [chemical binding]; other site 743721008840 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 743721008841 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 743721008842 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 743721008843 hypothetical protein; Provisional; Region: PRK06815 743721008844 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 743721008845 tetramer interface [polypeptide binding]; other site 743721008846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743721008847 catalytic residue [active] 743721008848 Uncharacterized conserved protein [Function unknown]; Region: COG1434 743721008849 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 743721008850 putative active site [active] 743721008851 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 743721008852 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 743721008853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721008854 S-adenosylmethionine binding site [chemical binding]; other site 743721008855 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 743721008856 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 743721008857 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 743721008858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743721008859 catalytic residue [active] 743721008860 biotin synthase; Region: bioB; TIGR00433 743721008861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743721008862 FeS/SAM binding site; other site 743721008863 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 743721008864 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 743721008865 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743721008866 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743721008867 DNA binding site [nucleotide binding] 743721008868 domain linker motif; other site 743721008869 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 743721008870 putative dimerization interface [polypeptide binding]; other site 743721008871 putative ligand binding site [chemical binding]; other site 743721008872 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 743721008873 dimerization interface [polypeptide binding]; other site 743721008874 putative active cleft [active] 743721008875 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 743721008876 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 743721008877 putative substrate binding site [chemical binding]; other site 743721008878 putative ATP binding site [chemical binding]; other site 743721008879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721008880 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 743721008881 putative substrate translocation pore; other site 743721008882 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 743721008883 UbiA prenyltransferase family; Region: UbiA; pfam01040 743721008884 tyrosine kinase; Provisional; Region: PRK11519 743721008885 Chain length determinant protein; Region: Wzz; pfam02706 743721008886 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 743721008887 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743721008888 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 743721008889 Low molecular weight phosphatase family; Region: LMWPc; cd00115 743721008890 active site 743721008891 polysaccharide export protein Wza; Provisional; Region: PRK15078 743721008892 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 743721008893 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 743721008894 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 743721008895 Bacterial sugar transferase; Region: Bac_transf; pfam02397 743721008896 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 743721008897 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 743721008898 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 743721008899 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 743721008900 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743721008901 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 743721008902 putative NAD(P) binding site [chemical binding]; other site 743721008903 active site 743721008904 putative substrate binding site [chemical binding]; other site 743721008905 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 743721008906 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 743721008907 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 743721008908 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 743721008909 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 743721008910 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743721008911 NAD binding site [chemical binding]; other site 743721008912 putative substrate binding site 2 [chemical binding]; other site 743721008913 putative substrate binding site 1 [chemical binding]; other site 743721008914 active site 743721008915 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 743721008916 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 743721008917 active site 743721008918 Predicted transcriptional regulator [Transcription]; Region: COG2378 743721008919 WYL domain; Region: WYL; pfam13280 743721008920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721008921 Walker A motif; other site 743721008922 ATP binding site [chemical binding]; other site 743721008923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743721008924 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 743721008925 Walker A motif; other site 743721008926 ATP binding site [chemical binding]; other site 743721008927 Walker B motif; other site 743721008928 arginine finger; other site 743721008929 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 743721008930 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 743721008931 active site 743721008932 DNA binding site [nucleotide binding] 743721008933 Int/Topo IB signature motif; other site 743721008934 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 743721008935 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 743721008936 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 743721008937 active site 743721008938 dimer interface [polypeptide binding]; other site 743721008939 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 743721008940 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 743721008941 active site 743721008942 FMN binding site [chemical binding]; other site 743721008943 substrate binding site [chemical binding]; other site 743721008944 3Fe-4S cluster binding site [ion binding]; other site 743721008945 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 743721008946 domain interface; other site 743721008947 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 743721008948 Benzoate membrane transport protein; Region: BenE; pfam03594 743721008949 benzoate transporter; Region: benE; TIGR00843 743721008950 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743721008951 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743721008952 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 743721008953 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 743721008954 active site 743721008955 dimer interface [polypeptide binding]; other site 743721008956 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 743721008957 substrate binding site [chemical binding]; other site 743721008958 NRDE protein; Region: NRDE; cl01315 743721008959 PAS fold; Region: PAS_2; pfam08446 743721008960 GAF domain; Region: GAF; pfam01590 743721008961 Phytochrome region; Region: PHY; pfam00360 743721008962 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 743721008963 heme binding pocket [chemical binding]; other site 743721008964 heme ligand [chemical binding]; other site 743721008965 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 743721008966 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 743721008967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743721008968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743721008969 Transglycosylase SLT domain; Region: SLT_2; pfam13406 743721008970 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743721008971 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743721008972 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 743721008973 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 743721008974 active site 743721008975 phosphate binding residues; other site 743721008976 catalytic residues [active] 743721008977 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 743721008978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743721008979 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 743721008980 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 743721008981 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 743721008982 hypothetical protein; Provisional; Region: PRK04233 743721008983 SEC-C motif; Region: SEC-C; pfam02810 743721008984 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 743721008985 GTP cyclohydrolase I; Provisional; Region: PLN03044 743721008986 active site 743721008987 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 743721008988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743721008989 metal binding site [ion binding]; metal-binding site 743721008990 active site 743721008991 I-site; other site 743721008992 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743721008993 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 743721008994 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 743721008995 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 743721008996 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 743721008997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743721008998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743721008999 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743721009000 E3 interaction surface; other site 743721009001 lipoyl attachment site [posttranslational modification]; other site 743721009002 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743721009003 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743721009004 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 743721009005 Walker A/P-loop; other site 743721009006 ATP binding site [chemical binding]; other site 743721009007 Q-loop/lid; other site 743721009008 ABC transporter signature motif; other site 743721009009 Walker B; other site 743721009010 D-loop; other site 743721009011 H-loop/switch region; other site 743721009012 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 743721009013 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 743721009014 heat shock protein 90; Provisional; Region: PRK05218 743721009015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743721009016 ATP binding site [chemical binding]; other site 743721009017 Mg2+ binding site [ion binding]; other site 743721009018 G-X-G motif; other site 743721009019 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 743721009020 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 743721009021 active site 743721009022 Zn binding site [ion binding]; other site 743721009023 Nuclease-related domain; Region: NERD; pfam08378 743721009024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 743721009025 ATP binding site [chemical binding]; other site 743721009026 putative Mg++ binding site [ion binding]; other site 743721009027 Family description; Region: UvrD_C_2; pfam13538 743721009028 Restriction endonuclease; Region: Mrr_cat; pfam04471 743721009029 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 743721009030 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 743721009031 active site 743721009032 Zn binding site [ion binding]; other site 743721009033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743721009034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721009035 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 743721009036 putative effector binding pocket; other site 743721009037 putative dimerization interface [polypeptide binding]; other site 743721009038 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 743721009039 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 743721009040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743721009041 NAD(P) binding site [chemical binding]; other site 743721009042 active site 743721009043 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 743721009044 AAA domain; Region: AAA_30; pfam13604 743721009045 Family description; Region: UvrD_C_2; pfam13538 743721009046 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 743721009047 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 743721009048 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 743721009049 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 743721009050 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 743721009051 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 743721009052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721009053 Walker A/P-loop; other site 743721009054 ATP binding site [chemical binding]; other site 743721009055 Q-loop/lid; other site 743721009056 ABC transporter signature motif; other site 743721009057 Walker B; other site 743721009058 D-loop; other site 743721009059 H-loop/switch region; other site 743721009060 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 743721009061 Permease; Region: Permease; pfam02405 743721009062 mce related protein; Region: MCE; pfam02470 743721009063 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 743721009064 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743721009065 anti sigma factor interaction site; other site 743721009066 regulatory phosphorylation site [posttranslational modification]; other site 743721009067 VacJ like lipoprotein; Region: VacJ; cl01073 743721009068 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 743721009069 RmuC family; Region: RmuC; pfam02646 743721009070 Protein of unknown function, DUF488; Region: DUF488; cl01246 743721009071 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 743721009072 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 743721009073 Na binding site [ion binding]; other site 743721009074 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 743721009075 classical (c) SDRs; Region: SDR_c; cd05233 743721009076 NAD(P) binding site [chemical binding]; other site 743721009077 active site 743721009078 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 743721009079 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 743721009080 putative RNA binding site [nucleotide binding]; other site 743721009081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743721009082 S-adenosylmethionine binding site [chemical binding]; other site 743721009083 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 743721009084 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 743721009085 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743721009086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743721009087 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 743721009088 dimerization interface [polypeptide binding]; other site 743721009089 substrate binding pocket [chemical binding]; other site 743721009090 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 743721009091 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 743721009092 Predicted methyltransferase [General function prediction only]; Region: COG4798 743721009093 Methyltransferase domain; Region: Methyltransf_23; pfam13489 743721009094 Uncharacterized conserved protein [Function unknown]; Region: COG1359 743721009095 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 743721009096 pseudouridine synthase; Region: TIGR00093 743721009097 active site 743721009098 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 743721009099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743721009100 ATP binding site [chemical binding]; other site 743721009101 putative Mg++ binding site [ion binding]; other site 743721009102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743721009103 nucleotide binding region [chemical binding]; other site 743721009104 Helicase associated domain (HA2); Region: HA2; pfam04408 743721009105 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 743721009106 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 743721009107 active site 743721009108 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743721009109 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743721009110 ligand binding site [chemical binding]; other site 743721009111 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 743721009112 TadE-like protein; Region: TadE; pfam07811 743721009113 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 743721009114 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 743721009115 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743721009116 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 743721009117 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743721009118 FHA domain; Region: FHA; pfam00498 743721009119 phosphopeptide binding site; other site 743721009120 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 743721009121 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 743721009122 ATP binding site [chemical binding]; other site 743721009123 Walker A motif; other site 743721009124 hexamer interface [polypeptide binding]; other site 743721009125 Walker B motif; other site 743721009126 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 743721009127 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743721009128 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 743721009129 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 743721009130 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 743721009131 Catalytic domain of Protein Kinases; Region: PKc; cd00180 743721009132 active site 743721009133 ATP binding site [chemical binding]; other site 743721009134 substrate binding site [chemical binding]; other site 743721009135 activation loop (A-loop); other site 743721009136 Tetratricopeptide repeat; Region: TPR_12; pfam13424 743721009137 Tetratricopeptide repeat; Region: TPR_12; pfam13424 743721009138 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 743721009139 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743721009140 DNA binding residues [nucleotide binding] 743721009141 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 743721009142 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 743721009143 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 743721009144 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 743721009145 inner membrane transport permease; Provisional; Region: PRK15066 743721009146 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743721009147 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 743721009148 Walker A/P-loop; other site 743721009149 ATP binding site [chemical binding]; other site 743721009150 Q-loop/lid; other site 743721009151 ABC transporter signature motif; other site 743721009152 Walker B; other site 743721009153 D-loop; other site 743721009154 H-loop/switch region; other site 743721009155 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743721009156 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 743721009157 FAD binding pocket [chemical binding]; other site 743721009158 conserved FAD binding motif [chemical binding]; other site 743721009159 phosphate binding motif [ion binding]; other site 743721009160 beta-alpha-beta structure motif; other site 743721009161 NAD binding pocket [chemical binding]; other site 743721009162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743721009163 non-specific DNA binding site [nucleotide binding]; other site 743721009164 salt bridge; other site 743721009165 sequence-specific DNA binding site [nucleotide binding]; other site 743721009166 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 743721009167 TAP-like protein; Region: Abhydrolase_4; pfam08386 743721009168 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743721009169 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 743721009170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743721009171 Walker A/P-loop; other site 743721009172 ATP binding site [chemical binding]; other site 743721009173 Q-loop/lid; other site 743721009174 ABC transporter signature motif; other site 743721009175 Walker B; other site 743721009176 D-loop; other site 743721009177 H-loop/switch region; other site 743721009178 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 743721009179 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 743721009180 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 743721009181 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743721009182 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 743721009183 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 743721009184 trmE is a tRNA modification GTPase; Region: trmE; cd04164 743721009185 G1 box; other site 743721009186 GTP/Mg2+ binding site [chemical binding]; other site 743721009187 Switch I region; other site 743721009188 G2 box; other site 743721009189 Switch II region; other site 743721009190 G3 box; other site 743721009191 G4 box; other site 743721009192 G5 box; other site 743721009193 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 743721009194 membrane protein insertase; Provisional; Region: PRK01318 743721009195 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 743721009196 Ribonuclease P; Region: Ribonuclease_P; cl00457 743721009197 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399