-- dump date 20140620_020750 -- class Genbank::CDS -- table cds_function -- id function YP_263309.1 initiation and regulation of chromosomal replication YP_263310.1 DNA polymerase III holoenzyme is responsible for most of the replicative synthesis in bacteria. The beta subunit is required for initiation of replication from an RNA primer. YP_263311.1 All proteins in this family for which functions are known are DNA binding proteins that assist the filamentation of RecA onto DNA for the initiation of recombination or recombinational repair. YP_263312.1 DNA gyrase catalyses the interconversion of topological isomers of DNA and play a key role in DNA metabolism. YP_263316.1 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate for regulatory purposes YP_263317.1 Biosynthesis of GMP from xanthosine 5'-monophosphate and ammonium (from glutamine) YP_263322.1 oxidoreductase activity :Members of this family catalyse the denitrification of a number of nitroalkanes using either FAD or FMN as a cofactor. YP_263335.1 chaperone activity YP_263336.1 Diaminopimelate biosynthesis, Lysine biosynthesis via diaminopimellate YP_263337.1 Putrescine biosynthesis YP_263343.1 First step of the glutathione biosynthesis pathway YP_263346.1 prc mutant suppressor YP_263347.1 DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. YP_263350.1 The DNA polymerase III holoenzyme is the polymerase responsible for the replication of the chromosome. YP_263351.1 Polypeptide degradation YP_263352.1 Ubiquinone synthesis YP_263358.1 The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini. YP_263360.1 Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. YP_263366.1 All proteins in this family (TIGR00634) for which functions are known are ATP binding proteins involved in the initiation of recombination and recombinational repair. YP_263369.1 Biosynthesis of pantothenate and CoA YP_263370.1 cysteine-type peptidase activity YP_263373.1 catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate YP_263376.1 transcriptional anti-termination Structural and functional similarities between RbfA, NusA, and other bacterial type II KH domains suggest previously unsuspected evolutionary relationships between cold- shock associated proteins YP_263393.1 Reversible aldol cleavage or condensation of fructose-1,6-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde 3-phosphate. YP_263396.1 Arginine biosynthesis and metabolism, Aspartate metabolism. YP_263397.1 Heme synthesis YP_263398.1 Heme synthesis YP_263401.1 Riboflavin synthesis YP_263416.1 transfer nucleotides onto phosphosugars. YP_263417.1 catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate YP_263423.1 Folate synthesis YP_263424.1 Biosynthesis of pantothenate and CoA YP_263425.1 Synthesis of pantothenate and CoA YP_263429.1 Last step in ubiquinone synthesis YP_263430.1 hydrolase activity YP_263431.1 oxidoreductase activity YP_263432.1 DksA is involved in translational regulation of RpoS YP_263447.1 Aromatic amino acid biosynthesis, Chorismate biosynthesis YP_263451.1 Recognizes and cleaves methylated sequences. YP_263453.1 Phosphorylation of dTMP to dTDP YP_263455.1 Degradation of polypeptides YP_263456.1 Diaminopimellate biosynthesis, Lysine biosynthesis via the diaminopimellate pathway YP_263458.1 'de novo' Purine biosynthesis YP_263465.1 Deamination of D-amino acids YP_263468.1 Heme synthesis YP_263470.1 It catalyzes the first step in the synthesis of long-chain fatty acids which involves the carboxylation of acetyl-CoA to malonyl-CoA YP_263472.1 Proline biosynthesis YP_263474.1 Thiamine synthesis YP_263476.1 Alanine synthesis YP_263477.1 Peptidyl-tRNA hydrolase (PTH) is a bacterial enzyme that cleaves peptidyl-tRNA or N-acyl-aminoacyl-tRNA to yield free peptides or N-acyl-amino acids and tRNA. YP_263479.1 Pentose Phosphate Pathway -> Histidine biosynthesis, pyrimidine biosynthesis, and purine biosynthesis YP_263480.1 Isopentenyl diphosphate synthesis YP_263483.1 Heme synthesis YP_263484.1 Serine biosynthesis and metabolism YP_263487.1 catalytic activity YP_263494.1 'de novo' Purine biosynthesis YP_263498.1 Folate synthesis YP_263502.1 NAD synthesis YP_263506.1 Lysine biosynthesis via the diaminopimellate pathway. YP_263507.1 Lysine biosynthesis via diaminopimellate synthase YP_263508.1 Possible site-specific recombinase that acts on cer sequence of ColE1, effects chromosome segregation at cell division. YP_263509.1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds YP_263510.1 required for the transcription of promoters that have a characteristic -24 and -12 consensus recognition element but which are devoid of the typical -10,-35 sequences recognized by the major sigma factors. YP_263511.1 possible binding to sigma factor 54. implicated in biofilm formation in Bacillus and quorom sensing in P. stutzeri YP_263514.1 DNA binding (GO:0003677) transcription factor activity (GO:0003700) DNA-directed RNA polymerase activity (GO:0003899) sigma factor activity (GO:0016987) YP_263521.1 proteolysis and peptidolysis YP_263523.1 The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. YP_263525.1 Pyruvate metabolism, Lactate biosynthesis YP_263526.1 Synthesis of heme YP_263527.1 Riboflavin synthesis YP_263528.1 Catalyzes the thiamine pyrophosphoate-dependent acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate; synthesis isopentenyl diphosphate YP_263529.1 inositol/phosphatidylinositol phosphatase activity YP_263531.1 Biosynthesis of thiamine YP_263533.1 endonuclease activity for DNA repair YP_263537.1 natural transformation with exogenous DNA YP_263551.1 This family of proteins is named after the Salmonella typhimurium MutS protein that is involved in replication repair and plays a role in preventing recombination between non-identical sequences. YP_263557.1 Threonine biosynthesis, Lysine biosynthesis YP_263558.1 Required for disulfide bond formation in some periplasmic proteins. YP_263568.1 possibly involved in maintaining the structural integrity of the cell envelope YP_263569.1 The Ferric uptake regulator or FUR family includes metal ion uptake regulator proteins, which bind to the operator DNA and control the transcription of metal ion-responsive genes. YP_263571.1 Pilus retraction protein: required for twitching motility and social gliding. Protein involved in type II secretion. YP_263574.1 NAD synthesis YP_263576.1 Pyridoxal (B6) synthesis YP_263579.1 'de novo' purine biosynthesis YP_263580.1 'de novo' Purine biosynthesis YP_263582.1 peptidase activity YP_263584.1 Possible porin-like integral membrane proteins YP_263585.1 hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. YP_263586.1 Proteolysis and peptidolysis: serine-type peptidase activity YP_263590.1 tRNA and rRNA base modification YP_263593.1 Ubiquinone synthesis YP_263594.1 Glysine metabolism and biosynthesis, Serine metabolism and biosynthesis, Lysine degradation YP_263596.1 RNA binding (GO:0003723) endoribonuclease activity (GO:0004521) YP_263597.1 Proline biosynthesis YP_263603.1 catalytic activity YP_263613.1 Leucine, Isoleucine, and Valine degradation, Propionate metabolism YP_263614.1 Leucine, Isoleucine, and Valine Degradation, Lysine Degradation, Beta-alanine metabolism, Tryptophan metabolism YP_263615.1 Leucine, Isoleucine, and Valine Degradation YP_263616.1 Leucine degradation, Butanoate metabolism YP_263617.1 Leucine degradation YP_263619.1 Attaches biotin to lysine within active site of biotin enzymes YP_263621.1 The SMC proteins are essential for successful chromosome transmission during replication and segregation of the genome. YP_263623.1 DNA ligase catalyses the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising NAD(+) as a cofactor. YP_263628.1 recognizes stalled ribosomes such as occur during translation from message that lacks a stop codon. YP_263629.1 Biosynthesis of pantothenate and CoA YP_263631.1 Biotin synthesis YP_263632.1 Biotin synthesis YP_263637.1 Involved in cell growth (cell division), with a function of GTP binding. YP_263638.1 Involved in RecF pathway of recombination. YP_263639.1 B6 synthesis YP_263645.1 Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines from damaged DNA (base excision repair). YP_263646.1 RelA produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT degrades ppGpp, but may also act as a secondary ppGpp synthetase YP_263649.1 Cysteine Metabolism, Selenoamino Acid Metabolism, Sulfur Metabolism: Fixation YP_263650.1 two component signal transduction YP_263655.1 Bacterial lytic transglycosylases degrade murein via cleavage of the beta-1,4- glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine, with the concomitant formation of a 1,6-anhydrobond in the muramic acid residue. YP_263661.1 protein folding YP_263662.1 Autonomous mobile genetic elements such as transposon or insertion sequences (IS) encode an enzyme, transposase, that is required for excising and inserting the mobile element. YP_263668.1 electron transporter activity YP_263669.1 hydrolase activity:adenine deaminase that hydrolyses adenine to form hypoxanthine and ammonia which is important for adenine utilization as a purine and also as a nitrogen source YP_263672.1 Serine biosynthesis and metabolism YP_263673.1 cyanide detoxification YP_263678.1 Methionine metabolism, Sulfur Fixation and Metabolism YP_263679.1 Heme synthesis YP_263681.1 DNA-directed DNA polymerases are the key enzymes catalyzing the accurate replication of DNA. They require either a small RNA molecule or a protein as a primer for the de novo synthesis of a DNA chain. This protein also contains 5'-3' exonuclease domains. YP_263682.1 Involved in response to stress: organic hydroperoxide detoxification YP_263689.1 Controls protein half-life through N-end rule degradation pathway. YP_263691.1 A mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification. YP_263693.1 The epsilon subunit contains the proofreading 3' -> 5' exonuclease activity of DNA polymerase III core enzyme (responsible for chromosome replication). YP_263695.1 Aminotransferase, Lysine biosynthesis? YP_263697.1 Signal transduction: Inactivates protein PII -> upregulation of glutamine synthesis genes YP_263702.1 C-5 cytosine-specific DNA methylases specifically methylate the C-5 carbon of cytosines in DNA to produce C5-methylcytosine. In bacteria, these enzymes are a component of restriction-modification systems. YP_263704.1 Methionine biosynthesis and metabolism YP_263707.1 Autonomous mobile genetic elements such as transposon or insertion sequences (IS) encode an enzyme, transposase, that is required for excising and inserting the mobile element. YP_263712.1 Autonomous mobile genetic elements such as transposon or insertion sequences (IS) encode an enzyme, transposase, that is required for excising and inserting the mobile element. YP_263715.1 Glutathione metabolism, Conjugates Glutathione with a variety of hydrocarbons. YP_263718.1 acyltransferase activity YP_263727.1 DNA photolyases are enzymes that bind to DNA containing pyrimidine dimers (induced by exposure to UV): on absorption of visible light, they catalyse dimer splitting into the constituent monomers, a process called photoreactivation. YP_263728.1 Tryptophan biosynthesis YP_263729.1 Trytophan biosynthesis YP_263730.1 Tryptophan biosynthesis YP_263732.1 Folate synthesis YP_263733.1 This domain is about 40 residues long and is found in a variety of enzymes involved in bacterial cell wall degradation. YP_263744.1 Reverse transcriptase uses an RNA template to produce DNA, for integration into the host genome and exploitation of a host cell (strategy employed in the replication of retroid elements, such as the retroviruses and bacterial retrons). YP_263760.1 it forms the junction between the phage head (capsid) and the tail proteins YP_263761.1 Terminases cleave the cohesive ends of lambda family phage. YP_263762.1 Terminases cleave the cohesive ends of lambda family phage. YP_263776.1 Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. YP_263777.1 -This enzyme functions as an alternative to a direct Gln-tRNA synthetase (Gln--tRNA ligase) in mitochondria, chloroplasts, gram-positive bacteria, cyanobacteria, and the Archaea. YP_263780.1 The role in Biosynthesis of murein sacculus and peptidoglycan YP_263783.1 inhibitor of septum formation YP_263822.1 annotated for E.coli as kinase YP_263824.1 Biosynthesis of pantothenate and CoA; Metabolism of amino acids YP_263825.1 Biosynthesis of pantothenate and CoA; Metabolism of amino acids YP_263826.1 Biosynthesis of pantothenate and CoA; Synthesis of branched chain amino acids YP_263828.1 DNA-binding domain, Csp A YP_263837.1 'de novo' Pyrimidine biosynthesis, Aspartate metabolism YP_263844.1 regulation of transcription: involved in the biosynthesis and uptake of the amino acid tryptophan YP_263856.1 Diaminopimellate biosynthesis, Lysine biosynthesis YP_263869.1 DNA polymerase III, delta subunit is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction. YP_263874.1 Arginine biosynthesis YP_263875.1 Pyrimidine metabolism: Cleaves dUTP into dUMP and pyrophosphate. YP_263877.1 Members of this family are helicases that catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA. The family includes both Rep and UvrD helcases. UvrD functions in nucleotide excision repair. YP_263897.1 Nitrate/nitrite two-component sensor system YP_263906.1 Synthesis of molybdopterin YP_263910.1 Molybdopterin synthesis YP_263921.1 Ubiquinone synthesis YP_263922.1 Ubiquinone synthesis YP_263924.1 NAD synthesis YP_263925.1 NAD synthesis YP_263927.1 NAD synthesis YP_263930.1 Integrase, catalytic domain YP_263933.1 Integrase, catalytic domain YP_263941.1 protein tyrosine phosphatase activity YP_263944.1 possible polysaccharide biosynthesis YP_263945.1 possible role in polysaccharide or protein efflux see J Bacteriol. 1990 Jun;172(6):3131-7. YP_263949.1 Acylneuraminate cytidylyltransferase catalyzes the reaction of CTP and NeuAc to form CMP-NeuAc, which is the nucleotide sugar donor used by sialyltransferases. The outer membrane lipooligosaccharides of some microorganisms contain terminal YP_263952.1 Catalyzes reaction: L-Methionyl-tRNA + 10-Formyltetrahydrofolate <=> Tetrahydrofolate + N-Formylmethionyl-tRNA YP_263953.1 N-acetylneuraminic acid (Neu5Ac) synthase. It catalyses the direct formation of Neu5Ac (the most common sialic acid) by condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine (ManNAc). YP_263954.1 from Interpro: Although most of the proteins in this group are of unknown function one, from Schizosaccharomyces pombe, has been characterised as a probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase. YP_263955.1 antifreeze domain present YP_263958.1 Asparagine biosynthesis, Glutamine -> Glutamate YP_263960.1 The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases YP_263961.1 Asparagine biosynthesis, Glutamine -> Glutamate YP_263965.1 The integral inner-membrane proteins translocate the substrate across the membrane. YP_263969.1 Histidine Biosynthesis YP_263970.1 Purine biosynthesis: synthesis of AMP from IMP. YP_263971.1 Phosphorylation of GDP, CDP, and UDP and dTDP YP_263973.1 pilus assembly protein YP_263975.1 Isopentenyl diphosphate synthesis YP_263983.1 Probably involved in the cleavage of amino acids, specifically glycine bonds. They lyse the cell walls of Gram-positive bacteria YP_263985.1 possible UDP-2,3-diacylglucosamine hydrolase YP_263986.1 PPIase is an enzyme that accelerates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides PUB00005503. (from PFAM) YP_263987.1 Catalysis of the attachment of an amino acid to its cognate transfer RNA molecule YP_263992.1 Endonuclease that resolves Holliday junction intermediates in genetic recombination. The active form of the protein is a dimer. YP_263993.1 Probably involved in phage T7 exclusion YP_263996.1 This sequence contains both a regulatory protein domain and a response regulator domain YP_263997.1 Bacterial serine protease YP_263998.1 Thiamine synthesis YP_263999.1 PGK is an enzyme that catalyzes the formation of ATP to ADP and vice versa. YP_264001.1 Involved in glycolysis. Catalyses reversible aldol cleavage or condensation of fructose-1,6-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde 3-phosphate. YP_264002.1 RuvA forms a complex with RuvB, this complex is a helicase that mediates the Holliday junction migration by localised denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. YP_264003.1 All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. YP_264006.1 Ubiquinone synthesis YP_264010.1 Metabolism and biosynthesis of tyrosine, phenylalanine, glutamate, aspartate, cysteine, and proline YP_264012.1 two component regulation YP_264016.1 Betaine biosynthesis YP_264017.1 Betaine biosynthesis YP_264018.1 HTH motif suggests regulatory function YP_264019.1 Transport of cations or cationic drugs YP_264021.1 All proteins in this family are 5'-3' single-strand DNA exonucleases. These proteins are used in some aspects of mismatch repair, recombination, and recombinational repair. YP_264025.1 Lysine biosynthesis via the diaminopimellate pathway, Diaminopimellate biosynthesis YP_264032.1 UvrB is a DNA helicase that functions in the nucleotide excision repair and is an endonuclease that make the 3' incision next to DNA damage. They are part of a pathway requiring UvrA, UvrB, UvrC, and UvrD homologs. YP_264053.1 RNA modification. YP_264072.1 transports DNA across the cell membrane YP_264073.1 Protease IV:signal peptide processing YP_264079.1 Methionine biosynthesis: Interconverts O-succinyl-L-homoserine -> cystithione -> O-acetylhomoserine -> homocysteine YP_264081.1 All proteins in this family for which functions are known are involved in the initiation of recombination and recombinational repair. RecF is also required. YP_264083.1 Glycine metabolism, Glycine cleavage system YP_264085.1 Glycine metabolism, Glycine cleavage system YP_264086.1 Glycine metabolism, Glycine cleavage system YP_264096.1 Glutamate metabolism, Alanine and Aspartate metabolism, beta-Alanine metabolism, Propionate metabolism, Butanoate metabolism YP_264100.1 ndogenous, endonucleolytic transcript cleavage activity of the RNA polymerase (RNAP), allowing RNA transcription to continue past template-encoded arresting sites. YP_264101.1 Pyrimindine biosynthesis, Arginine biosynthesis YP_264102.1 Pyrimidine biosynthesis, Arginine biosynthesis YP_264116.1 Endonuclease III is a DNA repair enzyme which removes a number of damaged pyrimidines from DNA via its glycosylase activity and also cleaves the phosphodiester backbone at apurinic/ apyrimidinic sites via a beta-elimination mechanism. YP_264118.1 NUDIX hydrolases (NUcleoside DIphosphate linked to some other moiety X) can be divided into a number of subgroups. Most hydrolyse diverse nucleoside diphosphate derivatives (including ADP-ribose, GDP- mannose, TDP-glucose, NADH, UDP-sugars, dNTP and NTP). YP_264120.1 The epsiolon subunit is responsible for the proofreading 3'-5' exonuclease activit of the DNA polymerase III core enzyme. The RNase H domain is responsible for hydrolysis of the RNA portion of RNA x DNA hybrids. YP_264127.1 ChrR is sufficient to inhibit sigma(E)-dependent transcription. Inhibition is proposed to proceed through a binding interaction, since sigma(E) and ChrR form a 1:1 complex that can be purified when expressed at high levels in Escherichia coli YP_264133.1 Methionine biosynthesis YP_264134.1 oxidoreductase activity: electron transport YP_264136.1 Integrase, catalytic domain YP_264138.1 thioesterase hydrolase YP_264139.1 part of a glucose utilization pathway whereby glucose is converted to pentose YP_264150.1 Transposases are necessary for efficient DNA transposition. YP_264151.1 Transposases are necessary for efficient DNA transposition. YP_264164.1 Site-specific DNA-methyltransferase (adenine-specific) activity: part of the restriction-modification system. YP_264173.1 Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. YP_264177.1 TatD has been shown experimentally to be a DNase enzyme. YP_264178.1 contains helix turn helix motif of several transcriptional regulators of TetR family not enough info for sub- family YP_264180.1 dGTP -> dG + triphosphate. YP_264191.1 Valine degradation YP_264194.1 Metabolism of CoA YP_264196.1 Glutathione metabolism, Peptide degradation YP_264197.1 Chorismate biosynthesis, aromatic amino acid biosynthesis YP_264199.1 Ribonuclease HII is involved in the degradation of the ribonucleotide moiety on RNA-DNA hybrid molecules carrying out endonucleolytic cleavage to 5'-phospo-monoester. YP_264204.1 possible 6-pyruvoyl tetrahydropterin synthase YP_264207.1 possible tRNA modifications YP_264208.1 The bacterial Hfq protein is an abundant RNA-binding protein which modulates the stability or the translation of mRNAs and has recently been shown to interact with small regulatory RNAs in Escherichia coli. Hfq is involved also in the expression of many c YP_264214.1 RadA/Sms is involved in recombination and recombinational repair, most likely involving the stabilization or processing of branched DNA molecules or blocked replication forks because of its genetic redundancy with RecG and RuvABC. YP_264218.1 Protein degradation YP_264222.1 The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase. YP_264228.1 Chorismate biosynthesis, aromatic amino acid biosynthesis YP_264236.1 protein amino acid dephosphorylation YP_264238.1 Serine metabolism, Threonine metabolism, Isoleucine biosynthesis YP_264243.1 Ribose 5-phosphate isomerase, also known as phosphoriboisomerase, catalyses the conversion of D-ribose 5-phosphate to D-ribulose 5-phosphate in the non-oxidative branch of the pentose phosphate pathway. YP_264244.1 Arginine biosynthesis and metabolism YP_264245.1 L- alanine to D- alanine for peptidoglycan synthesis YP_264246.1 The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. YP_264247.1 B6 synthesis YP_264249.1 Degradation of Diadenosine 5',5''-P1,P4-tetraphosphate (Ap4A), a regulatory metabolite of stress conditions YP_264254.1 Methane metabolism, C1 Metabolism by Folate YP_264255.1 Selenoamino acid metabolism, Methionine metabolism YP_264258.1 MutS2 binds to damaged DNA YP_264259.1 Tryptophan biosynthesis. YP_264260.1 Tryptophan biosynthesis YP_264261.1 Tryptophan biosynthesis YP_264262.1 Glutamine biosynthesis, Nitrogen metabolism, Peptidoglycan synthesis YP_264264.1 Predicted outer membrane/secreted protein. YP_264267.1 C-5 cytosine-specific DNA methylases are enzymes that specifically methylate the C-5 carbon of cytosines in DNA to produce C5-methylcytosine. In bacteria, these enzymes are a component of restriction-modification systems. YP_264269.1 Predicted endonuclease, gp47 [Bacteriophage A118] related. YP_264276.1 serine protease YP_264288.1 ATP/GTP-binding site motif A (P-loop): YP_264290.1 from Interpro: This family of sequences are identified by a region of about 110 amino acids found exclusively in phage-related proteins, internally or toward the C terminus. One member, gp7 of phage SPP1, appears to be involved in head morphogenesis. YP_264291.1 from interpro: This family belongs to family U7 of the peptidase classification, and includes the potential protease SohB, a suppressor of the HTRA phenotype; and protease IV, an endopeptidase required to maintain proper secretion of mature proteins acros YP_264296.1 ATP/GTP-binding site motif A (P-loop): Phage virion morphogenesisThese sequences describe protein S of phage P2, suggested experimentally to act in tail completion and stable head joining, and related proteins from a number of phages. YP_264323.1 Serine biosynthesis, Vitamin-B6 metabolism YP_264330.1 Peptide methionine sulphoxide reductase reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide, Met(O), to methionine. YP_264331.1 Folate synthesis YP_264341.1 DNA polymerase III holoenzyme is responsible for the replication of the chromosome in bacteria. Both the gamma and tau subunits are 'motor' ATPases. YP_264342.1 The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini. YP_264343.1 Arginine biosynthesis YP_264346.1 Protein kinase YP_264347.1 Purine biosynthesis YP_264348.1 Glutamate metabolism YP_264349.1 SbcCD is an ATP-dependent double-stranded DNA exonuclease. This complex functions in the initiation of recombination and recombinational repair and is particularly important in regulating the stability of DNA sections that can form secondary structures. YP_264350.1 SbcCD is a double-stranded DNA exonuclease. This complex functions in the initiation of recombination and recombinational repair and is particularly important in regulating the stability of DNA sections that can form secondary structures. YP_264351.1 Heme synthesis YP_264352.1 Sulphur metabolism YP_264354.1 Selenoaminoacid metabolism and Sulfur fixation YP_264355.1 Sulphur metabolism, Purine metabolism, Selenoamino acid metabolism YP_264361.1 trans-acting metalloregulatory protein for metal resistance in E.coli YP_264364.1 Bacterioferritin (BFR; also known as cytochrome b1 or cytochrome b557) of Escherichia coli is an iron-storage protein consisting of 24 identical subunits that pack together to form a highly symmetrical, nearly spherical shell surrounding a central ca YP_264366.1 Bacterial GSTs of known function often have a specific, growth-supporting role in biodegradative metabolism: epoxide ring opening and tetrachlorohydroquinone reductive dehalogenation are two examples of the reactions catalysed by these bacterial GSTs. Som YP_264379.1 The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini. YP_264383.1 Involved in the utilization of lactams such as 2-pyrrolidinone YP_264384.1 possibly functions with subunit1 converts urea-1-carboxylate and water to 2 carbon dioxide and 2 ammonia YP_264393.1 The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini. YP_264403.1 cell-cell signalling protein YP_264406.1 provides power for ArsB to pump out arsenite and antimonite YP_264410.1 Purine metabolism: May act on all substrates above to produce nucleoside 5'-monophosphates. YP_264411.1 Exoribodeoxynuclease V unwinds and degrades double stranded DNA prior to recombination. When chi sites are encountered, the alpha subunit (recD) is released and degradation stops while unwinding continues. YP_264412.1 Exoribodeoxynuclease V unwinds and degrades double stranded DNA prior to recombination. When chi sites are encountered, the alpha subunit (recD) is released and degradation stops while unwinding continues. YP_264413.1 Exoribodeoxynuclease V unwinds and degrades double stranded DNA prior to recombination. When chi sites are encountered, the alpha subunit (recD) is released and degradation stops while unwinding continues. YP_264417.1 The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. YP_264440.1 Degradation of purine-nucleosides to purine and alpha-D-ribose 1-phosphate. YP_264449.1 dgkA is an enzyme that catalyzes the formation of phosphatidic acid from diacylglycerol and ATP, an important step in phospholipid biosynthesis. YP_264458.1 uptake of short/medium chain saturated dicarboxylates YP_264461.1 Glutathione metabolism: Tranfers gamma-glutamate residue from glutathione to L-amino acids. Detoxification of drugs and xenobiotics YP_264462.1 The DNA polymerase III holoenzyme is responsible for the replication of the chromosome. YP_264465.1 Cysteine biosynthesis YP_264467.1 Folate synthesis YP_264469.1 Chorismate and tyrosine biosynthesis YP_264470.1 Phenylalanine metabolism and biosynthesis, histidine metabolism, tyrosine metabolism. YP_264471.1 Phenylalanine biosynthesis YP_264472.1 catalyzes the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate together with transketolase link the glycolytic and pentose-phosphate pathwa YP_264474.1 Purine metabolism: Biosynthesis of AMP from Adenine, Biosynthesis of 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide from 5-amino-4-imidazolecarboxyamide YP_264475.1 Rubredoxin is a low molecular weight iron-containing bacterial protein involved in electron transfer sometimes replacing ferredoxin as an electron carrier YP_264481.1 Serine metabolism, Cysteine metabolism YP_264483.1 Arginine biosynthesis YP_264484.1 All proteins in this family for which functions are known are 5' AP endonucleases that function in base excision repair and the repair of abasic sites in DNA. YP_264486.1 oxidoreductase activity YP_264487.1 serine-type endopeptidase activity YP_264500.1 Leucine biosynthesis and degradation. CoA biosynthesis. YP_264501.1 Regulates glutamate-ammonia ligase by adenylation in response to cellular nitrogen status. YP_264513.1 Leucine biosynthesis YP_264514.1 helix turn helix motif suggestd transcriptional regulation YP_264516.1 protein kinase activity (amino acid phosphorylation) YP_264518.1 Possibly involved in ubiquinone synthesis YP_264519.1 Probably acts as a uuptake transporter and signal transducer in the beta-lactamase induction system and in peptidoglycan recycling. YP_264520.1 The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini. YP_264527.1 Isopentenyl diphosphate synthesis YP_264529.1 'de novo' Purine biosynthesis: Biosynthesis of Inosine monophosphate, Biosynthesis of Adenosine monophosphate YP_264539.1 integral membrane proteins of unknown function YP_264543.1 DNA primase is a nucleotidyltransferase that synthesises the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand. YP_264544.1 DNA binding (GO:0003677) transcription factor activity (GO:0003700) DNA-directed RNA polymerase activity (GO:0003899) sigma factor activity (GO:0016987) YP_264547.1 Interconversion of Ribonucleotides and Deoxyribonucleotides YP_264552.1 Interconversion of Ribonucleotides and Deoxyribonucleotides YP_264564.1 eflux of branched chain amino acids YP_264565.1 Possible branched chain amino acid efflux pump, LivE family, small subunit YP_264566.1 Purine biosynthesis, Glutamate metabolism: Glutamine is amine donor YP_264568.1 Pyrimidine biosynthesis YP_264577.1 NAD synthesis YP_264579.1 Adds lipoate to enzymes requiring lipoic acid in the active site. YP_264588.1 Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid. 6- YP_264590.1 catalyses the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics YP_264597.1 DNA polymerase III, delta' subunit is required for, along with delta subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction. YP_264599.1 Lipid A biosynthesis YP_264613.1 contains helix turn helix motif so probably has regulatory function YP_264619.1 pyruvate, water dikinase activity in gluconeogenesis YP_264633.1 contains helix turn helix motif of several transcriptional regulators of TetR family not enough info for sub- family YP_264640.1 B6 synthesis YP_264641.1 intramolecular transferase activity, phosphotransferases YP_264642.1 Purine metabolism: GMP biosynthesis YP_264650.1 adds the CCA to the 3' of the tRNA EC: 2.7.7.25. YP_264670.1 Glycine and Serine interconversion YP_264671.1 Threonine biosynthesis and metabolism, Serine biosynthesis and metabolism YP_264672.1 Cleaves 3-hydroxyaspartate into glyoxylate and glycine YP_264673.1 Proline biosynthesis YP_264677.1 Many of these proteins function as repressors that control the level of susceptibility to hydrophobic antibiotics and detergents. YP_264685.1 Phenylalanine biosynthesis and metabolism, Tyrosine biosynthesis and metabolism YP_264687.1 contains LYsM domain may have a general peptidoglycan binding function. YP_264689.1 Asparagine metabolism to aspartate, Nitrogen metabolism YP_264691.1 translation initiation factor YP_264692.1 Leucine biosynthesis YP_264694.1 Leucine biosynthesis YP_264695.1 Leucine biosynthesis YP_264696.1 The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini. YP_264699.1 possibly involved in long chain fatty acid uptake (FadL - E. coli) or toluene and other organic compounds YP_264706.1 binds to ssrA tagged proteins and enchances ClpX degradation of incomplete protein products. YP_264707.1 Conversion of dCTP to dUTP YP_264720.1 likely to belong to two-component sensory transduction system where the protein is activated by its phosphorylation, generally on an aspartate residue, by a transmembrane kinase. The proteins that belong to this class include bvgA, comA, dctR; degU, evgA YP_264732.1 Acetone metabolism: catabolism YP_264733.1 5-Oxoprolinase catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate. YP_264737.1 Chorismate biosynthesis, Aromatic amino acid biosynthesis YP_264738.1 protein amino acid methylation YP_264742.1 Catalyse the attachment of an amino acid to its cognate transfer RNA molecule YP_264743.1 Biosynthesis of Lysine, Diaminopimellate, Methionine and Threonine from Aspartate YP_264744.1 Modulates the expression of genes in the glycogen biosynthesis and gluconeogenesis pathways by accelerating the 5'-to-3' degradation of these transcripts through selective RNA binding. YP_264747.1 phosphorylation of NAD to NADP YP_264750.1 responsible for the final stages of peptidoglycan biosynthesis for cell wall formation YP_264752.1 Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11 YP_264754.1 'de novo' synthesis of Purines: Biosynthesis of Inosine monophosphate YP_264755.1 accelerates protein folding YP_264756.1 The exact function of these proteins is not yet clear but they are capable of wrapping DNA and stabilizing it from denaturation under extreme environmental conditions. YP_264759.1 Iron-sulfur cluster assembly YP_264763.1 assisting folding newly translated proteins;guiding translocating proteins across organellar membranes; disassembling oligomeric protein structures;facilitating proteolytic degradation, etc... YP_264765.1 nucleotide hydrolases and transferases YP_264766.1 DNA-dependent ATPases that function in the process of transcription-coupled DNA repair in which the repair of the transcribed strand of actively transcribed genes is repaired at a higher rate than the repair of non-transcribed regions of the genome YP_264767.1 Menaquinone synthesis YP_264768.1 closest fits to epimerases and dehydrogenases (38% identity) of carbohydtrate metabolism YP_264771.1 hydrolase activity YP_264773.1 'de novo' Pyrmidine biosynthesis: Orotidine 5' phosphate to UMP. YP_264775.1 The exact function of these proteins is not yet clear but they are capable of wrapping DNA and stabilizing it from denaturation under extreme environmental conditions. YP_264777.1 Phosphorylates UMP, CMP or dCMP to U/CDP using ATP or GTP YP_264778.1 Hydrolyzes dCMP into dUMP YP_264779.1 Uracil-DNA glycosylase is a DNA repair enzyme that excises uracil residues from DNA by cleaving the N-glycosylic bond. Uracil in DNA can arise as a result of misincorportation of dUMP residues by DNA polymerase or deamination of cytosine. YP_264781.1 Modifies substrate specifity of the ClpA chaperone. ClpA targets proteins for degradation. YP_264783.1 Ornithine biosynthesis YP_264784.1 Heme synthesis YP_264785.1 Proline biosynthesis YP_264786.1 uncertain function: but seems important in development and normal cell metabolism YP_264787.1 Part of the glycolysis pathway YP_264789.1 NUDIX hydrolases (NUcleoside DIphosphate linked to some other moiety X) hydrolyse diverse nucleoside diphosphate derivatives (including ADP-ribose, TDP-glucose, NADH, UDP-sugars, dNTP and NTP). MutT, anti- mutagenic activity, also shares this domain. YP_264796.1 possible esterase family ? YP_264799.1 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis YP_264802.1 enzyme that accelerates protein folding YP_264804.1 possible endonuclease/exonuclease/phosphatase YP_264805.1 Biosynthesis of Lysine, Diaminopimellate, Methionine, and Threonine from Aspartate. YP_264807.1 sodium symporter activity, possible amino acid symporter YP_264810.1 Enzyme for the biosynthesis of lipid A, a component oflipopolysaccharide (LPS) YP_264812.1 Degradation of proteins, peptides, and glycopeptides YP_264813.1 Isopentenyl diphosphate synthesis YP_264815.1 Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides. Used as a carrier in synthesizing cell wall components. YP_264816.1 releasing ribosomes from mRNA at the end of protein biosynthesis, it prevents inappropriate translation from 3-prime regions of the mRNA and frees the ribosome for new rounds of translation. YP_264817.1 Nucleotide Metabolism YP_264818.1 Expected to modify bases in tRNA. Function unknown. YP_264819.1 possible nitrogen regulation YP_264821.1 protein amino acid phosphorylation YP_264824.1 growth-supporting role in biodegradative metabolism YP_264825.1 Topoisomerases are ubiquitous enzymes that catalyze cleavage and religation of DNA molecules allowing for the interconversion of topological isomers of DNA and play a key role in DNA metabolism. YP_264834.1 exonuclease activity YP_264835.1 GTPase within DUF258 domain also contains sigma 54 interactig domain o most likelyinvolved in transcritional reression or signal recieving YP_264837.1 electron transporter activity YP_264839.1 Purine metabolism, Phosphorylation of AMP to ADP. YP_264842.1 disulfide oxidoreductase activity YP_264845.1 responsible for the final stages of peptidoglycan biosynthesis for cell wall formation YP_264852.1 probable nucleotide binding due to presence of helix turn helix motif YP_264856.1 Ubiquinone synthesis YP_264857.1 part of RND multidrug/dye/detergent efflux pump YP_264859.1 part of RND multidrug/dye/detergent efflux pump YP_264860.1 Heme synthesis YP_264865.1 nickel resistance YP_264870.1 Cell competence YP_264878.1 Chemotaxis. Members of this family contain a response regulator receiver domain (IPR001789) and an associated transcriptional regulatory region (IPR001867). YP_264893.1 AAA -This family is now called AAA, for ATPases Associated with diverse cellular Activities. The proteins that belong to this family either contain one or two AAA domains. YP_264899.1 glycolaldhydetransferase based on KEGG scores YP_264902.1 A ferritin homolog that binds and protects DNA from oxidative damage. YP_264904.1 Initiation and regulation of chromosomal replication. DnaA is an ATP- and DNA-binding protein. YP_264906.1 'de novo' synthesis of Purines: Biosynthesis of Inosine monophosphate YP_264907.1 'de novo' Purine synthesis: Biosynthesis of Inosine monophosphate YP_264908.1 Bind DNA via a helix-turn-helix (HTH) motif.The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. YP_264913.1 Arginine metabolism YP_264914.1 Pyrimidine biosynthesis: Biosyntheis of Uridine monophosphate YP_264915.1 RNase T removes the terminal AMP residue from uncharged tRNA. Inolved in RNA maturation and acts as a 3' to 5' single-strand DNA-specific exonuclease (distinctive for ability to remove residues near a double-stranded stem). YP_264916.1 Isopentenyl diphosphate synthesis YP_264918.1 catalyses the interconversion of 2-phosphoglycerate and phosphoenolpyruvate YP_264921.1 possible heavy metal associated protein, weak hits to copZ and heavy metal ATPases YP_264922.1 Involved in ketodeoxyoctanoate biosynthesis: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides. YP_264923.1 CTP biosynthesis from UTP and ammonium (from glutamine) YP_264937.1 Peptidase YP_264938.1 possibly acts as a scaffolding agent for subunits of a murein sacculus-synthesizing holoenzyme YP_264940.1 One carbon pool by folate YP_264942.1 DNA topoisomerase I catalyses the ATP-independent breakage of single-stranded DNA, followed by passage and rejoining of another single-stranded DNA region. Relaxes negatively supercoiled DNA during replication, transcription and recombination events. YP_264949.1 Tryptophan biosynthesis YP_264950.1 Tryptophan biosynthesis YP_264952.1 Glutamate metabolism, Nitrogen metabolism YP_264954.1 The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini. YP_264957.1 Protein of unknown function DUF58 YP_264958.1 this may be a magnesium chelatase/ATPase that is involved in assembling the methanol dehydrogenase YP_264960.1 dual function sensor, contains a PAS-like sensory box to regulate the diguanylate cyclase and phosphodiesterase A domains YP_264961.1 Lysine degradation YP_264963.1 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis YP_264964.1 This family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNase enzyme. YP_264965.1 Binds single-stranded DNA and plays an important role in DNA replication, recombination and repair. YP_264967.1 UvrA orthologs are involved in the recognition of DNA damage as a step in nucleotide excision repair. YP_264974.1 Possible membrane protein: has 4 TM domains YP_264975.1 Glutathione metabolism, Glutamate metabolism YP_264977.1 N-acetyltransferase activity YP_264978.1 Protein of unknown function UPF0024 YP_264979.1 DNA-directed DNA polymerase activity YP_264981.1 possible enzymatic function YP_264982.1 Possible membrane protein YP_264984.1 Ubiquinone synthesis YP_264997.1 converts D-ribulose 5-phosphate into D-xylulose 5-phosphate in Calvin's reductive pentose phosphate cycle. YP_265005.1 Phosphorylation of GMP to GDP using ATP. YP_265008.1 Degradation of mRNA YP_265009.1 All proteins in this family for which functions are known are components of the primosome which is involved in replication, repair, and recombination. YP_265014.1 RecA plays a role in homologous recombination, DNA repair and induction of the SOS response. In homologous recombination, RecA functions as a DNA-dependent ATPase, promoting synapsis, heteroduplex formation and strand exchange between homologous DNAs. YP_265019.1 Folate synthesis YP_265034.1 Glutathione biosynthesis, Glutamate metabolism YP_265035.1 Pyrimidine biosynthesis YP_265039.1 peptidoglycan catabolism: N-acetylmuramoyl-L-alanine amidase activity YP_265040.1 mviN virulence genes are 12 TM spanning proteins related to the Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily YP_265050.1 Arginine biosynthesis, Metabolism of Amino groups. YP_265057.1 activates psp operon expression, see citation, possible leucine zipper for protein interaction 2 possible TM domains instead - possible receptor? YP_265059.1 possible oxidoreductase related to nitroreductase (COG3560) possible signal transduction protein involved in regulating fatty acid metabolism, see yeast genes YP_265060.1 Integrase, catalytic domain YP_265064.1 involved in secretion of heme-hemopexin utilization protein A YP_265070.1 Integrase, catalytic domain YP_265072.1 Essential for natural transformation and could be a transporter involved in DNA uptake. YP_265074.1 contains antisigma-factor antagonist (STAS) domain YP_265076.1 possible sulfide dehydrogenase (flavocytochrome c) due to one of the top blast hits, but this has no reference to back it up YP_265079.1 Responsible for directly reducing organic hyperoxides in its reduced dithiol form. YP_265099.1 motility YP_265109.1 involved in cytochrome c biogenesis YP_265110.1 involved in cytochrome c biogenesis YP_265111.1 involved in cytochrome c biogenesis YP_265113.1 possible histone deacetylase family protein YP_265115.1 Biosynthesis of pantothenate and CoA YP_265116.1 RadC plays a role in repair of DNA damage after UV and X-ray irradiation in prokaryotes. YP_265122.1 Nudix family:hydrolyse diverse nucleoside diphosphate derivatives. MutT:remove an oxidatively damaged form of guanine from DNA and the nucleotide pool YP_265123.1 hydrolyse diverse nucleoside diphosphate derivatives YP_265125.1 Adaptation to atypical conditions, specially when conditions cause growth arrest (ex. stationary phase) YP_265126.1 The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. YP_265128.1 antitermination YP_265139.1 Serine biosynthesis YP_265143.1 Catalyzes the last step of the biotin biosynthesis pathway YP_265145.1 Possible secreted protein due to the presence of a signal peptide YP_265150.1 Topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. YP_265155.1 Glutamate biosynthesis, Nitrogen metabolism YP_265156.1 Glutamate biosynthesis, Nitrogen metabolism YP_265158.1 Possible secreted protein, because it has a signal peptide present YP_265159.1 Phenylalanine, Tyrosine, Tryptophan Metabolism, Shikimate Pathway YP_265160.1 Phenylalanine, Tyrosine and Tryptophan metabolism YP_265161.1 forms outer membrane pore for protein secretion YP_265174.1 NusG is a bacterial transcriptional elongation factor involved in transcription termination and anti-termination YP_265182.1 Folate synthesis/Ubiquinone synthesis YP_265183.1 Histidine metabolism, Tyrosine metabolism, Phenylalanine metabolism and biosynthesis YP_265184.1 Histidine metabolism YP_265185.1 Histidine metabolism YP_265191.1 methyltransferase activity; enzyme specific to the cobalamin pathway and precorrin-2 is a common intermediate in the biosynthesis of corrinoids such as vitamin B12, siroheme and coenzyme F430 YP_265192.1 pentose phoshate pathway YP_265193.1 Thought to be responsible for Fe-S center assembly of nitrogenase YP_265194.1 degradation of aromatic compounds YP_265195.1 NAD+ Biosynthesis and metabolism YP_265196.1 First step in NAD salvage synthesis YP_265204.1 phosphate signalling YP_265205.1 phosphate signalling YP_265206.1 This homodimeric enzyme appears able to cleave any D-amino acid (and glycine, which does not have distinct D/L forms) from charged tRNA. The name reflects characterization with respect to D-Tyr on tRNA(Tyr) as established in the literature, but substrate YP_265207.1 Gly/Thr/Ser metabolism & glycerolipid metabolism YP_265213.1 predicted phosphohydrolase activity YP_265215.1 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. YP_265217.1 Isoprenoid biosynthesis YP_265218.1 The function of the DUF72 family is unknown. Aquifex aeolicus has two copies of this protein. A probable aspartyl-tRNA synthetase from Escherichia coli [1] belongs to this group YP_265221.1 protects the cell from HAP (base analog 6-N-hydroxylaminopurine), either on the level of deoxynucleoside triphosphate or the DNA level YP_265223.1 Endopeptidase Clp activity. Main role is degradation of proteins, peptides and glycopeptides YP_265226.1 gene regulator YP_265248.1 Biosynthesis of UMP from uridine YP_265255.1 Proteolytic enzyme. YP_265264.1 Required for excising and inserting mobile elements. YP_265265.1 MutY recognizes and excises the mutational intermediate 8-oxoguanine-adenine mispair. YP_265267.1 Possible role in transcription regulation, DNA repair, and/or DNA recombination. YP_265268.1 L-serine biosynthesis: Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor YP_265271.1 terminate transcription YP_265273.1 Proteolytic YP_265275.1 The exact function of these proteins is not yet clear but they are capable of wrapping DNA and stabilizing it from denaturation under extreme environmental conditions. YP_265280.1 Histidine biosynthesis YP_265288.1 MutT removes an oxidatively damaged form of guanine from DNA . Other family members hydrolyse diverse nucleoside diphosphate derivatives (including ADP-ribose, GDP- mannose, TDP-glucose, NADH, UDP-sugars, dNTP and NTP). YP_265289.1 Catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD YP_265292.1 Production of dTMP YP_265293.1 Folate biosynthesis YP_265294.1 This family consists of the DNA repair enzyme UvrC, an ABC excinuclease subunit which interacts with the UvrA/UvrB complex to excise UV-damaged nucleotide segments. YP_265301.1 two-component osmolarity sensor YP_265317.1 regulator of lacZ YP_265318.1 DksA is involved in translational regulation of RpoS. YP_265321.1 Peptidoglycan biosynthesis YP_265322.1 contains antisigma-factor antagonist (STAS) domain YP_265324.1 Nitrogen metabolism regulation, Glutamine biosynthesis YP_265328.1 Degradation of DNA and RNA YP_265346.1 Catalyses the removal of the ammonia group from glutamine and then to transfer this group to a substrate to form a new carbon-nitrogen group. YP_265348.1 Threonine biosynthesis YP_265349.1 Histidine biosynthesis YP_265350.1 Riboflavin synthesis YP_265351.1 regulation of rRNA biosynthesis by transcriptional antitermination. YP_265352.1 Thiamine pyrophosphate synthesis YP_265358.1 two-component sensor YP_265361.1 involved in thiamin (vitamin B1) synthesis YP_265367.1 for excising and inserting mobile element YP_265370.1 Arginine biosynthesis YP_265371.1 Involved in protein folding:accelerates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_265375.1 Topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. YP_265382.1 involved in the degradation of mRNA, and consequently have strong pleiotropic effects that may be difficult to disentangle. YP_265384.1 Histidine biosynthesis YP_265391.1 thiamine synthesis YP_265393.1 MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients YP_265394.1 catalytic activity:lipase,arylesterase,thermolabile hemolysin,phospholipase (AdRab-B),anter-specific proline-rich protein. YP_265399.1 Valine biosynthesis YP_265401.1 Histidine biosynthesis YP_265402.1 Histidine biosynthesis YP_265407.1 Heme synthesis YP_265411.1 Biotin synthesis YP_265413.1 Ability to bind unfolded protein substrates in an ATP-dependent manner YP_265414.1 In prokaryotes the grpE protein stimulates, jointly with dnaJ, the ATPase activity of the dnaK chaperone. It seems to accelerate the release of ADP from dnaK thus allowing dnaK to recycle more efficiently. YP_265416.1 involved in transformation with exogenous DNA YP_265418.1 Threonine biosynthesis, Vitamin B6 metabolism YP_265421.1 Riboflavin synthesis YP_265422.1 Riboflavin biosynthesis YP_265424.1 Involved in tRNA modification to create 5-methylaminomethyl-2-thiouridine in the wobble position of some tRNAs YP_265427.1 A site specific endonuclease that generates mature tRNAs by cleaving-off the leader sequences at their 5'ends.