-- dump date   	20140620_021102
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
357804000001	DDE superfamily endonuclease; Region: DDE_3; pfam13358
357804000002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
357804000003	Homeodomain-like domain; Region: HTH_23; pfam13384
357804000004	Winged helix-turn helix; Region: HTH_29; pfam13551
357804000005	Homeodomain-like domain; Region: HTH_32; pfam13565
357804000006	Winged helix-turn helix; Region: HTH_33; pfam13592
357804000007	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
357804000008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804000009	Walker A motif; other site
357804000010	ATP binding site [chemical binding]; other site
357804000011	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
357804000012	Walker B motif; other site
357804000013	arginine finger; other site
357804000014	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
357804000015	ATP-dependent protease subunit HslV; Provisional; Region: PRK05456
357804000016	Sporulation related domain; Region: SPOR; pfam05036
357804000017	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
357804000018	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
357804000019	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
357804000020	active site
357804000021	HIGH motif; other site
357804000022	KMSK motif region; other site
357804000023	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
357804000024	tRNA binding surface [nucleotide binding]; other site
357804000025	anticodon binding site; other site
357804000026	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
357804000027	Part of AAA domain; Region: AAA_19; pfam13245
357804000028	Family description; Region: UvrD_C_2; pfam13538
357804000029	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
357804000030	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
357804000031	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
357804000032	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
357804000033	active site
357804000034	Int/Topo IB signature motif; other site
357804000035	Protein of unknown function (DUF770); Region: DUF770; pfam05591
357804000036	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
357804000037	Protein of unknown function (DUF877); Region: DUF877; pfam05943
357804000038	Protein of unknown function (DUF796); Region: DUF796; cl01226
357804000039	Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405
357804000040	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522; cl01406
357804000041	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
357804000042	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
357804000043	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
357804000044	Protein of unknown function (DUF770); Region: DUF770; cl01402
357804000045	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
357804000046	Protein of unknown function (DUF877); Region: DUF877; pfam05943
357804000047	Protein of unknown function (DUF796); Region: DUF796; cl01226
357804000048	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
357804000049	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
357804000050	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
357804000051	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
357804000052	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
357804000053	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
357804000054	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
357804000055	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
357804000056	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000057	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
357804000058	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000059	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000060	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000061	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000062	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000063	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
357804000064	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000065	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000066	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000067	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000068	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000069	Protein of unknown function (DUF3540); Region: DUF3540; pfam12059
357804000070	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
357804000071	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
357804000072	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
357804000073	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
357804000074	Chitin-binding domain type 3; Region: ChtBD3; smart00495
357804000075	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
357804000076	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
357804000077	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000078	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000079	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000080	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
357804000081	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000082	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
357804000083	Protein of unknown function (DUF3540); Region: DUF3540; pfam12059
357804000084	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
357804000085	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
357804000086	dimerization interface [polypeptide binding]; other site
357804000087	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
357804000088	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804000089	Major Facilitator Superfamily; Region: MFS_1; pfam07690
357804000090	putative substrate translocation pore; other site
357804000091	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
357804000092	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
357804000093	ATP-grasp domain; Region: ATP-grasp_4; cl17255
357804000094	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
357804000095	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
357804000096	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
357804000097	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
357804000098	diaminopimelate decarboxylase; Region: lysA; TIGR01048
357804000099	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
357804000100	active site
357804000101	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
357804000102	substrate binding site [chemical binding]; other site
357804000103	catalytic residues [active]
357804000104	dimer interface [polypeptide binding]; other site
357804000105	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
357804000106	putative iron binding site [ion binding]; other site
357804000107	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
357804000108	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
357804000109	active site
357804000110	(T/H)XGH motif; other site
357804000111	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
357804000112	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
357804000113	putative NAD(P) binding site [chemical binding]; other site
357804000114	homotetramer interface [polypeptide binding]; other site
357804000115	homodimer interface [polypeptide binding]; other site
357804000116	active site
357804000117	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
357804000118	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804000119	DNA-binding site [nucleotide binding]; DNA binding site
357804000120	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
357804000121	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804000122	homodimer interface [polypeptide binding]; other site
357804000123	catalytic residue [active]
357804000124	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
357804000125	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804000126	substrate binding pocket [chemical binding]; other site
357804000127	membrane-bound complex binding site; other site
357804000128	hinge residues; other site
357804000129	ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525
357804000130	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
357804000131	Walker A/P-loop; other site
357804000132	ATP binding site [chemical binding]; other site
357804000133	Q-loop/lid; other site
357804000134	ABC transporter signature motif; other site
357804000135	Walker B; other site
357804000136	D-loop; other site
357804000137	H-loop/switch region; other site
357804000138	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
357804000139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804000140	dimer interface [polypeptide binding]; other site
357804000141	conserved gate region; other site
357804000142	putative PBP binding loops; other site
357804000143	ABC-ATPase subunit interface; other site
357804000144	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
357804000145	aminotransferase; Validated; Region: PRK07678
357804000146	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
357804000147	inhibitor-cofactor binding pocket; inhibition site
357804000148	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804000149	catalytic residue [active]
357804000150	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
357804000151	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
357804000152	DNA binding site [nucleotide binding]
357804000153	catalytic residue [active]
357804000154	H2TH interface [polypeptide binding]; other site
357804000155	putative catalytic residues [active]
357804000156	turnover-facilitating residue; other site
357804000157	intercalation triad [nucleotide binding]; other site
357804000158	8OG recognition residue [nucleotide binding]; other site
357804000159	putative reading head residues; other site
357804000160	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
357804000161	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
357804000162	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
357804000163	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
357804000164	hypothetical protein; Reviewed; Region: PRK00024
357804000165	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
357804000166	MPN+ (JAMM) motif; other site
357804000167	Zinc-binding site [ion binding]; other site
357804000168	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
357804000169	Flavoprotein; Region: Flavoprotein; pfam02441
357804000170	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
357804000171	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
357804000172	trimer interface [polypeptide binding]; other site
357804000173	active site
357804000174	division inhibitor protein; Provisional; Region: slmA; PRK09480
357804000175	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
357804000176	transcriptional repressor protein MetJ; Provisional; Region: PRK05264
357804000177	dimerization interface [polypeptide binding]; other site
357804000178	DNA binding site [nucleotide binding]
357804000179	corepressor binding sites; other site
357804000180	adenylate cyclase; Provisional; Region: cyaA; PRK09450
357804000181	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
357804000182	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
357804000183	putative global regulator; Reviewed; Region: PRK09559
357804000184	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
357804000185	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
357804000186	Uncharacterized conserved protein [Function unknown]; Region: COG2938
357804000187	L-aspartate oxidase; Provisional; Region: PRK09077
357804000188	L-aspartate oxidase; Provisional; Region: PRK06175
357804000189	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
357804000190	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
357804000191	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
357804000192	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
357804000193	DNA binding residues [nucleotide binding]
357804000194	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
357804000195	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
357804000196	anti-sigma E factor; Provisional; Region: rseB; PRK09455
357804000197	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
357804000198	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
357804000199	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
357804000200	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
357804000201	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
357804000202	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
357804000203	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
357804000204	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
357804000205	NAD(P) binding site [chemical binding]; other site
357804000206	shikimate binding site; other site
357804000207	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
357804000208	AIR carboxylase; Region: AIRC; pfam00731
357804000209	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
357804000210	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
357804000211	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
357804000212	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
357804000213	Protein of unknown function (DUF494); Region: DUF494; pfam04361
357804000214	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
357804000215	DNA protecting protein DprA; Region: dprA; TIGR00732
357804000216	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804000217	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
357804000218	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
357804000219	active site
357804000220	catalytic residues [active]
357804000221	metal binding site [ion binding]; metal-binding site
357804000222	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
357804000223	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
357804000224	putative active site [active]
357804000225	substrate binding site [chemical binding]; other site
357804000226	putative cosubstrate binding site; other site
357804000227	catalytic site [active]
357804000228	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
357804000229	substrate binding site [chemical binding]; other site
357804000230	16S rRNA methyltransferase B; Provisional; Region: PRK10901
357804000231	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
357804000232	putative RNA binding site [nucleotide binding]; other site
357804000233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804000234	S-adenosylmethionine binding site [chemical binding]; other site
357804000235	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
357804000236	TrkA-N domain; Region: TrkA_N; pfam02254
357804000237	TrkA-C domain; Region: TrkA_C; pfam02080
357804000238	TrkA-N domain; Region: TrkA_N; pfam02254
357804000239	TrkA-C domain; Region: TrkA_C; pfam02080
357804000240	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
357804000241	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
357804000242	RmuC family; Region: RmuC; pfam02646
357804000243	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
357804000244	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
357804000245	glutaminase active site [active]
357804000246	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
357804000247	dimer interface [polypeptide binding]; other site
357804000248	active site
357804000249	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
357804000250	dimer interface [polypeptide binding]; other site
357804000251	active site
357804000252	transaldolase-like protein; Provisional; Region: PTZ00411
357804000253	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
357804000254	active site
357804000255	dimer interface [polypeptide binding]; other site
357804000256	catalytic residue [active]
357804000257	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
357804000258	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
357804000259	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
357804000260	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
357804000261	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
357804000262	active site
357804000263	P-loop; other site
357804000264	phosphorylation site [posttranslational modification]
357804000265	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
357804000266	active site
357804000267	phosphorylation site [posttranslational modification]
357804000268	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
357804000269	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
357804000270	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
357804000271	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
357804000272	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
357804000273	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
357804000274	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
357804000275	putative ligand binding site [chemical binding]; other site
357804000276	putative NAD binding site [chemical binding]; other site
357804000277	catalytic site [active]
357804000278	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
357804000279	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
357804000280	active site
357804000281	substrate-binding site [chemical binding]; other site
357804000282	metal-binding site [ion binding]
357804000283	ATP binding site [chemical binding]; other site
357804000284	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
357804000285	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
357804000286	dimerization interface [polypeptide binding]; other site
357804000287	domain crossover interface; other site
357804000288	redox-dependent activation switch; other site
357804000289	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
357804000290	RNA binding surface [nucleotide binding]; other site
357804000291	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
357804000292	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
357804000293	type II secretion system protein D; Region: type_II_gspD; TIGR02517
357804000294	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
357804000295	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
357804000296	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
357804000297	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
357804000298	type II secretion system protein E; Region: type_II_gspE; TIGR02533
357804000299	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
357804000300	Walker A motif; other site
357804000301	ATP binding site [chemical binding]; other site
357804000302	Walker B motif; other site
357804000303	type II secretion system protein F; Region: GspF; TIGR02120
357804000304	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
357804000305	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
357804000306	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
357804000307	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
357804000308	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
357804000309	Type II transport protein GspH; Region: GspH; pfam12019
357804000310	type II secretion system protein I; Region: gspI; TIGR01707
357804000311	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
357804000312	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
357804000313	type II secretion system protein J; Region: gspJ; TIGR01711
357804000314	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
357804000315	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
357804000316	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
357804000317	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
357804000318	GspL periplasmic domain; Region: GspL_C; pfam12693
357804000319	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
357804000320	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
357804000321	LexA repressor; Validated; Region: PRK00215
357804000322	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
357804000323	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
357804000324	Catalytic site [active]
357804000325	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
357804000326	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
357804000327	Cu(I) binding site [ion binding]; other site
357804000328	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
357804000329	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
357804000330	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804000331	Coenzyme A binding pocket [chemical binding]; other site
357804000332	Homoserine O-succinyltransferase; Region: HTS; pfam04204
357804000333	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
357804000334	proposed active site lysine [active]
357804000335	conserved cys residue [active]
357804000336	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
357804000337	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
357804000338	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
357804000339	substrate binding pocket [chemical binding]; other site
357804000340	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
357804000341	B12 binding site [chemical binding]; other site
357804000342	cobalt ligand [ion binding]; other site
357804000343	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
357804000344	SWIM zinc finger; Region: SWIM; pfam04434
357804000345	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
357804000346	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804000347	ATP binding site [chemical binding]; other site
357804000348	putative Mg++ binding site [ion binding]; other site
357804000349	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804000350	nucleotide binding region [chemical binding]; other site
357804000351	ATP-binding site [chemical binding]; other site
357804000352	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
357804000353	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
357804000354	MOSC domain; Region: MOSC; pfam03473
357804000355	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
357804000356	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
357804000357	catalytic loop [active]
357804000358	iron binding site [ion binding]; other site
357804000359	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
357804000360	active site
357804000361	dimer interfaces [polypeptide binding]; other site
357804000362	catalytic residues [active]
357804000363	hypothetical protein; Provisional; Region: PRK11056
357804000364	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
357804000365	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
357804000366	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
357804000367	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
357804000368	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
357804000369	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
357804000370	dimer interface [polypeptide binding]; other site
357804000371	ADP-ribose binding site [chemical binding]; other site
357804000372	active site
357804000373	nudix motif; other site
357804000374	metal binding site [ion binding]; metal-binding site
357804000375	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
357804000376	Ligand Binding Site [chemical binding]; other site
357804000377	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
357804000378	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
357804000379	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
357804000380	active site
357804000381	intersubunit interface [polypeptide binding]; other site
357804000382	catalytic residue [active]
357804000383	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
357804000384	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
357804000385	substrate binding site [chemical binding]; other site
357804000386	ATP binding site [chemical binding]; other site
357804000387	Glucuronate isomerase; Region: UxaC; pfam02614
357804000388	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
357804000389	D-mannonate oxidoreductase; Provisional; Region: PRK15037
357804000390	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
357804000391	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
357804000392	DctM-like transporters; Region: DctM; pfam06808
357804000393	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
357804000394	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
357804000395	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
357804000396	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804000397	membrane-bound complex binding site; other site
357804000398	mannonate dehydratase; Provisional; Region: PRK03906
357804000399	mannonate dehydratase; Region: uxuA; TIGR00695
357804000400	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
357804000401	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804000402	DNA-binding site [nucleotide binding]; DNA binding site
357804000403	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
357804000404	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
357804000405	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
357804000406	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
357804000407	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
357804000408	Helix-turn-helix domain; Region: HTH_38; pfam13936
357804000409	Integrase core domain; Region: rve; pfam00665
357804000410	PAS fold; Region: PAS_3; pfam08447
357804000411	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804000412	putative active site [active]
357804000413	heme pocket [chemical binding]; other site
357804000414	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804000415	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804000416	metal binding site [ion binding]; metal-binding site
357804000417	active site
357804000418	I-site; other site
357804000419	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804000420	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
357804000421	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804000422	ATP binding site [chemical binding]; other site
357804000423	putative Mg++ binding site [ion binding]; other site
357804000424	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
357804000425	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
357804000426	non-specific DNA binding site [nucleotide binding]; other site
357804000427	salt bridge; other site
357804000428	sequence-specific DNA binding site [nucleotide binding]; other site
357804000429	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
357804000430	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
357804000431	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
357804000432	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
357804000433	DEAD-like helicases superfamily; Region: DEXDc; smart00487
357804000434	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804000435	ATP binding site [chemical binding]; other site
357804000436	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
357804000437	putative Mg++ binding site [ion binding]; other site
357804000438	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
357804000439	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
357804000440	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
357804000441	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804000442	motif II; other site
357804000443	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
357804000444	active site
357804000445	Int/Topo IB signature motif; other site
357804000446	DNA binding site [nucleotide binding]
357804000447	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
357804000448	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804000449	motif II; other site
357804000450	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
357804000451	Transglycosylase; Region: Transgly; pfam00912
357804000452	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
357804000453	Cell division protein FtsA; Region: FtsA; cl17206
357804000454	Competence protein A; Region: Competence_A; pfam11104
357804000455	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
357804000456	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
357804000457	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
357804000458	Pilus assembly protein, PilO; Region: PilO; pfam04350
357804000459	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
357804000460	Pilus assembly protein, PilP; Region: PilP; pfam04351
357804000461	AMIN domain; Region: AMIN; pfam11741
357804000462	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
357804000463	Secretin and TonB N terminus short domain; Region: STN; smart00965
357804000464	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
357804000465	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
357804000466	shikimate kinase; Reviewed; Region: aroK; PRK00131
357804000467	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
357804000468	ADP binding site [chemical binding]; other site
357804000469	magnesium binding site [ion binding]; other site
357804000470	putative shikimate binding site; other site
357804000471	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
357804000472	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
357804000473	active site
357804000474	dimer interface [polypeptide binding]; other site
357804000475	metal binding site [ion binding]; metal-binding site
357804000476	Sporulation related domain; Region: SPOR; pfam05036
357804000477	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
357804000478	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
357804000479	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
357804000480	substrate binding site [chemical binding]; other site
357804000481	hexamer interface [polypeptide binding]; other site
357804000482	metal binding site [ion binding]; metal-binding site
357804000483	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
357804000484	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
357804000485	active site
357804000486	HIGH motif; other site
357804000487	dimer interface [polypeptide binding]; other site
357804000488	KMSKS motif; other site
357804000489	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
357804000490	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
357804000491	dimer interface [polypeptide binding]; other site
357804000492	active site
357804000493	metal binding site [ion binding]; metal-binding site
357804000494	glutathione binding site [chemical binding]; other site
357804000495	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
357804000496	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
357804000497	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
357804000498	homooctamer interface [polypeptide binding]; other site
357804000499	active site
357804000500	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
357804000501	catalytic center binding site [active]
357804000502	ATP binding site [chemical binding]; other site
357804000503	Bacitracin resistance protein BacA; Region: BacA; pfam02673
357804000504	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
357804000505	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
357804000506	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
357804000507	active site
357804000508	NTP binding site [chemical binding]; other site
357804000509	metal binding triad [ion binding]; metal-binding site
357804000510	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
357804000511	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
357804000512	Zn2+ binding site [ion binding]; other site
357804000513	Mg2+ binding site [ion binding]; other site
357804000514	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
357804000515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804000516	Walker A motif; other site
357804000517	ATP binding site [chemical binding]; other site
357804000518	Walker B motif; other site
357804000519	arginine finger; other site
357804000520	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
357804000521	Bacterial SH3 domain homologues; Region: SH3b; smart00287
357804000522	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
357804000523	Protein of unknown function (DUF2031); Region: DUF2031; cl09810
357804000524	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
357804000525	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
357804000526	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
357804000527	Uncharacterized conserved protein [Function unknown]; Region: COG3025
357804000528	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
357804000529	putative active site [active]
357804000530	putative metal binding residues [ion binding]; other site
357804000531	signature motif; other site
357804000532	putative triphosphate binding site [ion binding]; other site
357804000533	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
357804000534	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
357804000535	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
357804000536	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
357804000537	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
357804000538	metal binding triad; other site
357804000539	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
357804000540	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
357804000541	metal binding triad; other site
357804000542	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
357804000543	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
357804000544	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
357804000545	putative acyl-acceptor binding pocket; other site
357804000546	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
357804000547	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
357804000548	acyl-activating enzyme (AAE) consensus motif; other site
357804000549	putative AMP binding site [chemical binding]; other site
357804000550	putative active site [active]
357804000551	putative CoA binding site [chemical binding]; other site
357804000552	O-succinylbenzoate synthase; Provisional; Region: PRK05105
357804000553	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
357804000554	active site
357804000555	alanine racemase; Reviewed; Region: alr; PRK00053
357804000556	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
357804000557	active site
357804000558	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
357804000559	substrate binding site [chemical binding]; other site
357804000560	catalytic residues [active]
357804000561	dimer interface [polypeptide binding]; other site
357804000562	replicative DNA helicase; Region: DnaB; TIGR00665
357804000563	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
357804000564	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
357804000565	Walker A motif; other site
357804000566	ATP binding site [chemical binding]; other site
357804000567	Walker B motif; other site
357804000568	DNA binding loops [nucleotide binding]
357804000569	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
357804000570	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
357804000571	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
357804000572	putative acyl-acceptor binding pocket; other site
357804000573	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
357804000574	active site residue [active]
357804000575	hypothetical protein; Provisional; Region: PRK11568
357804000576	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
357804000577	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
357804000578	Cation transport protein; Region: TrkH; cl17365
357804000579	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
357804000580	Flavodoxin domain; Region: Flavodoxin_5; cl17428
357804000581	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
357804000582	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804000583	ATP binding site [chemical binding]; other site
357804000584	putative Mg++ binding site [ion binding]; other site
357804000585	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804000586	nucleotide binding region [chemical binding]; other site
357804000587	ATP-binding site [chemical binding]; other site
357804000588	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
357804000589	HRDC domain; Region: HRDC; pfam00570
357804000590	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
357804000591	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
357804000592	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
357804000593	active site
357804000594	metal binding site [ion binding]; metal-binding site
357804000595	META domain; Region: META; pfam03724
357804000596	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
357804000597	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
357804000598	Zn2+ binding site [ion binding]; other site
357804000599	Mg2+ binding site [ion binding]; other site
357804000600	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
357804000601	synthetase active site [active]
357804000602	NTP binding site [chemical binding]; other site
357804000603	metal binding site [ion binding]; metal-binding site
357804000604	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
357804000605	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
357804000606	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
357804000607	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
357804000608	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
357804000609	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804000610	FeS/SAM binding site; other site
357804000611	HemN C-terminal domain; Region: HemN_C; pfam06969
357804000612	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
357804000613	Der GTPase activator (YihI); Region: YihI; pfam04220
357804000614	Cytochrome c553 [Energy production and conversion]; Region: COG2863
357804000615	Cytochrome c; Region: Cytochrom_C; cl11414
357804000616	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
357804000617	G1 box; other site
357804000618	GTP/Mg2+ binding site [chemical binding]; other site
357804000619	Switch I region; other site
357804000620	G2 box; other site
357804000621	G3 box; other site
357804000622	Switch II region; other site
357804000623	G4 box; other site
357804000624	G5 box; other site
357804000625	oligopeptidase A; Provisional; Region: PRK10911
357804000626	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
357804000627	active site
357804000628	Zn binding site [ion binding]; other site
357804000629	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
357804000630	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
357804000631	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
357804000632	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
357804000633	2-isopropylmalate synthase; Validated; Region: PRK00915
357804000634	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
357804000635	active site
357804000636	catalytic residues [active]
357804000637	metal binding site [ion binding]; metal-binding site
357804000638	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
357804000639	methionine sulfoxide reductase B; Provisional; Region: PRK00222
357804000640	SelR domain; Region: SelR; pfam01641
357804000641	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
357804000642	FAD binding domain; Region: FAD_binding_4; pfam01565
357804000643	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
357804000644	Biotin operon repressor [Transcription]; Region: BirA; COG1654
357804000645	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
357804000646	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
357804000647	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
357804000648	CHASE4 domain; Region: CHASE4; pfam05228
357804000649	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804000650	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804000651	metal binding site [ion binding]; metal-binding site
357804000652	active site
357804000653	I-site; other site
357804000654	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804000655	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
357804000656	short chain dehydrogenase; Provisional; Region: PRK07454
357804000657	classical (c) SDRs; Region: SDR_c; cd05233
357804000658	NAD(P) binding site [chemical binding]; other site
357804000659	active site
357804000660	xylulokinase; Provisional; Region: PRK15027
357804000661	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
357804000662	N- and C-terminal domain interface [polypeptide binding]; other site
357804000663	active site
357804000664	MgATP binding site [chemical binding]; other site
357804000665	catalytic site [active]
357804000666	metal binding site [ion binding]; metal-binding site
357804000667	xylulose binding site [chemical binding]; other site
357804000668	homodimer interface [polypeptide binding]; other site
357804000669	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
357804000670	CPxP  motif; other site
357804000671	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
357804000672	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
357804000673	acetylornithine deacetylase; Provisional; Region: PRK05111
357804000674	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
357804000675	metal binding site [ion binding]; metal-binding site
357804000676	putative dimer interface [polypeptide binding]; other site
357804000677	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
357804000678	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
357804000679	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
357804000680	nucleotide binding site [chemical binding]; other site
357804000681	substrate binding site [chemical binding]; other site
357804000682	ornithine carbamoyltransferase; Provisional; Region: PRK14805
357804000683	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
357804000684	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
357804000685	argininosuccinate synthase; Provisional; Region: PRK13820
357804000686	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
357804000687	ANP binding site [chemical binding]; other site
357804000688	Substrate Binding Site II [chemical binding]; other site
357804000689	Substrate Binding Site I [chemical binding]; other site
357804000690	bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308
357804000691	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
357804000692	active sites [active]
357804000693	tetramer interface [polypeptide binding]; other site
357804000694	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804000695	Coenzyme A binding pocket [chemical binding]; other site
357804000696	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
357804000697	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
357804000698	trimer interface [polypeptide binding]; other site
357804000699	putative metal binding site [ion binding]; other site
357804000700	integrase; Provisional; Region: PRK09692
357804000701	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
357804000702	active site
357804000703	Int/Topo IB signature motif; other site
357804000704	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
357804000705	Protein of unknown function (DUF511); Region: DUF511; pfam04373
357804000706	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
357804000707	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
357804000708	Transposase; Region: DEDD_Tnp_IS110; pfam01548
357804000709	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
357804000710	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
357804000711	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
357804000712	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
357804000713	multiple promoter invertase; Provisional; Region: mpi; PRK13413
357804000714	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
357804000715	catalytic residues [active]
357804000716	catalytic nucleophile [active]
357804000717	Presynaptic Site I dimer interface [polypeptide binding]; other site
357804000718	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
357804000719	Synaptic Flat tetramer interface [polypeptide binding]; other site
357804000720	Synaptic Site I dimer interface [polypeptide binding]; other site
357804000721	DNA binding site [nucleotide binding]
357804000722	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
357804000723	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
357804000724	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
357804000725	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
357804000726	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
357804000727	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
357804000728	Interdomain contacts; other site
357804000729	Cytokine receptor motif; other site
357804000730	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
357804000731	Interdomain contacts; other site
357804000732	Cytokine receptor motif; other site
357804000733	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
357804000734	Interdomain contacts; other site
357804000735	Cytokine receptor motif; other site
357804000736	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
357804000737	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
357804000738	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
357804000739	catalytic core [active]
357804000740	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
357804000741	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804000742	Coenzyme A binding pocket [chemical binding]; other site
357804000743	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
357804000744	TAP-like protein; Region: Abhydrolase_4; pfam08386
357804000745	Methyltransferase domain; Region: Methyltransf_31; pfam13847
357804000746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804000747	S-adenosylmethionine binding site [chemical binding]; other site
357804000748	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
357804000749	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
357804000750	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
357804000751	malonyl-CoA binding site [chemical binding]; other site
357804000752	dimer interface [polypeptide binding]; other site
357804000753	active site
357804000754	product binding site; other site
357804000755	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
357804000756	Acyltransferase family; Region: Acyl_transf_3; pfam01757
357804000757	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
357804000758	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804000759	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804000760	metal binding site [ion binding]; metal-binding site
357804000761	active site
357804000762	I-site; other site
357804000763	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
357804000764	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
357804000765	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
357804000766	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
357804000767	Na binding site [ion binding]; other site
357804000768	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
357804000769	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
357804000770	ligand binding site [chemical binding]; other site
357804000771	flexible hinge region; other site
357804000772	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
357804000773	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
357804000774	metal binding triad; other site
357804000775	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
357804000776	active site
357804000777	catalytic site [active]
357804000778	substrate binding site [chemical binding]; other site
357804000779	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
357804000780	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
357804000781	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
357804000782	putative active site [active]
357804000783	Zn binding site [ion binding]; other site
357804000784	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
357804000785	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
357804000786	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
357804000787	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
357804000788	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
357804000789	Flavodoxin; Region: Flavodoxin_1; pfam00258
357804000790	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide.  Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201
357804000791	FAD binding pocket [chemical binding]; other site
357804000792	FAD binding motif [chemical binding]; other site
357804000793	catalytic residues [active]
357804000794	NAD binding pocket [chemical binding]; other site
357804000795	phosphate binding motif [ion binding]; other site
357804000796	beta-alpha-beta structure motif; other site
357804000797	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
357804000798	dimerization interface [polypeptide binding]; other site
357804000799	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804000800	PAS fold; Region: PAS_3; pfam08447
357804000801	putative active site [active]
357804000802	heme pocket [chemical binding]; other site
357804000803	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804000804	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804000805	putative active site [active]
357804000806	heme pocket [chemical binding]; other site
357804000807	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804000808	putative active site [active]
357804000809	heme pocket [chemical binding]; other site
357804000810	PAS domain S-box; Region: sensory_box; TIGR00229
357804000811	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804000812	putative active site [active]
357804000813	heme pocket [chemical binding]; other site
357804000814	PAS domain S-box; Region: sensory_box; TIGR00229
357804000815	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804000816	putative active site [active]
357804000817	heme pocket [chemical binding]; other site
357804000818	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804000819	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804000820	metal binding site [ion binding]; metal-binding site
357804000821	active site
357804000822	I-site; other site
357804000823	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
357804000824	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
357804000825	DNA binding residues [nucleotide binding]
357804000826	Helix-turn-helix domain; Region: HTH_18; pfam12833
357804000827	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
357804000828	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
357804000829	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
357804000830	ethanolamine permease; Region: 2A0305; TIGR00908
357804000831	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804000832	DNA-binding site [nucleotide binding]; DNA binding site
357804000833	RNA-binding motif; other site
357804000834	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
357804000835	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
357804000836	ligand binding site [chemical binding]; other site
357804000837	sensor protein PhoQ; Provisional; Region: PRK10815
357804000838	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804000839	ATP binding site [chemical binding]; other site
357804000840	Mg2+ binding site [ion binding]; other site
357804000841	G-X-G motif; other site
357804000842	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
357804000843	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804000844	active site
357804000845	phosphorylation site [posttranslational modification]
357804000846	intermolecular recognition site; other site
357804000847	dimerization interface [polypeptide binding]; other site
357804000848	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
357804000849	DNA binding site [nucleotide binding]
357804000850	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
357804000851	selenophosphate synthetase; Provisional; Region: PRK00943
357804000852	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
357804000853	dimerization interface [polypeptide binding]; other site
357804000854	putative ATP binding site [chemical binding]; other site
357804000855	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
357804000856	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
357804000857	active site residue [active]
357804000858	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
357804000859	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
357804000860	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
357804000861	Chorismate mutase type II; Region: CM_2; cl00693
357804000862	prephenate dehydrogenase; Validated; Region: PRK08507
357804000863	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
357804000864	30S subunit binding site; other site
357804000865	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
357804000866	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
357804000867	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
357804000868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804000869	dimer interface [polypeptide binding]; other site
357804000870	conserved gate region; other site
357804000871	putative PBP binding loops; other site
357804000872	ABC-ATPase subunit interface; other site
357804000873	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
357804000874	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804000875	dimer interface [polypeptide binding]; other site
357804000876	conserved gate region; other site
357804000877	putative PBP binding loops; other site
357804000878	ABC-ATPase subunit interface; other site
357804000879	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
357804000880	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804000881	Walker A/P-loop; other site
357804000882	ATP binding site [chemical binding]; other site
357804000883	Q-loop/lid; other site
357804000884	ABC transporter signature motif; other site
357804000885	Walker B; other site
357804000886	D-loop; other site
357804000887	H-loop/switch region; other site
357804000888	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
357804000889	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804000890	Walker A/P-loop; other site
357804000891	ATP binding site [chemical binding]; other site
357804000892	Q-loop/lid; other site
357804000893	ABC transporter signature motif; other site
357804000894	Walker B; other site
357804000895	D-loop; other site
357804000896	H-loop/switch region; other site
357804000897	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
357804000898	lytic murein transglycosylase; Provisional; Region: PRK11619
357804000899	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
357804000900	N-acetyl-D-glucosamine binding site [chemical binding]; other site
357804000901	catalytic residue [active]
357804000902	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
357804000903	arginine repressor; Provisional; Region: PRK05066
357804000904	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
357804000905	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
357804000906	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804000907	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
357804000908	substrate binding pocket [chemical binding]; other site
357804000909	membrane-bound complex binding site; other site
357804000910	hinge residues; other site
357804000911	malate dehydrogenase; Provisional; Region: PRK05086
357804000912	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
357804000913	NAD binding site [chemical binding]; other site
357804000914	dimerization interface [polypeptide binding]; other site
357804000915	Substrate binding site [chemical binding]; other site
357804000916	siroheme synthase; Provisional; Region: cysG; PRK10637
357804000917	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
357804000918	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
357804000919	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
357804000920	active site
357804000921	SAM binding site [chemical binding]; other site
357804000922	homodimer interface [polypeptide binding]; other site
357804000923	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
357804000924	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
357804000925	ligand binding site; other site
357804000926	oligomer interface; other site
357804000927	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
357804000928	dimer interface [polypeptide binding]; other site
357804000929	N-terminal domain interface [polypeptide binding]; other site
357804000930	sulfate 1 binding site; other site
357804000931	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
357804000932	Proline dehydrogenase; Region: Pro_dh; pfam01619
357804000933	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
357804000934	Glutamate binding site [chemical binding]; other site
357804000935	NAD binding site [chemical binding]; other site
357804000936	catalytic residues [active]
357804000937	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
357804000938	NAD(P) binding site [chemical binding]; other site
357804000939	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
357804000940	CoenzymeA binding site [chemical binding]; other site
357804000941	subunit interaction site [polypeptide binding]; other site
357804000942	PHB binding site; other site
357804000943	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
357804000944	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
357804000945	non-specific DNA binding site [nucleotide binding]; other site
357804000946	salt bridge; other site
357804000947	sequence-specific DNA binding site [nucleotide binding]; other site
357804000948	Protein of unknown function (DUF3612); Region: DUF3612; pfam12268
357804000949	malate synthase G; Provisional; Region: PRK02999
357804000950	active site
357804000951	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
357804000952	tetramer interface [polypeptide binding]; other site
357804000953	active site
357804000954	Mg2+/Mn2+ binding site [ion binding]; other site
357804000955	isocitrate lyase; Region: PLN02892
357804000956	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
357804000957	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
357804000958	active site
357804000959	catalytic site [active]
357804000960	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
357804000961	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
357804000962	Zn2+ binding site [ion binding]; other site
357804000963	Mg2+ binding site [ion binding]; other site
357804000964	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
357804000965	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
357804000966	Predicted membrane protein [Function unknown]; Region: COG3205
357804000967	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
357804000968	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
357804000969	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
357804000970	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
357804000971	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
357804000972	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
357804000973	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
357804000974	DNA binding residues [nucleotide binding]
357804000975	DNA primase; Validated; Region: dnaG; PRK05667
357804000976	CHC2 zinc finger; Region: zf-CHC2; pfam01807
357804000977	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
357804000978	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
357804000979	active site
357804000980	metal binding site [ion binding]; metal-binding site
357804000981	interdomain interaction site; other site
357804000982	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
357804000983	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
357804000984	Yqey-like protein; Region: YqeY; pfam09424
357804000985	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
357804000986	UGMP family protein; Validated; Region: PRK09604
357804000987	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
357804000988	LPS O-antigen length regulator; Provisional; Region: PRK10381
357804000989	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
357804000990	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
357804000991	dimer interface [polypeptide binding]; other site
357804000992	allosteric magnesium binding site [ion binding]; other site
357804000993	active site
357804000994	aspartate-rich active site metal binding site; other site
357804000995	Schiff base residues; other site
357804000996	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
357804000997	active site
357804000998	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
357804000999	sec-independent translocase; Provisional; Region: PRK01770
357804001000	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
357804001001	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
357804001002	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
357804001003	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
357804001004	SCP-2 sterol transfer family; Region: SCP2; pfam02036
357804001005	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
357804001006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804001007	S-adenosylmethionine binding site [chemical binding]; other site
357804001008	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
357804001009	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
357804001010	active site
357804001011	dimer interface [polypeptide binding]; other site
357804001012	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
357804001013	dimer interface [polypeptide binding]; other site
357804001014	active site
357804001015	Domain of unknown function (DUF1919); Region: DUF1919; pfam08942
357804001016	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
357804001017	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
357804001018	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
357804001019	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
357804001020	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
357804001021	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
357804001022	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
357804001023	putative metal binding site; other site
357804001024	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
357804001025	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
357804001026	putative active site [active]
357804001027	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
357804001028	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
357804001029	active site
357804001030	ATP binding site [chemical binding]; other site
357804001031	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
357804001032	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
357804001033	Substrate binding site; other site
357804001034	metal-binding site
357804001035	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
357804001036	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
357804001037	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
357804001038	O-Antigen ligase; Region: Wzy_C; pfam04932
357804001039	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
357804001040	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
357804001041	putative active site [active]
357804001042	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
357804001043	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
357804001044	NADP binding site [chemical binding]; other site
357804001045	homopentamer interface [polypeptide binding]; other site
357804001046	substrate binding site [chemical binding]; other site
357804001047	active site
357804001048	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
357804001049	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
357804001050	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
357804001051	active site residue [active]
357804001052	transketolase; Reviewed; Region: PRK12753
357804001053	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
357804001054	TPP-binding site [chemical binding]; other site
357804001055	dimer interface [polypeptide binding]; other site
357804001056	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
357804001057	PYR/PP interface [polypeptide binding]; other site
357804001058	dimer interface [polypeptide binding]; other site
357804001059	TPP binding site [chemical binding]; other site
357804001060	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
357804001061	D-ribose pyranase; Provisional; Region: PRK11797
357804001062	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
357804001063	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
357804001064	Walker A/P-loop; other site
357804001065	ATP binding site [chemical binding]; other site
357804001066	Q-loop/lid; other site
357804001067	ABC transporter signature motif; other site
357804001068	Walker B; other site
357804001069	D-loop; other site
357804001070	H-loop/switch region; other site
357804001071	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
357804001072	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
357804001073	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
357804001074	TM-ABC transporter signature motif; other site
357804001075	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
357804001076	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
357804001077	ligand binding site [chemical binding]; other site
357804001078	dimerization interface [polypeptide binding]; other site
357804001079	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
357804001080	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
357804001081	substrate binding site [chemical binding]; other site
357804001082	dimer interface [polypeptide binding]; other site
357804001083	ATP binding site [chemical binding]; other site
357804001084	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
357804001085	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804001086	DNA binding site [nucleotide binding]
357804001087	domain linker motif; other site
357804001088	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
357804001089	dimerization interface [polypeptide binding]; other site
357804001090	ligand binding site [chemical binding]; other site
357804001091	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
357804001092	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
357804001093	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
357804001094	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
357804001095	PYR/PP interface [polypeptide binding]; other site
357804001096	dimer interface [polypeptide binding]; other site
357804001097	TPP binding site [chemical binding]; other site
357804001098	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
357804001099	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
357804001100	TPP-binding site [chemical binding]; other site
357804001101	dimer interface [polypeptide binding]; other site
357804001102	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
357804001103	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
357804001104	substrate binding site [chemical binding]; other site
357804001105	oxyanion hole (OAH) forming residues; other site
357804001106	trimer interface [polypeptide binding]; other site
357804001107	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
357804001108	Putative serine esterase (DUF676); Region: DUF676; pfam05057
357804001109	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
357804001110	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
357804001111	dimer interface [polypeptide binding]; other site
357804001112	tetramer interface [polypeptide binding]; other site
357804001113	PYR/PP interface [polypeptide binding]; other site
357804001114	TPP binding site [chemical binding]; other site
357804001115	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
357804001116	TPP-binding site; other site
357804001117	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
357804001118	chorismate binding enzyme; Region: Chorismate_bind; cl10555
357804001119	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
357804001120	UbiA prenyltransferase family; Region: UbiA; pfam01040
357804001121	elongation factor G; Reviewed; Region: PRK00007
357804001122	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
357804001123	G1 box; other site
357804001124	putative GEF interaction site [polypeptide binding]; other site
357804001125	GTP/Mg2+ binding site [chemical binding]; other site
357804001126	Switch I region; other site
357804001127	G2 box; other site
357804001128	G3 box; other site
357804001129	Switch II region; other site
357804001130	G4 box; other site
357804001131	G5 box; other site
357804001132	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
357804001133	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
357804001134	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
357804001135	Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785
357804001136	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
357804001137	ThiC-associated domain; Region: ThiC-associated; pfam13667
357804001138	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
357804001139	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
357804001140	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
357804001141	substrate binding site [chemical binding]; other site
357804001142	dimer interface [polypeptide binding]; other site
357804001143	ATP binding site [chemical binding]; other site
357804001144	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
357804001145	thiamine phosphate binding site [chemical binding]; other site
357804001146	active site
357804001147	pyrophosphate binding site [ion binding]; other site
357804001148	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
357804001149	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
357804001150	ATP binding site [chemical binding]; other site
357804001151	substrate interface [chemical binding]; other site
357804001152	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
357804001153	thiS-thiF/thiG interaction site; other site
357804001154	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
357804001155	ThiS interaction site; other site
357804001156	putative active site [active]
357804001157	tetramer interface [polypeptide binding]; other site
357804001158	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
357804001159	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804001160	FeS/SAM binding site; other site
357804001161	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
357804001162	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
357804001163	RNA binding surface [nucleotide binding]; other site
357804001164	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
357804001165	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
357804001166	N-acetyl-D-glucosamine binding site [chemical binding]; other site
357804001167	catalytic residue [active]
357804001168	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
357804001169	O-Antigen ligase; Region: Wzy_C; pfam04932
357804001170	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
357804001171	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
357804001172	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
357804001173	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
357804001174	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
357804001175	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
357804001176	Phosphoglycerate kinase; Region: PGK; pfam00162
357804001177	substrate binding site [chemical binding]; other site
357804001178	hinge regions; other site
357804001179	ADP binding site [chemical binding]; other site
357804001180	catalytic site [active]
357804001181	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
357804001182	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
357804001183	active site
357804001184	intersubunit interface [polypeptide binding]; other site
357804001185	zinc binding site [ion binding]; other site
357804001186	Na+ binding site [ion binding]; other site
357804001187	Uncharacterized conserved protein [Function unknown]; Region: COG2968
357804001188	Protein of unknown function (DUF541); Region: SIMPL; cl01077
357804001189	Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253
357804001190	oxidative damage protection protein; Provisional; Region: PRK05408
357804001191	adenine DNA glycosylase; Provisional; Region: PRK10880
357804001192	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
357804001193	minor groove reading motif; other site
357804001194	helix-hairpin-helix signature motif; other site
357804001195	substrate binding pocket [chemical binding]; other site
357804001196	active site
357804001197	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
357804001198	DNA binding and oxoG recognition site [nucleotide binding]
357804001199	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
357804001200	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
357804001201	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
357804001202	putative metal binding site [ion binding]; other site
357804001203	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
357804001204	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
357804001205	hypothetical protein; Provisional; Region: PRK00967
357804001206	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
357804001207	EamA-like transporter family; Region: EamA; pfam00892
357804001208	EamA-like transporter family; Region: EamA; pfam00892
357804001209	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
357804001210	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
357804001211	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
357804001212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804001213	dimer interface [polypeptide binding]; other site
357804001214	putative PBP binding loops; other site
357804001215	ABC-ATPase subunit interface; other site
357804001216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804001217	dimer interface [polypeptide binding]; other site
357804001218	conserved gate region; other site
357804001219	putative PBP binding loops; other site
357804001220	ABC-ATPase subunit interface; other site
357804001221	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
357804001222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804001223	Walker A/P-loop; other site
357804001224	ATP binding site [chemical binding]; other site
357804001225	Q-loop/lid; other site
357804001226	ABC transporter signature motif; other site
357804001227	Walker B; other site
357804001228	D-loop; other site
357804001229	H-loop/switch region; other site
357804001230	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
357804001231	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
357804001232	ligand binding site [chemical binding]; other site
357804001233	flexible hinge region; other site
357804001234	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
357804001235	putative switch regulator; other site
357804001236	non-specific DNA interactions [nucleotide binding]; other site
357804001237	DNA binding site [nucleotide binding]
357804001238	sequence specific DNA binding site [nucleotide binding]; other site
357804001239	putative cAMP binding site [chemical binding]; other site
357804001240	Uncharacterized protein family (UPF0270); Region: UPF0270; pfam06794
357804001241	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
357804001242	active site clefts [active]
357804001243	zinc binding site [ion binding]; other site
357804001244	dimer interface [polypeptide binding]; other site
357804001245	Cytochrome c; Region: Cytochrom_C; cl11414
357804001246	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
357804001247	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
357804001248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804001249	Walker A motif; other site
357804001250	ATP binding site [chemical binding]; other site
357804001251	Walker B motif; other site
357804001252	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
357804001253	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
357804001254	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
357804001255	HIGH motif; other site
357804001256	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
357804001257	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
357804001258	active site
357804001259	KMSKS motif; other site
357804001260	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
357804001261	tRNA binding surface [nucleotide binding]; other site
357804001262	anticodon binding site; other site
357804001263	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
357804001264	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
357804001265	multifunctional aminopeptidase A; Provisional; Region: PRK00913
357804001266	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
357804001267	interface (dimer of trimers) [polypeptide binding]; other site
357804001268	Substrate-binding/catalytic site; other site
357804001269	Zn-binding sites [ion binding]; other site
357804001270	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
357804001271	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
357804001272	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
357804001273	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
357804001274	RDD family; Region: RDD; pfam06271
357804001275	integrase; Provisional; Region: int; PHA02601
357804001276	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
357804001277	active site
357804001278	DNA binding site [nucleotide binding]
357804001279	Int/Topo IB signature motif; other site
357804001280	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
357804001281	Virulence-associated protein E; Region: VirE; pfam05272
357804001282	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
357804001283	putative DNA binding site [nucleotide binding]; other site
357804001284	putative Zn2+ binding site [ion binding]; other site
357804001285	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
357804001286	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
357804001287	active site
357804001288	DNA binding site [nucleotide binding]
357804001289	Int/Topo IB signature motif; other site
357804001290	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
357804001291	PGAP1-like protein; Region: PGAP1; pfam07819
357804001292	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
357804001293	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
357804001294	Walker A/P-loop; other site
357804001295	ATP binding site [chemical binding]; other site
357804001296	Q-loop/lid; other site
357804001297	ABC transporter signature motif; other site
357804001298	Walker B; other site
357804001299	D-loop; other site
357804001300	H-loop/switch region; other site
357804001301	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
357804001302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804001303	dimer interface [polypeptide binding]; other site
357804001304	conserved gate region; other site
357804001305	putative PBP binding loops; other site
357804001306	ABC-ATPase subunit interface; other site
357804001307	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
357804001308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804001309	dimer interface [polypeptide binding]; other site
357804001310	conserved gate region; other site
357804001311	putative PBP binding loops; other site
357804001312	ABC-ATPase subunit interface; other site
357804001313	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
357804001314	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804001315	substrate binding pocket [chemical binding]; other site
357804001316	membrane-bound complex binding site; other site
357804001317	hinge residues; other site
357804001318	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
357804001319	homotrimer interaction site [polypeptide binding]; other site
357804001320	putative active site [active]
357804001321	Amidase; Region: Amidase; cl11426
357804001322	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804001323	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804001324	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804001325	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
357804001326	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u8; cd10932
357804001327	NodB motif; other site
357804001328	putative active site [active]
357804001329	putative catalytic site [active]
357804001330	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
357804001331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
357804001332	binding surface
357804001333	TPR motif; other site
357804001334	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
357804001335	TPR motif; other site
357804001336	binding surface
357804001337	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804001338	binding surface
357804001339	TPR motif; other site
357804001340	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804001341	binding surface
357804001342	TPR motif; other site
357804001343	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
357804001344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804001345	active site
357804001346	phosphorylation site [posttranslational modification]
357804001347	intermolecular recognition site; other site
357804001348	dimerization interface [polypeptide binding]; other site
357804001349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804001350	Walker A motif; other site
357804001351	ATP binding site [chemical binding]; other site
357804001352	Walker B motif; other site
357804001353	arginine finger; other site
357804001354	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
357804001355	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
357804001356	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
357804001357	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
357804001358	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
357804001359	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
357804001360	SLBB domain; Region: SLBB; pfam10531
357804001361	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
357804001362	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804001363	ATP binding site [chemical binding]; other site
357804001364	Mg2+ binding site [ion binding]; other site
357804001365	G-X-G motif; other site
357804001366	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
357804001367	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
357804001368	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
357804001369	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
357804001370	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
357804001371	active site
357804001372	homodimer interface [polypeptide binding]; other site
357804001373	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
357804001374	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
357804001375	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
357804001376	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
357804001377	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
357804001378	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
357804001379	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
357804001380	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
357804001381	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
357804001382	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
357804001383	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
357804001384	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
357804001385	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
357804001386	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
357804001387	acyl-activating enzyme (AAE) consensus motif; other site
357804001388	active site
357804001389	AMP binding site [chemical binding]; other site
357804001390	CoA binding site [chemical binding]; other site
357804001391	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
357804001392	O-Antigen ligase; Region: Wzy_C; pfam04932
357804001393	Acyltransferase family; Region: Acyl_transf_3; pfam01757
357804001394	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
357804001395	Ligand binding site; other site
357804001396	Putative Catalytic site; other site
357804001397	DXD motif; other site
357804001398	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
357804001399	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
357804001400	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
357804001401	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
357804001402	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
357804001403	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804001404	NAD(P) binding site [chemical binding]; other site
357804001405	active site
357804001406	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
357804001407	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
357804001408	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
357804001409	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
357804001410	putative active site [active]
357804001411	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
357804001412	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
357804001413	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
357804001414	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
357804001415	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
357804001416	Interdomain contacts; other site
357804001417	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
357804001418	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
357804001419	Bacterial sugar transferase; Region: Bac_transf; pfam02397
357804001420	alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305
357804001421	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
357804001422	alpha subunit interaction interface [polypeptide binding]; other site
357804001423	Walker A motif; other site
357804001424	ATP binding site [chemical binding]; other site
357804001425	Walker B motif; other site
357804001426	inhibitor binding site; inhibition site
357804001427	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
357804001428	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
357804001429	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
357804001430	gamma subunit interface [polypeptide binding]; other site
357804001431	epsilon subunit interface [polypeptide binding]; other site
357804001432	LBP interface [polypeptide binding]; other site
357804001433	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
357804001434	N-ATPase, AtpR subunit; Region: AtpR; pfam12966
357804001435	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
357804001436	alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306
357804001437	F0F1 ATP synthase subunit C; Provisional; Region: PRK13468
357804001438	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
357804001439	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
357804001440	alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324
357804001441	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
357804001442	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
357804001443	Walker A motif; other site
357804001444	ATP binding site [chemical binding]; other site
357804001445	Walker B motif; other site
357804001446	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
357804001447	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
357804001448	core domain interface [polypeptide binding]; other site
357804001449	delta subunit interface [polypeptide binding]; other site
357804001450	epsilon subunit interface [polypeptide binding]; other site
357804001451	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
357804001452	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
357804001453	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804001454	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
357804001455	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
357804001456	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
357804001457	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
357804001458	Pilin (bacterial filament); Region: Pilin; pfam00114
357804001459	putative major pilin subunit; Provisional; Region: PRK10574
357804001460	putative major pilin subunit; Provisional; Region: PRK10574
357804001461	putative major pilin subunit; Provisional; Region: PRK10574
357804001462	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
357804001463	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
357804001464	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
357804001465	Walker A motif; other site
357804001466	ATP binding site [chemical binding]; other site
357804001467	Walker B motif; other site
357804001468	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
357804001469	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
357804001470	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
357804001471	Response regulator receiver domain; Region: Response_reg; pfam00072
357804001472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804001473	active site
357804001474	phosphorylation site [posttranslational modification]
357804001475	intermolecular recognition site; other site
357804001476	dimerization interface [polypeptide binding]; other site
357804001477	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804001478	CHASE domain; Region: CHASE; pfam03924
357804001479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804001480	PAS fold; Region: PAS_3; pfam08447
357804001481	putative active site [active]
357804001482	heme pocket [chemical binding]; other site
357804001483	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
357804001484	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804001485	putative active site [active]
357804001486	heme pocket [chemical binding]; other site
357804001487	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804001488	dimer interface [polypeptide binding]; other site
357804001489	phosphorylation site [posttranslational modification]
357804001490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804001491	ATP binding site [chemical binding]; other site
357804001492	Mg2+ binding site [ion binding]; other site
357804001493	G-X-G motif; other site
357804001494	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
357804001495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804001496	active site
357804001497	phosphorylation site [posttranslational modification]
357804001498	intermolecular recognition site; other site
357804001499	dimerization interface [polypeptide binding]; other site
357804001500	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
357804001501	putative binding surface; other site
357804001502	active site
357804001503	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
357804001504	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
357804001505	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
357804001506	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
357804001507	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
357804001508	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
357804001509	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
357804001510	active site
357804001511	dimer interface [polypeptide binding]; other site
357804001512	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
357804001513	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
357804001514	active site
357804001515	trimer interface [polypeptide binding]; other site
357804001516	allosteric site; other site
357804001517	active site lid [active]
357804001518	hexamer (dimer of trimers) interface [polypeptide binding]; other site
357804001519	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
357804001520	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
357804001521	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
357804001522	active site turn [active]
357804001523	phosphorylation site [posttranslational modification]
357804001524	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
357804001525	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
357804001526	active site
357804001527	HIGH motif; other site
357804001528	nucleotide binding site [chemical binding]; other site
357804001529	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
357804001530	KMSKS motif; other site
357804001531	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
357804001532	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
357804001533	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
357804001534	Walker A motif; other site
357804001535	ATP binding site [chemical binding]; other site
357804001536	Walker B motif; other site
357804001537	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
357804001538	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
357804001539	active site
357804001540	catalytic site [active]
357804001541	substrate binding site [chemical binding]; other site
357804001542	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
357804001543	RNA/DNA hybrid binding site [nucleotide binding]; other site
357804001544	active site
357804001545	Methyltransferase domain; Region: Methyltransf_11; pfam08241
357804001546	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
357804001547	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
357804001548	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
357804001549	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
357804001550	N-acetyl-D-glucosamine binding site [chemical binding]; other site
357804001551	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804001552	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804001553	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
357804001554	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804001555	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
357804001556	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
357804001557	putative DNA-binding cleft [nucleotide binding]; other site
357804001558	putative DNA clevage site; other site
357804001559	molecular lever; other site
357804001560	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
357804001561	putative active site [active]
357804001562	Ap4A binding site [chemical binding]; other site
357804001563	nudix motif; other site
357804001564	putative metal binding site [ion binding]; other site
357804001565	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
357804001566	GAF domain; Region: GAF; pfam01590
357804001567	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
357804001568	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
357804001569	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
357804001570	serine/threonine transporter SstT; Provisional; Region: PRK13628
357804001571	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
357804001572	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
357804001573	thymidylate synthase; Reviewed; Region: thyA; PRK01827
357804001574	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
357804001575	dimerization interface [polypeptide binding]; other site
357804001576	active site
357804001577	glutathione reductase; Validated; Region: PRK06116
357804001578	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
357804001579	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
357804001580	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
357804001581	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
357804001582	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
357804001583	catalytic residue [active]
357804001584	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804001585	PAS domain; Region: PAS_9; pfam13426
357804001586	putative active site [active]
357804001587	heme pocket [chemical binding]; other site
357804001588	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804001589	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804001590	metal binding site [ion binding]; metal-binding site
357804001591	active site
357804001592	I-site; other site
357804001593	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804001594	FG-GAP repeat; Region: FG-GAP_2; pfam14312
357804001595	FG-GAP repeat; Region: FG-GAP_2; pfam14312
357804001596	FG-GAP repeat; Region: FG-GAP_2; pfam14312
357804001597	FG-GAP repeat; Region: FG-GAP_2; pfam14312
357804001598	FG-GAP repeat; Region: FG-GAP_2; pfam14312
357804001599	FG-GAP repeat; Region: FG-GAP_2; pfam14312
357804001600	FG-GAP repeat; Region: FG-GAP_2; pfam14312
357804001601	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
357804001602	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
357804001603	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
357804001604	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
357804001605	putative active site [active]
357804001606	putative metal binding site [ion binding]; other site
357804001607	putative chaperone; Provisional; Region: PRK11678
357804001608	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
357804001609	nucleotide binding site [chemical binding]; other site
357804001610	putative NEF/HSP70 interaction site [polypeptide binding]; other site
357804001611	SBD interface [polypeptide binding]; other site
357804001612	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804001613	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804001614	putative active site [active]
357804001615	heme pocket [chemical binding]; other site
357804001616	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
357804001617	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804001618	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804001619	metal binding site [ion binding]; metal-binding site
357804001620	active site
357804001621	I-site; other site
357804001622	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804001623	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
357804001624	dimerization interface [polypeptide binding]; other site
357804001625	active site
357804001626	Pirin-related protein [General function prediction only]; Region: COG1741
357804001627	Pirin; Region: Pirin; pfam02678
357804001628	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
357804001629	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
357804001630	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
357804001631	putative dimer interface [polypeptide binding]; other site
357804001632	N-terminal domain interface [polypeptide binding]; other site
357804001633	putative substrate binding pocket (H-site) [chemical binding]; other site
357804001634	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
357804001635	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
357804001636	active site turn [active]
357804001637	phosphorylation site [posttranslational modification]
357804001638	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
357804001639	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
357804001640	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
357804001641	Ca binding site [ion binding]; other site
357804001642	active site
357804001643	catalytic site [active]
357804001644	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
357804001645	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
357804001646	substrate binding pocket [chemical binding]; other site
357804001647	chain length determination region; other site
357804001648	substrate-Mg2+ binding site; other site
357804001649	catalytic residues [active]
357804001650	aspartate-rich region 1; other site
357804001651	active site lid residues [active]
357804001652	aspartate-rich region 2; other site
357804001653	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
357804001654	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
357804001655	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
357804001656	GTPase CgtA; Reviewed; Region: obgE; PRK12298
357804001657	GTP1/OBG; Region: GTP1_OBG; pfam01018
357804001658	Obg GTPase; Region: Obg; cd01898
357804001659	G1 box; other site
357804001660	GTP/Mg2+ binding site [chemical binding]; other site
357804001661	Switch I region; other site
357804001662	G2 box; other site
357804001663	G3 box; other site
357804001664	Switch II region; other site
357804001665	G4 box; other site
357804001666	G5 box; other site
357804001667	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
357804001668	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
357804001669	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
357804001670	dimerization interface [polypeptide binding]; other site
357804001671	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804001672	dimer interface [polypeptide binding]; other site
357804001673	phosphorylation site [posttranslational modification]
357804001674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804001675	ATP binding site [chemical binding]; other site
357804001676	Mg2+ binding site [ion binding]; other site
357804001677	G-X-G motif; other site
357804001678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804001679	active site
357804001680	phosphorylation site [posttranslational modification]
357804001681	intermolecular recognition site; other site
357804001682	dimerization interface [polypeptide binding]; other site
357804001683	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
357804001684	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
357804001685	TRAM domain; Region: TRAM; cl01282
357804001686	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
357804001687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804001688	S-adenosylmethionine binding site [chemical binding]; other site
357804001689	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
357804001690	HD domain; Region: HD_4; pfam13328
357804001691	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
357804001692	synthetase active site [active]
357804001693	NTP binding site [chemical binding]; other site
357804001694	metal binding site [ion binding]; metal-binding site
357804001695	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
357804001696	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
357804001697	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
357804001698	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
357804001699	putative active site [active]
357804001700	catalytic triad [active]
357804001701	putative dimer interface [polypeptide binding]; other site
357804001702	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
357804001703	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
357804001704	Transporter associated domain; Region: CorC_HlyC; smart01091
357804001705	metal-binding heat shock protein; Provisional; Region: PRK00016
357804001706	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
357804001707	PhoH-like protein; Region: PhoH; pfam02562
357804001708	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
357804001709	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
357804001710	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804001711	FeS/SAM binding site; other site
357804001712	TRAM domain; Region: TRAM; pfam01938
357804001713	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
357804001714	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849
357804001715	malate dehydrogenase; Provisional; Region: PRK13529
357804001716	Malic enzyme, N-terminal domain; Region: malic; pfam00390
357804001717	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
357804001718	NAD(P) binding site [chemical binding]; other site
357804001719	DctM-like transporters; Region: DctM; pfam06808
357804001720	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
357804001721	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
357804001722	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
357804001723	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
357804001724	Conserved TM helix; Region: TM_helix; pfam05552
357804001725	Mechanosensitive ion channel; Region: MS_channel; pfam00924
357804001726	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
357804001727	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
357804001728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804001729	putative substrate translocation pore; other site
357804001730	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804001731	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804001732	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
357804001733	substrate binding pocket [chemical binding]; other site
357804001734	dimerization interface [polypeptide binding]; other site
357804001735	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
357804001736	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
357804001737	substrate binding site [chemical binding]; other site
357804001738	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
357804001739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804001740	dimer interface [polypeptide binding]; other site
357804001741	conserved gate region; other site
357804001742	putative PBP binding loops; other site
357804001743	ABC-ATPase subunit interface; other site
357804001744	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
357804001745	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
357804001746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804001747	dimer interface [polypeptide binding]; other site
357804001748	conserved gate region; other site
357804001749	putative PBP binding loops; other site
357804001750	ABC-ATPase subunit interface; other site
357804001751	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
357804001752	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804001753	Walker A/P-loop; other site
357804001754	ATP binding site [chemical binding]; other site
357804001755	Q-loop/lid; other site
357804001756	ABC transporter signature motif; other site
357804001757	Walker B; other site
357804001758	D-loop; other site
357804001759	H-loop/switch region; other site
357804001760	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
357804001761	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
357804001762	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804001763	Walker A/P-loop; other site
357804001764	ATP binding site [chemical binding]; other site
357804001765	Q-loop/lid; other site
357804001766	ABC transporter signature motif; other site
357804001767	Walker B; other site
357804001768	D-loop; other site
357804001769	H-loop/switch region; other site
357804001770	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
357804001771	Transcriptional regulators [Transcription]; Region: PurR; COG1609
357804001772	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804001773	DNA binding site [nucleotide binding]
357804001774	domain linker motif; other site
357804001775	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
357804001776	dimerization interface (closed form) [polypeptide binding]; other site
357804001777	ligand binding site [chemical binding]; other site
357804001778	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
357804001779	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
357804001780	active site
357804001781	catalytic residues [active]
357804001782	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
357804001783	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
357804001784	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
357804001785	catalytic residues [active]
357804001786	hinge region; other site
357804001787	alpha helical domain; other site
357804001788	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
357804001789	active site
357804001790	catalytic residues [active]
357804001791	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
357804001792	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
357804001793	Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148
357804001794	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
357804001795	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804001796	Walker A/P-loop; other site
357804001797	ATP binding site [chemical binding]; other site
357804001798	Q-loop/lid; other site
357804001799	ABC transporter signature motif; other site
357804001800	Walker B; other site
357804001801	D-loop; other site
357804001802	H-loop/switch region; other site
357804001803	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
357804001804	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804001805	Walker A/P-loop; other site
357804001806	ATP binding site [chemical binding]; other site
357804001807	Q-loop/lid; other site
357804001808	ABC transporter signature motif; other site
357804001809	Walker B; other site
357804001810	D-loop; other site
357804001811	H-loop/switch region; other site
357804001812	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
357804001813	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
357804001814	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
357804001815	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
357804001816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804001817	dimer interface [polypeptide binding]; other site
357804001818	conserved gate region; other site
357804001819	putative PBP binding loops; other site
357804001820	ABC-ATPase subunit interface; other site
357804001821	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
357804001822	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
357804001823	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804001824	dimer interface [polypeptide binding]; other site
357804001825	conserved gate region; other site
357804001826	putative PBP binding loops; other site
357804001827	ABC-ATPase subunit interface; other site
357804001828	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
357804001829	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
357804001830	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
357804001831	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
357804001832	ligand binding site [chemical binding]; other site
357804001833	homodimer interface [polypeptide binding]; other site
357804001834	NAD(P) binding site [chemical binding]; other site
357804001835	trimer interface B [polypeptide binding]; other site
357804001836	trimer interface A [polypeptide binding]; other site
357804001837	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
357804001838	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
357804001839	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
357804001840	active site
357804001841	ATP-dependent helicase HepA; Validated; Region: PRK04914
357804001842	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804001843	ATP binding site [chemical binding]; other site
357804001844	putative Mg++ binding site [ion binding]; other site
357804001845	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804001846	nucleotide binding region [chemical binding]; other site
357804001847	ATP-binding site [chemical binding]; other site
357804001848	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
357804001849	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804001850	DNA-binding site [nucleotide binding]; DNA binding site
357804001851	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
357804001852	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804001853	homodimer interface [polypeptide binding]; other site
357804001854	catalytic residue [active]
357804001855	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
357804001856	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
357804001857	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
357804001858	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
357804001859	DctM-like transporters; Region: DctM; pfam06808
357804001860	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
357804001861	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
357804001862	Walker A/P-loop; other site
357804001863	ATP binding site [chemical binding]; other site
357804001864	Q-loop/lid; other site
357804001865	ABC transporter signature motif; other site
357804001866	Walker B; other site
357804001867	D-loop; other site
357804001868	H-loop/switch region; other site
357804001869	inner membrane transport permease; Provisional; Region: PRK15066
357804001870	Putative methyltransferase; Region: Methyltransf_4; cl17290
357804001871	TMAO/DMSO reductase; Reviewed; Region: PRK05363
357804001872	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
357804001873	Moco binding site; other site
357804001874	metal coordination site [ion binding]; other site
357804001875	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
357804001876	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
357804001877	tetramerization interface [polypeptide binding]; other site
357804001878	active site
357804001879	pantoate--beta-alanine ligase; Region: panC; TIGR00018
357804001880	Pantoate-beta-alanine ligase; Region: PanC; cd00560
357804001881	active site
357804001882	ATP-binding site [chemical binding]; other site
357804001883	pantoate-binding site; other site
357804001884	HXXH motif; other site
357804001885	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
357804001886	oligomerization interface [polypeptide binding]; other site
357804001887	active site
357804001888	metal binding site [ion binding]; metal-binding site
357804001889	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
357804001890	catalytic center binding site [active]
357804001891	ATP binding site [chemical binding]; other site
357804001892	poly(A) polymerase; Region: pcnB; TIGR01942
357804001893	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
357804001894	active site
357804001895	NTP binding site [chemical binding]; other site
357804001896	metal binding triad [ion binding]; metal-binding site
357804001897	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
357804001898	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
357804001899	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
357804001900	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
357804001901	active site
357804001902	nucleotide binding site [chemical binding]; other site
357804001903	HIGH motif; other site
357804001904	KMSKS motif; other site
357804001905	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
357804001906	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
357804001907	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804001908	ATP binding site [chemical binding]; other site
357804001909	putative Mg++ binding site [ion binding]; other site
357804001910	nucleotide binding region [chemical binding]; other site
357804001911	helicase superfamily c-terminal domain; Region: HELICc; smart00490
357804001912	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
357804001913	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
357804001914	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
357804001915	Short C-terminal domain; Region: SHOCT; pfam09851
357804001916	hypothetical protein; Provisional; Region: PRK02237
357804001917	PilX N-terminal; Region: PilX_N; pfam14341
357804001918	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
357804001919	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804001920	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
357804001921	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
357804001922	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
357804001923	active site
357804001924	ADP/pyrophosphate binding site [chemical binding]; other site
357804001925	dimerization interface [polypeptide binding]; other site
357804001926	allosteric effector site; other site
357804001927	fructose-1,6-bisphosphate binding site; other site
357804001928	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
357804001929	LysE type translocator; Region: LysE; cl00565
357804001930	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
357804001931	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
357804001932	Transglycosylase; Region: Transgly; pfam00912
357804001933	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
357804001934	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
357804001935	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
357804001936	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
357804001937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804001938	S-adenosylmethionine binding site [chemical binding]; other site
357804001939	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
357804001940	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
357804001941	ligand binding site [chemical binding]; other site
357804001942	NAD binding site [chemical binding]; other site
357804001943	tetramer interface [polypeptide binding]; other site
357804001944	catalytic site [active]
357804001945	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
357804001946	L-serine binding site [chemical binding]; other site
357804001947	ACT domain interface; other site
357804001948	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
357804001949	tetramer (dimer of dimers) interface [polypeptide binding]; other site
357804001950	active site
357804001951	dimer interface [polypeptide binding]; other site
357804001952	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
357804001953	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
357804001954	Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935
357804001955	Cell division protein ZapA; Region: ZapA; pfam05164
357804001956	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
357804001957	proline aminopeptidase P II; Provisional; Region: PRK10879
357804001958	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
357804001959	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
357804001960	active site
357804001961	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
357804001962	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
357804001963	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
357804001964	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
357804001965	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
357804001966	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
357804001967	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
357804001968	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
357804001969	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
357804001970	Transcriptional regulators [Transcription]; Region: MarR; COG1846
357804001971	MarR family; Region: MarR_2; pfam12802
357804001972	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
357804001973	MarR family; Region: MarR; pfam01047
357804001974	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
357804001975	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
357804001976	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
357804001977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804001978	dimer interface [polypeptide binding]; other site
357804001979	conserved gate region; other site
357804001980	putative PBP binding loops; other site
357804001981	ABC-ATPase subunit interface; other site
357804001982	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
357804001983	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
357804001984	Walker A/P-loop; other site
357804001985	ATP binding site [chemical binding]; other site
357804001986	Q-loop/lid; other site
357804001987	ABC transporter signature motif; other site
357804001988	Walker B; other site
357804001989	D-loop; other site
357804001990	H-loop/switch region; other site
357804001991	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
357804001992	KpsF/GutQ family protein; Region: kpsF; TIGR00393
357804001993	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
357804001994	putative active site [active]
357804001995	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
357804001996	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
357804001997	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
357804001998	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
357804001999	Protein of unknown function (DUF1145); Region: DUF1145; cl11481
357804002000	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
357804002001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804002002	S-adenosylmethionine binding site [chemical binding]; other site
357804002003	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
357804002004	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
357804002005	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
357804002006	P loop; other site
357804002007	GTP binding site [chemical binding]; other site
357804002008	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
357804002009	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804002010	Walker A/P-loop; other site
357804002011	ATP binding site [chemical binding]; other site
357804002012	Q-loop/lid; other site
357804002013	ABC transporter signature motif; other site
357804002014	Walker B; other site
357804002015	D-loop; other site
357804002016	H-loop/switch region; other site
357804002017	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
357804002018	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
357804002019	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
357804002020	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
357804002021	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
357804002022	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
357804002023	DNA binding residues [nucleotide binding]
357804002024	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
357804002025	Prephenate dehydratase; Region: PDT; pfam00800
357804002026	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
357804002027	putative L-Phe binding site [chemical binding]; other site
357804002028	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
357804002029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804002030	S-adenosylmethionine binding site [chemical binding]; other site
357804002031	glutamate racemase; Provisional; Region: PRK00865
357804002032	NnrS protein; Region: NnrS; pfam05940
357804002033	Predicted transcriptional regulator [Transcription]; Region: COG1959
357804002034	Transcriptional regulator; Region: Rrf2; cl17282
357804002035	HPP family; Region: HPP; pfam04982
357804002036	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
357804002037	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
357804002038	Domain of unknown function (DUF4202); Region: DUF4202; pfam13875
357804002039	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
357804002040	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
357804002041	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
357804002042	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
357804002043	ligand binding site [chemical binding]; other site
357804002044	flexible hinge region; other site
357804002045	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
357804002046	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
357804002047	GTP-binding protein LepA; Provisional; Region: PRK05433
357804002048	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
357804002049	G1 box; other site
357804002050	putative GEF interaction site [polypeptide binding]; other site
357804002051	GTP/Mg2+ binding site [chemical binding]; other site
357804002052	Switch I region; other site
357804002053	G2 box; other site
357804002054	G3 box; other site
357804002055	Switch II region; other site
357804002056	G4 box; other site
357804002057	G5 box; other site
357804002058	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
357804002059	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
357804002060	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
357804002061	signal peptidase I; Provisional; Region: PRK10861
357804002062	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
357804002063	Catalytic site [active]
357804002064	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
357804002065	ribonuclease III; Reviewed; Region: rnc; PRK00102
357804002066	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
357804002067	dimerization interface [polypeptide binding]; other site
357804002068	active site
357804002069	metal binding site [ion binding]; metal-binding site
357804002070	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
357804002071	dsRNA binding site [nucleotide binding]; other site
357804002072	GTPase Era; Reviewed; Region: era; PRK00089
357804002073	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
357804002074	G1 box; other site
357804002075	GTP/Mg2+ binding site [chemical binding]; other site
357804002076	Switch I region; other site
357804002077	G2 box; other site
357804002078	Switch II region; other site
357804002079	G3 box; other site
357804002080	G4 box; other site
357804002081	G5 box; other site
357804002082	KH domain; Region: KH_2; pfam07650
357804002083	Recombination protein O N terminal; Region: RecO_N; pfam11967
357804002084	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
357804002085	Recombination protein O C terminal; Region: RecO_C; pfam02565
357804002086	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
357804002087	active site
357804002088	hydrophilic channel; other site
357804002089	dimerization interface [polypeptide binding]; other site
357804002090	catalytic residues [active]
357804002091	active site lid [active]
357804002092	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
357804002093	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
357804002094	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
357804002095	catalytic residue [active]
357804002096	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
357804002097	DctM-like transporters; Region: DctM; pfam06808
357804002098	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
357804002099	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
357804002100	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
357804002101	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
357804002102	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
357804002103	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
357804002104	substrate binding site [chemical binding]; other site
357804002105	dimer interface [polypeptide binding]; other site
357804002106	NADP binding site [chemical binding]; other site
357804002107	catalytic residues [active]
357804002108	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
357804002109	substrate binding site [chemical binding]; other site
357804002110	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
357804002111	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
357804002112	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
357804002113	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
357804002114	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
357804002115	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
357804002116	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
357804002117	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
357804002118	FAD binding pocket [chemical binding]; other site
357804002119	FAD binding motif [chemical binding]; other site
357804002120	phosphate binding motif [ion binding]; other site
357804002121	beta-alpha-beta structure motif; other site
357804002122	NAD(p) ribose binding residues [chemical binding]; other site
357804002123	NAD binding pocket [chemical binding]; other site
357804002124	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
357804002125	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
357804002126	catalytic loop [active]
357804002127	iron binding site [ion binding]; other site
357804002128	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
357804002129	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
357804002130	substrate binding site [chemical binding]; other site
357804002131	oxyanion hole (OAH) forming residues; other site
357804002132	trimer interface [polypeptide binding]; other site
357804002133	enoyl-CoA hydratase; Provisional; Region: PRK08140
357804002134	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
357804002135	substrate binding site [chemical binding]; other site
357804002136	oxyanion hole (OAH) forming residues; other site
357804002137	trimer interface [polypeptide binding]; other site
357804002138	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
357804002139	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
357804002140	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
357804002141	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
357804002142	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
357804002143	CoenzymeA binding site [chemical binding]; other site
357804002144	subunit interaction site [polypeptide binding]; other site
357804002145	PHB binding site; other site
357804002146	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
357804002147	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
357804002148	dimer interface [polypeptide binding]; other site
357804002149	active site
357804002150	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
357804002151	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
357804002152	active site
357804002153	AMP binding site [chemical binding]; other site
357804002154	homodimer interface [polypeptide binding]; other site
357804002155	acyl-activating enzyme (AAE) consensus motif; other site
357804002156	CoA binding site [chemical binding]; other site
357804002157	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
357804002158	PaaX-like protein; Region: PaaX; pfam07848
357804002159	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
357804002160	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
357804002161	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
357804002162	putative trimer interface [polypeptide binding]; other site
357804002163	putative metal binding site [ion binding]; other site
357804002164	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
357804002165	Protein export membrane protein; Region: SecD_SecF; cl14618
357804002166	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
357804002167	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
357804002168	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804002169	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
357804002170	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
357804002171	homodimer interface [polypeptide binding]; other site
357804002172	metal binding site [ion binding]; metal-binding site
357804002173	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
357804002174	homodimer interface [polypeptide binding]; other site
357804002175	active site
357804002176	putative chemical substrate binding site [chemical binding]; other site
357804002177	metal binding site [ion binding]; metal-binding site
357804002178	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
357804002179	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
357804002180	eyelet of channel; other site
357804002181	trimer interface [polypeptide binding]; other site
357804002182	CTP synthetase; Validated; Region: pyrG; PRK05380
357804002183	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
357804002184	Catalytic site [active]
357804002185	active site
357804002186	UTP binding site [chemical binding]; other site
357804002187	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
357804002188	active site
357804002189	putative oxyanion hole; other site
357804002190	catalytic triad [active]
357804002191	enolase; Provisional; Region: eno; PRK00077
357804002192	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
357804002193	dimer interface [polypeptide binding]; other site
357804002194	metal binding site [ion binding]; metal-binding site
357804002195	substrate binding pocket [chemical binding]; other site
357804002196	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
357804002197	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
357804002198	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
357804002199	substrate binding site; other site
357804002200	dimer interface; other site
357804002201	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
357804002202	homotrimer interaction site [polypeptide binding]; other site
357804002203	zinc binding site [ion binding]; other site
357804002204	CDP-binding sites; other site
357804002205	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
357804002206	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
357804002207	Permutation of conserved domain; other site
357804002208	active site
357804002209	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
357804002210	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
357804002211	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
357804002212	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
357804002213	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804002214	Peptidase family M23; Region: Peptidase_M23; pfam01551
357804002215	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
357804002216	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
357804002217	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
357804002218	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
357804002219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
357804002220	DNA binding residues [nucleotide binding]
357804002221	Protein of unknown function (DUF3545); Region: DUF3545; pfam12065
357804002222	hypothetical protein; Provisional; Region: PRK10506
357804002223	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
357804002224	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
357804002225	YcxB-like protein; Region: YcxB; pfam14317
357804002226	cystathionine beta-lyase; Provisional; Region: PRK09028
357804002227	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
357804002228	homodimer interface [polypeptide binding]; other site
357804002229	substrate-cofactor binding pocket; other site
357804002230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804002231	catalytic residue [active]
357804002232	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
357804002233	thymidine kinase; Provisional; Region: PRK04296
357804002234	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
357804002235	Peptidase family M50; Region: Peptidase_M50; pfam02163
357804002236	active site
357804002237	putative substrate binding region [chemical binding]; other site
357804002238	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
357804002239	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
357804002240	Imelysin; Region: Peptidase_M75; cl09159
357804002241	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
357804002242	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
357804002243	outer membrane protein A; Reviewed; Region: PRK10808
357804002244	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
357804002245	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
357804002246	ligand binding site [chemical binding]; other site
357804002247	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
357804002248	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
357804002249	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
357804002250	Walker A/P-loop; other site
357804002251	ATP binding site [chemical binding]; other site
357804002252	Q-loop/lid; other site
357804002253	ABC transporter signature motif; other site
357804002254	Walker B; other site
357804002255	D-loop; other site
357804002256	H-loop/switch region; other site
357804002257	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
357804002258	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
357804002259	active site
357804002260	purine riboside binding site [chemical binding]; other site
357804002261	Domain of unknown function (DUF368); Region: DUF368; pfam04018
357804002262	Citrate transporter; Region: CitMHS; pfam03600
357804002263	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
357804002264	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
357804002265	putative active site [active]
357804002266	putative CoA binding site [chemical binding]; other site
357804002267	nudix motif; other site
357804002268	metal binding site [ion binding]; metal-binding site
357804002269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804002270	S-adenosylmethionine binding site [chemical binding]; other site
357804002271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804002272	S-adenosylmethionine binding site [chemical binding]; other site
357804002273	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
357804002274	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
357804002275	dimer interface [polypeptide binding]; other site
357804002276	anticodon binding site; other site
357804002277	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
357804002278	homodimer interface [polypeptide binding]; other site
357804002279	motif 1; other site
357804002280	active site
357804002281	motif 2; other site
357804002282	GAD domain; Region: GAD; pfam02938
357804002283	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
357804002284	active site
357804002285	motif 3; other site
357804002286	OmpW family; Region: OmpW; cl17427
357804002287	Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968
357804002288	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
357804002289	dinuclear metal binding motif [ion binding]; other site
357804002290	cyanate hydratase; Validated; Region: PRK02866
357804002291	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
357804002292	oligomer interface [polypeptide binding]; other site
357804002293	active site
357804002294	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
357804002295	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
357804002296	active site
357804002297	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
357804002298	Catalytic domain of Protein Kinases; Region: PKc; cd00180
357804002299	active site
357804002300	ATP binding site [chemical binding]; other site
357804002301	substrate binding site [chemical binding]; other site
357804002302	activation loop (A-loop); other site
357804002303	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
357804002304	DNA methylase; Region: N6_N4_Mtase; pfam01555
357804002305	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
357804002306	aromatic arch; other site
357804002307	DCoH dimer interaction site [polypeptide binding]; other site
357804002308	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
357804002309	DCoH tetramer interaction site [polypeptide binding]; other site
357804002310	substrate binding site [chemical binding]; other site
357804002311	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
357804002312	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
357804002313	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
357804002314	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
357804002315	DctM-like transporters; Region: DctM; pfam06808
357804002316	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
357804002317	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
357804002318	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
357804002319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804002320	active site
357804002321	phosphorylation site [posttranslational modification]
357804002322	intermolecular recognition site; other site
357804002323	dimerization interface [polypeptide binding]; other site
357804002324	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804002325	Walker A motif; other site
357804002326	ATP binding site [chemical binding]; other site
357804002327	Walker B motif; other site
357804002328	arginine finger; other site
357804002329	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
357804002330	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
357804002331	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
357804002332	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804002333	dimer interface [polypeptide binding]; other site
357804002334	phosphorylation site [posttranslational modification]
357804002335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804002336	ATP binding site [chemical binding]; other site
357804002337	Mg2+ binding site [ion binding]; other site
357804002338	G-X-G motif; other site
357804002339	hypothetical protein; Provisional; Region: PRK13677
357804002340	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
357804002341	active site
357804002342	putative DNA-binding cleft [nucleotide binding]; other site
357804002343	dimer interface [polypeptide binding]; other site
357804002344	Predicted permeases [General function prediction only]; Region: RarD; COG2962
357804002345	EamA-like transporter family; Region: EamA; cl17759
357804002346	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
357804002347	RuvA N terminal domain; Region: RuvA_N; pfam01330
357804002348	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
357804002349	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
357804002350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804002351	Walker A motif; other site
357804002352	ATP binding site [chemical binding]; other site
357804002353	Walker B motif; other site
357804002354	arginine finger; other site
357804002355	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
357804002356	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
357804002357	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
357804002358	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
357804002359	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
357804002360	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
357804002361	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
357804002362	active site
357804002363	TolQ protein; Region: tolQ; TIGR02796
357804002364	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
357804002365	TolR protein; Region: tolR; TIGR02801
357804002366	TolA protein; Region: tolA_full; TIGR02794
357804002367	TolA C-terminal; Region: TolA; pfam06519
357804002368	TolA protein; Region: tolA_full; TIGR02794
357804002369	translocation protein TolB; Provisional; Region: tolB; PRK04792
357804002370	TolB amino-terminal domain; Region: TolB_N; pfam04052
357804002371	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
357804002372	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
357804002373	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
357804002374	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
357804002375	ligand binding site [chemical binding]; other site
357804002376	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
357804002377	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804002378	TPR motif; other site
357804002379	binding surface
357804002380	quinolinate synthetase; Provisional; Region: PRK09375
357804002381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
357804002382	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
357804002383	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
357804002384	endonuclease III; Provisional; Region: PRK10702
357804002385	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
357804002386	minor groove reading motif; other site
357804002387	helix-hairpin-helix signature motif; other site
357804002388	substrate binding pocket [chemical binding]; other site
357804002389	active site
357804002390	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
357804002391	electron transport complex RsxE subunit; Provisional; Region: PRK12405
357804002392	FMN-binding domain; Region: FMN_bind; cl01081
357804002393	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
357804002394	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
357804002395	SLBB domain; Region: SLBB; pfam10531
357804002396	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
357804002397	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
357804002398	electron transport complex protein RnfB; Provisional; Region: PRK05113
357804002399	Putative Fe-S cluster; Region: FeS; pfam04060
357804002400	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
357804002401	electron transport complex protein RsxA; Provisional; Region: PRK05151
357804002402	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
357804002403	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
357804002404	ATP cone domain; Region: ATP-cone; pfam03477
357804002405	Class III ribonucleotide reductase; Region: RNR_III; cd01675
357804002406	effector binding site; other site
357804002407	active site
357804002408	Zn binding site [ion binding]; other site
357804002409	glycine loop; other site
357804002410	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121
357804002411	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
357804002412	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
357804002413	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
357804002414	Clp amino terminal domain; Region: Clp_N; pfam02861
357804002415	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804002416	Walker A motif; other site
357804002417	ATP binding site [chemical binding]; other site
357804002418	Walker B motif; other site
357804002419	arginine finger; other site
357804002420	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804002421	Walker A motif; other site
357804002422	ATP binding site [chemical binding]; other site
357804002423	Walker B motif; other site
357804002424	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
357804002425	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
357804002426	rRNA binding site [nucleotide binding]; other site
357804002427	predicted 30S ribosome binding site; other site
357804002428	BolA-like protein; Region: BolA; cl00386
357804002429	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
357804002430	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
357804002431	E3 interaction surface; other site
357804002432	lipoyl attachment site [posttranslational modification]; other site
357804002433	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
357804002434	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
357804002435	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
357804002436	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
357804002437	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
357804002438	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
357804002439	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
357804002440	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
357804002441	catalytic loop [active]
357804002442	iron binding site [ion binding]; other site
357804002443	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
357804002444	FAD binding pocket [chemical binding]; other site
357804002445	FAD binding motif [chemical binding]; other site
357804002446	phosphate binding motif [ion binding]; other site
357804002447	beta-alpha-beta structure motif; other site
357804002448	NAD binding pocket [chemical binding]; other site
357804002449	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
357804002450	ApbE family; Region: ApbE; pfam02424
357804002451	Protein of unknown function (DUF539); Region: DUF539; pfam04400
357804002452	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
357804002453	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804002454	DNA-binding site [nucleotide binding]; DNA binding site
357804002455	RNA-binding motif; other site
357804002456	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
357804002457	trimer interface [polypeptide binding]; other site
357804002458	active site
357804002459	hypothetical protein; Provisional; Region: PRK05939
357804002460	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
357804002461	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
357804002462	catalytic residue [active]
357804002463	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
357804002464	active site
357804002465	NTP binding site [chemical binding]; other site
357804002466	metal binding triad [ion binding]; metal-binding site
357804002467	antibiotic binding site [chemical binding]; other site
357804002468	Protein of unknown function DUF86; Region: DUF86; pfam01934
357804002469	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
357804002470	active site
357804002471	NTP binding site [chemical binding]; other site
357804002472	metal binding triad [ion binding]; metal-binding site
357804002473	antibiotic binding site [chemical binding]; other site
357804002474	Protein of unknown function DUF86; Region: DUF86; pfam01934
357804002475	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
357804002476	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
357804002477	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
357804002478	SLBB domain; Region: SLBB; pfam10531
357804002479	SLBB domain; Region: SLBB; pfam10531
357804002480	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
357804002481	SLBB domain; Region: SLBB; pfam10531
357804002482	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
357804002483	Chain length determinant protein; Region: Wzz; pfam02706
357804002484	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
357804002485	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
357804002486	active site
357804002487	GDP-Mannose binding site [chemical binding]; other site
357804002488	dimer interface [polypeptide binding]; other site
357804002489	modified nudix motif
357804002490	metal binding site [ion binding]; metal-binding site
357804002491	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
357804002492	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
357804002493	Substrate binding site; other site
357804002494	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
357804002495	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
357804002496	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
357804002497	Transposase [DNA replication, recombination, and repair]; Region: COG5433
357804002498	Transposase [DNA replication, recombination, and repair]; Region: COG5433
357804002499	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
357804002500	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
357804002501	active site
357804002502	substrate binding site [chemical binding]; other site
357804002503	metal binding site [ion binding]; metal-binding site
357804002504	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
357804002505	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
357804002506	NADP-binding site; other site
357804002507	homotetramer interface [polypeptide binding]; other site
357804002508	substrate binding site [chemical binding]; other site
357804002509	homodimer interface [polypeptide binding]; other site
357804002510	active site
357804002511	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
357804002512	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
357804002513	NADP binding site [chemical binding]; other site
357804002514	active site
357804002515	putative substrate binding site [chemical binding]; other site
357804002516	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
357804002517	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
357804002518	catalytic loop [active]
357804002519	iron binding site [ion binding]; other site
357804002520	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
357804002521	FAD binding pocket [chemical binding]; other site
357804002522	FAD binding motif [chemical binding]; other site
357804002523	phosphate binding motif [ion binding]; other site
357804002524	beta-alpha-beta structure motif; other site
357804002525	NAD binding pocket [chemical binding]; other site
357804002526	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
357804002527	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
357804002528	substrate binding site; other site
357804002529	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
357804002530	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
357804002531	NAD binding site [chemical binding]; other site
357804002532	homotetramer interface [polypeptide binding]; other site
357804002533	homodimer interface [polypeptide binding]; other site
357804002534	substrate binding site [chemical binding]; other site
357804002535	active site
357804002536	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
357804002537	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
357804002538	inhibitor-cofactor binding pocket; inhibition site
357804002539	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804002540	catalytic residue [active]
357804002541	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804002542	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
357804002543	NAD(P) binding site [chemical binding]; other site
357804002544	active site
357804002545	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
357804002546	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
357804002547	NAD binding site [chemical binding]; other site
357804002548	homotetramer interface [polypeptide binding]; other site
357804002549	homodimer interface [polypeptide binding]; other site
357804002550	active site
357804002551	substrate binding site [chemical binding]; other site
357804002552	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
357804002553	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
357804002554	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
357804002555	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
357804002556	active site
357804002557	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
357804002558	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
357804002559	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
357804002560	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
357804002561	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
357804002562	Transposase [DNA replication, recombination, and repair]; Region: COG5433
357804002563	Transposase [DNA replication, recombination, and repair]; Region: COG5433
357804002564	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
357804002565	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
357804002566	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
357804002567	NAD(P) binding site [chemical binding]; other site
357804002568	homodimer interface [polypeptide binding]; other site
357804002569	substrate binding site [chemical binding]; other site
357804002570	active site
357804002571	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
357804002572	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
357804002573	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
357804002574	NADP binding site [chemical binding]; other site
357804002575	active site
357804002576	putative substrate binding site [chemical binding]; other site
357804002577	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
357804002578	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
357804002579	active site
357804002580	homodimer interface [polypeptide binding]; other site
357804002581	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
357804002582	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
357804002583	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
357804002584	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
357804002585	Transposase [DNA replication, recombination, and repair]; Region: COG5433
357804002586	Transposase [DNA replication, recombination, and repair]; Region: COG5433
357804002587	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
357804002588	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
357804002589	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
357804002590	Mg++ binding site [ion binding]; other site
357804002591	putative catalytic motif [active]
357804002592	substrate binding site [chemical binding]; other site
357804002593	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
357804002594	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
357804002595	Active Sites [active]
357804002596	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
357804002597	four helix bundle protein; Region: TIGR02436
357804002598	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
357804002599	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
357804002600	CysD dimerization site [polypeptide binding]; other site
357804002601	G1 box; other site
357804002602	putative GEF interaction site [polypeptide binding]; other site
357804002603	GTP/Mg2+ binding site [chemical binding]; other site
357804002604	Switch I region; other site
357804002605	G2 box; other site
357804002606	G3 box; other site
357804002607	Switch II region; other site
357804002608	G4 box; other site
357804002609	G5 box; other site
357804002610	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
357804002611	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
357804002612	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
357804002613	TrkA-C domain; Region: TrkA_C; pfam02080
357804002614	TrkA-C domain; Region: TrkA_C; pfam02080
357804002615	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
357804002616	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
357804002617	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
357804002618	ligand-binding site [chemical binding]; other site
357804002619	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
357804002620	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
357804002621	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
357804002622	Transposase [DNA replication, recombination, and repair]; Region: COG5433
357804002623	Transposase [DNA replication, recombination, and repair]; Region: COG5433
357804002624	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
357804002625	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
357804002626	G1 box; other site
357804002627	putative GEF interaction site [polypeptide binding]; other site
357804002628	GTP/Mg2+ binding site [chemical binding]; other site
357804002629	Switch I region; other site
357804002630	G2 box; other site
357804002631	G3 box; other site
357804002632	Switch II region; other site
357804002633	G4 box; other site
357804002634	G5 box; other site
357804002635	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
357804002636	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
357804002637	active site
357804002638	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
357804002639	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
357804002640	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
357804002641	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
357804002642	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
357804002643	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804002644	S-adenosylmethionine binding site [chemical binding]; other site
357804002645	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
357804002646	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804002647	Walker A motif; other site
357804002648	ATP binding site [chemical binding]; other site
357804002649	Walker B motif; other site
357804002650	arginine finger; other site
357804002651	Peptidase family M41; Region: Peptidase_M41; pfam01434
357804002652	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
357804002653	dihydropteroate synthase; Region: DHPS; TIGR01496
357804002654	substrate binding pocket [chemical binding]; other site
357804002655	dimer interface [polypeptide binding]; other site
357804002656	inhibitor binding site; inhibition site
357804002657	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
357804002658	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
357804002659	active site
357804002660	substrate binding site [chemical binding]; other site
357804002661	metal binding site [ion binding]; metal-binding site
357804002662	Preprotein translocase SecG subunit; Region: SecG; pfam03840
357804002663	ribosome maturation protein RimP; Reviewed; Region: PRK00092
357804002664	Sm and related proteins; Region: Sm_like; cl00259
357804002665	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
357804002666	putative oligomer interface [polypeptide binding]; other site
357804002667	putative RNA binding site [nucleotide binding]; other site
357804002668	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
357804002669	NusA N-terminal domain; Region: NusA_N; pfam08529
357804002670	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
357804002671	RNA binding site [nucleotide binding]; other site
357804002672	homodimer interface [polypeptide binding]; other site
357804002673	NusA-like KH domain; Region: KH_5; pfam13184
357804002674	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
357804002675	G-X-X-G motif; other site
357804002676	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
357804002677	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
357804002678	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
357804002679	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
357804002680	translation initiation factor IF-2; Region: IF-2; TIGR00487
357804002681	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
357804002682	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
357804002683	G1 box; other site
357804002684	putative GEF interaction site [polypeptide binding]; other site
357804002685	GTP/Mg2+ binding site [chemical binding]; other site
357804002686	Switch I region; other site
357804002687	G2 box; other site
357804002688	G3 box; other site
357804002689	Switch II region; other site
357804002690	G4 box; other site
357804002691	G5 box; other site
357804002692	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
357804002693	Translation-initiation factor 2; Region: IF-2; pfam11987
357804002694	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
357804002695	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
357804002696	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
357804002697	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
357804002698	RNA binding site [nucleotide binding]; other site
357804002699	active site
357804002700	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
357804002701	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
357804002702	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
357804002703	zinc binding site [ion binding]; other site
357804002704	putative ligand binding site [chemical binding]; other site
357804002705	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
357804002706	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
357804002707	TM-ABC transporter signature motif; other site
357804002708	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
357804002709	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804002710	Walker A/P-loop; other site
357804002711	ATP binding site [chemical binding]; other site
357804002712	Q-loop/lid; other site
357804002713	ABC transporter signature motif; other site
357804002714	Walker B; other site
357804002715	D-loop; other site
357804002716	H-loop/switch region; other site
357804002717	Ping_R0041; ribosomal S15 leader as predicted by Rfam (RF00114), score 27.47
357804002718	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
357804002719	16S/18S rRNA binding site [nucleotide binding]; other site
357804002720	S13e-L30e interaction site [polypeptide binding]; other site
357804002721	25S rRNA binding site [nucleotide binding]; other site
357804002722	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
357804002723	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
357804002724	RNase E interface [polypeptide binding]; other site
357804002725	trimer interface [polypeptide binding]; other site
357804002726	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
357804002727	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
357804002728	RNase E interface [polypeptide binding]; other site
357804002729	trimer interface [polypeptide binding]; other site
357804002730	active site
357804002731	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
357804002732	putative nucleic acid binding region [nucleotide binding]; other site
357804002733	G-X-X-G motif; other site
357804002734	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
357804002735	RNA binding site [nucleotide binding]; other site
357804002736	domain interface; other site
357804002737	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
357804002738	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
357804002739	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
357804002740	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
357804002741	aromatic acid decarboxylase; Validated; Region: PRK05920
357804002742	Flavoprotein; Region: Flavoprotein; pfam02441
357804002743	5S ribosomal RNA region; shows weak similarity to 5S central region
357804002744	Protein of unknown function (DUF2982); Region: DUF2982; pfam11201
357804002745	CreA protein; Region: CreA; pfam05981
357804002746	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071
357804002747	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
357804002748	Protein of unknown function (DUF3549); Region: DUF3549; pfam12069
357804002749	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
357804002750	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
357804002751	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
357804002752	dimerization interface [polypeptide binding]; other site
357804002753	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804002754	putative active site [active]
357804002755	heme pocket [chemical binding]; other site
357804002756	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804002757	dimer interface [polypeptide binding]; other site
357804002758	phosphorylation site [posttranslational modification]
357804002759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804002760	ATP binding site [chemical binding]; other site
357804002761	Mg2+ binding site [ion binding]; other site
357804002762	G-X-G motif; other site
357804002763	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
357804002764	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
357804002765	ATP binding site [chemical binding]; other site
357804002766	Mg++ binding site [ion binding]; other site
357804002767	motif III; other site
357804002768	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804002769	nucleotide binding region [chemical binding]; other site
357804002770	ATP-binding site [chemical binding]; other site
357804002771	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
357804002772	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
357804002773	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
357804002774	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
357804002775	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
357804002776	oligomerisation interface [polypeptide binding]; other site
357804002777	mobile loop; other site
357804002778	roof hairpin; other site
357804002779	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
357804002780	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
357804002781	ring oligomerisation interface [polypeptide binding]; other site
357804002782	ATP/Mg binding site [chemical binding]; other site
357804002783	stacking interactions; other site
357804002784	hinge regions; other site
357804002785	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
357804002786	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
357804002787	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
357804002788	hypothetical protein; Provisional; Region: PRK07236
357804002789	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
357804002790	Uncharacterized conserved protein [Function unknown]; Region: COG2128
357804002791	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
357804002792	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
357804002793	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
357804002794	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
357804002795	putative ATP binding site [chemical binding]; other site
357804002796	putative substrate interface [chemical binding]; other site
357804002797	ketol-acid reductoisomerase; Validated; Region: PRK05225
357804002798	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
357804002799	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
357804002800	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
357804002801	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
357804002802	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
357804002803	active site residue [active]
357804002804	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
357804002805	active site residue [active]
357804002806	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804002807	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
357804002808	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
357804002809	putative dimerization interface [polypeptide binding]; other site
357804002810	Flagellin N-methylase; Region: FliB; pfam03692
357804002811	Transcriptional activator HlyU; Region: HlyU; pfam10115
357804002812	Membrane fusogenic activity; Region: BMFP; pfam04380
357804002813	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
357804002814	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
357804002815	agmatinase; Region: agmatinase; TIGR01230
357804002816	oligomer interface [polypeptide binding]; other site
357804002817	putative active site [active]
357804002818	Mn binding site [ion binding]; other site
357804002819	arginine decarboxylase; Provisional; Region: PRK05354
357804002820	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
357804002821	dimer interface [polypeptide binding]; other site
357804002822	active site
357804002823	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
357804002824	catalytic residues [active]
357804002825	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
357804002826	RNase E inhibitor protein; Provisional; Region: PRK11191
357804002827	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
357804002828	putative acyl-acceptor binding pocket; other site
357804002829	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
357804002830	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
357804002831	CAP-like domain; other site
357804002832	active site
357804002833	primary dimer interface [polypeptide binding]; other site
357804002834	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
357804002835	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
357804002836	inhibitor-cofactor binding pocket; inhibition site
357804002837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804002838	catalytic residue [active]
357804002839	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
357804002840	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
357804002841	Cl- selectivity filter; other site
357804002842	Cl- binding residues [ion binding]; other site
357804002843	pore gating glutamate residue; other site
357804002844	dimer interface [polypeptide binding]; other site
357804002845	H+/Cl- coupling transport residue; other site
357804002846	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
357804002847	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
357804002848	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804002849	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
357804002850	Predicted membrane protein [Function unknown]; Region: COG2860
357804002851	UPF0126 domain; Region: UPF0126; pfam03458
357804002852	UPF0126 domain; Region: UPF0126; pfam03458
357804002853	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
357804002854	active site residue [active]
357804002855	N-acetylglutamate synthase; Validated; Region: PRK05279
357804002856	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
357804002857	putative feedback inhibition sensing region; other site
357804002858	putative nucleotide binding site [chemical binding]; other site
357804002859	putative substrate binding site [chemical binding]; other site
357804002860	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804002861	Coenzyme A binding pocket [chemical binding]; other site
357804002862	ferric uptake regulator; Provisional; Region: fur; PRK09462
357804002863	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
357804002864	metal binding site 2 [ion binding]; metal-binding site
357804002865	putative DNA binding helix; other site
357804002866	metal binding site 1 [ion binding]; metal-binding site
357804002867	dimer interface [polypeptide binding]; other site
357804002868	structural Zn2+ binding site [ion binding]; other site
357804002869	flavodoxin FldA; Validated; Region: PRK09267
357804002870	LexA regulated protein; Provisional; Region: PRK11675
357804002871	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
357804002872	acyl-CoA esterase; Provisional; Region: PRK10673
357804002873	PGAP1-like protein; Region: PGAP1; pfam07819
357804002874	SeqA protein; Region: SeqA; pfam03925
357804002875	phosphoglucomutase; Validated; Region: PRK07564
357804002876	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
357804002877	active site
357804002878	substrate binding site [chemical binding]; other site
357804002879	metal binding site [ion binding]; metal-binding site
357804002880	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
357804002881	homodimer interface [polypeptide binding]; other site
357804002882	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
357804002883	active site pocket [active]
357804002884	Protein of unknown function (DUF406); Region: DUF406; pfam04175
357804002885	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
357804002886	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
357804002887	ATP binding site [chemical binding]; other site
357804002888	putative Mg++ binding site [ion binding]; other site
357804002889	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804002890	nucleotide binding region [chemical binding]; other site
357804002891	ATP-binding site [chemical binding]; other site
357804002892	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
357804002893	HipA-like N-terminal domain; Region: HipA_N; pfam07805
357804002894	HipA-like C-terminal domain; Region: HipA_C; pfam07804
357804002895	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
357804002896	non-specific DNA binding site [nucleotide binding]; other site
357804002897	salt bridge; other site
357804002898	sequence-specific DNA binding site [nucleotide binding]; other site
357804002899	Predicted permeases [General function prediction only]; Region: COG0679
357804002900	Predicted permease [General function prediction only]; Region: COG2056
357804002901	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
357804002902	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
357804002903	DTW domain; Region: DTW; cl01221
357804002904	hypothetical protein; Provisional; Region: PRK09256
357804002905	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
357804002906	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
357804002907	dimer interface [polypeptide binding]; other site
357804002908	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
357804002909	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
357804002910	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
357804002911	active site
357804002912	catalytic site [active]
357804002913	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
357804002914	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
357804002915	metal binding site [ion binding]; metal-binding site
357804002916	dimer interface [polypeptide binding]; other site
357804002917	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
357804002918	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
357804002919	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
357804002920	catalytic site [active]
357804002921	subunit interface [polypeptide binding]; other site
357804002922	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
357804002923	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
357804002924	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
357804002925	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
357804002926	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
357804002927	ATP-grasp domain; Region: ATP-grasp_4; cl17255
357804002928	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
357804002929	IMP binding site; other site
357804002930	dimer interface [polypeptide binding]; other site
357804002931	interdomain contacts; other site
357804002932	partial ornithine binding site; other site
357804002933	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
357804002934	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
357804002935	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
357804002936	Competence protein; Region: Competence; pfam03772
357804002937	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
357804002938	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
357804002939	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
357804002940	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804002941	Walker A/P-loop; other site
357804002942	ATP binding site [chemical binding]; other site
357804002943	Q-loop/lid; other site
357804002944	ABC transporter signature motif; other site
357804002945	Walker B; other site
357804002946	D-loop; other site
357804002947	H-loop/switch region; other site
357804002948	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
357804002949	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
357804002950	Uncharacterized conserved protein [Function unknown]; Region: COG2835
357804002951	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
357804002952	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
357804002953	Ligand binding site; other site
357804002954	oligomer interface; other site
357804002955	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
357804002956	spermidine synthase; Provisional; Region: PRK03612
357804002957	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
357804002958	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
357804002959	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
357804002960	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
357804002961	GTP-binding protein YchF; Reviewed; Region: PRK09601
357804002962	YchF GTPase; Region: YchF; cd01900
357804002963	G1 box; other site
357804002964	GTP/Mg2+ binding site [chemical binding]; other site
357804002965	Switch I region; other site
357804002966	G2 box; other site
357804002967	Switch II region; other site
357804002968	G3 box; other site
357804002969	G4 box; other site
357804002970	G5 box; other site
357804002971	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
357804002972	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
357804002973	putative active site [active]
357804002974	catalytic residue [active]
357804002975	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
357804002976	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
357804002977	5S rRNA interface [nucleotide binding]; other site
357804002978	CTC domain interface [polypeptide binding]; other site
357804002979	L16 interface [polypeptide binding]; other site
357804002980	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
357804002981	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
357804002982	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
357804002983	active site
357804002984	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
357804002985	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
357804002986	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
357804002987	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
357804002988	recombination and repair protein; Provisional; Region: PRK10869
357804002989	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
357804002990	Walker A/P-loop; other site
357804002991	ATP binding site [chemical binding]; other site
357804002992	Q-loop/lid; other site
357804002993	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
357804002994	ABC transporter signature motif; other site
357804002995	Walker B; other site
357804002996	D-loop; other site
357804002997	H-loop/switch region; other site
357804002998	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
357804002999	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
357804003000	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
357804003001	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
357804003002	dimer interface [polypeptide binding]; other site
357804003003	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
357804003004	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
357804003005	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
357804003006	nucleotide binding site [chemical binding]; other site
357804003007	chaperone protein DnaJ; Provisional; Region: PRK10767
357804003008	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
357804003009	HSP70 interaction site [polypeptide binding]; other site
357804003010	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
357804003011	substrate binding site [polypeptide binding]; other site
357804003012	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
357804003013	Zn binding sites [ion binding]; other site
357804003014	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
357804003015	dimer interface [polypeptide binding]; other site
357804003016	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
357804003017	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
357804003018	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
357804003019	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
357804003020	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
357804003021	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
357804003022	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
357804003023	active site
357804003024	HIGH motif; other site
357804003025	dimer interface [polypeptide binding]; other site
357804003026	KMSKS motif; other site
357804003027	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
357804003028	RNA binding surface [nucleotide binding]; other site
357804003029	putative GTP cyclohydrolase; Provisional; Region: PRK13674
357804003030	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
357804003031	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804003032	putative active site [active]
357804003033	heme pocket [chemical binding]; other site
357804003034	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804003035	dimer interface [polypeptide binding]; other site
357804003036	phosphorylation site [posttranslational modification]
357804003037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804003038	ATP binding site [chemical binding]; other site
357804003039	Mg2+ binding site [ion binding]; other site
357804003040	G-X-G motif; other site
357804003041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804003042	active site
357804003043	phosphorylation site [posttranslational modification]
357804003044	intermolecular recognition site; other site
357804003045	dimerization interface [polypeptide binding]; other site
357804003046	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
357804003047	putative binding surface; other site
357804003048	active site
357804003049	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
357804003050	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
357804003051	tandem repeat interface [polypeptide binding]; other site
357804003052	oligomer interface [polypeptide binding]; other site
357804003053	active site residues [active]
357804003054	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
357804003055	Peptidase family M48; Region: Peptidase_M48; pfam01435
357804003056	SirA-like protein; Region: SirA; pfam01206
357804003057	CPxP  motif; other site
357804003058	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
357804003059	Domain of unknown function DUF20; Region: UPF0118; pfam01594
357804003060	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
357804003061	catalytic triad [active]
357804003062	universal stress protein UspE; Provisional; Region: PRK11175
357804003063	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
357804003064	Ligand Binding Site [chemical binding]; other site
357804003065	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
357804003066	Ligand Binding Site [chemical binding]; other site
357804003067	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
357804003068	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
357804003069	ligand binding site [chemical binding]; other site
357804003070	flexible hinge region; other site
357804003071	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
357804003072	putative switch regulator; other site
357804003073	non-specific DNA interactions [nucleotide binding]; other site
357804003074	DNA binding site [nucleotide binding]
357804003075	sequence specific DNA binding site [nucleotide binding]; other site
357804003076	putative cAMP binding site [chemical binding]; other site
357804003077	Family description; Region: DsbD_2; pfam13386
357804003078	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
357804003079	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
357804003080	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
357804003081	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
357804003082	metal-binding site [ion binding]
357804003083	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
357804003084	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
357804003085	FixH; Region: FixH; pfam05751
357804003086	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
357804003087	Cytochrome c; Region: Cytochrom_C; pfam00034
357804003088	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
357804003089	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
357804003090	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
357804003091	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
357804003092	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
357804003093	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
357804003094	Low-spin heme binding site [chemical binding]; other site
357804003095	Putative water exit pathway; other site
357804003096	Binuclear center (active site) [active]
357804003097	Putative proton exit pathway; other site
357804003098	Predicted membrane protein [Function unknown]; Region: COG2259
357804003099	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
357804003100	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
357804003101	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
357804003102	hypothetical protein; Provisional; Region: PRK05409
357804003103	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
357804003104	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
357804003105	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
357804003106	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
357804003107	DNA binding residues [nucleotide binding]
357804003108	Protein of unknown function (DUF3379); Region: DUF3379; pfam11859
357804003109	PAS fold; Region: PAS_3; pfam08447
357804003110	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804003111	heme pocket [chemical binding]; other site
357804003112	putative active site [active]
357804003113	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804003114	PAS domain; Region: PAS_9; pfam13426
357804003115	putative active site [active]
357804003116	heme pocket [chemical binding]; other site
357804003117	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804003118	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804003119	metal binding site [ion binding]; metal-binding site
357804003120	active site
357804003121	I-site; other site
357804003122	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804003123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
357804003124	TPR motif; other site
357804003125	binding surface
357804003126	short chain dehydrogenase; Provisional; Region: PRK09072
357804003127	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804003128	NAD(P) binding site [chemical binding]; other site
357804003129	active site
357804003130	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
357804003131	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914
357804003132	acyl-activating enzyme (AAE) consensus motif; other site
357804003133	putative AMP binding site [chemical binding]; other site
357804003134	putative active site [active]
357804003135	putative CoA binding site [chemical binding]; other site
357804003136	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
357804003137	heme binding pocket [chemical binding]; other site
357804003138	heme ligand [chemical binding]; other site
357804003139	Thermostable hemolysin; Region: T_hemolysin; pfam12261
357804003140	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
357804003141	Ligand Binding Site [chemical binding]; other site
357804003142	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
357804003143	Ligand Binding Site [chemical binding]; other site
357804003144	heat shock protein 90; Provisional; Region: PRK05218
357804003145	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804003146	ATP binding site [chemical binding]; other site
357804003147	Mg2+ binding site [ion binding]; other site
357804003148	G-X-G motif; other site
357804003149	adenylate kinase; Reviewed; Region: adk; PRK00279
357804003150	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
357804003151	AMP-binding site [chemical binding]; other site
357804003152	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
357804003153	NlpC/P60 family; Region: NLPC_P60; pfam00877
357804003154	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
357804003155	Ligand Binding Site [chemical binding]; other site
357804003156	Uncharacterized conserved protein [Function unknown]; Region: COG2850
357804003157	Cupin-like domain; Region: Cupin_8; pfam13621
357804003158	adenylosuccinate lyase; Provisional; Region: PRK09285
357804003159	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
357804003160	tetramer interface [polypeptide binding]; other site
357804003161	active site
357804003162	putative lysogenization regulator; Reviewed; Region: PRK00218
357804003163	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
357804003164	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
357804003165	putative transporter; Provisional; Region: PRK11660
357804003166	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
357804003167	Sulfate transporter family; Region: Sulfate_transp; pfam00916
357804003168	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
357804003169	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
357804003170	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
357804003171	ligand binding site [chemical binding]; other site
357804003172	flexible hinge region; other site
357804003173	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
357804003174	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
357804003175	metal binding triad; other site
357804003176	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
357804003177	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
357804003178	active site
357804003179	catalytic site [active]
357804003180	substrate binding site [chemical binding]; other site
357804003181	BCCT family transporter; Region: BCCT; pfam02028
357804003182	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
357804003183	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
357804003184	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
357804003185	putative substrate binding site [chemical binding]; other site
357804003186	putative ATP binding site [chemical binding]; other site
357804003187	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
357804003188	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
357804003189	active site turn [active]
357804003190	phosphorylation site [posttranslational modification]
357804003191	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
357804003192	Transcriptional regulators [Transcription]; Region: PurR; COG1609
357804003193	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804003194	DNA binding site [nucleotide binding]
357804003195	domain linker motif; other site
357804003196	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
357804003197	dimerization interface [polypeptide binding]; other site
357804003198	ligand binding site [chemical binding]; other site
357804003199	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
357804003200	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
357804003201	substrate binding [chemical binding]; other site
357804003202	active site
357804003203	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
357804003204	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
357804003205	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
357804003206	Walker A/P-loop; other site
357804003207	ATP binding site [chemical binding]; other site
357804003208	Q-loop/lid; other site
357804003209	ABC transporter signature motif; other site
357804003210	Walker B; other site
357804003211	D-loop; other site
357804003212	H-loop/switch region; other site
357804003213	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804003214	Walker A/P-loop; other site
357804003215	ATP binding site [chemical binding]; other site
357804003216	Q-loop/lid; other site
357804003217	ABC transporter signature motif; other site
357804003218	Walker B; other site
357804003219	D-loop; other site
357804003220	H-loop/switch region; other site
357804003221	Response regulator receiver domain; Region: Response_reg; pfam00072
357804003222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804003223	active site
357804003224	phosphorylation site [posttranslational modification]
357804003225	intermolecular recognition site; other site
357804003226	dimerization interface [polypeptide binding]; other site
357804003227	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804003228	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804003229	metal binding site [ion binding]; metal-binding site
357804003230	active site
357804003231	I-site; other site
357804003232	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
357804003233	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804003234	substrate binding pocket [chemical binding]; other site
357804003235	membrane-bound complex binding site; other site
357804003236	hinge residues; other site
357804003237	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
357804003238	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804003239	substrate binding pocket [chemical binding]; other site
357804003240	membrane-bound complex binding site; other site
357804003241	hinge residues; other site
357804003242	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
357804003243	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804003244	substrate binding pocket [chemical binding]; other site
357804003245	membrane-bound complex binding site; other site
357804003246	hinge residues; other site
357804003247	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
357804003248	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804003249	dimer interface [polypeptide binding]; other site
357804003250	phosphorylation site [posttranslational modification]
357804003251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804003252	ATP binding site [chemical binding]; other site
357804003253	Mg2+ binding site [ion binding]; other site
357804003254	G-X-G motif; other site
357804003255	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
357804003256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804003257	active site
357804003258	phosphorylation site [posttranslational modification]
357804003259	intermolecular recognition site; other site
357804003260	dimerization interface [polypeptide binding]; other site
357804003261	Response regulator receiver domain; Region: Response_reg; pfam00072
357804003262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804003263	active site
357804003264	phosphorylation site [posttranslational modification]
357804003265	intermolecular recognition site; other site
357804003266	dimerization interface [polypeptide binding]; other site
357804003267	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
357804003268	putative binding surface; other site
357804003269	active site
357804003270	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
357804003271	pseudouridine synthase; Region: TIGR00093
357804003272	active site
357804003273	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
357804003274	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
357804003275	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
357804003276	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
357804003277	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
357804003278	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
357804003279	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
357804003280	active site
357804003281	P-loop; other site
357804003282	phosphorylation site [posttranslational modification]
357804003283	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
357804003284	putative deacylase active site [active]
357804003285	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
357804003286	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
357804003287	dimerization interface [polypeptide binding]; other site
357804003288	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804003289	dimer interface [polypeptide binding]; other site
357804003290	phosphorylation site [posttranslational modification]
357804003291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804003292	ATP binding site [chemical binding]; other site
357804003293	Mg2+ binding site [ion binding]; other site
357804003294	G-X-G motif; other site
357804003295	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
357804003296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804003297	active site
357804003298	phosphorylation site [posttranslational modification]
357804003299	intermolecular recognition site; other site
357804003300	dimerization interface [polypeptide binding]; other site
357804003301	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
357804003302	DNA binding site [nucleotide binding]
357804003303	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
357804003304	classical (c) SDRs; Region: SDR_c; cd05233
357804003305	NAD(P) binding site [chemical binding]; other site
357804003306	active site
357804003307	SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; Region: SPARC_EC; cd00252
357804003308	EF-hand Ca2+ binding loops [ion binding]; other site
357804003309	FS-domain interface [polypeptide binding]; other site
357804003310	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
357804003311	Ca2+ binding site [ion binding]; other site
357804003312	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
357804003313	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
357804003314	RNA polymerase sigma factor; Provisional; Region: PRK11924
357804003315	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
357804003316	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
357804003317	DNA binding residues [nucleotide binding]
357804003318	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
357804003319	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
357804003320	Protein of unknown function (DUF523); Region: DUF523; pfam04463
357804003321	Uncharacterized conserved protein [Function unknown]; Region: COG3272
357804003322	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
357804003323	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
357804003324	DNA photolyase; Region: DNA_photolyase; pfam00875
357804003325	SnoaL-like domain; Region: SnoaL_2; pfam12680
357804003326	short chain dehydrogenase; Provisional; Region: PRK06101
357804003327	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804003328	NAD(P) binding site [chemical binding]; other site
357804003329	active site
357804003330	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
357804003331	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
357804003332	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
357804003333	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
357804003334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804003335	S-adenosylmethionine binding site [chemical binding]; other site
357804003336	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
357804003337	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
357804003338	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
357804003339	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
357804003340	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
357804003341	active site
357804003342	dimer interface [polypeptide binding]; other site
357804003343	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
357804003344	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
357804003345	active site
357804003346	FMN binding site [chemical binding]; other site
357804003347	substrate binding site [chemical binding]; other site
357804003348	3Fe-4S cluster binding site [ion binding]; other site
357804003349	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
357804003350	domain interface; other site
357804003351	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
357804003352	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
357804003353	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
357804003354	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
357804003355	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804003356	S-adenosylmethionine binding site [chemical binding]; other site
357804003357	LysE type translocator; Region: LysE; cl00565
357804003358	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
357804003359	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804003360	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
357804003361	dimerization interface [polypeptide binding]; other site
357804003362	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
357804003363	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804003364	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804003365	ABC transporter; Region: ABC_tran_2; pfam12848
357804003366	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804003367	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
357804003368	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
357804003369	acyl-activating enzyme (AAE) consensus motif; other site
357804003370	putative AMP binding site [chemical binding]; other site
357804003371	putative active site [active]
357804003372	putative CoA binding site [chemical binding]; other site
357804003373	Dodecin; Region: Dodecin; pfam07311
357804003374	hypothetical protein; Provisional; Region: PRK04946
357804003375	Smr domain; Region: Smr; pfam01713
357804003376	HemK family putative methylases; Region: hemK_fam; TIGR00536
357804003377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804003378	S-adenosylmethionine binding site [chemical binding]; other site
357804003379	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
357804003380	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
357804003381	Tetramer interface [polypeptide binding]; other site
357804003382	active site
357804003383	FMN-binding site [chemical binding]; other site
357804003384	AsmA family; Region: AsmA; pfam05170
357804003385	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
357804003386	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
357804003387	putative catalytic site [active]
357804003388	putative metal binding site [ion binding]; other site
357804003389	putative phosphate binding site [ion binding]; other site
357804003390	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
357804003391	active site
357804003392	Catalytic domain of Protein Kinases; Region: PKc; cd00180
357804003393	active site
357804003394	ATP binding site [chemical binding]; other site
357804003395	substrate binding site [chemical binding]; other site
357804003396	activation loop (A-loop); other site
357804003397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804003398	putative substrate translocation pore; other site
357804003399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804003400	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
357804003401	nitrite reductase subunit NirD; Provisional; Region: PRK14989
357804003402	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
357804003403	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
357804003404	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
357804003405	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
357804003406	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
357804003407	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
357804003408	active site
357804003409	SAM binding site [chemical binding]; other site
357804003410	homodimer interface [polypeptide binding]; other site
357804003411	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
357804003412	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
357804003413	[4Fe-4S] binding site [ion binding]; other site
357804003414	molybdopterin cofactor binding site; other site
357804003415	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
357804003416	molybdopterin cofactor binding site; other site
357804003417	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
357804003418	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
357804003419	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
357804003420	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
357804003421	putative active site [active]
357804003422	putative substrate binding site [chemical binding]; other site
357804003423	putative cosubstrate binding site; other site
357804003424	catalytic site [active]
357804003425	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
357804003426	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
357804003427	active sites [active]
357804003428	tetramer interface [polypeptide binding]; other site
357804003429	urocanate hydratase; Provisional; Region: PRK05414
357804003430	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
357804003431	putative active site [active]
357804003432	putative metal binding site [ion binding]; other site
357804003433	imidazolonepropionase; Validated; Region: PRK09356
357804003434	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
357804003435	active site
357804003436	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
357804003437	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804003438	DNA-binding site [nucleotide binding]; DNA binding site
357804003439	UTRA domain; Region: UTRA; pfam07702
357804003440	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
357804003441	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
357804003442	active site
357804003443	Zn binding site [ion binding]; other site
357804003444	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
357804003445	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
357804003446	NADP binding site [chemical binding]; other site
357804003447	dimer interface [polypeptide binding]; other site
357804003448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804003449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804003450	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
357804003451	substrate binding pocket [chemical binding]; other site
357804003452	dimerization interface [polypeptide binding]; other site
357804003453	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
357804003454	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
357804003455	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
357804003456	protein binding site [polypeptide binding]; other site
357804003457	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
357804003458	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
357804003459	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
357804003460	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
357804003461	HSP70 interaction site [polypeptide binding]; other site
357804003462	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
357804003463	substrate binding site [polypeptide binding]; other site
357804003464	dimer interface [polypeptide binding]; other site
357804003465	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
357804003466	Clp amino terminal domain; Region: Clp_N; pfam02861
357804003467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804003468	Walker A motif; other site
357804003469	ATP binding site [chemical binding]; other site
357804003470	Walker B motif; other site
357804003471	arginine finger; other site
357804003472	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804003473	Walker A motif; other site
357804003474	ATP binding site [chemical binding]; other site
357804003475	Walker B motif; other site
357804003476	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
357804003477	hypothetical protein; Provisional; Region: PRK03757
357804003478	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
357804003479	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
357804003480	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
357804003481	putative GSH binding site (G-site) [chemical binding]; other site
357804003482	active site cysteine [active]
357804003483	putative C-terminal domain interface [polypeptide binding]; other site
357804003484	putative dimer interface [polypeptide binding]; other site
357804003485	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
357804003486	putative N-terminal domain interface [polypeptide binding]; other site
357804003487	putative dimer interface [polypeptide binding]; other site
357804003488	putative substrate binding pocket (H-site) [chemical binding]; other site
357804003489	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
357804003490	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
357804003491	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
357804003492	folate binding site [chemical binding]; other site
357804003493	NADP+ binding site [chemical binding]; other site
357804003494	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
357804003495	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
357804003496	active site
357804003497	metal binding site [ion binding]; metal-binding site
357804003498	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
357804003499	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
357804003500	S-adenosylmethionine binding site [chemical binding]; other site
357804003501	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
357804003502	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
357804003503	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
357804003504	SurA N-terminal domain; Region: SurA_N; pfam09312
357804003505	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
357804003506	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
357804003507	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
357804003508	OstA-like protein; Region: OstA; cl00844
357804003509	Organic solvent tolerance protein; Region: OstA_C; pfam04453
357804003510	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
357804003511	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
357804003512	putative metal binding site [ion binding]; other site
357804003513	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
357804003514	HSP70 interaction site [polypeptide binding]; other site
357804003515	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
357804003516	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
357804003517	putative trimer interface [polypeptide binding]; other site
357804003518	putative CoA binding site [chemical binding]; other site
357804003519	YciI-like protein; Reviewed; Region: PRK11370
357804003520	intracellular septation protein A; Reviewed; Region: PRK00259
357804003521	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
357804003522	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
357804003523	substrate binding site [chemical binding]; other site
357804003524	active site
357804003525	catalytic residues [active]
357804003526	heterodimer interface [polypeptide binding]; other site
357804003527	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
357804003528	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
357804003529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804003530	catalytic residue [active]
357804003531	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
357804003532	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
357804003533	active site
357804003534	ribulose/triose binding site [chemical binding]; other site
357804003535	phosphate binding site [ion binding]; other site
357804003536	substrate (anthranilate) binding pocket [chemical binding]; other site
357804003537	product (indole) binding pocket [chemical binding]; other site
357804003538	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
357804003539	active site
357804003540	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
357804003541	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
357804003542	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
357804003543	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
357804003544	Glutamine amidotransferase class-I; Region: GATase; pfam00117
357804003545	glutamine binding [chemical binding]; other site
357804003546	catalytic triad [active]
357804003547	anthranilate synthase component I; Provisional; Region: PRK13564
357804003548	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
357804003549	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
357804003550	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
357804003551	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
357804003552	active site
357804003553	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
357804003554	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
357804003555	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
357804003556	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
357804003557	RNA binding surface [nucleotide binding]; other site
357804003558	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
357804003559	probable active site [active]
357804003560	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
357804003561	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
357804003562	active site
357804003563	tetramer interface; other site
357804003564	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
357804003565	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
357804003566	putative active site [active]
357804003567	LrgA family; Region: LrgA; cl00608
357804003568	LrgB-like family; Region: LrgB; cl00596
357804003569	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
357804003570	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
357804003571	active site
357804003572	substrate binding site [chemical binding]; other site
357804003573	cosubstrate binding site; other site
357804003574	catalytic site [active]
357804003575	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
357804003576	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
357804003577	dimerization interface [polypeptide binding]; other site
357804003578	putative ATP binding site [chemical binding]; other site
357804003579	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
357804003580	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
357804003581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804003582	Walker A motif; other site
357804003583	ATP binding site [chemical binding]; other site
357804003584	Walker B motif; other site
357804003585	arginine finger; other site
357804003586	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
357804003587	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
357804003588	ArsC family; Region: ArsC; pfam03960
357804003589	catalytic residues [active]
357804003590	hypothetical protein; Provisional; Region: PRK05170
357804003591	Transglycosylase SLT domain; Region: SLT_2; pfam13406
357804003592	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
357804003593	N-acetyl-D-glucosamine binding site [chemical binding]; other site
357804003594	catalytic residue [active]
357804003595	YcgL domain; Region: YcgL; pfam05166
357804003596	septum formation inhibitor; Reviewed; Region: minC; PRK04804
357804003597	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
357804003598	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
357804003599	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
357804003600	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
357804003601	Switch I; other site
357804003602	Switch II; other site
357804003603	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
357804003604	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
357804003605	active site
357804003606	hypothetical protein; Provisional; Region: PRK11627
357804003607	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
357804003608	excinuclease ABC subunit B; Provisional; Region: PRK05298
357804003609	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804003610	ATP binding site [chemical binding]; other site
357804003611	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804003612	nucleotide binding region [chemical binding]; other site
357804003613	ATP-binding site [chemical binding]; other site
357804003614	Ultra-violet resistance protein B; Region: UvrB; pfam12344
357804003615	UvrB/uvrC motif; Region: UVR; pfam02151
357804003616	Maf-like protein; Region: Maf; pfam02545
357804003617	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
357804003618	active site
357804003619	dimer interface [polypeptide binding]; other site
357804003620	hypothetical protein; Provisional; Region: PRK11193
357804003621	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
357804003622	putative phosphate acyltransferase; Provisional; Region: PRK05331
357804003623	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
357804003624	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
357804003625	dimer interface [polypeptide binding]; other site
357804003626	active site
357804003627	CoA binding pocket [chemical binding]; other site
357804003628	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
357804003629	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
357804003630	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
357804003631	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
357804003632	NAD(P) binding site [chemical binding]; other site
357804003633	homotetramer interface [polypeptide binding]; other site
357804003634	homodimer interface [polypeptide binding]; other site
357804003635	active site
357804003636	acyl carrier protein; Provisional; Region: acpP; PRK00982
357804003637	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
357804003638	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
357804003639	dimer interface [polypeptide binding]; other site
357804003640	active site
357804003641	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
357804003642	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
357804003643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804003644	catalytic residue [active]
357804003645	YceG-like family; Region: YceG; pfam02618
357804003646	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
357804003647	dimerization interface [polypeptide binding]; other site
357804003648	thymidylate kinase; Validated; Region: tmk; PRK00698
357804003649	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
357804003650	TMP-binding site; other site
357804003651	ATP-binding site [chemical binding]; other site
357804003652	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
357804003653	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
357804003654	active site
357804003655	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804003656	DNA-binding site [nucleotide binding]; DNA binding site
357804003657	RNA-binding motif; other site
357804003658	Predicted ATPase [General function prediction only]; Region: COG3911
357804003659	AAA domain; Region: AAA_28; pfam13521
357804003660	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
357804003661	Ligand Binding Site [chemical binding]; other site
357804003662	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
357804003663	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
357804003664	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
357804003665	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804003666	ATP binding site [chemical binding]; other site
357804003667	putative Mg++ binding site [ion binding]; other site
357804003668	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804003669	nucleotide binding region [chemical binding]; other site
357804003670	ATP-binding site [chemical binding]; other site
357804003671	Helicase associated domain (HA2); Region: HA2; pfam04408
357804003672	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
357804003673	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
357804003674	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
357804003675	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
357804003676	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
357804003677	putative active site [active]
357804003678	putative substrate binding site [chemical binding]; other site
357804003679	putative cosubstrate binding site; other site
357804003680	catalytic site [active]
357804003681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
357804003682	SEC-C motif; Region: SEC-C; pfam02810
357804003683	asparagine synthetase B; Provisional; Region: asnB; PRK09431
357804003684	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
357804003685	active site
357804003686	dimer interface [polypeptide binding]; other site
357804003687	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
357804003688	Ligand Binding Site [chemical binding]; other site
357804003689	Molecular Tunnel; other site
357804003690	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
357804003691	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
357804003692	TrkA-N domain; Region: TrkA_N; pfam02254
357804003693	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
357804003694	Sel1-like repeats; Region: SEL1; smart00671
357804003695	Sel1-like repeats; Region: SEL1; smart00671
357804003696	Sel1-like repeats; Region: SEL1; smart00671
357804003697	Sel1-like repeats; Region: SEL1; smart00671
357804003698	Sel1-like repeats; Region: SEL1; smart00671
357804003699	Sel1-like repeats; Region: SEL1; smart00671
357804003700	Sel1-like repeats; Region: SEL1; smart00671
357804003701	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
357804003702	catalytic loop [active]
357804003703	iron binding site [ion binding]; other site
357804003704	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
357804003705	dimer interface [polypeptide binding]; other site
357804003706	putative radical transfer pathway; other site
357804003707	diiron center [ion binding]; other site
357804003708	tyrosyl radical; other site
357804003709	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
357804003710	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
357804003711	ligand binding site [chemical binding]; other site
357804003712	HAMP domain; Region: HAMP; pfam00672
357804003713	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804003714	PAS fold; Region: PAS_3; pfam08447
357804003715	putative active site [active]
357804003716	heme pocket [chemical binding]; other site
357804003717	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804003718	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804003719	metal binding site [ion binding]; metal-binding site
357804003720	active site
357804003721	I-site; other site
357804003722	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804003723	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
357804003724	ATP cone domain; Region: ATP-cone; pfam03477
357804003725	Class I ribonucleotide reductase; Region: RNR_I; cd01679
357804003726	active site
357804003727	dimer interface [polypeptide binding]; other site
357804003728	catalytic residues [active]
357804003729	effector binding site; other site
357804003730	R2 peptide binding site; other site
357804003731	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
357804003732	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804003733	S-adenosylmethionine binding site [chemical binding]; other site
357804003734	DNA gyrase subunit A; Validated; Region: PRK05560
357804003735	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
357804003736	CAP-like domain; other site
357804003737	active site
357804003738	primary dimer interface [polypeptide binding]; other site
357804003739	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
357804003740	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
357804003741	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
357804003742	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
357804003743	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
357804003744	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
357804003745	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
357804003746	homodimer interface [polypeptide binding]; other site
357804003747	substrate-cofactor binding pocket; other site
357804003748	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804003749	catalytic residue [active]
357804003750	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
357804003751	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
357804003752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804003753	homodimer interface [polypeptide binding]; other site
357804003754	catalytic residue [active]
357804003755	3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338
357804003756	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
357804003757	hinge; other site
357804003758	active site
357804003759	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
357804003760	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
357804003761	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804003762	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804003763	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804003764	metal binding site [ion binding]; metal-binding site
357804003765	active site
357804003766	I-site; other site
357804003767	rod shape-determining protein MreB; Provisional; Region: PRK13927
357804003768	MreB and similar proteins; Region: MreB_like; cd10225
357804003769	nucleotide binding site [chemical binding]; other site
357804003770	Mg binding site [ion binding]; other site
357804003771	putative protofilament interaction site [polypeptide binding]; other site
357804003772	RodZ interaction site [polypeptide binding]; other site
357804003773	rod shape-determining protein MreC; Region: mreC; TIGR00219
357804003774	rod shape-determining protein MreC; Region: MreC; pfam04085
357804003775	rod shape-determining protein MreD; Region: MreD; cl01087
357804003776	Maf-like protein; Region: Maf; pfam02545
357804003777	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
357804003778	active site
357804003779	dimer interface [polypeptide binding]; other site
357804003780	ribonuclease G; Provisional; Region: PRK11712
357804003781	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
357804003782	homodimer interface [polypeptide binding]; other site
357804003783	oligonucleotide binding site [chemical binding]; other site
357804003784	TIGR02099 family protein; Region: TIGR02099
357804003785	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
357804003786	Predicted amidohydrolase [General function prediction only]; Region: COG0388
357804003787	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
357804003788	putative active site [active]
357804003789	catalytic triad [active]
357804003790	dimer interface [polypeptide binding]; other site
357804003791	protease TldD; Provisional; Region: tldD; PRK10735
357804003792	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
357804003793	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
357804003794	Protein of unknown function (DUF615); Region: DUF615; pfam04751
357804003795	peptidase PmbA; Provisional; Region: PRK11040
357804003796	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
357804003797	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
357804003798	Sporulation related domain; Region: SPOR; pfam05036
357804003799	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
357804003800	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
357804003801	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
357804003802	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
357804003803	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
357804003804	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
357804003805	cell division protein MraZ; Reviewed; Region: PRK00326
357804003806	MraZ protein; Region: MraZ; pfam02381
357804003807	MraZ protein; Region: MraZ; pfam02381
357804003808	MraW methylase family; Region: Methyltransf_5; pfam01795
357804003809	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
357804003810	Cell division protein FtsL; Region: FtsL; pfam04999
357804003811	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
357804003812	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
357804003813	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
357804003814	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
357804003815	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
357804003816	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
357804003817	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
357804003818	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
357804003819	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
357804003820	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
357804003821	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
357804003822	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
357804003823	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
357804003824	Mg++ binding site [ion binding]; other site
357804003825	putative catalytic motif [active]
357804003826	putative substrate binding site [chemical binding]; other site
357804003827	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
357804003828	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
357804003829	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
357804003830	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
357804003831	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
357804003832	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
357804003833	active site
357804003834	homodimer interface [polypeptide binding]; other site
357804003835	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
357804003836	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
357804003837	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
357804003838	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
357804003839	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
357804003840	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
357804003841	ATP-grasp domain; Region: ATP-grasp_4; cl17255
357804003842	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
357804003843	Cell division protein FtsQ; Region: FtsQ; pfam03799
357804003844	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
357804003845	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
357804003846	nucleotide binding site [chemical binding]; other site
357804003847	Cell division protein FtsA; Region: FtsA; pfam14450
357804003848	cell division protein FtsZ; Validated; Region: PRK09330
357804003849	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
357804003850	nucleotide binding site [chemical binding]; other site
357804003851	SulA interaction site; other site
357804003852	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
357804003853	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
357804003854	Protein of unknown function (DUF721); Region: DUF721; cl02324
357804003855	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
357804003856	DEAD/DEAH box helicase; Region: DEAD; pfam00270
357804003857	ATP binding site [chemical binding]; other site
357804003858	putative Mg++ binding site [ion binding]; other site
357804003859	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
357804003860	SEC-C motif; Region: SEC-C; pfam02810
357804003861	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
357804003862	active site
357804003863	8-oxo-dGMP binding site [chemical binding]; other site
357804003864	nudix motif; other site
357804003865	metal binding site [ion binding]; metal-binding site
357804003866	DNA ligase; Provisional; Region: PRK09125
357804003867	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
357804003868	DNA binding site [nucleotide binding]
357804003869	active site
357804003870	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
357804003871	DNA binding site [nucleotide binding]
357804003872	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
357804003873	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
357804003874	dimerization interface [polypeptide binding]; other site
357804003875	active site
357804003876	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
357804003877	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
357804003878	CoA-binding site [chemical binding]; other site
357804003879	hypothetical protein; Provisional; Region: PRK05287
357804003880	Domain of unknown function (DUF329); Region: DUF329; pfam03884
357804003881	translation initiation factor Sui1; Validated; Region: PRK06824
357804003882	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
357804003883	putative rRNA binding site [nucleotide binding]; other site
357804003884	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
357804003885	Helix-turn-helix domain; Region: HTH_38; pfam13936
357804003886	Homeodomain-like domain; Region: HTH_32; pfam13565
357804003887	Integrase core domain; Region: rve; pfam00665
357804003888	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
357804003889	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804003890	FeS/SAM binding site; other site
357804003891	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804003892	binding surface
357804003893	TPR motif; other site
357804003894	TPR repeat; Region: TPR_11; pfam13414
357804003895	Tetratricopeptide repeat; Region: TPR_12; pfam13424
357804003896	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
357804003897	Helix-turn-helix domain; Region: HTH_25; pfam13413
357804003898	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
357804003899	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
357804003900	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
357804003901	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
357804003902	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
357804003903	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
357804003904	dimer interface [polypeptide binding]; other site
357804003905	motif 1; other site
357804003906	active site
357804003907	motif 2; other site
357804003908	motif 3; other site
357804003909	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
357804003910	anticodon binding site; other site
357804003911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
357804003912	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
357804003913	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804003914	binding surface
357804003915	TPR motif; other site
357804003916	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
357804003917	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
357804003918	Trp docking motif [polypeptide binding]; other site
357804003919	GTP-binding protein Der; Reviewed; Region: PRK00093
357804003920	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
357804003921	G1 box; other site
357804003922	GTP/Mg2+ binding site [chemical binding]; other site
357804003923	Switch I region; other site
357804003924	G2 box; other site
357804003925	Switch II region; other site
357804003926	G3 box; other site
357804003927	G4 box; other site
357804003928	G5 box; other site
357804003929	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
357804003930	G1 box; other site
357804003931	GTP/Mg2+ binding site [chemical binding]; other site
357804003932	Switch I region; other site
357804003933	G2 box; other site
357804003934	G3 box; other site
357804003935	Switch II region; other site
357804003936	G4 box; other site
357804003937	G5 box; other site
357804003938	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
357804003939	outer membrane lipoprotein; Provisional; Region: PRK11023
357804003940	BON domain; Region: BON; pfam04972
357804003941	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
357804003942	dimer interface [polypeptide binding]; other site
357804003943	active site
357804003944	hypothetical protein; Reviewed; Region: PRK12497
357804003945	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
357804003946	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
357804003947	putative ligand binding site [chemical binding]; other site
357804003948	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
357804003949	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
357804003950	putative SAM binding site [chemical binding]; other site
357804003951	putative homodimer interface [polypeptide binding]; other site
357804003952	Acyltransferase family; Region: Acyl_transf_3; pfam01757
357804003953	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
357804003954	multiple promoter invertase; Provisional; Region: mpi; PRK13413
357804003955	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
357804003956	catalytic residues [active]
357804003957	catalytic nucleophile [active]
357804003958	Transposase; Region: HTH_Tnp_1; pfam01527
357804003959	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
357804003960	HTH-like domain; Region: HTH_21; pfam13276
357804003961	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
357804003962	Integrase core domain; Region: rve; pfam00665
357804003963	Integrase core domain; Region: rve_3; pfam13683
357804003964	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
357804003965	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
357804003966	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
357804003967	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
357804003968	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
357804003969	active site
357804003970	(T/H)XGH motif; other site
357804003971	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
357804003972	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
357804003973	Lipopolysaccharide-assembly; Region: LptE; cl01125
357804003974	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
357804003975	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
357804003976	HIGH motif; other site
357804003977	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
357804003978	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
357804003979	active site
357804003980	KMSKS motif; other site
357804003981	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
357804003982	tRNA binding surface [nucleotide binding]; other site
357804003983	response regulator; Provisional; Region: PRK09483
357804003984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804003985	active site
357804003986	phosphorylation site [posttranslational modification]
357804003987	intermolecular recognition site; other site
357804003988	dimerization interface [polypeptide binding]; other site
357804003989	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
357804003990	DNA binding residues [nucleotide binding]
357804003991	dimerization interface [polypeptide binding]; other site
357804003992	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
357804003993	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
357804003994	GIY-YIG motif/motif A; other site
357804003995	active site
357804003996	catalytic site [active]
357804003997	putative DNA binding site [nucleotide binding]; other site
357804003998	metal binding site [ion binding]; metal-binding site
357804003999	UvrB/uvrC motif; Region: UVR; pfam02151
357804004000	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
357804004001	Helix-hairpin-helix motif; Region: HHH; pfam00633
357804004002	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
357804004003	two-component response regulator; Provisional; Region: PRK11173
357804004004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804004005	active site
357804004006	phosphorylation site [posttranslational modification]
357804004007	intermolecular recognition site; other site
357804004008	dimerization interface [polypeptide binding]; other site
357804004009	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
357804004010	DNA binding site [nucleotide binding]
357804004011	Predicted membrane protein [Function unknown]; Region: COG2261
357804004012	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804004013	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004014	I-site; other site
357804004015	active site
357804004016	metal binding site [ion binding]; metal-binding site
357804004017	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
357804004018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804004019	putative active site [active]
357804004020	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
357804004021	heme pocket [chemical binding]; other site
357804004022	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804004023	putative active site [active]
357804004024	heme pocket [chemical binding]; other site
357804004025	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804004026	putative active site [active]
357804004027	heme pocket [chemical binding]; other site
357804004028	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004029	metal binding site [ion binding]; metal-binding site
357804004030	active site
357804004031	I-site; other site
357804004032	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804004033	PAS fold; Region: PAS_4; pfam08448
357804004034	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804004035	putative active site [active]
357804004036	heme pocket [chemical binding]; other site
357804004037	GAF domain; Region: GAF; pfam01590
357804004038	GAF domain; Region: GAF_2; pfam13185
357804004039	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804004040	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004041	metal binding site [ion binding]; metal-binding site
357804004042	active site
357804004043	I-site; other site
357804004044	FIST N domain; Region: FIST; pfam08495
357804004045	FIST C domain; Region: FIST_C; pfam10442
357804004046	PAS domain; Region: PAS_9; pfam13426
357804004047	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804004048	putative active site [active]
357804004049	heme pocket [chemical binding]; other site
357804004050	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804004051	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004052	metal binding site [ion binding]; metal-binding site
357804004053	active site
357804004054	I-site; other site
357804004055	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804004056	FIST N domain; Region: FIST; pfam08495
357804004057	FIST C domain; Region: FIST_C; pfam10442
357804004058	PAS domain; Region: PAS_9; pfam13426
357804004059	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804004060	putative active site [active]
357804004061	heme pocket [chemical binding]; other site
357804004062	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804004063	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004064	metal binding site [ion binding]; metal-binding site
357804004065	active site
357804004066	I-site; other site
357804004067	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804004068	FIST N domain; Region: FIST; pfam08495
357804004069	FIST C domain; Region: FIST_C; pfam10442
357804004070	PAS domain; Region: PAS_9; pfam13426
357804004071	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804004072	putative active site [active]
357804004073	heme pocket [chemical binding]; other site
357804004074	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804004075	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004076	metal binding site [ion binding]; metal-binding site
357804004077	active site
357804004078	I-site; other site
357804004079	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804004080	PAS domain S-box; Region: sensory_box; TIGR00229
357804004081	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804004082	putative active site [active]
357804004083	heme pocket [chemical binding]; other site
357804004084	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804004085	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004086	metal binding site [ion binding]; metal-binding site
357804004087	active site
357804004088	I-site; other site
357804004089	Protein of unknown function (DUF523); Region: DUF523; pfam04463
357804004090	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
357804004091	Hydrogenase formation hypA family; Region: HypD; pfam01924
357804004092	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
357804004093	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
357804004094	substrate binding site [chemical binding]; other site
357804004095	oxyanion hole (OAH) forming residues; other site
357804004096	trimer interface [polypeptide binding]; other site
357804004097	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
357804004098	active site
357804004099	substrate binding site [chemical binding]; other site
357804004100	cosubstrate binding site; other site
357804004101	catalytic site [active]
357804004102	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
357804004103	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
357804004104	dimerization interface [polypeptide binding]; other site
357804004105	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
357804004106	ATP binding site [chemical binding]; other site
357804004107	HupF/HypC family; Region: HupF_HypC; pfam01455
357804004108	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
357804004109	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
357804004110	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
357804004111	nickel binding site [ion binding]; other site
357804004112	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
357804004113	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
357804004114	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
357804004115	catalytic loop [active]
357804004116	iron binding site [ion binding]; other site
357804004117	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
357804004118	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
357804004119	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
357804004120	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
357804004121	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
357804004122	SLBB domain; Region: SLBB; pfam10531
357804004123	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
357804004124	Acylphosphatase; Region: Acylphosphatase; pfam00708
357804004125	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
357804004126	HypF finger; Region: zf-HYPF; pfam07503
357804004127	HypF finger; Region: zf-HYPF; pfam07503
357804004128	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
357804004129	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
357804004130	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
357804004131	Nitrogen regulatory protein P-II; Region: P-II; smart00938
357804004132	FOG: CBS domain [General function prediction only]; Region: COG0517
357804004133	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
357804004134	Protein required for attachment to host cells; Region: Host_attach; pfam10116
357804004135	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
357804004136	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
357804004137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804004138	active site
357804004139	phosphorylation site [posttranslational modification]
357804004140	intermolecular recognition site; other site
357804004141	dimerization interface [polypeptide binding]; other site
357804004142	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
357804004143	DNA binding site [nucleotide binding]
357804004144	sensor protein QseC; Provisional; Region: PRK10337
357804004145	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804004146	phosphorylation site [posttranslational modification]
357804004147	dimer interface [polypeptide binding]; other site
357804004148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804004149	ATP binding site [chemical binding]; other site
357804004150	Mg2+ binding site [ion binding]; other site
357804004151	G-X-G motif; other site
357804004152	EamA-like transporter family; Region: EamA; pfam00892
357804004153	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
357804004154	EamA-like transporter family; Region: EamA; pfam00892
357804004155	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
357804004156	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
357804004157	nucleotide binding site [chemical binding]; other site
357804004158	putative NEF/HSP70 interaction site [polypeptide binding]; other site
357804004159	SBD interface [polypeptide binding]; other site
357804004160	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
357804004161	nucleotide binding site [chemical binding]; other site
357804004162	putative NEF/HSP70 interaction site [polypeptide binding]; other site
357804004163	SBD interface [polypeptide binding]; other site
357804004164	DNA-K related protein; Region: DUF3731; pfam12531
357804004165	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
357804004166	Ligand Binding Site [chemical binding]; other site
357804004167	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
357804004168	CHAP domain; Region: CHAP; pfam05257
357804004169	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
357804004170	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
357804004171	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
357804004172	Zn2+ binding site [ion binding]; other site
357804004173	Mg2+ binding site [ion binding]; other site
357804004174	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
357804004175	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
357804004176	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804004177	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004178	metal binding site [ion binding]; metal-binding site
357804004179	active site
357804004180	I-site; other site
357804004181	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804004182	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
357804004183	transmembrane helices; other site
357804004184	TrkA-C domain; Region: TrkA_C; pfam02080
357804004185	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
357804004186	TrkA-C domain; Region: TrkA_C; pfam02080
357804004187	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
357804004188	azoreductase; Reviewed; Region: PRK00170
357804004189	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
357804004190	hypothetical protein; Provisional; Region: PRK02487
357804004191	putative oxidoreductase; Provisional; Region: PRK11579
357804004192	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
357804004193	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
357804004194	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
357804004195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804004196	active site
357804004197	phosphorylation site [posttranslational modification]
357804004198	intermolecular recognition site; other site
357804004199	dimerization interface [polypeptide binding]; other site
357804004200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804004201	Walker A motif; other site
357804004202	ATP binding site [chemical binding]; other site
357804004203	Walker B motif; other site
357804004204	arginine finger; other site
357804004205	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
357804004206	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
357804004207	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
357804004208	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
357804004209	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
357804004210	Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933
357804004211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804004212	Walker A motif; other site
357804004213	ATP binding site [chemical binding]; other site
357804004214	Walker B motif; other site
357804004215	arginine finger; other site
357804004216	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804004217	ATP binding site [chemical binding]; other site
357804004218	Walker B motif; other site
357804004219	arginine finger; other site
357804004220	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
357804004221	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
357804004222	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804004223	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
357804004224	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804004225	putative active site [active]
357804004226	heme pocket [chemical binding]; other site
357804004227	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804004228	dimer interface [polypeptide binding]; other site
357804004229	phosphorylation site [posttranslational modification]
357804004230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804004231	ATP binding site [chemical binding]; other site
357804004232	Mg2+ binding site [ion binding]; other site
357804004233	G-X-G motif; other site
357804004234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804004235	Response regulator receiver domain; Region: Response_reg; pfam00072
357804004236	active site
357804004237	phosphorylation site [posttranslational modification]
357804004238	intermolecular recognition site; other site
357804004239	dimerization interface [polypeptide binding]; other site
357804004240	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
357804004241	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
357804004242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804004243	Walker A motif; other site
357804004244	ATP binding site [chemical binding]; other site
357804004245	Walker B motif; other site
357804004246	arginine finger; other site
357804004247	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
357804004248	Gas vesicle protein; Region: Gas_vesicle; pfam00741
357804004249	Gas vesicle protein K; Region: GvpK; pfam05121
357804004250	Gas vesicle protein; Region: Gas_vesicle; pfam00741
357804004251	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
357804004252	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
357804004253	putative metal binding site [ion binding]; other site
357804004254	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
357804004255	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
357804004256	putative metal binding site [ion binding]; other site
357804004257	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
357804004258	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
357804004259	putative metal binding site [ion binding]; other site
357804004260	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
357804004261	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
357804004262	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
357804004263	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
357804004264	active site
357804004265	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
357804004266	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
357804004267	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
357804004268	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
357804004269	tellurite resistance protein terB; Region: terB; cd07176
357804004270	putative metal binding site [ion binding]; other site
357804004271	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
357804004272	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
357804004273	putative catalytic residues [active]
357804004274	putative nucleotide binding site [chemical binding]; other site
357804004275	putative aspartate binding site [chemical binding]; other site
357804004276	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
357804004277	dimer interface [polypeptide binding]; other site
357804004278	putative threonine allosteric regulatory site; other site
357804004279	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
357804004280	putative threonine allosteric regulatory site; other site
357804004281	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
357804004282	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
357804004283	homoserine kinase; Provisional; Region: PRK01212
357804004284	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
357804004285	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
357804004286	threonine synthase; Validated; Region: PRK09225
357804004287	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
357804004288	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
357804004289	catalytic residue [active]
357804004290	acyl-CoA thioesterase II; Provisional; Region: PRK10526
357804004291	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
357804004292	active site
357804004293	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
357804004294	catalytic triad [active]
357804004295	dimer interface [polypeptide binding]; other site
357804004296	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
357804004297	autonomous glycyl radical cofactor GrcA; Region: spare_glycyl; TIGR04365
357804004298	autonomous glycyl radical cofactor GrcA; Region: spare_glycyl; TIGR04365
357804004299	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
357804004300	ligand binding site [chemical binding]; other site
357804004301	active site
357804004302	UGI interface [polypeptide binding]; other site
357804004303	catalytic site [active]
357804004304	Hemerythrin family; Region: Hemerythrin-like; cl15774
357804004305	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
357804004306	hypothetical protein; Validated; Region: PRK00228
357804004307	glutathione synthetase; Provisional; Region: PRK05246
357804004308	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
357804004309	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
357804004310	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
357804004311	RNA methyltransferase, RsmE family; Region: TIGR00046
357804004312	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
357804004313	FAD binding site [chemical binding]; other site
357804004314	Uncharacterized conserved protein [Function unknown]; Region: COG2966
357804004315	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
357804004316	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
357804004317	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
357804004318	SEC-C motif; Region: SEC-C; pfam02810
357804004319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
357804004320	Domain of unknown function (DUF2431); Region: DUF2431; pfam10354
357804004321	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
357804004322	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804004323	ATP binding site [chemical binding]; other site
357804004324	putative Mg++ binding site [ion binding]; other site
357804004325	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804004326	nucleotide binding region [chemical binding]; other site
357804004327	ATP-binding site [chemical binding]; other site
357804004328	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
357804004329	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
357804004330	ligand binding site; other site
357804004331	oligomer interface; other site
357804004332	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
357804004333	dimer interface [polypeptide binding]; other site
357804004334	N-terminal domain interface [polypeptide binding]; other site
357804004335	sulfate 1 binding site; other site
357804004336	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
357804004337	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
357804004338	ligand binding site [chemical binding]; other site
357804004339	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
357804004340	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
357804004341	Walker A/P-loop; other site
357804004342	ATP binding site [chemical binding]; other site
357804004343	Q-loop/lid; other site
357804004344	ABC transporter signature motif; other site
357804004345	Walker B; other site
357804004346	D-loop; other site
357804004347	H-loop/switch region; other site
357804004348	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
357804004349	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
357804004350	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
357804004351	TM-ABC transporter signature motif; other site
357804004352	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
357804004353	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
357804004354	TM-ABC transporter signature motif; other site
357804004355	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
357804004356	Peptidase family U32; Region: Peptidase_U32; pfam01136
357804004357	Collagenase; Region: DUF3656; pfam12392
357804004358	Peptidase family U32; Region: Peptidase_U32; cl03113
357804004359	exonuclease subunit SbcD; Provisional; Region: PRK10966
357804004360	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
357804004361	active site
357804004362	metal binding site [ion binding]; metal-binding site
357804004363	DNA binding site [nucleotide binding]
357804004364	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
357804004365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804004366	AAA domain; Region: AAA_23; pfam13476
357804004367	Walker A/P-loop; other site
357804004368	ATP binding site [chemical binding]; other site
357804004369	Q-loop/lid; other site
357804004370	exonuclease subunit SbcC; Provisional; Region: PRK10246
357804004371	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
357804004372	Q-loop/lid; other site
357804004373	ABC transporter signature motif; other site
357804004374	Walker B; other site
357804004375	D-loop; other site
357804004376	H-loop/switch region; other site
357804004377	PBP superfamily domain; Region: PBP_like_2; cl17296
357804004378	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804004379	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004380	metal binding site [ion binding]; metal-binding site
357804004381	active site
357804004382	I-site; other site
357804004383	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
357804004384	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
357804004385	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
357804004386	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
357804004387	tellurium resistance terB-like protein; Region: terB_like; cd07177
357804004388	metal binding site [ion binding]; metal-binding site
357804004389	Cytochrome c [Energy production and conversion]; Region: COG3258
357804004390	Cytochrome c; Region: Cytochrom_C; pfam00034
357804004391	Cytochrome c; Region: Cytochrom_C; cl11414
357804004392	Cytochrome c; Region: Cytochrom_C; cl11414
357804004393	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
357804004394	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315
357804004395	putative ligand binding site [chemical binding]; other site
357804004396	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804004397	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004398	metal binding site [ion binding]; metal-binding site
357804004399	active site
357804004400	I-site; other site
357804004401	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
357804004402	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804004403	Coenzyme A binding pocket [chemical binding]; other site
357804004404	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
357804004405	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
357804004406	Sulfate transporter family; Region: Sulfate_transp; pfam00916
357804004407	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
357804004408	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
357804004409	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
357804004410	active site
357804004411	ADP/pyrophosphate binding site [chemical binding]; other site
357804004412	dimerization interface [polypeptide binding]; other site
357804004413	allosteric effector site; other site
357804004414	fructose-1,6-bisphosphate binding site; other site
357804004415	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
357804004416	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
357804004417	active site
357804004418	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
357804004419	putative catalytic site [active]
357804004420	putative phosphate binding site [ion binding]; other site
357804004421	active site
357804004422	metal binding site A [ion binding]; metal-binding site
357804004423	DNA binding site [nucleotide binding]
357804004424	putative AP binding site [nucleotide binding]; other site
357804004425	putative metal binding site B [ion binding]; other site
357804004426	Phosphate-starvation-inducible E; Region: PsiE; cl01264
357804004427	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
357804004428	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
357804004429	active site
357804004430	dimerization interface [polypeptide binding]; other site
357804004431	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
357804004432	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
357804004433	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
357804004434	Rrf2 family protein; Region: rrf2_super; TIGR00738
357804004435	cysteine desulfurase; Provisional; Region: PRK14012
357804004436	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
357804004437	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
357804004438	catalytic residue [active]
357804004439	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
357804004440	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
357804004441	trimerization site [polypeptide binding]; other site
357804004442	active site
357804004443	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
357804004444	co-chaperone HscB; Provisional; Region: hscB; PRK05014
357804004445	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
357804004446	HSP70 interaction site [polypeptide binding]; other site
357804004447	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
357804004448	chaperone protein HscA; Provisional; Region: hscA; PRK05183
357804004449	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
357804004450	nucleotide binding site [chemical binding]; other site
357804004451	putative NEF/HSP70 interaction site [polypeptide binding]; other site
357804004452	SBD interface [polypeptide binding]; other site
357804004453	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
357804004454	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
357804004455	catalytic loop [active]
357804004456	iron binding site [ion binding]; other site
357804004457	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
357804004458	aminopeptidase B; Provisional; Region: PRK05015
357804004459	Peptidase; Region: DUF3663; pfam12404
357804004460	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
357804004461	interface (dimer of trimers) [polypeptide binding]; other site
357804004462	Substrate-binding/catalytic site; other site
357804004463	Zn-binding sites [ion binding]; other site
357804004464	fructokinase; Reviewed; Region: PRK09557
357804004465	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
357804004466	nucleotide binding site [chemical binding]; other site
357804004467	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
357804004468	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
357804004469	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
357804004470	nucleophile elbow; other site
357804004471	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
357804004472	Surface antigen; Region: Bac_surface_Ag; pfam01103
357804004473	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
357804004474	dimer interface [polypeptide binding]; other site
357804004475	active site
357804004476	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
357804004477	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
357804004478	putative active site [active]
357804004479	putative dimer interface [polypeptide binding]; other site
357804004480	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
357804004481	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
357804004482	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
357804004483	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
357804004484	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
357804004485	DNA binding residues [nucleotide binding]
357804004486	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
357804004487	metal-binding site [ion binding]
357804004488	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
357804004489	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
357804004490	Soluble P-type ATPase [General function prediction only]; Region: COG4087
357804004491	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
357804004492	active site
357804004493	DNA polymerase IV; Validated; Region: PRK02406
357804004494	DNA binding site [nucleotide binding]
357804004495	DDE superfamily endonuclease; Region: DDE_3; pfam13358
357804004496	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
357804004497	Homeodomain-like domain; Region: HTH_23; pfam13384
357804004498	Winged helix-turn helix; Region: HTH_29; pfam13551
357804004499	Homeodomain-like domain; Region: HTH_32; pfam13565
357804004500	Winged helix-turn helix; Region: HTH_33; pfam13592
357804004501	hypothetical protein; Provisional; Region: PRK09272
357804004502	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
357804004503	Peptidase family M48; Region: Peptidase_M48; cl12018
357804004504	Penicillinase repressor; Region: Pencillinase_R; cl17580
357804004505	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
357804004506	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
357804004507	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
357804004508	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
357804004509	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
357804004510	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
357804004511	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
357804004512	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
357804004513	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
357804004514	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
357804004515	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
357804004516	Homeodomain-like domain; Region: HTH_23; pfam13384
357804004517	Winged helix-turn helix; Region: HTH_29; pfam13551
357804004518	Homeodomain-like domain; Region: HTH_32; pfam13565
357804004519	Winged helix-turn helix; Region: HTH_33; pfam13592
357804004520	DDE superfamily endonuclease; Region: DDE_3; pfam13358
357804004521	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
357804004522	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804004523	S-adenosylmethionine binding site [chemical binding]; other site
357804004524	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
357804004525	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
357804004526	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
357804004527	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
357804004528	hypothetical protein; Provisional; Region: PRK04164
357804004529	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
357804004530	Outer membrane efflux protein; Region: OEP; pfam02321
357804004531	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
357804004532	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804004533	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
357804004534	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
357804004535	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
357804004536	dimerization interface [polypeptide binding]; other site
357804004537	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804004538	dimer interface [polypeptide binding]; other site
357804004539	phosphorylation site [posttranslational modification]
357804004540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804004541	ATP binding site [chemical binding]; other site
357804004542	Mg2+ binding site [ion binding]; other site
357804004543	G-X-G motif; other site
357804004544	osmolarity response regulator; Provisional; Region: ompR; PRK09468
357804004545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804004546	active site
357804004547	phosphorylation site [posttranslational modification]
357804004548	intermolecular recognition site; other site
357804004549	dimerization interface [polypeptide binding]; other site
357804004550	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
357804004551	DNA binding site [nucleotide binding]
357804004552	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
357804004553	dimer interface [polypeptide binding]; other site
357804004554	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
357804004555	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
357804004556	catalytic residues [active]
357804004557	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
357804004558	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
357804004559	catalytic residues [active]
357804004560	Protein of unknown function (DUF3081); Region: DUF3081; pfam11280
357804004561	copper exporting ATPase; Provisional; Region: copA; PRK10671
357804004562	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
357804004563	metal-binding site [ion binding]
357804004564	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
357804004565	metal-binding site [ion binding]
357804004566	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
357804004567	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804004568	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
357804004569	motif II; other site
357804004570	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
357804004571	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
357804004572	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
357804004573	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
357804004574	DNA binding residues [nucleotide binding]
357804004575	dimer interface [polypeptide binding]; other site
357804004576	metal binding site [ion binding]; metal-binding site
357804004577	Cytochrome c; Region: Cytochrom_C; cl11414
357804004578	Cytochrome c; Region: Cytochrom_C; pfam00034
357804004579	CopC domain; Region: CopC; pfam04234
357804004580	Copper resistance protein D; Region: CopD; cl00563
357804004581	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
357804004582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
357804004583	Nucleoside recognition; Region: Gate; pfam07670
357804004584	integron integrase; Region: integrase_gron; TIGR02249
357804004585	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
357804004586	active site
357804004587	DNA binding site [nucleotide binding]
357804004588	Int/Topo IB signature motif; other site
357804004589	Transposase domain (DUF772); Region: DUF772; pfam05598
357804004590	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
357804004591	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
357804004592	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735
357804004593	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736
357804004594	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
357804004595	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
357804004596	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
357804004597	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
357804004598	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
357804004599	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
357804004600	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
357804004601	dimer interface [polypeptide binding]; other site
357804004602	motif 1; other site
357804004603	active site
357804004604	motif 2; other site
357804004605	motif 3; other site
357804004606	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
357804004607	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
357804004608	putative tRNA-binding site [nucleotide binding]; other site
357804004609	B3/4 domain; Region: B3_4; pfam03483
357804004610	tRNA synthetase B5 domain; Region: B5; smart00874
357804004611	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
357804004612	dimer interface [polypeptide binding]; other site
357804004613	motif 1; other site
357804004614	motif 3; other site
357804004615	motif 2; other site
357804004616	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
357804004617	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
357804004618	IHF dimer interface [polypeptide binding]; other site
357804004619	IHF - DNA interface [nucleotide binding]; other site
357804004620	NAD-dependent deacetylase; Provisional; Region: PRK00481
357804004621	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
357804004622	NAD+ binding site [chemical binding]; other site
357804004623	substrate binding site [chemical binding]; other site
357804004624	Zn binding site [ion binding]; other site
357804004625	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
357804004626	Protein of unknown function (DUF2987); Region: DUF2987; pfam11205
357804004627	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
357804004628	Phosphotransferase enzyme family; Region: APH; pfam01636
357804004629	active site
357804004630	substrate binding site [chemical binding]; other site
357804004631	ATP binding site [chemical binding]; other site
357804004632	phosphoglycolate phosphatase; Provisional; Region: PRK13222
357804004633	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804004634	motif II; other site
357804004635	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
357804004636	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
357804004637	Zn2+ binding site [ion binding]; other site
357804004638	Mg2+ binding site [ion binding]; other site
357804004639	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
357804004640	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
357804004641	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
357804004642	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
357804004643	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
357804004644	DNA binding site [nucleotide binding]
357804004645	active site
357804004646	Protein of unknown function (DUF3389); Region: DUF3389; pfam11869
357804004647	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
357804004648	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
357804004649	dimer interface [polypeptide binding]; other site
357804004650	active site
357804004651	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
357804004652	catalytic residues [active]
357804004653	substrate binding site [chemical binding]; other site
357804004654	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804004655	Coenzyme A binding pocket [chemical binding]; other site
357804004656	Predicted amidohydrolase [General function prediction only]; Region: COG0388
357804004657	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
357804004658	putative active site [active]
357804004659	catalytic triad [active]
357804004660	putative dimer interface [polypeptide binding]; other site
357804004661	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
357804004662	FAD binding domain; Region: FAD_binding_4; pfam01565
357804004663	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
357804004664	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
357804004665	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
357804004666	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
357804004667	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
357804004668	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
357804004669	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
357804004670	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
357804004671	Cysteine-rich domain; Region: CCG; pfam02754
357804004672	Cysteine-rich domain; Region: CCG; pfam02754
357804004673	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
357804004674	L-lactate permease; Region: Lactate_perm; cl00701
357804004675	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804004676	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804004677	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
357804004678	putative effector binding pocket; other site
357804004679	dimerization interface [polypeptide binding]; other site
357804004680	NosL; Region: NosL; pfam05573
357804004681	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
357804004682	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
357804004683	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
357804004684	Walker A/P-loop; other site
357804004685	ATP binding site [chemical binding]; other site
357804004686	Q-loop/lid; other site
357804004687	ABC transporter signature motif; other site
357804004688	Walker B; other site
357804004689	D-loop; other site
357804004690	H-loop/switch region; other site
357804004691	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
357804004692	nitrous-oxide reductase; Validated; Region: PRK02888
357804004693	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
357804004694	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
357804004695	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
357804004696	4Fe-4S binding domain; Region: Fer4_5; pfam12801
357804004697	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
357804004698	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
357804004699	hypothetical protein; Provisional; Region: PRK10621
357804004700	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
357804004701	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
357804004702	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
357804004703	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
357804004704	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804004705	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804004706	ABC transporter; Region: ABC_tran_2; pfam12848
357804004707	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804004708	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
357804004709	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
357804004710	dimer interface [polypeptide binding]; other site
357804004711	active site
357804004712	glycine-pyridoxal phosphate binding site [chemical binding]; other site
357804004713	folate binding site [chemical binding]; other site
357804004714	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
357804004715	ATP cone domain; Region: ATP-cone; pfam03477
357804004716	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
357804004717	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
357804004718	catalytic motif [active]
357804004719	Zn binding site [ion binding]; other site
357804004720	RibD C-terminal domain; Region: RibD_C; cl17279
357804004721	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
357804004722	Lumazine binding domain; Region: Lum_binding; pfam00677
357804004723	Lumazine binding domain; Region: Lum_binding; pfam00677
357804004724	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
357804004725	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
357804004726	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
357804004727	dimerization interface [polypeptide binding]; other site
357804004728	active site
357804004729	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
357804004730	homopentamer interface [polypeptide binding]; other site
357804004731	active site
357804004732	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
357804004733	putative RNA binding site [nucleotide binding]; other site
357804004734	Protein of unknown function (DUF445); Region: DUF445; pfam04286
357804004735	EamA-like transporter family; Region: EamA; pfam00892
357804004736	methionine sulfoxide reductase A; Provisional; Region: PRK14054
357804004737	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
357804004738	HAMP domain; Region: HAMP; pfam00672
357804004739	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804004740	metal binding site [ion binding]; metal-binding site
357804004741	active site
357804004742	I-site; other site
357804004743	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804004744	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
357804004745	FAD binding domain; Region: FAD_binding_4; pfam01565
357804004746	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
357804004747	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
357804004748	CoenzymeA binding site [chemical binding]; other site
357804004749	subunit interaction site [polypeptide binding]; other site
357804004750	PHB binding site; other site
357804004751	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
357804004752	S1 domain; Region: S1_2; pfam13509
357804004753	S1 domain; Region: S1_2; pfam13509
357804004754	hypothetical protein; Provisional; Region: PRK11281
357804004755	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
357804004756	Mechanosensitive ion channel; Region: MS_channel; pfam00924
357804004757	putative metal dependent hydrolase; Provisional; Region: PRK11598
357804004758	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
357804004759	Sulfatase; Region: Sulfatase; pfam00884
357804004760	adenosine deaminase; Provisional; Region: PRK09358
357804004761	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
357804004762	active site
357804004763	Protein of unknown function (DUF3012); Region: DUF3012; pfam11216
357804004764	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
357804004765	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
357804004766	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
357804004767	Part of AAA domain; Region: AAA_19; pfam13245
357804004768	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
357804004769	AAA domain; Region: AAA_30; pfam13604
357804004770	Family description; Region: UvrD_C_2; pfam13538
357804004771	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
357804004772	putative deacylase active site [active]
357804004773	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
357804004774	MarC family integral membrane protein; Region: MarC; pfam01914
357804004775	trigger factor; Provisional; Region: tig; PRK01490
357804004776	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
357804004777	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
357804004778	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
357804004779	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
357804004780	oligomer interface [polypeptide binding]; other site
357804004781	active site residues [active]
357804004782	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
357804004783	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
357804004784	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804004785	Walker A motif; other site
357804004786	ATP binding site [chemical binding]; other site
357804004787	Walker B motif; other site
357804004788	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
357804004789	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
357804004790	Found in ATP-dependent protease La (LON); Region: LON; smart00464
357804004791	Found in ATP-dependent protease La (LON); Region: LON; smart00464
357804004792	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804004793	Walker A motif; other site
357804004794	ATP binding site [chemical binding]; other site
357804004795	Walker B motif; other site
357804004796	arginine finger; other site
357804004797	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
357804004798	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
357804004799	IHF dimer interface [polypeptide binding]; other site
357804004800	IHF - DNA interface [nucleotide binding]; other site
357804004801	periplasmic folding chaperone; Provisional; Region: PRK10788
357804004802	SurA N-terminal domain; Region: SurA_N_3; cl07813
357804004803	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
357804004804	elongation factor P; Provisional; Region: PRK04542
357804004805	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
357804004806	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
357804004807	RNA binding site [nucleotide binding]; other site
357804004808	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
357804004809	RNA binding site [nucleotide binding]; other site
357804004810	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
357804004811	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
357804004812	TIGR01666 family membrane protein; Region: YCCS
357804004813	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
357804004814	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
357804004815	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
357804004816	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
357804004817	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
357804004818	homodimer interface [polypeptide binding]; other site
357804004819	NADP binding site [chemical binding]; other site
357804004820	substrate binding site [chemical binding]; other site
357804004821	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
357804004822	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
357804004823	trimer interface [polypeptide binding]; other site
357804004824	eyelet of channel; other site
357804004825	aminotransferase AlaT; Validated; Region: PRK09265
357804004826	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
357804004827	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804004828	homodimer interface [polypeptide binding]; other site
357804004829	catalytic residue [active]
357804004830	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
357804004831	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804004832	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
357804004833	putative dimerization interface [polypeptide binding]; other site
357804004834	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
357804004835	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
357804004836	dimer interface [polypeptide binding]; other site
357804004837	putative functional site; other site
357804004838	putative MPT binding site; other site
357804004839	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
357804004840	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
357804004841	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
357804004842	active site
357804004843	zinc binding site [ion binding]; other site
357804004844	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
357804004845	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
357804004846	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
357804004847	Protein of unknown function, DUF462; Region: DUF462; pfam04315
357804004848	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
357804004849	active site
357804004850	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
357804004851	Helix-turn-helix domain; Region: HTH_38; pfam13936
357804004852	Homeodomain-like domain; Region: HTH_32; pfam13565
357804004853	Integrase core domain; Region: rve; pfam00665
357804004854	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
357804004855	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
357804004856	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
357804004857	Sugar specificity; other site
357804004858	Pyrimidine base specificity; other site
357804004859	ATP-binding site [chemical binding]; other site
357804004860	Protein of unknown function (DUF3581); Region: DUF3581; pfam12119
357804004861	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
357804004862	active site
357804004863	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
357804004864	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
357804004865	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
357804004866	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
357804004867	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
357804004868	Fatty acid desaturase; Region: FA_desaturase; pfam00487
357804004869	Di-iron ligands [ion binding]; other site
357804004870	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
357804004871	Sel1-like repeats; Region: SEL1; smart00671
357804004872	Sel1-like repeats; Region: SEL1; smart00671
357804004873	Sel1-like repeats; Region: SEL1; smart00671
357804004874	Sel1-like repeats; Region: SEL1; smart00671
357804004875	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
357804004876	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804004877	FeS/SAM binding site; other site
357804004878	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
357804004879	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804004880	TPR motif; other site
357804004881	binding surface
357804004882	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804004883	binding surface
357804004884	TPR motif; other site
357804004885	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804004886	binding surface
357804004887	TPR motif; other site
357804004888	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804004889	TPR motif; other site
357804004890	binding surface
357804004891	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
357804004892	binding surface
357804004893	TPR motif; other site
357804004894	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804004895	TPR motif; other site
357804004896	TPR repeat; Region: TPR_11; pfam13414
357804004897	binding surface
357804004898	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
357804004899	metal ion-dependent adhesion site (MIDAS); other site
357804004900	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
357804004901	[2Fe-2S] cluster binding site [ion binding]; other site
357804004902	Domain of unknown function DUF59; Region: DUF59; cl00941
357804004903	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
357804004904	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
357804004905	trimerization site [polypeptide binding]; other site
357804004906	active site
357804004907	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
357804004908	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
357804004909	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
357804004910	catalytic residue [active]
357804004911	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
357804004912	FeS assembly protein SufD; Region: sufD; TIGR01981
357804004913	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
357804004914	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
357804004915	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
357804004916	Walker A/P-loop; other site
357804004917	ATP binding site [chemical binding]; other site
357804004918	Q-loop/lid; other site
357804004919	ABC transporter signature motif; other site
357804004920	Walker B; other site
357804004921	D-loop; other site
357804004922	H-loop/switch region; other site
357804004923	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
357804004924	putative ABC transporter; Region: ycf24; CHL00085
357804004925	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
357804004926	metal ion-dependent adhesion site (MIDAS); other site
357804004927	DDE superfamily endonuclease; Region: DDE_3; pfam13358
357804004928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
357804004929	Homeodomain-like domain; Region: HTH_23; pfam13384
357804004930	Winged helix-turn helix; Region: HTH_29; pfam13551
357804004931	Homeodomain-like domain; Region: HTH_32; pfam13565
357804004932	Winged helix-turn helix; Region: HTH_33; pfam13592
357804004933	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
357804004934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804004935	Walker A/P-loop; other site
357804004936	ATP binding site [chemical binding]; other site
357804004937	Q-loop/lid; other site
357804004938	ABC transporter signature motif; other site
357804004939	Walker B; other site
357804004940	D-loop; other site
357804004941	H-loop/switch region; other site
357804004942	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
357804004943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804004944	dimer interface [polypeptide binding]; other site
357804004945	conserved gate region; other site
357804004946	putative PBP binding loops; other site
357804004947	ABC-ATPase subunit interface; other site
357804004948	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
357804004949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804004950	dimer interface [polypeptide binding]; other site
357804004951	conserved gate region; other site
357804004952	putative PBP binding loops; other site
357804004953	ABC-ATPase subunit interface; other site
357804004954	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
357804004955	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804004956	substrate binding pocket [chemical binding]; other site
357804004957	membrane-bound complex binding site; other site
357804004958	hinge residues; other site
357804004959	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
357804004960	putative catalytic site [active]
357804004961	putative metal binding site [ion binding]; other site
357804004962	putative phosphate binding site [ion binding]; other site
357804004963	Phospholipid methyltransferase; Region: PEMT; cl17370
357804004964	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
357804004965	Interdomain contacts; other site
357804004966	Cytokine receptor motif; other site
357804004967	Major Facilitator Superfamily; Region: MFS_1; pfam07690
357804004968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804004969	putative substrate translocation pore; other site
357804004970	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
357804004971	hypothetical protein; Provisional; Region: PRK05208
357804004972	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
357804004973	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
357804004974	active site clefts [active]
357804004975	zinc binding site [ion binding]; other site
357804004976	dimer interface [polypeptide binding]; other site
357804004977	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
357804004978	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
357804004979	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
357804004980	active site
357804004981	helicase 45; Provisional; Region: PTZ00424
357804004982	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
357804004983	ATP binding site [chemical binding]; other site
357804004984	Mg++ binding site [ion binding]; other site
357804004985	motif III; other site
357804004986	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804004987	nucleotide binding region [chemical binding]; other site
357804004988	ATP-binding site [chemical binding]; other site
357804004989	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
357804004990	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
357804004991	putative dimer interface [polypeptide binding]; other site
357804004992	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
357804004993	nucleoside/Zn binding site; other site
357804004994	dimer interface [polypeptide binding]; other site
357804004995	catalytic motif [active]
357804004996	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
357804004997	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
357804004998	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
357804004999	Proline dehydrogenase; Region: Pro_dh; pfam01619
357804005000	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
357804005001	Glutamate binding site [chemical binding]; other site
357804005002	NAD binding site [chemical binding]; other site
357804005003	catalytic residues [active]
357804005004	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
357804005005	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
357804005006	NAD(P) binding site [chemical binding]; other site
357804005007	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
357804005008	Peptidase family M23; Region: Peptidase_M23; pfam01551
357804005009	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
357804005010	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
357804005011	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
357804005012	DNA photolyase; Region: DNA_photolyase; pfam00875
357804005013	DNA photolyase; Region: DNA_photolyase; pfam00875
357804005014	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
357804005015	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
357804005016	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
357804005017	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
357804005018	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
357804005019	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
357804005020	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
357804005021	MarC family integral membrane protein; Region: MarC; pfam01914
357804005022	PEP-CTERM motif; Region: VPEP; pfam07589
357804005023	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
357804005024	Coiled-coil receptor-binding R-domain of colicin E2; Region: E2R135; pfam11570
357804005025	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804005026	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804005027	metal binding site [ion binding]; metal-binding site
357804005028	active site
357804005029	I-site; other site
357804005030	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804005031	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
357804005032	Predicted amidohydrolase [General function prediction only]; Region: COG0388
357804005033	active site
357804005034	catalytic triad [active]
357804005035	dimer interface [polypeptide binding]; other site
357804005036	Uncharacterized conserved protein [Function unknown]; Region: COG0397
357804005037	hypothetical protein; Validated; Region: PRK00029
357804005038	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
357804005039	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
357804005040	2-methylcitrate dehydratase; Region: prpD; TIGR02330
357804005041	Uncharacterized conserved protein [Function unknown]; Region: COG3791
357804005042	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
357804005043	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804005044	putative substrate translocation pore; other site
357804005045	Predicted ATPase [General function prediction only]; Region: COG1485
357804005046	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804005047	Walker A/P-loop; other site
357804005048	ATP binding site [chemical binding]; other site
357804005049	ABC transporter signature motif; other site
357804005050	Walker B; other site
357804005051	D-loop; other site
357804005052	H-loop/switch region; other site
357804005053	Transposase; Region: DEDD_Tnp_IS110; pfam01548
357804005054	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
357804005055	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
357804005056	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
357804005057	Walker A/P-loop; other site
357804005058	ATP binding site [chemical binding]; other site
357804005059	Q-loop/lid; other site
357804005060	ABC transporter signature motif; other site
357804005061	Walker B; other site
357804005062	D-loop; other site
357804005063	H-loop/switch region; other site
357804005064	FtsX-like permease family; Region: FtsX; pfam02687
357804005065	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
357804005066	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
357804005067	helicase Cas3; Provisional; Region: PRK09694
357804005068	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
357804005069	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
357804005070	hypothetical protein; Provisional; Region: PRK14561
357804005071	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
357804005072	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719
357804005073	CT1975-like protein; Region: Cas_CT1975; pfam09344
357804005074	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
357804005075	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
357804005076	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
357804005077	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
357804005078	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
357804005079	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
357804005080	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
357804005081	catalytic residues [active]
357804005082	catalytic nucleophile [active]
357804005083	Presynaptic Site I dimer interface [polypeptide binding]; other site
357804005084	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
357804005085	Synaptic Flat tetramer interface [polypeptide binding]; other site
357804005086	Synaptic Site I dimer interface [polypeptide binding]; other site
357804005087	DNA binding site [nucleotide binding]
357804005088	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
357804005089	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
357804005090	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
357804005091	integrase; Provisional; Region: PRK09692
357804005092	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
357804005093	active site
357804005094	Int/Topo IB signature motif; other site
357804005095	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
357804005096	SmpB-tmRNA interface; other site
357804005097	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
357804005098	putative coenzyme Q binding site [chemical binding]; other site
357804005099	hypothetical protein; Validated; Region: PRK01777
357804005100	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
357804005101	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
357804005102	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
357804005103	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
357804005104	tRNA; other site
357804005105	putative tRNA binding site [nucleotide binding]; other site
357804005106	putative NADP binding site [chemical binding]; other site
357804005107	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
357804005108	peptide chain release factor 1; Validated; Region: prfA; PRK00591
357804005109	This domain is found in peptide chain release factors; Region: PCRF; smart00937
357804005110	RF-1 domain; Region: RF-1; pfam00472
357804005111	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
357804005112	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804005113	S-adenosylmethionine binding site [chemical binding]; other site
357804005114	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
357804005115	Uncharacterized conserved protein [Function unknown]; Region: COG2912
357804005116	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
357804005117	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804005118	binding surface
357804005119	TPR motif; other site
357804005120	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
357804005121	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
357804005122	Protein of unknown function (DUF423); Region: DUF423; pfam04241
357804005123	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
357804005124	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
357804005125	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
357804005126	Peptidase M15; Region: Peptidase_M15_3; cl01194
357804005127	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
357804005128	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
357804005129	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
357804005130	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
357804005131	PspC domain; Region: PspC; cl00864
357804005132	phage shock protein C; Region: phageshock_pspC; TIGR02978
357804005133	phage shock protein B; Provisional; Region: pspB; PRK09458
357804005134	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
357804005135	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
357804005136	HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3
357804005137	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804005138	active site
357804005139	motif I; other site
357804005140	motif II; other site
357804005141	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804005142	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
357804005143	Beta-lactamase; Region: Beta-lactamase; pfam00144
357804005144	Protein of unknown function (DUF502); Region: DUF502; pfam04367
357804005145	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
357804005146	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
357804005147	active site
357804005148	HIGH motif; other site
357804005149	KMSKS motif; other site
357804005150	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
357804005151	tRNA binding surface [nucleotide binding]; other site
357804005152	anticodon binding site; other site
357804005153	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
357804005154	dimer interface [polypeptide binding]; other site
357804005155	putative tRNA-binding site [nucleotide binding]; other site
357804005156	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
357804005157	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
357804005158	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
357804005159	active site
357804005160	HIGH motif; other site
357804005161	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
357804005162	active site
357804005163	KMSKS motif; other site
357804005164	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
357804005165	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
357804005166	active site
357804005167	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
357804005168	DDE superfamily endonuclease; Region: DDE_5; cl17874
357804005169	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
357804005170	Acid Phosphatase; Region: Acid_PPase; cl17256
357804005171	Methyltransferase domain; Region: Methyltransf_23; pfam13489
357804005172	Methyltransferase domain; Region: Methyltransf_12; pfam08242
357804005173	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
357804005174	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
357804005175	dimer interface [polypeptide binding]; other site
357804005176	substrate binding site [chemical binding]; other site
357804005177	metal binding site [ion binding]; metal-binding site
357804005178	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
357804005179	putative transposase OrfB; Reviewed; Region: PHA02517
357804005180	HTH-like domain; Region: HTH_21; pfam13276
357804005181	Integrase core domain; Region: rve; pfam00665
357804005182	Integrase core domain; Region: rve_3; pfam13683
357804005183	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
357804005184	Transposase; Region: HTH_Tnp_1; cl17663
357804005185	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
357804005186	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
357804005187	dimer interface [polypeptide binding]; other site
357804005188	active site residues [active]
357804005189	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
357804005190	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
357804005191	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
357804005192	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
357804005193	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
357804005194	dimer interface [polypeptide binding]; other site
357804005195	active site
357804005196	metal binding site [ion binding]; metal-binding site
357804005197	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
357804005198	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
357804005199	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
357804005200	metal binding site [ion binding]; metal-binding site
357804005201	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
357804005202	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
357804005203	substrate binding site [chemical binding]; other site
357804005204	glutamase interaction surface [polypeptide binding]; other site
357804005205	Predicted metal-binding protein [General function prediction only]; Region: COG3019
357804005206	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
357804005207	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
357804005208	catalytic residues [active]
357804005209	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
357804005210	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
357804005211	putative active site [active]
357804005212	oxyanion strand; other site
357804005213	catalytic triad [active]
357804005214	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
357804005215	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804005216	active site
357804005217	motif I; other site
357804005218	motif II; other site
357804005219	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
357804005220	putative active site pocket [active]
357804005221	4-fold oligomerization interface [polypeptide binding]; other site
357804005222	metal binding residues [ion binding]; metal-binding site
357804005223	3-fold/trimer interface [polypeptide binding]; other site
357804005224	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
357804005225	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
357804005226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804005227	homodimer interface [polypeptide binding]; other site
357804005228	catalytic residue [active]
357804005229	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
357804005230	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
357804005231	NAD binding site [chemical binding]; other site
357804005232	dimerization interface [polypeptide binding]; other site
357804005233	product binding site; other site
357804005234	substrate binding site [chemical binding]; other site
357804005235	zinc binding site [ion binding]; other site
357804005236	catalytic residues [active]
357804005237	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
357804005238	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
357804005239	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
357804005240	Protein of unknown function (DUF2986); Region: DUF2986; pfam11661
357804005241	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
357804005242	disulfide bond formation protein B; Provisional; Region: PRK01749
357804005243	fatty acid metabolism regulator; Provisional; Region: PRK04984
357804005244	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804005245	DNA-binding site [nucleotide binding]; DNA binding site
357804005246	FadR C-terminal domain; Region: FadR_C; pfam07840
357804005247	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
357804005248	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804005249	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
357804005250	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
357804005251	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
357804005252	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
357804005253	recombination factor protein RarA; Reviewed; Region: PRK13342
357804005254	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804005255	Walker A motif; other site
357804005256	ATP binding site [chemical binding]; other site
357804005257	Walker B motif; other site
357804005258	arginine finger; other site
357804005259	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
357804005260	CrcB-like protein; Region: CRCB; cl09114
357804005261	seryl-tRNA synthetase; Provisional; Region: PRK05431
357804005262	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
357804005263	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
357804005264	dimer interface [polypeptide binding]; other site
357804005265	active site
357804005266	motif 1; other site
357804005267	motif 2; other site
357804005268	motif 3; other site
357804005269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804005270	muropeptide transporter; Reviewed; Region: ampG; PRK11902
357804005271	putative substrate translocation pore; other site
357804005272	ribonuclease D; Provisional; Region: PRK10829
357804005273	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
357804005274	catalytic site [active]
357804005275	putative active site [active]
357804005276	putative substrate binding site [chemical binding]; other site
357804005277	HRDC domain; Region: HRDC; pfam00570
357804005278	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
357804005279	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
357804005280	substrate binding site [chemical binding]; other site
357804005281	ligand binding site [chemical binding]; other site
357804005282	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
357804005283	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
357804005284	substrate binding site [chemical binding]; other site
357804005285	Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248
357804005286	active site
357804005287	S2 subsite; other site
357804005288	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
357804005289	ferredoxin-NADP reductase; Provisional; Region: PRK10926
357804005290	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
357804005291	FAD binding pocket [chemical binding]; other site
357804005292	FAD binding motif [chemical binding]; other site
357804005293	phosphate binding motif [ion binding]; other site
357804005294	beta-alpha-beta structure motif; other site
357804005295	NAD binding pocket [chemical binding]; other site
357804005296	Protein of unknown function (DUF330); Region: DUF330; cl01135
357804005297	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
357804005298	mce related protein; Region: MCE; pfam02470
357804005299	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
357804005300	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
357804005301	Walker A/P-loop; other site
357804005302	ATP binding site [chemical binding]; other site
357804005303	Q-loop/lid; other site
357804005304	ABC transporter signature motif; other site
357804005305	Walker B; other site
357804005306	D-loop; other site
357804005307	H-loop/switch region; other site
357804005308	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
357804005309	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
357804005310	Permease; Region: Permease; pfam02405
357804005311	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
357804005312	Homeodomain-like domain; Region: HTH_23; pfam13384
357804005313	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
357804005314	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
357804005315	active site
357804005316	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
357804005317	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
357804005318	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
357804005319	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
357804005320	putative NADP binding site [chemical binding]; other site
357804005321	active site
357804005322	Beta-ketoacyl synthase, C-terminal domain; Region: Ketoacyl-synt_C; pfam02801
357804005323	Acyl transferase domain; Region: Acyl_transf_1; cl08282
357804005324	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
357804005325	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
357804005326	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
357804005327	active site
357804005328	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
357804005329	active site
357804005330	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
357804005331	active site 2 [active]
357804005332	dimer interface [polypeptide binding]; other site
357804005333	active site 1 [active]
357804005334	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
357804005335	active site 1 [active]
357804005336	dimer interface [polypeptide binding]; other site
357804005337	active site 2 [active]
357804005338	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
357804005339	FMN binding site [chemical binding]; other site
357804005340	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
357804005341	substrate binding site [chemical binding]; other site
357804005342	putative catalytic residue [active]
357804005343	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804005344	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804005345	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
357804005346	putative effector binding pocket; other site
357804005347	dimerization interface [polypeptide binding]; other site
357804005348	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
357804005349	Cysteine-rich domain; Region: CCG; pfam02754
357804005350	Cysteine-rich domain; Region: CCG; pfam02754
357804005351	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
357804005352	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
357804005353	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
357804005354	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
357804005355	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
357804005356	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
357804005357	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
357804005358	GAF domain; Region: GAF; pfam01590
357804005359	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804005360	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804005361	metal binding site [ion binding]; metal-binding site
357804005362	active site
357804005363	I-site; other site
357804005364	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
357804005365	fructokinase; Reviewed; Region: PRK09557
357804005366	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
357804005367	nucleotide binding site [chemical binding]; other site
357804005368	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
357804005369	active site
357804005370	catalytic triad [active]
357804005371	oxyanion hole [active]
357804005372	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
357804005373	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
357804005374	putative metal binding site [ion binding]; other site
357804005375	hypothetical protein; Provisional; Region: PRK10621
357804005376	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
357804005377	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
357804005378	Methyltransferase domain; Region: Methyltransf_23; pfam13489
357804005379	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804005380	S-adenosylmethionine binding site [chemical binding]; other site
357804005381	Cupin domain; Region: Cupin_2; cl17218
357804005382	protein structure with unknown function; Region: DUF4144; pfam13642
357804005383	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
357804005384	active site
357804005385	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
357804005386	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
357804005387	Uncharacterized conserved protein [Function unknown]; Region: COG1359
357804005388	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804005389	NmrA-like family; Region: NmrA; pfam05368
357804005390	NAD(P) binding site [chemical binding]; other site
357804005391	active site
357804005392	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
357804005393	LGFP repeat; Region: LGFP; pfam08310
357804005394	LGFP repeat; Region: LGFP; pfam08310
357804005395	LGFP repeat; Region: LGFP; pfam08310
357804005396	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
357804005397	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
357804005398	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
357804005399	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
357804005400	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
357804005401	EamA-like transporter family; Region: EamA; pfam00892
357804005402	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804005403	PAS domain; Region: PAS_9; pfam13426
357804005404	putative active site [active]
357804005405	heme pocket [chemical binding]; other site
357804005406	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804005407	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804005408	metal binding site [ion binding]; metal-binding site
357804005409	active site
357804005410	I-site; other site
357804005411	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804005412	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
357804005413	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
357804005414	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
357804005415	Isochorismatase family; Region: Isochorismatase; pfam00857
357804005416	catalytic triad [active]
357804005417	metal binding site [ion binding]; metal-binding site
357804005418	conserved cis-peptide bond; other site
357804005419	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
357804005420	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
357804005421	active site
357804005422	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
357804005423	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
357804005424	active site
357804005425	substrate binding site [chemical binding]; other site
357804005426	trimer interface [polypeptide binding]; other site
357804005427	CoA binding site [chemical binding]; other site
357804005428	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
357804005429	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
357804005430	oligomer interface [polypeptide binding]; other site
357804005431	metal binding site [ion binding]; metal-binding site
357804005432	metal binding site [ion binding]; metal-binding site
357804005433	Cl binding site [ion binding]; other site
357804005434	aspartate ring; other site
357804005435	basic sphincter; other site
357804005436	putative hydrophobic gate; other site
357804005437	periplasmic entrance; other site
357804005438	K-Cl cotransporter; Region: 2a30; TIGR00930
357804005439	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
357804005440	Na binding site [ion binding]; other site
357804005441	Mechanosensitive ion channel; Region: MS_channel; pfam00924
357804005442	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
357804005443	Protein of unknown function, DUF399; Region: DUF399; pfam04187
357804005444	Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955
357804005445	fumarate hydratase; Reviewed; Region: fumC; PRK00485
357804005446	Class II fumarases; Region: Fumarase_classII; cd01362
357804005447	active site
357804005448	tetramer interface [polypeptide binding]; other site
357804005449	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
357804005450	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256
357804005451	putative active site [active]
357804005452	Zn binding site [ion binding]; other site
357804005453	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
357804005454	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
357804005455	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
357804005456	putative N-terminal domain interface [polypeptide binding]; other site
357804005457	putative dimer interface [polypeptide binding]; other site
357804005458	putative substrate binding pocket (H-site) [chemical binding]; other site
357804005459	Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894
357804005460	malate dehydrogenase; Provisional; Region: PRK13529
357804005461	Malic enzyme, N-terminal domain; Region: malic; pfam00390
357804005462	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
357804005463	NAD(P) binding site [chemical binding]; other site
357804005464	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
357804005465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804005466	active site
357804005467	phosphorylation site [posttranslational modification]
357804005468	intermolecular recognition site; other site
357804005469	dimerization interface [polypeptide binding]; other site
357804005470	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804005471	Walker A motif; other site
357804005472	ATP binding site [chemical binding]; other site
357804005473	Walker B motif; other site
357804005474	arginine finger; other site
357804005475	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
357804005476	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804005477	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
357804005478	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804005479	putative active site [active]
357804005480	heme pocket [chemical binding]; other site
357804005481	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804005482	dimer interface [polypeptide binding]; other site
357804005483	phosphorylation site [posttranslational modification]
357804005484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804005485	ATP binding site [chemical binding]; other site
357804005486	Mg2+ binding site [ion binding]; other site
357804005487	G-X-G motif; other site
357804005488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804005489	Response regulator receiver domain; Region: Response_reg; pfam00072
357804005490	active site
357804005491	phosphorylation site [posttranslational modification]
357804005492	intermolecular recognition site; other site
357804005493	dimerization interface [polypeptide binding]; other site
357804005494	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
357804005495	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
357804005496	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804005497	Walker A motif; other site
357804005498	ATP binding site [chemical binding]; other site
357804005499	Walker B motif; other site
357804005500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
357804005501	threonine synthase; Validated; Region: PRK06260
357804005502	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
357804005503	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
357804005504	catalytic residues [active]
357804005505	Protein of unknown function (DUF465); Region: DUF465; pfam04325
357804005506	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
357804005507	Protein export membrane protein; Region: SecD_SecF; cl14618
357804005508	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
357804005509	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804005510	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
357804005511	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
357804005512	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
357804005513	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
357804005514	YrhK-like protein; Region: YrhK; pfam14145
357804005515	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
357804005516	30S subunit binding site; other site
357804005517	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
357804005518	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
357804005519	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
357804005520	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
357804005521	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804005522	Walker A/P-loop; other site
357804005523	ATP binding site [chemical binding]; other site
357804005524	Q-loop/lid; other site
357804005525	ABC transporter signature motif; other site
357804005526	Walker B; other site
357804005527	D-loop; other site
357804005528	H-loop/switch region; other site
357804005529	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
357804005530	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
357804005531	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
357804005532	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
357804005533	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
357804005534	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804005535	NAD(P) binding site [chemical binding]; other site
357804005536	active site
357804005537	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
357804005538	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
357804005539	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
357804005540	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
357804005541	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
357804005542	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
357804005543	active site
357804005544	metal binding site [ion binding]; metal-binding site
357804005545	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804005546	PAS domain; Region: PAS_9; pfam13426
357804005547	putative active site [active]
357804005548	heme pocket [chemical binding]; other site
357804005549	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
357804005550	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
357804005551	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
357804005552	SOUL heme-binding protein; Region: SOUL; pfam04832
357804005553	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
357804005554	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
357804005555	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
357804005556	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
357804005557	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
357804005558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
357804005559	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
357804005560	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
357804005561	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
357804005562	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
357804005563	putative C-terminal domain interface [polypeptide binding]; other site
357804005564	putative GSH binding site (G-site) [chemical binding]; other site
357804005565	putative dimer interface [polypeptide binding]; other site
357804005566	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
357804005567	putative N-terminal domain interface [polypeptide binding]; other site
357804005568	putative dimer interface [polypeptide binding]; other site
357804005569	putative substrate binding pocket (H-site) [chemical binding]; other site
357804005570	Transcriptional activator [Transcription]; Region: ChrR; COG3806
357804005571	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
357804005572	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
357804005573	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
357804005574	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
357804005575	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
357804005576	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
357804005577	putative substrate translocation pore; other site
357804005578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
357804005579	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
357804005580	Peptidase family M48; Region: Peptidase_M48; pfam01435
357804005581	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
357804005582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804005583	putative substrate translocation pore; other site
357804005584	putative MFS family transporter protein; Provisional; Region: PRK03633
357804005585	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
357804005586	EamA-like transporter family; Region: EamA; pfam00892
357804005587	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
357804005588	EamA-like transporter family; Region: EamA; pfam00892
357804005589	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
357804005590	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
357804005591	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
357804005592	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
357804005593	putative dimer interface [polypeptide binding]; other site
357804005594	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
357804005595	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
357804005596	ATP binding site [chemical binding]; other site
357804005597	Mg++ binding site [ion binding]; other site
357804005598	motif III; other site
357804005599	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804005600	nucleotide binding region [chemical binding]; other site
357804005601	ATP-binding site [chemical binding]; other site
357804005602	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
357804005603	nucleoside/Zn binding site; other site
357804005604	dimer interface [polypeptide binding]; other site
357804005605	catalytic motif [active]
357804005606	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
357804005607	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
357804005608	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
357804005609	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
357804005610	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
357804005611	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
357804005612	RNA binding site [nucleotide binding]; other site
357804005613	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
357804005614	Family of unknown function (DUF633); Region: DUF633; pfam04816
357804005615	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686
357804005616	nudix motif; other site
357804005617	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
357804005618	Ion channel; Region: Ion_trans_2; pfam07885
357804005619	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
357804005620	Helix-turn-helix domain; Region: HTH_38; pfam13936
357804005621	Homeodomain-like domain; Region: HTH_32; pfam13565
357804005622	Integrase core domain; Region: rve; pfam00665
357804005623	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
357804005624	putative active site [active]
357804005625	putative metal binding site [ion binding]; other site
357804005626	YEATS family; Region: YEATS; pfam03366
357804005627	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
357804005628	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
357804005629	PAS domain; Region: PAS_9; pfam13426
357804005630	putative active site [active]
357804005631	heme pocket [chemical binding]; other site
357804005632	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804005633	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804005634	metal binding site [ion binding]; metal-binding site
357804005635	active site
357804005636	I-site; other site
357804005637	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
357804005638	sulfotransferase; Region: PLN02164
357804005639	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
357804005640	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
357804005641	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
357804005642	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
357804005643	DHHA2 domain; Region: DHHA2; pfam02833
357804005644	Predicted permeases [General function prediction only]; Region: COG0701
357804005645	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
357804005646	Cytochrome c; Region: Cytochrom_C; pfam00034
357804005647	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
357804005648	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
357804005649	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
357804005650	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
357804005651	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
357804005652	catalytic loop [active]
357804005653	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
357804005654	iron binding site [ion binding]; other site
357804005655	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
357804005656	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
357804005657	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
357804005658	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
357804005659	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
357804005660	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
357804005661	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
357804005662	Ligand binding site; other site
357804005663	metal-binding site
357804005664	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
357804005665	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
357804005666	putative protein phosphatase; Region: PHA02239
357804005667	XdhC Rossmann domain; Region: XdhC_C; pfam13478
357804005668	CHASE domain; Region: CHASE; pfam03924
357804005669	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804005670	PAS fold; Region: PAS_3; pfam08447
357804005671	putative active site [active]
357804005672	heme pocket [chemical binding]; other site
357804005673	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804005674	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804005675	metal binding site [ion binding]; metal-binding site
357804005676	active site
357804005677	I-site; other site
357804005678	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
357804005679	PAS domain S-box; Region: sensory_box; TIGR00229
357804005680	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
357804005681	putative active site [active]
357804005682	heme pocket [chemical binding]; other site
357804005683	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804005684	PAS domain; Region: PAS_9; pfam13426
357804005685	putative active site [active]
357804005686	heme pocket [chemical binding]; other site
357804005687	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804005688	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804005689	metal binding site [ion binding]; metal-binding site
357804005690	active site
357804005691	I-site; other site
357804005692	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804005693	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
357804005694	CheB methylesterase; Region: CheB_methylest; pfam01339
357804005695	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
357804005696	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
357804005697	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
357804005698	PAS domain; Region: PAS_10; pfam13596
357804005699	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804005700	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804005701	metal binding site [ion binding]; metal-binding site
357804005702	active site
357804005703	I-site; other site
357804005704	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804005705	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
357804005706	arsenical-resistance protein; Region: acr3; TIGR00832
357804005707	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
357804005708	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
357804005709	active site
357804005710	nucleophile elbow; other site
357804005711	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
357804005712	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
357804005713	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
357804005714	Protein of unknown function (DUF3087); Region: DUF3087; pfam11286
357804005715	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
357804005716	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
357804005717	substrate-cofactor binding pocket; other site
357804005718	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804005719	catalytic residue [active]
357804005720	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
357804005721	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
357804005722	NAD(P) binding site [chemical binding]; other site
357804005723	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
357804005724	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
357804005725	DNA polymerase II; Reviewed; Region: PRK05762
357804005726	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
357804005727	active site
357804005728	catalytic site [active]
357804005729	substrate binding site [chemical binding]; other site
357804005730	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
357804005731	active site
357804005732	metal-binding site
357804005733	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
357804005734	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
357804005735	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
357804005736	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804005737	binding surface
357804005738	TPR motif; other site
357804005739	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
357804005740	dihydrodipicolinate synthase; Region: dapA; TIGR00674
357804005741	dimer interface [polypeptide binding]; other site
357804005742	active site
357804005743	catalytic residue [active]
357804005744	lipoprotein; Provisional; Region: PRK11679
357804005745	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
357804005746	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
357804005747	ATP binding site [chemical binding]; other site
357804005748	active site
357804005749	substrate binding site [chemical binding]; other site
357804005750	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
357804005751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804005752	active site
357804005753	phosphorylation site [posttranslational modification]
357804005754	intermolecular recognition site; other site
357804005755	dimerization interface [polypeptide binding]; other site
357804005756	Transcriptional regulator; Region: CitT; pfam12431
357804005757	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
357804005758	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
357804005759	acyl-activating enzyme (AAE) consensus motif; other site
357804005760	putative AMP binding site [chemical binding]; other site
357804005761	putative active site [active]
357804005762	putative CoA binding site [chemical binding]; other site
357804005763	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
357804005764	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
357804005765	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
357804005766	substrate binding site [chemical binding]; other site
357804005767	ligand binding site [chemical binding]; other site
357804005768	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
357804005769	substrate binding site [chemical binding]; other site
357804005770	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
357804005771	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
357804005772	dimer interface [polypeptide binding]; other site
357804005773	active site
357804005774	citrylCoA binding site [chemical binding]; other site
357804005775	oxalacetate/citrate binding site [chemical binding]; other site
357804005776	coenzyme A binding site [chemical binding]; other site
357804005777	catalytic triad [active]
357804005778	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
357804005779	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
357804005780	tetramer interface [polypeptide binding]; other site
357804005781	active site
357804005782	Mg2+/Mn2+ binding site [ion binding]; other site
357804005783	Transcriptional regulators [Transcription]; Region: GntR; COG1802
357804005784	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804005785	DNA-binding site [nucleotide binding]; DNA binding site
357804005786	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
357804005787	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
357804005788	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
357804005789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
357804005790	sugar phosphate phosphatase; Provisional; Region: PRK10513
357804005791	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804005792	active site
357804005793	motif I; other site
357804005794	motif II; other site
357804005795	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804005796	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
357804005797	DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502
357804005798	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
357804005799	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
357804005800	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
357804005801	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
357804005802	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
357804005803	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804005804	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804005805	metal binding site [ion binding]; metal-binding site
357804005806	active site
357804005807	I-site; other site
357804005808	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804005809	DNA-binding site [nucleotide binding]; DNA binding site
357804005810	RNA-binding motif; other site
357804005811	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
357804005812	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
357804005813	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
357804005814	active site
357804005815	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
357804005816	LssY C-terminus; Region: LssY_C; pfam14067
357804005817	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_22; cd04681
357804005818	nudix motif; other site
357804005819	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
357804005820	active site
357804005821	catalytic site [active]
357804005822	substrate binding site [chemical binding]; other site
357804005823	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
357804005824	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804005825	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804005826	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
357804005827	dimerization interface [polypeptide binding]; other site
357804005828	succinic semialdehyde dehydrogenase; Region: PLN02278
357804005829	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
357804005830	tetramerization interface [polypeptide binding]; other site
357804005831	NAD(P) binding site [chemical binding]; other site
357804005832	catalytic residues [active]
357804005833	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
357804005834	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
357804005835	inhibitor-cofactor binding pocket; inhibition site
357804005836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804005837	catalytic residue [active]
357804005838	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
357804005839	Mechanosensitive ion channel; Region: MS_channel; pfam00924
357804005840	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
357804005841	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
357804005842	phosphate binding site [ion binding]; other site
357804005843	putative substrate binding pocket [chemical binding]; other site
357804005844	dimer interface [polypeptide binding]; other site
357804005845	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
357804005846	active site flap/lid [active]
357804005847	nucleophilic elbow; other site
357804005848	catalytic triad [active]
357804005849	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
357804005850	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
357804005851	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804005852	ATP binding site [chemical binding]; other site
357804005853	putative Mg++ binding site [ion binding]; other site
357804005854	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
357804005855	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
357804005856	Part of AAA domain; Region: AAA_19; pfam13245
357804005857	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
357804005858	AAA domain; Region: AAA_12; pfam13087
357804005859	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
357804005860	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
357804005861	active site
357804005862	DNA binding site [nucleotide binding]
357804005863	Int/Topo IB signature motif; other site
357804005864	Cache domain; Region: Cache_1; pfam02743
357804005865	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
357804005866	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
357804005867	active site
357804005868	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
357804005869	conserved cys residue [active]
357804005870	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
357804005871	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
357804005872	active site
357804005873	metal binding site [ion binding]; metal-binding site
357804005874	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
357804005875	putative active site [active]
357804005876	putative metal binding residues [ion binding]; other site
357804005877	signature motif; other site
357804005878	putative dimer interface [polypeptide binding]; other site
357804005879	putative phosphate binding site [ion binding]; other site
357804005880	hypothetical protein; Provisional; Region: PRK11239
357804005881	Protein of unknown function, DUF480; Region: DUF480; pfam04337
357804005882	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
357804005883	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
357804005884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804005885	Coenzyme A binding pocket [chemical binding]; other site
357804005886	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
357804005887	Sucrose-6-phosphate phosphohydrolase C-terminal; Region: S6PP_C; pfam08472
357804005888	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
357804005889	active site
357804005890	metal binding site [ion binding]; metal-binding site
357804005891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
357804005892	Family of unknown function (DUF490); Region: DUF490; pfam04357
357804005893	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
357804005894	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
357804005895	Surface antigen; Region: Bac_surface_Ag; pfam01103
357804005896	heat shock protein HtpX; Provisional; Region: PRK05457
357804005897	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
357804005898	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
357804005899	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
357804005900	Walker A/P-loop; other site
357804005901	ATP binding site [chemical binding]; other site
357804005902	Q-loop/lid; other site
357804005903	ABC transporter signature motif; other site
357804005904	Walker B; other site
357804005905	D-loop; other site
357804005906	H-loop/switch region; other site
357804005907	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
357804005908	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804005909	dimer interface [polypeptide binding]; other site
357804005910	conserved gate region; other site
357804005911	putative PBP binding loops; other site
357804005912	ABC-ATPase subunit interface; other site
357804005913	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
357804005914	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804005915	substrate binding pocket [chemical binding]; other site
357804005916	membrane-bound complex binding site; other site
357804005917	hinge residues; other site
357804005918	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
357804005919	AAA domain; Region: AAA_26; pfam13500
357804005920	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
357804005921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804005922	S-adenosylmethionine binding site [chemical binding]; other site
357804005923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
357804005924	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
357804005925	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
357804005926	substrate-cofactor binding pocket; other site
357804005927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804005928	catalytic residue [active]
357804005929	biotin synthase; Provisional; Region: PRK15108
357804005930	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804005931	FeS/SAM binding site; other site
357804005932	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
357804005933	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
357804005934	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
357804005935	inhibitor-cofactor binding pocket; inhibition site
357804005936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804005937	catalytic residue [active]
357804005938	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
357804005939	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
357804005940	putative dimer interface [polypeptide binding]; other site
357804005941	putative anticodon binding site; other site
357804005942	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
357804005943	homodimer interface [polypeptide binding]; other site
357804005944	motif 1; other site
357804005945	motif 2; other site
357804005946	active site
357804005947	motif 3; other site
357804005948	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
357804005949	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804005950	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
357804005951	Coenzyme A binding pocket [chemical binding]; other site
357804005952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
357804005953	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
357804005954	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
357804005955	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
357804005956	FMN binding site [chemical binding]; other site
357804005957	substrate binding site [chemical binding]; other site
357804005958	putative catalytic residue [active]
357804005959	Ion transport protein; Region: Ion_trans; pfam00520
357804005960	Ion channel; Region: Ion_trans_2; pfam07885
357804005961	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
357804005962	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
357804005963	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
357804005964	DNA binding residues [nucleotide binding]
357804005965	dimer interface [polypeptide binding]; other site
357804005966	mercury binding site [ion binding]; other site
357804005967	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
357804005968	metal-binding site [ion binding]
357804005969	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
357804005970	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
357804005971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
357804005972	Nucleoside recognition; Region: Gate; pfam07670
357804005973	aromatic amino acid exporter; Provisional; Region: PRK11689
357804005974	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
357804005975	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
357804005976	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804005977	DNA-binding site [nucleotide binding]; DNA binding site
357804005978	RNA-binding motif; other site
357804005979	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
357804005980	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
357804005981	active site
357804005982	catalytic site [active]
357804005983	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
357804005984	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
357804005985	putative NAD(P) binding site [chemical binding]; other site
357804005986	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
357804005987	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
357804005988	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
357804005989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804005990	ABC-ATPase subunit interface; other site
357804005991	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
357804005992	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804005993	dimer interface [polypeptide binding]; other site
357804005994	conserved gate region; other site
357804005995	putative PBP binding loops; other site
357804005996	ABC-ATPase subunit interface; other site
357804005997	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
357804005998	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
357804005999	Walker A/P-loop; other site
357804006000	ATP binding site [chemical binding]; other site
357804006001	Q-loop/lid; other site
357804006002	ABC transporter signature motif; other site
357804006003	Walker B; other site
357804006004	D-loop; other site
357804006005	H-loop/switch region; other site
357804006006	amidophosphoribosyltransferase; Provisional; Region: PRK09246
357804006007	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
357804006008	active site
357804006009	tetramer interface [polypeptide binding]; other site
357804006010	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
357804006011	active site
357804006012	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
357804006013	Colicin V production protein; Region: Colicin_V; cl00567
357804006014	cell division protein DedD; Provisional; Region: PRK11633
357804006015	Sporulation related domain; Region: SPOR; pfam05036
357804006016	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
357804006017	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
357804006018	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
357804006019	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
357804006020	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
357804006021	dimerization interface 3.5A [polypeptide binding]; other site
357804006022	active site
357804006023	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
357804006024	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
357804006025	active site
357804006026	interdomain interaction site; other site
357804006027	putative metal-binding site [ion binding]; other site
357804006028	nucleotide binding site [chemical binding]; other site
357804006029	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
357804006030	domain I; other site
357804006031	DNA binding groove [nucleotide binding]
357804006032	phosphate binding site [ion binding]; other site
357804006033	domain II; other site
357804006034	domain III; other site
357804006035	nucleotide binding site [chemical binding]; other site
357804006036	catalytic site [active]
357804006037	domain IV; other site
357804006038	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
357804006039	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
357804006040	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
357804006041	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
357804006042	putative inner membrane peptidase; Provisional; Region: PRK11778
357804006043	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
357804006044	tandem repeat interface [polypeptide binding]; other site
357804006045	oligomer interface [polypeptide binding]; other site
357804006046	active site residues [active]
357804006047	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
357804006048	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804006049	NAD(P) binding site [chemical binding]; other site
357804006050	active site
357804006051	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
357804006052	putative acyl-acceptor binding pocket; other site
357804006053	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
357804006054	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
357804006055	domain interface [polypeptide binding]; other site
357804006056	putative active site [active]
357804006057	catalytic site [active]
357804006058	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
357804006059	domain interface [polypeptide binding]; other site
357804006060	putative active site [active]
357804006061	catalytic site [active]
357804006062	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
357804006063	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
357804006064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804006065	homodimer interface [polypeptide binding]; other site
357804006066	catalytic residue [active]
357804006067	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
357804006068	Fumarase C-terminus; Region: Fumerase_C; pfam05683
357804006069	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
357804006070	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
357804006071	chorismate binding enzyme; Region: Chorismate_bind; cl10555
357804006072	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
357804006073	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804006074	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
357804006075	substrate binding site [chemical binding]; other site
357804006076	dimerization interface [polypeptide binding]; other site
357804006077	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
357804006078	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
357804006079	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
357804006080	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
357804006081	dimer interface [polypeptide binding]; other site
357804006082	active site 1 [active]
357804006083	active site 2 [active]
357804006084	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
357804006085	tandem repeat interface [polypeptide binding]; other site
357804006086	oligomer interface [polypeptide binding]; other site
357804006087	active site residues [active]
357804006088	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
357804006089	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
357804006090	tandem repeat interface [polypeptide binding]; other site
357804006091	oligomer interface [polypeptide binding]; other site
357804006092	active site residues [active]
357804006093	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
357804006094	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
357804006095	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
357804006096	hypothetical protein; Provisional; Region: PRK04940
357804006097	beta-hexosaminidase; Provisional; Region: PRK05337
357804006098	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
357804006099	FimV N-terminal domain; Region: FimV_core; TIGR03505
357804006100	FimV N-terminal domain; Region: FimV_core; TIGR03505
357804006101	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
357804006102	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
357804006103	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
357804006104	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
357804006105	ligand binding site [chemical binding]; other site
357804006106	NAD binding site [chemical binding]; other site
357804006107	catalytic site [active]
357804006108	homodimer interface [polypeptide binding]; other site
357804006109	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
357804006110	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
357804006111	dimer interface [polypeptide binding]; other site
357804006112	active site
357804006113	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
357804006114	Uncharacterized conserved protein [Function unknown]; Region: COG4121
357804006115	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
357804006116	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
357804006117	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
357804006118	dimer interface [polypeptide binding]; other site
357804006119	active site
357804006120	CoA binding pocket [chemical binding]; other site
357804006121	haloalkane dehalogenase; Provisional; Region: PRK00870
357804006122	peptide synthase; Provisional; Region: PRK09274
357804006123	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
357804006124	acyl-activating enzyme (AAE) consensus motif; other site
357804006125	putative AMP binding site [chemical binding]; other site
357804006126	putative active site [active]
357804006127	putative CoA binding site [chemical binding]; other site
357804006128	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804006129	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
357804006130	NAD(P) binding site [chemical binding]; other site
357804006131	active site
357804006132	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
357804006133	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
357804006134	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
357804006135	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
357804006136	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
357804006137	putative metal binding site [ion binding]; other site
357804006138	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
357804006139	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
357804006140	putative metal binding site [ion binding]; other site
357804006141	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804006142	PAS fold; Region: PAS_3; pfam08447
357804006143	putative active site [active]
357804006144	heme pocket [chemical binding]; other site
357804006145	PAS domain; Region: PAS_9; pfam13426
357804006146	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804006147	metal binding site [ion binding]; metal-binding site
357804006148	active site
357804006149	I-site; other site
357804006150	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804006151	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
357804006152	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
357804006153	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
357804006154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804006155	dimer interface [polypeptide binding]; other site
357804006156	conserved gate region; other site
357804006157	putative PBP binding loops; other site
357804006158	ABC-ATPase subunit interface; other site
357804006159	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
357804006160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804006161	dimer interface [polypeptide binding]; other site
357804006162	conserved gate region; other site
357804006163	putative PBP binding loops; other site
357804006164	ABC-ATPase subunit interface; other site
357804006165	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
357804006166	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
357804006167	Walker A/P-loop; other site
357804006168	ATP binding site [chemical binding]; other site
357804006169	Q-loop/lid; other site
357804006170	ABC transporter signature motif; other site
357804006171	Walker B; other site
357804006172	D-loop; other site
357804006173	H-loop/switch region; other site
357804006174	TOBE domain; Region: TOBE_2; pfam08402
357804006175	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
357804006176	active site turn [active]
357804006177	phosphorylation site [posttranslational modification]
357804006178	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
357804006179	active site turn [active]
357804006180	phosphorylation site [posttranslational modification]
357804006181	lac repressor; Reviewed; Region: lacI; PRK09526
357804006182	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804006183	DNA binding site [nucleotide binding]
357804006184	domain linker motif; other site
357804006185	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
357804006186	ligand binding site [chemical binding]; other site
357804006187	dimerization interface (open form) [polypeptide binding]; other site
357804006188	dimerization interface (closed form) [polypeptide binding]; other site
357804006189	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
357804006190	Melibiase; Region: Melibiase; pfam02065
357804006191	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
357804006192	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
357804006193	NAD binding site [chemical binding]; other site
357804006194	homodimer interface [polypeptide binding]; other site
357804006195	active site
357804006196	substrate binding site [chemical binding]; other site
357804006197	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
357804006198	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
357804006199	dimer interface [polypeptide binding]; other site
357804006200	active site
357804006201	galactokinase; Provisional; Region: PRK05101
357804006202	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
357804006203	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
357804006204	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
357804006205	active site
357804006206	catalytic residues [active]
357804006207	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
357804006208	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
357804006209	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
357804006210	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
357804006211	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
357804006212	YHS domain; Region: YHS; pfam04945
357804006213	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
357804006214	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
357804006215	Soluble P-type ATPase [General function prediction only]; Region: COG4087
357804006216	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
357804006217	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804006218	putative active site [active]
357804006219	heme pocket [chemical binding]; other site
357804006220	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804006221	putative active site [active]
357804006222	heme pocket [chemical binding]; other site
357804006223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804006224	ATP binding site [chemical binding]; other site
357804006225	Mg2+ binding site [ion binding]; other site
357804006226	G-X-G motif; other site
357804006227	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
357804006228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804006229	active site
357804006230	phosphorylation site [posttranslational modification]
357804006231	intermolecular recognition site; other site
357804006232	dimerization interface [polypeptide binding]; other site
357804006233	Response regulator receiver domain; Region: Response_reg; pfam00072
357804006234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804006235	active site
357804006236	phosphorylation site [posttranslational modification]
357804006237	intermolecular recognition site; other site
357804006238	dimerization interface [polypeptide binding]; other site
357804006239	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804006240	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
357804006241	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
357804006242	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
357804006243	active site
357804006244	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
357804006245	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
357804006246	metal binding site [ion binding]; metal-binding site
357804006247	putative dimer interface [polypeptide binding]; other site
357804006248	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
357804006249	YheO-like PAS domain; Region: PAS_6; pfam08348
357804006250	HTH domain; Region: HTH_22; pfam13309
357804006251	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
357804006252	homotrimer interaction site [polypeptide binding]; other site
357804006253	putative active site [active]
357804006254	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
357804006255	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
357804006256	catalytic residue [active]
357804006257	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
357804006258	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
357804006259	EamA-like transporter family; Region: EamA; pfam00892
357804006260	DctM-like transporters; Region: DctM; pfam06808
357804006261	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
357804006262	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
357804006263	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
357804006264	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
357804006265	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
357804006266	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
357804006267	UDP-galactopyranose mutase; Region: GLF; pfam03275
357804006268	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
357804006269	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
357804006270	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
357804006271	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
357804006272	Transposase [DNA replication, recombination, and repair]; Region: COG5433
357804006273	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
357804006274	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
357804006275	dimerization interface [polypeptide binding]; other site
357804006276	DPS ferroxidase diiron center [ion binding]; other site
357804006277	ion pore; other site
357804006278	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804006279	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804006280	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
357804006281	putative dimerization interface [polypeptide binding]; other site
357804006282	AIR carboxylase; Region: AIRC; pfam00731
357804006283	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
357804006284	ATP-grasp domain; Region: ATP-grasp; pfam02222
357804006285	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
357804006286	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
357804006287	Sulfate transporter family; Region: Sulfate_transp; pfam00916
357804006288	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
357804006289	PAS domain; Region: PAS; smart00091
357804006290	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804006291	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804006292	putative active site [active]
357804006293	heme pocket [chemical binding]; other site
357804006294	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804006295	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804006296	metal binding site [ion binding]; metal-binding site
357804006297	active site
357804006298	I-site; other site
357804006299	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804006300	transaldolase-like protein; Provisional; Region: PTZ00411
357804006301	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
357804006302	active site
357804006303	dimer interface [polypeptide binding]; other site
357804006304	catalytic residue [active]
357804006305	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
357804006306	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
357804006307	active site
357804006308	P-loop; other site
357804006309	phosphorylation site [posttranslational modification]
357804006310	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
357804006311	active site
357804006312	phosphorylation site [posttranslational modification]
357804006313	Transcriptional regulators [Transcription]; Region: PurR; COG1609
357804006314	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804006315	DNA binding site [nucleotide binding]
357804006316	domain linker motif; other site
357804006317	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
357804006318	putative ligand binding site [chemical binding]; other site
357804006319	putative dimerization interface [polypeptide binding]; other site
357804006320	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
357804006321	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804006322	motif II; other site
357804006323	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
357804006324	Uncharacterized conserved protein [Function unknown]; Region: COG0397
357804006325	hypothetical protein; Validated; Region: PRK00029
357804006326	hypothetical protein; Provisional; Region: PRK12378
357804006327	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
357804006328	catalytic residues [active]
357804006329	dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438
357804006330	SCP-2 sterol transfer family; Region: SCP2; cl01225
357804006331	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
357804006332	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
357804006333	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
357804006334	Walker A/P-loop; other site
357804006335	ATP binding site [chemical binding]; other site
357804006336	Q-loop/lid; other site
357804006337	ABC transporter signature motif; other site
357804006338	Walker B; other site
357804006339	D-loop; other site
357804006340	H-loop/switch region; other site
357804006341	transcriptional regulator BetI; Validated; Region: PRK00767
357804006342	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
357804006343	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
357804006344	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
357804006345	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
357804006346	tetrameric interface [polypeptide binding]; other site
357804006347	NAD binding site [chemical binding]; other site
357804006348	catalytic residues [active]
357804006349	choline dehydrogenase; Validated; Region: PRK02106
357804006350	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
357804006351	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
357804006352	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
357804006353	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804006354	dimer interface [polypeptide binding]; other site
357804006355	conserved gate region; other site
357804006356	putative PBP binding loops; other site
357804006357	ABC-ATPase subunit interface; other site
357804006358	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
357804006359	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804006360	Walker A/P-loop; other site
357804006361	ATP binding site [chemical binding]; other site
357804006362	Q-loop/lid; other site
357804006363	ABC transporter signature motif; other site
357804006364	Walker B; other site
357804006365	D-loop; other site
357804006366	H-loop/switch region; other site
357804006367	BCCT family transporter; Region: BCCT; cl00569
357804006368	MarR family; Region: MarR; pfam01047
357804006369	MarR family; Region: MarR_2; cl17246
357804006370	BON domain; Region: BON; pfam04972
357804006371	Predicted flavoprotein [General function prediction only]; Region: COG0431
357804006372	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
357804006373	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
357804006374	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
357804006375	hydroxyglutarate oxidase; Provisional; Region: PRK11728
357804006376	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
357804006377	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
357804006378	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
357804006379	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
357804006380	active site
357804006381	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
357804006382	dimer interface [polypeptide binding]; other site
357804006383	substrate binding site [chemical binding]; other site
357804006384	catalytic residues [active]
357804006385	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
357804006386	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
357804006387	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804006388	ABC transporter signature motif; other site
357804006389	Walker B; other site
357804006390	D-loop; other site
357804006391	H-loop/switch region; other site
357804006392	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
357804006393	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
357804006394	PAS domain; Region: PAS; smart00091
357804006395	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804006396	putative active site [active]
357804006397	heme pocket [chemical binding]; other site
357804006398	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804006399	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804006400	putative active site [active]
357804006401	heme pocket [chemical binding]; other site
357804006402	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804006403	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804006404	metal binding site [ion binding]; metal-binding site
357804006405	active site
357804006406	I-site; other site
357804006407	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804006408	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804006409	Coenzyme A binding pocket [chemical binding]; other site
357804006410	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
357804006411	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
357804006412	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
357804006413	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
357804006414	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
357804006415	putative active site [active]
357804006416	catalytic site [active]
357804006417	putative metal binding site [ion binding]; other site
357804006418	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
357804006419	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
357804006420	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
357804006421	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804006422	dimer interface [polypeptide binding]; other site
357804006423	conserved gate region; other site
357804006424	putative PBP binding loops; other site
357804006425	ABC-ATPase subunit interface; other site
357804006426	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
357804006427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804006428	dimer interface [polypeptide binding]; other site
357804006429	conserved gate region; other site
357804006430	putative PBP binding loops; other site
357804006431	ABC-ATPase subunit interface; other site
357804006432	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
357804006433	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
357804006434	Walker A/P-loop; other site
357804006435	ATP binding site [chemical binding]; other site
357804006436	Q-loop/lid; other site
357804006437	ABC transporter signature motif; other site
357804006438	Walker B; other site
357804006439	D-loop; other site
357804006440	H-loop/switch region; other site
357804006441	TOBE domain; Region: TOBE_2; pfam08402
357804006442	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
357804006443	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
357804006444	aspartate racemase; Region: asp_race; TIGR00035
357804006445	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
357804006446	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
357804006447	Protein of unknown function (DUF3185); Region: DUF3185; pfam11381
357804006448	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804006449	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
357804006450	FOG: CBS domain [General function prediction only]; Region: COG0517
357804006451	Part of AAA domain; Region: AAA_19; pfam13245
357804006452	Family description; Region: UvrD_C_2; pfam13538
357804006453	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
357804006454	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
357804006455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804006456	NAD(P) binding site [chemical binding]; other site
357804006457	active site
357804006458	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
357804006459	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
357804006460	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
357804006461	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
357804006462	Protein of unknown function, DUF393; Region: DUF393; pfam04134
357804006463	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804006464	C factor cell-cell signaling protein; Provisional; Region: PRK09009
357804006465	NAD(P) binding site [chemical binding]; other site
357804006466	active site
357804006467	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
357804006468	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
357804006469	Beta/Gamma crystallin; Region: Crystall; cl02528
357804006470	Beta/Gamma crystallin; Region: Crystall; cl02528
357804006471	Beta/Gamma crystallin; Region: Crystall; cl02528
357804006472	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
357804006473	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
357804006474	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
357804006475	Transcriptional regulators [Transcription]; Region: GntR; COG1802
357804006476	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804006477	DNA-binding site [nucleotide binding]; DNA binding site
357804006478	FCD domain; Region: FCD; pfam07729
357804006479	Isochorismatase family; Region: Isochorismatase; pfam00857
357804006480	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
357804006481	catalytic triad [active]
357804006482	dimer interface [polypeptide binding]; other site
357804006483	conserved cis-peptide bond; other site
357804006484	aconitate hydratase; Validated; Region: PRK09277
357804006485	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
357804006486	substrate binding site [chemical binding]; other site
357804006487	ligand binding site [chemical binding]; other site
357804006488	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
357804006489	substrate binding site [chemical binding]; other site
357804006490	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
357804006491	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
357804006492	putative molybdopterin cofactor binding site [chemical binding]; other site
357804006493	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
357804006494	putative molybdopterin cofactor binding site; other site
357804006495	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
357804006496	Protein of unknown function (DUF3726); Region: DUF3726; pfam12525
357804006497	BCCT family transporter; Region: BCCT; pfam02028
357804006498	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
357804006499	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
357804006500	active site
357804006501	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
357804006502	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
357804006503	NAD(P) binding site [chemical binding]; other site
357804006504	catalytic residues [active]
357804006505	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
357804006506	homotrimer interaction site [polypeptide binding]; other site
357804006507	putative active site [active]
357804006508	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804006509	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804006510	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
357804006511	putative dimerization interface [polypeptide binding]; other site
357804006512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804006513	Major Facilitator Superfamily; Region: MFS_1; pfam07690
357804006514	putative substrate translocation pore; other site
357804006515	muropeptide transporter; Validated; Region: ampG; cl17669
357804006516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804006517	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
357804006518	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
357804006519	putative ligand binding site [chemical binding]; other site
357804006520	NAD binding site [chemical binding]; other site
357804006521	dimerization interface [polypeptide binding]; other site
357804006522	catalytic site [active]
357804006523	Methyltransferase domain; Region: Methyltransf_23; pfam13489
357804006524	Methyltransferase domain; Region: Methyltransf_11; pfam08241
357804006525	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
357804006526	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
357804006527	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
357804006528	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804006529	Response regulator receiver domain; Region: Response_reg; pfam00072
357804006530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804006531	active site
357804006532	phosphorylation site [posttranslational modification]
357804006533	intermolecular recognition site; other site
357804006534	dimerization interface [polypeptide binding]; other site
357804006535	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
357804006536	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
357804006537	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804006538	putative active site [active]
357804006539	heme pocket [chemical binding]; other site
357804006540	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804006541	dimer interface [polypeptide binding]; other site
357804006542	phosphorylation site [posttranslational modification]
357804006543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804006544	ATP binding site [chemical binding]; other site
357804006545	Mg2+ binding site [ion binding]; other site
357804006546	G-X-G motif; other site
357804006547	Response regulator receiver domain; Region: Response_reg; pfam00072
357804006548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804006549	active site
357804006550	phosphorylation site [posttranslational modification]
357804006551	intermolecular recognition site; other site
357804006552	dimerization interface [polypeptide binding]; other site
357804006553	Hpt domain; Region: Hpt; pfam01627
357804006554	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
357804006555	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
357804006556	dimer interface [polypeptide binding]; other site
357804006557	active site
357804006558	heme binding site [chemical binding]; other site
357804006559	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
357804006560	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
357804006561	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
357804006562	active site
357804006563	M6 family metalloprotease domain; Region: M6dom_TIGR03296
357804006564	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
357804006565	EamA-like transporter family; Region: EamA; pfam00892
357804006566	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804006567	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804006568	metal binding site [ion binding]; metal-binding site
357804006569	active site
357804006570	I-site; other site
357804006571	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
357804006572	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
357804006573	G1 box; other site
357804006574	GTP/Mg2+ binding site [chemical binding]; other site
357804006575	G2 box; other site
357804006576	G3 box; other site
357804006577	Switch II region; other site
357804006578	G4 box; other site
357804006579	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
357804006580	G1 box; other site
357804006581	GTP/Mg2+ binding site [chemical binding]; other site
357804006582	G2 box; other site
357804006583	Switch I region; other site
357804006584	G3 box; other site
357804006585	Switch II region; other site
357804006586	G4 box; other site
357804006587	PAS fold; Region: PAS_3; pfam08447
357804006588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804006589	heme pocket [chemical binding]; other site
357804006590	putative active site [active]
357804006591	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804006592	metal binding site [ion binding]; metal-binding site
357804006593	active site
357804006594	I-site; other site
357804006595	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804006596	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
357804006597	EamA-like transporter family; Region: EamA; pfam00892
357804006598	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804006599	DNA-binding site [nucleotide binding]; DNA binding site
357804006600	RNA-binding motif; other site
357804006601	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
357804006602	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
357804006603	glutathionine S-transferase; Provisional; Region: PRK10542
357804006604	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
357804006605	C-terminal domain interface [polypeptide binding]; other site
357804006606	dimer interface [polypeptide binding]; other site
357804006607	GSH binding site (G-site) [chemical binding]; other site
357804006608	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
357804006609	N-terminal domain interface [polypeptide binding]; other site
357804006610	dimer interface [polypeptide binding]; other site
357804006611	substrate binding pocket (H-site) [chemical binding]; other site
357804006612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804006613	Tetratricopeptide repeat; Region: TPR_16; pfam13432
357804006614	binding surface
357804006615	TPR motif; other site
357804006616	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
357804006617	Transglycosylase; Region: Transgly; pfam00912
357804006618	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
357804006619	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
357804006620	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804006621	Walker A/P-loop; other site
357804006622	ATP binding site [chemical binding]; other site
357804006623	Q-loop/lid; other site
357804006624	ABC transporter signature motif; other site
357804006625	Walker B; other site
357804006626	D-loop; other site
357804006627	H-loop/switch region; other site
357804006628	TOBE domain; Region: TOBE; pfam03459
357804006629	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
357804006630	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804006631	dimer interface [polypeptide binding]; other site
357804006632	putative PBP binding loops; other site
357804006633	ABC-ATPase subunit interface; other site
357804006634	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
357804006635	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
357804006636	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
357804006637	MoaE homodimer interface [polypeptide binding]; other site
357804006638	MoaD interaction [polypeptide binding]; other site
357804006639	active site residues [active]
357804006640	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
357804006641	MoaE interaction surface [polypeptide binding]; other site
357804006642	MoeB interaction surface [polypeptide binding]; other site
357804006643	thiocarboxylated glycine; other site
357804006644	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
357804006645	trimer interface [polypeptide binding]; other site
357804006646	dimer interface [polypeptide binding]; other site
357804006647	putative active site [active]
357804006648	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
357804006649	MPT binding site; other site
357804006650	trimer interface [polypeptide binding]; other site
357804006651	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
357804006652	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
357804006653	GTP binding site; other site
357804006654	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
357804006655	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
357804006656	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
357804006657	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
357804006658	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
357804006659	[4Fe-4S] binding site [ion binding]; other site
357804006660	molybdopterin cofactor binding site; other site
357804006661	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
357804006662	molybdopterin cofactor binding site; other site
357804006663	NapD protein; Region: NapD; pfam03927
357804006664	ferredoxin-type protein; Provisional; Region: PRK10194
357804006665	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
357804006666	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
357804006667	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804006668	FeS/SAM binding site; other site
357804006669	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
357804006670	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
357804006671	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
357804006672	DEAD_2; Region: DEAD_2; pfam06733
357804006673	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
357804006674	hypothetical protein; Provisional; Region: PRK10621
357804006675	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
357804006676	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
357804006677	Protein of unknown function (DUF2496); Region: DUF2496; pfam10689
357804006678	Acylphosphatase; Region: Acylphosphatase; pfam00708
357804006679	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
357804006680	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
357804006681	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
357804006682	active site
357804006683	HIGH motif; other site
357804006684	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
357804006685	KMSKS motif; other site
357804006686	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
357804006687	tRNA binding surface [nucleotide binding]; other site
357804006688	anticodon binding site; other site
357804006689	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
357804006690	substrate binding site [chemical binding]; other site
357804006691	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
357804006692	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
357804006693	putative active site [active]
357804006694	putative metal binding site [ion binding]; other site
357804006695	carboxy-terminal protease; Provisional; Region: PRK11186
357804006696	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
357804006697	protein binding site [polypeptide binding]; other site
357804006698	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
357804006699	Catalytic dyad [active]
357804006700	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
357804006701	ProP expression regulator; Provisional; Region: PRK04950
357804006702	ProQ/FINO family; Region: ProQ; smart00945
357804006703	putative protease; Provisional; Region: PRK15452
357804006704	Peptidase family U32; Region: Peptidase_U32; pfam01136
357804006705	ferredoxin; Validated; Region: PRK07118
357804006706	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
357804006707	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
357804006708	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
357804006709	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
357804006710	peptide binding site [polypeptide binding]; other site
357804006711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804006712	dimer interface [polypeptide binding]; other site
357804006713	conserved gate region; other site
357804006714	putative PBP binding loops; other site
357804006715	ABC-ATPase subunit interface; other site
357804006716	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
357804006717	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
357804006718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804006719	putative PBP binding loops; other site
357804006720	ABC-ATPase subunit interface; other site
357804006721	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
357804006722	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804006723	Walker A/P-loop; other site
357804006724	ATP binding site [chemical binding]; other site
357804006725	Q-loop/lid; other site
357804006726	ABC transporter signature motif; other site
357804006727	Walker B; other site
357804006728	D-loop; other site
357804006729	H-loop/switch region; other site
357804006730	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
357804006731	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
357804006732	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804006733	Walker A/P-loop; other site
357804006734	ATP binding site [chemical binding]; other site
357804006735	Q-loop/lid; other site
357804006736	ABC transporter signature motif; other site
357804006737	Walker B; other site
357804006738	D-loop; other site
357804006739	H-loop/switch region; other site
357804006740	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804006741	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804006742	active site
357804006743	I-site; other site
357804006744	metal binding site [ion binding]; metal-binding site
357804006745	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804006746	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
357804006747	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
357804006748	Ligand Binding Site [chemical binding]; other site
357804006749	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
357804006750	triosephosphate isomerase; Provisional; Region: PRK14567
357804006751	substrate binding site [chemical binding]; other site
357804006752	dimer interface [polypeptide binding]; other site
357804006753	catalytic triad [active]
357804006754	YccA-like proteins; Region: YccA_like; cd10433
357804006755	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
357804006756	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
357804006757	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
357804006758	FtsX-like permease family; Region: FtsX; pfam02687
357804006759	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
357804006760	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
357804006761	Walker A/P-loop; other site
357804006762	ATP binding site [chemical binding]; other site
357804006763	Q-loop/lid; other site
357804006764	ABC transporter signature motif; other site
357804006765	Walker B; other site
357804006766	D-loop; other site
357804006767	H-loop/switch region; other site
357804006768	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
357804006769	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
357804006770	FtsX-like permease family; Region: FtsX; pfam02687
357804006771	transcription-repair coupling factor; Provisional; Region: PRK10689
357804006772	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
357804006773	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804006774	ATP binding site [chemical binding]; other site
357804006775	putative Mg++ binding site [ion binding]; other site
357804006776	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804006777	nucleotide binding region [chemical binding]; other site
357804006778	ATP-binding site [chemical binding]; other site
357804006779	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
357804006780	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
357804006781	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cl07944
357804006782	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
357804006783	RNA binding site [nucleotide binding]; other site
357804006784	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804006785	motif II; other site
357804006786	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
357804006787	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
357804006788	RNA binding surface [nucleotide binding]; other site
357804006789	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
357804006790	active site
357804006791	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
357804006792	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
357804006793	homodimer interface [polypeptide binding]; other site
357804006794	oligonucleotide binding site [chemical binding]; other site
357804006795	thioredoxin reductase; Provisional; Region: PRK10262
357804006796	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
357804006797	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
357804006798	lipoprotein NlpI; Provisional; Region: PRK11189
357804006799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804006800	binding surface
357804006801	TPR motif; other site
357804006802	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
357804006803	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
357804006804	Protein export membrane protein; Region: SecD_SecF; pfam02355
357804006805	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
357804006806	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
357804006807	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
357804006808	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
357804006809	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
357804006810	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
357804006811	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
357804006812	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
357804006813	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
357804006814	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
357804006815	23S rRNA binding site [nucleotide binding]; other site
357804006816	L21 binding site [polypeptide binding]; other site
357804006817	L13 binding site [polypeptide binding]; other site
357804006818	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
357804006819	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
357804006820	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
357804006821	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
357804006822	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
357804006823	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
357804006824	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
357804006825	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
357804006826	active site
357804006827	dimer interface [polypeptide binding]; other site
357804006828	motif 1; other site
357804006829	motif 2; other site
357804006830	motif 3; other site
357804006831	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
357804006832	anticodon binding site; other site
357804006833	YebG protein; Region: YebG; pfam07130
357804006834	Paraquat-inducible protein A; Region: PqiA; pfam04403
357804006835	Paraquat-inducible protein A; Region: PqiA; pfam04403
357804006836	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
357804006837	mce related protein; Region: MCE; pfam02470
357804006838	mce related protein; Region: MCE; pfam02470
357804006839	mce related protein; Region: MCE; pfam02470
357804006840	mce related protein; Region: MCE; pfam02470
357804006841	mce related protein; Region: MCE; pfam02470
357804006842	mce related protein; Region: MCE; pfam02470
357804006843	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
357804006844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804006845	S-adenosylmethionine binding site [chemical binding]; other site
357804006846	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
357804006847	Uncharacterized conserved protein [Function unknown]; Region: COG1434
357804006848	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
357804006849	putative active site [active]
357804006850	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
357804006851	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
357804006852	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
357804006853	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
357804006854	Ligand Binding Site [chemical binding]; other site
357804006855	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
357804006856	active site residue [active]
357804006857	YaeQ protein; Region: YaeQ; pfam07152
357804006858	tartrate dehydrogenase; Region: TTC; TIGR02089
357804006859	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
357804006860	Uncharacterized conserved protein [Function unknown]; Region: COG0327
357804006861	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
357804006862	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
357804006863	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
357804006864	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804006865	dimer interface [polypeptide binding]; other site
357804006866	phosphorylation site [posttranslational modification]
357804006867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804006868	ATP binding site [chemical binding]; other site
357804006869	Mg2+ binding site [ion binding]; other site
357804006870	G-X-G motif; other site
357804006871	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
357804006872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804006873	active site
357804006874	phosphorylation site [posttranslational modification]
357804006875	intermolecular recognition site; other site
357804006876	dimerization interface [polypeptide binding]; other site
357804006877	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
357804006878	DNA binding site [nucleotide binding]
357804006879	Putative exonuclease, RdgC; Region: RdgC; pfam04381
357804006880	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
357804006881	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804006882	ATP-grasp domain; Region: ATP-grasp; pfam02222
357804006883	Cell division inhibitor SulA; Region: SulA; cl01880
357804006884	Uncharacterized protein family (UPF0253); Region: UPF0253; pfam06786
357804006885	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
357804006886	ATP binding site [chemical binding]; other site
357804006887	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
357804006888	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
357804006889	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
357804006890	substrate binding pocket [chemical binding]; other site
357804006891	chain length determination region; other site
357804006892	substrate-Mg2+ binding site; other site
357804006893	catalytic residues [active]
357804006894	aspartate-rich region 1; other site
357804006895	active site lid residues [active]
357804006896	aspartate-rich region 2; other site
357804006897	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
357804006898	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
357804006899	TPP-binding site; other site
357804006900	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
357804006901	PYR/PP interface [polypeptide binding]; other site
357804006902	dimer interface [polypeptide binding]; other site
357804006903	TPP binding site [chemical binding]; other site
357804006904	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
357804006905	thiamine monophosphate kinase; Provisional; Region: PRK05731
357804006906	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
357804006907	ATP binding site [chemical binding]; other site
357804006908	dimerization interface [polypeptide binding]; other site
357804006909	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
357804006910	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
357804006911	RNA binding surface [nucleotide binding]; other site
357804006912	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
357804006913	probable active site [active]
357804006914	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
357804006915	Protein of unknown function (DUF3622); Region: DUF3622; pfam12286
357804006916	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
357804006917	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
357804006918	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
357804006919	dimer interface [polypeptide binding]; other site
357804006920	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
357804006921	metal binding site [ion binding]; metal-binding site
357804006922	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
357804006923	CoA binding domain; Region: CoA_binding; pfam02629
357804006924	CoA-ligase; Region: Ligase_CoA; pfam00549
357804006925	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
357804006926	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
357804006927	CoA-ligase; Region: Ligase_CoA; pfam00549
357804006928	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
357804006929	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
357804006930	E3 interaction surface; other site
357804006931	lipoyl attachment site [posttranslational modification]; other site
357804006932	e3 binding domain; Region: E3_binding; pfam02817
357804006933	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
357804006934	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
357804006935	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
357804006936	TPP-binding site [chemical binding]; other site
357804006937	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
357804006938	dimer interface [polypeptide binding]; other site
357804006939	PYR/PP interface [polypeptide binding]; other site
357804006940	TPP binding site [chemical binding]; other site
357804006941	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
357804006942	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
357804006943	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
357804006944	L-aspartate oxidase; Provisional; Region: PRK06175
357804006945	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
357804006946	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
357804006947	SdhC subunit interface [polypeptide binding]; other site
357804006948	proximal heme binding site [chemical binding]; other site
357804006949	cardiolipin binding site; other site
357804006950	Iron-sulfur protein interface; other site
357804006951	proximal quinone binding site [chemical binding]; other site
357804006952	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
357804006953	Iron-sulfur protein interface; other site
357804006954	proximal quinone binding site [chemical binding]; other site
357804006955	SdhD (CybS) interface [polypeptide binding]; other site
357804006956	proximal heme binding site [chemical binding]; other site
357804006957	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
357804006958	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
357804006959	dimer interface [polypeptide binding]; other site
357804006960	active site
357804006961	citrylCoA binding site [chemical binding]; other site
357804006962	NADH binding [chemical binding]; other site
357804006963	cationic pore residues; other site
357804006964	oxalacetate/citrate binding site [chemical binding]; other site
357804006965	coenzyme A binding site [chemical binding]; other site
357804006966	catalytic triad [active]
357804006967	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
357804006968	FOG: CBS domain [General function prediction only]; Region: COG0517
357804006969	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
357804006970	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
357804006971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
357804006972	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
357804006973	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
357804006974	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
357804006975	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
357804006976	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
357804006977	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
357804006978	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
357804006979	nucleotide binding site/active site [active]
357804006980	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
357804006981	Nucleoid-associated protein [General function prediction only]; Region: COG3081
357804006982	nucleoid-associated protein NdpA; Validated; Region: PRK00378
357804006983	Protein of unknown function (DUF1414); Region: DUF1414; cl01175
357804006984	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
357804006985	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
357804006986	Sulfatase; Region: Sulfatase; cl17466
357804006987	exoribonuclease II; Provisional; Region: PRK05054
357804006988	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
357804006989	RNB domain; Region: RNB; pfam00773
357804006990	hypothetical protein; Provisional; Region: PRK01254
357804006991	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
357804006992	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
357804006993	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
357804006994	recombination protein RecR; Reviewed; Region: recR; PRK00076
357804006995	RecR protein; Region: RecR; pfam02132
357804006996	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
357804006997	putative active site [active]
357804006998	putative metal-binding site [ion binding]; other site
357804006999	tetramer interface [polypeptide binding]; other site
357804007000	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804007001	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804007002	metal binding site [ion binding]; metal-binding site
357804007003	active site
357804007004	I-site; other site
357804007005	hypothetical protein; Validated; Region: PRK00153
357804007006	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
357804007007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804007008	Walker A motif; other site
357804007009	ATP binding site [chemical binding]; other site
357804007010	Walker B motif; other site
357804007011	DNA polymerase III subunit delta'; Validated; Region: PRK08485
357804007012	arginine finger; other site
357804007013	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
357804007014	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
357804007015	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
357804007016	active site
357804007017	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
357804007018	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
357804007019	FMN binding site [chemical binding]; other site
357804007020	active site
357804007021	catalytic residues [active]
357804007022	substrate binding site [chemical binding]; other site
357804007023	Protein of unknown function (DUF3466); Region: DUF3466; pfam11949
357804007024	ABC transporter ATPase component; Reviewed; Region: PRK11147
357804007025	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804007026	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804007027	ABC transporter; Region: ABC_tran_2; pfam12848
357804007028	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804007029	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
357804007030	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
357804007031	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
357804007032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804007033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804007034	S-adenosylmethionine binding site [chemical binding]; other site
357804007035	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
357804007036	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
357804007037	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
357804007038	dimerization interface [polypeptide binding]; other site
357804007039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804007040	ATP binding site [chemical binding]; other site
357804007041	Mg2+ binding site [ion binding]; other site
357804007042	G-X-G motif; other site
357804007043	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
357804007044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804007045	active site
357804007046	phosphorylation site [posttranslational modification]
357804007047	intermolecular recognition site; other site
357804007048	dimerization interface [polypeptide binding]; other site
357804007049	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
357804007050	DNA binding site [nucleotide binding]
357804007051	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
357804007052	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
357804007053	inhibitor-cofactor binding pocket; inhibition site
357804007054	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804007055	catalytic residue [active]
357804007056	tyrosine decarboxylase; Region: PLN02880
357804007057	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
357804007058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804007059	catalytic residue [active]
357804007060	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
357804007061	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
357804007062	NAD(P) binding pocket [chemical binding]; other site
357804007063	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
357804007064	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
357804007065	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
357804007066	dimer interface [polypeptide binding]; other site
357804007067	active site
357804007068	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
357804007069	catalytic residues [active]
357804007070	substrate binding site [chemical binding]; other site
357804007071	PAS fold; Region: PAS_4; pfam08448
357804007072	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804007073	putative active site [active]
357804007074	heme pocket [chemical binding]; other site
357804007075	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804007076	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804007077	metal binding site [ion binding]; metal-binding site
357804007078	active site
357804007079	I-site; other site
357804007080	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
357804007081	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
357804007082	tetramer interface [polypeptide binding]; other site
357804007083	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804007084	catalytic residue [active]
357804007085	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
357804007086	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
357804007087	catalytic residues [active]
357804007088	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
357804007089	active site
357804007090	substrate binding pocket [chemical binding]; other site
357804007091	dimer interface [polypeptide binding]; other site
357804007092	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
357804007093	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
357804007094	PhnA protein; Region: PhnA; pfam03831
357804007095	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
357804007096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804007097	S-adenosylmethionine binding site [chemical binding]; other site
357804007098	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
357804007099	Na2 binding site [ion binding]; other site
357804007100	putative substrate binding site 1 [chemical binding]; other site
357804007101	Na binding site 1 [ion binding]; other site
357804007102	putative substrate binding site 2 [chemical binding]; other site
357804007103	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
357804007104	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
357804007105	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
357804007106	quinone interaction residues [chemical binding]; other site
357804007107	active site
357804007108	catalytic residues [active]
357804007109	FMN binding site [chemical binding]; other site
357804007110	substrate binding site [chemical binding]; other site
357804007111	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
357804007112	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
357804007113	Glycoprotease family; Region: Peptidase_M22; pfam00814
357804007114	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
357804007115	DEAD/DEAH box helicase; Region: DEAD; pfam00270
357804007116	ATP binding site [chemical binding]; other site
357804007117	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
357804007118	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
357804007119	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
357804007120	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804007121	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804007122	putative active site [active]
357804007123	heme pocket [chemical binding]; other site
357804007124	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804007125	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804007126	metal binding site [ion binding]; metal-binding site
357804007127	active site
357804007128	I-site; other site
357804007129	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804007130	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
357804007131	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
357804007132	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
357804007133	acetolactate synthase; Reviewed; Region: PRK08322
357804007134	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
357804007135	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
357804007136	active site
357804007137	FMN binding site [chemical binding]; other site
357804007138	substrate binding site [chemical binding]; other site
357804007139	3Fe-4S cluster binding site [ion binding]; other site
357804007140	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
357804007141	MarR family; Region: MarR; pfam01047
357804007142	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
357804007143	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
357804007144	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
357804007145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804007146	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
357804007147	dimerization interface [polypeptide binding]; other site
357804007148	substrate binding pocket [chemical binding]; other site
357804007149	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
357804007150	amphi-Trp domain; Region: amphi-Trp; TIGR04354
357804007151	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
357804007152	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
357804007153	catalytic core [active]
357804007154	HprK-related kinase B; Region: HprK_rel_B; TIGR04355
357804007155	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
357804007156	active site
357804007157	metal-binding site [ion binding]
357804007158	nucleotide-binding site [chemical binding]; other site
357804007159	ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356
357804007160	ATP-grasp domain; Region: ATP-grasp_4; cl17255
357804007161	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
357804007162	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
357804007163	Fasciclin domain; Region: Fasciclin; pfam02469
357804007164	Chromate transporter; Region: Chromate_transp; pfam02417
357804007165	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
357804007166	Chromate transporter; Region: Chromate_transp; pfam02417
357804007167	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
357804007168	Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926
357804007169	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
357804007170	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
357804007171	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804007172	Walker A/P-loop; other site
357804007173	ATP binding site [chemical binding]; other site
357804007174	Q-loop/lid; other site
357804007175	ABC transporter signature motif; other site
357804007176	Walker B; other site
357804007177	D-loop; other site
357804007178	H-loop/switch region; other site
357804007179	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
357804007180	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
357804007181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804007182	Walker A/P-loop; other site
357804007183	ATP binding site [chemical binding]; other site
357804007184	Q-loop/lid; other site
357804007185	ABC transporter signature motif; other site
357804007186	Walker B; other site
357804007187	D-loop; other site
357804007188	H-loop/switch region; other site
357804007189	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
357804007190	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
357804007191	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
357804007192	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
357804007193	nucleotide binding pocket [chemical binding]; other site
357804007194	K-X-D-G motif; other site
357804007195	catalytic site [active]
357804007196	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
357804007197	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
357804007198	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
357804007199	Dimer interface [polypeptide binding]; other site
357804007200	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
357804007201	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
357804007202	FtsZ protein binding site [polypeptide binding]; other site
357804007203	putative sulfate transport protein CysZ; Validated; Region: PRK04949
357804007204	Response regulator receiver domain; Region: Response_reg; pfam00072
357804007205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804007206	active site
357804007207	phosphorylation site [posttranslational modification]
357804007208	intermolecular recognition site; other site
357804007209	dimerization interface [polypeptide binding]; other site
357804007210	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
357804007211	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
357804007212	transmembrane helices; other site
357804007213	Response regulator receiver domain; Region: Response_reg; pfam00072
357804007214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804007215	active site
357804007216	phosphorylation site [posttranslational modification]
357804007217	intermolecular recognition site; other site
357804007218	dimerization interface [polypeptide binding]; other site
357804007219	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
357804007220	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
357804007221	transmembrane helices; other site
357804007222	aminopeptidase N; Provisional; Region: pepN; PRK14015
357804007223	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
357804007224	active site
357804007225	Zn binding site [ion binding]; other site
357804007226	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
357804007227	CoA binding domain; Region: CoA_binding_2; pfam13380
357804007228	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
357804007229	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
357804007230	multidrug efflux protein; Reviewed; Region: PRK01766
357804007231	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
357804007232	cation binding site [ion binding]; other site
357804007233	glycogen synthase; Provisional; Region: glgA; PRK00654
357804007234	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
357804007235	ADP-binding pocket [chemical binding]; other site
357804007236	homodimer interface [polypeptide binding]; other site
357804007237	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
357804007238	NADPH bind site [chemical binding]; other site
357804007239	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
357804007240	putative FMN binding site [chemical binding]; other site
357804007241	NADPH bind site [chemical binding]; other site
357804007242	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
357804007243	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
357804007244	Substrate binding site [chemical binding]; other site
357804007245	Leucine rich repeat; Region: LRR_8; pfam13855
357804007246	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
357804007247	active site
357804007248	ATP binding site [chemical binding]; other site
357804007249	substrate binding site [chemical binding]; other site
357804007250	activation loop (A-loop); other site
357804007251	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
357804007252	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
357804007253	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
357804007254	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
357804007255	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
357804007256	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
357804007257	Soluble P-type ATPase [General function prediction only]; Region: COG4087
357804007258	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
357804007259	glucokinase; Provisional; Region: glk; PRK00292
357804007260	glucokinase, proteobacterial type; Region: glk; TIGR00749
357804007261	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
357804007262	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
357804007263	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
357804007264	putative active site [active]
357804007265	pyruvate kinase; Provisional; Region: PRK05826
357804007266	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
357804007267	domain interfaces; other site
357804007268	active site
357804007269	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
357804007270	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
357804007271	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
357804007272	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
357804007273	active site
357804007274	catalytic site [active]
357804007275	glycogen branching enzyme; Provisional; Region: PRK05402
357804007276	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
357804007277	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
357804007278	active site
357804007279	catalytic site [active]
357804007280	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
357804007281	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
357804007282	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
357804007283	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
357804007284	active site
357804007285	phosphate binding residues; other site
357804007286	catalytic residues [active]
357804007287	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
357804007288	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
357804007289	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
357804007290	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
357804007291	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
357804007292	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
357804007293	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
357804007294	Protein of unknown function DUF58; Region: DUF58; pfam01882
357804007295	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804007296	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
357804007297	Walker A motif; other site
357804007298	ATP binding site [chemical binding]; other site
357804007299	Walker B motif; other site
357804007300	arginine finger; other site
357804007301	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
357804007302	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
357804007303	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
357804007304	thiamine phosphate binding site [chemical binding]; other site
357804007305	active site
357804007306	pyrophosphate binding site [ion binding]; other site
357804007307	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
357804007308	substrate binding site [chemical binding]; other site
357804007309	multimerization interface [polypeptide binding]; other site
357804007310	ATP binding site [chemical binding]; other site
357804007311	Putative transcription activator [Transcription]; Region: TenA; COG0819
357804007312	NMT1/THI5 like; Region: NMT1; pfam09084
357804007313	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
357804007314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007315	dimer interface [polypeptide binding]; other site
357804007316	conserved gate region; other site
357804007317	ABC-ATPase subunit interface; other site
357804007318	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
357804007319	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804007320	Walker A/P-loop; other site
357804007321	ATP binding site [chemical binding]; other site
357804007322	Q-loop/lid; other site
357804007323	ABC transporter signature motif; other site
357804007324	Walker B; other site
357804007325	D-loop; other site
357804007326	H-loop/switch region; other site
357804007327	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
357804007328	dimer interface [polypeptide binding]; other site
357804007329	substrate binding site [chemical binding]; other site
357804007330	ATP binding site [chemical binding]; other site
357804007331	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804007332	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804007333	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
357804007334	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
357804007335	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
357804007336	Ca binding site [ion binding]; other site
357804007337	active site
357804007338	catalytic site [active]
357804007339	glucokinase, proteobacterial type; Region: glk; TIGR00749
357804007340	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
357804007341	nucleotide binding site [chemical binding]; other site
357804007342	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
357804007343	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
357804007344	Ca binding site [ion binding]; other site
357804007345	active site
357804007346	catalytic site [active]
357804007347	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
357804007348	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
357804007349	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
357804007350	Transposase; Region: HTH_Tnp_1; pfam01527
357804007351	Protein of unknown function (DUF2999); Region: DUF2999; pfam11212
357804007352	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
357804007353	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
357804007354	HflX GTPase family; Region: HflX; cd01878
357804007355	G1 box; other site
357804007356	GTP/Mg2+ binding site [chemical binding]; other site
357804007357	Switch I region; other site
357804007358	G2 box; other site
357804007359	G3 box; other site
357804007360	Switch II region; other site
357804007361	G4 box; other site
357804007362	G5 box; other site
357804007363	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
357804007364	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
357804007365	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
357804007366	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
357804007367	Surface antigen; Region: Bac_surface_Ag; pfam01103
357804007368	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
357804007369	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
357804007370	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
357804007371	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
357804007372	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
357804007373	tetrameric interface [polypeptide binding]; other site
357804007374	NAD binding site [chemical binding]; other site
357804007375	catalytic residues [active]
357804007376	putative acyltransferase; Provisional; Region: PRK05790
357804007377	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
357804007378	dimer interface [polypeptide binding]; other site
357804007379	active site
357804007380	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
357804007381	Prostaglandin dehydrogenases; Region: PGDH; cd05288
357804007382	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
357804007383	NAD(P) binding site [chemical binding]; other site
357804007384	substrate binding site [chemical binding]; other site
357804007385	dimer interface [polypeptide binding]; other site
357804007386	Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690
357804007387	transcriptional regulator PhoU; Provisional; Region: PRK11115
357804007388	PhoU domain; Region: PhoU; pfam01895
357804007389	PhoU domain; Region: PhoU; pfam01895
357804007390	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
357804007391	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
357804007392	Walker A/P-loop; other site
357804007393	ATP binding site [chemical binding]; other site
357804007394	Q-loop/lid; other site
357804007395	ABC transporter signature motif; other site
357804007396	Walker B; other site
357804007397	D-loop; other site
357804007398	H-loop/switch region; other site
357804007399	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
357804007400	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
357804007401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007402	dimer interface [polypeptide binding]; other site
357804007403	conserved gate region; other site
357804007404	putative PBP binding loops; other site
357804007405	ABC-ATPase subunit interface; other site
357804007406	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
357804007407	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
357804007408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007409	dimer interface [polypeptide binding]; other site
357804007410	conserved gate region; other site
357804007411	putative PBP binding loops; other site
357804007412	ABC-ATPase subunit interface; other site
357804007413	PBP superfamily domain; Region: PBP_like_2; cl17296
357804007414	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804007415	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
357804007416	FOG: CBS domain [General function prediction only]; Region: COG0517
357804007417	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804007418	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804007419	metal binding site [ion binding]; metal-binding site
357804007420	active site
357804007421	exopolyphosphatase; Provisional; Region: PRK10854
357804007422	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
357804007423	nucleotide binding site [chemical binding]; other site
357804007424	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
357804007425	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
357804007426	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
357804007427	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
357804007428	domain interface [polypeptide binding]; other site
357804007429	active site
357804007430	catalytic site [active]
357804007431	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
357804007432	domain interface [polypeptide binding]; other site
357804007433	active site
357804007434	catalytic site [active]
357804007435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804007436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804007437	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
357804007438	dimerization interface [polypeptide binding]; other site
357804007439	allophanate hydrolase; Provisional; Region: PRK08186
357804007440	Amidase; Region: Amidase; cl11426
357804007441	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
357804007442	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
357804007443	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
357804007444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007445	dimer interface [polypeptide binding]; other site
357804007446	conserved gate region; other site
357804007447	ABC-ATPase subunit interface; other site
357804007448	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
357804007449	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007450	dimer interface [polypeptide binding]; other site
357804007451	conserved gate region; other site
357804007452	putative PBP binding loops; other site
357804007453	ABC-ATPase subunit interface; other site
357804007454	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
357804007455	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804007456	Walker A/P-loop; other site
357804007457	ATP binding site [chemical binding]; other site
357804007458	Q-loop/lid; other site
357804007459	ABC transporter signature motif; other site
357804007460	Walker B; other site
357804007461	D-loop; other site
357804007462	H-loop/switch region; other site
357804007463	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
357804007464	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804007465	Walker A/P-loop; other site
357804007466	ATP binding site [chemical binding]; other site
357804007467	Q-loop/lid; other site
357804007468	ABC transporter signature motif; other site
357804007469	Walker B; other site
357804007470	D-loop; other site
357804007471	H-loop/switch region; other site
357804007472	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
357804007473	allantoate amidohydrolase; Reviewed; Region: PRK09290
357804007474	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
357804007475	active site
357804007476	metal binding site [ion binding]; metal-binding site
357804007477	dimer interface [polypeptide binding]; other site
357804007478	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
357804007479	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
357804007480	catalytic residue [active]
357804007481	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
357804007482	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
357804007483	Amidase; Region: Amidase; cl11426
357804007484	indole-3-acetamide amidohydrolase; Region: PLN02722
357804007485	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
357804007486	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
357804007487	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
357804007488	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
357804007489	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
357804007490	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
357804007491	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
357804007492	Walker A/P-loop; other site
357804007493	ATP binding site [chemical binding]; other site
357804007494	Q-loop/lid; other site
357804007495	ABC transporter signature motif; other site
357804007496	Walker B; other site
357804007497	D-loop; other site
357804007498	H-loop/switch region; other site
357804007499	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
357804007500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007501	dimer interface [polypeptide binding]; other site
357804007502	conserved gate region; other site
357804007503	putative PBP binding loops; other site
357804007504	ABC-ATPase subunit interface; other site
357804007505	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
357804007506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007507	dimer interface [polypeptide binding]; other site
357804007508	conserved gate region; other site
357804007509	putative PBP binding loops; other site
357804007510	ABC-ATPase subunit interface; other site
357804007511	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
357804007512	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804007513	substrate binding pocket [chemical binding]; other site
357804007514	membrane-bound complex binding site; other site
357804007515	hinge residues; other site
357804007516	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
357804007517	EamA-like transporter family; Region: EamA; cl17759
357804007518	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
357804007519	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804007520	active site
357804007521	motif I; other site
357804007522	motif II; other site
357804007523	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
357804007524	exonuclease I; Provisional; Region: sbcB; PRK11779
357804007525	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
357804007526	active site
357804007527	catalytic site [active]
357804007528	substrate binding site [chemical binding]; other site
357804007529	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
357804007530	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
357804007531	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
357804007532	dimer interface [polypeptide binding]; other site
357804007533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804007534	catalytic residue [active]
357804007535	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
357804007536	dimerization domain swap beta strand [polypeptide binding]; other site
357804007537	regulatory protein interface [polypeptide binding]; other site
357804007538	active site
357804007539	regulatory phosphorylation site [posttranslational modification]; other site
357804007540	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
357804007541	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
357804007542	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
357804007543	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
357804007544	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
357804007545	HPr interaction site; other site
357804007546	glycerol kinase (GK) interaction site [polypeptide binding]; other site
357804007547	active site
357804007548	phosphorylation site [posttranslational modification]
357804007549	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
357804007550	ArsC family; Region: ArsC; pfam03960
357804007551	putative catalytic residues [active]
357804007552	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
357804007553	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
357804007554	metal binding site [ion binding]; metal-binding site
357804007555	dimer interface [polypeptide binding]; other site
357804007556	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
357804007557	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
357804007558	PilZ domain; Region: PilZ; pfam07238
357804007559	phosphoserine phosphatase SerB; Region: serB; TIGR00338
357804007560	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
357804007561	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804007562	motif II; other site
357804007563	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
357804007564	superoxide dismutase; Provisional; Region: PRK10543
357804007565	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
357804007566	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
357804007567	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
357804007568	putative GSH binding site [chemical binding]; other site
357804007569	catalytic residues [active]
357804007570	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
357804007571	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
357804007572	dimer interface [polypeptide binding]; other site
357804007573	catalytic site [active]
357804007574	putative active site [active]
357804007575	putative substrate binding site [chemical binding]; other site
357804007576	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
357804007577	active site
357804007578	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
357804007579	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
357804007580	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
357804007581	GTP/Mg2+ binding site [chemical binding]; other site
357804007582	G4 box; other site
357804007583	G5 box; other site
357804007584	G1 box; other site
357804007585	Switch I region; other site
357804007586	G2 box; other site
357804007587	G3 box; other site
357804007588	Switch II region; other site
357804007589	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
357804007590	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156
357804007591	putative active site [active]
357804007592	catalytic site [active]
357804007593	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162
357804007594	putative active site [active]
357804007595	catalytic site [active]
357804007596	hypothetical protein; Provisional; Region: PRK05421
357804007597	putative catalytic site [active]
357804007598	putative metal binding site [ion binding]; other site
357804007599	putative phosphate binding site [ion binding]; other site
357804007600	Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859
357804007601	putative active site [active]
357804007602	Zn binding site [ion binding]; other site
357804007603	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
357804007604	ATP-grasp domain; Region: ATP-grasp_4; cl17255
357804007605	ATP-grasp domain; Region: ATP-grasp_4; cl17255
357804007606	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
357804007607	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
357804007608	metal binding site [ion binding]; metal-binding site
357804007609	dimer interface [polypeptide binding]; other site
357804007610	DNA topoisomerase III; Provisional; Region: PRK07726
357804007611	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
357804007612	active site
357804007613	putative interdomain interaction site [polypeptide binding]; other site
357804007614	putative metal-binding site [ion binding]; other site
357804007615	putative nucleotide binding site [chemical binding]; other site
357804007616	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
357804007617	domain I; other site
357804007618	DNA binding groove [nucleotide binding]
357804007619	phosphate binding site [ion binding]; other site
357804007620	domain II; other site
357804007621	domain III; other site
357804007622	nucleotide binding site [chemical binding]; other site
357804007623	catalytic site [active]
357804007624	domain IV; other site
357804007625	integrase; Provisional; Region: PRK09692
357804007626	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
357804007627	active site
357804007628	Int/Topo IB signature motif; other site
357804007629	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
357804007630	Predicted transcriptional regulator [Transcription]; Region: COG2378
357804007631	WYL domain; Region: WYL; pfam13280
357804007632	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
357804007633	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
357804007634	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
357804007635	active site
357804007636	catalytic triad [active]
357804007637	oxyanion hole [active]
357804007638	Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413
357804007639	active site
357804007640	metal binding site [ion binding]; metal-binding site
357804007641	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
357804007642	Predicted transcriptional regulator [Transcription]; Region: COG2378
357804007643	WYL domain; Region: WYL; pfam13280
357804007644	AAA domain; Region: AAA_25; pfam13481
357804007645	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
357804007646	Walker A motif; other site
357804007647	ATP binding site [chemical binding]; other site
357804007648	Walker B motif; other site
357804007649	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
357804007650	active site
357804007651	metal binding site [ion binding]; metal-binding site
357804007652	interdomain interaction site; other site
357804007653	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
357804007654	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
357804007655	Restriction endonuclease [Defense mechanisms]; Region: COG3587
357804007656	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804007657	ATP binding site [chemical binding]; other site
357804007658	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
357804007659	DNA methylase; Region: N6_N4_Mtase; cl17433
357804007660	DNA methylase; Region: N6_N4_Mtase; pfam01555
357804007661	DNA methylase; Region: N6_N4_Mtase; cl17433
357804007662	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
357804007663	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
357804007664	putative active site [active]
357804007665	catalytic site [active]
357804007666	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
357804007667	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804007668	ATP binding site [chemical binding]; other site
357804007669	putative Mg++ binding site [ion binding]; other site
357804007670	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804007671	nucleotide binding region [chemical binding]; other site
357804007672	ATP-binding site [chemical binding]; other site
357804007673	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
357804007674	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
357804007675	ring oligomerisation interface [polypeptide binding]; other site
357804007676	ATP/Mg binding site [chemical binding]; other site
357804007677	stacking interactions; other site
357804007678	hinge regions; other site
357804007679	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
357804007680	oligomerisation interface [polypeptide binding]; other site
357804007681	mobile loop; other site
357804007682	roof hairpin; other site
357804007683	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
357804007684	integrase; Provisional; Region: PRK09692
357804007685	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
357804007686	active site
357804007687	Int/Topo IB signature motif; other site
357804007688	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
357804007689	HSP70 interaction site [polypeptide binding]; other site
357804007690	CheB methylesterase; Region: CheB_methylest; pfam01339
357804007691	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
357804007692	active site
357804007693	catalytic residues [active]
357804007694	Transcriptional regulators [Transcription]; Region: PurR; COG1609
357804007695	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804007696	DNA binding site [nucleotide binding]
357804007697	domain linker motif; other site
357804007698	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
357804007699	putative dimerization interface [polypeptide binding]; other site
357804007700	putative ligand binding site [chemical binding]; other site
357804007701	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
357804007702	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
357804007703	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
357804007704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
357804007705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007706	putative PBP binding loops; other site
357804007707	dimer interface [polypeptide binding]; other site
357804007708	ABC-ATPase subunit interface; other site
357804007709	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
357804007710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007711	dimer interface [polypeptide binding]; other site
357804007712	conserved gate region; other site
357804007713	putative PBP binding loops; other site
357804007714	ABC-ATPase subunit interface; other site
357804007715	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
357804007716	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
357804007717	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
357804007718	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
357804007719	Walker A/P-loop; other site
357804007720	ATP binding site [chemical binding]; other site
357804007721	Q-loop/lid; other site
357804007722	ABC transporter signature motif; other site
357804007723	Walker B; other site
357804007724	D-loop; other site
357804007725	H-loop/switch region; other site
357804007726	TOBE domain; Region: TOBE_2; pfam08402
357804007727	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
357804007728	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
357804007729	dimer interface [polypeptide binding]; other site
357804007730	active site
357804007731	metal binding site [ion binding]; metal-binding site
357804007732	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
357804007733	metal ion-dependent adhesion site (MIDAS); other site
357804007734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804007735	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
357804007736	Walker A motif; other site
357804007737	ATP binding site [chemical binding]; other site
357804007738	Walker B motif; other site
357804007739	arginine finger; other site
357804007740	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
357804007741	Nuclease-related domain; Region: NERD; pfam08378
357804007742	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
357804007743	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205
357804007744	PLD-like domain; Region: PLDc_2; pfam13091
357804007745	putative homodimer interface [polypeptide binding]; other site
357804007746	putative active site [active]
357804007747	catalytic site [active]
357804007748	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
357804007749	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804007750	ATP binding site [chemical binding]; other site
357804007751	putative Mg++ binding site [ion binding]; other site
357804007752	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804007753	nucleotide binding region [chemical binding]; other site
357804007754	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
357804007755	Catalytic site [active]
357804007756	Methyltransferase domain; Region: Methyltransf_23; pfam13489
357804007757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
357804007758	S-adenosylmethionine binding site [chemical binding]; other site
357804007759	Fic family protein [Function unknown]; Region: COG3177
357804007760	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
357804007761	Fic/DOC family; Region: Fic; pfam02661
357804007762	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
357804007763	CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z) is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY.  CtsZ and CtsY both have a...; Region: GH31_transferase_CtsZ; cd06598
357804007764	putative active site [active]
357804007765	putative catalytic site [active]
357804007766	Starch binding domain; Region: CBM_2; smart01065
357804007767	starch-binding site 2 [chemical binding]; other site
357804007768	starch-binding site 1 [chemical binding]; other site
357804007769	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
357804007770	Protein of unknown function (DUF3081); Region: DUF3081; pfam11280
357804007771	Protein of unknown function (DUF3081); Region: DUF3081; pfam11280
357804007772	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
357804007773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804007774	S-adenosylmethionine binding site [chemical binding]; other site
357804007775	Ferrochelatase; Region: Ferrochelatase; pfam00762
357804007776	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
357804007777	C-terminal domain interface [polypeptide binding]; other site
357804007778	active site
357804007779	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
357804007780	active site
357804007781	N-terminal domain interface [polypeptide binding]; other site
357804007782	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
357804007783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804007784	active site
357804007785	phosphorylation site [posttranslational modification]
357804007786	intermolecular recognition site; other site
357804007787	dimerization interface [polypeptide binding]; other site
357804007788	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
357804007789	DNA binding residues [nucleotide binding]
357804007790	dimerization interface [polypeptide binding]; other site
357804007791	PAS fold; Region: PAS_7; pfam12860
357804007792	PAS fold; Region: PAS_4; pfam08448
357804007793	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
357804007794	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804007795	dimer interface [polypeptide binding]; other site
357804007796	phosphorylation site [posttranslational modification]
357804007797	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804007798	ATP binding site [chemical binding]; other site
357804007799	Mg2+ binding site [ion binding]; other site
357804007800	G-X-G motif; other site
357804007801	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
357804007802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804007803	active site
357804007804	phosphorylation site [posttranslational modification]
357804007805	intermolecular recognition site; other site
357804007806	dimerization interface [polypeptide binding]; other site
357804007807	Uncharacterized conserved protein [Function unknown]; Region: COG3287
357804007808	FIST N domain; Region: FIST; pfam08495
357804007809	FIST C domain; Region: FIST_C; pfam10442
357804007810	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
357804007811	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
357804007812	NAD(P) binding site [chemical binding]; other site
357804007813	catalytic residues [active]
357804007814	ornithine cyclodeaminase; Validated; Region: PRK06141
357804007815	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
357804007816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804007817	acetoin reductases; Region: 23BDH; TIGR02415
357804007818	NAD(P) binding site [chemical binding]; other site
357804007819	active site
357804007820	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
357804007821	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
357804007822	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804007823	DNA-binding site [nucleotide binding]; DNA binding site
357804007824	RNA-binding motif; other site
357804007825	Methyltransferase domain; Region: Methyltransf_23; pfam13489
357804007826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804007827	S-adenosylmethionine binding site [chemical binding]; other site
357804007828	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
357804007829	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
357804007830	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
357804007831	active site
357804007832	Helix-turn-helix domain; Region: HTH_18; pfam12833
357804007833	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
357804007834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804007835	sugar efflux transporter; Region: 2A0120; TIGR00899
357804007836	putative substrate translocation pore; other site
357804007837	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
357804007838	CheB methylesterase; Region: CheB_methylest; pfam01339
357804007839	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
357804007840	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
357804007841	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
357804007842	PAS domain; Region: PAS_10; pfam13596
357804007843	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
357804007844	putative active site [active]
357804007845	heme pocket [chemical binding]; other site
357804007846	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804007847	PAS domain; Region: PAS_9; pfam13426
357804007848	putative active site [active]
357804007849	heme pocket [chemical binding]; other site
357804007850	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804007851	PAS domain; Region: PAS_9; pfam13426
357804007852	putative active site [active]
357804007853	heme pocket [chemical binding]; other site
357804007854	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804007855	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804007856	metal binding site [ion binding]; metal-binding site
357804007857	active site
357804007858	I-site; other site
357804007859	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
357804007860	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
357804007861	sequence-specific DNA binding site [nucleotide binding]; other site
357804007862	salt bridge; other site
357804007863	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
357804007864	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804007865	ATP binding site [chemical binding]; other site
357804007866	putative Mg++ binding site [ion binding]; other site
357804007867	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
357804007868	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
357804007869	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804007870	Walker A/P-loop; other site
357804007871	ATP binding site [chemical binding]; other site
357804007872	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
357804007873	putative active site [active]
357804007874	putative metal-binding site [ion binding]; other site
357804007875	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
357804007876	HNH endonuclease; Region: HNH_5; pfam14279
357804007877	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
357804007878	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
357804007879	Catalytic site; other site
357804007880	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
357804007881	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
357804007882	active site
357804007883	catalytic residues [active]
357804007884	DNA binding site [nucleotide binding]
357804007885	Int/Topo IB signature motif; other site
357804007886	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
357804007887	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
357804007888	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
357804007889	putative metal binding site [ion binding]; other site
357804007890	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
357804007891	putative metal binding site [ion binding]; other site
357804007892	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
357804007893	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
357804007894	putative metal binding site [ion binding]; other site
357804007895	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
357804007896	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
357804007897	putative metal binding site [ion binding]; other site
357804007898	Bacterial PH domain; Region: DUF304; pfam03703
357804007899	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804007900	FeS/SAM binding site; other site
357804007901	DNA-specific endonuclease I; Provisional; Region: PRK15137
357804007902	Endonuclease I; Region: Endonuclease_1; pfam04231
357804007903	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
357804007904	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
357804007905	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
357804007906	active site
357804007907	catalytic residues [active]
357804007908	DNA binding site [nucleotide binding]
357804007909	Int/Topo IB signature motif; other site
357804007910	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
357804007911	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
357804007912	Beta-Casp domain; Region: Beta-Casp; smart01027
357804007913	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
357804007914	PBP superfamily domain; Region: PBP_like_2; cl17296
357804007915	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
357804007916	PBP superfamily domain; Region: PBP_like_2; cl17296
357804007917	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
357804007918	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
357804007919	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007920	dimer interface [polypeptide binding]; other site
357804007921	conserved gate region; other site
357804007922	putative PBP binding loops; other site
357804007923	ABC-ATPase subunit interface; other site
357804007924	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
357804007925	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804007926	dimer interface [polypeptide binding]; other site
357804007927	conserved gate region; other site
357804007928	putative PBP binding loops; other site
357804007929	ABC-ATPase subunit interface; other site
357804007930	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14253
357804007931	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
357804007932	Walker A/P-loop; other site
357804007933	ATP binding site [chemical binding]; other site
357804007934	Q-loop/lid; other site
357804007935	ABC transporter signature motif; other site
357804007936	Walker B; other site
357804007937	D-loop; other site
357804007938	H-loop/switch region; other site
357804007939	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
357804007940	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
357804007941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804007942	S-adenosylmethionine binding site [chemical binding]; other site
357804007943	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
357804007944	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
357804007945	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
357804007946	DctM-like transporters; Region: DctM; pfam06808
357804007947	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
357804007948	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
357804007949	homodimer interface [polypeptide binding]; other site
357804007950	substrate-cofactor binding pocket; other site
357804007951	catalytic residue [active]
357804007952	MarC family integral membrane protein; Region: MarC; cl00919
357804007953	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
357804007954	Helix-turn-helix domain; Region: HTH_38; pfam13936
357804007955	Homeodomain-like domain; Region: HTH_32; pfam13565
357804007956	Integrase core domain; Region: rve; pfam00665
357804007957	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
357804007958	trehalose synthase; Region: treS_nterm; TIGR02456
357804007959	active site
357804007960	homodimer interface [polypeptide binding]; other site
357804007961	catalytic site [active]
357804007962	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
357804007963	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
357804007964	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804007965	active site
357804007966	motif I; other site
357804007967	motif II; other site
357804007968	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
357804007969	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
357804007970	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
357804007971	active site
357804007972	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
357804007973	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
357804007974	substrate binding site [chemical binding]; other site
357804007975	oxyanion hole (OAH) forming residues; other site
357804007976	trimer interface [polypeptide binding]; other site
357804007977	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
357804007978	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
357804007979	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
357804007980	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
357804007981	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
357804007982	dimer interface [polypeptide binding]; other site
357804007983	active site
357804007984	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
357804007985	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
357804007986	acyl-activating enzyme (AAE) consensus motif; other site
357804007987	putative AMP binding site [chemical binding]; other site
357804007988	putative active site [active]
357804007989	putative CoA binding site [chemical binding]; other site
357804007990	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
357804007991	dimer interface [polypeptide binding]; other site
357804007992	FMN binding site [chemical binding]; other site
357804007993	NADPH bind site [chemical binding]; other site
357804007994	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
357804007995	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
357804007996	nucleophilic elbow; other site
357804007997	catalytic triad; other site
357804007998	Protein of unknown function (DUF2960); Region: DUF2960; pfam11173
357804007999	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
357804008000	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
357804008001	30S ribosomal protein S13; Region: bact_S13; TIGR03631
357804008002	30S ribosomal protein S11; Validated; Region: PRK05309
357804008003	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
357804008004	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
357804008005	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
357804008006	RNA binding surface [nucleotide binding]; other site
357804008007	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
357804008008	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
357804008009	alphaNTD homodimer interface [polypeptide binding]; other site
357804008010	alphaNTD - beta interaction site [polypeptide binding]; other site
357804008011	alphaNTD - beta' interaction site [polypeptide binding]; other site
357804008012	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
357804008013	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
357804008014	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
357804008015	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
357804008016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804008017	Walker A/P-loop; other site
357804008018	ATP binding site [chemical binding]; other site
357804008019	Q-loop/lid; other site
357804008020	ABC transporter signature motif; other site
357804008021	Walker B; other site
357804008022	D-loop; other site
357804008023	H-loop/switch region; other site
357804008024	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
357804008025	Citrate synthase; Region: Citrate_synt; pfam00285
357804008026	oxalacetate binding site [chemical binding]; other site
357804008027	citrylCoA binding site [chemical binding]; other site
357804008028	coenzyme A binding site [chemical binding]; other site
357804008029	catalytic triad [active]
357804008030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804008031	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
357804008032	putative substrate translocation pore; other site
357804008033	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
357804008034	AMMECR1; Region: AMMECR1; pfam01871
357804008035	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
357804008036	putative ligand binding pocket/active site [active]
357804008037	putative metal binding site [ion binding]; other site
357804008038	chaperone protein DnaJ; Provisional; Region: PRK14299
357804008039	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
357804008040	HSP70 interaction site [polypeptide binding]; other site
357804008041	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
357804008042	substrate binding site [polypeptide binding]; other site
357804008043	dimer interface [polypeptide binding]; other site
357804008044	L,D-transpeptidase; Provisional; Region: PRK10190
357804008045	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804008046	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
357804008047	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
357804008048	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
357804008049	TrkA-N domain; Region: TrkA_N; pfam02254
357804008050	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
357804008051	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
357804008052	dimer interface [polypeptide binding]; other site
357804008053	active site
357804008054	hypothetical protein; Provisional; Region: PRK11212
357804008055	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
357804008056	DNA repair protein RadA; Provisional; Region: PRK11823
357804008057	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
357804008058	Walker A motif; other site
357804008059	ATP binding site [chemical binding]; other site
357804008060	Walker B motif; other site
357804008061	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
357804008062	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
357804008063	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
357804008064	metal binding triad [ion binding]; metal-binding site
357804008065	thioredoxin 2; Provisional; Region: PRK10996
357804008066	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
357804008067	catalytic residues [active]
357804008068	Pirin; Region: Pirin; pfam02678
357804008069	Pirin-related protein [General function prediction only]; Region: COG1741
357804008070	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
357804008071	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
357804008072	nucleotide binding site [chemical binding]; other site
357804008073	homotetrameric interface [polypeptide binding]; other site
357804008074	putative phosphate binding site [ion binding]; other site
357804008075	putative allosteric binding site; other site
357804008076	Methyltransferase domain; Region: Methyltransf_12; pfam08242
357804008077	S-adenosylmethionine binding site [chemical binding]; other site
357804008078	AAA domain; Region: AAA_33; pfam13671
357804008079	AAA domain; Region: AAA_17; pfam13207
357804008080	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
357804008081	Phage Tail Collar Domain; Region: Collar; pfam07484
357804008082	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
357804008083	Phage Tail Collar Domain; Region: Collar; pfam07484
357804008084	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
357804008085	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
357804008086	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
357804008087	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
357804008088	putative acyl-acceptor binding pocket; other site
357804008089	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
357804008090	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
357804008091	homotrimer interaction site [polypeptide binding]; other site
357804008092	putative active site [active]
357804008093	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
357804008094	EamA-like transporter family; Region: EamA; pfam00892
357804008095	EamA-like transporter family; Region: EamA; pfam00892
357804008096	Autoinducer synthetase; Region: Autoind_synth; cl17404
357804008097	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
357804008098	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804008099	Coenzyme A binding pocket [chemical binding]; other site
357804008100	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804008101	Major Facilitator Superfamily; Region: MFS_1; pfam07690
357804008102	putative substrate translocation pore; other site
357804008103	ammonium transporter; Region: amt; TIGR00836
357804008104	PAS domain S-box; Region: sensory_box; TIGR00229
357804008105	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804008106	putative active site [active]
357804008107	heme pocket [chemical binding]; other site
357804008108	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804008109	metal binding site [ion binding]; metal-binding site
357804008110	active site
357804008111	I-site; other site
357804008112	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804008113	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
357804008114	Helix-turn-helix domain; Region: HTH_38; pfam13936
357804008115	Homeodomain-like domain; Region: HTH_32; pfam13565
357804008116	Integrase core domain; Region: rve; pfam00665
357804008117	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
357804008118	active site
357804008119	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
357804008120	Ligand Binding Site [chemical binding]; other site
357804008121	Molecular Tunnel; other site
357804008122	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
357804008123	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
357804008124	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
357804008125	active site
357804008126	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
357804008127	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
357804008128	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804008129	Walker A/P-loop; other site
357804008130	ATP binding site [chemical binding]; other site
357804008131	Q-loop/lid; other site
357804008132	ABC transporter signature motif; other site
357804008133	Walker B; other site
357804008134	D-loop; other site
357804008135	H-loop/switch region; other site
357804008136	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
357804008137	Transposase IS200 like; Region: Y1_Tnp; pfam01797
357804008138	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
357804008139	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
357804008140	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
357804008141	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
357804008142	active site
357804008143	catalytic tetrad [active]
357804008144	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
357804008145	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
357804008146	active site
357804008147	catalytic tetrad [active]
357804008148	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804008149	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804008150	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
357804008151	putative effector binding pocket; other site
357804008152	dimerization interface [polypeptide binding]; other site
357804008153	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
357804008154	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
357804008155	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
357804008156	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
357804008157	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804008158	motif II; other site
357804008159	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
357804008160	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
357804008161	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
357804008162	catalytic triad [active]
357804008163	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
357804008164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
357804008165	SnoaL-like domain; Region: SnoaL_2; pfam12680
357804008166	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
357804008167	NADH(P)-binding; Region: NAD_binding_10; pfam13460
357804008168	NAD(P) binding site [chemical binding]; other site
357804008169	putative active site [active]
357804008170	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
357804008171	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
357804008172	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804008173	Coenzyme A binding pocket [chemical binding]; other site
357804008174	Predicted membrane protein [Function unknown]; Region: COG4325
357804008175	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
357804008176	Domain of unknown function; Region: DUF331; pfam03889
357804008177	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
357804008178	catalytic residue [active]
357804008179	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
357804008180	PLD-like domain; Region: PLDc_2; pfam13091
357804008181	putative homodimer interface [polypeptide binding]; other site
357804008182	putative active site [active]
357804008183	catalytic site [active]
357804008184	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
357804008185	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804008186	ATP binding site [chemical binding]; other site
357804008187	putative Mg++ binding site [ion binding]; other site
357804008188	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804008189	nucleotide binding region [chemical binding]; other site
357804008190	ATP-binding site [chemical binding]; other site
357804008191	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
357804008192	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
357804008193	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
357804008194	Catalytic site [active]
357804008195	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
357804008196	active site
357804008197	8-oxo-dGMP binding site [chemical binding]; other site
357804008198	nudix motif; other site
357804008199	metal binding site [ion binding]; metal-binding site
357804008200	Nuclease-related domain; Region: NERD; pfam08378
357804008201	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
357804008202	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
357804008203	AAA domain; Region: AAA_14; pfam13173
357804008204	Family description; Region: UvrD_C_2; pfam13538
357804008205	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
357804008206	nucleotide binding site [chemical binding]; other site
357804008207	putative NEF/HSP70 interaction site [polypeptide binding]; other site
357804008208	SBD interface [polypeptide binding]; other site
357804008209	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
357804008210	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
357804008211	generic binding surface I; other site
357804008212	generic binding surface II; other site
357804008213	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
357804008214	putative catalytic site [active]
357804008215	putative metal binding site [ion binding]; other site
357804008216	putative phosphate binding site [ion binding]; other site
357804008217	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
357804008218	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
357804008219	active site
357804008220	metal binding site [ion binding]; metal-binding site
357804008221	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
357804008222	Predicted permeases [General function prediction only]; Region: COG0679
357804008223	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
357804008224	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
357804008225	putative active site [active]
357804008226	Zn binding site [ion binding]; other site
357804008227	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804008228	DNA-binding site [nucleotide binding]; DNA binding site
357804008229	RNA-binding motif; other site
357804008230	Homeodomain-like domain; Region: HTH_23; pfam13384
357804008231	Winged helix-turn helix; Region: HTH_29; pfam13551
357804008232	Homeodomain-like domain; Region: HTH_32; pfam13565
357804008233	Winged helix-turn helix; Region: HTH_33; pfam13592
357804008234	DDE superfamily endonuclease; Region: DDE_3; pfam13358
357804008235	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
357804008236	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
357804008237	30S subunit binding site; other site
357804008238	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804008239	DNA-binding site [nucleotide binding]; DNA binding site
357804008240	RNA-binding motif; other site
357804008241	NMT1/THI5 like; Region: NMT1; pfam09084
357804008242	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804008243	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
357804008244	substrate binding pocket [chemical binding]; other site
357804008245	membrane-bound complex binding site; other site
357804008246	hinge residues; other site
357804008247	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804008248	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804008249	metal binding site [ion binding]; metal-binding site
357804008250	active site
357804008251	I-site; other site
357804008252	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
357804008253	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804008254	active site
357804008255	motif I; other site
357804008256	motif II; other site
357804008257	PrkA family serine protein kinase; Provisional; Region: PRK15455
357804008258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
357804008259	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
357804008260	hypothetical protein; Provisional; Region: PRK05325
357804008261	SpoVR family protein; Provisional; Region: PRK11767
357804008262	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
357804008263	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
357804008264	active site
357804008265	metal binding site [ion binding]; metal-binding site
357804008266	AAA domain; Region: AAA_33; pfam13671
357804008267	AAA domain; Region: AAA_17; pfam13207
357804008268	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
357804008269	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
357804008270	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
357804008271	UbiA prenyltransferase family; Region: UbiA; pfam01040
357804008272	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
357804008273	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
357804008274	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
357804008275	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
357804008276	Subunit III/VIIa interface [polypeptide binding]; other site
357804008277	Phospholipid binding site [chemical binding]; other site
357804008278	Subunit I/III interface [polypeptide binding]; other site
357804008279	Subunit III/VIb interface [polypeptide binding]; other site
357804008280	Subunit III/VIa interface; other site
357804008281	Subunit III/Vb interface [polypeptide binding]; other site
357804008282	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
357804008283	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
357804008284	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
357804008285	Subunit I/III interface [polypeptide binding]; other site
357804008286	D-pathway; other site
357804008287	Subunit I/VIIc interface [polypeptide binding]; other site
357804008288	Subunit I/IV interface [polypeptide binding]; other site
357804008289	Subunit I/II interface [polypeptide binding]; other site
357804008290	Low-spin heme (heme a) binding site [chemical binding]; other site
357804008291	Subunit I/VIIa interface [polypeptide binding]; other site
357804008292	Subunit I/VIa interface [polypeptide binding]; other site
357804008293	Dimer interface; other site
357804008294	Putative water exit pathway; other site
357804008295	Binuclear center (heme a3/CuB) [ion binding]; other site
357804008296	K-pathway; other site
357804008297	Putative proton exit pathway; other site
357804008298	Subunit I/VIb interface; other site
357804008299	Subunit I/VIc interface [polypeptide binding]; other site
357804008300	Electron transfer pathway; other site
357804008301	Subunit I/VIIIb interface [polypeptide binding]; other site
357804008302	Subunit I/VIIb interface [polypeptide binding]; other site
357804008303	cytochrome c oxidase subunit II; Validated; Region: COX2; MTH00023
357804008304	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
357804008305	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
357804008306	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
357804008307	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
357804008308	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
357804008309	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
357804008310	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
357804008311	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
357804008312	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
357804008313	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
357804008314	catalytic residues [active]
357804008315	hypothetical protein; Provisional; Region: PRK05423
357804008316	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
357804008317	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
357804008318	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
357804008319	cleavage site
357804008320	active site
357804008321	substrate binding sites [chemical binding]; other site
357804008322	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
357804008323	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
357804008324	ATP binding site [chemical binding]; other site
357804008325	Mg++ binding site [ion binding]; other site
357804008326	motif III; other site
357804008327	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804008328	nucleotide binding region [chemical binding]; other site
357804008329	ATP-binding site [chemical binding]; other site
357804008330	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
357804008331	putative RNA binding site [nucleotide binding]; other site
357804008332	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
357804008333	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
357804008334	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
357804008335	active site turn [active]
357804008336	phosphorylation site [posttranslational modification]
357804008337	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
357804008338	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
357804008339	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
357804008340	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
357804008341	non-specific DNA binding site [nucleotide binding]; other site
357804008342	salt bridge; other site
357804008343	sequence-specific DNA binding site [nucleotide binding]; other site
357804008344	Cupin domain; Region: Cupin_2; pfam07883
357804008345	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
357804008346	lipoyl attachment site [posttranslational modification]; other site
357804008347	glycine dehydrogenase; Provisional; Region: PRK05367
357804008348	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
357804008349	tetramer interface [polypeptide binding]; other site
357804008350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804008351	catalytic residue [active]
357804008352	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
357804008353	tetramer interface [polypeptide binding]; other site
357804008354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804008355	catalytic residue [active]
357804008356	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804008357	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804008358	metal binding site [ion binding]; metal-binding site
357804008359	active site
357804008360	I-site; other site
357804008361	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804008362	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804008363	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804008364	metal binding site [ion binding]; metal-binding site
357804008365	active site
357804008366	I-site; other site
357804008367	Cation efflux family; Region: Cation_efflux; pfam01545
357804008368	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
357804008369	Ligand Binding Site [chemical binding]; other site
357804008370	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804008371	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804008372	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
357804008373	dimerization interface [polypeptide binding]; other site
357804008374	CsiD; Region: CsiD; pfam08943
357804008375	substrate binding pocket [chemical binding]; other site
357804008376	active site
357804008377	iron coordination sites [ion binding]; other site
357804008378	hydroxyglutarate oxidase; Provisional; Region: PRK11728
357804008379	Predicted dehydrogenase [General function prediction only]; Region: COG0579
357804008380	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
357804008381	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
357804008382	transcriptional regulator protein; Region: phnR; TIGR03337
357804008383	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804008384	DNA-binding site [nucleotide binding]; DNA binding site
357804008385	UTRA domain; Region: UTRA; pfam07702
357804008386	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
357804008387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008388	dimer interface [polypeptide binding]; other site
357804008389	conserved gate region; other site
357804008390	putative PBP binding loops; other site
357804008391	ABC-ATPase subunit interface; other site
357804008392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008393	dimer interface [polypeptide binding]; other site
357804008394	conserved gate region; other site
357804008395	putative PBP binding loops; other site
357804008396	ABC-ATPase subunit interface; other site
357804008397	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
357804008398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804008399	Walker A/P-loop; other site
357804008400	ATP binding site [chemical binding]; other site
357804008401	Q-loop/lid; other site
357804008402	ABC transporter signature motif; other site
357804008403	Walker B; other site
357804008404	D-loop; other site
357804008405	H-loop/switch region; other site
357804008406	TOBE domain; Region: TOBE_2; pfam08402
357804008407	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
357804008408	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
357804008409	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
357804008410	catalytic residue [active]
357804008411	4-aminobutyrate aminotransferase; Provisional; Region: PRK06082
357804008412	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
357804008413	inhibitor-cofactor binding pocket; inhibition site
357804008414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804008415	catalytic residue [active]
357804008416	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
357804008417	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804008418	motif II; other site
357804008419	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
357804008420	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
357804008421	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
357804008422	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
357804008423	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
357804008424	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
357804008425	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
357804008426	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
357804008427	putative active site [active]
357804008428	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
357804008429	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
357804008430	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
357804008431	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
357804008432	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
357804008433	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
357804008434	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
357804008435	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
357804008436	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
357804008437	MgtE intracellular N domain; Region: MgtE_N; pfam03448
357804008438	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
357804008439	Divalent cation transporter; Region: MgtE; cl00786
357804008440	transcriptional regulator HdfR; Provisional; Region: PRK03601
357804008441	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804008442	LysR substrate binding domain; Region: LysR_substrate; pfam03466
357804008443	dimerization interface [polypeptide binding]; other site
357804008444	propionate/acetate kinase; Provisional; Region: PRK12379
357804008445	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
357804008446	pyruvate phosphate dikinase; Provisional; Region: PRK09279
357804008447	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
357804008448	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
357804008449	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
357804008450	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
357804008451	Mechanosensitive ion channel; Region: MS_channel; pfam00924
357804008452	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
357804008453	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
357804008454	putative active site [active]
357804008455	Zn binding site [ion binding]; other site
357804008456	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
357804008457	Uncharacterized conserved protein [Function unknown]; Region: COG0398
357804008458	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
357804008459	mercuric reductase; Validated; Region: PRK06370
357804008460	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
357804008461	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
357804008462	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
357804008463	hypothetical protein; Provisional; Region: PRK11622
357804008464	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
357804008465	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
357804008466	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
357804008467	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008468	dimer interface [polypeptide binding]; other site
357804008469	conserved gate region; other site
357804008470	putative PBP binding loops; other site
357804008471	ABC-ATPase subunit interface; other site
357804008472	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
357804008473	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804008474	Walker A/P-loop; other site
357804008475	ATP binding site [chemical binding]; other site
357804008476	Q-loop/lid; other site
357804008477	ABC transporter signature motif; other site
357804008478	Walker B; other site
357804008479	D-loop; other site
357804008480	H-loop/switch region; other site
357804008481	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
357804008482	Syd protein (SUKH-2); Region: Syd; pfam07348
357804008483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
357804008484	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
357804008485	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
357804008486	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
357804008487	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
357804008488	flap endonuclease-like protein; Provisional; Region: PRK09482
357804008489	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
357804008490	active site
357804008491	metal binding site 1 [ion binding]; metal-binding site
357804008492	putative 5' ssDNA interaction site; other site
357804008493	metal binding site 3; metal-binding site
357804008494	metal binding site 2 [ion binding]; metal-binding site
357804008495	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
357804008496	putative DNA binding site [nucleotide binding]; other site
357804008497	putative metal binding site [ion binding]; other site
357804008498	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804008499	acetoin reductases; Region: 23BDH; TIGR02415
357804008500	NAD(P) binding site [chemical binding]; other site
357804008501	active site
357804008502	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
357804008503	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
357804008504	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
357804008505	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
357804008506	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
357804008507	E3 interaction surface; other site
357804008508	lipoyl attachment site [posttranslational modification]; other site
357804008509	e3 binding domain; Region: E3_binding; pfam02817
357804008510	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
357804008511	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
357804008512	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
357804008513	active site
357804008514	metal binding site [ion binding]; metal-binding site
357804008515	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
357804008516	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
357804008517	tetramer interface [polypeptide binding]; other site
357804008518	TPP-binding site [chemical binding]; other site
357804008519	heterodimer interface [polypeptide binding]; other site
357804008520	phosphorylation loop region [posttranslational modification]
357804008521	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
357804008522	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
357804008523	alpha subunit interface [polypeptide binding]; other site
357804008524	TPP binding site [chemical binding]; other site
357804008525	heterodimer interface [polypeptide binding]; other site
357804008526	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
357804008527	succinic semialdehyde dehydrogenase; Region: PLN02278
357804008528	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
357804008529	tetramerization interface [polypeptide binding]; other site
357804008530	NAD(P) binding site [chemical binding]; other site
357804008531	catalytic residues [active]
357804008532	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
357804008533	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
357804008534	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
357804008535	active site
357804008536	Transcriptional regulators [Transcription]; Region: PurR; COG1609
357804008537	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804008538	DNA binding site [nucleotide binding]
357804008539	domain linker motif; other site
357804008540	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
357804008541	dimerization interface [polypeptide binding]; other site
357804008542	ligand binding site [chemical binding]; other site
357804008543	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
357804008544	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
357804008545	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
357804008546	Walker A/P-loop; other site
357804008547	ATP binding site [chemical binding]; other site
357804008548	Q-loop/lid; other site
357804008549	ABC transporter signature motif; other site
357804008550	Walker B; other site
357804008551	D-loop; other site
357804008552	H-loop/switch region; other site
357804008553	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
357804008554	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
357804008555	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
357804008556	TM-ABC transporter signature motif; other site
357804008557	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
357804008558	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
357804008559	TM-ABC transporter signature motif; other site
357804008560	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
357804008561	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317
357804008562	putative ligand binding site [chemical binding]; other site
357804008563	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
357804008564	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
357804008565	ring oligomerisation interface [polypeptide binding]; other site
357804008566	ATP/Mg binding site [chemical binding]; other site
357804008567	stacking interactions; other site
357804008568	hinge regions; other site
357804008569	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
357804008570	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
357804008571	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
357804008572	putative ligand binding site [chemical binding]; other site
357804008573	putative NAD binding site [chemical binding]; other site
357804008574	catalytic site [active]
357804008575	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
357804008576	HflC protein; Region: hflC; TIGR01932
357804008577	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
357804008578	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
357804008579	HflK protein; Region: hflK; TIGR01933
357804008580	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
357804008581	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804008582	Coenzyme A binding pocket [chemical binding]; other site
357804008583	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804008584	Major Facilitator Superfamily; Region: MFS_1; pfam07690
357804008585	putative substrate translocation pore; other site
357804008586	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804008587	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804008588	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
357804008589	dimerization interface [polypeptide binding]; other site
357804008590	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
357804008591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804008592	active site
357804008593	phosphorylation site [posttranslational modification]
357804008594	intermolecular recognition site; other site
357804008595	dimerization interface [polypeptide binding]; other site
357804008596	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
357804008597	DNA binding site [nucleotide binding]
357804008598	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
357804008599	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804008600	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
357804008601	active site
357804008602	Walker A/P-loop; other site
357804008603	ATP binding site [chemical binding]; other site
357804008604	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
357804008605	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
357804008606	putative ligand binding site [chemical binding]; other site
357804008607	PAS fold; Region: PAS_7; pfam12860
357804008608	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804008609	dimer interface [polypeptide binding]; other site
357804008610	phosphorylation site [posttranslational modification]
357804008611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804008612	ATP binding site [chemical binding]; other site
357804008613	G-X-G motif; other site
357804008614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
357804008615	active site
357804008616	phosphorylation site [posttranslational modification]
357804008617	intermolecular recognition site; other site
357804008618	dimerization interface [polypeptide binding]; other site
357804008619	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
357804008620	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
357804008621	putative ligand binding site [chemical binding]; other site
357804008622	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
357804008623	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
357804008624	TM-ABC transporter signature motif; other site
357804008625	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
357804008626	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
357804008627	Walker A/P-loop; other site
357804008628	ATP binding site [chemical binding]; other site
357804008629	Q-loop/lid; other site
357804008630	ABC transporter signature motif; other site
357804008631	Walker B; other site
357804008632	D-loop; other site
357804008633	H-loop/switch region; other site
357804008634	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
357804008635	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
357804008636	catalytic core [active]
357804008637	Protein of unknown function (Duf2374); Region: DUF2374; pfam09574
357804008638	MoxR-like ATPases [General function prediction only]; Region: COG0714
357804008639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804008640	Walker A motif; other site
357804008641	ATP binding site [chemical binding]; other site
357804008642	Walker B motif; other site
357804008643	arginine finger; other site
357804008644	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
357804008645	Protein of unknown function DUF58; Region: DUF58; pfam01882
357804008646	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
357804008647	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
357804008648	metal ion-dependent adhesion site (MIDAS); other site
357804008649	von Willebrand factor type A domain; Region: VWA_2; pfam13519
357804008650	metal ion-dependent adhesion site (MIDAS); other site
357804008651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804008652	Tetratricopeptide repeat; Region: TPR_16; pfam13432
357804008653	binding surface
357804008654	TPR motif; other site
357804008655	Oxygen tolerance; Region: BatD; pfam13584
357804008656	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
357804008657	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804008658	substrate binding pocket [chemical binding]; other site
357804008659	membrane-bound complex binding site; other site
357804008660	hinge residues; other site
357804008661	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
357804008662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008663	conserved gate region; other site
357804008664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008665	putative PBP binding loops; other site
357804008666	dimer interface [polypeptide binding]; other site
357804008667	ABC-ATPase subunit interface; other site
357804008668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008669	dimer interface [polypeptide binding]; other site
357804008670	conserved gate region; other site
357804008671	putative PBP binding loops; other site
357804008672	ABC-ATPase subunit interface; other site
357804008673	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
357804008674	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
357804008675	Walker A/P-loop; other site
357804008676	ATP binding site [chemical binding]; other site
357804008677	Q-loop/lid; other site
357804008678	ABC transporter signature motif; other site
357804008679	Walker B; other site
357804008680	D-loop; other site
357804008681	H-loop/switch region; other site
357804008682	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
357804008683	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804008684	substrate binding pocket [chemical binding]; other site
357804008685	membrane-bound complex binding site; other site
357804008686	hinge residues; other site
357804008687	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
357804008688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008689	conserved gate region; other site
357804008690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008691	putative PBP binding loops; other site
357804008692	dimer interface [polypeptide binding]; other site
357804008693	ABC-ATPase subunit interface; other site
357804008694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008695	dimer interface [polypeptide binding]; other site
357804008696	conserved gate region; other site
357804008697	putative PBP binding loops; other site
357804008698	ABC-ATPase subunit interface; other site
357804008699	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
357804008700	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
357804008701	Walker A/P-loop; other site
357804008702	ATP binding site [chemical binding]; other site
357804008703	Q-loop/lid; other site
357804008704	ABC transporter signature motif; other site
357804008705	Walker B; other site
357804008706	D-loop; other site
357804008707	H-loop/switch region; other site
357804008708	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
357804008709	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
357804008710	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
357804008711	putative active site [active]
357804008712	Zn binding site [ion binding]; other site
357804008713	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
357804008714	ATP-grasp domain; Region: ATP-grasp_4; cl17255
357804008715	Mechanosensitive ion channel; Region: MS_channel; pfam00924
357804008716	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
357804008717	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
357804008718	Cl binding site [ion binding]; other site
357804008719	oligomer interface [polypeptide binding]; other site
357804008720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008721	dimer interface [polypeptide binding]; other site
357804008722	conserved gate region; other site
357804008723	putative PBP binding loops; other site
357804008724	ABC-ATPase subunit interface; other site
357804008725	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
357804008726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
357804008727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008728	ABC-ATPase subunit interface; other site
357804008729	putative PBP binding loops; other site
357804008730	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
357804008731	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804008732	substrate binding pocket [chemical binding]; other site
357804008733	membrane-bound complex binding site; other site
357804008734	hinge residues; other site
357804008735	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
357804008736	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
357804008737	Walker A/P-loop; other site
357804008738	ATP binding site [chemical binding]; other site
357804008739	Q-loop/lid; other site
357804008740	ABC transporter signature motif; other site
357804008741	Walker B; other site
357804008742	D-loop; other site
357804008743	H-loop/switch region; other site
357804008744	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
357804008745	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
357804008746	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
357804008747	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
357804008748	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
357804008749	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
357804008750	ATP-grasp domain; Region: ATP-grasp_4; cl17255
357804008751	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
357804008752	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
357804008753	carboxyltransferase (CT) interaction site; other site
357804008754	biotinylation site [posttranslational modification]; other site
357804008755	Staphylococcal nuclease homologues; Region: SNc; smart00318
357804008756	Catalytic site; other site
357804008757	Staphylococcal nuclease homologue; Region: SNase; pfam00565
357804008758	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
357804008759	putative deacylase active site [active]
357804008760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804008761	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
357804008762	beta-galactosidase; Region: BGL; TIGR03356
357804008763	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
357804008764	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
357804008765	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804008766	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
357804008767	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
357804008768	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804008769	Walker A/P-loop; other site
357804008770	ATP binding site [chemical binding]; other site
357804008771	Q-loop/lid; other site
357804008772	ABC transporter signature motif; other site
357804008773	Walker B; other site
357804008774	D-loop; other site
357804008775	H-loop/switch region; other site
357804008776	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
357804008777	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804008778	binding surface
357804008779	Tetratricopeptide repeat; Region: TPR_16; pfam13432
357804008780	TPR motif; other site
357804008781	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
357804008782	TPR repeat; Region: TPR_11; pfam13414
357804008783	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804008784	TPR motif; other site
357804008785	binding surface
357804008786	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008787	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008788	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008789	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008790	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008791	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008792	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008793	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008794	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008795	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008796	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008797	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008798	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008799	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008800	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
357804008801	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
357804008802	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804008803	DNA-binding site [nucleotide binding]; DNA binding site
357804008804	RNA-binding motif; other site
357804008805	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
357804008806	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
357804008807	ABC1 family; Region: ABC1; pfam03109
357804008808	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
357804008809	active site
357804008810	ATP binding site [chemical binding]; other site
357804008811	Cupin domain; Region: Cupin_2; cl17218
357804008812	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
357804008813	catalytic triad [active]
357804008814	dimer interface [polypeptide binding]; other site
357804008815	myosin-cross-reactive antigen; Provisional; Region: PRK13977
357804008816	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
357804008817	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
357804008818	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
357804008819	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
357804008820	Nucleoside recognition; Region: Gate; pfam07670
357804008821	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
357804008822	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
357804008823	intersubunit interface [polypeptide binding]; other site
357804008824	active site
357804008825	catalytic residue [active]
357804008826	phosphopentomutase; Provisional; Region: PRK05362
357804008827	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
357804008828	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
357804008829	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
357804008830	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
357804008831	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
357804008832	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
357804008833	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
357804008834	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
357804008835	active site
357804008836	catalytic motif [active]
357804008837	Zn binding site [ion binding]; other site
357804008838	uridine phosphorylase; Provisional; Region: PRK11178
357804008839	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
357804008840	primosome assembly protein PriA; Validated; Region: PRK05580
357804008841	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804008842	ATP binding site [chemical binding]; other site
357804008843	putative Mg++ binding site [ion binding]; other site
357804008844	helicase superfamily c-terminal domain; Region: HELICc; smart00490
357804008845	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
357804008846	stringent starvation protein A; Provisional; Region: sspA; PRK09481
357804008847	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
357804008848	C-terminal domain interface [polypeptide binding]; other site
357804008849	putative GSH binding site (G-site) [chemical binding]; other site
357804008850	dimer interface [polypeptide binding]; other site
357804008851	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
357804008852	dimer interface [polypeptide binding]; other site
357804008853	N-terminal domain interface [polypeptide binding]; other site
357804008854	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
357804008855	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
357804008856	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
357804008857	Qi binding site; other site
357804008858	intrachain domain interface; other site
357804008859	interchain domain interface [polypeptide binding]; other site
357804008860	heme bH binding site [chemical binding]; other site
357804008861	heme bL binding site [chemical binding]; other site
357804008862	Qo binding site; other site
357804008863	interchain domain interface [polypeptide binding]; other site
357804008864	intrachain domain interface; other site
357804008865	Qi binding site; other site
357804008866	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
357804008867	Qo binding site; other site
357804008868	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
357804008869	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
357804008870	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
357804008871	[2Fe-2S] cluster binding site [ion binding]; other site
357804008872	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
357804008873	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
357804008874	23S rRNA interface [nucleotide binding]; other site
357804008875	L3 interface [polypeptide binding]; other site
357804008876	Predicted ATPase [General function prediction only]; Region: COG1485
357804008877	pyruvate kinase; Provisional; Region: PRK09206
357804008878	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
357804008879	domain interfaces; other site
357804008880	active site
357804008881	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
357804008882	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
357804008883	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
357804008884	protein binding site [polypeptide binding]; other site
357804008885	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
357804008886	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
357804008887	hinge; other site
357804008888	active site
357804008889	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
357804008890	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
357804008891	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
357804008892	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
357804008893	mce related protein; Region: MCE; pfam02470
357804008894	Permease; Region: Permease; cl00510
357804008895	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
357804008896	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
357804008897	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
357804008898	Walker A/P-loop; other site
357804008899	ATP binding site [chemical binding]; other site
357804008900	Q-loop/lid; other site
357804008901	ABC transporter signature motif; other site
357804008902	Walker B; other site
357804008903	D-loop; other site
357804008904	H-loop/switch region; other site
357804008905	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
357804008906	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804008907	active site
357804008908	motif I; other site
357804008909	motif II; other site
357804008910	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
357804008911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
357804008912	OstA-like protein; Region: OstA; cl00844
357804008913	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
357804008914	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
357804008915	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
357804008916	Walker A/P-loop; other site
357804008917	ATP binding site [chemical binding]; other site
357804008918	Q-loop/lid; other site
357804008919	ABC transporter signature motif; other site
357804008920	Walker B; other site
357804008921	D-loop; other site
357804008922	H-loop/switch region; other site
357804008923	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
357804008924	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
357804008925	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
357804008926	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
357804008927	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
357804008928	active site
357804008929	phosphorylation site [posttranslational modification]
357804008930	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
357804008931	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
357804008932	dimerization domain swap beta strand [polypeptide binding]; other site
357804008933	regulatory protein interface [polypeptide binding]; other site
357804008934	active site
357804008935	regulatory phosphorylation site [posttranslational modification]; other site
357804008936	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
357804008937	MgtE intracellular N domain; Region: MgtE_N; smart00924
357804008938	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
357804008939	Divalent cation transporter; Region: MgtE; pfam01769
357804008940	Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062
357804008941	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
357804008942	DNA binding site [nucleotide binding]
357804008943	Response regulator receiver domain; Region: Response_reg; pfam00072
357804008944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804008945	active site
357804008946	phosphorylation site [posttranslational modification]
357804008947	intermolecular recognition site; other site
357804008948	dimerization interface [polypeptide binding]; other site
357804008949	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
357804008950	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
357804008951	substrate binding site [chemical binding]; other site
357804008952	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
357804008953	substrate binding site [chemical binding]; other site
357804008954	ligand binding site [chemical binding]; other site
357804008955	heat shock protein HtpX; Provisional; Region: PRK05457
357804008956	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
357804008957	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804008958	motif II; other site
357804008959	putative S-transferase; Provisional; Region: PRK11752
357804008960	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
357804008961	C-terminal domain interface [polypeptide binding]; other site
357804008962	GSH binding site (G-site) [chemical binding]; other site
357804008963	dimer interface [polypeptide binding]; other site
357804008964	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
357804008965	dimer interface [polypeptide binding]; other site
357804008966	N-terminal domain interface [polypeptide binding]; other site
357804008967	active site
357804008968	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
357804008969	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
357804008970	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
357804008971	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
357804008972	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
357804008973	heme-binding site [chemical binding]; other site
357804008974	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
357804008975	FAD binding pocket [chemical binding]; other site
357804008976	FAD binding motif [chemical binding]; other site
357804008977	phosphate binding motif [ion binding]; other site
357804008978	beta-alpha-beta structure motif; other site
357804008979	NAD binding pocket [chemical binding]; other site
357804008980	Domain of unknown function DUF302; Region: DUF302; cl01364
357804008981	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
357804008982	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
357804008983	Ca binding site [ion binding]; other site
357804008984	active site
357804008985	catalytic site [active]
357804008986	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
357804008987	Transcriptional regulators [Transcription]; Region: PurR; COG1609
357804008988	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804008989	DNA binding site [nucleotide binding]
357804008990	domain linker motif; other site
357804008991	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
357804008992	putative dimerization interface [polypeptide binding]; other site
357804008993	putative ligand binding site [chemical binding]; other site
357804008994	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
357804008995	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804008996	dimer interface [polypeptide binding]; other site
357804008997	conserved gate region; other site
357804008998	putative PBP binding loops; other site
357804008999	ABC-ATPase subunit interface; other site
357804009000	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
357804009001	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804009002	dimer interface [polypeptide binding]; other site
357804009003	conserved gate region; other site
357804009004	putative PBP binding loops; other site
357804009005	ABC-ATPase subunit interface; other site
357804009006	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
357804009007	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
357804009008	Walker A/P-loop; other site
357804009009	ATP binding site [chemical binding]; other site
357804009010	Q-loop/lid; other site
357804009011	ABC transporter signature motif; other site
357804009012	Walker B; other site
357804009013	D-loop; other site
357804009014	H-loop/switch region; other site
357804009015	TOBE domain; Region: TOBE_2; pfam08402
357804009016	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804009017	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804009018	metal binding site [ion binding]; metal-binding site
357804009019	active site
357804009020	I-site; other site
357804009021	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
357804009022	leucine export protein LeuE; Provisional; Region: PRK10958
357804009023	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
357804009024	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
357804009025	motif I; other site
357804009026	active site
357804009027	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
357804009028	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
357804009029	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
357804009030	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
357804009031	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
357804009032	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
357804009033	E3 interaction surface; other site
357804009034	lipoyl attachment site [posttranslational modification]; other site
357804009035	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
357804009036	E3 interaction surface; other site
357804009037	lipoyl attachment site [posttranslational modification]; other site
357804009038	e3 binding domain; Region: E3_binding; pfam02817
357804009039	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
357804009040	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
357804009041	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
357804009042	dimer interface [polypeptide binding]; other site
357804009043	TPP-binding site [chemical binding]; other site
357804009044	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
357804009045	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804009046	DNA-binding site [nucleotide binding]; DNA binding site
357804009047	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
357804009048	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
357804009049	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804009050	DNA binding site [nucleotide binding]
357804009051	domain linker motif; other site
357804009052	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
357804009053	putative ligand binding site [chemical binding]; other site
357804009054	putative dimerization interface [polypeptide binding]; other site
357804009055	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
357804009056	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
357804009057	active site
357804009058	intersubunit interface [polypeptide binding]; other site
357804009059	catalytic residue [active]
357804009060	Dehydratase family; Region: ILVD_EDD; cl00340
357804009061	AAA domain; Region: AAA_33; pfam13671
357804009062	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
357804009063	ATP-binding site [chemical binding]; other site
357804009064	Gluconate-6-phosphate binding site [chemical binding]; other site
357804009065	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
357804009066	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
357804009067	DctM-like transporters; Region: DctM; pfam06808
357804009068	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
357804009069	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
357804009070	ATP-binding site [chemical binding]; other site
357804009071	Gluconate-6-phosphate binding site [chemical binding]; other site
357804009072	Shikimate kinase; Region: SKI; pfam01202
357804009073	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
357804009074	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
357804009075	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
357804009076	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
357804009077	Amidase; Region: Amidase; cl11426
357804009078	indole-3-acetamide amidohydrolase; Region: PLN02722
357804009079	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
357804009080	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
357804009081	amidase catalytic site [active]
357804009082	Zn binding residues [ion binding]; other site
357804009083	substrate binding site [chemical binding]; other site
357804009084	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
357804009085	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
357804009086	active site
357804009087	catalytic residues [active]
357804009088	DNA binding site [nucleotide binding]
357804009089	Int/Topo IB signature motif; other site
357804009090	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
357804009091	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
357804009092	active site
357804009093	catalytic residues [active]
357804009094	DNA binding site [nucleotide binding]
357804009095	Int/Topo IB signature motif; other site
357804009096	GMP synthase; Reviewed; Region: guaA; PRK00074
357804009097	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
357804009098	AMP/PPi binding site [chemical binding]; other site
357804009099	candidate oxyanion hole; other site
357804009100	catalytic triad [active]
357804009101	potential glutamine specificity residues [chemical binding]; other site
357804009102	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
357804009103	ATP Binding subdomain [chemical binding]; other site
357804009104	Ligand Binding sites [chemical binding]; other site
357804009105	Dimerization subdomain; other site
357804009106	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
357804009107	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
357804009108	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
357804009109	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
357804009110	active site
357804009111	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
357804009112	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
357804009113	generic binding surface II; other site
357804009114	generic binding surface I; other site
357804009115	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
357804009116	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
357804009117	putative catalytic cysteine [active]
357804009118	gamma-glutamyl kinase; Provisional; Region: PRK05429
357804009119	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
357804009120	nucleotide binding site [chemical binding]; other site
357804009121	homotetrameric interface [polypeptide binding]; other site
357804009122	putative phosphate binding site [ion binding]; other site
357804009123	putative allosteric binding site; other site
357804009124	PUA domain; Region: PUA; pfam01472
357804009125	Transcriptional regulator Crl; Region: Crl; pfam07417
357804009126	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
357804009127	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
357804009128	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
357804009129	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
357804009130	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
357804009131	TrkA-N domain; Region: TrkA_N; pfam02254
357804009132	TrkA-C domain; Region: TrkA_C; pfam02080
357804009133	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
357804009134	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
357804009135	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
357804009136	Walker A/P-loop; other site
357804009137	ATP binding site [chemical binding]; other site
357804009138	Q-loop/lid; other site
357804009139	ABC transporter signature motif; other site
357804009140	Walker B; other site
357804009141	D-loop; other site
357804009142	H-loop/switch region; other site
357804009143	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
357804009144	active site
357804009145	catalytic triad [active]
357804009146	oxyanion hole [active]
357804009147	switch loop; other site
357804009148	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
357804009149	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
357804009150	Ligand Binding Site [chemical binding]; other site
357804009151	TilS substrate binding domain; Region: TilS; pfam09179
357804009152	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
357804009153	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
357804009154	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
357804009155	putative active site [active]
357804009156	putative PHP Thumb interface [polypeptide binding]; other site
357804009157	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
357804009158	generic binding surface II; other site
357804009159	generic binding surface I; other site
357804009160	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
357804009161	RNA/DNA hybrid binding site [nucleotide binding]; other site
357804009162	active site
357804009163	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
357804009164	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
357804009165	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
357804009166	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
357804009167	active site
357804009168	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
357804009169	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
357804009170	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
357804009171	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
357804009172	trimer interface [polypeptide binding]; other site
357804009173	active site
357804009174	UDP-GlcNAc binding site [chemical binding]; other site
357804009175	lipid binding site [chemical binding]; lipid-binding site
357804009176	periplasmic chaperone; Provisional; Region: PRK10780
357804009177	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
357804009178	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
357804009179	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
357804009180	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
357804009181	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
357804009182	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
357804009183	Surface antigen; Region: Bac_surface_Ag; pfam01103
357804009184	zinc metallopeptidase RseP; Provisional; Region: PRK10779
357804009185	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
357804009186	active site
357804009187	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
357804009188	protein binding site [polypeptide binding]; other site
357804009189	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
357804009190	putative substrate binding region [chemical binding]; other site
357804009191	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
357804009192	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
357804009193	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
357804009194	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
357804009195	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
357804009196	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
357804009197	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
357804009198	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
357804009199	catalytic residue [active]
357804009200	putative FPP diphosphate  binding site; other site
357804009201	putative FPP binding hydrophobic cleft; other site
357804009202	dimer interface [polypeptide binding]; other site
357804009203	putative IPP diphosphate binding site; other site
357804009204	ribosome recycling factor; Reviewed; Region: frr; PRK00083
357804009205	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
357804009206	hinge region; other site
357804009207	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
357804009208	putative nucleotide binding site [chemical binding]; other site
357804009209	uridine monophosphate binding site [chemical binding]; other site
357804009210	homohexameric interface [polypeptide binding]; other site
357804009211	elongation factor Ts; Provisional; Region: tsf; PRK09377
357804009212	UBA/TS-N domain; Region: UBA; pfam00627
357804009213	Elongation factor TS; Region: EF_TS; pfam00889
357804009214	Elongation factor TS; Region: EF_TS; pfam00889
357804009215	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
357804009216	rRNA interaction site [nucleotide binding]; other site
357804009217	S8 interaction site; other site
357804009218	putative laminin-1 binding site; other site
357804009219	Protein of unknown function DUF262; Region: DUF262; pfam03235
357804009220	Uncharacterized conserved protein [Function unknown]; Region: COG1479
357804009221	Protein of unknown function DUF262; Region: DUF262; pfam03235
357804009222	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
357804009223	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
357804009224	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
357804009225	Transcriptional regulators [Transcription]; Region: FadR; COG2186
357804009226	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804009227	DNA-binding site [nucleotide binding]; DNA binding site
357804009228	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
357804009229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804009230	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
357804009231	active site
357804009232	phosphorylation site [posttranslational modification]
357804009233	intermolecular recognition site; other site
357804009234	dimerization interface [polypeptide binding]; other site
357804009235	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
357804009236	DNA binding residues [nucleotide binding]
357804009237	dimerization interface [polypeptide binding]; other site
357804009238	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
357804009239	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
357804009240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804009241	dimer interface [polypeptide binding]; other site
357804009242	phosphorylation site [posttranslational modification]
357804009243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804009244	ATP binding site [chemical binding]; other site
357804009245	Mg2+ binding site [ion binding]; other site
357804009246	G-X-G motif; other site
357804009247	Response regulator receiver domain; Region: Response_reg; pfam00072
357804009248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804009249	active site
357804009250	phosphorylation site [posttranslational modification]
357804009251	intermolecular recognition site; other site
357804009252	dimerization interface [polypeptide binding]; other site
357804009253	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
357804009254	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
357804009255	putative ligand binding site [chemical binding]; other site
357804009256	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
357804009257	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
357804009258	TM-ABC transporter signature motif; other site
357804009259	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
357804009260	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
357804009261	TM-ABC transporter signature motif; other site
357804009262	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
357804009263	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
357804009264	Walker A/P-loop; other site
357804009265	ATP binding site [chemical binding]; other site
357804009266	Q-loop/lid; other site
357804009267	ABC transporter signature motif; other site
357804009268	Walker B; other site
357804009269	D-loop; other site
357804009270	H-loop/switch region; other site
357804009271	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
357804009272	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
357804009273	Walker A/P-loop; other site
357804009274	ATP binding site [chemical binding]; other site
357804009275	Q-loop/lid; other site
357804009276	ABC transporter signature motif; other site
357804009277	Walker B; other site
357804009278	D-loop; other site
357804009279	H-loop/switch region; other site
357804009280	UreD urease accessory protein; Region: UreD; pfam01774
357804009281	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
357804009282	alpha-gamma subunit interface [polypeptide binding]; other site
357804009283	beta-gamma subunit interface [polypeptide binding]; other site
357804009284	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
357804009285	gamma-beta subunit interface [polypeptide binding]; other site
357804009286	alpha-beta subunit interface [polypeptide binding]; other site
357804009287	urease subunit alpha; Reviewed; Region: ureC; PRK13207
357804009288	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
357804009289	subunit interactions [polypeptide binding]; other site
357804009290	active site
357804009291	flap region; other site
357804009292	urease accessory protein UreE; Provisional; Region: PRK14113
357804009293	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
357804009294	dimer interface [polypeptide binding]; other site
357804009295	catalytic residues [active]
357804009296	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
357804009297	UreF; Region: UreF; pfam01730
357804009298	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
357804009299	Transposase IS200 like; Region: Y1_Tnp; pfam01797
357804009300	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
357804009301	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
357804009302	Zn2+ binding site [ion binding]; other site
357804009303	Mg2+ binding site [ion binding]; other site
357804009304	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
357804009305	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
357804009306	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
357804009307	shikimate binding site; other site
357804009308	NAD(P) binding site [chemical binding]; other site
357804009309	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
357804009310	active site
357804009311	PII uridylyl-transferase; Provisional; Region: PRK05007
357804009312	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
357804009313	metal binding triad; other site
357804009314	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
357804009315	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
357804009316	Zn2+ binding site [ion binding]; other site
357804009317	Mg2+ binding site [ion binding]; other site
357804009318	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
357804009319	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
357804009320	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
357804009321	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
357804009322	Walker A/P-loop; other site
357804009323	ATP binding site [chemical binding]; other site
357804009324	Q-loop/lid; other site
357804009325	ABC transporter signature motif; other site
357804009326	Walker B; other site
357804009327	D-loop; other site
357804009328	H-loop/switch region; other site
357804009329	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
357804009330	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804009331	dimer interface [polypeptide binding]; other site
357804009332	conserved gate region; other site
357804009333	putative PBP binding loops; other site
357804009334	ABC-ATPase subunit interface; other site
357804009335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804009336	dimer interface [polypeptide binding]; other site
357804009337	conserved gate region; other site
357804009338	putative PBP binding loops; other site
357804009339	ABC-ATPase subunit interface; other site
357804009340	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
357804009341	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
357804009342	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
357804009343	putative active site [active]
357804009344	putative catalytic site [active]
357804009345	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
357804009346	active site
357804009347	dimer interface [polypeptide binding]; other site
357804009348	tetratricopeptide repeat protein; Provisional; Region: PRK11788
357804009349	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804009350	binding surface
357804009351	TPR motif; other site
357804009352	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
357804009353	TPR motif; other site
357804009354	binding surface
357804009355	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
357804009356	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
357804009357	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
357804009358	IHF dimer interface [polypeptide binding]; other site
357804009359	IHF - DNA interface [nucleotide binding]; other site
357804009360	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
357804009361	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
357804009362	RNA binding site [nucleotide binding]; other site
357804009363	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
357804009364	RNA binding site [nucleotide binding]; other site
357804009365	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
357804009366	RNA binding site [nucleotide binding]; other site
357804009367	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
357804009368	RNA binding site [nucleotide binding]; other site
357804009369	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
357804009370	RNA binding site [nucleotide binding]; other site
357804009371	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
357804009372	RNA binding site [nucleotide binding]; other site
357804009373	cytidylate kinase; Provisional; Region: cmk; PRK00023
357804009374	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
357804009375	CMP-binding site; other site
357804009376	The sites determining sugar specificity; other site
357804009377	VacJ like lipoprotein; Region: VacJ; cl01073
357804009378	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
357804009379	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
357804009380	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
357804009381	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
357804009382	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
357804009383	catalytic residues [active]
357804009384	central insert; other site
357804009385	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
357804009386	CcmE; Region: CcmE; cl00994
357804009387	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
357804009388	heme exporter protein CcmC; Region: ccmC; TIGR01191
357804009389	heme exporter protein CcmB; Region: ccmB; TIGR01190
357804009390	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
357804009391	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
357804009392	Walker A/P-loop; other site
357804009393	ATP binding site [chemical binding]; other site
357804009394	Q-loop/lid; other site
357804009395	ABC transporter signature motif; other site
357804009396	Walker B; other site
357804009397	D-loop; other site
357804009398	H-loop/switch region; other site
357804009399	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
357804009400	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
357804009401	Nitrogen regulatory protein P-II; Region: P-II; smart00938
357804009402	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
357804009403	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
357804009404	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
357804009405	hypothetical protein; Provisional; Region: PRK04998
357804009406	lipoate-protein ligase B; Provisional; Region: PRK14342
357804009407	lipoyl synthase; Provisional; Region: PRK05481
357804009408	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804009409	FeS/SAM binding site; other site
357804009410	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
357804009411	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
357804009412	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
357804009413	catalytic residue [active]
357804009414	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
357804009415	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
357804009416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804009417	S-adenosylmethionine binding site [chemical binding]; other site
357804009418	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
357804009419	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
357804009420	ligand binding site; other site
357804009421	oligomer interface; other site
357804009422	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
357804009423	N-terminal domain interface [polypeptide binding]; other site
357804009424	sulfate 1 binding site; other site
357804009425	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
357804009426	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
357804009427	ligand binding site; other site
357804009428	oligomer interface; other site
357804009429	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
357804009430	dimer interface [polypeptide binding]; other site
357804009431	N-terminal domain interface [polypeptide binding]; other site
357804009432	sulfate 1 binding site; other site
357804009433	glycogen synthase; Provisional; Region: glgA; PRK00654
357804009434	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
357804009435	ADP-binding pocket [chemical binding]; other site
357804009436	homodimer interface [polypeptide binding]; other site
357804009437	helicase 45; Provisional; Region: PTZ00424
357804009438	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
357804009439	ATP binding site [chemical binding]; other site
357804009440	Mg++ binding site [ion binding]; other site
357804009441	motif III; other site
357804009442	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804009443	nucleotide binding region [chemical binding]; other site
357804009444	ATP-binding site [chemical binding]; other site
357804009445	hypothetical protein; Validated; Region: PRK02101
357804009446	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
357804009447	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
357804009448	Walker A motif; other site
357804009449	ATP binding site [chemical binding]; other site
357804009450	Walker B motif; other site
357804009451	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
357804009452	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
357804009453	Walker A motif; other site
357804009454	ATP binding site [chemical binding]; other site
357804009455	Walker B motif; other site
357804009456	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
357804009457	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
357804009458	catalytic residue [active]
357804009459	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
357804009460	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
357804009461	YGGT family; Region: YGGT; pfam02325
357804009462	YGGT family; Region: YGGT; pfam02325
357804009463	hypothetical protein; Validated; Region: PRK05090
357804009464	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
357804009465	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
357804009466	active site
357804009467	dimerization interface [polypeptide binding]; other site
357804009468	HemN family oxidoreductase; Provisional; Region: PRK05660
357804009469	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804009470	FeS/SAM binding site; other site
357804009471	HemN C-terminal domain; Region: HemN_C; pfam06969
357804009472	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
357804009473	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
357804009474	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
357804009475	TrkA-N domain; Region: TrkA_N; pfam02254
357804009476	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
357804009477	Mechanosensitive ion channel; Region: MS_channel; pfam00924
357804009478	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
357804009479	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
357804009480	Metal-binding active site; metal-binding site
357804009481	putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273
357804009482	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
357804009483	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
357804009484	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
357804009485	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
357804009486	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
357804009487	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
357804009488	Probable transposase; Region: OrfB_IS605; pfam01385
357804009489	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
357804009490	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
357804009491	putative fimbrial protein TcfA; Provisional; Region: PRK15308
357804009492	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
357804009493	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
357804009494	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
357804009495	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
357804009496	active site
357804009497	catalytic site [active]
357804009498	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
357804009499	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
357804009500	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
357804009501	putative acyl-acceptor binding pocket; other site
357804009502	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
357804009503	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
357804009504	heme-binding site [chemical binding]; other site
357804009505	CHASE3 domain; Region: CHASE3; pfam05227
357804009506	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804009507	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804009508	metal binding site [ion binding]; metal-binding site
357804009509	active site
357804009510	I-site; other site
357804009511	Transthyretin-like family; Region: DUF290; pfam01060
357804009512	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
357804009513	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
357804009514	active site
357804009515	dinuclear metal binding site [ion binding]; other site
357804009516	dimerization interface [polypeptide binding]; other site
357804009517	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804009518	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804009519	metal binding site [ion binding]; metal-binding site
357804009520	active site
357804009521	I-site; other site
357804009522	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
357804009523	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
357804009524	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
357804009525	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
357804009526	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
357804009527	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
357804009528	Trp docking motif [polypeptide binding]; other site
357804009529	putative active site [active]
357804009530	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
357804009531	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
357804009532	FMN binding site [chemical binding]; other site
357804009533	active site
357804009534	substrate binding site [chemical binding]; other site
357804009535	catalytic residue [active]
357804009536	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
357804009537	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
357804009538	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804009539	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804009540	metal binding site [ion binding]; metal-binding site
357804009541	active site
357804009542	I-site; other site
357804009543	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804009544	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
357804009545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804009546	putative substrate translocation pore; other site
357804009547	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804009548	Sensors of blue-light using FAD; Region: BLUF; smart01034
357804009549	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804009550	DNA-binding site [nucleotide binding]; DNA binding site
357804009551	RNA-binding motif; other site
357804009552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804009553	Major Facilitator Superfamily; Region: MFS_1; pfam07690
357804009554	putative substrate translocation pore; other site
357804009555	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804009556	DNA-binding site [nucleotide binding]; DNA binding site
357804009557	RNA-binding motif; other site
357804009558	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
357804009559	AAA ATPase domain; Region: AAA_16; pfam13191
357804009560	Tetratricopeptide repeat; Region: TPR_12; pfam13424
357804009561	Tetratricopeptide repeat; Region: TPR_10; pfam13374
357804009562	TniQ; Region: TniQ; pfam06527
357804009563	AAA domain; Region: AAA_22; pfam13401
357804009564	Bacterial TniB protein; Region: TniB; pfam05621
357804009565	Integrase core domain; Region: rve; pfam00665
357804009566	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
357804009567	HNH endonuclease; Region: HNH_5; pfam14279
357804009568	DEAD-like helicases superfamily; Region: DEXDc; smart00487
357804009569	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804009570	ATP binding site [chemical binding]; other site
357804009571	putative Mg++ binding site [ion binding]; other site
357804009572	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
357804009573	nucleotide binding region [chemical binding]; other site
357804009574	ATP-binding site [chemical binding]; other site
357804009575	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
357804009576	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
357804009577	Predicted flavoproteins [General function prediction only]; Region: COG2081
357804009578	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
357804009579	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
357804009580	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
357804009581	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
357804009582	SlyX; Region: SlyX; pfam04102
357804009583	PilX N-terminal; Region: PilX_N; pfam14341
357804009584	acetyl-CoA synthetase; Provisional; Region: PRK00174
357804009585	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
357804009586	active site
357804009587	CoA binding site [chemical binding]; other site
357804009588	acyl-activating enzyme (AAE) consensus motif; other site
357804009589	AMP binding site [chemical binding]; other site
357804009590	acetate binding site [chemical binding]; other site
357804009591	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
357804009592	Dehydroquinase class II; Region: DHquinase_II; pfam01220
357804009593	active site
357804009594	trimer interface [polypeptide binding]; other site
357804009595	dimer interface [polypeptide binding]; other site
357804009596	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
357804009597	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
357804009598	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
357804009599	FMN binding site [chemical binding]; other site
357804009600	active site
357804009601	catalytic residues [active]
357804009602	substrate binding site [chemical binding]; other site
357804009603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804009604	Walker A motif; other site
357804009605	ATP binding site [chemical binding]; other site
357804009606	Walker B motif; other site
357804009607	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
357804009608	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
357804009609	Transposase; Region: DEDD_Tnp_IS110; pfam01548
357804009610	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
357804009611	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
357804009612	CheB methylesterase; Region: CheB_methylest; pfam01339
357804009613	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
357804009614	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
357804009615	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
357804009616	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
357804009617	PAS domain; Region: PAS_10; pfam13596
357804009618	PAS domain S-box; Region: sensory_box; TIGR00229
357804009619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804009620	PAS domain; Region: PAS_9; pfam13426
357804009621	putative active site [active]
357804009622	heme pocket [chemical binding]; other site
357804009623	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804009624	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804009625	metal binding site [ion binding]; metal-binding site
357804009626	active site
357804009627	I-site; other site
357804009628	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804009629	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
357804009630	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
357804009631	catalytic loop [active]
357804009632	iron binding site [ion binding]; other site
357804009633	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
357804009634	methionine sulfoxide reductase A; Provisional; Region: PRK05528
357804009635	Protein of unknown function, DUF462; Region: DUF462; pfam04315
357804009636	YfcL protein; Region: YfcL; pfam08891
357804009637	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804009638	PAS domain; Region: PAS_9; pfam13426
357804009639	putative active site [active]
357804009640	heme pocket [chemical binding]; other site
357804009641	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804009642	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804009643	metal binding site [ion binding]; metal-binding site
357804009644	active site
357804009645	I-site; other site
357804009646	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804009647	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
357804009648	Lumazine binding domain; Region: Lum_binding; pfam00677
357804009649	Lumazine binding domain; Region: Lum_binding; pfam00677
357804009650	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_12; cd04670
357804009651	nudix motif; other site
357804009652	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
357804009653	DctM-like transporters; Region: DctM; pfam06808
357804009654	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
357804009655	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
357804009656	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
357804009657	Membrane transport protein; Region: Mem_trans; cl09117
357804009658	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
357804009659	short chain dehydrogenase; Provisional; Region: PRK05993
357804009660	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
357804009661	NADP binding site [chemical binding]; other site
357804009662	active site
357804009663	steroid binding site; other site
357804009664	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
357804009665	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
357804009666	catalytic residues [active]
357804009667	hinge region; other site
357804009668	alpha helical domain; other site
357804009669	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
357804009670	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804009671	Walker A/P-loop; other site
357804009672	ATP binding site [chemical binding]; other site
357804009673	Q-loop/lid; other site
357804009674	ABC transporter signature motif; other site
357804009675	Walker B; other site
357804009676	D-loop; other site
357804009677	H-loop/switch region; other site
357804009678	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804009679	Walker A/P-loop; other site
357804009680	ATP binding site [chemical binding]; other site
357804009681	Q-loop/lid; other site
357804009682	ABC transporter signature motif; other site
357804009683	Walker B; other site
357804009684	D-loop; other site
357804009685	H-loop/switch region; other site
357804009686	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
357804009687	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
357804009688	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
357804009689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804009690	dimer interface [polypeptide binding]; other site
357804009691	conserved gate region; other site
357804009692	putative PBP binding loops; other site
357804009693	ABC-ATPase subunit interface; other site
357804009694	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
357804009695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
357804009696	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
357804009697	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
357804009698	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
357804009699	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
357804009700	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
357804009701	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
357804009702	DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625
357804009703	putative ligand binding site [chemical binding]; other site
357804009704	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
357804009705	Asn-Pro-Ala signature motifs; other site
357804009706	glycerol kinase; Provisional; Region: glpK; PRK00047
357804009707	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
357804009708	N- and C-terminal domain interface [polypeptide binding]; other site
357804009709	active site
357804009710	MgATP binding site [chemical binding]; other site
357804009711	catalytic site [active]
357804009712	metal binding site [ion binding]; metal-binding site
357804009713	glycerol binding site [chemical binding]; other site
357804009714	homotetramer interface [polypeptide binding]; other site
357804009715	homodimer interface [polypeptide binding]; other site
357804009716	FBP binding site [chemical binding]; other site
357804009717	protein IIAGlc interface [polypeptide binding]; other site
357804009718	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
357804009719	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
357804009720	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
357804009721	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
357804009722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804009723	dimer interface [polypeptide binding]; other site
357804009724	conserved gate region; other site
357804009725	putative PBP binding loops; other site
357804009726	ABC-ATPase subunit interface; other site
357804009727	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
357804009728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804009729	putative PBP binding loops; other site
357804009730	dimer interface [polypeptide binding]; other site
357804009731	ABC-ATPase subunit interface; other site
357804009732	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
357804009733	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
357804009734	Walker A/P-loop; other site
357804009735	ATP binding site [chemical binding]; other site
357804009736	Q-loop/lid; other site
357804009737	ABC transporter signature motif; other site
357804009738	Walker B; other site
357804009739	D-loop; other site
357804009740	H-loop/switch region; other site
357804009741	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
357804009742	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
357804009743	Walker A/P-loop; other site
357804009744	ATP binding site [chemical binding]; other site
357804009745	Q-loop/lid; other site
357804009746	ABC transporter signature motif; other site
357804009747	Walker B; other site
357804009748	D-loop; other site
357804009749	H-loop/switch region; other site
357804009750	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
357804009751	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
357804009752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804009753	Walker A motif; other site
357804009754	ATP binding site [chemical binding]; other site
357804009755	Walker B motif; other site
357804009756	arginine finger; other site
357804009757	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
357804009758	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
357804009759	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
357804009760	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
357804009761	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
357804009762	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
357804009763	active site
357804009764	catalytic site [active]
357804009765	metal binding site [ion binding]; metal-binding site
357804009766	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
357804009767	active site
357804009768	metal binding site [ion binding]; metal-binding site
357804009769	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
357804009770	metal binding site 2 [ion binding]; metal-binding site
357804009771	putative DNA binding helix; other site
357804009772	metal binding site 1 [ion binding]; metal-binding site
357804009773	dimer interface [polypeptide binding]; other site
357804009774	structural Zn2+ binding site [ion binding]; other site
357804009775	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
357804009776	active site
357804009777	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
357804009778	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
357804009779	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804009780	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
357804009781	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804009782	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
357804009783	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
357804009784	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804009785	Outer membrane efflux protein; Region: OEP; pfam02321
357804009786	Outer membrane efflux protein; Region: OEP; pfam02321
357804009787	DNA polymerase I; Provisional; Region: PRK05755
357804009788	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
357804009789	active site
357804009790	metal binding site 1 [ion binding]; metal-binding site
357804009791	putative 5' ssDNA interaction site; other site
357804009792	metal binding site 3; metal-binding site
357804009793	metal binding site 2 [ion binding]; metal-binding site
357804009794	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
357804009795	putative DNA binding site [nucleotide binding]; other site
357804009796	putative metal binding site [ion binding]; other site
357804009797	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
357804009798	active site
357804009799	catalytic site [active]
357804009800	substrate binding site [chemical binding]; other site
357804009801	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
357804009802	active site
357804009803	DNA binding site [nucleotide binding]
357804009804	catalytic site [active]
357804009805	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
357804009806	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
357804009807	putative acyl-acceptor binding pocket; other site
357804009808	FMN reductase; Validated; Region: fre; PRK08051
357804009809	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
357804009810	FAD binding pocket [chemical binding]; other site
357804009811	FAD binding motif [chemical binding]; other site
357804009812	phosphate binding motif [ion binding]; other site
357804009813	beta-alpha-beta structure motif; other site
357804009814	NAD binding pocket [chemical binding]; other site
357804009815	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
357804009816	transcription termination factor Rho; Provisional; Region: rho; PRK09376
357804009817	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
357804009818	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
357804009819	RNA binding site [nucleotide binding]; other site
357804009820	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
357804009821	multimer interface [polypeptide binding]; other site
357804009822	Walker A motif; other site
357804009823	ATP binding site [chemical binding]; other site
357804009824	Walker B motif; other site
357804009825	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
357804009826	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
357804009827	catalytic residues [active]
357804009828	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
357804009829	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
357804009830	ATP binding site [chemical binding]; other site
357804009831	Mg++ binding site [ion binding]; other site
357804009832	motif III; other site
357804009833	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804009834	nucleotide binding region [chemical binding]; other site
357804009835	ATP-binding site [chemical binding]; other site
357804009836	exopolyphosphatase; Region: exo_poly_only; TIGR03706
357804009837	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
357804009838	Homeodomain-like domain; Region: HTH_23; pfam13384
357804009839	Winged helix-turn helix; Region: HTH_29; pfam13551
357804009840	Homeodomain-like domain; Region: HTH_32; pfam13565
357804009841	Winged helix-turn helix; Region: HTH_33; pfam13592
357804009842	DDE superfamily endonuclease; Region: DDE_3; pfam13358
357804009843	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
357804009844	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
357804009845	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
357804009846	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804009847	Walker A/P-loop; other site
357804009848	ATP binding site [chemical binding]; other site
357804009849	Q-loop/lid; other site
357804009850	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804009851	ABC transporter; Region: ABC_tran_2; pfam12848
357804009852	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804009853	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
357804009854	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
357804009855	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
357804009856	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
357804009857	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
357804009858	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
357804009859	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
357804009860	active site
357804009861	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
357804009862	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
357804009863	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
357804009864	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
357804009865	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
357804009866	ATP binding site [chemical binding]; other site
357804009867	Mg++ binding site [ion binding]; other site
357804009868	motif III; other site
357804009869	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804009870	nucleotide binding region [chemical binding]; other site
357804009871	ATP-binding site [chemical binding]; other site
357804009872	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
357804009873	putative RNA binding site [nucleotide binding]; other site
357804009874	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
357804009875	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
357804009876	Substrate binding site; other site
357804009877	Mg++ binding site; other site
357804009878	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
357804009879	active site
357804009880	substrate binding site [chemical binding]; other site
357804009881	CoA binding site [chemical binding]; other site
357804009882	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
357804009883	NAD synthase; Region: NAD_synthase; pfam02540
357804009884	NAD binding pocket [chemical binding]; other site
357804009885	ATP binding pocket [chemical binding]; other site
357804009886	Mg binding site [ion binding]; other site
357804009887	active-site loop [active]
357804009888	homodimer interface [polypeptide binding]; other site
357804009889	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
357804009890	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
357804009891	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
357804009892	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
357804009893	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
357804009894	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
357804009895	SecA binding site; other site
357804009896	Preprotein binding site; other site
357804009897	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
357804009898	GSH binding site [chemical binding]; other site
357804009899	catalytic residues [active]
357804009900	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
357804009901	active site residue [active]
357804009902	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
357804009903	phosphoglyceromutase; Provisional; Region: PRK05434
357804009904	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
357804009905	Peptidase family M23; Region: Peptidase_M23; pfam01551
357804009906	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
357804009907	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
357804009908	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804009909	S-adenosylmethionine binding site [chemical binding]; other site
357804009910	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
357804009911	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
357804009912	FMN binding site [chemical binding]; other site
357804009913	active site
357804009914	catalytic residues [active]
357804009915	substrate binding site [chemical binding]; other site
357804009916	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
357804009917	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
357804009918	Protein of unknown function (DUF416); Region: DUF416; pfam04222
357804009919	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
357804009920	IHF dimer interface [polypeptide binding]; other site
357804009921	IHF - DNA interface [nucleotide binding]; other site
357804009922	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
357804009923	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
357804009924	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
357804009925	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
357804009926	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
357804009927	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
357804009928	purine monophosphate binding site [chemical binding]; other site
357804009929	dimer interface [polypeptide binding]; other site
357804009930	putative catalytic residues [active]
357804009931	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
357804009932	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
357804009933	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
357804009934	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
357804009935	substrate binding site [chemical binding]; other site
357804009936	active site
357804009937	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
357804009938	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
357804009939	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
357804009940	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
357804009941	putative NADH binding site [chemical binding]; other site
357804009942	putative active site [active]
357804009943	nudix motif; other site
357804009944	putative metal binding site [ion binding]; other site
357804009945	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; pfam04353
357804009946	putative peptidase; Provisional; Region: PRK11649
357804009947	Peptidase family M23; Region: Peptidase_M23; pfam01551
357804009948	S-adenosylmethionine synthetase; Validated; Region: PRK05250
357804009949	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
357804009950	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
357804009951	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
357804009952	hypothetical protein; Provisional; Region: PRK04860
357804009953	SprT homologues; Region: SprT; cl01182
357804009954	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
357804009955	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
357804009956	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
357804009957	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804009958	Coenzyme A binding pocket [chemical binding]; other site
357804009959	DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436
357804009960	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
357804009961	trehalose repressor; Provisional; Region: treR; PRK09492
357804009962	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804009963	DNA binding site [nucleotide binding]
357804009964	domain linker motif; other site
357804009965	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
357804009966	dimerization interface [polypeptide binding]; other site
357804009967	ligand binding site [chemical binding]; other site
357804009968	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
357804009969	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
357804009970	GDP-binding site [chemical binding]; other site
357804009971	ACT binding site; other site
357804009972	IMP binding site; other site
357804009973	FtsH protease regulator HflC; Provisional; Region: PRK11029
357804009974	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
357804009975	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
357804009976	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
357804009977	HflK protein; Region: hflK; TIGR01933
357804009978	GTPase HflX; Provisional; Region: PRK11058
357804009979	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
357804009980	HflX GTPase family; Region: HflX; cd01878
357804009981	G1 box; other site
357804009982	GTP/Mg2+ binding site [chemical binding]; other site
357804009983	Switch I region; other site
357804009984	G2 box; other site
357804009985	G3 box; other site
357804009986	Switch II region; other site
357804009987	G4 box; other site
357804009988	G5 box; other site
357804009989	bacterial Hfq-like; Region: Hfq; cd01716
357804009990	hexamer interface [polypeptide binding]; other site
357804009991	Sm1 motif; other site
357804009992	RNA binding site [nucleotide binding]; other site
357804009993	Sm2 motif; other site
357804009994	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
357804009995	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
357804009996	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
357804009997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804009998	ATP binding site [chemical binding]; other site
357804009999	Mg2+ binding site [ion binding]; other site
357804010000	G-X-G motif; other site
357804010001	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
357804010002	ATP binding site [chemical binding]; other site
357804010003	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
357804010004	AMIN domain; Region: AMIN; pfam11741
357804010005	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
357804010006	active site
357804010007	metal binding site [ion binding]; metal-binding site
357804010008	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804010009	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804010010	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
357804010011	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804010012	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804010013	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804010014	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804010015	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
357804010016	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804010017	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
357804010018	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
357804010019	putative carbohydrate kinase; Provisional; Region: PRK10565
357804010020	Uncharacterized conserved protein [Function unknown]; Region: COG0062
357804010021	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
357804010022	putative substrate binding site [chemical binding]; other site
357804010023	putative ATP binding site [chemical binding]; other site
357804010024	epoxyqueuosine reductase; Region: TIGR00276
357804010025	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
357804010026	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
357804010027	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
357804010028	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804010029	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
357804010030	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
357804010031	dimerization interface [polypeptide binding]; other site
357804010032	PilX N-terminal; Region: PilX_N; pfam14341
357804010033	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
357804010034	PilX N-terminal; Region: PilX_N; pfam14341
357804010035	PilX N-terminal; Region: PilX_N; pfam14341
357804010036	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
357804010037	PilX N-terminal; Region: PilX_N; pfam14341
357804010038	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
357804010039	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
357804010040	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
357804010041	Type II transport protein GspH; Region: GspH; pfam12019
357804010042	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
357804010043	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
357804010044	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
357804010045	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
357804010046	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
357804010047	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
357804010048	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
357804010049	Uncharacterized conserved protein [Function unknown]; Region: COG1432
357804010050	LabA_like proteins; Region: LabA; cd10911
357804010051	putative metal binding site [ion binding]; other site
357804010052	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
357804010053	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
357804010054	ATP binding site [chemical binding]; other site
357804010055	Mg++ binding site [ion binding]; other site
357804010056	motif III; other site
357804010057	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804010058	nucleotide binding region [chemical binding]; other site
357804010059	ATP-binding site [chemical binding]; other site
357804010060	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
357804010061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804010062	Walker A/P-loop; other site
357804010063	ATP binding site [chemical binding]; other site
357804010064	Q-loop/lid; other site
357804010065	ABC transporter signature motif; other site
357804010066	Walker B; other site
357804010067	D-loop; other site
357804010068	H-loop/switch region; other site
357804010069	ABC transporter; Region: ABC_tran_2; pfam12848
357804010070	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
357804010071	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
357804010072	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
357804010073	active site
357804010074	catalytic tetrad [active]
357804010075	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
357804010076	Clp amino terminal domain; Region: Clp_N; pfam02861
357804010077	Clp amino terminal domain; Region: Clp_N; pfam02861
357804010078	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804010079	Walker A motif; other site
357804010080	ATP binding site [chemical binding]; other site
357804010081	Walker B motif; other site
357804010082	arginine finger; other site
357804010083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804010084	Walker A motif; other site
357804010085	ATP binding site [chemical binding]; other site
357804010086	Walker B motif; other site
357804010087	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
357804010088	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
357804010089	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
357804010090	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
357804010091	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
357804010092	RNA binding surface [nucleotide binding]; other site
357804010093	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
357804010094	active site
357804010095	Outer membrane lipoprotein; Region: YfiO; pfam13525
357804010096	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
357804010097	Nitrogen regulatory protein P-II; Region: P-II; smart00938
357804010098	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
357804010099	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
357804010100	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
357804010101	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
357804010102	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
357804010103	lipoprotein signal peptidase; Provisional; Region: PRK14787
357804010104	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
357804010105	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
357804010106	active site
357804010107	HIGH motif; other site
357804010108	nucleotide binding site [chemical binding]; other site
357804010109	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
357804010110	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
357804010111	active site
357804010112	KMSKS motif; other site
357804010113	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
357804010114	tRNA binding surface [nucleotide binding]; other site
357804010115	anticodon binding site; other site
357804010116	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
357804010117	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
357804010118	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
357804010119	active site
357804010120	Riboflavin kinase; Region: Flavokinase; smart00904
357804010121	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
357804010122	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
357804010123	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
357804010124	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
357804010125	poxB regulator PoxA; Provisional; Region: PRK09350
357804010126	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
357804010127	motif 1; other site
357804010128	dimer interface [polypeptide binding]; other site
357804010129	active site
357804010130	motif 2; other site
357804010131	motif 3; other site
357804010132	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
357804010133	L-aspartate oxidase; Provisional; Region: PRK06175
357804010134	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
357804010135	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
357804010136	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
357804010137	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
357804010138	D-subunit interface [polypeptide binding]; other site
357804010139	Iron-sulfur protein interface; other site
357804010140	proximal quinone binding site [chemical binding]; other site
357804010141	distal quinone binding site [chemical binding]; other site
357804010142	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
357804010143	Iron-sulfur protein interface; other site
357804010144	proximal quinone binding site [chemical binding]; other site
357804010145	C-subunit interface; other site
357804010146	distal quinone binding site; other site
357804010147	elongation factor P; Validated; Region: PRK00529
357804010148	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
357804010149	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
357804010150	RNA binding site [nucleotide binding]; other site
357804010151	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
357804010152	RNA binding site [nucleotide binding]; other site
357804010153	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
357804010154	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804010155	FeS/SAM binding site; other site
357804010156	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
357804010157	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804010158	active site
357804010159	motif I; other site
357804010160	motif II; other site
357804010161	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
357804010162	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
357804010163	homodimer interaction site [polypeptide binding]; other site
357804010164	cofactor binding site; other site
357804010165	Rhomboid family; Region: Rhomboid; pfam01694
357804010166	prolyl-tRNA synthetase; Provisional; Region: PRK09194
357804010167	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
357804010168	dimer interface [polypeptide binding]; other site
357804010169	motif 1; other site
357804010170	active site
357804010171	motif 2; other site
357804010172	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
357804010173	putative deacylase active site [active]
357804010174	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
357804010175	active site
357804010176	motif 3; other site
357804010177	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
357804010178	anticodon binding site; other site
357804010179	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
357804010180	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
357804010181	PGAP1-like protein; Region: PGAP1; pfam07819
357804010182	putative hydrolase; Provisional; Region: PRK10976
357804010183	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804010184	active site
357804010185	motif I; other site
357804010186	motif II; other site
357804010187	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
357804010188	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
357804010189	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
357804010190	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
357804010191	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
357804010192	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
357804010193	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
357804010194	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
357804010195	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
357804010196	Protein of unknown function (DUF904); Region: DUF904; pfam06005
357804010197	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
357804010198	serine acetyltransferase; Provisional; Region: cysE; PRK11132
357804010199	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
357804010200	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
357804010201	trimer interface [polypeptide binding]; other site
357804010202	active site
357804010203	substrate binding site [chemical binding]; other site
357804010204	CoA binding site [chemical binding]; other site
357804010205	Cation efflux family; Region: Cation_efflux; cl00316
357804010206	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
357804010207	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
357804010208	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
357804010209	DHH family; Region: DHH; pfam01368
357804010210	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
357804010211	active site
357804010212	DHHA1 domain; Region: DHHA1; pfam02272
357804010213	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
357804010214	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
357804010215	dimerization domain [polypeptide binding]; other site
357804010216	dimer interface [polypeptide binding]; other site
357804010217	catalytic residues [active]
357804010218	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
357804010219	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
357804010220	active site
357804010221	Int/Topo IB signature motif; other site
357804010222	flavodoxin FldB; Provisional; Region: PRK12359
357804010223	formate transporter FocA; Region: formate_focA; TIGR04060
357804010224	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
357804010225	Pyruvate formate lyase 1; Region: PFL1; cd01678
357804010226	coenzyme A binding site [chemical binding]; other site
357804010227	active site
357804010228	catalytic residues [active]
357804010229	glycine loop; other site
357804010230	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
357804010231	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
357804010232	FeS/SAM binding site; other site
357804010233	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
357804010234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804010235	S-adenosylmethionine binding site [chemical binding]; other site
357804010236	Protein of unknown function, DUF412; Region: DUF412; pfam04217
357804010237	propionate/acetate kinase; Provisional; Region: PRK12379
357804010238	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
357804010239	phosphate acetyltransferase; Reviewed; Region: PRK05632
357804010240	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
357804010241	DRTGG domain; Region: DRTGG; pfam07085
357804010242	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
357804010243	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
357804010244	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804010245	S-adenosylmethionine binding site [chemical binding]; other site
357804010246	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
357804010247	Domain of unknown function DUF20; Region: UPF0118; pfam01594
357804010248	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
357804010249	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
357804010250	putative catalytic cysteine [active]
357804010251	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
357804010252	putative active site [active]
357804010253	metal binding site [ion binding]; metal-binding site
357804010254	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
357804010255	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
357804010256	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
357804010257	putative active site [active]
357804010258	catalytic site [active]
357804010259	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
357804010260	putative active site [active]
357804010261	catalytic site [active]
357804010262	PAS domain; Region: PAS; smart00091
357804010263	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804010264	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804010265	putative active site [active]
357804010266	heme pocket [chemical binding]; other site
357804010267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804010268	PAS domain; Region: PAS_9; pfam13426
357804010269	putative active site [active]
357804010270	heme pocket [chemical binding]; other site
357804010271	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804010272	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804010273	metal binding site [ion binding]; metal-binding site
357804010274	active site
357804010275	I-site; other site
357804010276	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804010277	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
357804010278	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
357804010279	dimerization interface [polypeptide binding]; other site
357804010280	ATP binding site [chemical binding]; other site
357804010281	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
357804010282	dimerization interface [polypeptide binding]; other site
357804010283	ATP binding site [chemical binding]; other site
357804010284	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
357804010285	putative active site [active]
357804010286	catalytic triad [active]
357804010287	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
357804010288	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
357804010289	substrate binding pocket [chemical binding]; other site
357804010290	membrane-bound complex binding site; other site
357804010291	hinge residues; other site
357804010292	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
357804010293	N-acetyl-D-glucosamine binding site [chemical binding]; other site
357804010294	catalytic residue [active]
357804010295	HEAT repeats; Region: HEAT_2; pfam13646
357804010296	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
357804010297	active site
357804010298	catalytic residues [active]
357804010299	metal binding site [ion binding]; metal-binding site
357804010300	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
357804010301	nucleoside/Zn binding site; other site
357804010302	dimer interface [polypeptide binding]; other site
357804010303	catalytic motif [active]
357804010304	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
357804010305	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
357804010306	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
357804010307	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
357804010308	active site
357804010309	multimer interface [polypeptide binding]; other site
357804010310	hypothetical protein; Provisional; Region: PRK05421
357804010311	putative catalytic site [active]
357804010312	putative phosphate binding site [ion binding]; other site
357804010313	putative metal binding site [ion binding]; other site
357804010314	Response regulator receiver domain; Region: Response_reg; pfam00072
357804010315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804010316	active site
357804010317	phosphorylation site [posttranslational modification]
357804010318	intermolecular recognition site; other site
357804010319	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
357804010320	dimerization interface [polypeptide binding]; other site
357804010321	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804010322	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804010323	metal binding site [ion binding]; metal-binding site
357804010324	active site
357804010325	I-site; other site
357804010326	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804010327	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
357804010328	Cache domain; Region: Cache_1; pfam02743
357804010329	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
357804010330	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804010331	dimer interface [polypeptide binding]; other site
357804010332	phosphorylation site [posttranslational modification]
357804010333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804010334	ATP binding site [chemical binding]; other site
357804010335	Mg2+ binding site [ion binding]; other site
357804010336	G-X-G motif; other site
357804010337	Response regulator receiver domain; Region: Response_reg; pfam00072
357804010338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804010339	active site
357804010340	phosphorylation site [posttranslational modification]
357804010341	intermolecular recognition site; other site
357804010342	dimerization interface [polypeptide binding]; other site
357804010343	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
357804010344	putative binding surface; other site
357804010345	active site
357804010346	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
357804010347	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
357804010348	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
357804010349	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804010350	Major Facilitator Superfamily; Region: MFS_1; pfam07690
357804010351	putative substrate translocation pore; other site
357804010352	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
357804010353	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
357804010354	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
357804010355	catalytic site [active]
357804010356	putative active site [active]
357804010357	putative substrate binding site [chemical binding]; other site
357804010358	dimer interface [polypeptide binding]; other site
357804010359	GTPase RsgA; Reviewed; Region: PRK12288
357804010360	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
357804010361	RNA binding site [nucleotide binding]; other site
357804010362	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
357804010363	GTPase/Zn-binding domain interface [polypeptide binding]; other site
357804010364	GTP/Mg2+ binding site [chemical binding]; other site
357804010365	G4 box; other site
357804010366	G5 box; other site
357804010367	G1 box; other site
357804010368	Switch I region; other site
357804010369	G2 box; other site
357804010370	G3 box; other site
357804010371	Switch II region; other site
357804010372	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
357804010373	threonine dehydratase; Reviewed; Region: PRK09224
357804010374	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
357804010375	tetramer interface [polypeptide binding]; other site
357804010376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804010377	catalytic residue [active]
357804010378	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
357804010379	putative Ile/Val binding site [chemical binding]; other site
357804010380	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
357804010381	putative Ile/Val binding site [chemical binding]; other site
357804010382	Ion channel; Region: Ion_trans_2; pfam07885
357804010383	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
357804010384	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
357804010385	N-terminal plug; other site
357804010386	ligand-binding site [chemical binding]; other site
357804010387	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
357804010388	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
357804010389	intersubunit interface [polypeptide binding]; other site
357804010390	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
357804010391	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
357804010392	ABC-ATPase subunit  interface; other site
357804010393	dimer interface [polypeptide binding]; other site
357804010394	putative PBP binding regions; other site
357804010395	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
357804010396	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
357804010397	Walker A/P-loop; other site
357804010398	ATP binding site [chemical binding]; other site
357804010399	Q-loop/lid; other site
357804010400	ABC transporter signature motif; other site
357804010401	Walker B; other site
357804010402	D-loop; other site
357804010403	H-loop/switch region; other site
357804010404	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
357804010405	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
357804010406	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
357804010407	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
357804010408	SapC; Region: SapC; pfam07277
357804010409	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
357804010410	Prostaglandin dehydrogenases; Region: PGDH; cd05288
357804010411	NAD(P) binding site [chemical binding]; other site
357804010412	substrate binding site [chemical binding]; other site
357804010413	dimer interface [polypeptide binding]; other site
357804010414	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
357804010415	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
357804010416	dimer interface [polypeptide binding]; other site
357804010417	active site
357804010418	metal binding site [ion binding]; metal-binding site
357804010419	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
357804010420	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
357804010421	potential catalytic triad [active]
357804010422	conserved cys residue [active]
357804010423	transcriptional regulator; Provisional; Region: PRK10632
357804010424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804010425	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
357804010426	putative effector binding pocket; other site
357804010427	dimerization interface [polypeptide binding]; other site
357804010428	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
357804010429	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
357804010430	putative DNA binding site [nucleotide binding]; other site
357804010431	putative Zn2+ binding site [ion binding]; other site
357804010432	AsnC family; Region: AsnC_trans_reg; pfam01037
357804010433	2-isopropylmalate synthase; Validated; Region: PRK03739
357804010434	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
357804010435	active site
357804010436	catalytic residues [active]
357804010437	metal binding site [ion binding]; metal-binding site
357804010438	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
357804010439	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
357804010440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804010441	ATP binding site [chemical binding]; other site
357804010442	Mg2+ binding site [ion binding]; other site
357804010443	G-X-G motif; other site
357804010444	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
357804010445	anchoring element; other site
357804010446	dimer interface [polypeptide binding]; other site
357804010447	ATP binding site [chemical binding]; other site
357804010448	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
357804010449	active site
357804010450	metal binding site [ion binding]; metal-binding site
357804010451	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
357804010452	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
357804010453	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
357804010454	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
357804010455	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
357804010456	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
357804010457	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
357804010458	active site
357804010459	metal binding site [ion binding]; metal-binding site
357804010460	hexamer interface [polypeptide binding]; other site
357804010461	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
357804010462	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
357804010463	dimer interface [polypeptide binding]; other site
357804010464	ADP-ribose binding site [chemical binding]; other site
357804010465	active site
357804010466	nudix motif; other site
357804010467	metal binding site [ion binding]; metal-binding site
357804010468	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
357804010469	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
357804010470	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
357804010471	putative ribose interaction site [chemical binding]; other site
357804010472	putative ADP binding site [chemical binding]; other site
357804010473	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
357804010474	active site
357804010475	nucleotide binding site [chemical binding]; other site
357804010476	HIGH motif; other site
357804010477	KMSKS motif; other site
357804010478	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
357804010479	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
357804010480	ligand binding site [chemical binding]; other site
357804010481	flexible hinge region; other site
357804010482	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
357804010483	dimer interface [polypeptide binding]; other site
357804010484	phosphorylation site [posttranslational modification]
357804010485	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
357804010486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804010487	ATP binding site [chemical binding]; other site
357804010488	Mg2+ binding site [ion binding]; other site
357804010489	G-X-G motif; other site
357804010490	Protein of unknown function (DUF454); Region: DUF454; cl01063
357804010491	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
357804010492	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
357804010493	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
357804010494	RimM N-terminal domain; Region: RimM; pfam01782
357804010495	PRC-barrel domain; Region: PRC; pfam05239
357804010496	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
357804010497	signal recognition particle protein; Provisional; Region: PRK10867
357804010498	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
357804010499	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
357804010500	P loop; other site
357804010501	GTP binding site [chemical binding]; other site
357804010502	Signal peptide binding domain; Region: SRP_SPB; pfam02978
357804010503	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
357804010504	hypothetical protein; Provisional; Region: PRK11573
357804010505	Domain of unknown function DUF21; Region: DUF21; pfam01595
357804010506	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
357804010507	Transporter associated domain; Region: CorC_HlyC; smart01091
357804010508	S-ribosylhomocysteinase; Provisional; Region: PRK02260
357804010509	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
357804010510	N-acetyl-D-glucosamine binding site [chemical binding]; other site
357804010511	catalytic residue [active]
357804010512	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
357804010513	Predicted membrane protein [Function unknown]; Region: COG1238
357804010514	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
357804010515	oxaloacetate decarboxylase; Provisional; Region: PRK14040
357804010516	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
357804010517	active site
357804010518	catalytic residues [active]
357804010519	metal binding site [ion binding]; metal-binding site
357804010520	homodimer binding site [polypeptide binding]; other site
357804010521	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
357804010522	carboxyltransferase (CT) interaction site; other site
357804010523	biotinylation site [posttranslational modification]; other site
357804010524	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK03814
357804010525	carbon storage regulator; Provisional; Region: PRK01712
357804010526	aspartate kinase; Reviewed; Region: PRK06635
357804010527	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
357804010528	putative nucleotide binding site [chemical binding]; other site
357804010529	putative catalytic residues [active]
357804010530	putative Mg ion binding site [ion binding]; other site
357804010531	putative aspartate binding site [chemical binding]; other site
357804010532	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
357804010533	putative allosteric regulatory site; other site
357804010534	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
357804010535	putative allosteric regulatory residue; other site
357804010536	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
357804010537	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
357804010538	motif 1; other site
357804010539	active site
357804010540	motif 2; other site
357804010541	motif 3; other site
357804010542	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
357804010543	DHHA1 domain; Region: DHHA1; pfam02272
357804010544	recombinase A; Provisional; Region: recA; PRK09354
357804010545	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
357804010546	hexamer interface [polypeptide binding]; other site
357804010547	Walker A motif; other site
357804010548	ATP binding site [chemical binding]; other site
357804010549	Walker B motif; other site
357804010550	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
357804010551	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
357804010552	MutS domain I; Region: MutS_I; pfam01624
357804010553	MutS domain II; Region: MutS_II; pfam05188
357804010554	MutS domain III; Region: MutS_III; pfam05192
357804010555	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
357804010556	Walker A/P-loop; other site
357804010557	ATP binding site [chemical binding]; other site
357804010558	Q-loop/lid; other site
357804010559	ABC transporter signature motif; other site
357804010560	Walker B; other site
357804010561	D-loop; other site
357804010562	H-loop/switch region; other site
357804010563	EF-hand domain pair; Region: EF_hand_5; pfam13499
357804010564	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
357804010565	Ca2+ binding site [ion binding]; other site
357804010566	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804010567	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804010568	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
357804010569	dimerization interface [polypeptide binding]; other site
357804010570	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
357804010571	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
357804010572	THF binding site; other site
357804010573	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
357804010574	substrate binding site [chemical binding]; other site
357804010575	THF binding site; other site
357804010576	zinc-binding site [ion binding]; other site
357804010577	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
357804010578	metal binding site [ion binding]; metal-binding site
357804010579	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
357804010580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804010581	Major Facilitator Superfamily; Region: MFS_1; pfam07690
357804010582	putative substrate translocation pore; other site
357804010583	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
357804010584	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
357804010585	dimer interface [polypeptide binding]; other site
357804010586	ssDNA binding site [nucleotide binding]; other site
357804010587	tetramer (dimer of dimers) interface [polypeptide binding]; other site
357804010588	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
357804010589	PAS domain S-box; Region: sensory_box; TIGR00229
357804010590	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804010591	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804010592	metal binding site [ion binding]; metal-binding site
357804010593	active site
357804010594	I-site; other site
357804010595	HD domain; Region: HD_5; pfam13487
357804010596	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
357804010597	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
357804010598	Zn2+ binding site [ion binding]; other site
357804010599	Mg2+ binding site [ion binding]; other site
357804010600	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
357804010601	active site
357804010602	homodimer interface [polypeptide binding]; other site
357804010603	Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053
357804010604	diiron binding motif [ion binding]; other site
357804010605	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
357804010606	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804010607	ATP binding site [chemical binding]; other site
357804010608	putative Mg++ binding site [ion binding]; other site
357804010609	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804010610	nucleotide binding region [chemical binding]; other site
357804010611	ATP-binding site [chemical binding]; other site
357804010612	Uncharacterized conserved protein [Function unknown]; Region: COG3148
357804010613	putative hydrolase; Provisional; Region: PRK10976
357804010614	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804010615	active site
357804010616	motif I; other site
357804010617	motif II; other site
357804010618	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
357804010619	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
357804010620	Walker A motif; other site
357804010621	LysE type translocator; Region: LysE; cl00565
357804010622	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
357804010623	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
357804010624	active site
357804010625	catalytic tetrad [active]
357804010626	Protein of unknown function (DUF3996); Region: DUF3996; pfam13161
357804010627	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
357804010628	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
357804010629	active site residue [active]
357804010630	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
357804010631	dimer interface [polypeptide binding]; other site
357804010632	Alkaline phosphatase homologues; Region: alkPPc; smart00098
357804010633	active site
357804010634	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
357804010635	dimer interface [polypeptide binding]; other site
357804010636	Alkaline phosphatase homologues; Region: alkPPc; smart00098
357804010637	active site
357804010638	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
357804010639	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
357804010640	ligand binding site [chemical binding]; other site
357804010641	exoribonuclease R; Provisional; Region: PRK11642
357804010642	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
357804010643	RNB domain; Region: RNB; pfam00773
357804010644	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
357804010645	RNA binding site [nucleotide binding]; other site
357804010646	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
357804010647	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
357804010648	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
357804010649	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
357804010650	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
357804010651	dimer interface [polypeptide binding]; other site
357804010652	ssDNA binding site [nucleotide binding]; other site
357804010653	tetramer (dimer of dimers) interface [polypeptide binding]; other site
357804010654	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
357804010655	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
357804010656	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
357804010657	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
357804010658	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
357804010659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804010660	dimer interface [polypeptide binding]; other site
357804010661	conserved gate region; other site
357804010662	putative PBP binding loops; other site
357804010663	ABC-ATPase subunit interface; other site
357804010664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804010665	dimer interface [polypeptide binding]; other site
357804010666	conserved gate region; other site
357804010667	putative PBP binding loops; other site
357804010668	ABC-ATPase subunit interface; other site
357804010669	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
357804010670	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
357804010671	Walker A/P-loop; other site
357804010672	ATP binding site [chemical binding]; other site
357804010673	Q-loop/lid; other site
357804010674	ABC transporter signature motif; other site
357804010675	Walker B; other site
357804010676	D-loop; other site
357804010677	H-loop/switch region; other site
357804010678	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
357804010679	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
357804010680	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
357804010681	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
357804010682	dimer interface [polypeptide binding]; other site
357804010683	putative anticodon binding site; other site
357804010684	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
357804010685	motif 1; other site
357804010686	active site
357804010687	motif 2; other site
357804010688	motif 3; other site
357804010689	peptide chain release factor 2; Provisional; Region: PRK08787
357804010690	This domain is found in peptide chain release factors; Region: PCRF; smart00937
357804010691	RF-1 domain; Region: RF-1; pfam00472
357804010692	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
357804010693	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
357804010694	PYR/PP interface [polypeptide binding]; other site
357804010695	dimer interface [polypeptide binding]; other site
357804010696	TPP binding site [chemical binding]; other site
357804010697	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
357804010698	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
357804010699	TPP-binding site [chemical binding]; other site
357804010700	dimer interface [polypeptide binding]; other site
357804010701	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
357804010702	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
357804010703	putative valine binding site [chemical binding]; other site
357804010704	dimer interface [polypeptide binding]; other site
357804010705	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
357804010706	Protein of unknown function (DUF461); Region: DUF461; pfam04314
357804010707	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
357804010708	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
357804010709	Flavodoxin; Region: Flavodoxin_1; pfam00258
357804010710	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
357804010711	FAD binding pocket [chemical binding]; other site
357804010712	FAD binding motif [chemical binding]; other site
357804010713	catalytic residues [active]
357804010714	NAD binding pocket [chemical binding]; other site
357804010715	phosphate binding motif [ion binding]; other site
357804010716	beta-alpha-beta structure motif; other site
357804010717	sulfite reductase subunit beta; Provisional; Region: PRK13504
357804010718	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
357804010719	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
357804010720	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
357804010721	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
357804010722	Active Sites [active]
357804010723	elongation factor Tu; Reviewed; Region: PRK00049
357804010724	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
357804010725	G1 box; other site
357804010726	GEF interaction site [polypeptide binding]; other site
357804010727	GTP/Mg2+ binding site [chemical binding]; other site
357804010728	Switch I region; other site
357804010729	G2 box; other site
357804010730	G3 box; other site
357804010731	Switch II region; other site
357804010732	G4 box; other site
357804010733	G5 box; other site
357804010734	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
357804010735	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
357804010736	Antibiotic Binding Site [chemical binding]; other site
357804010737	elongation factor G; Reviewed; Region: PRK00007
357804010738	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
357804010739	G1 box; other site
357804010740	putative GEF interaction site [polypeptide binding]; other site
357804010741	GTP/Mg2+ binding site [chemical binding]; other site
357804010742	Switch I region; other site
357804010743	G2 box; other site
357804010744	G3 box; other site
357804010745	Switch II region; other site
357804010746	G4 box; other site
357804010747	G5 box; other site
357804010748	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
357804010749	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
357804010750	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
357804010751	30S ribosomal protein S7; Validated; Region: PRK05302
357804010752	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
357804010753	S17 interaction site [polypeptide binding]; other site
357804010754	S8 interaction site; other site
357804010755	16S rRNA interaction site [nucleotide binding]; other site
357804010756	streptomycin interaction site [chemical binding]; other site
357804010757	23S rRNA interaction site [nucleotide binding]; other site
357804010758	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
357804010759	DsrH like protein; Region: DsrH; pfam04077
357804010760	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
357804010761	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
357804010762	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
357804010763	homotrimer interaction site [polypeptide binding]; other site
357804010764	putative active site [active]
357804010765	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
357804010766	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
357804010767	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
357804010768	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
357804010769	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
357804010770	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
357804010771	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
357804010772	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
357804010773	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
357804010774	DNA binding site [nucleotide binding]
357804010775	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
357804010776	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
357804010777	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
357804010778	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
357804010779	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
357804010780	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
357804010781	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
357804010782	RPB3 interaction site [polypeptide binding]; other site
357804010783	RPB1 interaction site [polypeptide binding]; other site
357804010784	RPB11 interaction site [polypeptide binding]; other site
357804010785	RPB10 interaction site [polypeptide binding]; other site
357804010786	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
357804010787	core dimer interface [polypeptide binding]; other site
357804010788	peripheral dimer interface [polypeptide binding]; other site
357804010789	L10 interface [polypeptide binding]; other site
357804010790	L11 interface [polypeptide binding]; other site
357804010791	putative EF-Tu interaction site [polypeptide binding]; other site
357804010792	putative EF-G interaction site [polypeptide binding]; other site
357804010793	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
357804010794	23S rRNA interface [nucleotide binding]; other site
357804010795	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
357804010796	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
357804010797	mRNA/rRNA interface [nucleotide binding]; other site
357804010798	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
357804010799	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
357804010800	23S rRNA interface [nucleotide binding]; other site
357804010801	L7/L12 interface [polypeptide binding]; other site
357804010802	putative thiostrepton binding site; other site
357804010803	L25 interface [polypeptide binding]; other site
357804010804	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
357804010805	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
357804010806	putative homodimer interface [polypeptide binding]; other site
357804010807	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
357804010808	heterodimer interface [polypeptide binding]; other site
357804010809	homodimer interface [polypeptide binding]; other site
357804010810	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
357804010811	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
357804010812	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804010813	Walker A/P-loop; other site
357804010814	ATP binding site [chemical binding]; other site
357804010815	Q-loop/lid; other site
357804010816	ABC transporter signature motif; other site
357804010817	Walker B; other site
357804010818	D-loop; other site
357804010819	H-loop/switch region; other site
357804010820	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
357804010821	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
357804010822	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
357804010823	Walker A/P-loop; other site
357804010824	ATP binding site [chemical binding]; other site
357804010825	Q-loop/lid; other site
357804010826	ABC transporter signature motif; other site
357804010827	Walker B; other site
357804010828	D-loop; other site
357804010829	H-loop/switch region; other site
357804010830	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
357804010831	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
357804010832	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
357804010833	NAD(P) binding site [chemical binding]; other site
357804010834	homodimer interface [polypeptide binding]; other site
357804010835	substrate binding site [chemical binding]; other site
357804010836	active site
357804010837	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
357804010838	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
357804010839	putative NAD(P) binding site [chemical binding]; other site
357804010840	active site
357804010841	putative substrate binding site [chemical binding]; other site
357804010842	Bacterial sugar transferase; Region: Bac_transf; pfam02397
357804010843	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
357804010844	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
357804010845	active site
357804010846	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
357804010847	Methyltransferase domain; Region: Methyltransf_23; pfam13489
357804010848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
357804010849	S-adenosylmethionine binding site [chemical binding]; other site
357804010850	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
357804010851	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
357804010852	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
357804010853	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
357804010854	Walker A/P-loop; other site
357804010855	ATP binding site [chemical binding]; other site
357804010856	Q-loop/lid; other site
357804010857	ABC transporter signature motif; other site
357804010858	Walker B; other site
357804010859	D-loop; other site
357804010860	H-loop/switch region; other site
357804010861	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
357804010862	putative carbohydrate binding site [chemical binding]; other site
357804010863	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
357804010864	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
357804010865	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
357804010866	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
357804010867	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
357804010868	NADP binding site [chemical binding]; other site
357804010869	active site
357804010870	putative substrate binding site [chemical binding]; other site
357804010871	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
357804010872	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
357804010873	substrate binding site; other site
357804010874	tetramer interface; other site
357804010875	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
357804010876	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
357804010877	NAD binding site [chemical binding]; other site
357804010878	substrate binding site [chemical binding]; other site
357804010879	homodimer interface [polypeptide binding]; other site
357804010880	active site
357804010881	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
357804010882	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
357804010883	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
357804010884	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
357804010885	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
357804010886	Chorismate lyase; Region: Chor_lyase; cl01230
357804010887	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
357804010888	UbiA prenyltransferase family; Region: UbiA; pfam01040
357804010889	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
357804010890	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
357804010891	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
357804010892	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
357804010893	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
357804010894	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
357804010895	catalytic triad [active]
357804010896	dimer interface [polypeptide binding]; other site
357804010897	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
357804010898	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
357804010899	Part of AAA domain; Region: AAA_19; pfam13245
357804010900	Family description; Region: UvrD_C_2; pfam13538
357804010901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
357804010902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
357804010903	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
357804010904	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
357804010905	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804010906	multidrug efflux protein; Reviewed; Region: PRK09579
357804010907	Protein export membrane protein; Region: SecD_SecF; cl14618
357804010908	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
357804010909	UDP-glucose 4-epimerase; Region: PLN02240
357804010910	NAD binding site [chemical binding]; other site
357804010911	homodimer interface [polypeptide binding]; other site
357804010912	active site
357804010913	substrate binding site [chemical binding]; other site
357804010914	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
357804010915	active site
357804010916	ribonuclease PH; Reviewed; Region: rph; PRK00173
357804010917	Ribonuclease PH; Region: RNase_PH_bact; cd11362
357804010918	hexamer interface [polypeptide binding]; other site
357804010919	active site
357804010920	protease3; Provisional; Region: PRK15101
357804010921	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
357804010922	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
357804010923	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
357804010924	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
357804010925	putative active site [active]
357804010926	dimerization interface [polypeptide binding]; other site
357804010927	putative tRNAtyr binding site [nucleotide binding]; other site
357804010928	hypothetical protein; Reviewed; Region: PRK01637
357804010929	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
357804010930	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
357804010931	G1 box; other site
357804010932	putative GEF interaction site [polypeptide binding]; other site
357804010933	GTP/Mg2+ binding site [chemical binding]; other site
357804010934	Switch I region; other site
357804010935	G2 box; other site
357804010936	G3 box; other site
357804010937	Switch II region; other site
357804010938	G4 box; other site
357804010939	G5 box; other site
357804010940	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
357804010941	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
357804010942	glutamine synthetase; Provisional; Region: glnA; PRK09469
357804010943	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
357804010944	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
357804010945	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
357804010946	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
357804010947	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
357804010948	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
357804010949	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
357804010950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
357804010951	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804010952	dimer interface [polypeptide binding]; other site
357804010953	phosphorylation site [posttranslational modification]
357804010954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804010955	ATP binding site [chemical binding]; other site
357804010956	Mg2+ binding site [ion binding]; other site
357804010957	G-X-G motif; other site
357804010958	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
357804010959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804010960	active site
357804010961	phosphorylation site [posttranslational modification]
357804010962	intermolecular recognition site; other site
357804010963	dimerization interface [polypeptide binding]; other site
357804010964	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804010965	Walker A motif; other site
357804010966	ATP binding site [chemical binding]; other site
357804010967	Walker B motif; other site
357804010968	arginine finger; other site
357804010969	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
357804010970	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
357804010971	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
357804010972	Na binding site [ion binding]; other site
357804010973	AsmA family; Region: AsmA; pfam05170
357804010974	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
357804010975	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
357804010976	ssDNA binding site; other site
357804010977	generic binding surface II; other site
357804010978	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
357804010979	ATP binding site [chemical binding]; other site
357804010980	putative Mg++ binding site [ion binding]; other site
357804010981	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
357804010982	nucleotide binding region [chemical binding]; other site
357804010983	ATP-binding site [chemical binding]; other site
357804010984	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
357804010985	dimerization interface [polypeptide binding]; other site
357804010986	substrate binding site [chemical binding]; other site
357804010987	active site
357804010988	calcium binding site [ion binding]; other site
357804010989	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
357804010990	G1 box; other site
357804010991	GTP/Mg2+ binding site [chemical binding]; other site
357804010992	G2 box; other site
357804010993	Switch I region; other site
357804010994	G3 box; other site
357804010995	Switch II region; other site
357804010996	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
357804010997	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
357804010998	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
357804010999	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
357804011000	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
357804011001	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
357804011002	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804011003	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
357804011004	dimerization interface [polypeptide binding]; other site
357804011005	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
357804011006	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
357804011007	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
357804011008	alphaNTD homodimer interface [polypeptide binding]; other site
357804011009	alphaNTD - beta interaction site [polypeptide binding]; other site
357804011010	alphaNTD - beta' interaction site [polypeptide binding]; other site
357804011011	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
357804011012	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
357804011013	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
357804011014	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
357804011015	RNA binding surface [nucleotide binding]; other site
357804011016	30S ribosomal protein S11; Validated; Region: PRK05309
357804011017	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
357804011018	30S ribosomal protein S13; Region: bact_S13; TIGR03631
357804011019	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
357804011020	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
357804011021	SecY translocase; Region: SecY; pfam00344
357804011022	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
357804011023	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
357804011024	23S rRNA binding site [nucleotide binding]; other site
357804011025	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
357804011026	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
357804011027	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
357804011028	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
357804011029	5S rRNA interface [nucleotide binding]; other site
357804011030	L5 interface [polypeptide binding]; other site
357804011031	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
357804011032	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
357804011033	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
357804011034	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
357804011035	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
357804011036	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
357804011037	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
357804011038	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
357804011039	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
357804011040	RNA binding site [nucleotide binding]; other site
357804011041	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
357804011042	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
357804011043	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
357804011044	23S rRNA interface [nucleotide binding]; other site
357804011045	putative translocon interaction site; other site
357804011046	signal recognition particle (SRP54) interaction site; other site
357804011047	L23 interface [polypeptide binding]; other site
357804011048	trigger factor interaction site; other site
357804011049	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
357804011050	23S rRNA interface [nucleotide binding]; other site
357804011051	5S rRNA interface [nucleotide binding]; other site
357804011052	putative antibiotic binding site [chemical binding]; other site
357804011053	L25 interface [polypeptide binding]; other site
357804011054	L27 interface [polypeptide binding]; other site
357804011055	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
357804011056	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
357804011057	G-X-X-G motif; other site
357804011058	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
357804011059	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
357804011060	putative translocon binding site; other site
357804011061	protein-rRNA interface [nucleotide binding]; other site
357804011062	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
357804011063	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
357804011064	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
357804011065	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
357804011066	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
357804011067	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
357804011068	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
357804011069	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
357804011070	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
357804011071	Helicase; Region: Helicase_RecD; pfam05127
357804011072	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804011073	Coenzyme A binding pocket [chemical binding]; other site
357804011074	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
357804011075	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
357804011076	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
357804011077	RNA binding surface [nucleotide binding]; other site
357804011078	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
357804011079	active site
357804011080	uracil binding [chemical binding]; other site
357804011081	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
357804011082	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
357804011083	motif II; other site
357804011084	LysR family transcriptional regulator; Provisional; Region: PRK14997
357804011085	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804011086	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
357804011087	dimerization interface [polypeptide binding]; other site
357804011088	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
357804011089	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
357804011090	substrate binding site [chemical binding]; other site
357804011091	catalytic Zn binding site [ion binding]; other site
357804011092	NAD binding site [chemical binding]; other site
357804011093	structural Zn binding site [ion binding]; other site
357804011094	dimer interface [polypeptide binding]; other site
357804011095	S-formylglutathione hydrolase; Region: PLN02442
357804011096	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
357804011097	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
357804011098	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
357804011099	putative metal binding site [ion binding]; other site
357804011100	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
357804011101	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804011102	Coenzyme A binding pocket [chemical binding]; other site
357804011103	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
357804011104	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
357804011105	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
357804011106	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
357804011107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804011108	dimer interface [polypeptide binding]; other site
357804011109	conserved gate region; other site
357804011110	ABC-ATPase subunit interface; other site
357804011111	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
357804011112	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
357804011113	Walker A/P-loop; other site
357804011114	ATP binding site [chemical binding]; other site
357804011115	Q-loop/lid; other site
357804011116	ABC transporter signature motif; other site
357804011117	Walker B; other site
357804011118	D-loop; other site
357804011119	H-loop/switch region; other site
357804011120	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
357804011121	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
357804011122	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
357804011123	active site
357804011124	Protein of unknown function, DUF479; Region: DUF479; cl01203
357804011125	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
357804011126	putative amphipathic alpha helix; other site
357804011127	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
357804011128	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
357804011129	putative NAD(P) binding site [chemical binding]; other site
357804011130	dimer interface [polypeptide binding]; other site
357804011131	MarR family; Region: MarR_2; cl17246
357804011132	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
357804011133	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
357804011134	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
357804011135	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
357804011136	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
357804011137	putative active site [active]
357804011138	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
357804011139	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
357804011140	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
357804011141	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
357804011142	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
357804011143	DNA binding site [nucleotide binding]
357804011144	domain linker motif; other site
357804011145	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
357804011146	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
357804011147	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
357804011148	active site
357804011149	phosphorylation site [posttranslational modification]
357804011150	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
357804011151	active site
357804011152	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
357804011153	dimerization domain swap beta strand [polypeptide binding]; other site
357804011154	regulatory protein interface [polypeptide binding]; other site
357804011155	active site
357804011156	regulatory phosphorylation site [posttranslational modification]; other site
357804011157	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
357804011158	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
357804011159	putative substrate binding site [chemical binding]; other site
357804011160	putative ATP binding site [chemical binding]; other site
357804011161	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
357804011162	active site
357804011163	P-loop; other site
357804011164	phosphorylation site [posttranslational modification]
357804011165	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
357804011166	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
357804011167	active site
357804011168	P-loop; other site
357804011169	phosphorylation site [posttranslational modification]
357804011170	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
357804011171	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
357804011172	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
357804011173	AMP binding site [chemical binding]; other site
357804011174	metal binding site [ion binding]; metal-binding site
357804011175	active site
357804011176	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
357804011177	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
357804011178	Protein of unknown function (DUF2860); Region: DUF2860; pfam11059
357804011179	SAF-like; Region: SAF_2; pfam13144
357804011180	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
357804011181	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
357804011182	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
357804011183	Mg binding site [ion binding]; other site
357804011184	nucleotide binding site [chemical binding]; other site
357804011185	putative protofilament interface [polypeptide binding]; other site
357804011186	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
357804011187	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
357804011188	Walker A motif; other site
357804011189	ATP binding site [chemical binding]; other site
357804011190	Walker B motif; other site
357804011191	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
357804011192	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
357804011193	Flagellar assembly protein FliH; Region: FliH; pfam02108
357804011194	flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194
357804011195	FliG C-terminal domain; Region: FliG_C; pfam01706
357804011196	flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193
357804011197	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
357804011198	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
357804011199	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
357804011200	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
357804011201	ligand binding site [chemical binding]; other site
357804011202	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
357804011203	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
357804011204	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
357804011205	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
357804011206	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
357804011207	Rod binding protein; Region: Rod-binding; cl01626
357804011208	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
357804011209	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
357804011210	Flagellar L-ring protein; Region: FlgH; pfam02107
357804011211	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
357804011212	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
357804011213	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
357804011214	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
357804011215	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
357804011216	flagellar hook protein FlgE; Validated; Region: flgE; PRK06803
357804011217	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
357804011218	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
357804011219	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
357804011220	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619
357804011221	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
357804011222	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
357804011223	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802
357804011224	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
357804011225	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
357804011226	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
357804011227	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685
357804011228	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
357804011229	hypothetical protein; Validated; Region: PRK06778
357804011230	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
357804011231	ligand binding site [chemical binding]; other site
357804011232	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
357804011233	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
357804011234	flagellar biosynthesis sigma factor; Provisional; Region: PRK12427
357804011235	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
357804011236	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
357804011237	DNA binding residues [nucleotide binding]
357804011238	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
357804011239	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
357804011240	Flagellar protein FliS; Region: FliS; cl00654
357804011241	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
357804011242	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
357804011243	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
357804011244	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
357804011245	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
357804011246	flagellin; Reviewed; Region: PRK08869
357804011247	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
357804011248	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
357804011249	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
357804011250	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
357804011251	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
357804011252	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
357804011253	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
357804011254	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
357804011255	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
357804011256	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
357804011257	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
357804011258	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
357804011259	FHIPEP family; Region: FHIPEP; pfam00771
357804011260	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
357804011261	FlgN protein; Region: FlgN; pfam05130
357804011262	acetyl-CoA synthetase; Provisional; Region: PRK04319
357804011263	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
357804011264	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
357804011265	active site
357804011266	acyl-activating enzyme (AAE) consensus motif; other site
357804011267	putative CoA binding site [chemical binding]; other site
357804011268	AMP binding site [chemical binding]; other site
357804011269	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
357804011270	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
357804011271	tetramer interface [polypeptide binding]; other site
357804011272	TPP-binding site [chemical binding]; other site
357804011273	heterodimer interface [polypeptide binding]; other site
357804011274	phosphorylation loop region [posttranslational modification]
357804011275	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
357804011276	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
357804011277	alpha subunit interface [polypeptide binding]; other site
357804011278	TPP binding site [chemical binding]; other site
357804011279	heterodimer interface [polypeptide binding]; other site
357804011280	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
357804011281	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
357804011282	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
357804011283	E3 interaction surface; other site
357804011284	lipoyl attachment site [posttranslational modification]; other site
357804011285	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
357804011286	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
357804011287	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
357804011288	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
357804011289	hexamer interface [polypeptide binding]; other site
357804011290	ligand binding site [chemical binding]; other site
357804011291	putative active site [active]
357804011292	NAD(P) binding site [chemical binding]; other site
357804011293	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
357804011294	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
357804011295	putative DNA binding site [nucleotide binding]; other site
357804011296	putative Zn2+ binding site [ion binding]; other site
357804011297	AsnC family; Region: AsnC_trans_reg; pfam01037
357804011298	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
357804011299	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
357804011300	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
357804011301	DsbD alpha interface [polypeptide binding]; other site
357804011302	catalytic residues [active]
357804011303	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
357804011304	ribonuclease P; Reviewed; Region: rnpA; PRK01732
357804011305	Haemolytic domain; Region: Haemolytic; pfam01809
357804011306	membrane protein insertase; Provisional; Region: PRK01318
357804011307	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
357804011308	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
357804011309	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
357804011310	trmE is a tRNA modification GTPase; Region: trmE; cd04164
357804011311	G1 box; other site
357804011312	GTP/Mg2+ binding site [chemical binding]; other site
357804011313	Switch I region; other site
357804011314	G2 box; other site
357804011315	Switch II region; other site
357804011316	G3 box; other site
357804011317	G4 box; other site
357804011318	G5 box; other site
357804011319	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
357804011320	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
357804011321	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
357804011322	trimer interface [polypeptide binding]; other site
357804011323	eyelet of channel; other site
357804011324	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
357804011325	TIGR01777 family protein; Region: yfcH
357804011326	putative NAD(P) binding site [chemical binding]; other site
357804011327	putative active site [active]
357804011328	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
357804011329	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
357804011330	glutamine binding [chemical binding]; other site
357804011331	catalytic triad [active]
357804011332	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
357804011333	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
357804011334	inhibitor-cofactor binding pocket; inhibition site
357804011335	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804011336	catalytic residue [active]
357804011337	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
357804011338	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
357804011339	putative active site [active]
357804011340	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
357804011341	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
357804011342	serine/threonine protein kinase; Provisional; Region: PRK11768
357804011343	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
357804011344	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
357804011345	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
357804011346	catalytic residues [active]
357804011347	hinge region; other site
357804011348	alpha helical domain; other site
357804011349	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
357804011350	active site
357804011351	pantothenate kinase; Provisional; Region: PRK05439
357804011352	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
357804011353	ATP-binding site [chemical binding]; other site
357804011354	CoA-binding site [chemical binding]; other site
357804011355	Mg2+-binding site [ion binding]; other site
357804011356	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
357804011357	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
357804011358	catalytic site [active]
357804011359	G-X2-G-X-G-K; other site
357804011360	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
357804011361	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
357804011362	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
357804011363	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
357804011364	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
357804011365	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
357804011366	NAD(P) binding site [chemical binding]; other site
357804011367	active site
357804011368	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
357804011369	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
357804011370	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
357804011371	C-terminal domain interface [polypeptide binding]; other site
357804011372	GSH binding site (G-site) [chemical binding]; other site
357804011373	dimer interface [polypeptide binding]; other site
357804011374	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
357804011375	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
357804011376	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
357804011377	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
357804011378	active site residue [active]
357804011379	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
357804011380	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
357804011381	dimerization interface [polypeptide binding]; other site
357804011382	putative DNA binding site [nucleotide binding]; other site
357804011383	putative Zn2+ binding site [ion binding]; other site
357804011384	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
357804011385	Predicted transporter component [General function prediction only]; Region: COG2391
357804011386	Predicted transporter component [General function prediction only]; Region: COG2391
357804011387	Sulphur transport; Region: Sulf_transp; pfam04143
357804011388	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
357804011389	Predicted permease; Region: DUF318; cl17795
357804011390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
357804011391	putative substrate translocation pore; other site
357804011392	Major Facilitator Superfamily; Region: MFS_1; pfam07690
357804011393	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
357804011394	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
357804011395	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
357804011396	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
357804011397	dimerization interface [polypeptide binding]; other site
357804011398	putative DNA binding site [nucleotide binding]; other site
357804011399	putative Zn2+ binding site [ion binding]; other site
357804011400	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
357804011401	active site
357804011402	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
357804011403	HemY protein N-terminus; Region: HemY_N; pfam07219
357804011404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
357804011405	binding surface
357804011406	TPR motif; other site
357804011407	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
357804011408	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
357804011409	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
357804011410	active site
357804011411	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
357804011412	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
357804011413	domain interfaces; other site
357804011414	active site
357804011415	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
357804011416	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
357804011417	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
357804011418	homodimer interface [polypeptide binding]; other site
357804011419	substrate-cofactor binding pocket; other site
357804011420	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804011421	catalytic residue [active]
357804011422	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
357804011423	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
357804011424	Coenzyme A binding pocket [chemical binding]; other site
357804011425	MAPEG family; Region: MAPEG; pfam01124
357804011426	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
357804011427	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
357804011428	dihydrodipicolinate reductase; Provisional; Region: PRK00048
357804011429	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
357804011430	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
357804011431	Protein of unknown function (DUF2956); Region: DUF2956; pfam11169
357804011432	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
357804011433	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
357804011434	hypothetical protein; Provisional; Region: PRK11820
357804011435	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
357804011436	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
357804011437	Protein with unknown function (DUF469); Region: DUF469; pfam04320
357804011438	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
357804011439	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
357804011440	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
357804011441	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
357804011442	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
357804011443	Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082
357804011444	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
357804011445	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
357804011446	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
357804011447	Coenzyme A transferase; Region: CoA_trans; cl17247
357804011448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
357804011449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
357804011450	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
357804011451	putative dimerization interface [polypeptide binding]; other site
357804011452	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
357804011453	dimer interface [polypeptide binding]; other site
357804011454	ADP-ribose binding site [chemical binding]; other site
357804011455	active site
357804011456	nudix motif; other site
357804011457	metal binding site [ion binding]; metal-binding site
357804011458	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
357804011459	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
357804011460	Transcriptional regulators [Transcription]; Region: GntR; COG1802
357804011461	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804011462	DNA-binding site [nucleotide binding]; DNA binding site
357804011463	FCD domain; Region: FCD; pfam07729
357804011464	putative transposase OrfB; Reviewed; Region: PHA02517
357804011465	HTH-like domain; Region: HTH_21; pfam13276
357804011466	Integrase core domain; Region: rve; pfam00665
357804011467	Integrase core domain; Region: rve_3; pfam13683
357804011468	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
357804011469	Transposase; Region: HTH_Tnp_1; pfam01527
357804011470	Transposase IS200 like; Region: Y1_Tnp; pfam01797
357804011471	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
357804011472	DctM-like transporters; Region: DctM; pfam06808
357804011473	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
357804011474	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
357804011475	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
357804011476	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
357804011477	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
357804011478	DDE superfamily endonuclease; Region: DDE_3; pfam13358
357804011479	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
357804011480	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
357804011481	dimer interface [polypeptide binding]; other site
357804011482	ADP-ribose binding site [chemical binding]; other site
357804011483	active site
357804011484	nudix motif; other site
357804011485	metal binding site [ion binding]; metal-binding site
357804011486	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
357804011487	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
357804011488	putative hydrolase; Provisional; Region: PRK02113
357804011489	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
357804011490	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
357804011491	active site
357804011492	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
357804011493	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
357804011494	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
357804011495	active site
357804011496	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
357804011497	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804011498	Walker A/P-loop; other site
357804011499	ATP binding site [chemical binding]; other site
357804011500	Q-loop/lid; other site
357804011501	ABC transporter signature motif; other site
357804011502	Walker B; other site
357804011503	D-loop; other site
357804011504	H-loop/switch region; other site
357804011505	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
357804011506	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
357804011507	Walker A/P-loop; other site
357804011508	ATP binding site [chemical binding]; other site
357804011509	Q-loop/lid; other site
357804011510	ABC transporter signature motif; other site
357804011511	Walker B; other site
357804011512	D-loop; other site
357804011513	H-loop/switch region; other site
357804011514	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
357804011515	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
357804011516	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
357804011517	phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293
357804011518	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
357804011519	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
357804011520	dimer interface [polypeptide binding]; other site
357804011521	conserved gate region; other site
357804011522	putative PBP binding loops; other site
357804011523	ABC-ATPase subunit interface; other site
357804011524	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
357804011525	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
357804011526	Walker A/P-loop; other site
357804011527	ATP binding site [chemical binding]; other site
357804011528	Q-loop/lid; other site
357804011529	ABC transporter signature motif; other site
357804011530	Walker B; other site
357804011531	D-loop; other site
357804011532	H-loop/switch region; other site
357804011533	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
357804011534	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
357804011535	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
357804011536	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
357804011537	DNA-binding site [nucleotide binding]; DNA binding site
357804011538	UTRA domain; Region: UTRA; pfam07702
357804011539	EamA-like transporter family; Region: EamA; cl17759
357804011540	Predicted permeases [General function prediction only]; Region: RarD; COG2962
357804011541	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
357804011542	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
357804011543	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
357804011544	dimer interface [polypeptide binding]; other site
357804011545	N-terminal domain interface [polypeptide binding]; other site
357804011546	substrate binding pocket (H-site) [chemical binding]; other site
357804011547	putative transcriptional regulator; Provisional; Region: PRK11640
357804011548	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
357804011549	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
357804011550	Sel1-like repeats; Region: SEL1; smart00671
357804011551	Sel1-like repeats; Region: SEL1; smart00671
357804011552	Sel1-like repeats; Region: SEL1; smart00671
357804011553	Sel1-like repeats; Region: SEL1; smart00671
357804011554	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
357804011555	Sel1-like repeats; Region: SEL1; smart00671
357804011556	Sel1-like repeats; Region: SEL1; smart00671
357804011557	Sel1-like repeats; Region: SEL1; smart00671
357804011558	Sel1-like repeats; Region: SEL1; smart00671
357804011559	Sel1-like repeats; Region: SEL1; smart00671
357804011560	Sel1-like repeats; Region: SEL1; smart00671
357804011561	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
357804011562	DNA-binding site [nucleotide binding]; DNA binding site
357804011563	RNA-binding motif; other site
357804011564	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
357804011565	catalytic residues [active]
357804011566	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
357804011567	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
357804011568	FtsX-like permease family; Region: FtsX; pfam02687
357804011569	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
357804011570	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
357804011571	FtsX-like permease family; Region: FtsX; pfam02687
357804011572	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
357804011573	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
357804011574	Walker A/P-loop; other site
357804011575	ATP binding site [chemical binding]; other site
357804011576	Q-loop/lid; other site
357804011577	ABC transporter signature motif; other site
357804011578	Walker B; other site
357804011579	D-loop; other site
357804011580	H-loop/switch region; other site
357804011581	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
357804011582	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
357804011583	HlyD family secretion protein; Region: HlyD_3; pfam13437
357804011584	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
357804011585	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
357804011586	Sulfate transporter family; Region: Sulfate_transp; pfam00916
357804011587	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
357804011588	DnaA N-terminal domain; Region: DnaA_N; pfam11638
357804011589	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
357804011590	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
357804011591	Walker A motif; other site
357804011592	ATP binding site [chemical binding]; other site
357804011593	Walker B motif; other site
357804011594	arginine finger; other site
357804011595	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
357804011596	DnaA box-binding interface [nucleotide binding]; other site
357804011597	DNA polymerase III subunit beta; Validated; Region: PRK05643
357804011598	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
357804011599	putative DNA binding surface [nucleotide binding]; other site
357804011600	dimer interface [polypeptide binding]; other site
357804011601	beta-clamp/clamp loader binding surface; other site
357804011602	beta-clamp/translesion DNA polymerase binding surface; other site
357804011603	recombination protein F; Reviewed; Region: recF; PRK00064
357804011604	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804011605	Walker A/P-loop; other site
357804011606	ATP binding site [chemical binding]; other site
357804011607	Q-loop/lid; other site
357804011608	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
357804011609	ABC transporter signature motif; other site
357804011610	Walker B; other site
357804011611	D-loop; other site
357804011612	H-loop/switch region; other site
357804011613	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
357804011614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804011615	ATP binding site [chemical binding]; other site
357804011616	Mg2+ binding site [ion binding]; other site
357804011617	G-X-G motif; other site
357804011618	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
357804011619	anchoring element; other site
357804011620	dimer interface [polypeptide binding]; other site
357804011621	ATP binding site [chemical binding]; other site
357804011622	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
357804011623	active site
357804011624	putative metal-binding site [ion binding]; other site
357804011625	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
357804011626	CHASE3 domain; Region: CHASE3; cl05000
357804011627	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
357804011628	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
357804011629	dimerization interface [polypeptide binding]; other site
357804011630	GAF domain; Region: GAF_2; pfam13185
357804011631	GAF domain; Region: GAF_3; pfam13492
357804011632	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
357804011633	dimer interface [polypeptide binding]; other site
357804011634	phosphorylation site [posttranslational modification]
357804011635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
357804011636	ATP binding site [chemical binding]; other site
357804011637	Mg2+ binding site [ion binding]; other site
357804011638	G-X-G motif; other site
357804011639	Response regulator receiver domain; Region: Response_reg; pfam00072
357804011640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804011641	active site
357804011642	phosphorylation site [posttranslational modification]
357804011643	intermolecular recognition site; other site
357804011644	dimerization interface [polypeptide binding]; other site
357804011645	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
357804011646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804011647	active site
357804011648	phosphorylation site [posttranslational modification]
357804011649	intermolecular recognition site; other site
357804011650	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
357804011651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804011652	active site
357804011653	phosphorylation site [posttranslational modification]
357804011654	intermolecular recognition site; other site
357804011655	dimerization interface [polypeptide binding]; other site
357804011656	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
357804011657	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
357804011658	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
357804011659	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
357804011660	CheB methylesterase; Region: CheB_methylest; pfam01339
357804011661	Response regulator receiver domain; Region: Response_reg; pfam00072
357804011662	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
357804011663	active site
357804011664	phosphorylation site [posttranslational modification]
357804011665	intermolecular recognition site; other site
357804011666	dimerization interface [polypeptide binding]; other site
357804011667	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
357804011668	PAS domain; Region: PAS_9; pfam13426
357804011669	putative active site [active]
357804011670	heme pocket [chemical binding]; other site
357804011671	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
357804011672	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
357804011673	metal binding site [ion binding]; metal-binding site
357804011674	active site
357804011675	I-site; other site
357804011676	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
357804011677	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
357804011678	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
357804011679	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
357804011680	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
357804011681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
357804011682	homodimer interface [polypeptide binding]; other site
357804011683	catalytic residue [active]
357804011684	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
357804011685	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
357804011686	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
357804011687	dimer interface [polypeptide binding]; other site
357804011688	motif 1; other site
357804011689	active site
357804011690	motif 2; other site
357804011691	motif 3; other site
357804011692	Uncharacterized conserved protein (DUF2161); Region: DUF2161; pfam09929
357804011693	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
357804011694	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
357804011695	gamma subunit interface [polypeptide binding]; other site
357804011696	epsilon subunit interface [polypeptide binding]; other site
357804011697	LBP interface [polypeptide binding]; other site
357804011698	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
357804011699	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
357804011700	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
357804011701	alpha subunit interaction interface [polypeptide binding]; other site
357804011702	Walker A motif; other site
357804011703	ATP binding site [chemical binding]; other site
357804011704	Walker B motif; other site
357804011705	inhibitor binding site; inhibition site
357804011706	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
357804011707	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
357804011708	core domain interface [polypeptide binding]; other site
357804011709	delta subunit interface [polypeptide binding]; other site
357804011710	epsilon subunit interface [polypeptide binding]; other site
357804011711	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
357804011712	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
357804011713	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
357804011714	beta subunit interaction interface [polypeptide binding]; other site
357804011715	Walker A motif; other site
357804011716	ATP binding site [chemical binding]; other site
357804011717	Walker B motif; other site
357804011718	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
357804011719	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
357804011720	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
357804011721	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
357804011722	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
357804011723	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
357804011724	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
357804011725	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
357804011726	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
357804011727	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
357804011728	ParB-like nuclease domain; Region: ParBc; pfam02195
357804011729	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
357804011730	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
357804011731	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
357804011732	P-loop; other site
357804011733	Magnesium ion binding site [ion binding]; other site
357804011734	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
357804011735	Magnesium ion binding site [ion binding]; other site
357804011736	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
357804011737	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
357804011738	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
357804011739	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
357804011740	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
357804011741	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438